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Resveratrol Shows Potent Senescence Reversal in Experimental Cellular Models of Particular Matter 2.5-induced Cellular Senescence in Human Dermal Papilla Cells. In Vivo (IF 2.3) Pub Date : 2024-2-29 Zin Zin Ei, Thunwadee Srithawirat, Preedakorn Chunhacha, Chatchai Chaotham, Wanatchaporn Arunmanee, Preeyaphan Phookphan, Pithi Chanvorachote
Particular matter 2.5 (PM2.5) pollution is associated with senescence induction. Since the impact of PM2.5 on stem cell senescence and potential compounds capable of reversing this process are largely unknown, this study aimed to examine the senescence effects of PM2.5 on dermal papilla (DP) stem cells. Additionally, we explored the reversal of these effects using natural product-derived substances
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Analysis of Factors Related to Gastroesophageal Reflux After Gastric Bypass at 10-Year Follow-up: A Retrospective Single-institutional Study. In Vivo (IF 2.3) Pub Date : 2024-2-29 Niccolò Petrucciani, Marine Benois, Paolo Aurello, Hubert Boudrie, Olivier VAN Haverbeke, Sara Claudia Barone, Francesco Martini, Arnaud Liagre
Long-term gastroesophageal reflux (GERD) after gastric bypass for obesity is underestimated. The present study aimed to evaluate the rate of treated GERD and the factors influencing it in a cohort of patients who underwent gastric bypass.
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Investigation of Expanded Human Adipose-derived Stem Cell Dosage and Timing for Improved Defecation Function. In Vivo (IF 2.3) Pub Date : 2024-2-29 Ryota Mori, Norikatsu Miyoshi, Shiki Fujino, Tsunekazu Mizushima, Ryohei Yukimoto, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi
Although certain treatment options exist for intestinal incontinence, none are curative. Adipose-derived stem cells (ADSCs) have emerged as promising therapeutic agents, but most preclinical studies of their effectiveness for anal function have used autologous or allogeneic ADSCs. In this study, the effectiveness, timing of administration, and required dosage of human ADSCs were investigated for clinical
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Perinatal Outcome in Pregnant Women With Isolated Oligohydramnios Diagnosed With the Single Deepest Pocket Method. In Vivo (IF 2.3) Pub Date : 2024-2-29 Ulf Dammer, Jutta Pretscher, Christel Weiss, Michael Schneider, Florian Faschingbauer, Matthias W Beckmann, Sven Kehl
The aim of this study was to investigate perinatal outcome in singleton pregnancies at term with isolated oligohydramnios, diagnosed by using the single deepest pocket method.
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D3 Lymph Node Dissection Improves Survival Outcomes in Patients With cT2 Colorectal Non-well-differentiated Adenocarcinoma. In Vivo (IF 2.3) Pub Date : 2024-2-29 Liming Wang, Bolun Song, Yinggang Chen, Yasumitsu Hirano
The extent of lymphadenectomy appropriate for patients with cT2 colorectal cancer (CRC) remains controversial. This study was conducted to compare the survival outcomes of patients with cT2 CRC after D3 or D2 lymph node dissection (LND).
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Clinical Benefits of Oral Anticoagulants for Elderly Patients With Cardioembolic Stroke at High Bleeding Risk. In Vivo (IF 2.3) Pub Date : 2024-2-29 Kazumasa Saito, Joji Hagii, Takanobu Soma, Shota Washima, Natsumi Yamada, Hiroshi Shiroto, Shin Saito, Takaatsu Kamada, Shingo Takanashi, Hirofumi Tomita
The relationship between the severity of cardioembolic stroke (CES) and oral anticoagulant (OAC) treatment before stroke onset in very elderly (≥80 years) patients with nonvalvular atrial fibrillation (NVAF) at high bleeding risk remains unknown.
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Growth Patterns of Prostate Cancers Undetected by Prostate 3T Multiparametric MRI. In Vivo (IF 2.3) Pub Date : 2024-2-29 Kai-Po Chang, Po-Fan Hsieh, Wei-Ching Lin, Han Chang
The multiparametric magnetic resonance imaging (mpMRI)-ultrasound (US) fusion targeted biopsy (TB) is a useful diagnostic device for men with suspected prostate cancer (PC) and can increase the detection rate for clinically significant PCs (csPC). However, few studies have shown pathological findings of undetectable csPCs on the prostate mpMRI.
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Intestinal "Piggybacking Lipoma", A Unique Lipoma Composed of Lipoma and Overlying Epithelial Lesions: A Case-control Study and Review of Literature. In Vivo (IF 2.3) Pub Date : 2024-2-29 Madhurya Ramineni, Mark Ettel, Xiaoyan Liao, Yansheng Hao
Lipomas are rare but the most common benign mesenchymal lesions of the gastrointestinal (GI) tract, composed of mature adipose cells. The "piggybacking lipoma" is formed by lipomas with overlying polypoid epithelial lesions, such as sessile serrated lesion, tubular adenoma, or hyperplastic polyp, and the literature on these lesions is limited. In this study, we systematically investigated the clinical
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Adenosine Deaminase Family Acting on RNA 1 (ADAR1) May Be a De Novo Target for Endometriosis Treatment. In Vivo (IF 2.3) Pub Date : 2024-2-29 Thuy Ha Vu, Keiichiro Nakamura, Kunitoshi Shigeyasu, Kotaro Kubo, Chiaki Kashino, Hisashi Masuyama
Adenosine deaminase family acting on RNA 1 (ADAR1) expression was examined to determine its correlation with endometriosis. The biological functions and inhibitory effects of ADAR1 knockdown were investigated in a human endometriotic cell line.
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Impact of the Corona Pandemic on Cervical Cancer Screening Assessment. In Vivo (IF 2.3) Pub Date : 2024-2-29 Frederik A Stuebs, Annika S Behrens, Anja Seibold, Werner Adler, Carol Geppert, Arndt Hartmann, Antje Knöll, Martin C Koch, Grit Mehlhorn, Matthias W Beckmann, Anna-Katharin Theuser, Carla E Schulmeyer, Paul Gass, Anna K Dietl
The global impact of the COVID-19 pandemic resulted in disruptions to healthcare systems throughout the world. The numbers of cytology examinations, human papillomavirus (HPV) tests, and women referred for colposcopy decreased in many countries. There have been no reports on cervical cancer screening in Germany. This study aimed to describe changes in the numbers of colposcopies, cytology examinations
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Association of Nutritional Indices With Adverse Effects and Time-to-Treatment-Failure in Triple Therapy for Lung Cancer. In Vivo (IF 2.3) Pub Date : 2024-2-29 Yasuhisa Hashino, Takumu Matushita, Tae Hatsuyama, Azusa Wakamoto, Keisuke Goto, Takanobu Hoshi, Kuninori Iwayama, Koichi Ohtaki, Takaki Toda, Hideki Sato
Recent lung cancer treatments include an immune checkpoint inhibitor (ICI) pembrolizumab, platinum-based agents, plus an additional cytotoxic anticancer agent. Nutritional indices, such as the geriatric nutritional risk index (GNRI) and the prognostic nutritional index (PNI), are known to correlate with the prognosis of cancer chemotherapy. Several previous studies have investigated the relationship
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Occurrence of Colorectal Cancer After a Negative Colonoscopy in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. In Vivo (IF 2.3) Pub Date : 2024-2-29 Giorgia Burrelli Scotti, Immacolata Iannone, Cristina DE Padua, Daniele Crocetti, Giulia Fiori, Paolo Sapienza, Enrico Fiori, Stefano Avenia, Antonietta Lamazza
Despite the application of colorectal cancer (CRC) surveillance guidelines, the detection of early neoplastic lesions might be difficult in patients with inflammatory bowel disease (IBD). To explore the risk of post-colonoscopy CRC (PCCRC) in patients with IBD we performed a systematic review and meta-analysis.
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Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors and Hypothyroidism: An Analysis of the Japanese Pharmacovigilance Database. In Vivo (IF 2.3) Pub Date : 2024-2-29 Hiroyuki Tanaka, Alicia Tani, Toshihisa Onoda, Toshihiro Ishii
Hypothyroidism induced by roxadustat, a hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor, was recently reported; however, information regarding roxadustat-associated hypothyroidism is still lacking. We explored the risk and time to onset of hypothyroidism associated with HIF-PH inhibitors using the Japanese Adverse Drug Event Report (JADER), a pharmacovigilance database.
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Kv 11.1 Expression Is Associated With Malignancy of Canine Mammary Gland Tumors. In Vivo (IF 2.3) Pub Date : 2024-2-29 Nuri Lee, Sungin Lee, Wanhee Kim
The expression level of the voltage-dependent potassium channel Kv 11.1 was shown to be associated with the clinicopathological features, aggressiveness, and prognosis of human breast cancer. Canine mammary gland tumor (cMGT) is the most common tumor type in intact female dogs; however, the significance of Kv 11.1 in cMGT is unknown. The aim of this study was to identify Kv 11.1 expression in 57 benign
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Retinopathy in a Patient With IgM MGUS: Causal Association or an Epiphenomenon? In Vivo (IF 2.3) Pub Date : 2024-2-29 Ioannis Ntanasis-Stathopoulos, Efstathios Kastritis, John Tzartos, Evangelos Terpos, Meletios A Dimopoulos, Maria Gavriatopoulou
The presence of a monoclonal gammopathy of undetermined significance (MGUS) even in small amounts may trigger tissue damage through immunological or other mechanisms, irrespective of the potential for malignant transformation. The aim of the study was to present a case of monoclonal gammopathy of clinical significance with ocular manifestations and discuss relevant literature.
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Acceptability, Safety, and Feasibility of Transnasal and Peroral Ultrathin Endoscopy Using GAGLESS Mouthpieces: A Prospective Randomized Trial. In Vivo (IF 2.3) Pub Date : 2024-2-29 Kazuya Matsumoto, Atsushi Imagawa, Naoki Ueda, Hirotsugu Watabe, Yuichiro Ikebuchi, Hiroki Kurumi, Y U Sasaki, Yasuhiko Abe, Ryo Abe, Katsuhiro Mabe, Hisashi Noma, Kazunori Fujiwara, Masaru Ueki, Mitsuhiro Fujishiro, Hajime Isomoto
Esophagogastroduodenoscopy (EGD) is an effective screening method for early detection of gastric cancer. The GAGLESS mouthpiece has a structure that widens the pharyngeal cavity and suppresses the pharyngeal reflex. This study aimed to investigate the acceptability, safety, and feasibility of transnasal and peroral ultrathin endoscopy using GAGLESS mouthpieces (Clinical Trial Number: UMIN000036922)
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Retrospective Analysis of Definitive Chemoradiotherapy With FOLFOX in Patients With Esophageal Cancer Intolerant to Cisplatin. In Vivo (IF 2.3) Pub Date : 2024-2-29 Mayu Yada, Shun Yamamoto, Yoshitaka Honma, Hidekazu Hirano, Natsuko Okita, Hirokazu Shoji, Satoru Iwasa, Atsuo Takashima, Akihito Nagahara, Ken Kato
Definitive chemoradiotherapy with cisplatin (CDDP) plus 5-fluorouracil is the standard treatment for locally advanced esophageal squamous cell carcinoma (LA-ESCC); however, CDDP is unsuitable for patients with cardiac and/or renal dysfunction. Based on the results of the PRODIGE5/ACCORD17 trial, 5-fluorouracil and leucovorin with oxaliplatin plus radiotherapy (FOLFOX-RT) has been recognized as a treatment
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Surgical Reconstruction of Canine Nonunion Fractures Using Bone Morphogenetic Protein-2-loaded Alginate Microbeads and Bone Allografts. In Vivo (IF 2.3) Pub Date : 2024-2-29 Seoyun Lee, Byung-Jae Kang
Effective treatment of nonunion fractures is challenging as it requires a biological and mechanical environment to promote sufficient osteogenesis. Herein, we present a case series in which we evaluated the clinical efficacy of bone morphogenetic protein-2 (BMP-2)-loaded alginate microbeads and allografts in two dogs with nonunion fractures.
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Efficacy of Platinum-based Chemotherapy in Patients With Metastatic Urothelial Carcinoma With Variant Histology. In Vivo (IF 2.3) Pub Date : 2024-2-29 Akinori Minato, Kazuki Murooka, Yutaka Okumura, Tomohisa Takaba, Katsuyoshi Higashijima, Yujiro Nagata, Ikko Tomisaki, Kenichi Harada, Naohiro Fujimoto
Variant urothelial carcinoma (VUC, defined herein as urothelial carcinoma with any histological variant) is frequently observed at an advanced stage. However, the efficacy of systemic chemotherapy against VUC in metastatic disease has rarely been reported. This study assessed the therapeutic response and survival outcomes of platinum-based chemotherapy as first-line treatment in patients with metastatic
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Clinical Impact of the C-reactive Protein-albumin-lymphocyte Index in Post-gastrectomy Patients With Gastric Cancer. In Vivo (IF 2.3) Pub Date : 2024-2-29 Itaru Hashimoto, Mie Tanabe, Shizune Onuma, Jyunya Morita, Shinsuke Nagasawa, Yukio Maezawa, Kyohei Kanematsu, Toru Aoyama, Takanobu Yamada, Norio Yukawa, Takashi Ogata, Yasushi Rino, Aya Saito, Takashi Oshima
Recently, preoperative inflammatory, immune, and nutritional statuses have attracted attention as prognostic factors in post-curative gastrectomy patients with gastric cancer (GC). The usefulness of the C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic factor in patients with various cancers, has been reported. However, reports on the clinical significance of the CALLY index in patients
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The Naples Prognostic Score Is an Independent Prognostic Factor for Gastric Cancer Patients Who Receive Curative Treatment. In Vivo (IF 2.3) Pub Date : 2024-2-29 Toru Aoyama, Aya Kato, Itaru Hashimoto, Yukio Maezawa, Kentaro Hara, Keisuke Kazama, Keisuke Komori, Hiroshi Tamagawa, Ayako Tamagawa, Shinsuke Nagasawa, Haruhiko Cho, Kenki Segami, Masato Nakazono, Kazuki Otani, Sho Sawazaki, Masakatsu Numata, Natsumi Kamiya, Suzue Yoshizawa, Shinnosuke Kawahara, Takashi Oshima, Aya Saito, Norio Yukawa, Yasushi Rino
This study aimed to evaluate the clinical impact of the Naples Prognostic Score (NPS) in patients with gastric cancer and to clarify the potential of the NPS as a nutritional and inflammation evaluation system.
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Transient Worsening of Pain After Administration of Immune Checkpoint Inhibitors - A Case Series. In Vivo (IF 2.3) Pub Date : 2024-2-29 Yasumasa Saito, Junya Sato, Tokiwa Takeshima, Hiroki Kase
Transient pain enhancement or flare pain, is observed following the administration of immune checkpoint inhibitors (ICIs). However, the detailed mechanism of this phenomenon remains unclear. In this report, we present our experience of documenting the course of flare pain following ICI administration in six cases.
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Correlation Between Dosimetric Parameters and Local Control in Definitive Radiotherapy for Head and Neck Cancers. In Vivo (IF 2.3) Pub Date : 2024-2-29 Mikiko Yamashita, Shingo Ohira, Hiroaki Tanabe, Masaki Kokubo, Masahiko Koizumi
Radiotherapy (RT) outcomes are generally reported based on stage, patient background, and concomitant chemotherapy. This study aimed to investigate the effects of the prescribed dose to gross tumor volume (GTV) and the calculation algorithm on local control in definitive RT for head and neck (H&N) cancers using follow-up images after RT.
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Postoperative Scar Management Using Laser Therapy for Breast Reconstruction With Latissimus Dorsi Flap. In Vivo (IF 2.3) Pub Date : 2024-2-29 Joon Seok Lee, Hyun Su Kang, Jongmoo Park, Jeong Yeop Ryu, Kang Young Choi, Ho Yun Chung, Byeongju Kang, Jeeyeon Lee, Ho Yong Park, Jung Dug Yang
Postoperative scar formation is inevitable, and a gold standard management has not been established to date. Due to the fact long and large scar formation occurs in reconstructive surgery, this study analyzed the relationship between various factors in patients who received breast reconstruction using latissimus dorsi (LD) flap to investigate appropriate and effective management approaches.
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Unraveling the Impact of miRNA-17 in Glial Tumors and Cerebral Metastases: A Step Towards Enhanced Diagnosis and Prognosis. In Vivo (IF 2.3) Pub Date : 2024-2-29 Okan Türk, Nail Demirel, Cumhur Kaan Yaltirik, Mustafa Kaya, Ömer Faruk Şahin, Seda Güleç Yilmaz, Fatma Tuba Akdeniz, Turgay Isbir
MicroRNAs (miRNAs) have been identified as key regulators in various cancer types, including brain tumors. This study aimed to investigate the differential expression of miRNA-17 in glial tumors, cerebral metastases, and normal glial tissues.
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Atypical Acute Neuroborreliosis With Leg Paresis and Constipation. In Vivo (IF 2.3) Pub Date : 2024-2-29 Hannes Ahrend, Christiane Fibbe, Dorothea Jasper, Anne Ahrend, Michael Woelfel, Peter Layer, Ulrich Rosien, Matthias B Stope
An 80-year-old male patient had complained of proximal paresis of the left leg, pain and sensory disturbances in the left abdomen, exanthema in the left lower abdomen, coprostasis, and severe abdominal pain, as well as a progressive deterioration of his general condition for weeks. The patient had already presented to three other medical centers. Colonoscopy and computed tomography of the abdomen could
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A Case Study of Vitamin D Supplementation Therapy and Acute Respiratory Tract Infection. In Vivo (IF 2.3) Pub Date : 2024-2-29 Vaclav Simanek, Eva Dedeckova, Ondrej Topolcan, Marketa Kralova, Radek Kucera
Low serum concentrations of 25-hydroxyvitamin D correlate with higher susceptibility to acute respiratory tract infections (ARTIs). The case study presented here aims at sheding light on the correlation between vitamin D levels, the vitamin D supplement dose, and the incidence of ARTIs.
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Cytomegalovirus Occurrence and Time-to-onset Analysis Under Bendamustine With Anti-CD20 Antibodies Using the JADER Database. In Vivo (IF 2.3) Pub Date : 2024-2-29 Kaori Ito, Takenao Koseki, Misaki Morisaku, Shigeki Yamada, Nobuki Hayakawa
Patients with malignant lymphoma, in a latent state of weakened immune function, are at risk of chemotherapy-induced immunosuppression and cytomegalovirus (CMV) infection. Concomitant therapy with bendamustine and rituximab or obinutuzumab intensifies immunosuppression, potentially affecting CMV onset. This study aimed to assess CMV onset differences between bendamustine monotherapy and combination
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Cisplatin Induces Kidney Cell Death via ROS-dependent MAPK Signaling Pathways by Targeting Peroxiredoxin I and II in African Green Monkey (Chlorocebus aethiops sabaeus) Kidney Cells. In Vivo (IF 2.3) Pub Date : 2024-2-29 Hui-Na Zhang, Wan-Qiu Xiao, Dong Hun Lee, Nan Li, Yao-Yuan Feng, Ting Su, Han-Yu Gu, Ijoo Yoon, Haiyoung Jung, Kyung Ho Lee, Hee Jun Cho, Ying-Hao Han, Hu-Nan Sun, Taeho Kwon
Cisplatin [cis-diamminedichloroplatinum(II), CDDP] is a widely used and effective antitumor drug in clinical settings, notorious for its nephrotoxic side effects. This study investigated the mechanisms of CDDP-induced damage in African green monkey kidney (Vero) cells, with a focus on the role of Peroxiredoxin I (Prx I) and Peroxiredoxin II (Prx II) of the peroxiredoxin (Prx) family, which scavenge
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Effect of Liver Dysfunction on S-1 Therapy Induced Adverse Effects: A Retrospective Cohort Study. In Vivo (IF 2.3) Pub Date : 2024-2-29 Yosuke Ando, Yuki Shibata, Takuma Ishihara, Seira Nishibe-Toyosato, Kaori Ito, Nanaho Miyata-Hiraga, Kenji Kawada, Yoshiaki Ikeda, Takahiro Hayashi, Kazuyoshi Imaizumi, Shigeki Yamada
Renal dysfunction necessitates S-1 dose reduction. However, decreased dihydropyrimidine dehydrogenase (DPD) activity may lead to adverse events due to 5-FU. The guidelines provided by pharmaceutical companies state that total bilirubin (T-Bil) should be ≤upper limit of normal (ULN)×1.5 as a reference value for safely taking S-1. Nevertheless, the relationship between the degree of liver dysfunction
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Intramuscular Hybrid Nerve Sheath Tumor of the Thigh: Case Report and Literature Review. In Vivo (IF 2.3) Pub Date : 2024-2-29 Yoshiro Chijiiwa, Junya Sano, Kazuhiko Okamura, Jun Nishio
Hybrid nerve sheath tumor (HNST) is a benign peripheral nerve sheath tumor with combined features of more than one histological type, such as schwannoma, neurofibroma, and perineurioma. It remains under-recognized in routine clinical practice. Herein, we describe an unusual case of intramuscular HNST of the thigh.
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Concomitant [18F]F-FAZA and [18F]F-FDG Imaging of Gynecological Cancer Xenografts: Insight into Tumor Hypoxia. In Vivo (IF 2.3) Pub Date : 2024-2-29 Zita Kepes, Eva Hegedus, Tamas Sass, Csaba Csikos, Judit P Szabo, Viktoria Szugyiczki, István Hajdu, Istvan Kertesz, Gabor Opposits, Jozsef Imrek, Laszlo Balkay, Ferenc Krisztián Kalman, Gyorgy Trencsenyi
Herein we assessed the feasibility of imaging protocols using both hypoxia-specific [18F]F-FAZA and [18F]F-FDG in bypassing the limitations derived from the non-specific findings of [18F]F-FDG PET imaging of tumor-related hypoxia.
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Clinical Relevance of Differential RARα and PPARβ/δ Expression in Myelodysplastic Syndromes. In Vivo (IF 2.3) Pub Date : 2024-2-29 Nikolay Kalitin, Galina Dudina, Natalia Kostritsa, Anastasiya Sivirinova, Andrey Vaiman, Aida Karamysheva
Myelodysplastic syndromes (MDS) are clinically heterogeneous hematological malignancies with an increased risk of transformation to acute myeloid leukemia, emphasizing the importance of identifying new diagnostic and prognostic markers. This study sought to investigate the predictive ability of all-trans retinoic acid (ATRA)-dependent nuclear transcription factors RARα and PPARβ/δ gene expression in
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Bifico Ameliorates Neurological Deficits After Ischemic Stroke in Mice: Transcriptome Profiling. In Vivo (IF 2.3) Pub Date : 2024-2-29 Yanfei Han, Huizhen Xu, Shaoxin Tao, Yanbing Zhu, Zheng Z Wei, Yingying Zhao, Yongbo Zhang
Evidence suggests that gut microbiota can affect various neurological diseases, including stroke. Stroke patients have an increase in harmful gut bacteria and a decrease in beneficial bacteria. This increases intestinal permeability, increases the risk of infection, and even affects many inflammatory factors. While probiotics may affect stroke prognosis by improving the gut environment. This study
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The Clinical Benefit of the Modified Neutrophil-Platelet Score as a Surrogate Prognostic Marker in Patients With Resectable Gastric Cancer. In Vivo (IF 2.3) Pub Date : 2024-2-29 Kazuki Otani, Toru Aoyama, Yukio Maezawa, Itaru Hashimoto, Natsumi Kamiya, Aya Kato, Masakatsu Numata, Shinnosuke Kawahara, Ayako Tamagawa, Masato Nakazono, Hiroshi Tamagawa, Kenki Segami, Keisuke Kazama, Sho Sawazaki, Norio Yukawa, Aya Saito, Yasushi Rino
Gastric cancer is a common cause of cancer death worldwide, especially in East Asia. This study evaluated the impact of preoperative modified Neutrophil-Platelet Score (mNPS) on the survival and recurrence of patients with resectable gastric cancer.
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Nivolumab Rechallenge After Immune-related Adverse Events in Patients With Unresectable Advanced or Recurrent Esophageal Cancer. In Vivo (IF 2.3) Pub Date : 2024-2-29 Kohdai Ueno, Kunihito Suzuki, Katsumasa Saito, Hajime Shinohara, Akinori Miura
Rechallenge with immune checkpoint inhibitors following immune-related adverse events (irAEs) during the treatment of certain cancers reportedly has good efficacy. However, the subsequent clinical course of esophageal cancer remains unclear. This study investigated the nature of irAEs and the efficacy of a nivolumab rechallenge for patients with esophageal cancer.
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Temporalis Flap for Soft Palate Reconstruction - More than an Alternative for Patients Unsuitable for Microvascular Reconstructive Surgery. In Vivo (IF 2.3) Pub Date : 2024-2-29 Florian Dudde, Filip Barbarewicz, Kai-Olaf Henkel
The treatment of squamous cell carcinoma (SCC) in the oral cavity for operable patients usually consists of surgical tumor resection, unilateral or bilateral neck dissection and defect reconstruction. In addition to local flaps, multiple, particularly microsurgical, distant flaps have been developed, which are mainly considered state of the art reconstruction. However, depending on previous operations
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Albumin-Globulin Ratio Is an Independent Prognostic Factor for Gastric Cancer Patients who Received Curative Treatment. In Vivo (IF 2.3) Pub Date : 2024-2-29 Momoko Fukuda, Toru Aoyama, Itaru Hashimoto, Yukio Maezawa, Aya Kato, Kentaro Hara, Keisuke Kazama, Keisuke Komori, Ayako Tamagawa, Haruhiko Cho, Tetsushi Ishiguro, Kenki Segami, Masato Nakazono, Kazuki Otani, Sho Sawazaki, Masakatsu Numata, Shinnosuke Kawahara, Takashi Oshima, Aya Saito, Norio Yukawa, Yasushi Rino
The albumin-globulin ratio (AGR) is a useful biomarker for predicting postoperative complications and a poor prognosis in patients with various types of cancer and can be evaluated without invasive testing or surgery. In this study, we aimed to evaluate the usefulness of the AGR in predicting the short- and long-term prognoses of patients with gastric cancer who underwent radical resection at our institution
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Real-time Histological Evaluation of Gastric Cancer Tissue by Using a Confocal Laser Endomicroscopic System. In Vivo (IF 2.3) Pub Date : 2024-2-29 Hyunsik Bae, Haeyon Cho, Yeonju Jo, So Mi Heo, Jinah Chu, Sangjoon Choi, Kyungmin Hwang, Kyuyoung Kim, Seokhwi Kim
The need for instant histological evaluation of fresh tissue, especially in cancer treatment, remains paramount. The conventional frozen section technique has inherent limitations, prompting the exploration of alternative methods. A recently developed confocal laser endomicroscopic system provides real-time imaging of the tissue without the need for glass slide preparation. Herein, we evaluated its
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Effectiveness of Bach Nien Kien Health Supplement in the Treatment of Patients With Symptomatic Knee Osteoarthritis. In Vivo (IF 2.3) Pub Date : 2024-2-29 Hoan M Vu, Hau D Tran, Anh K Nguyen, B O Han, Ba X Hoang
Knee osteoarthritis (KOA) is the most common disease in adults. We conducted a clinical study to evaluate the efficacy and safety of Bach Nien Kien (BNK) in supportive therapy for patients with symptomatic KOA.
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Artificial Intelligence (AI) Based Analysis of In Vivo Polymers and Collagen Scaffolds Inducing Vascularization. In Vivo (IF 2.3) Pub Date : 2024-2-29 Enrica Raffaella Grazia Salvante, Anca Voichita Popoiu, Alina Cristina Barb, Andrei Alexandru Cosma, Mihaela Pasca Fenesan, Amulya K Saxena, Tudor Alexandru Popoiu, Eugen Sorin Boia, Maria Corina Stanciulescu, Borislav Dusan Caplar, Florica Ramona Dorobantu, Anca Maria Cimpean
Biomaterials are essential in modern medicine, both for patients and research. Their ability to acquire and maintain functional vascularization is currently debated. The aim of this study was to evaluate the vascularization induced by two collagen-based scaffolds (with 2D and 3D structures) and one non-collagen scaffold implanted on the chick embryo chorioallantoic membrane (CAM).
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Involvement of NOTCH1-mediated Microglia Activation in Neuromodulation of Chronic Prostatitis-related Pain. In Vivo (IF 2.3) Pub Date : 2024-2-29 Heng Zhang, Ruifen Gu, Jisheng Luo, Chuanhua Zhong, Jinhong Pan
This study aimed to investigate the role of NOTCH receptor 1 (NOTCH1)-mediated activation of microglia in the L5-S2 spinal dorsal horn in chronic prostatitis pain.
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Evaluation of Prediabetes in Cisplatin-induced Nephrotoxicity in the Short Hydration Method: A Subgroup Analysis. In Vivo (IF 2.3) Pub Date : 2024-2-29 Yoshitaka Saito, Tatsuhiko Sakamoto, Masaki Kobayashi, Yoh Takekuma, Issei Higuchi, Keisuke Okamoto, Jun Sakakibara-Konishi, Yasushi Shimizu, Ichiro Kinoshita, Mitsuru Sugawara
Cisplatin-induced nephrotoxicity (CIN) is one of the most attention-requiring adverse effects. We have reported that diabetes mellitus significantly increases the incidence of CIN in a short hydration method in real-world lung cancer treatment. However, the effect of prediabetes on CIN development remains unclear. This study investigated whether patients with prediabetes exhibit CIN at a greater rate
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In Vivo Genotoxicity and Cytotoxicity Kinetics of Trimethoprim Sulfamethoxazole in Well-nourished and Undernourished Young Rats. In Vivo (IF 2.3) Pub Date : 2024-2-29 Rocío Ortiz-Muñiz, Elsa Cervantes-Ríos, Catalina Soriano-Correa, Linda Campos-Fernández, Leonor Rodríguez-Cruz, Edith Cortés-Barberena, Pedro Morales-Ramírez
Undernutrition is a serious health problem prevalent in poor countries, affecting millions of people worldwide, especially young children, pregnant women, and sick elderly individuals. This condition increases vulnerability to infections, leading to widespread use of antibiotic treatments in undernourished populations. The objective of the present study was to determine the in vivo genotoxic and cytotoxic
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Contribution of Matrix Metalloproteinase-2 Genotypes to Taiwan Pterygium Risk. In Vivo (IF 2.3) Pub Date : 2024-2-29 Pei-Shin Hu, Ning-Yi Hsia, Zhi-Hong Wang, Hung-Chih Chen, Te-Chun Hsia, Meng-Liang Lin, Yun-Chi Wang, Wen-Shin Chang, DA-Tian Bau, Chia-Wen Tsai
In the literature, the studies about the role of matrix metalloproteinase-2 (MMP-2) in pterygium diagnosis are mainly based on its protein expression. The role of MMP-2 variants has never been examined. The aim of this study was to examine the association of MMP-2 genotypes with pterygium risk.
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Development of a Simple and Reproducible Cell-derived Orthotopic Xenograft Murine Model for Neuroblastoma. In Vivo (IF 2.3) Pub Date : 2024-2-29 Kathleen Doyle, Abd-Elrahman Hassan, Maria Sutter, Monica Rodriguez, Priyadarsini Kumar, Erin Brown
Neuroblastoma is a common childhood cancer with poor survival for children with high-risk disease, and ongoing research to improve outcomes is needed. Patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM) are reliable models for oncologic research; however, they are resource-intensive, expensive, and require significant expertise to develop and maintain. We developed an orthotopic
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Zinc Alpha-2 Glycoprotein, Acylated Ghrelin, and Zinc Levels in Prediabetics. In Vivo (IF 2.3) Pub Date : 2024-2-29 Eda Merve Kurtuluş, Denizhan Kariş, Alev Meltem Ercan, Dildar Konukoğlu
Prediabetic stages of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) exhibit differences in the sites of insulin resistance. Serum Zinc α-2 glycoprotein (ZAG), acylated ghrelin (AG), and zinc (Zn) levels can affect IFG, IGT, and diabetic glucose tolerance (DGT) differently. This study examined the importance of ZAG, AG, and serum Zn levels in prediabetic individuals with IFG, IGT
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External Volume Expansion: Timing and Effects on the Rate of Fat Graft Retention in BALB/c Nude Mice. In Vivo (IF 2.3) Pub Date : 2024-2-29 Yong June Chang, Yun Hyun Kim, Joon Seok Lee, Jeong Yeop Ryu, Kang Young Choi, Ho Yun Chung, Byung Chae Cho, Jung Dug Yang
Fat grafting has been widely used for soft-tissue augmentation. External volume expansion (EVE) is a favorable tool for improvement in the rate of fat graft retention. However, few studies have focused on the most appropriate time for its implementation. In this study, BALB/c nude mice were used to investigate the effective time for the implementation of external volume expansion to improve the rate
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In Vivo Evaluation of Brain [18F]F-FDG Uptake Pattern Under Different Anaesthesia Protocols. In Vivo (IF 2.3) Pub Date : 2024-2-29 Zita Kepes, Viktória Arato, Csaba Csikos, Eva Hegedus, Regina Esze, Tamas Nagy, Istvan Joszai, Miklos Emri, Istvan Kertesz, Gyorgy Trencsenyi
Since the use of anaesthetics has the drawback of altering radiotracer distribution, preclinical positron emission tomography (PET) imaging findings of anaesthetised animals must be carefully handled. This study aimed at assessing the cerebral [18F]F-FDG uptake pattern in healthy Wistar rats under four different anaesthesia protocols using microPET/magnetic resonance imaging (MRI) examinations.
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Serum CCDC25 Levels as a Potential Marker for Metabolic Syndrome. In Vivo (IF 2.3) Pub Date : 2024-2-29 Anousone Phimphila, Tin May Aung, Molin Wongwattanakul, Pornsuda Maraming, Ratree Tavichakorntrakool, Tanakorn Proungvitaya, Jureerut Daduang, Siriporn Proungvitaya
Metabolic syndrome (MetS) stands as a significant risk for developing various severe health problems. Therefore, the discovery of biomarkers capable of predicting the progression of metabolic conditions is crucial for improving overall health outcomes. Recently, we reported that coiled-coil domain containing 25 (CCDC25) might be associated with key proteins involved in metabolic pathways, by bioinformatics
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Immunophenotypes and Tumor Immune Microenvironment in Hepatocellular Carcinoma With Macrotrabecular Massive and Vessels Encapsulating Tumor Clusters. In Vivo (IF 2.3) Pub Date : 2024-2-29 Jun Akiba, Masamichi Nakayama, Reiichiro Kondo, Hironori Kusano, Sachiko Ogasawara, Yutaro Mihara, Masahiko Tanigawa, Kana Tsutsui, Yuta Yano, Daiki Miyazaki, Saeko Tokisawa, Toshiyuki Mitsuhashi, Hidetoshi Nomura, Sakiko Sanada, Hisamune Sakai, Toru Hisaka, Hirohisa Yano
Recently, vessels encapsulating tumor clusters (VETC) pattern and macrotrabecular massive (MTM) pattern of hepatocellular carcinoma (HCC) have been reported as aggressive histological types. These histological patterns showed an immunosuppressive tumor immune microenvironment (TIME). Since there have been no reports on the differences of these two subtypes simultaneously, this study examined the immunophenotypes
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Survival Predictors Before Preoperative Adjuvant Chemotherapy in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma. In Vivo (IF 2.3) Pub Date : 2024-2-29 Itaru Hashimoto, Kazuki Kano, Hideaki Suematsu, Takanobu Yamada, Hayato Watanabe, Kyohei Kanematsu, Shinsuke Nagasawa, Toru Aoyama, Takashi Ogata, Yasushi Rino, Aya Saito, Takashi Oshima
Radical resection after preoperative adjuvant chemotherapy (NAC) is a standard treatment for patients with locally advanced esophageal squamous cell carcinoma (LAESCC), but its outcome remains unsatisfactory. In order to develop a personalized treatment program for LAES, we herein compared the survival prediction utility of five pre-NAC nutritional, inflammatory, and immune indexes in patients with
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Photodynamic Therapy With Resveratrol and an Nd:YAG Laser for Enterococcus faecalis Elimination. In Vivo (IF 2.3) Pub Date : 2024-2-29 Masaki Morikawa, Shunsuke Uehara, Akihiro Yoshida, Hiroshi Sakagami, Yoshiko Masuda
Enterococcus faecalis is the leading cause of endodontic treatment failures. Despite various conventional disinfection approaches, microorganisms often persist in root canals. Photodynamic therapy (PDT) is an adjunct antimicrobial strategy employing a nontoxic photosensitizer (PS) and light source. This study evaluated the antimicrobial effect of PDT using an Nd:YAG laser and resveratrol (RSV) with
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Effect of Jaw Tracking During Volumetric Modulated Arc Therapy for Facial Non-melanoma Skin Cancer. In Vivo (IF 2.3) Pub Date : 2024-2-29 So Hyun Park, Hyunsoo Ko, Jinhyun Choi
This study aimed to analyze the dosimetric effects of jaw tracking during Volumetric Modulated Arc Therapy (VMAT) planning for facial non-melanoma skin cancer (NMSC).
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Association Between AIRE Polymorphisms rs870881(C>T), rs1003854(T>C) and Rheumatoid Arthritis Risk: A Hungarian Case-control Study. In Vivo (IF 2.3) Pub Date : 2024-2-29 Balint Berczi, Nóra Nusser, Ivan Peter, Balazs Nemeth, Zoltan Gyongyi
Autoimmune regulator (AIRE) is a transcription factor that plays pivotal role in controlling autoimmunity. In the thymus, it supports the presentation of peripheral tissue antigens to developing T cells, where recognition of these self-antigens negatively selects the autoimmune naïve T-cells by central tolerance. Studies demonstrated that single-nucleotide polymorphisms (SNPs) in AIRE alter transcription
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Immunohistochemical Expression and Prognostic Value of COX-2 and Alpha-Smooth Muscle Actin-positive Cancer-associated Fibroblasts in Feline Mammary Cancer. In Vivo (IF 2.3) Pub Date : 2024-2-29 Jaynne C M Guimarães, Gonçalo Petrucci, Justina Prada, Isabel Pires, Felisbina L Queiroga
Cyclo-oxygenase-2 (COX-2) and cancer associated fibroblasts (CAFs) play an important role in the development and progression of tumor malignancy in humans and animals, showing that both can influence the tumor microenvironment. However, the impact of these two markers in feline mammary carcinogenesis has not yet been addressed.
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Severe Burn Injuries - The Day the Sodium Starts Rising. In Vivo (IF 2.3) Pub Date : 2024-2-29 Maximilian M Menger, Holger Wenz, Maximilian Bamberg, Sabrina KRAUß, Henrik Lauer, Tim Viergutz, Johann Fontana
The current study was designed to evaluate the etiologies of hypernatremic episodes in patients with severe burn injuries in comparison to critically ill non-burn patients.
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The Impact of PM2.5 on Radiation-induced Pneumonitis in Patients With Breast Cancer. In Vivo (IF 2.3) Pub Date : 2024-2-29 Dong-Yun Kim, In Ah Kim, Bum-Sup Jang
Exposure to particulate matter (PM) air pollution is known to adversely affect respiratory disease, but no study has examined its effect on radiation-induced pneumonitis (RIP) in patients with breast cancer.
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Exosome Secretion and Cellular Signaling Change in a Fabry Disease Cell Model Induced by Gene-silencing. In Vivo (IF 2.3) Pub Date : 2024-2-29 Sang Hyun Park, Dae Han Lee, Soon Ae Kim
Fabry disease (FD) is caused by α-galactosidase A (AGA) deficiency, which ultimately leads to the intracellular accumulation of globotriaosylceramide (Gb3). Exosomes play a role in maintaining cellular homeostasis by clearing damaged or toxic materials, including proteins. In the process of excessive accumulation of intracellular Gb3 in Fabry disease, it may be suggested that exosomal secretion of
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The Effect of Galantamine on Lipopolysaccharide-induced Acute Lung Injury During Neutropenia Recovery in Mice. In Vivo (IF 2.3) Pub Date : 2024-2-29 Oh Beom Kwon, Wan Seo, Kyu Yean Kim, Hyonsoo Joo, Chang Dong Yeo, Jin Woo Kim
Acute lung injury (ALI) is associated with a high mortality rate and cancer patients who receive chemotherapy are at high risk of ALI during neutropenia recovery. Galantamine is a cholinesterase inhibitor used for Alzheimer's disease treatment. Previous studies have shown that galantamine reduced inflammatory response in lipopolysaccharide (LPS)-induced ALI in rats. Mer protein was negatively associated