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The underlying roles and neurobiological mechanisms of Music-Based Intervention in Alzheimer's disease: A comprehensive review Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-12 Liyang Sun, Qin Wang, Jing Ai
Non-pharmacological therapy has gained popularity in the intervention of Alzheimer's disease (AD) due to its apparent therapeutic effectiveness and the limitation of biological drug. A wealth of research indicates that music interventions can enhance cognition, mood and behavior in individuals with AD. Nonetheless, the underlying mechanisms behind these improvements have yet to be fully and systematically
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The efficacy of dyadic interventions for community-dwelling people with dementia and their caregivers: a systematic review and meta-analysis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-12 Balvert Sanne C.E., Del Sordo Giovanna C, Milders Maarten V
Most people with dementia live at home and depend on informal caregivers for care. Both caregivers and persons with dementia can experience negative psychological and behavioural effects as the disease progresses. Non-pharmacological interventions can alleviate these effects and dyadic interventions, involving both caregiver and person with dementia, may be particularly effective.
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Agmatine as a Novel Intervention for Alzheimer's Disease: Pathological Insights and Cognitive Benefits Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-11 Raj A. Katariya, Shivkumar S. Sammeta, Mayur B. Kale, Nandkishor R. Kotagale, Milind J. Umekar, Brijesh G. Taksande
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and a significant societal burden. Despite extensive research and efforts of the multidisciplinary scientific community, to date, there is no cure for this debilitating disease. Moreover, the existing pharmacotherapy for AD only provides symptomatic support and does not modify the course
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Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-09 Gregory Livshits, Alexander Kalinkovich
Sarcopenia is an age-associated loss of skeletal muscle mass, strength, and function, accompanied by severe adverse health outcomes, such as falls and fractures, functional decline, high health costs, and mortality. Hence, its prevention and treatment have become increasingly urgent. However, despite the wide prevalence and extensive research on sarcopenia, no FDA-approved disease-modifying drugs exist
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Estimated prevalence of frailty and prefrailty in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and proportional meta-analysis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-09 Cathy W.Y. Wong, Polly W.C. Li, Doris S.F. Yu, Benjamin M.H. Ho, Bernice Shinyi Chan
The aging population has led to an increasing number of older patients undergoing cardiac surgeries/procedures. Frailty and prefrailty have emerged as important prognostic indicators among these patients. This proportional meta-analysis estimated the prevalence of frailty and prefrailty among patients undergoing cardiac surgery. We searched seven electronic databases for observational studies that
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Aging phenotype in AD brain organoids: Track to success and challenges Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-07 Muhammad Kamal Hossain, Hyung-Ryong Kim, Han Jung Chae
Alzheimer's disease (AD) poses a complex challenge, with abnormal protein accumulation in the brain causing memory loss and cognitive decline. Traditional models fall short in AD research, prompting interest in 3D brain organoids (BOs) from human stem cells. These findings hold promise for unveiling the mechanisms of AD, especially in relation to aging. However, an understanding of the aging impact
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Organ-specific biological clocks: Ageotyping for personalized anti-aging medicine Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-04 Francesco Prattichizzo, Chiara Frigé, Valeria Pellegrini, Lucia Scisciola, Aurelia Santoro, Daniela Monti, Maria Rita Rippo, Mikhail Ivanchenko, Fabiola Olivieri, Claudio Franceschi
Aging is a complex multidimensional, progressive remodeling process affecting multiple organ systems. While many studies have focused on studying aging across multiple organs, assessment of the contribution of individual organs to overall aging processes is a cutting-edge issue. An organ’s biological age might influence the aging of other organs, revealing a multiorgan aging network. Recent data demonstrated
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Effects of clitorienolactones from Clitoria ternatea root on calcium channel mediating hippocampal long-term potentiation in rats induced chronic cerebral hypoperfusion Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-03 Mohamad Anuar Ahad, Nelson Jeng-Yeou Chear, Muhammad Hazim Abdullah, Tan Ai Fein Ching-Ga, Ping Liao, Shunhui Wei, Vikneswaran Murugaiyah, Zurina Hassan
Chronic cerebral hypoperfusion (CCH) is a common mechanism of acute brain injury due to impairment of blood flow to the brain. Moreover, a prolonged lack of oxygen supply may result in cerebral infarction or global ischemia, which subsequently causes long-term memory impairment. Research on using root extract for treating long-term memory has been studied extensively. However, the bioactive compound
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Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: can we develop a clinically relevant composite combination? Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-02 Angela Marie Abbatecola, Angelica Giuliani, Leonardo Biscetti, Lucia Scisciola, Petronilla Battista, Michelangela Barbieri, Jacopo Sabbatinelli, Fabiola Olivieri
Alzheimer's disease (AD) is a rapidly growing global concern due to a consistent rise of the prevalence of dementia which is mainly caused by the aging population worldwide. An early diagnosis of AD remains important as interventions are plausibly more effective when started at the earliest stages. Recent developments in clinical research have focused on the use of blood-based biomarkers for improve
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Associations of environmental factors with neurodegeneration: An exposome-wide Mendelian randomization investigation Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-29 Dun Li, Lihui Zhou, Zhi Cao, Jida Wang, Hongxi Yang, Mingqian Lyu, Yuan Zhang, Rongrong Yang, Ju Wang, Yuhong Bian, Weili Xu, Yaogang Wang
Neurodegenerative diseases (NDDs) remain a global health challenge. Previous studies have reported potential links between environmental factors and NDDs, however, findings remain controversial across studies and elusive to be interpreted as evidence of robust causal associations. In this study, we comprehensively explored the causal associations of the common environmental factors with major NDDs
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Involvement of regulated cell deaths in aging and age-related pathologies Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-28 Laura Della Torre, Antonio Beato, Vincenza Capone, Daniela Carannante, Giulia Verrilli, Gregorio Favale, Nunzio Del Gaudio, Wouter Leonard Megchelenbrink, Rosaria Benedetti, Lucia Altucci, Vincenzo Carafa
Aging is a pathophysiological process that causes a gradual and permanent reduction in all biological system functions. The phenomenon is caused by the accumulation of endogenous and exogenous damage as a result of several stressors, resulting in significantly increased risks of various age-related diseases such as neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal
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Mechanisms of pain in aging and age-related conditions: Focus on caregivers Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-27 Peyton Presto, Ujala Sehar, Jonathan Kopel, P. Hemachandra Reddy
Pain is a complex, subjective experience that can significantly impact quality of life, particularly in aging individuals, by adversely affecting physical and emotional well-being. Whereas acute pain usually serves a protective function, chronic pain is a persistent pathological condition that contributes to functional deficits, cognitive decline, and emotional disturbances in the elderly. Despite
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Blood-based biomarkers of cerebral small vessel disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-27 Liu-Yun Wu, Yuek Ling Chai, Irwin K. Cheah, Rachel S.L. Chia, Saima Hilal, Thiruma V. Arumugam, Christopher P. Chen, Mitchell K.P. Lai
Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous condition, arising from diverse microvascular mechanisms. These lead to chronic cerebrovascular dysfunction and carry a substantial risk of subsequent stroke and vascular cognitive impairment in aging populations. Owing to advances in neuroimaging, visualization of cerebral vasculature abnormities and detection
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Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-26 Francisco Irochima Pinheiro, Irami Araújo-Filho, Amália Cinthia Meneses do Rego, Eduardo Pereira de Azevedo, Ricardo Ney Cobucci, Fausto Pierdona Guzen
Dementia has been faced with significant public health challenges and economic burdens that urges the need to develop safe and effective interventions. In recent years, an increasing number of studies have focused on the relationship between dementia and liver and pancreatic metabolic disorders that result in diseases such as diabetes, obesity, hypertension and dyslipidemia. Previous reports have shown
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The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-24 Yang Su, Ningrui Cao, Dingkun Zhang, Minjin Wang
Temporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been established that due to its complex pathogenesis, a considerable proportion of TLE patients often progress to drug-resistant epilepsy. Ferroptosis has emerged as an important neuronal death mechanism in TLE, which is primarily influenced by lipid accumulation and oxidative stress. In previous studies of ferroptosis
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Understanding age-related pathologic changes in TDP-43 functions and their consequence on RNA splicing and signalling in health and disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-23 Flora Cheng, Tyler Chapman, Selina Zhang, Marco Morsch, Roger Chung, Albert Lee, Stephanie L. Rayner
TAR DNA binding protein-43 (TDP-43) is a key component in RNA splicing which plays a crucial role in the aging process In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Limbic-predominant age-related TDP-43 Encephalopathy (LATE), TDP-43 can be mutated, mislocalised out of the nucleus of neurons and glial cells and form cytoplasmic inclusions
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Multiomics insights into the female reproductive aging Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-23 Simin Wei, Weicheng Tang, Dan Chen, Jiaqiang Xiong, Liru Xue, Yun Dai, Yican Guo, Chuqing Wu, Jun Dai, Meng Wu, Shixuan Wang
The human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed aging in the female reproductive system remain elusive. Recent advancements in omics technologies and computational capabilities
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A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-22 Xinyue Tang, Zixuan Guo, Guanmao Chen, Shilin Sun, Shu Xiao, Pan Chen, Guixian Tang, Li Huang, Ying Wang
Numerous neuroimaging studies have reported that Alzheimer's disease (AD) spectrum have been linked to alterations in intrinsic functional activity and cortical thickness (CT) of some brain areas. However, the findings have been inconsistent and the correlation with the transcriptional profile and neurotransmitter systems remain largely unknown. We conducted a meta-analysis to identify multimodal differences
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The measurement properties and feasibility of FRAIL scale in older adults: A systematic review and meta-analysis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-21 Yu Xuan NG, Ling Jie CHENG, Yu Yi QUEK, Ruby YU, Xi Vivien WU
Frailty is a prevalent condition amongst older adults, significantly affecting their quality of life. The FRAIL tool has been purposefully designed for clinical application by assisting healthcare professionals in identifying and managing frailty-related issues in older adults, making it a preferred choice for assessing frailty across diverse older populations. This review aimed to synthesize the measurement
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Role of succinylation modification in central nervous system diseases Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-21 Chao Wang, Weigang Cui, Bing Yu, Han Zhou, Zhenwen Cui, Pin Guo, Tao Yu, Yugong Feng
Diseases of the central nervous system (CNS), including stroke, brain tumors, and neurodegenerative diseases, have a serious impact on human health worldwide, especially in elderly patients. The brain, which is one of the body's most metabolically dynamic organs, lacks fuel stores and therefore requires a continuous supply of energy substrates. Metabolic abnormalities are closely associated with the
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Vitamin D and ischemic stroke - association, mechanisms, and therapeutics Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-21 Pan Cui, Haiman Hou, Bo Song, Zongping Xia, Yuming Xu
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Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-21 Xin Huang, Weiyue Zhang
Arthritis has become the most common joint disease globally. Current attention has shifted towards preventing the disease and exploring pharmaceutical and surgical treatments for early-stage arthritis. M2 macrophages are known for their anti-inflammatory properties and their ability to support cartilage repair, offering relief from arthritis. Whereas, it remains a great challenge to promote the beneficial
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Therapeutic effect of dietary ingredients on cellular senescence in animals and humans: A systematic review Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-19 Lihuan Guan, Anna Eisenmenger, Karen C. Crasta, Elena Sandalova, Andrea B. Maier
Cellular senescence has been regarded as a therapeutic target for ageing and age-related diseases. Several senotherapeutic agents have been proposed, including compounds derived from natural products which hold the translational potential to promote healthy ageing. This systematic review examined the association of dietary ingredients with cellular senescence in animals and humans, with an intent to
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Social determinants of intrinsic capacity: A systematic review of observational studies Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-19 Zi-Ting Huang, Eric T.C. Lai, Yan Luo, Jean Woo
The World Health Organization defined healthy ageing as the maintenance of functional ability with ageing. Intrinsic capacity is a measurement of healthy ageing, and can be shaped by social determinants. However, an overall understanding of how multiple social determinants contribute to intrinsic capacity remains unclear. We aim to summarize observational studies investigating the relationships between
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Efficacy of deprescribing on health outcomes: An umbrella review of systematic reviews with meta-analysis of randomized controlled trials Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-16 Nicola Veronese, Umberto Gallo, Virginia Boccardi, Jacopo Demurtas, Alberto Michielon, Xhoajda Taci, Giulia Zanchetta, Sophia Elizabeth Campbell Davis, Marco Chiumente, Francesca Venturini, Alberto Pilotto
Deprescribing is an important intervention across different settings in medicine, but the literature supporting such a practice is still conflicting. Therefore, we aimed to capture the breadth of outcomes reported and assess the strength of evidence of the use of deprescribing for health outcomes. Umbrella review of systematic reviews of the use of deprescribing searching in Medline, Scopus, and Web
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The role and mechanism of RNA-binding proteins in bone metabolism and osteoporosis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-16 Jiaqiang Wu, Liyan Niu, Kangping Yang, Jingdong Xu, Deju Zhang, Jitao Ling, Panpan Xia, Yuting Wu, Xiao Liu, Jianping Liu, Jing Zhang, Peng Yu
Osteoporosis is a prevalent chronic metabolic bone disease that poses a significant risk of fractures or mortality in elderly individuals. Its pathophysiological basis is often attributed to postmenopausal estrogen deficiency and natural aging, making the progression of primary osteoporosis among elderly people, especially older women, seemingly inevitable. The treatment and prevention of osteoporosis
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Epigenetic regulations of cellular senescence in osteoporosis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-16 Shaochuan Huo, Xinzheng Tang, Weijian Chen, Donghao Gan, Hai Guo, Qing Yao, Rongdong Liao, Tingting Huang, Junxian Wu, Junxing Yang, Guozhi Xiao, Xia Han
Osteoporosis (OP) is a prevalent age-related disease that is characterized by a decrease in bone mineral density (BMD) and systemic bone microarchitectural disorders. With age, senescent cells accumulate and exhibit the senescence-associated secretory phenotype (SASP) in bone tissue, leading to the imbalance of bone homeostasis, osteopenia, changes in trabecular bone structure, and increased bone fragility
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Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-16 Bushra Bashir, Shahbaz Alam, Nikhil Khandale, Devendra Birla, Sukriti Vishwas, Narendra Kumar Pandey, Gaurav Gupta, Keshav Raj Paudel, Harish Dureja, Puneet Kumar, Thakur Gurjeet Singh, Gowthamarajan Kuppusamy, Flavia C. Zacconi, Terezinha de Jesus Andreoli Pinto, Muralikrishnan Dhanasekaran, Monica Gulati, Kamal Dua, Sachin Kumar Singh
Recent studies have indicated the significant involvement of the gut microbiome in both human physiology and pathology. Additionally, therapeutic interventions based on microbiome approaches have been employed to enhance overall health and address various diseases including aging and neurodegenerative disease (ND). Researchers have explored potential links between these areas, investigating the potential
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Unveiling the future: Advancements in MRI imaging for neurodegenerative disorders Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-15 Lixin Du, Shubham Roy, Pan Wang, Zhigang Li, Xiaoting Qiu, Yinghe Zhang, Jianpeng Yuan, Bing Guo
Neurodegenerative disorders represent a significant and growing global health challenge, necessitating continuous advancements in diagnostic tools for accurate and early detection. This work explores the recent progress in Magnetic Resonance Imaging (MRI) techniques and their application in the realm of neurodegenerative disorders. The introductory section provides a comprehensive overview of the study's
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Lithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson’s disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-15 Monique Patricio Singulani, Ana Flávia Fernandes Ferreira, Paulina Sepúlveda Figueroa, Iván Cuyul-Vásquez, Leda Leme Talib, Luiz Roberto Britto, Orestes Vicente Forlenza
The role of lithium as a possible therapeutic strategy for neurodegenerative diseases has generated scientific interest. We systematically reviewed and meta-analyzed pre-clinical and clinical studies that evidenced the neuroprotective effects of lithium in Alzheimer's (AD) and Parkinson's disease (PD). We followed the PRISMA guidelines and performed the systematic literature search using PubMed, EMBASE
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Circadian regulation of microglia function: Potential targets for treatment of Parkinson’s Disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-15 Liang Kou, Xiaosa Chi, Yadi Sun, Sijia Yin, Jiawei Wu, Wenkai Zou, Yiming Wang, Zongjie Jin, Jinsha Huang, Nian Xiong, Yun Xia, Tao Wang
Circadian rhythms are involved in the regulation of many aspects of the body, including cell function, physical activity and disease. Circadian disturbance often predates the typical symptoms of neurodegenerative diseases and is not only a non-motor symptom, but also one of the causes of their occurrence and progression. Glial cells possess circadian clocks that regulate their function to maintain
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Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-15 Faizan Ahmad, Anik Karan, Rashi Sharma, Navatha Shree Sharma, Vaishnavi Sundar, Richard Jayaraj, Sudip Mukherjee, Mark A. DeCoster
Alzheimer’s Disease (AD) patients experience diverse symptoms, including memory loss, cognitive impairment, behavioral abnormalities, mood changes, and mental issues. The fundamental objective of this review is to discuss novel therapeutic approaches, with special emphasis on recently approved marketed formulations for the treatment of AD, especially Aducanumab, the first FDA approved moiety that surpasses
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Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-14 Hayder M. Al-kuraishy, Majid S. Jabir, Ali K. Albuhadily, Ali I. Al-Gareeb, Sabrean F. Jawad, Ayman A. Swelum, Najah R. Hadi
The ketogenic diet (KD) is a low-carbohydrate, adequate protein and high-fat diet. KD is primarily used to treat refractory epilepsy. KD was shown to be effective in treating different neurodegenerative diseases. Alzheimer disease (AD) is the first common neurodegenerative disease in the world characterized by memory and cognitive impairment. However, the underlying mechanism of KD in controlling of
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Sex biology in amyotrophic lateral sclerosis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-13 Akram Zamani, Emma Thomas, David K. Wright
Although sex differences in amyotrophic lateral sclerosis (ALS) have not been studied systematically, numerous clinical and preclinical studies have shown sex to be influential in disease prognosis. Moreover, with the development of advanced imaging tools, the difference between male and female brain in structure and function and their response to neurodegeneration are more definitive. As discussed
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Unveiling the impact of Aging on BBB and Alzheimer's disease: Factors and Therapeutic implications Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-10 Niraj Kumar Jha, Vinod Kumar Nelson, Mohana Vamsi Nuli, Sandeep Kanna, Reema M Gahtani, Umme Hani, Arun Kumar Singh, Saurabh Gupta, Mosleh Mohammad Abomughaid, Ali M Abomughayedh, Abdulmajeed G. Almutary, Danish Iqbal, Ayoub Al Othaim, S. Sabarunisha Begum, Fuzail Ahmad, Prabhu Chandra Mishra, Saurabh Kumar Jha, Shreesh Ojha
Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has devastating effects on individuals, often resulting in dementia. AD is primarily defined by the presence of extracellular plaques containing insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFT) composed of hyperphosphorylated tau protein (P-tau). In addition, individuals afflicted by these age-related
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Cosmic chronometers: Is spaceflight a catalyst for biological ageing? Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-10 Manuela Campisi, Luana Cannella, Sofia Pavanello
Astronauts returning from space missions often exhibit health issues mirroring age-related conditions, suggesting spaceflight as a potential driver of biological ageing and age-related diseases. To unravel the underlying mechanisms of these conditions, this comprehensive review explores the impact of the space “exposome” on the twelve hallmarks of ageing. Through a meticulous analysis encompassing
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Heterotopic mineralization (ossification or calcification) in aged musculoskeletal soft tissues: A new candidate marker for aging Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-05 Guang-Chun Dai, Hao Wang, Zhang Ming, Pan-Pan Lu, Ying-Juan Li, Yu-Cheng Gao, Liu Shi, Zhang Cheng, Xiao-Yu Liu, Yun-Feng Rui
Aging can lead to various disorders in organisms and with the escalating impact of population aging, the incidence of age-related diseases is steadily increasing. As a major risk factor for chronic illnesses in humans, the prevention and postponement of aging have become focal points of research among numerous scientists. Aging biomarkers, which mirror molecular alterations at diverse levels in organs
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Unveiling the role of astrocytes in postoperative cognitive dysfunction Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-05 Liang He, Xiyuan Duan, Shikuo Li, Ruqiang Zhang, Xulei Dai, Meilin Lu
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by progressive cognitive decline and the accumulation of amyloid-beta plaques, tau tangles, and neuroinflammation in the brain. Postoperative cognitive dysfunction (POCD) is a prevalent and debilitating condition characterized by cognitive decline following neuroinflammation and oxidative stress induced by procedures
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Pharmacological interventions in human aging Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-02 Michael Angelo Petr, Frida Matiyevskaya, Brenna Osborne, Magnus Berglind, Simon Reves, Bin Zhang, Michael Ben Ezra, Lina Maria Carmona-Marin, Muhammad Farraz Syadzha, Marta Cortés Mediavilla, Guido Keijzers, Daniela Bakula, Garik V Mkrtchyan, Morten Scheibye-Knudsen
Pharmacological interventions are emerging as potential avenues of alleviating age-related disease. However, the knowledge of ongoing clinical trials as they relate to aging and pharmacological interventions is dispersed across a variety of mediums. In this review we summarize 136 age-related clinical trials that have been completed or are ongoing. Furthermore, we establish a database that describe
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The mechanism of cuproptosis in Parkinson’s disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-02 Min Huang, Yong Zhang, Xuehong Liu
Parkinson’s disease (PD) is a neurodegenerative disease with an increased morbidity. The pathogenesis PD has not been fully elucidated, and whatever mechanism is involved, it ultimately leads to dopamine (DA) neuronal apoptosis. Cuproptosis is a novel form of cell death. Its morphology, biochemical properties, and mechanism of action differ from known forms of cell death, such as apoptosis, autophagy
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Breaking the links between ageism and health: An integrated perspective Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-01 Julie D. Henry, Sarah P. Coundouris, Matthew R. Nangle
Ageism refers to prejudice, stereotypes or discrimination based on a person’s actual or perceived chronological age. While ageism can affect people at all stages of the human lifespan, ageism against older adults has emerged as the most pervasive and potentially harmful. Much is now understood about how ageism can impact older people’s health and wellbeing via structural, organisational, and provider
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Psychedelics for Alzheimer's Disease-Related Dementia: Unveiling Therapeutic Possibilities and Pathways Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-01 Jitendra Kumar Sinha, Anchal Trisal, Shampa Ghosh, Saurabh Gupta, Krishna Kumar Singh, Sung Soo Han, Madhumita Mahapatra, Mosleh Mohammad Abomughaid, Ali M Abomughayedh, Abdulmajeed G. Almutary, Danish Iqbal, Rakesh Bhaskar, Abhishek Kumar Singh, Prabhu Chandra Mishra, Saurabh Kumar Jha, Niraj Kumar Jha
Psychedelics have traditionally been used for spiritual and recreational purposes, but recent developments in psychotherapy have highlighted their potential as therapeutic agents. These compounds, which act as potent 5-hydroxytryptamine (5HT) agonists, have been recognized for their ability to enhance neural plasticity through the activation of the serotoninergic and glutamatergic systems. However
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Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer's disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-01 Lorenza Guarnieri, Francesca Bosco, Antonio Leo, Rita Citraro, Ernesto Palma, Giovambattista De Sarro, Vincenzo Mollace
Alzheimer's disease (AD) is a major global health problem today and is the most common form of dementia. AD is characterized by the formation of β-amyloid (Aβ) plaques and neurofibrillary clusters, leading to decreased brain acetylcholine levels in the brain. Another mechanism underlying the pathogenesis of AD is the abnormal phosphorylation of tau protein that accumulates at the level of neurofibrillary
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An update on new-age potential biomarkers for Parkinson’s disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-29 Ritu Soni, Kirti Mathur, Jigna Shah
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New insight on the possible role of statins in Vascular Parkinsonism: A need for presumptive therapy Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-28 Hayder M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Ali K. Albuhadily
Vascular Parkinsonism (VP) is clinical term represents a progressive ischemic changes and subcortical lacunar infarct leading to Parkinsonism mainly in the lower limbs so called lower body Parkinsonism. The VP neuropathology is differed from that of PD neuropathology which rarely associated with basal ganglion lesions. Dopamine transporters are normal in VP but are highly reduced in PD, and dopaminergic
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Neural alterations underlying executive dysfunction in Parkinson’s disease: A systematic review and coordinate-based meta-analysis of functional neuroimaging studies. Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-26 Eleonora Arrigoni, Paola Antoniotti, Virginia Bellocchio, Laura Veronelli, Massimo Corbo, Alberto Pisoni
Parkinson’s Disease’s (PD) neuropsychological profile is often characterized by altered performance in executive functions (EF) tasks, with a remarkable impact on patients’ quality of life. To date, the available neuroimaging literature lacks conclusive evidence about neural patterns underlying EF deficits in PD. Here, we aimed to synthesize the results of PET/fMRI studies examining the differences
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Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-24 Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Irene Palacio, Elena Casero, Carmen Quintana, Jyoti Singh, Manoj Kumar Singh, Jose A. Martín Gago, Sunil Kumar Singh
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PARP1 at the crossroad of cellular senescence and nucleolar processes Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-24 Kinga Kołacz, Agnieszka Robaszkiewicz
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Epigenetic reprogramming as a key to reverse ageing and increase longevity Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-23 Beatriz Pereira, Francisca P. Correia, Inês A. Alves, Margarida Costa, Mariana Gameiro, Ana P. Martins, Jorge A. Saraiva
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Understanding the mechanisms of disease modifying effects of aerobic exercise in people with Alzheimer’s disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-23 Auwal Abdullahi, Thomson WL Wong, Shamay SM Ng
Alzheimer’s disease (AD) is a very disabling disease. Pathologically, it is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain that results in neurodegeneration. Its clinical manifestations include progressive memory impairment, language decline and difficulty in carrying out activities of daily living (ADL). The disease is managed using interventions such as
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In vivo imaging of synaptic density in neurodegenerative disorders with positron emission tomography: A systematic review Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-22 Malouke Visser, John T. O’Brien, Elijah Mak
Positron emission tomography (PET) with radiotracers that bind to synaptic vesicle glycoprotein 2 A (SV2A) enables quantification of synaptic density in the living human brain. Assessing the regional distribution and severity of synaptic density loss will contribute to our understanding of the pathological processes that precede atrophy in neurodegeneration. In this systematic review, we provide a
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Comparative efficacy, tolerability and acceptability of donanemab, lecanemab, aducanumab and lithium on cognitive function in mild cognitive impairment and Alzheimer's disease: A systematic review and network meta-analysis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-20 Itsuki Terao, Wakako Kodama
The comparative clinical utility of the disease-modifying treatments for mild cognitive impairment and Alzheimer's disease that are approved or under review by the Food and Drug Administration (i.e., donanemab, lecanemab and aducanumab), and lithium, which is a potential disease-modifying agent for this condition, remains elusive. We aimed to compare the efficacy on cognitive decline, tolerability
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The interference between SARS-COV-2 and Alzheimer’s disease: Potential immunological and neurobiological crosstalk from a kinase perspective reveals a delayed pandemic Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-18 Heba M. Mansour
Coronavirus disease 2019 (COVID-19) has infected over 700 million people, with up to 30% developing neurological manifestations, including dementias. However, there is a lack of understanding of common molecular brain markers causing Alzheimer's disease (AD). COVID-19 has etiological cofactors with AD, making patients with AD a vulnerable population at high risk of experiencing more severe symptoms
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The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-17 Hayder M. Al-kuraishy, Sadiq M. Al-Hamash, Majid S. Jabir, Ali I. Al-Gareeb, Ali K. Albuhadily, Salim Albukhaty, Ghassan M. Sulaiman
Parkinson disease (PD) is a common brain neurodegenerative disease due to progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). Of note, the cardio-metabolic disorders such as hypertension are adversely affect PD neuropathology through exaggeration of renin-angiotensin system (RAS). The RAS affects the stability of dopaminergic neurons in the SNpc, and exaggeration
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Ferroptosis: Mechanisms and role in diabetes mellitus and its complications Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-17 Pan Liu, Zhengdong Zhang, Yichen Cai, Zhaoying Li, Qian Zhou, Qiu Chen
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Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-17 Junling Guo, Vasiliki Orgeta, Isadora Olivé, Erik Hoff, Jonathan Huntley, Miranda Olff, Sjacko Sobczak
This systematic review aimed at synthesizing current evidence on biomarkers associated with cognitive impairment (CI) in Post-Traumatic Stress Disorder (PTSD). A systematic literature search was conducted for studies assessing biomarkers associated with CI in PTSD. Of the 10,149 titles screened, 8 studies met our inclusion criteria. In a single longitudinal study, MRI volumes, Aβ and tau accumulation
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Recent trends in treatment strategies for Alzheimer's disease and the challenges: A topical advancement Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-15 Ni Liu, Xiaohan Liang, Yu Chen, Lihang Xie
Alzheimer's Disease (AD) is an irreversible and progressive neurological disease that has affected at least 50 million people around the globe. Considering the severity of the disease and the continuous increase in the number of patients, the development of new effective drugs or intervention strategies for AD has become urgent. AD is caused by a combination of genetic, environmental, and lifestyle
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Passive immunotherapy for Alzheimer's disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-14 Xiaoyi Guo, Li Yan, Denghong Zhang, Yingjun Zhao
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by cognitive impairment with few therapeutic options. Despite many failures in developing AD treatment during the past 20 years, significant advances have been achieved in passive immunotherapy of AD very recently. Here, we review characteristics, clinical trial data, and mechanisms of action for monoclonal antibodies
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Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-01-12 Yuan-Wei Zhang, Yan Wu, Xiang-Fei Liu, Xiao Chen, Jia-Can Su