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- Russ. J. Genet.
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-
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- J. Parasitol.
- J. Reprod. Immunol.
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- BBA Gene Regul. Mech.
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- Channels
- Clin. Biomech.
- Curr. Opin. Struc. Biol.
- Dokl. Biochem. Biophys.
- Electromagn. Biol. Med.
- Eur. Biophys. J.
- FEBS Lett.
- Food Biophys.
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- Int. J. Biometeorol.
- J. Biol. Phys.
- J. Biomech.
- Nat. Struct. Mol. Biol.
- Photochem. Photobiol.
- Phys. Biol.
- Phys. Rev. E
- Pteridines
- Q. Rev. Biophys.
- Radiat. Res.
- Structure
-
神经科学
- All
- ACS Chem. Neurosci.
- Acta Neuropathol. Commun.
- Addict. Behav.
- Aging Neuropsychol. Cognit.
- Alzheimer Dis. Assoc. Disord.
- Am. J. Alzheimers Dis. Other Demen.
- Amyotroph. Lateral Scler. Frontotemporal Degener.
- Ann. Anat.
- Ann. Indian Acad. Neurol.
- Annu. Rev. Neurosci.
- Annu. Rev. Vis. Sci.
- Aphasiology
- Arch. Ital. Biol.
- Arts Psychother.
- ASN Neuro
- Auton. Neurosci.
- BBA Gen. Subj.
- Behav. Brain Funct.
- Behav. Brain Res.
- Behav. Brain. Sci.
- Behav. Neurol.
- Behav. Neurosci.
- Biol. Cybern.
- Biol. Psychiatry
- bioRxiv. Neurosci.
- Bipolar Disord.
- BMC Neurosci.
- BMJ Neurol. Open
- Brain
- Brain Behav. Evol.
- Brain Behav. Immun.
- Brain Cognit.
- Brain Connect.
- Brain Dev.
- Brain Imaging Behav.
- Brain Inj.
- Brain Pathol.
- Brain Res.
- Brain Res. Bull.
- Brain Sci.
- Brain Stimul.
- Cell. Mol. Neurobiol.
- Cephalalgia
- Cereb. Cortex
- Chem. Percept.
- Chem. Senses
- Childs Nerv. Syst.
- Clin. EEG Neurosci.
- Clin. Neurol. Neurosurg.
- Clin. Neurophysiol.
- Clin. Neuroradiol.
- CNS Drugs
- CNS Spectr.
- Cogn. Affect. Behav. Neurosci.
- Cogn. Dev.
- Cogn. Neurodyn.
- Cogn. Neuropsychol.
- Cogn. Syst. Res.
- Cognition
- Comput. Intell. Neurosci.
- Cortex
- Curr. Alzheimer Res.
- Curr. Opin. Behav. Sci.
- Curr. Opin. Neurobiol.
- Curr. Pain Headache Rep.
- Depression Anxiety
- Dev. Cogn. Neurosci.
- Dev. Neurobiol.
- Dev. Neuropsychol.
- Dev. Neurorehabil.
- Dev. Neurosci.
- Egypt. J. Neurol. Psychiatry Neurosurg.
- Egypt. J. Neurosurg.
- Epilepsia
- Epilepsy Behav.
- Eur. J. Nerosci.
- Eur. J. Neurol.
- Eur. J. Neurosci.
- Eur. J. Paediatr. Neurol.
- Eur. Neurol.
- Exp. Brain Res.
- Exp. Neurobiol.
- Fluids Barriers CNS
- Folia Neuropathol.
- Front Hum Neurosci
- Front. Cell. Neurosci.
- Front. Comput. Neurosci.
- Front. Integr. Neurosci.
- Front. Mol. Neurosci.
- Front. Neural Circuits
- Front. Neuroanat.
- Front. Neuroinform.
- Front. Neurol.
- Front. Neurorobotics
- Front. Neurosci.
- Front. Syst. Neurosci.
- Gait Posture
- Genes Brain Behav.
- Geroscience
- Glia
- Hum. Brain Mapp.
- Int. J. Dev. Neurosci.
- Int. J. Neural Syst.
- Int. J. Neuropsychopharmacol.
- Int. J. Neurosci.
- Int. Neurourol. J.
- Invertebr. Neurosci.
- J. Alzheimer’s Dis.
- J. Atten. Disord.
- J. Behav. Decis. Mak.
- J. Cogn. Neurosci.
- J. Cognit. Dev.
- J. Comput. Neurosci.
- J. Dual Diagn.
- J. Geriatr. Psychiatry Neurol.
- J. Math. Neurosc.
- J. Mem. Lang.
- J. Mot. Behav.
- J. Neural Eng.
- J. Neural. Transm.
- J. Neurochem.
- J. Neurogenet.
- J. Neuroimmune Pharmacol.
- J. Neuroimmunol.
- J. Neurol.
- J. Neurol. Sci.
- J. Neurolinguistics
- J. Neurophysiol.
- J. Neuroradiol.
- J. Neurosci.
- J. Neurosci. Methods
- J. Neurosci. Res.
- J. Neurotrauma
- J. Neurovirol.
- J. Parkinson’s Dis.
- J. Peripher. Nerv. Syst.
- J. Pineal. Res.
- J. Spinal Cord Med.
- J. Stroke Cerebrovasc. Dis.
- Laterality
- medRxiv. Neurol.
- Metab. Brain Dis.
- Mol. Brain
- Mol. Cell. Neurosci.
- Mol. Neurobiol.
- Muscle Nerve
- Nat. Neurosci.
- Nat. Rev. Neurosci.
- Neural Comput.
- Neural Netw.
- Neural Plast.
- Neural. Dev.
- Neuro Oncol.
- Neurobiol. Aging
- Neurobiol. Learn. Mem.
- Neurobiol. Stress
- Neurochem. Int.
- Neurochem. J.
- Neurodegener. Dis.
- Neuroendocrinology
- Neurogastroenterol. Motil.
- Neurogenetics
- NeuroImage
- Neuroimage Clin.
- Neuroinformatics
- Neurol. Res.
- Neurol. Sci.
- Neuromol. Med.
- Neuromuscul. Disord.
- Neuron
- Neuropathol. Appl. Neurobiol.
- Neuropeptides
- Neurophotonics
- Neurophysiology
- Neuropsychol. Rehabilit.
- Neurorehabilit. Neural Repair
- Neurosci Biobehav Rev
- Neurosci. Bull.
- Neurosci. Lett.
- Neurosci. Res.
- Neuroscience
- Neurosurg. Rev.
- Neurosurgery
- Neurotherapeutics
- Neurotoxicol. Teratol.
- Neurotoxicology
- npj Sci. Learn.
- Pain Pract.
- Pain Res. Manag.
- Parkinson's Dis.
- Pediatr. Neurol.
- Pract. Neurol.
- Prog. Neurobiol.
- Respir. Physiol. Neurobiol.
- Rev. Neurosci.
- Schmerz
- Sleep
- Sleep Biol. Rhythm.
- Soc. Cogn. Affect. Neurosci.
- Soc. Neurosci.
- Somatosens. Mot. Res.
- Synapse
- Trans. Neurosci.
- Trends Neurosci.
-
微生物
- All
- Acta Microbiol. Immunol. Hung.
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- Acta Trop.
- Adv. Appl. Microbiol.
- Aerobiologia
- AIDS Behav.
- Am. J. Enology Vitic.
- Anaerobe
- Anim. Biotechnol.
- Ann. Clin. Microbiol. Antimicrob.
- Ann. Microbiol.
- Annu. Rev. Microbiol.
- Antibiotics
- Antimicrob. Resist. Infect. Control
- Antivir. Ther.
- Antonie van Leeuwenhoek
- APMIS
- Appl. Biochem. Microbiol.
- Appl. Environ. Microb.
- Appl. Microbiol. Biotechnol.
- Aquat. Microb. Ecol.
- Arch. Immunol. Ther. Exp.
- Arch. Microbiol.
- Arch. Virol.
- Archaea
- Biodegradation
- Biofouling
- Biologicals
- BioMed Res. Int.
- bioRxiv. Microbiol.
- Biotechnol. Prog.
- BMC Microbiol.
- Braz. J. Microbiol.
- Can. J. Infect. Dis. Med. Microbiol.
- Cell Host Microbe
- Cell. Microbiol.
- Circ. J.
- Clin. Microbiol. Rev.
- Comp. Immunol. Microbiol. Infect. Dis.
- Crit. Rev. Eukaryot. Gene Expr.
- Crit. Rev. Microbiol.
- Curr. Microbiol.
- Curr. Opin. Microbiol.
- Cytotechnology
- Diagn. Microbiol. Infect. Dis.
- Dis. Markers
- Emerg. Microbes Infect.
- Enferm. Infecc. Microbiol. Clin.
- Environ. Microbiol.
- Environ. MicroBiol. Rep
- Enzyme Microb. Technol.
- Eur. J. Clin. Microbiol. Infect. Dis.
- Eur. J. Protistol.
- Expert Opin. Biol. Ther.
- Expert Rev. Anti Infect. Ther.
- Extremophiles
- FEMS Microbiol. Ecol.
- FEMS Microbiol. Lett.
- FEMS Microbiol. Rev.
- FEMS Yeast Res.
- Folia Microbiol.
- Food Environ. Virol.
- Food Microbiol.
- Food Technol. Biotechnol.
- Front. Cell. Infect. Microbiol.
- Front. Microbiol.
- Fungal Biol.
- Fungal Biol. Rev.
- Fungal Divers.
- Fungal Genet. Biol.
- Genes Genom.
- Geobiology
- Geomicrobiol. J.
- Gut Pathog.
- Harmful Algae
- Hereditas
- IMA Fungus
- Indian J. Med. Microbiol.
- Indian J. Microbiol.
- Int. Dairy J.
- Int. J. Biol. Markers
- Int. J. Food Microbiol.
- Int. J. Genom.
- Int. J. Med. Microbiol.
- Int. Microbiol.
- Intervirology
- J. Antimicrob. Chemother.
- J. Appl. Microbiol.
- J. Bacteriol.
- J. Basic Microbiol.
- J. Biosci. Bioeng.
- J. Chem. Technol. Biotechnol.
- J. Clin. Microbiol.
- J. Eukaryot. Microbiol.
- J. Gen. Virol.
- J. Ind. Microbiol. Biotechnol.
- J. Infect. Dis.
- J. Med. Microbiol.
- J. Microbiol.
- J. Microbiol. Biotechnol.
- J. Microbiol. Immunol. Infect.
- J. Microbiol. Methods
- J. Mol. Microbiol. Biotechnol.
- J. Oral Microbiol.
- J. Parasitol.
- J. Virol. Methods
- J. Water Health
- Lab Anim.
- Lett. Appl. Microbiol.
- Mar. Micropaleontol.
- mBio
- Med. Microbiol. Immunol.
- Med. Mycol.
- Mem. Inst. Oswaldo Cruz
- Microb. Drug Resist.
- Microb. Ecol.
- Microb. Genom.
- Microb. Pathog.
- Microb. Risk Anal.
- Microbes Environ.
- Microbes Infect.
- Microbiol. Immunol.
- Microbiol. Mol. Biol. Rev.
- Microbiol. Res.
- Microbiology
- Microbiome
- Microorganisms
- Mol. Microbiol.
- Mol. Oral Microbiol.
- Mol. Plant Microbe Interact.
- Molecul. Genet. Microbiol. Virol.
- mSphere
- mSystems
- Mult. Scler. J.
- Mycobiology
- MycoKeys
- Mycologia
- Mycopathologia
- Mycoscience
- Mycoses
- Mycotoxin. Res.
- Nat. Microbiol.
- Nat. Prod. Bioprospect.
- Nat. Rev. Microbiol.
- npj Biofilms Microbiomes
- Parasite Immunol.
- Plasmid
- Probiotics Antimicrob. Proteins
- Protist
- Res. Microbiol.
- Retrovirology
- Rev. Iberoam. Micol.
- Revis. Argent. Microbiol.
- Saudi J. Biol. Sci.
- South. Afr. J. Hiv Med.
- Stand. Genomic. Sci.
- Stud. Mycol.
- Syst. Appl. Microbiol.
- Trends Microbiol.
- Tuberculosis
- Vet. Microbiol.
- Virol. J.
- Virulence
- Virus Evol.
- Virus Genes
- Virus Res.
- Viruses
- World J. Microbiol. Biotechnol.
- Yeast
-
植物
- All
- Acta Physiol. Plant.
- Alp. Botany
- Am. J. Bot.
- Ann. Appl. Biol.
- Ann. Bot.
- Annu. Rev. Phytopathol.
- Annu. Rev. Plant Biol.
- AoB Plants
- Appl. Plant Sci.
- Aquat. Bot.
- Aust. J. Bot.
- Australasian Plant Pathol.
- bioRxiv. Plant Biol.
- BMC Plant Biol.
- Bot. J. Linn. Soc.
- Bot. Lett.
- Bot. Rev.
- Bot. Stud.
- Botanica Mar.
- Botany
- Braz. J. Bot.
- Brittonia
- Bull. Entomol. Res.
- Can. J. Plant Pathol.
- Clin. Phytosci.
- Commun. Soil Sci. Plant Anal.
- Crit. Rev. Plant Sci.
- Curr. Genomics
- Curr. Opin. Plant Biol.
- Dendrochronologia
- Econ. Bot.
- Environ. Exp. Bot.
- Euphytica
- Eur. J. Phycol.
- Eur. J. Plant Pathol.
- Flora
- Folia Geobot.
- Front. Plant Sci.
- Funct. Plant Biol.
- Grana
- Horticult. Plant J.
- In Vitro Cell. Dev. Biol.-Plant
- Indian J. Tradit. Knowl.
- Int. J. Fruit Sci.
- Int. J. Plant Prod.
- Int. J. Plant Sci.
- Invasive Plant Sci. Manag.
- J. Appl. Phycol.
- J. Appl. Res. Med. Plants
- J. Berry Res.
- J. Bryol.
- J. Essent. Oil Bear. Plants
- J. Ethnobiol. Ethnomed.
- J. Exp. Bot.
- J. Gen. Plant Pathol.
- J. Integr. Plant Biol.
- J. Nat. Med.
- J. Phycol.
- J. Phytopathol.
- J. Plant Biochem. Biot.
- J. Plant Biol.
- J. Plant Dis. Prot.
- J. Plant Ecol.
- J. Plant Growth. Regul.
- J. Plant Interact.
- J. Plant Nutr.
- J. Plant Pathol.
- J. Plant Physiol.
- J. Plant Regist.
- J. Plant Res.
- Kew Bull.
- Lichenologist
- Mol. Breed.
- Mol. Plant
- Mol. Plant Microbe Interact.
- Mol. Plant Pathol.
- Mycorrhiza
- N. Z. J. Bot.
- Nat. Plants
- New Phytol.
- Nord. J. Bot.
- Perspect. Plant Ecol. Evol. Syst.
- Photosynth. Res.
- Phycol. Res.
- Physiol. Mol. Biol. Plants
- Physiol. Mol. Plant Pathol.
- Physiol. Plant
- Phytochem. Anal.
- Phytochem. Lett.
- Phytochemistry
- PhytoKeys
- Phytoparasitica
- Phytopathology
- Plant Biol.
- Plant Biosyst.
- Plant Biotech. J.
- Plant Biotechnol. Rep.
- Plant Cell
- Plant Cell Environ.
- Plant Cell Physiol.
- Plant Cell Rep.
- Plant Cell Tiss. Organ Cult.
- Plant Commun.
- Plant Direct
- Plant Dis.
- Plant Ecol.
- Plant Ecol. Divers.
- Plant Genet. Resour.
- Plant Genome
- Plant Growth Regul.
- Plant J.
- Plant Methods
- Plant Mol. Biol.
- Plant Mol. Biol. Rep.
- Plant Pathol.
- Plant Pathol. J.
- Plant Physiol.
- Plant Physiol. Biochem.
- Plant Reprod.
- Plant Sci.
- Plant Signal Behav.
- Plant Soil
- Plant Species Biol.
- Plant Syst. Evol.
- Planta
- Plants
- Rev. Palaeobot. Palynol.
- Rhizosphere
- Russ. J. Plant Physiol.
- S. Afr. J. Bot.
- Theor. Exp. Plant Physiol.
- Tree Genet. Genomes
- Trees
- Trends Plant Sci.
- Trop. Plant Pathol.
- Tropical Plant Biol.
- Weed Technol.
-
生工
- All
- ACS Biomater. Sci. Eng.
- Algal. Res.
- AMB Express
- Anim. Biotechnol.
- Ann. Biomed. Eng.
- Annu. Rev. Biomed. Eng.
- Appl. Microbiol. Biotechnol.
- Artif. Cells Nanomed. Biotechnol.
- Bio-des. Manuf.
- Bio-Medical Mater. Eng.
- Biochem. Eng. J.
- Bioeng. Transl. Med.
- Bioengineered
- Biofabrication
- Bioinspired, Biomimetic Nanobiomater.
- Biol. Control
- Biol. Trace Elem. Res.
- Biomarkers
- Biomed. Eng. Biomed. Tech.
- BioMed. Eng. OnLine
- Bioprocess Biosyst. Eng.
- Bioresour. Bioprocess.
- Biorheology
- bioRxiv. Bioeng.
- Biotech. Histochem.
- Biotechniques
- Biotechnol. Adv.
- Biotechnol. Appl. Bioc.
- Biotechnol. Bioeng.
- Biotechnol. Genet. Eng. Rev.
- Biotechnol. J.
- Biotechnol. Prog.
- BMC Biomed. Eng.
- BMC Biotechnol.
- Cardiovasc. Eng. Technol.
- Cel. Mol. Bioeng.
- CRISPR J.
- Crit. Rev. Biotechnol.
- Crit. Rev. Eukaryot. Gene Expr.
- Curr. Opin. Biotech.
- Cytotechnology
- Digit Biomark.
- Ecol. Eng.
- Eng. Life Sci.
- Food Biosci.
- Hum. Gene Ther.
- IEEE Pulse
- IEEE Trans. Biomed. Circuits Syst.
- IEEE Trans. Biomed. Eng.
- IEEE Trans. Med. Imaging
- IEEE Trans. NanoBiosci.
- IEEE Trans. Netural Syst. Rehabil. Eng.
- Int. Dairy J.
- Int. Endod. J
- Int. J. Biol. Markers
- Int. J. Numer. Method. Biomed. Eng.
- Int. Microbiol.
- J. Am. Soc. Brew. Chem.
- J. Appl. Microbiol.
- J. Biol. Eng.
- J. Biomech.
- J. Biosci. Bioeng.
- J. Biotechnol.
- J. Food Process Eng.
- J. Genet. Eng. Biotechnol.
- J. Ind. Microbiol. Biotechnol.
- J. Microbiol. Biotechnol.
- J. Microelectromech. Syst.
- J. Mol. Cell. Cardiol.
- J. Mol. Microbiol. Biotechnol.
- J. Nanobiotechnol.
- J. Tissue Eng.
- Med. Biol. Eng. Comput.
- Med. Eng. Phys.
- Metab. Eng.
- Microb. Biotechnol.
- Microb. Cell Fact.
- Mol. Biotechnol.
- Nat. Biomed. Eng.
- Nat. Biotechnol.
- Nat. Prod. Bioprospect.
- Nucleic Acid Ther.
- Pacing Clin. Electrophysiol.
- Plant Biotechnol. Rep.
- Proc. Inst. Mech. Eng. Part H J. Mech. Eng. Med.
- Protein Eng. Des. Sel.
- Regen. Ther.
- Rejuvenation Res.
- Stem Cells Int.
- Tissue Eng. Part A
- Tissue Eng. Part B Rev.
- Tissue Eng. Part C Method
- Trends Biotechnol.
-
生态
- All
- Acta Oecol.
- Afr. J. Ecol.
- African J. Range Forage Sci.
- Alcheringa
- Ann. Appl. Biol.
- Ann. Microbiol.
- Annu. Rev. Ecol. Evol. Syst.
- Annu. Rev. Physiol.
- Aquat. Microb. Ecol.
- Austral Ecol.
- Basic Appl. Ecol.
- Behav. Ecol. Sociobiol.
- Biochem. Syst. Ecol.
- Biodegradation
- Biodivers. Data J.
- Biol. Invasions
- bioRxiv. Ecol.
- Biotropica
- BMC Ecol.
- Bot. J. Linn. Soc.
- Catena
- Chem. Ecol.
- Community Ecol.
- Conserv. Biol.
- Conserv. Lett.
- Contemp. Probl. Ecol.
- Ecohealth
- Ecol. Appl.
- Ecol. Complex.
- Ecol. Econ.
- Ecol. Eng.
- Ecol. Entomol.
- Ecol. Evol.
- Ecol. Indic.
- Ecol. Lett.
- Ecol. Manag. Restor.
- Ecol. Monogr.
- Ecology
- Ecosyst. Serv.
- Ecotoxicology.
- Environ. Biol. Fish.
- Environmetrics
- Eur. J. Wildl. Res.
- Explor. Geophys.
- FEMS Microbiol. Ecol.
- Flora
- Freshw. Sci.
- Freshwater Biol.
- Front. Ecol. Environ.
- Front. Ecol. Evolut.
- Funct. Ecol.
- Fungal Ecol.
- Geobiology
- Glob. Ecol. Biogeogr.
- Glob. Ecol. Conserv.
- Grana
- Hum. Ecol. Risk Assess.
- Hydrobiologia
- Ichnos
- Insectes Soc.
- ISME J.
- J. Anim. Ecol.
- J. Chem. Ecol.
- J. Ecol.
- J. Ethnobiol. Ethnomed.
- J. Evol. Biol.
- J. Exp. Mar. Biol. Ecol.
- J. Freshw. Ecol.
- J. Insect Behav.
- J. Nat. Hist.
- J. Plant Ecol.
- J. Trop. Ecol.
- J. Vector Ecol.
- Journal of Vegetation Science
- Mammal Rev.
- Mar. Biodivers.
- Mar. Ecol.
- Methods Ecol. Evol.
- Mol. Ecol.
- Mol. Ecol. Resour.
- Mov. Ecol.
- Mycorrhiza
- Nat. Conserv.
- Nat. Ecol. Evol.
- NeoBiota
- Oecologia
- Oryx
- Palaeobio. Palaeoenv.
- Palaeogeogr. Palaeoclimatol. Palaeoecol.
- Pedobiologia
- Perspect. Ecol. Conserv.
- Perspect. Plant Ecol. Evol. Syst.
- Phycol. Res.
- Plant Soil
- Polar Res.
- Polar Sci.
- Proc. Acad. Nat. Sci. Philadelphia
- Rangel. J.
- Rev. Chilena Hist. Nat.
- Russ. J. Ecol.
- Soil Biol. Biochem.
- Theor. Ecol.
- Trends Ecol. Evol.
- Trop. Anim. Health Prod.
- Trop. Ecol.
- Urban Ecosyst.
- Virus Evol.
- Wetlands
-
其他
- All
- Acta Agric. Scand. Sect. A Anim. Sci.
- Acta Physiol.
- Acta. Ethol.
- Adv. Theory Simul.
- Afr. J. Herpetol.
- Ageing Res. Rev.
- Alcohol
- Alcohol Alcohol.
- Altern. Lab. Anim.
- Am. J. Bioethics
- Am. J. Physiol. Regul. Integr. Comp. Physiol.
- Am. J. Physiol. Renal Physiol.
- Am. J. Primatol.
- Am. Nat.
- Anim. Behav.
- Anim. Cogn.
- Anim. Conserv.
- Anim. Feed Sci. Technol.
- Anim. Health Res. Rev.
- Anim. Prod. Sci.
- Anim. Reprod. Sci.
- Anim. Sci. J.
- Animal
- Ann. Behav. Med.
- Ann. Hum. Biol.
- Ann. Paleontol.
- Annu. Rev. Anim. Biosci.
- Annu. Rev. Entomol.
- Annu. Rev. Physiol.
- Apidologie
- Appl. Anim. Behav. Sci.
- Appl. Bionics Biomech.
- Appl. Entomol. Zool.
- Appl. Physiol. Nutr. Metab.
- Appl. Psychophysiol. Biofeedback
- Appl. Sci.
- Aquat. Biol.
- Aquat. Ecosyst. Health Manag.
- Aquat. Insects
- Arch. Anim. Nutr.
- Arch. Toxicol.
- Archaeol. Anthropol. Sci.
- Archaeometry
- Arthropod Struct. Dev.
- Asian Australas. J. Anim. Sci.
- Astrobiology
- Avian Biol. Res.
- Avian Res.
- BBA Bioenerg.
- BBA Biomembr.
- Behav. Processes
- Bioacoustics
- Biocatal. Biotransform.
- Biochem. Mol. Biol. Educ.
- Biocontrol Sci. Technol.
- Biocybern. Biomed. Eng.
- Biodivers. Conserv.
- Bioelectromagnetics
- Bioenerg. Res.
- Bioinformatics
- Bioinspir. Biomim.
- Biol. Conserv.
- Biol. J. Linn. Soc.
- Biol. Philos.
- Biol. Reprod.
- Biol. Rhythm Res.
- Biom. J.
- Biomark. Res.
- Biomed. Res.
- Biometrics
- Biomicrofluidics
- Biopreserv. Biobank.
- bioRxiv. Anim. Behav. Cognit.
- bioRxiv. Bioinform.
- bioRxiv. Cancer Biol.
- bioRxiv. Dev. Biol.
- bioRxiv. Evol. Biol.
- bioRxiv. Mol. Biol.
- bioRxiv. Paleontol.
- bioRxiv. Pathol.
- bioRxiv. Pharmacol. Toxicol.
- bioRxiv. Physiol.
- bioRxiv. Sci. Commun. Educ.
- bioRxiv. Syst. Biol.
- bioRxiv. Zool.
- Biosens. Bioelectron. X
- Biostatistics
- Biotechnol. Law Rep.
- Bird Study
- Birth Defects Res.
- BMC Bioinform.
- BMC Dev. Biol.
- BMC Evol. Biol.
- BMC Zool.
- Br. J. Philos. Sci.
- Briti. J. Nutr.
- Bull. Math. Biol.
- Cancer Biol. Ther.
- Caribb. J. Sci.
- Cartilage
- Chelonian Conserv. Biol.
- Chem. Res. Toxicol.
- Chromatographia
- Chronobiol. Int.
- Comput. Biol. Med.
- Comput. Math. Method Med.
- Comput. Method Biomech. Biomed. Eng.
- Comput. Methods Programs Biomed.
- Conserv. Genet.
- Coral Reefs
- Cretac. Res.
- Cryobiology
- Curr. Opin. Insect Sci.
- Curr. Zool.
- Cytokine Growth Factor Rev.
- Database J. Biol. Databases Curation
- Dev. Dyn.
- Dev. Growth Differ.
- Development
- Diatom Res.
- Dis. Aquat. Org.
- Dis. Model Mech.
- Divers. Distrib.
- Diversity
- Domest. Anim. Endocrinol.
- Dose-Response
- Ecohydrol. Hydrobiol.
- Econ. Hum. Biol.
- Electron. J. Biotechnol.
- Emu Austral Ornithol.
- Endanger. Species Res.
- Entmol. Rev.
- Entomol. Gen.
- Entomol. Res.
- Entomol. Sci.
- Environ. Entomol.
- Environ. Exp. Bot.
- Environ. Mol. Mutagen.
- Ergonomics
- Ethology
- Eur. J. Mass Spectrom.
- Evol. Appl.
- Evol. Bioinf.
- Evol. Biol.
- Evol. Hum. Behav.
- Evol. Med. Public Health
- Evolut. Lett.
- Evolution
- Fly
- Food Bioprod. Process.
- Food Sci. Biotechnol.
- Free Radic. Res.
- Free Radical Bio. Med.
- Front. Marine Sci.
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Integrative computational approach identifies drug targets in CD4 + T-cell-mediated immune disorders npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2021-01-22 Bhanwar Lal Puniya; Rada Amin; Bailee Lichter; Robert Moore; Alex Ciurej; Sydney J. Bennett; Ab Rauf Shah; Matteo Barberis; Tomáš Helikar
CD4+ T cells provide adaptive immunity against pathogens and abnormal cells, and they are also associated with various immune-related diseases. CD4+ T cells’ metabolism is dysregulated in these pathologies and represents an opportunity for drug discovery and development. Genome-scale metabolic modeling offers an opportunity to accelerate drug discovery by providing high-quality information about possible
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A dynamic multi-tissue model to study human metabolism npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2021-01-22 Patricia Martins Conde; Thomas Pfau; Maria Pires Pacheco; Thomas Sauter
Metabolic modeling enables the study of human metabolism in healthy and in diseased conditions, e.g., the prediction of new drug targets and biomarkers for metabolic diseases. To accurately describe blood and urine metabolite dynamics, the integration of multiple metabolically active tissues is necessary. We developed a dynamic multi-tissue model, which recapitulates key properties of human metabolism
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Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2021-01-21 Paola Paci; Giulia Fiscon; Federica Conte; Rui-Sheng Wang; Lorenzo Farina; Joseph Loscalzo
In this study, we integrate the outcomes of co-expression network analysis with the human interactome network to predict novel putative disease genes and modules. We first apply the SWItch Miner (SWIM) methodology, which predicts important (switch) genes within the co-expression network that regulate disease state transitions, then map them to the human protein–protein interaction network (PPI, or
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Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2021-01-08 Selva Rupa Christinal Immanuel; Avinash D. Ghanate; Dharmeshkumar S. Parmar; Ritu Yadav; Riya Uthup; Venkateswarlu Panchagnula; Anu Raghunathan
Metabolic reprogramming and its molecular underpinnings are critical to unravel the duality of cancer cell function and chemo-resistance. Here, we use a constraints-based integrated approach to delineate the interplay between metabolism and epigenetics, hardwired in the genome, to shape temozolomide (TMZ) resistance. Differential metabolism was identified in response to TMZ at varying concentrations
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Sparsely-connected autoencoder (SCA) for single cell RNAseq data mining npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2021-01-05 Luca Alessandri; Francesca Cordero; Marco Beccuti; Nicola Licheri; Maddalena Arigoni; Martina Olivero; Maria Flavia Di Renzo; Anna Sapino; Raffaele Calogero
Single-cell RNA sequencing (scRNAseq) is an essential tool to investigate cellular heterogeneity. Thus, it would be of great interest being able to disclose biological information belonging to cell subpopulations, which can be defined by clustering analysis of scRNAseq data. In this manuscript, we report a tool that we developed for the functional mining of single cell clusters based on Sparsely-Connected
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Assessment of skin barrier function using skin images with topological data analysis npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-12-18 Keita Koseki; Hiroshi Kawasaki; Toru Atsugi; Miki Nakanishi; Makoto Mizuno; Eiji Naru; Tamotsu Ebihara; Masayuki Amagai; Eiryo Kawakami
Recent developments of molecular biology have revealed diverse mechanisms of skin diseases, and precision medicine considering these mechanisms requires the frequent objective evaluation of skin phenotypes. Transepidermal water loss (TEWL) is commonly used for evaluating skin barrier function; however, direct measurement of TEWL is time-consuming and is not convenient for daily clinical practice. Here
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Environmental flexibility does not explain metabolic robustness npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-11-27 Julian Libiseller-Egger; Ben Coltman; Matthias P. Gerstl; Jürgen Zanghellini
Cells show remarkable resilience against genetic and environmental perturbations. However, its evolutionary origin remains obscure. In order to leverage methods of systems biology for examining cellular robustness, a computationally accessible way of quantification is needed. Here, we present an unbiased metric of structural robustness in genome-scale metabolic models based on concepts prevalent in
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Mitochondria interaction networks show altered topological patterns in Parkinson’s disease npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-11-10 Massimiliano Zanin; Bruno F. R. Santos; Paul M. A. Antony; Clara Berenguer-Escuder; Simone B. Larsen; Zoé Hanss; Peter A. Barbuti; Aidos S. Baumuratov; Dajana Grossmann; Christophe M. Capelle; Joseph Weber; Rudi Balling; Markus Ollert; Rejko Krüger; Nico J. Diederich; Feng Q. He
Mitochondrial dysfunction is linked to pathogenesis of Parkinson’s disease (PD). However, individual mitochondria-based analyses do not show a uniform feature in PD patients. Since mitochondria interact with each other, we hypothesize that PD-related features might exist in topological patterns of mitochondria interaction networks (MINs). Here we show that MINs formed nonclassical scale-free supernetworks
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Uncovering cancer gene regulation by accurate regulatory network inference from uninformative data npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-11-09 Deniz Seçilmiş; Thomas Hillerton; Daniel Morgan; Andreas Tjärnberg; Sven Nelander; Torbjörn E. M. Nordling; Erik L. L. Sonnhammer
The interactions among the components of a living cell that constitute the gene regulatory network (GRN) can be inferred from perturbation-based gene expression data. Such networks are useful for providing mechanistic insights of a biological system. In order to explore the feasibility and quality of GRN inference at a large scale, we used the L1000 data where ~1000 genes have been perturbed and their
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Learning to encode cellular responses to systematic perturbations with deep generative models npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-11-06 Yifan Xue; Michael Q. Ding; Xinghua Lu
Cellular signaling systems play a vital role in maintaining homeostasis when a cell is exposed to different perturbations. Components of the systems are organized as hierarchical networks, and perturbing different components often leads to transcriptomic profiles that exhibit compositional statistical patterns. Mining such patterns to investigate how cellular signals are encoded is an important problem
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Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-11-06 Blessy George; Annie Lumen; Christine Nguyen; Barbara Wesley; Jian Wang; Julie Beitz; Victor Crentsil
Pregnancy is a period of significant change that impacts physiological and metabolic status leading to alterations in the disposition of drugs. Uncertainty in drug dosing in pregnancy can lead to suboptimal therapy, which can contribute to disease exacerbation. A few studies show there are increased dosing requirements for antidepressants in late pregnancy; however, the quantitative data to guide dose
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ROS networks: designs, aging, Parkinson’s disease and precision therapies npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-10-26 Alexey N. Kolodkin; Raju Prasad Sharma; Anna Maria Colangelo; Andrew Ignatenko; Francesca Martorana; Danyel Jennen; Jacco J. Briedé; Nathan Brady; Matteo Barberis; Thierry D. G. A. Mondeel; Michele Papa; Vikas Kumar; Bernhard Peters; Alexander Skupin; Lilia Alberghina; Rudi Balling; Hans V. Westerhoff
How the network around ROS protects against oxidative stress and Parkinson’s disease (PD), and how processes at the minutes timescale cause disease and aging after decades, remains enigmatic. Challenging whether the ROS network is as complex as it seems, we built a fairly comprehensive version thereof which we disentangled into a hierarchy of only five simpler subnetworks each delivering one type of
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Model-driven design allows growth of Mycoplasma pneumoniae on serum-free media npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-10-23 Erika Gaspari; Antoni Malachowski; Luis Garcia-Morales; Raul Burgos; Luis Serrano; Vitor A. P. Martins dos Santos; Maria Suarez-Diez
Mycoplasma pneumoniae is a slow-growing, human pathogen that causes atypical pneumonia. Because it lacks a cell wall, many antibiotics are ineffective. Due to its reduced genome and dearth of many biosynthetic pathways, this fastidious bacterium depends on rich, undefined medium for growth, which makes large-scale cultivation challenging and expensive. To understand factors limiting growth, we developed
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3D convolutional neural networks-based segmentation to acquire quantitative criteria of the nucleus during mouse embryogenesis npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-10-20 Yuta Tokuoka; Takahiro G. Yamada; Daisuke Mashiko; Zenki Ikeda; Noriko F. Hiroi; Tetsuya J. Kobayashi; Kazuo Yamagata; Akira Funahashi
During embryogenesis, cells repeatedly divide and dynamically change their positions in three-dimensional (3D) space. A robust and accurate algorithm to acquire the 3D positions of the cells would help to reveal the mechanisms of embryogenesis. To acquire quantitative criteria of embryogenesis from time-series 3D microscopic images, image processing algorithms such as segmentation have been applied
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Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-10-20 Charles J. Norsigian; Heather A. Danhof; Colleen K. Brand; Numan Oezguen; Firas S. Midani; Bernhard O. Palsson; Tor C. Savidge; Robert A. Britton; Jennifer K. Spinler; Jonathan M. Monk
Hospital acquired Clostridioides (Clostridium) difficile infection is exacerbated by the continued evolution of C. difficile strains, a phenomenon studied by multiple laboratories using stock cultures specific to each laboratory. Intralaboratory evolution of strains contributes to interlaboratory variation in experimental results adding to the challenges of scientific rigor and reproducibility. To
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Author Correction: Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-09-14 Natalia Mastrogamvraki,Apostolos Zaravinos
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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A global network for network medicine. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-08-31 Bradley A Maron,Lucia Altucci,Jean-Luc Balligand,Jan Baumbach,Peter Ferdinandy,Sebastiano Filetti,Paolo Parini,Enrico Petrillo,Edwin K Silverman,Albert-László Barabási,Joseph Loscalzo,
Network Medicine is now an established scientific discipline, having generated key insights on integrated mechanisms underlying complex human diseases. The next discovery phase will emphasize innovating analytics that optimize networks for advancing precision medicine. Accomplishing this goal will require organizing a scientifically diverse team studying big datasets shared globally.
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Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-08-28 Iraj Hosseini,Kapil Gadkar,Eric Stefanich,Chi-Chung Li,Liping L Sun,Yu-Waye Chu,Saroja Ramanujan
Mosunetuzumab, a T-cell dependent bispecific antibody that binds CD3 and CD20 to drive T-cell mediated B-cell killing, is currently being tested in non-Hodgkin lymphoma. However, potent immune stimulation with T-cell directed therapies poses the risk of cytokine release syndrome, potentially limiting dose and utility. To understand mechanisms behind safety and efficacy and explore safety mitigation
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Inferring clonal composition from multiple tumor biopsies. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-08-25 Matteo Manica,Hyunjae Ryan Kim,Roland Mathis,Philippe Chouvarine,Dorothea Rutishauser,Laura De Vargas Roditi,Bence Szalai,Ulrich Wagner,Kathrin Oehl,Karim Saba,Arati Pati,Julio Saez-Rodriguez,Angshumoy Roy,Donald W Parsons,Peter J Wild,María Rodríguez Martínez,Pavel Sumazin
Knowledge about the clonal evolution of a tumor can help to interpret the function of its genetic alterations by identifying initiating events and events that contribute to the selective advantage of proliferative, metastatic, and drug-resistant subclones. Clonal evolution can be reconstructed from estimates of the relative abundance (frequency) of subclone-specific alterations in tumor biopsies, which
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Multiomics data integration unveils core transcriptional regulatory networks governing cell-type identity. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-08-24 Sascha Jung,Antonio Del Sol
A plethora of computational approaches have been proposed for reconstructing gene regulatory networks (GRNs) from gene expression data. However, gene regulatory processes are often too complex to predict from the transcriptome alone. Here, we present a computational method, Moni, that systematically integrates epigenetics, transcriptomics, and protein–protein interactions to reconstruct GRNs among
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Whole-genome sequencing and gene network modules predict gemcitabine/carboplatin-induced myelosuppression in non-small cell lung cancer patients. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-08-24 Niclas Björn,Tejaswi Venkata Satya Badam,Rapolas Spalinskas,Eva Brandén,Hirsh Koyi,Rolf Lewensohn,Luigi De Petris,Zelmina Lubovac-Pilav,Pelin Sahlén,Joakim Lundeberg,Mika Gustafsson,Henrik Gréen
Gemcitabine/carboplatin chemotherapy commonly induces myelosuppression, including neutropenia, leukopenia, and thrombocytopenia. Predicting patients at risk of these adverse drug reactions (ADRs) and adjusting treatments accordingly is a long-term goal of personalized medicine. This study used whole-genome sequencing (WGS) of blood samples from 96 gemcitabine/carboplatin-treated non-small cell lung
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Linking metabolic phenotypes to pathogenic traits among "Candidatus Liberibacter asiaticus" and its hosts. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-08-04 Cristal Zuñiga,Beth Peacock,Bo Liang,Greg McCollum,Sonia C Irigoyen,Diego Tec-Campos,Clarisse Marotz,Nien-Chen Weng,Alejandro Zepeda,Georgios Vidalakis,Kranthi K Mandadi,James Borneman,Karsten Zengler
Candidatus Liberibacter asiaticus (CLas) has been associated with Huanglongbing, a lethal vector-borne disease affecting citrus crops worldwide. While comparative genomics has provided preliminary insights into the metabolic capabilities of this uncultured microorganism, a comprehensive functional characterization is currently lacking. Here, we reconstructed and manually curated genome-scale metabolic
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Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-07-31 Natalia Mastrogamvraki,Apostolos Zaravinos
The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and spot the major hub proteins within these networks. We reanalyzed 19 GEO gene expression profiles to identify and annotate CRC versus normal signatures, single-gene perturbation,
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Temporal ordering of omics and multiomic events inferred from time-series data. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-07-16 Sandeep Kaur,Timothy J Peters,Pengyi Yang,Laurence Don Wai Luu,Jenny Vuong,James R Krycer,Seán I O'Donoghue
Temporal changes in omics events can now be routinely measured; however, current analysis methods are often inadequate, especially for multiomics experiments. We report a novel analysis method that can infer event ordering at better temporal resolution than the experiment, and integrates omic events into two concise visualizations (event maps and sparklines). Testing our method gave results well-correlated
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Supervised learning of gene-regulatory networks based on graph distance profiles of transcriptomics data. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-06-30 Zahra Razaghi-Moghadam,Zoran Nikoloski
Characterisation of gene-regulatory network (GRN) interactions provides a stepping stone to understanding how genes affect cellular phenotypes. Yet, despite advances in profiling technologies, GRN reconstruction from gene expression data remains a pressing problem in systems biology. Here, we devise a supervised learning approach, GRADIS, which utilises support vector machine to reconstruct GRNs based
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CODC: a Copula-based model to identify differential coexpression. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-06-19 Sumanta Ray,Snehalika Lall,Sanghamitra Bandyopadhyay
Differential coexpression has recently emerged as a new way to establish a fundamental difference in expression pattern among a group of genes between two populations. Earlier methods used some scoring techniques to detect changes in correlation patterns of a gene pair in two conditions. However, modeling differential coexpression by means of finding differences in the dependence structure of the gene
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Author Correction: Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology-based approach. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-06-12 Kishore Hari,Burhanuddin Sabuwala,Balaram Vishnu Subramani,Caterina A M La Porta,Stefano Zapperi,Francesc Font-Clos,Mohit Kumar Jolly
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Advice from a systems-biology model of the corona epidemics. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-06-12 Hans V Westerhoff,Alexey N Kolodkin
Using standard systems biology methodologies a 14-compartment dynamic model was developed for the Corona virus epidemic. The model predicts that: (i) it will be impossible to limit lockdown intensity such that sufficient herd immunity develops for this epidemic to die down, (ii) the death toll from the SARS-CoV-2 virus decreases very strongly with increasing intensity of the lockdown, but (iii) the
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A personalised approach for identifying disease-relevant pathways in heterogeneous diseases. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-06-09 Juhi Somani,Siddharth Ramchandran,Harri Lähdesmäki
Numerous time-course gene expression datasets have been generated for studying the biological dynamics that drive disease progression; and nearly as many methods have been proposed to analyse them. However, barely any method exists that can appropriately model time-course data while accounting for heterogeneity that entails many complex diseases. Most methods manage to fulfil either one of those qualities
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Stratification and prediction of drug synergy based on target functional similarity. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-06-02 Mi Yang,Patricia Jaaks,Jonathan Dry,Mathew Garnett,Michael P Menden,Julio Saez-Rodriguez
Drug combinations can expand therapeutic options and address cancer’s resistance. However, the combinatorial space is enormous precluding its systematic exploration. Therefore, synergy prediction strategies are essential. We here present an approach to prioritise drug combinations in high-throughput screens and to stratify synergistic responses. At the core of our approach is the observation that the
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Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology-based approach. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-05-18 Kishore Hari,Burhanuddin Sabuwala,Balaram Vishnu Subramani,Caterina A M La Porta,Stefano Zapperi,Francesc Font-Clos,Mohit Kumar Jolly
Metastasis is the cause of over 90% of cancer-related deaths. Cancer cells undergoing metastasis can switch dynamically between different phenotypes, enabling them to adapt to harsh challenges, such as overcoming anoikis and evading immune response. This ability, known as phenotypic plasticity, is crucial for the survival of cancer cells during metastasis, as well as acquiring therapy resistance. Various
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Dynamic resource allocation drives growth under nitrogen starvation in eukaryotes. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-05-15 Juan D Tibocha-Bonilla,Manish Kumar,Anne Richelle,Rubén D Godoy-Silva,Karsten Zengler,Cristal Zuñiga
Cells can sense changes in their extracellular environment and subsequently adapt their biomass composition. Nutrient abundance defines the capability of the cell to produce biomass components. Under nutrient-limited conditions, resource allocation dramatically shifts to carbon-rich molecules. Here, we used dynamic biomass composition data to predict changes in growth and reaction flux distributions
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Prostate cancer screening research can benefit from network medicine: an emerging awareness. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-05-07 Valeria Panebianco,Martina Pecoraro,Giulia Fiscon,Paola Paci,Lorenzo Farina,Carlo Catalano
Up to date, screening for prostate cancer (PCa) remains one of the most appealing but also a very controversial topics in the urological community. PCa is the second most common cancer in men worldwide and it is universally acknowledged as a complex disease, with a multi-factorial etiology. The pathway of PCa diagnosis has changed dramatically in the last few years, with the multiparametric magnetic
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Genomic competition for noise reduction shaped evolutionary landscape of mir-4673. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-05-06 Ramin M Farahani,Saba Rezaei-Lotfi,Neil Hunter
The genomic platform that informs evolution of microRNA cascades remains unknown. Here we capitalised on the recent evolutionary trajectory of hominin-specific miRNA-4673, encoded in intron 4 of notch-1, to uncover the identity of one such precursor genomic element and the selective forces acting upon it. The miRNA targets genes that regulate Wnt/β-catenin signalling cascade. Primary sequence of the
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Genetic interactions derived from high-throughput phenotyping of 6589 yeast cell cycle mutants. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-05-06 Jenna E Gallegos,Neil R Adames,Mark F Rogers,Pavel Kraikivski,Aubrey Ibele,Kevin Nurzynski-Loth,Eric Kudlow,T M Murali,John J Tyson,Jean Peccoud
Over the last 30 years, computational biologists have developed increasingly realistic mathematical models of the regulatory networks controlling the division of eukaryotic cells. These models capture data resulting from two complementary experimental approaches: low-throughput experiments aimed at extensively characterizing the functions of small numbers of genes, and large-scale genetic interaction
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The FLAME-accelerated signalling tool (FaST) for facile parallelisation of flexible agent-based models of cell signalling. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-04-20 Gavin Fullstone,Cristiano Guttà,Amatus Beyer,Markus Rehm
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Clb3-centered regulations are recurrent across distinct parameter regions in minimal autonomous cell cycle oscillator designs. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-04-03 Thierry D G A Mondeel,Oleksandr Ivanov,Hans V Westerhoff,Wolfram Liebermeister,Matteo Barberis
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Erratum: Publisher Correction: Genetic interaction networks mediate individual statin drug response in Saccharomyces cerevisiae. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-04-02 Bede P Busby,Eliatan Niktab,Christina A Roberts,Jeffrey P Sheridan,Namal V Coorey,Dinindu S Senanayake,Lisa M Connor,Andrew B Munkacsi,Paul H Atkinson
[This corrects the article DOI: 10.1038/s41540-019-0112-5.].
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A hybrid stochastic model of the budding yeast cell cycle. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-03-27 Mansooreh Ahmadian,John J Tyson,Jean Peccoud,Yang Cao
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Towards a widespread adoption of metabolic modeling tools in biopharmaceutical industry: a process systems biology engineering perspective. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-03-13 Anne Richelle,Blandine David,Didier Demaegd,Marianne Dewerchin,Romain Kinet,Angelo Morreale,Rui Portela,Quentin Zune,Moritz von Stosch
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Chromosomal origin of replication coordinates logically distinct types of bacterial genetic regulation. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-02-17 Kosmas Kosmidis,Kim Philipp Jablonski,Georgi Muskhelishvili,Marc-Thorsten Hütt
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An integrated computational and experimental study to investigate Staphylococcus aureus metabolism. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-01-30 Mohammad Mazharul Islam,Vinai C Thomas,Matthew Van Beek,Jong-Sam Ahn,Abdulelah A Alqarzaee,Chunyi Zhou,Paul D Fey,Kenneth W Bayles,Rajib Saha
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Author Correction: Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-01-30 Noushin Hadadi,Vikash Pandey,Anush Chiappino-Pepe,Marian Morales,Hector Gallart-Ayala,Florence Mehl,Julijana Ivanisevic,Vladimir Sentchilo,Jan R van der Meer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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A scalable method for parameter-free simulation and validation of mechanistic cellular signal transduction network models. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-01-10 Jesper Romers,Sebastian Thieme,Ulrike Münzner,Marcus Krantz
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Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2020-01-07 Noushin Hadadi,Vikash Pandey,Anush Chiappino-Pepe,Marian Morales,Hector Gallart-Ayala,Florence Mehl,Julijana Ivanisevic,Vladimir Sentchilo,Jan R van der Meer
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Multi-dimensional computational pipeline for large-scale deep screening of compound effect assessment: an in silico case study on ageing-related compounds. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2019-11-26 Vipul Gupta,Alina Crudu,Yukiko Matsuoka,Samik Ghosh,Roger Rozot,Xavier Marat,Sibylle Jäger,Hiroaki Kitano,Lionel Breton
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Mathematical model of hemodynamic mechanisms and consequences of glomerular hypertension in diabetic mice. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-12-10 Hari Shankar Mahato,Christine Ahlstrom,Rasmus Jansson-Löfmark,Ulrika Johansson,Gabriel Helmlinger,K Melissa Hallow
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Multi-experiment nonlinear mixed effect modeling of single-cell translation kinetics after transfection. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-12-10 Fabian Fröhlich,Anita Reiser,Laura Fink,Daniel Woschée,Thomas Ligon,Fabian Joachim Theis,Joachim Oskar Rädler,Jan Hasenauer
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Role of noise and parametric variation in the dynamics of gene regulatory circuits npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-11-05 Vivek Kohar, Mingyang Lu
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Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-11-05 Greta Del Mistro, Philippe Lucarelli, Ines Müller, Sébastien De Landtsheer, Anna Zinoveva, Meike Hutt, Martin Siegemund, Roland E. Kontermann, Stefan Beissert, Thomas Sauter, Dagmar Kulms
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Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-10-24 Anqi Jing, Frederick S. Vizeacoumar, Sreejit Parameswaran, Bjorn Haave, Chelsea E. Cunningham, Yuliang Wu, Roland Arnold, Keith Bonham, Andrew Freywald, Jie Han, Franco J. Vizeacoumar
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Context-dependent prediction of protein complexes by SiComPre npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-09-17 Simone Rizzetto, Petros Moyseos, Bianca Baldacci, Corrado Priami, Attila Csikász-Nagy
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The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-09-06 Jérémy Gruel, Julia Deichmann, Benoit Landrein, Thomas Hitchcock, Henrik Jönsson
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Prevalence and patterns of higher-order drug interactions in Escherichia coli npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-09-03 Elif Tekin, Cynthia White, Tina Manzhu Kang, Nina Singh, Mauricio Cruz-Loya, Robert Damoiseaux, Van M. Savage, Pamela J. Yeh
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Redefining environmental exposure for disease etiology npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-09-01 Stephen M. Rappaport
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Dynamic modeling of transcriptional gene regulatory network uncovers distinct pathways during the onset of Arabidopsis leaf senescence npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-08-31 Bharat Mishra, Yali Sun, TC Howton, Nilesh Kumar, M. Shahid Mukhtar
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A landscape view on the interplay between EMT and cancer metastasis npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2018-08-23 Chunhe Li, Gabor Balazsi
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A network-based approach to uncover microRNA-mediated disease comorbidities and potential pathobiological implications. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2019-11-13 Shuting Jin,Xiangxiang Zeng,Jiansong Fang,Jiawei Lin,Stephen Y Chan,Serpil C Erzurum,Feixiong Cheng
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From expression footprints to causal pathways: contextualizing large signaling networks with CARNIVAL. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2019-11-11 Anika Liu,Panuwat Trairatphisan,Enio Gjerga,Athanasios Didangelos,Jonathan Barratt,Julio Saez-Rodriguez
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A data driven approach reveals disease similarity on a molecular level. npj Syst. Biol. Appl. (IF 3.813) Pub Date : 2019-10-25 Kleanthi Lakiotaki,George Georgakopoulos,Elias Castanas,Oluf Dimitri Røe,Giorgos Borboudakis,Ioannis Tsamardinos