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Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice Metabolism (IF 9.8) Pub Date : 2024-03-11 Logan A. Pendergrast, Stephen P. Ashcroft, Amy M. Ehrlich, Jonas T. Treebak, Anna Krook, Lucile Dollet, Juleen R. Zierath
Circadian disruption is widespread and increases the risk of obesity. Timing of therapeutic interventions may promote coherent and efficient gating of metabolic processes and restore energy homeostasis. To characterize the diurnal postexercise metabolic state in mice and to identify the influence of diet-induced obesity on identified outcomes. C57BL6/NTac male mice (6wks of age) were fed a standard
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Non-coding RNAs in diabetic peripheral neuropathy: their role and mechanisms underlying their effects Metabolism (IF 9.8) Pub Date : 2024-03-08 Yiqian He, Ling Qu
Diabetic peripheral neuropathy (DPN) is a complication of diabetes with a high rate of disability. However, current clinical treatments for DPN are suboptimal. Non-coding RNAs (ncRNAs) are a type of RNAs that are not translated into proteins. NcRNAs perform functions that regulate epigenetic modifications, transcriptional or post-transcriptional regulators of proteins, and thus participate in the physiological
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Interleukin-6 classic and trans-signaling utilize glucose metabolism reprogramming to achieve anti- or pro-inflammatory effects Metabolism (IF 9.8) Pub Date : 2024-03-02 Shilei Xu, Ke-Qiong Deng, Chengbo Lu, Xin Fu, Qingmei Zhu, Shiqi Wan, Lin Zhang, Yu Huang, Longyu Nie, Huanhuan Cai, Qiming Wang, Hao Zeng, Yufeng Zhang, Fubing Wang, Hong Ren, Yu Chen, Huan Yan, Ke Xu, Li Zhou, Mengji Lu, Ying Zhu, Shi Liu, Zhibing Lu
Interleukin (IL)-6 has anti- and pro-inflammatory functions, controlled by IL-6 classic and trans-signaling, respectively. Differences in the downstream signaling mechanism between IL-6 classic and trans-signaling have not been identified. Here, we report that IL-6 activates glycolysis to regulate the inflammatory response. IL-6 regulates glucose metabolism by forming a complex containing signal-transducing
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Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening Metabolism (IF 9.8) Pub Date : 2024-02-29 Liping Zhang, Zhe Sun, Yan Yang, Austin Mack, Mackenna Rodgers, Annayya Aroor, Guanghong Jia, James R. Sowers, Michael A. Hill
Excessive dietary salt intake increases vascular stiffness in humans, especially in salt-sensitive populations. While we recently suggested that the endothelial sodium channel (EnNaC) contributes to salt-sensitivity related endothelial cell (EC) and arterial stiffening, mechanistic understanding remains incomplete. This study therefore aimed to explore the role of EC-serum and glucocorticoid regulated
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Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis Metabolism (IF 9.8) Pub Date : 2024-02-28 Ye Zhou, Yuanqi Zhao, Marisa Carbonaro, Helen Chen, Mary Germino, Christina Adler, Min Ni, Yuan O. Zhu, Sun Y. Kim, Judith Altarejos, Zhe Li, Michael E. Burczynski, David J. Glass, Mark W. Sleeman, Ann-Hwee Lee, Gabor Halasz, Xiping Cheng
Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal hepatic function. Wnt signaling is a master regulator of spatial liver zonation. A perivenous-periportal Wnt activity gradient orchestrates metabolic zonation by activating gene expression in perivenous hepatocytes, while suppressing gene expression in their periportal counterparts. However
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Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation Metabolism (IF 9.8) Pub Date : 2024-02-17 Simran Pherwani, David Connolly, Qiuyu Sun, Qutuba G. Karwi, Michael Carr, Kim L. Ho, Cory S. Wagg, Liyan Zhang, Jody Levasseur, Heidi Silver, Jason R.B. Dyck, Gary D. Lopaschuk
Cardiac glucose oxidation is decreased in heart failure with reduced ejection fraction (HFrEF), contributing to a decrease in myocardial ATP production. In contrast, circulating ketones and cardiac ketone oxidation are increased in HFrEF. Since ketones compete with glucose as a fuel source, we aimed to determine whether increasing ketone concentration both chronically with the SGLT2 inhibitor, dapagliflozin
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Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia? Metabolism (IF 9.8) Pub Date : 2024-02-15 Lucas B.R. Orssatto, Jacob R. Thorstensen, David Scott, Robin M. Daly
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Nonlinear relationship between high-density lipoprotein cholesterol and cardiovascular disease: an observational and Mendelian randomization analysis Metabolism (IF 9.8) Pub Date : 2024-02-15 Jun-Xiang Chen, Yue Li, Yan-Bo Zhang, Yi Wang, Yan-Feng Zhou, Tingting Geng, Gang Liu, An Pan, Yun-Fei Liao
Clinical trials and Mendelian randomization (MR) studies reported null effects of high-density lipoprotein cholesterol (HDL-C) on risk of cardiovascular disease (CVD), which might have overlooked a nonlinear causal association. We aimed to investigate the dose-response relationship between circulating HDL-C concentrations and CVD in observational and MR frameworks. We included 348,636 participants
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Mortality risk in patients with obesity and COVID-19 infection: a systematic review and meta-analysis Metabolism (IF 9.8) Pub Date : 2024-02-13 Haber Rachelle, Ghezzawi Malak, Puzantian Houry, Haber Marc, Saad Sacha, Ghandour Yara, El Bachour Joseph, Yazbeck Anthony, Hassanieh Ghinwa, Mehdi Celine, Ismail Dima, Abi-Kharma Elias, El-Zein Ola, Khamis Assem, Chakhtoura Marlene, Mantzoros Christos
Obesity is a risk factor for severe respiratory diseases, including COVID-19 infection. Meta-analyses on mortality risk were inconsistent.
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Autophagy and the unfolded protein response shape the non-alcoholic fatty liver landscape: decoding the labyrinth Metabolism (IF 9.8) Pub Date : 2024-02-02 Zahra Dashti, Zeynab Yousefi, Pouria Kiani, Motahareh Taghizadeh, Mohammad Hasan Maleki, Mohammad Borji, Omid Vakili, Sayed Mohammad Shafiee
The incidence of nonalcoholic fatty liver disease (NAFLD) is on the rise, mirroring a global surge in diabetes and metabolic syndrome, as its major leading causes. NAFLD represents a spectrum of liver disorders, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), which can potentially progress to cirrhosis and hepatocellular carcinoma (HCC). Mechanistically, we know
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Corrigendum to “Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma” [Metabolism, Volume 152, March 2024, 155771] Metabolism (IF 9.8) Pub Date : 2024-02-02 Sharmeen Ishteyaque, Gurvinder Singh, Karan Singh Yadav, Smriti Verma, Rakesh Kumar Sharma, Sumati Sen, Anurag Kumar Srivastav, Kalyan Mitr, Amit Lahiri, Dnyaneshwar U. Bawankule, Srikanta Kumar Rath, Dinesh Kumar, Madhav Nilakanth Mugale
Abstract not available
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Intermittent fasting protects β-cell identity and function in a type-2 diabetes model Metabolism (IF 9.8) Pub Date : 2024-02-01 Sumit Patel, Zihan Yan, Maria S. Remedi
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The risk and benefit of revisional vs. primary metabolic- bariatric surgery and drug therapy - A narrative review Metabolism (IF 9.8) Pub Date : 2024-01-27 Sebastian Nedelcut, Stephan Axer, Torsten Olbers
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Identification of MGMT promoter methylation as a specific lipid metabolism biomarker, reveals the feasibility of atorvastatin application in glioblastoma Metabolism (IF 9.8) Pub Date : 2024-01-30 Zhaonian Hao, Jiejun Wang, Yifan Lv, Weiqi Wu, Shaodong Zhang, Shuyu Hao, Junsheng Chu, Hong Wan, Jie Feng, Nan Ji
Glioblastoma is one of the deadliest tumors, and limited improvement in managing glioblastoma has been achieved in the past decades. The unmethylated promoter area of 6-O-Methylguanine-DNA Methyltransferase (MGMT) is a significant biomarker for recognizing a subset of glioblastoma that is resistant to chemotherapy. Here we identified MGMT methylation can also work as a specific biomarker to classify
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LAT1-dependent placental methionine uptake is a key player in fetal programming of metabolic disease Metabolism (IF 9.8) Pub Date : 2024-01-29 Mariana Schroeder, Barbara Fuenzalida, Nan Yi, Saira Shahnawaz, Jürg Gertsch, Daniele Pellegata, Edgar Ontsouka, Andrea Leiva, Jaime Gutiérrez, Martin Müller, Marcela A. Brocco, Christiane Albrecht
The Developmental Origins of Health and Disease hypothesis sustains that exposure to different stressors during prenatal development prepares the offspring for the challenges to be encountered after birth. We studied the gestational period as a particularly vulnerable window where different stressors can have strong implications for fetal programming of the offspring's life-long metabolic status via
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Dysregulation of autophagy activation induced by atorvastatin contributes to new-onset diabetes mellitus in western diet-fed mice Metabolism (IF 9.8) Pub Date : 2024-01-20 Juhee Kim, Minjune Kim, Minjeong Kim, Young-Hye You, Youngmi Song, Byung-Wan Lee
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Steatotic liver disease predicts cardiovascular disease and advanced liver fibrosis: A community-dwelling cohort study with 20-year follow-up Metabolism (IF 9.8) Pub Date : 2024-01-22 Hun Jee Choe, Joon Ho Moon, Won Kim, Bo Kyung Koo, Nam H. Cho
Background Steatotic liver disease (SLD) has emerged as new nomenclature to increase awareness and reflect the pathophysiology of the disease better. We investigated the risk of advanced fibrosis and cardiovascular disease (CVD) in SLD using data derived from a Korean prospective cohort. Methods We defined SLD using the fatty liver index (FLI) and identified advanced fibrosis with the age-adjusted
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Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice Metabolism (IF 9.8) Pub Date : 2024-01-21 Motoharu Awazawa, Maya Matsushita, Ikumi Nomura, Naoki Kobayashi, Miwa Tamura-Nakano, Yuriko Sorimachi, Keiyo Takubo, Kohjiro Ueki
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Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction Metabolism (IF 9.8) Pub Date : 2024-01-14 Daniela Rosendo-Silva, Pedro Bastos Gomes, Tiago Rodrigues, Sofia Viana, André Nogueira da Costa, Philipp E. Scherer, Flávio Reis, Francisco Pereira, Raquel Seiça, Paulo Matafome
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Empowering mitochondrial metabolism: Exploring L-lactate supplementation as a promising therapeutic approach for metabolic syndrome Metabolism (IF 9.8) Pub Date : 2024-01-11 Ming Cai, Shuyao Li, Keren Cai, Xinlin Du, Jia Han, Jingyun Hu
Mitochondrial dysfunction plays a critical role in the pathogenesis of metabolic syndrome (MetS), affecting various cell types and organs. In MetS animal models, mitochondria exhibit decreased quality control, characterized by abnormal morphological structure, impaired metabolic activity, reduced energy production, disrupted signaling cascades, and oxidative stress. The aberrant changes in mitochondrial
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Effect of sodium-glucose cotransporter-2 inhibitors on continuous glucose monitoring metrics, as adjunctive to insulin in adults with type 1 diabetes mellitus: a meta-analysis of randomized controlled trials Metabolism (IF 9.8) Pub Date : 2024-01-15 Djordje S. Popovic, Paschalis Karakasis, Theocharis Koufakis, Nikolaos Fragakis, Nikolaos Papanas, Milena Mitrovic, Evanthia Gouveri, Dimitrios Patoulias
Aims This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effect of sodium-glucose cotransporter-2 inhibitors (SGLT2is) on continuous glucose monitoring metrics as adjunctive to insulin in adults with type 1 diabetes mellitus (T1D). Methods A systematic literature search was conducted through Medline (via PubMed), Cochrane Library and Google Scholar until October 25, 2023
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A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation Metabolism (IF 9.8) Pub Date : 2024-01-15 Hao Wang, Lily Slotabec, Steven Didik, Zehui Li, Lin Leng, Bi Zhao, Richard Bucala, Ji Li
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Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study Metabolism (IF 9.8) Pub Date : 2024-01-13 Eugene Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Sang Hoon Ahn, Yong-ho Lee, Seung Up Kim
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Performance of non-invasive tests for liver fibrosis and resolution after bariatric surgery Metabolism (IF 9.8) Pub Date : 2024-01-12 Violeta Raverdy, Federica Tavaglione, Estelle Chatelain, Robert Caiazzo, Chiara Saponaro, Guillaume Lassailly, Helene Verkindt, Gregory Baud, Camille Marciniak, Mikael Chetboun, Naima Oukhouya-Daoud, Viviane Gnemmi, Emmanuelle Leteurtre, Alain Duhamel, Mathurin Philippe, Guillemette Marot, Stefano Romeo, François Pattou
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Minireview: Understanding and targeting inflammatory, hemodynamic and injury markers for cardiorenal protection in type 1 diabetes Metabolism (IF 9.8) Pub Date : 2024-01-11 Luxcia Kugathasan, Vikas S. Sridhar, Kalie L. Tommerdahl, Cheng Xu, Petter Bjornstad, Andrew Advani, David Z.I. Cherney
The coexistence of cardiovascular disease (CVD) and diabetic kidney disease (DKD) is common in people with type 1 diabetes (T1D) and is strongly associated with an increased risk of morbidity and mortality. Hence, it is imperative to explore robust tools that can accurately reflect the development and progression of cardiorenal complications. Several cardiovascular and kidney biomarkers have been identified
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Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy Metabolism (IF 9.8) Pub Date : 2024-01-10 Jing Yang, Yuxin Yan, Xiya Yin, Xiangqi Liu, Igor V. Reshetov, Pavel A. Karalkin, Qingfeng Li, Ru-Lin Huang
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Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner Metabolism (IF 9.8) Pub Date : 2024-01-09 Meiyao Meng, Yuxiang Cao, Jin Qiu, Guangyu Shan, Yingwen Wang, Ying Zheng, Mingwei Guo, Jian Yu, Yuandi Ma, Cen Xie, Cheng Hu, Lingyan Xu, Elisabetta Mueller, Xinran Ma
Background and aim Triglyceride (TG) levels are closely related to obesity, fatty liver and cardiovascular diseases, while the regulatory factors and mechanism for triglyceride homeostasis are still largely unknown. Zinc Finger Protein 638 (ZNF638) is a newly discovered member of zinc finger protein family for adipocyte function in vitro. The aim of the present work was to investigate the role of ZNF638
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Inhibition of PCSK9 prevents and alleviates cholesterol gallstones through PPARα-mediated CYP7A1 activation Metabolism (IF 9.8) Pub Date : 2024-01-06 Zhenmei Chen, Weiqing Shao, Yitong Li, Xiandi Zhang, Yan Geng, Xiaochen Ma, Baorui Tao, Yue Ma, Chenhe Yi, Bo Zhang, Rui Zhang, Jing Lin, Jinhong Chen
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Bariatric surgery, through beneficial effects on underlying mechanisms, improves cardiorenal and liver metabolic risk over an average of ten years of observation: a longitudinal and a case-control study Metabolism (IF 9.8) Pub Date : 2024-01-03 Alexander Kokkinos, Dimitrios Tsilingiris, Stamatia Simati, Konstantinos Stefanakis, Angeliki M. Angelidi, Nikolaos Tentolouris, Ioanna A. Anastasiou, Margery A. Connelly, Andreas Alexandrou, Christos S. Mantzoros
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Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma Metabolism (IF 9.8) Pub Date : 2024-01-05 Sharmeen Ishteyaque, Gurvinder Singh, Karan Singh Yadav, Smriti Verma, Rakesh Kumar Sharma, Sumati Sen, Anurag Kumar Srivastava, Kalyan Mitra, Amit Lahiri, Dnyaneshwar U. Bawankule, Srikanta Kumar Rath, Dinesh Kumar, Madhav Nilakanth Mugale
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GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway Metabolism (IF 9.8) Pub Date : 2024-01-03 Javier Jurado-Aguilar, Emma Barroso, Maribel Bernard, Meijian Zhang, Mona Peyman, Patricia Rada, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Introduction The levels of the cellular energy sensor AMP-activated protein kinase (AMPK) have been reported to be decreased via unknown mechanisms in the liver of mice deficient in growth differentiation factor 15 (GDF15). This stress response cytokine regulates energy metabolism mainly by reducing food intake through its hindbrain receptor GFRAL. Objective To examine how GDF15 regulates AMPK. Methods
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TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics Metabolism (IF 9.8) Pub Date : 2023-12-26 Jia Liu, Xiaogang Bao, Jian Huang, Rukun Chen, Yixuan Tan, Zheng Zhang, Bing Xiao, Fanqi Kong, Changjiang Gu, Jianhang Du, Haotian Wang, Junqiang Qi, Junming Tan, Duan Ma, Changgui Shi, Guohua Xu
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Photoperiod and metabolic health: evidence, mechanism, and implications Metabolism (IF 9.8) Pub Date : 2023-12-29 Prashant Regmi, Morag Young, Gabriela Minigo, Natalie Milic, Prajwal Gyawali
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Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease Metabolism (IF 9.8) Pub Date : 2023-12-27 Jiang Du, Xiang Ji, Bo Xu, Qizhang Du, Yujie Li, Bing Zhou, Xinlei Liu, Zhihao Xu, Yan Jiang, Beilin Kou, Zexin Li, Chaochu Cui, Juntang Lin
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Impact of fasting on the AMPK and PGC-1α axis in rodent and human skeletal muscle: A systematic review Metabolism (IF 9.8) Pub Date : 2023-12-27 K.L. Storoschuk, D. Lesiuk, J. Nuttall, M. LeBouedec, A. Khansari, H. Islam, B.J. Gurd
Based primarily on evidence from rodent models fasting is currently believed to improve metabolic health via activation of the AMPK-PGC-1α axis in skeletal muscle. However, it is unclear whether the skeletal muscle AMPK-PGC-1α axis is activated by fasting in humans. The current systematic review examined the fasting response in skeletal muscle from 34 selected studies (7 human, 21 mouse, and 6 rat)
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TOX3 deficiency mitigates hyperglycemia by suppressing hepatic gluconeogenesis through FoxO1 Metabolism (IF 9.8) Pub Date : 2023-12-23 Congcong Liu, Yuanwen Zheng, Shourui Hu, Xiaofan Liang, Yuxuan Li, Zhiheng Yu, Yue Liu, Yuehong Bian, Yuanyuan Man, Shigang Zhao, Xin Liu, Hongbin Liu, Tao Huang, Jinlong Ma, Zi-Jiang Chen, Han Zhao, Yuqing Zhang
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Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD Metabolism (IF 9.8) Pub Date : 2023-12-23 Juan Carlos Bórquez, Francisco Díaz-Castro, Francisco Pino-de La Fuente, Karla Espinoza, Ana María Figueroa, Inma Martínez-Ruíz, Vanessa Hernández, Iliana López-Soldado, Raúl Ventura, Joan Carles Domingo, Marta Bosch, Alba Fajardo, David Sebastián, Alejandra Espinosa, Albert Pol, Antonio Zorzano, Víctor Cortés, María Isabel Hernández-Alvarez, Rodrigo Troncoso
Background and aim The excessive accumulation of lipid droplets (LDs) is a defining characteristic of nonalcoholic fatty liver disease (NAFLD). The interaction between LDs and mitochondria is functionally important for lipid metabolism homeostasis. Exercise improves NAFLD, but it is not known if it has an effect on hepatic LD-mitochondria interactions. Here, we investigated the influence of exercise
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Barriers to metabolic surgery and how to address them Metabolism (IF 9.8) Pub Date : 2023-12-21 Martine Laville, Maud Robert, Bérénice Segrestin
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Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in metabolic dysfunction-associated steatotic liver disease Metabolism (IF 9.8) Pub Date : 2023-12-19 Theresia Sarabhai, Sabine Kahl, Sofiya Gancheva, Lucia Mastrototaro, Bedair Dewidar, Dominik Pesta, Jacqueline M. Ratter-Rieck, Pavel Bobrov, Kay Jeruschke, Irene Esposito, Matthias Schlensak, Michael Roden
Background Obesity and type 2 diabetes frequently have metabolic dysfunction-associated steatotic liver disease (MASLD) including steatohepatitis (MASH). In obesity, the liver may adapt its oxidative capacity, but the role of mitochondrial turnover in MASLD remains uncertain. Methods This cross-sectional study compared individuals with class III obesity (n = 8/group) without (control, OBE CON; NAFLD
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Diabetic kidney disease in type 1 diabetes: Challenges and differences from type 2 diabetes Metabolism (IF 9.8) Pub Date : 2023-12-19 Djordje S. Popovic, Dimitrios Patoulias, Luigi Gnudi, Christos S. Mantzoros
Abstract not available
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Mitochondrial ribosomal protein L12 potentiates hepatocellular carcinoma by regulating mitochondrial biogenesis and metabolic reprogramming Metabolism (IF 9.8) Pub Date : 2023-12-15 Xingzhao Ji, Zhen Yang, Chensheng Li, Suwei Zhu, Yu Zhang, Fuyuan Xue, Shengnan Sun, Tingting Fu, Can Ding, Yi Liu, Qiang Wan
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Plasma proteome profiling reveals metabolic and immunologic differences between Anorexia Nervosa subtypes Metabolism (IF 9.8) Pub Date : 2023-12-15 Diana Samodova, August Hoel, Tue Haldor Hansen, Loa Clausen, Gry Kjaersdam Telléus, Hans-Peter Marti, Oluf Pedersen, Rene Klinkby Støving, Atul Shahaji Deshmukh
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Markers of adipose tissue fibrogenesis associate with clinically significant liver fibrosis and are unchanged by synbiotic treatment in patients with NAFLD Metabolism (IF 9.8) Pub Date : 2023-12-13 Josh Bilson, Carolina J. Oquendo, James Read, Eleonora Scorletti, Paul R. Afolabi, Jenny Lord, Laure B. Bindels, Giovanni Targher, Sumeet Mahajan, Diana Baralle, Philip C. Calder, Christopher D. Byrne, Jaswinder K. Sethi
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The role of ROS in tumor infiltrating immune cells and cancer immunotherapy Metabolism (IF 9.8) Pub Date : 2023-11-30 Rushil Shah, Betul Ibis, Monisha Kashyap, Vassiliki A. Boussiotis
Reactive oxygen species (ROS) are a group of short-lived highly reactive molecules formed intracellularly from molecular oxygen. ROS can alter biochemical, transcriptional, and epigenetic programs and have an indispensable role in cellular function. In immune cells, ROS are mediators of specialized functions such as phagocytosis, antigen presentation, activation, cytolysis, and differentiation. ROS
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Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss Metabolism (IF 9.8) Pub Date : 2023-11-26 Sujin Park, Jin Sun Heo, Seiya Mizuno, Minwoo Kim, Haein An, Eunji Hong, Min Gi Kang, Junil Kim, Rebecca Yun, Hyeyeon Park, Eun Hye Noh, Min Jung Lee, Kwiyeom Yoon, Pyunggang Kim, Minjung Son, Kyoungwha Pang, Jihee Lee, Jinah Park, Akira Ooshima, Tae-Jin Kim, Seong-Jin Kim
Background Multinucleation is a hallmark of osteoclast formation and has a unique ability to resorb bone matrix. During osteoclast differentiation, the cytoskeleton reorganization results in the generation of actin belts and eventual bone resorption. Tetraspanins are involved in adhesion, migration and fusion in various cells. However, its function in osteoclast is still unclear. In this study, we
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Bariatric Surgery in Women with Polycystic Ovary Syndrome Metabolism (IF 9.8) Pub Date : 2023-11-28 Suhaniya N.S. Samarasinghe, Casper Woods, Alexander Dimitri Miras
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant proportion of women with PCOS and is strongly implicated in the pathophysiology of the disease. Both PCOS and obesity are known to impact fertility in women; obesity
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Rising global burden of cancer attributable to high BMI from 2010 to 2019 Metabolism (IF 9.8) Pub Date : 2023-11-27 Darren Jun Hao Tan, Cheng Han Ng, Mark Muthiah, Jie Ning Yong, Douglas Chee, Margaret Teng, Zhen Yu Wong, Rebecca Wenling Zeng, Yip Han Chin, Jiong-Wei Wang, Pojsakorn Danpanichkul, Ruveena Bhavani Rajaram, Ramanuj DasGupta, Hiroyuki Suzuki, Hirokazu Takahashi, Nobuharu Tamaki, Yock Young Dan, Rashid Lui, Ajay Duseja, Mohammad Shadab Siddiqui, Daniel Q. Huang
Background High body mass index (BMI) is a major risk factor for cancer development, but its impact on the global burden of cancer remains unclear. Methods We estimated global and regional temporal trends in the burden of cancer attributable to high BMI, and the contributions of various cancer types using the framework of the Global Burden of Disease Study. Results From 2010 to 2019, there was a 35 %
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Plasma metabolite predictors of metabolic syndrome incidence and reversion Metabolism (IF 9.8) Pub Date : 2023-11-24 Zhila Semnani-Azad, Estefanía Toledo, Nancy Babio, Miguel Ruiz-Canela, Clemens Wittenbecher, Cristina Razquin, Fenglei Wang, Courtney Dennis, Amy Deik, Clary B. Clish, Dolores Corella, Montserrat Fitó, Ramon Estruch, Fernando Arós, Emilio Ros, Jesús García-Gavilan, Liming Liang, Jordi Salas-Salvadó, Miguel A. Martínez-González, Frank B. Hu, Marta Guasch-Ferré
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Intestinal glucose excretion: A potential mechanism for glycemic control Metabolism (IF 9.8) Pub Date : 2023-11-24 Zhigang Ke, Zongshi Lu, Qing Li, Weidong Tong
The gut has been increasingly recognized in recent years as a pivotal organ in the maintenance of glucose homeostasis. Specifically, the profound and enduring improvement in glucose metabolism achieved through metabolic surgery to modify the anatomy of the gut has prompted scholars to acknowledge that the most effective strategy for treating type 2 diabetes mellitus (T2DM) involves the gut. The mechanisms
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Towards personalized genome-scale modeling of inborn errors of metabolism for systems medicine applications Metabolism (IF 9.8) Pub Date : 2023-11-18 Almut Heinken, Sandra El Kouche, Rosa-Maria Guéant-Rodriguez, Jean-Louis Guéant
Inborn errors of metabolism (IEMs) are a group of more than 1000 inherited diseases that are individually rare but have a cumulative global prevalence of 50 per 100,000 births. Recently, it has been recognized that like common diseases, patients with rare diseases can greatly vary in the manifestation and severity of symptoms. Here, we review omics-driven approaches that enable an integrated, holistic
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Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond Metabolism (IF 9.8) Pub Date : 2023-11-22 Dimitrios Tsilingiris, Alexander Kokkinos
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Gut-derived ammonia contributes to alcohol-related fatty liver development via facilitating ethanol metabolism and provoking ATF4-dependent de novo lipogenesis activation Metabolism (IF 9.8) Pub Date : 2023-11-22 Qing Song, Chueh-Lung Hwang, Yanhui Li, Jun Wang, Jooman Park, Samuel M. Lee, Zhaoli Sun, Jun Sun, Yinglin Xia, Natalia Nieto, Jose Cordoba-Chacon, Yuwei Jiang, Xiaobing Dou, Zhenyuan Song
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Addressing uncertainty about the role of structured lifestyle modification for metabolic surgery patients Metabolism (IF 9.8) Pub Date : 2023-11-18 Enda Murphy, Francis M. Finucane
There is good evidence that structured lifestyle modification programmes improve health in patients with metabolic and cardiovascular disorders, but there is no specific evidence that they improve outcomes in patients undergoing metabolic or obesity surgery. Despite expert consensus guidelines stating this fact, some healthcare systems still compel patients to participate in a structured lifestyle
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PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease Metabolism (IF 9.8) Pub Date : 2023-11-13 Vatsal Sachan, Maïlys Le Dévéhat, Anna Roubtsova, Rachid Essalmani, Jean-Francois Laurendeau, Damien Garçon, Delia Susan-Resiga, Stéphanie Duval, Sahar Mikaeeli, Josée Hamelin, Alexandra Evagelidis, Michael Chong, Guillaume Paré, Elizabeta Chernetsova, Zu-Hua Gao, Isabelle Robillard, Matthieu Ruiz, Vincent Quoc-Huy Trinh, Jennifer L. Estall, May Faraj, Nabil G. Seidah
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CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease Metabolism (IF 9.8) Pub Date : 2023-11-11 Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
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Sarcopenia: still in relative definition-penia and severe treatment-penia Metabolism (IF 9.8) Pub Date : 2023-11-03 Stergios A. Polyzos, Christos S. Mantzoros
Abstract not available
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Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4 Metabolism (IF 9.8) Pub Date : 2023-11-06 Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
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Recent research advances in metabolism, clinical and experimental Metabolism (IF 9.8) Pub Date : 2023-11-04 Chrysoula Boutari, Michail Kokkorakis, Konstantinos Stefanakis, Laura Valenzuela-Vallejo, Evangelos Axarloglou, Spela Volkansek, Marlene Chakhtoura, Christos S. Mantzoros
Abstract not available