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Update on pituitary adenomas in the 2017 World Health Organization classification: innovations and perspectives Hormones (IF 1.962) Pub Date : 2021-01-16 George Kontogeorgos
The World Health Organization (WHO) classifications of tumors offer invaluable support in the diagnosis of tumors, with every new edition including novel information and diagnostic updates. The new 2017 WHO Classification of Tumors of Endocrine Organs, 4th edition, includes innovations in both terminology and diagnostic guidelines for pituitary adenomas, along with new entities, molecular information
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A critical review of the effects of vitamin K on glucose and lipid homeostasis: its potential role in the prevention and management of type 2 diabetes Hormones (IF 1.962) Pub Date : 2021-01-16 Nikolaos A. Varsamis, Georgios A. Christou, Dimitrios N. Kiortsis
In recent years, our knowledge regarding the physiological role of vitamin K has expanded beyond regulation of coagulation to include many other aspects of human health. In the present review, we aimed to evaluate the existing evidence for beneficial effects of vitamin K on type 2 diabetes and components of the metabolic syndrome as risk factors for cardiovascular disease. Increased dietary intake
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Effects of resistance training on muscle strength, insulin-like growth factor-1, and insulin-like growth factor–binding protein-3 in healthy elderly subjects: a systematic review and meta-analysis of randomized controlled trials Hormones (IF 1.962) Pub Date : 2021-01-13 Niloufar Amiri, Mehrdad Fathei, Mohammad Mosaferi Ziaaldini
Background Findings regarding the effects of resistance training (RT) on muscle strength, serum level of IGF-1, and its binding proteins are contradictory. To resolve this contradiction, we performed a systematic review and meta-analysis to investigate the effects of RT on muscle strength, the levels of serum IGF-1, and IGF-binding protein-3 in the elderly and aged. Materials and methods The PubMed
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Impact of fecal microbiota transplantation with capsules on the prevention of metabolic syndrome among patients with obesity Hormones (IF 1.962) Pub Date : 2021-01-09 Jessica R. Allegretti, Zain Kassam, Jonathan Hurtado, Julian R. Marchesi, Benjamin H. Mullish, Austin Chiang, Christopher C. Thompson, Bethany P. Cummings
Background Fecal microbiota transplantation (FMT) has been studied for the treatment of metabolic syndrome with varying success. However, the possibility of utilizing FMT to prevent metabolic syndrome is to date unknown. Methods Secondary analysis of a previously published double-blind, randomized, placebo-controlled pilot trial of FMT in obese metabolically healthy patients was conducted. Post-prandial
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Nomogram analysis of the influencing factors of diabetic foot in patients with diabetes mellitus Hormones (IF 1.962) Pub Date : 2021-01-07 Mingming Li, Tao Yuan, Supeng Li, Qizheng Sun
Purpose To explore the influencing factors of diabetic foot (DF) in diabetic patients and evaluate the influencing factors. Methods All 674 diabetic patients admitted to our hospital from January 2015 to June 2019 who met the research criteria were included as study subjects. Clinical data were collected retrospectively by filling in the case report form for clinical research, including the general
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Metabolic profile of patients with isolated systolic hypertension Hormones (IF 1.962) Pub Date : 2021-01-06 JA Papadakis, P Ioannou, V Theodorakopoulou, K Papanikolaou, G Vrentzos
Purpose/objective While hypertension is an important contributor to cardiovascular disease (CVD) and its treatment has well-established mortality benefits, there is uncertainty as regards the management of isolated systolic hypertension (ISH). Furthermore, the association of ISH with CVD and mortality has been established, but the metabolic characteristics of the affected population have not as yet
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Genetics of primary congenital hypothyroidism—a review Hormones (IF 1.962) Pub Date : 2021-01-05 Eirini Kostopoulou, Konstantinos Miliordos, Bessie Spiliotis
Purpose Congenital primary hypothyroidism (CH) is a state of inadequate thyroid hormone production detected at birth, caused either by absent, underdeveloped or ectopic thyroid gland (dysgenesis), or by defected thyroid hormone biosynthesis (dyshormonogenesis). A genetic component has been identified in many cases of CH. This review summarizes the clinical and biochemical features of the genetic causes
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Correction to: The role of the gut-brain axis in depression: endocrine, neural, and immune pathways Hormones (IF 1.962) Pub Date : 2020-12-11 Anastasios P. Makris, Minois Karianaki, Konstantinos I. Tsamis, Stavroula A. Paschou
A Correction to this paper has been published: https://doi.org/10.1007/s42000-020-00262-2
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Leonardo da Vinci: the Lady with an Ermine enigma Hormones (IF 1.962) Pub Date : 2020-11-23 Andrea Sisti, Payam Sadeghi
“Lady with an Ermine” (1489–1490) is an oil on walnut portrait by the Italian artist Leonardo da Vinci. The portrait’s subject is Cecilia Gallerani, the favorite mistress of Ludovico Sforza, known as “il Moro”, Duke of Milan. It was painted around the time of Cecilia’s pregnancy with Ludovico’s illegitimate son. Leonardo’s paintings are famous for hiding mysteries; thus, the truth about the “Lady with
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Distribution and effect of ghrelin genotype on plasma lipid and apolipoprotein profiles in obese and nonobese Chinese subjects Hormones (IF 1.962) Pub Date : 2020-11-12 Ruqiang Bai, Yu Liu, Chong Zhao, Jinhang Gao, Rui Liu
Purpose The hormone ghrelin has an important role in a wide range of metabolic and nonmetabolic processes. Ghrelin gene polymorphisms have been reported to influence obesity or lipid abnormalities in some ethnic groups. This study was conducted mainly to examine the possible association of ghrelin − 604 G > A and Leu72Met polymorphisms with obesity and related traits in a Southwest Chinese population
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Management of thyroid cancer: results from a German and French patient survey Hormones (IF 1.962) Pub Date : 2020-11-12 Matthias Büttner, Harald Rimmele, Beate Bartès, Susanne Singer, Markus Luster
Objective Various national and international guidelines for the management of thyroid cancer exist. The aim of this survey was to evaluate whether patients experience differences regarding the management of thyroid cancer in Germany and in France. Methods An online survey addressing diagnosis, treatment, aftercare, and information needs of thyroid cancer survivors was set up by the German and the French
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Hypergonadotrophic hypogonadism in a patient with transaldolase deficiency: novel mutation in the pentose phosphate pathway Hormones (IF 1.962) Pub Date : 2020-11-07 Naz Guleray Lafcı, Fatma Kurt Colak, Gulseren Sahin, Merve Sakar, Semra Çetinkaya, Senay Savas-Erdeve
Background Transaldolase (TALDO) deficiency (OMIM #606003) is a rare autosomal recessive multi-systemic disorder of carbohydrate metabolism. It has a vast phenotypic spectrum ranging from neonatal liver failure to slowly progressive liver cirrhosis and is characterized by intrauterine growth restriction, hepatosplenomegaly, bicytopenia, nephrolithiasis, and congenital heart disease. Methods and results
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LRBA deficiency: a rare cause of type 1 diabetes, colitis, and severe immunodeficiency Hormones (IF 1.962) Pub Date : 2020-11-05 Aslı Derya Kardelen, Manolya Kara, Dilek Güller, Esin Karakılıc Ozturan, Zehra Yavas Abalı, Serdar Ceylaner, Ayça Kıykım, Serdar Cantez, Selda Hancerlı Torun, Sukran Poyrazoglu, Firdevs Bas, Feyza Darendelıler
The biological role of the lipopolysaccharide-responsive beige-like anchor (LRBA) protein associated with the immune system is not to date well known. However, it is thought to regulate the CTLA4 protein, an inhibitory immunoreceptor. Chronic diarrhea, autoimmune disorders, organomegaly, frequent recurrent infections, hypogammaglobulinemia, chronic lung manifestations, and growth retardation are some
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Adequate vitamin D supplementation does not ameliorate bone loss following long limb-biliopancreatic diversion in morbidly obese women Hormones (IF 1.962) Pub Date : 2020-11-05 Sotirios Volonakis, Vasiliki Koika, George Tzavelas, Marina Skopeliti, George Skroubis, Fotis Kalfarentzos, Theodore Alexandrides
Objectives The objective of this study is to investigate the effect of adequate vitamin D supplementation on bone mineral density (BMD) following long limb-biliopancreatic diversion (LL-BPD), a malabsorptive bariatric operation. Background Marked weight loss following bariatric surgery is associated with significant decrease in BMD, attributed to the weight loss and to nutritional, mineral, and vitamin
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Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: systematic review and meta-analysis Hormones (IF 1.962) Pub Date : 2020-11-05 Mousa Khalafi, Karim Azali Alamdari, Michael E. Symonds, Hadi Nobari, Jorge Carlos-Vivas
Purpose/objective The aim of this study was to quantify circulating fibroblast growth factor 21 (FGF-21) changes during and immediately after acute exercise and, based on body weight, to identify the subgroups exhibiting the largest response. Methods The PubMed, Web of Science, and Cochrane Library electronic databases were searched up to December 2019 for studies published in English peer-reviewed
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Diabetic ketoacidosis in patients treated with SGLT2 inhibitors: experience at a tertiary hospital Hormones (IF 1.962) Pub Date : 2020-11-05 Labrini Papanastasiou, Spyridoula Glycofridi, Christos Gravvanis, Nikitas Skarakis, Irene Papadimitriou, Georgia Kanti, Chara Kapsali, Theodora Kounadi
Purpose Diabetic ketoacidosis (DKA) is a rare and life-threatening complication in patients with diabetes. Sodium–glucose co-transporter-2 inhibitors (SGLT2i) have rarely been associated with ketoacidosis. The aim of this retrospective study was to investigate DKA episodes occurring after SGLT2i treatment and to compare them to DKA episodes due to other causes. Methods The medical records of the years
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Colorectal cancer metastases to the thyroid gland—a systematic review Hormones (IF 1.962) Pub Date : 2020-11-04 Dimitrios K. Manatakis, Nikolaos Tasis, Maria Ioanna Antonopoulou, Athanasios Kordelas, Dimitrios Balalis, Dimitrios P. Korkolis, Sophia Tseleni-Balafouta
Background Despite its rich vasculature, the thyroid gland is a rare site of metastatic disease. We present a systematic review of colorectal cancer (CRC) thyroid metastases, with emphasis on diagnosis, therapeutic management, and oncological outcomes. Methods A systematic review of the English literature (1990 to 2019) was performed, using the PubMed, Embase, and Google Scholar bibliographic databases
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Endocrine consequences of treatment with the new androgen receptor axis-targeted agents for advanced prostate cancer Hormones (IF 1.962) Pub Date : 2020-11-02 Nikolaos Pyrgidis, Ioannis Vakalopoulos, Petros Sountoulides
Purpose Prostate cancer (PCa) is the commonest non-cutaneous malignancy worldwide and the second cause of cancer death among males in the USA. Approval of the new androgen receptor axis-targeted (ARAT) agents (abiraterone acetate, enzalutamide, apalutamide, and darolutamide) has altered the course of advanced PCa. We aimed to assess the endocrine and metabolic adverse events associated with treatment
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Effect of low-ratio n-6/n-3 PUFA on blood lipid level: a meta-analysis Hormones (IF 1.962) Pub Date : 2020-10-29 Na Li, Min Jia, Qianchun Deng, Zhen Wang, Fenghong Huang, Hanxue Hou, Tongcheng Xu
Purpose The aim of this meta-analysis was to evaluate the effects of low-ratio n-6/n-3 PUFA on blood lipid levels. Methods We searched the PubMed, Embase, and Cochrane Library databases for randomized controlled trials of n-6/n-3 PUFA interventions up to March 2019. The change values were calculated as weighted mean differences (WMDs) by using a random-effect model. Subgroup analysis and meta-regression
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Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients Hormones (IF 1.962) Pub Date : 2020-10-29 Leonidas Palaiodimos, Natalia Chamorro-Pareja, Dimitrios Karamanis, Weijia Li, Phaedon D. Zavras, Kai Ming Chang, Priyanka Mathias, Damianos G. Kokkinidis
Purpose Infectious diseases are more frequent and can be associated with worse outcomes in patients with diabetes. The aim of this study was to systematically review and conduct a meta-analysis of the available observational studies reporting the effect of diabetes on mortality among hospitalized patients with COVID-19. Methods The Medline, Embase, Google Scholar, and medRxiv databases were reviewed
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Adoption of and adherence to the Hellenic Diabetes Association guidelines for the management of subjects with type 2 diabetes mellitus by Greek physicians Hormones (IF 1.962) Pub Date : 2020-10-29 Nikolaos G. Bimpas, Vivian Auyeung, Anastasios Tentolouris, Evangelia Tzeravini, Ioanna Eleftheriadou, Nikolaos Tentolouris
Purpose The aim of this study was to evaluate the level of adoption of and adherence to the Hellenic Diabetes Association (HDA) guidelines for the management of individuals with type 2 diabetes mellitus (T2DM) by Greek physicians. Methods We used a constructed questionnaire distributed to physicians in Greece. The questionnaire assessed the adoption of and adherence to the general and treatment guidelines
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Effect of adjunctive hormonal therapy on testicular descent and spermatogenic function among children with cryptorchidism: a systematic review and meta-analysis Hormones (IF 1.962) Pub Date : 2020-10-29 Kaiping Zhang, Yin Zhang, Min Chao
Objectives To systematically evaluate the effect of adjunctive hormonal therapy on testicular descent and spermatogenic function among children with cryptorchidism. Methods A comprehensive literature search of electronic databases up to February 21, 2019 was performed. Continuous data of fertility indices were evaluated using weighted mean difference (WMD) with 95% confidence interval (CI), while nominal
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Cytochrome P450 oxidoreductase deficiency caused by a novel mutation in the POR gene in two siblings: case report and literature review Hormones (IF 1.962) Pub Date : 2020-10-29 Edip Unal, Meliha Demiral, Ruken Yıldırım, Funda Feryal Taş, Serdar Ceylaner, Mehmet Nuri Özbek
Introduction P450 oxidoreductase (POR) deficiency is a rare form of congenital adrenal hyperplasia. In both genders, it can lead to ambiguous genitalia, impaired steroidogenesis, and skeletal findings similar to those of Antley-Bixler syndrome. Cases We describe two cases of POR deficiency. The first case was an 8.5-year-old girl who was admitted to our clinic due to ambiguous genitalia. Karyotype
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Hormone therapy in female-to-male transgender patients: searching for a lifelong balance Hormones (IF 1.962) Pub Date : 2020-10-07 Luca Maria Schönauer, Miriam Dellino, Matteo Loverro, Carmine Carriero, Teresa Capursi, Claudia Leoni, Giuseppe Loverro, Edoardo Di Naro
Background Reassignment of a female-to-male (FtM) person requires gender-affirming, androgenic hormonal treatment that is planned to induce appropriate structural changes. This therapy must be prolonged long term, even after the sex reassignment surgery (SRS). The purpose of this study is to evaluate the effects of hormone therapy with testosterone in FtM subjects during a 24-month follow-up in order
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Oncologic manifestations of Klinefelter syndrome Hormones (IF 1.962) Pub Date : 2020-10-01 Alexsandra P. Rojas, Diana V. Vo, Lance Mwangi, Shabnam Rehman, Alan N. Peiris
Klinefelter syndrome (47,XXY) has a prevalence of approximately 1 in 500 males. It is a condition characterized by an extra X chromosome and is an underdiagnosed clinical entity. Inactivation of genes enables their escape from regulatory mechanisms, which can result in such classic physical manifestations as hypogonadism, gynecomastia, infertility, and various hormonal and physical abnormalities. While
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Thyroxine replacement modifies changes in deiodinase and thyroid hormone transporter expression induced by subclinical hypothyroidism in rats Hormones (IF 1.962) Pub Date : 2020-09-29 Kelen Carneiro Oliveira, Roberto Laureano-Melo, Rodrigo Rodrigues da Conceição, Janaina Sena de Souza, Wellington da Silva Cortês, Mônica Akemi Sato, Maria Izabel Chiamolera, Rui Monteiro Maciel, Gisele Giannocco
Purpose The potential benefits of treating subclinical hypothyroidism (SCH) are unclear and still controversial. Thus, we surgically induced SCH in rats and evaluated the effects of thyroxine (T4) replacement on the gene expression levels of deiodinases and thyroid hormone (TH) transporters in different tissues. Methods SCH was induced by hemithyroid electrocauterization. The control animals underwent
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The placebo phenomenon and the underlying mechanisms. Hormones (IF 1.962) Pub Date : 2020-09-17 P Theodosis-Nobelos,A Filotheidou,C Triantis
The clinical role of the placebo effect is a topic of increasing interest for the scientific community. Focus is shifting from the inert role of placebos in randomized controlled trials (RCTs) to potential effects in clinical applications, since the phenomenon is thought to be inherent in routine clinical practice, affecting therapy success rates. Mediation of the mind-brain-body relationship involves
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Leucippus, either male or death: a case of sex reversal by divine intervention. Hormones (IF 1.962) Pub Date : 2020-09-15 Georgios K Markantes,Konstantina Barouti,Maria I Stamou,Neoklis A Georgopoulos
The concept of metamorphosis (change of form, structure, or substance) is very frequently encountered in Ancient Greek and Roman literature. One of the most striking types of metamorphosis described in many myths is gender transformation, where a man becomes a woman or vice versa. Herein, we present a case of pubertal gender inversion, the marvelous story of the Cretan Leucippus, which not only inspired
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Effect of estradiol on enzymes of vascular extracellular nucleotide metabolism. Hormones (IF 1.962) Pub Date : 2020-09-15 Areta Hebanowska,Paulina Mierzejewska,Alicja Braczko
Purpose Estrogens have beneficial effects on the cardiovascular system, promoting vasodilation, endothelial cells growth, relaxation, and regulation of blood pressure. Some of these effects could be associated with the purinergic system known for the control of vasodilation, inflammation, and platelet function. The aim of our study was the evaluation of ATP, AMP, and adenosine extracellular catabolism
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A case series of bilateral inferior petrosal sinus sampling with desmopressin in evaluation of ACTH-dependent Cushing's syndrome in Iran. Hormones (IF 1.962) Pub Date : 2020-09-15 Fatemeh Rahmani,Maryam Mahdavi,Keyvan Edraki,Majid Valizadeh
Background Differentiating the etiology of ACTH-dependent Cushing’s syndrome (CS) has remained challenging due to the limited accuracy of noninvasive assays. Nowadays, bilateral inferior petrosal sinus sampling (BIPSS) with corticotropin-releasing hormone (CRH) is the gold standard method in the diagnostic work-up of complex CS. However, this method is as yet far from being widespread. The limited
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Diabetes distress is associated with individualized glycemic control in adults with type 2 diabetes mellitus Hormones (IF 1.962) Pub Date : 2020-08-25 Konstantina Th. Theodoropoulou, George D. Dimitriadis, Nikolaos Tentolouris, Christina Darviri, George P. Chrousos
Purpose It has been proposed that the negative emotional state of diabetes distress (DD) may exert a detrimental effect on glycemic outcomes of individuals struggling with diabetes-related challenges. Thus far, no study has investigated this association by utilizing individualized treatment targets of patients’ glycemic control. Therefore, we sought to identify the potential role of DD in the achievement
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Prevalence of nutritional deficiencies in bariatric surgery candidates and its effect on metabolic status Hormones (IF 1.962) Pub Date : 2020-08-18 Sílvia Cristina de Sousa Paredes, Fernando Mota-Garcia
Background Nutritional deficiencies are common among obese individuals and constitute one of the main concerns in the bariatric field. The aim of this study was to investigate nutritional status in bariatric surgery candidates, comparing individuals with and without metabolic syndrome (MetS) and to explore possible associations between nutritional and metabolic status. Methods Patients accepted for
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Behavioral assessment of females with congenital adrenal hyperplasia. Hormones (IF 1.962) Pub Date : 2020-08-01 Sherifa Ahmed Hamed,Fadia Ahmed Attiah,Refaat Fathy Abd Elaal,Mohamed Fawzy
Purpose Patients with congenital adrenal hyperplasia (CAH) have an increased risk of psychological/psychiatric symptoms and disorders. This study aimed to assess the behavior of girls with CAH and its independent risk variables. Methods This cross-sectional study included 55 girls with CAH due to 21-hydroxylase deficiency (mean age 12.64 ± 1.52 years; salt-wasting (SW) form = 20, simple virilizing
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Improvement of anti-Müllerian hormone and oxidative stress through regular exercise in Chinese women with polycystic ovary syndrome. Hormones (IF 1.962) Pub Date : 2020-07-28 Xia Wu,Heng Wu,Wenjiang Sun,Chen Wang
Purpose Structured exercise is shown to be one of the most effective lifestyle interventions for women with polycystic ovary syndrome (PCOS). Anti-Müllerian hormone (AMH) has been proposed as a marker of ovarian dysfunction, and oxidative stress plays an important role in the development of PCOS. We sought to investigate whether there was any effect of aerobic exercise on AMH levels and oxidative stress
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Triple A (Allgrove) syndrome due to AAAS gene mutation with a rare association of amyotrophy. Hormones (IF 1.962) Pub Date : 2020-07-22 Satyam Singh Jayant,Rahul Gupta,Kanhaiya Agrawal,Liza Das,Pinaki Dutta,Anil Bhansali
Introduction Triple A (Allgrove) syndrome is a rare autosomal recessive disorder characterized by cardinal features of primary adrenal insufficiency (AI) due to adrenocorticotropic hormone (ACTH) resistance, achalasia, and alacrima. It is frequently associated with neurological manifestations such as autonomic dysfunction, cognitive dysfunction, cranial nerve, or motor involvement. Amyotrophy/motor
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Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic. Hormones (IF 1.962) Pub Date : 2020-07-16 Rosaria Maddalena Ruggeri,Alfredo Campennì,Massimiliano Siracusa,Giuseppe Frazzetto,Damiano Gullo
Purpose Subacute thyroiditis (SAT) is an inflammatory thyroid disorder of viral origin, generally preceded by an upper respiratory tract infection. Since the disorder is self-limiting, it is frequently underdiagnosed. However, the disease should not be overlooked since the associated thyrotoxicosis may worsen the clinical course of concomitant disorders (e.g., respiratory distress) and long-term sequelae
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A systematic review and meta-analysis of recent studies reporting hormone levels related to thyroid gland function in migraineurs, until April 2020. Hormones (IF 1.962) Pub Date : 2020-07-15 Ali Seidkhani-Nahal,Asad Mirzaei,Gholam Basati,Davoud Parvizi-Faraz,Ali Noori-Zadeh
Purpose The purpose of the current study was to evaluate thyroid function in terms of serum thyroid-stimulating hormone (TSH, also known as thyrotropin), 3,5,3′-triiodo-l-thyronine (T3), and 3,5,3′,5′-tetraiodo-l-thyronine (T4, also known as thyroxine) levels in migraineurs in comparison with non-migraineurs using a systematic review of literature and a meta-analysis. Methods This is a systematic review
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Vitamin D and COVID-19. Hormones (IF 1.962) Pub Date : 2020-07-14 George Trovas,Symeon Tournis
Epidemiological data report that several countries with a high prevalence of hypovitaminosis D may have increased susceptibility to complications and mortality due to COVID-19 infection. These reports, however, have limitations given that they derive from observational studies. Nevertheless, while awaiting more robust data, clinicians should treat patients with vitamin D deficiency irrespective of
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Novel mutations of the LHCGR gene in two families with 46,XY DSD causing Leydig cell hypoplasia I. Hormones (IF 1.962) Pub Date : 2020-07-14 Heba Amin Hassan,M L Essawi,M K Mekkawy,I Mazen
Purpose Leydig cell hypoplasia is a rare autosomal recessive 46,XY disorder of sexual development (DSD). It is caused by homozygous or compound heterozygous inactivating mutations in the human luteinizing hormone/chorionic gonadotropin hormone receptor (LHCGR) gene. In Leydig cell hypoplasia type I, patients are characterized by predominantly female external genitalia, which usually go unrecognized
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Graves' hyperthyroidism-related pancytopenia: a case report with literature review. Hormones (IF 1.962) Pub Date : 2020-07-08 Lorenzo Scappaticcio,Giuseppe Bellastella,Maria Ida Maiorino,Miriam Longo,Claudia Catalano,Katherine Esposito,Giuseppe Paolisso,Maria Rosaria Rizzo
Introduction Occurrence of pancytopenia in patients with untreated hyperthyroidism is extremely rare. To the best of our knowledge, only 30 cases have been reported in the English literature. Accurate diagnosis and appropriate tailored therapy are challenging due to the variegated causes of pancytopenia and the potential hematological toxicity of antithyroid drugs (ATDs). Case report We present a 51-year-old
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Gender difference of association between plasma N-terminal pro-atrial natriuretic peptide and metabolic syndrome. Hormones (IF 1.962) Pub Date : 2020-07-03 Qianlan Guo,Qiu Zhang,Yan He,Jijun Shi,Hongmei Li,Hao Peng
Purpose The natriuretic peptides (NPs) system, and mainly atrial natriuretic peptide (ANP), plays a key role in human metabolism and cardiometabolic disorders. Due to differences in NP levels and in prevalence of metabolic syndrome (MetS) between men and women, we aimed to explore the gender difference of association between N-terminal pro-atrial natriuretic peptide (NT-proANP) and MetS in a general
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Reproductive health in women with type 2 diabetes mellitus. Hormones (IF 1.962) Pub Date : 2020-07-02 Doina Creţu,Simona Cernea,Corina Roxana Onea,Raluca-Monica Pop
As type 2 diabetes mellitus (T2DM) reaches epidemic proportions in the developed world and the age at diagnosis decreases, more women of reproductive age are being affected. In this article, we provide a synoptic view on potential mechanisms and relevant factors underlying menstrual cycle disorders and fertility issues in women with T2DM. The article discusses the function of the hypothalamic-pituitary-ovarian
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Correction to: Effect of selenium supplementation on antioxidant markers: a systematic review and meta-analysis of randomized controlled trials. Hormones (IF 1.962) Pub Date : 2020-07-01 Motahareh Hasani,Shirin Djalalinia,Maryam Khazdooz,Hamid Asayesh,Maryam Zarei,Armita Mahdavi Gorabi,Hossein Ansari,Mostafa Qorbani,Ramin Heshmat
The original version of this article, published on 10 December 2019 contained a mistake.
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Correlation of serum C1q-tumour necrosis factor-related protein 5 levels with metabolic parameters and carotid intima-media thickness in newly diagnosed type 2 diabetes mellitus patients. Hormones (IF 1.962) Pub Date : 2020-06-27 İ Merve B Uçar,Mehmet Çalan,Erhan Tatar,Roukie Chousein,Özge E Fenercioğlu,Giray Bozkaya,Arif Yüksel
Purpose Recent studies have shown that cytokines secreted from adipose tissues play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). CTRP5 (C1q-TNF-related protein 5) is a novel adipokine that has been shown to be associated with glucose and lipid metabolism. Varying levels of CTRP5 have been reported in individuals with diabetes, obesity and coronary artery disease. The aim of this study
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The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation. Hormones (IF 1.962) Pub Date : 2020-06-26 Feng Zhao,Xi Wang,Yan Wang,Jingbo Zhang,Ran Lai,Bei Zhang,Xueyan Zhou
BackgroundThe progression of endometrial cancer (EC) is closely related to estrogen levels. UDP-glucuronosyltransferases (UGTs) are an essential class of phase II metabolizing enzymes that play a pivotal role in detoxifying steroid hormone. PurposeIn this study, we aimed to uncover the role of UGTs in estrogen metabolism and the pathogenesis of EC. MethodsA total of 100 unrelated EC patients (mean
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The timing of fasting leads to different levels of food consumption and PYY3-36 in nocturnal mice. Hormones (IF 1.962) Pub Date : 2020-06-23 Marissa J Maroni,Kimberly M Capri,Alexis V Cushman,Hannah V Deane,Holly Concepcion,Holly DeCourcey,Joseph A Seggio
Purpose The daily circadian cycle is known to modulate both feeding behavior and metabolism. As such, the timing of food consumption can play a role in regulating overall health. The purpose of this study is to determine whether fasting at different times of the day alters subsequent food consumption and levels of PYY3–36, a hormone secreted after a meal which inhibits appetite. Methods Separate groups
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Seven cases of parathyroid carcinoma and review of the literature. Hormones (IF 1.962) Pub Date : 2020-06-23 Tugce Apaydın,Dilek Gogas Yavuz
Parathyroid cancer is a rare malignancy and an uncommon cause of hyperparathyroidism. In the present study, we present seven cases of parathyroid carcinoma. The female ratio was 5/7 (71.4%). Median age at diagnosis was 47 years, and median follow-up duration was 60 months (IQR 29–75). Mean calcium level at diagnosis was 12.7 mg/dL (range, 11.3–13.9), and mean parathormone level was 1115 ng/L (IQR 287–1470)
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Efficacy of sex hormone-binding globulin on predicting metabolic syndrome in newly diagnosed and untreated patients with polycystic ovary syndrome. Hormones (IF 1.962) Pub Date : 2020-06-20 Chen Fu,Chen Minjie,Zhang Weichun,Yin Huihuang,Chen Guishan,Huang Qingxia,Yang Xiaoping,Chen Lan,Wang Ping,Lin Chujia,Yin Guoshu
PurposeThe aims of this study were to investigate the correlation of sex hormone-binding globulin (SHBG) and the components of metabolic syndrome (MetS) and explore the ability of SHBG to predict MetS in newly diagnosed and untreated patients with polycystic ovary syndrome (PCOS). MethodsNinety-eight newly diagnosed and untreated patients with PCOS and 37 healthy volunteers were recruited. A receiver
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Association between HDL-C levels and menopause: a meta-analysis. Hormones (IF 1.962) Pub Date : 2020-06-18 Hongwei Li,Runlu Sun,Qian Chen,Qi Guo,Junjie Wang,Liming Lu,Yuling Zhang
Purpose Menopause modifies women’s lipid profiles. However, the fact that it is still unclear whether high-density lipoprotein-cholesterol (HDL-C) levels decrease in postmenopausal women necessitated a systematic review and meta-analysis. Methods The PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched and 498 articles published between 1987 and 2020 were retrieved. Studies
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Relative energy deficiency in sports (RED-S): elucidation of endocrine changes affecting the health of males and females. Hormones (IF 1.962) Pub Date : 2020-06-17 Konstantina Dipla,Robert R Kraemer,Naama W Constantini,Anthony C Hackney
The purpose of this review is to present a different perspective of the relative energy deficiency syndrome, to improve understanding of associated endocrine alterations, and to highlight the need for further research in this area. The term “female athlete triad” was coined over 25 years ago to describe three interrelated components: disordered eating, menstrual dysfunction, and low bone mass. The
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Estrogen and bones after menopause: a reappraisal of data and future perspectives. Hormones (IF 1.962) Pub Date : 2020-06-09 Panagiotis Anagnostis,Julia K Bosdou,Konstantina Vaitsi,Dimitrios G Goulis,Irene Lambrinoudaki
Menopausal hormone therapy (MHT) is effective in preventing menopause-related bone loss and decreasing vertebral, non-vertebral and hip fracture risk. MHT contains estrogens that exert both antiosteoclastic and osteoanabolic effects. These effects are dose-dependent, as even ultra-low doses preserve or increase bone mineral density. The transdermal route of administration is effective on cancellous
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Onset of Marine-Lenhart syndrome and Graves' ophthalmopathy in a female patient treated with alemtuzumab for multiple sclerosis. Hormones (IF 1.962) Pub Date : 2020-06-05 Rosario Le Moli,Marco Russo,Pasqualino Malandrino,Veronica Vella,Antonino Belfiore,Francesco Frasca
Background Immune checkpoint blockade therapy may lead to thyroid dysfunction in 3–7% of treated patients. Alemtuzumab is a CD52 inhibitor leading to thyroid dysfunction in approximately 40% of patients. A female patient was affected by multiple sclerosis (MS) and subclinical hyperthyroidism due to an autonomously functioning thyroid nodule (AFTN). After alemtuzumab treatment, she developed aggressive
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Consumers' attitude toward dietary supplements and functional food: a prospective survey in a Greek population sample. Hormones (IF 1.962) Pub Date : 2020-06-05 Evangelia Tsartsou,Nikolaos Proutsos,Iakovos Papadopoulos,Vangelis Tzouvelekas,Elias Castanas,Marilena Kampa
Purpose The main objective of the present study was to investigate the attitudes among a sample of educated Greek consumers toward the use of dietary supplements (DS) and functional foods (FF) given that attitudes and behaviors as regards DS/FF have not been sufficiently evaluated in Southern Europe, where their penetration is lower as compared to northern countries. Method An online questionnaire
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Type 2 diabetes mellitus management in patients with chronic kidney disease: an update. Hormones (IF 1.962) Pub Date : 2020-06-04 Zoi Kleinaki,Stella Kapnisi,Sofia-Andriani Theodorelou-Charitou,Ilias P Nikas,Stavroula A Paschou
Diabetes mellitus (DM) is a chronic multisystem disease. Diabetic nephropathy (DN) is one of its significant microvascular complications, associated with increased morbidity and mortality. The aim of this article is to review the literature regarding the latest advances in the management of type 2 DM (T2DM) in patients with chronic kidney disease (CKD). We initially refer to the screening guidelines
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Relationship of thyroid dysfunction with cardiovascular diseases: updated review on heart failure progression. Hormones (IF 1.962) Pub Date : 2020-06-02 Adel Abdel-Moneim,Asmaa M Gaber,Sherouk Gouda,Aya Osama,Sarah I Othman,Gamal Allam
Heart disease remains the leading cause of death globally. Heart failure (HF) is a clinical syndrome that results from impairment of the ability of the ventricle to fill with or eject blood. Over the past two decades, accumulated evidence has revealed the contribution of thyroid hormones to cardiovascular (CV) events, exerting their action through genomic and non-genomic pathways within the cardiomyocytes
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Psycho-neuro-endocrino-immunologic issues in multiple sclerosis: a critical review of clinical and therapeutic implications Hormones (IF 1.962) Pub Date : 2020-06-01 Maria Anagnostouli, Nikolaos Markoglou, George Chrousos
Multiple sclerosis (MS) is a multifactorial, chronic, immune-mediated, and neurodegenerative disease, having a well-known hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Several hormones have a great impact in the immune dysregulation, psychology, and cognitive status of patients with MS, as also in the fertility and response to treatment. In this comprehensive review, as an introduction, we
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Sexual dysfunction in polycystic ovary syndrome: a systematic review and meta-analysis. Hormones (IF 1.962) Pub Date : 2020-05-27 Huai Heng Loh,Anne Yee,Huai Seng Loh,Sharmilla Kanagasundram,Benedict Francis,Lee-Ling Lim
PurposePolycystic ovarian syndrome (PCOS) is a common disorder characterized by clinical or biochemical hyperandrogenism and ovulary dysfunction. Female sexual dysfunction (FSD) adversely affects quality of life and interpersonal relationships. We aimed to compare the prevalence of FSD in women with and without PCOS. MethodsWe pooled data from 28 observational studies involving 6256 women. Apart from
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Clinical practice guidelines on diabetes mellitus and pregnancy: ΙI. Gestational diabetes mellitus. Hormones (IF 1.962) Pub Date : 2020-05-25 Eleni Anastasiou,Georgios Farmakidis,Angeliki Gerede,Dimitrios G Goulis,Eftychia Koukkou,Anargyros Kourtis,Apostolos Mamopoulos,Kassiani Papadimitriou,Vasilios Papadopoulos,Theodoros Stefos
Gestational diabetes mellitus (GDM) is the most common metabolic disease of pregnancy and is associated with several perinatal complications. GDM is defined as diabetes diagnosed in the second or third trimester of pregnancy that was not clearly overt diabetes prior to gestation. In Europe, in 2016, the prevalence of GDM was estimated to be 5.4% (3.8–7.8). It varied depending on maternal age, year
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Insulin resistance, androgens, and lipids are gradually improved in an age-dependent manner in lean women with polycystic ovary syndrome: insights from a large Caucasian cohort. Hormones (IF 1.962) Pub Date : 2020-05-25 S Livadas,D Macut,C Bothou,J Kuliczkowska-Płaksej,A Vryonidou,J Bjekic-Macut,Z Mouslech,A Milewicz,D Panidis
Purpose Polycystic ovary syndrome (PCOS), considered a lifelong condition, manifests mainly as a cluster of hyperandrogenic symptoms during the early reproductive years, with the affected woman gradually developing an adverse cardiometabolic profile over the years. However, some data point to the possibility of differences in the evolution of PCOS according to a woman’s weight. The aim of the present
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Is there an association between serum 25(OH)D3 and mental well-being in patients with type 2 diabetes? Results from a cohort study in primary care. Hormones (IF 1.962) Pub Date : 2020-05-21 Maria Samefors,Robert Scragg,Fredrik H Nystrom,Carl Johan Östgren
PurposeThere are limited and inc