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Suturing Skills for Medical Students: A Systematic Review. In Vivo (IF 1.541) Pub Date : 2021-1-7 Thanos Emmanuel; Marios Nicolaides; Iakovos Theodoulou; Wai Yoong; Nikolaos Lymperopoulos; Michail Sideris
This systematic review aimed to identify all published evidence on teaching suturing skills for medical students. We aimed to outline significant positive teaching outcomes and devise a comprehensive framework for the optimal teaching of suturing skills for medical students.
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Therapeutic Application of Mesenchymal Stem Cells for Cochlear Regeneration. In Vivo (IF 1.541) Pub Date : 2021-1-7 Nagarajan Maharajan; Gwang Won Cho; Chul Ho Jang
Hearing loss is one of the major worldwide health problems that seriously affects human social and cognitive development. In the auditory system, three components outer ear, middle ear and inner ear are essential for the hearing mechanism. In the inner ear, sensory hair cells and ganglion neuronal cells are the essential supporters for hearing mechanism. Damage to these cells can be caused by long-term
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Sensitivity, Specificity and the Diagnostic Accuracy of PET/CT for Axillary Staging in Patients With Stage I-III Cancer: A Systematic Review of The Literature. In Vivo (IF 1.541) Pub Date : 2021-1-7 Judi Kasem; Umar Wazir; Kefah Mokbel
Axillary lymph node (ALN) status plays a key role in the staging of breast cancer. Positron Emission Tomography/Computed Tomography (PET/CT) using 18-Fluorodeoxyglucose (18FDG) can visualise ALN metastasis. However, its utility compared to current methods is unclear. We systematically reviewed the role of 18FDG PET/CT in breast cancer staging.
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Circulating Tumor Cells, Circulating Tumor DNA and Other Blood-based Prognostic Scores in Pancreatic Ductal Adenocarcinoma - Mini-Review. In Vivo (IF 1.541) Pub Date : 2021-1-7 Marian Liberko; Katarina Kolostova; Arpad Szabo; Robert Gurlich; Martin Oliverius; Renata Soumarova
Pancreatic ductal adenocarcinoma represents a disease with increasing incidence. Its prognosis is the worst among all malignancies despite the aggressive combined multimodal treatment across all stages. In metastatic disease, median survival is approximatelly one year. The mainstay of treatment is chemotherapy (neo/adjuvant, palliative) and in selected subgroups of patients even radiotherapy. Nevertheless
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Aortitis - An Interdisciplinary Challenge. In Vivo (IF 1.541) Pub Date : 2021-1-7 Tetyana Shchetysnka-Marinova; Klaus Amendt; Maliha Sadick; Michael Keese; Martin Sigl
The term 'aortitis' comprises a heterogeneous spectrum of diseases, with varied etiology and clinical presentations, whose common characteristic is the inflammation of the aortic wall. Since aortitis can mimic almost all common cardiovascular disorders, its clinical recognition remains a challenge. Some cases of aortitis remain undetected for a long time and may be diagnosed after severe life-threatening
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The Role of Nutritional Support in Malnourished Patients With Lung Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Agata Kasprzyk; Krzysztof Bilmin; Tomira Chmielewska-Ignatowicz; Jakub Pawlikowski; Urszula Religioni; Piotr Merks
This review aimed to aggregate and describe the available data about clinical nutrition in lung cancer and the role of the dietitian in multidisciplinary patient care. Scientific literature was searched in order to summarize key aspects related to clinical nutrition in lung cancer. This information can be used to arrange a proper nutritional therapy that can enhance patient treatment responses, prevent
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PCSK9 Antibody-based Treatment Strategies for Patients With Statin Intolerance. In Vivo (IF 1.541) Pub Date : 2021-1-7 Errika Voutyritsa; Christos Damaskos; Paraskevi Farmaki; Georgios Kyriakos; Evangelos Diamantis; Lourdes Victoria Quiles-SÁnchez; Anna Garmpi; Nikolaos Garmpis; Alexandros Patsouras; Athanasia Stelianidi; Spyridon Savvanis
Statin intolerance refers to the inability of a patient to tolerate statin therapy, presenting muscle aches, pains, weakness and muscle inflammation. Thus, numerous patients are not treated with suitable statin-based therapy or take only very low doses. As a result, the desired decrease in low-density lipoprotein cholesterol (LDL-C) is not achieved, resulting in patients at a high risk for cardiovascular
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An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma). In Vivo (IF 1.541) Pub Date : 2021-1-7 Shizuhide Nakayama; Jun Nishio; Mikiko Aoki; Kazuki Nabeshima; Takuaki Yamamoto
Desmoplastic fibroblastoma (also known as collagenous fibroma) is an uncommon benign fibroblastic/myofibroblastic neoplasm that primarily arises in the subcutaneous tissue of upper extremity. Magnetic resonance imaging reveals a well-defined mass in intimate association with dense connective tissue and prominent low signal intensity on all pulse sequences. Peripheral and septal enhancement is usually
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Contemporary Molecular Classification of Urinary Bladder Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Dimitrios Goutas; Andrianos Tzortzis; Harikleia Gakiopoulou; Dimitrios Vlachodimitropoulos; Ioanna Giannopoulou; Andreas C Lazaris
The significant heterogeneity in the clinical outcome among patients with bladder cancer has highlighted the existence of different biological subtypes of muscle-invasive and non-muscle-invasive bladder cancer. Transcriptional profiling studies revealed that primary bladder cancers can be grouped into 'intrinsic' basal and luminal molecular subtypes. Luminal tumors have a papillary configuration and
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Inflammatory Fibroid Polyp of the Gastrointestinal Tract: A Systematic Review for a Benign Tumor. In Vivo (IF 1.541) Pub Date : 2021-1-7 Nikolaos Garmpis; Christos Damaskos; Anna Garmpi; Vasiliki E Georgakopoulou; Stratigoula Sakellariou; Aliki Liakea; Dimitrios Schizas; Evangelos Diamantis; Paraskevi Farmaki; Errika Voutyritsa; Athanasios Syllaios; Alexandros Patsouras; Georgia Sypsa; Alexandra Agorogianni; Athanasia Stelianidi; Efstathios A Antoniou; Konstantinos Kontzoglou; Nikolaos Trakas; Dimitrios Dimitroulis
Inflammatory fibroid polyp (IFP) is a rare, usually solitary and intraluminal polypoid benign tumor that can affect any part of the gastrointestinal (GI) tract, although in the majority of cases it affects the stomach. This lesion is characterized by proliferation of highly vascular fibrous tissue and infiltration by a variable number of different inflammatory cells. Its etiology is unknown. Our aim
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The Angiotensin-converting Enzyme Insertion/Deletion Polymorphism as a Common Risk Factor for Major Pregnancy Complications. In Vivo (IF 1.541) Pub Date : 2021-1-7 Iphigenia Gintoni; Maria Adamopoulou; Christos Yapijakis
Idiopathic pregnancy complications pose a major threat to both maternal and fetal health worldwide. Numerous studies have implicated the role of the renin-angiotensin system (RAS) in the development of obstetric syndromes, since it is crucial for the uteroplacental function. A major RAS component is the angiotensin-converting enzyme (ACE), which hydrolyses angiotensin I to angiotensin II, and not only
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A Novel Procedure for Orthotopic Tibia Implantation for Establishment of a More Clinical Osteosarcoma PDOX Mouse Model. In Vivo (IF 1.541) Pub Date : 2021-1-7 Nathaniel F Wu; Jun Yamamoto; Michael Bouvet; Robert M Hoffman
Osteosarcoma is a rare type of malignancy that affects mostly children and adolescents. A new procedure was designed to create an improved patient-derived orthotopic xenograft (PDOX) mouse model of osteosarcoma that more closely mimics osteosarcoma in clinical settings. Previous osteosarcoma PDOX models involved implanting a tumor fragment near the femur of nude mice in a space created by separating
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In Vivo Evaluation of Combined CK2 Inhibition and Irradiation in Human WiDr Tumours. In Vivo (IF 1.541) Pub Date : 2021-1-7 Felix Zwicker; Henrik Hauswald; Klaus-Josef Weber; JÜrgen Debus; Peter E Huber
Casein kinase 2 (CK2) which sustains multiple pro-survival functions in cellular DNA-damage response, is strictly regulated in normal cells but elevated in cancer. CK2 is considered as a potential therapeutic target, and its inhibition has been associated with radiosensitization in mammalian cells in vitro. Here, we investigated potential radiosensitization by CK2 inhibition in vivo.
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Inhibition of Colony-Stimulating Factor-1 Receptor Enhances the Efficacy of Radiotherapy and Reduces Immune Suppression in Glioblastoma. In Vivo (IF 1.541) Pub Date : 2021-1-7 Muayad F Almahariq; Thomas J Quinn; Pravin Kesarwani; Shiva Kant; C Ryan Miller; Prakash Chinnaiyan
To use inhibition of colony-stimulating factor-1 receptor (CSF-1R) to target tumor-associated macrophages (TAMs) and improve the efficacy of radiotherapy in glioblastoma (GBM).
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Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Seongsik Bang; Seungyun Jee; Hyunsung Kim; Kiseok Jang; Hosub Park; Jae Kyung Myung; Dongho Choi; Su-Jin Shin; Seung Sam Paik
Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples.
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Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors. In Vivo (IF 1.541) Pub Date : 2021-1-7 Jaclyn Lopiccolo; Shigeru Kawabata; Joell J Gills; Phillip A Dennis
Nelfinavir is a human immunodeficiency virus protease inhibitor that is currently being repositioned as an anticancer drug. Chloroquine, an anti-malarial lysosomotropic drug, inhibits autophagy. It has been reported that the combination of nelfinavir and chloroquine significantly enhances endoplasmic reticulum (ER) stress and induces selective cell death in multiple cell line models (in vitro).
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PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes. In Vivo (IF 1.541) Pub Date : 2021-1-7 Masamichi Nakata; Michiko Shimada; Ikuyo Narita-Kinjo; Daiki Nagawa; Kazutaka Kitayama; Misato Hamadate; Naotake Miura; Masashi Nozaka; Yosuke Kawamura; Takeshi Fujita; Reiichi Murakami; Tadaatsu Imaizumi; Norio Nakamura; Hirofumi Tomita
Viral infection often exacerbates proteinuria, which has been suggested to be due to antiviral responses of podocytes. We examined the effect of polyinosinic-polycytidylic acid (polyIC) on the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) in differentiated human podocytes in culture.
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Protective Effects of Baicalin on Arsenic Trioxide-induced Oxidative Damage and Apoptosis in Human Umbilical Vein Endothelial Cells. In Vivo (IF 1.541) Pub Date : 2021-1-7 Chung-Lin Tsai; Chia-Wen Tsai; Wen-Shin Chang; Jiunn-Cherng Lin; Te-Chun Hsia; DA-Tian Bau
Arsenic trioxide (As2O3) is an environmental pollutant. However, the detailed mechanisms about As2O3-induced loss of endothelial integrity are unknown. This study aimed at investigating how As2O3 causes endothelial dysfunction and whether baicalin can reverse such dysfunction.
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NR6A1 Allelic Frequencies as an Index for both Miniaturizing and Increasing Pig Body Size. In Vivo (IF 1.541) Pub Date : 2021-1-7 Moe Ijiri; Yu-Chang Lai; Hiroaki Kawaguchi; Yoshikazu Fujimoto; Naoki Miura; Tomohide Matsuo; Akihide Tanimoto
The number of vertebrae in swine varies from 19 to 23 and is associated with body size. Nuclear receptor subfamily 6 group A member 1 (NR6A1) is considered a strong candidate for affecting the number of vertebrae in swine. Wild boars, which uniformly have 19 vertebrae, have the wild type allele while multi-vertebrae European commercial pigs have the mutated allele. Our aim was to confirm the factor
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Correlation Between Onco-suppressors PTEN and NM23 and Clinical Outcome in Patients With T1 Breast Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Luciano Izzo; Daniela Messineo; Pierfrancesco DI Cello; Virgilio Nicolanti; Antonio Sterpetti; Sara Izzo; Paolo Izzo
The aim of the present work was to evaluate the prognostic significance in patients with T1 breast cancer of tissue expression of the two oncosuppressors phosphatase and tensin homolog (PTEN) and non-metastatic clone 23 (NM23) as detected by immunohistochemistry.
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Effects of GGsTop® on Collagen and Glutathione in the Oral Mucosa Using a Rat Model of 5-Fluorouracil-Induced Oral Mucositis. In Vivo (IF 1.541) Pub Date : 2021-1-7 Issei Takeuchi; Riko Kawamata; Kimiko Makino
To evaluate the usefulness of GGsTop® for oral mucositis, a quantitative study focusing on oral mucosal tissues is necessary. In this study, we aimed to quantify collagen and glutathione using a rat model of 5-fluorouracil-induced oral mucositis.
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Mitochondrial DNA Methylation Is Higher in Acute Coronary Syndrome Than in Stable Coronary Artery Disease. In Vivo (IF 1.541) Pub Date : 2021-1-7 Sang Hyun Park; Soo Young Lee; Soon Ae Kim
Decreased mitochondrial DNA copy number (mtDNA-CN) has been associated with coronary artery disease (CAD). We aimed to clarify the difference between stable CAD (SCAD) and acute coronary syndrome (ACS) regarding mtDNA-CN and the DNA methylation ratio in regions influencing the regulation of mitochondrial biogenesis.
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ELF3 Overexpression as Prognostic Biomarker for Recurrence of Stage II Colorectal Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Ayumi Takaoka; Toshiaki Ishikawa; Satoshi Okazaki; Shuichi Watanabe; Fuyuki Miya; Tatsuhiko Tsunoda; Akifumi Kikuchi; Shinichi Yamauchi; Takatoshi Matsuyama; Masanori Tokunaga; Hiroyuki Uetake; Yusuke Kinugasa
Adjuvant chemotherapy for high-risk Stage II colorectal cancer (CRC) is weakly recommended; however, no consensus exists on "high-risk" definition. Prognostic biomarker identification is important for selecting patients with poor prognosis who may benefit from adjuvant chemotherapy.
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MYC Up-regulation Is a Useful Biomarker for Preoperative Neoadjuvant Chemotherapy Combined With Anti-EGFR in Liver Metastasis from Colorectal Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Takazumi Kato; Nobuhisa Matsuhashi; Hiroyuki Tomita; Takao Takahashi; Yoshinori Iwata; Masahiro Fukada; Itaru Yasufuku; Tomonari Suetsugu; Takeharu Imai; Ryutaro Mori; Hisashi Imai; Yoshihiro Tanaka; Naoki Okumura; Akira Hara; Kazuhiro Yoshida
At present, there are no biomarkers to predict the effects of molecular targeted drugs in patients with CRC with liver metastasis. Thus, we performed this study to explore potential biomarkers for these patients.
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Anti-metastatic Effects of Cationic KT2 Peptide (a Lysine/Tryptophan-rich Peptide) on Human Melanoma A375.S2 Cells. In Vivo (IF 1.541) Pub Date : 2021-1-7 Pornsuda Maraming; Sompong Klaynongsruang; Patcharee Boonsiri; Shu-Fen Peng; Sakda Daduang; Prapenpuksiri Rungsa; Ratree Tavichakorntrakool; Jing-Gung Chung; Jureerut Daduang
KT2 is a lysine/tryptophan-rich peptide modified from Crocodylus siamensis Leucrocin I. In this study, we examined the cell toxicity, cellular uptake, anti-migration and anti-invasion activities of KT2 in A375.S2 human melanoma cells.
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Sulfite Oxidase Is a Novel Prognostic Biomarker of Advanced Gastric Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Yuta Yano; Jun Akiba; Yoshiki Naito; Eiji Sadashima; Haruhiko Cho; Tsunekazu Hishima; Hirohisa Yano
Sulfite oxidase (SUOX) is an enzyme present in the mitochondria, which has been demonstrated to be correlated with various malignant tumours.
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Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion In Vivo. In Vivo (IF 1.541) Pub Date : 2021-1-7 Hironobu Yanagie; Takashi Fujino; Masashi Yanagawa; Toshimitsu Terao; Takashi Imagawa; Mitsuteru Fujihara; Yasuyuki Morishita; Ryouji Mizumachi; Yuuji Murata; Novriana Dewi; Yuuya Ono; Ichiro Ikushima; Koji Seguchi; Masashi Nagata; Yasumasa Nonaka; Yoshitaka Furuya; Tomoyuki Hisa; Takeshi Nagasaki; Kazuhiko Arimori; Tadao Nakashima; Takumichi Sugihara; Kazuhiro Kakimi; Minoru Ono; Jun Nakajima; Masazumi
A mixture of anticancer agents and iodized poppy seed oil (IPSO) has been widely used for intra-arterial chemotherapy of hepatocellular carcinoma. However, the anticancer agents can easily separate from IPSO, so the therapeutic potential is limited. We developed epirubicin-entrapped water-in-oil-in-water emulsion (WOW-Epi) using a double-membrane emulsification technique.
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Curcumin Activates ROS Signaling to Promote Pyroptosis in Hepatocellular Carcinoma HepG2 Cells. In Vivo (IF 1.541) Pub Date : 2021-1-7 Wan-Feng Liang; Yi-Xi Gong; Hai-Feng Li; Fu-Liang Sun; Wei-Long Li; Dong-Qin Chen; Dan-Ping Xie; Chen-Xi Ren; Xiao-Yu Guo; Zi-Yi Wang; Taeho Kwon; Hu-Nan Sun
Curcumin is a polyphenol that exerts a variety of pharmacological activities and plays an anti-cancer role in many cancer cells. It was recently reported that gasdermin E (GSDME) is involved in the progression of pyroptosis.
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Changes in the Mineral Composition of Rat Tissues Induced by Breast Cancer and Dietary Supplementation. In Vivo (IF 1.541) Pub Date : 2021-1-7 Dorota Skrajnowska; Andrzej Tokarz; Justyna Makowska; Barbara Bobrowska-Korczak
The aim of the study was to determine the effect of various diets with zinc or zinc in combination with resveratrol or genistein on mineral contents of the serum, urine, liver, kidney and heart in rats with chemically-induced mammary carcinoma.
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Aberrant GLUT1 Expression Is Associated With Carcinogenesis and Progression of Liver Fluke-associated Cholangiocarcinoma. In Vivo (IF 1.541) Pub Date : 2021-1-7 Ubonrat Thamrongwaranggoon; Sakkarn Sangkhamanon; Wunchana Seubwai; Paksiree Saranaruk; Ubon Cha'on; Sopit Wongkham
Glucose transporter 1 (GLUT1) has been demonstrated to be overexpressed in various cancer tissues and play a significant role on growth, metastasis, and apoptosis in cancer cells. This study aimed to reveal the clinical relevance of glucose transporter 1 (GLUT1) in carcinogenesis and progression on liver fluke-associated cholangiocarcinoma (CCA).
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Deformation of the Pelvic Arteries Caused by Pneumoperitoneum and Postural Changes in an Animal Model. In Vivo (IF 1.541) Pub Date : 2021-1-7 Hidemichi Kiyomatsu; Lei Ma; Junchen Wang; Tomomichi Kiyomatsu; Hiroyuki Tsukihara; Etsuko Kobayashi; Ichiro Sakuma; Souichiro Ishihara
We investigated pelvic arterial deformation and shift due to intraoperative pneumoperitoneum and postural changes in an animal model.
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Effects of Different Media on Human T Regulatory Cells Phenotype. In Vivo (IF 1.541) Pub Date : 2021-1-7 Magdalena GŁaczynska; Maja Machcinska; Katarzyna Donskow-Lysoniewska
Functional and quantitative Treg cell defects have been identified in a variety of autoimmune diseases. Therefore, Tregs are a major pharmaceutical target for these disorders. In the last decades, studies have been mainly focused on the identification and experimental understanding of the activity of Tregs and their mechanisms of action.
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Relationship Between Insulin-Receptor Substrate 1 and Langerhans' Islet in a Rat Model of Type 2 Diabetes Mellitus. In Vivo (IF 1.541) Pub Date : 2021-1-7 Wahyuni Lukita Atmodjo; Young Othiwi Larasati; Juandy Jo; Riska Nufika; Steffi Naomi; Imelda Winoto
In vivo studies on pathogenesis of type 2 diabetes mellitus (T2DM) have been reported, however, the relationship between insulin-receptor substrate 1 (IRS1) and the area of Langerhans' islets was unknown. Therefore, a correlation between both parameters was assessed.
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High MCM6 Expression as a Potential Prognostic Marker in Clear-cell Renal Cell Carcinoma. In Vivo (IF 1.541) Pub Date : 2021-1-7 Nu-Ri Jang; Jina Baek; Younghwii Ko; Phil Hyun Song; Mi-Jin Gu
Minichromosome maintenance (MCM) proteins are involved in initiation of DNA replication and cell-cycle progression. Loss of MCM function results in genomic instability and causes carcinogenesis. Among MCM genes, the role and prognostic value of MCM6 expression in clear-cell renal cell carcinoma (ccRCC) has not been elucidated.
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IGF-1 Protects Neurons in the Cortex and Subventricular Zone in a Periventricular Leucomalacia Model. In Vivo (IF 1.541) Pub Date : 2021-1-7 Dong-Joon Kim; Su-Yeon Cho; Seung-Un Kim; Dong-Won Jo; Hyo-In Hwang; Hye-Kyoung Shin; Yong-Hyun Jun
Chronic cerebral hypoperfusion affects early and mature neurons in the subventricular zone (SVZ) and cerebral cortex. Herein, we investigated the effects of insulin-like growth factor-1 (IGF-1), a neurogenesis-promoting agent, on neurons in these regions in periventricular leucomalacia (PVL) model rats.
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Enamel Matrix Derivative in Diffusion Chamber Implanted Subcutaneously in Rat Induces Formation of Fibrous Connective Tissue Containing Abundant Blood Vessels. In Vivo (IF 1.541) Pub Date : 2021-1-7 Satoshi Yokose; Yuka Kato; Katsutoshi Matsumoto; Perry R Klokkevold; Henry H Takei; Hiroshi Kawazu; Hiroshi Sakagami
Enamel matrix derivative (EMD) is widely used for regeneration therapy in dental clinical situations, but the mechanism of EMD bioactivity remains obscure. To clarify this mechanism, we focused on the formation of connective tissue and blood vessels. The aim of this study was to confirm whether EMD induces the formation of connective tissue and blood vessels by using the diffusion chamber (DC) technique
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MicroRNA Deregulation in Papillary Thyroid Cancer and its Relationship With BRAF V600E Mutation. In Vivo (IF 1.541) Pub Date : 2021-1-7 Petr Celakovsky; Helena Kovarikova; Viktor Chrobok; Jan Mejzlik; Jan Laco; Hana Vosmikova; Marcela Chmelarova; Ales Ryska
MicroRNAs (miRNAs) are non-coding regulatory molecules 18-25 nucleotides in length that act as post-transcriptional regulators of gene expression. MiRNAs affect various biological processes including carcinogenesis. Deregulation of miRNAa expression has been described in a variety of tumors including papillary thyroid carcinoma (PTC). The aim of the present study was to investigate the role of selected
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Culture Separation, Identification and Unique Anti-pathogenic Fungi Capacity of Endophytic Fungi from Gucheng Salvia Miltiorrhiza. In Vivo (IF 1.541) Pub Date : 2021-1-7 Guo-Kai Wang; Jai-Sing Yang; Yu-Fei Huang; Jin-Song Liu; Chia-Wen Tsai; DA-Tian Bau; Wen-Shin Chang
Salvia miltiorrhiza is a medical herb for human disorders including cardiovascular diseases and cancer. However, the interactions between Salvia miltiorrhiza and its endophytes are largely unknown. The current study aimed at identifying its endophytic fungi and examining their inhibitory effects on anti-pathogenic fungus.
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Expression of Syndecan-1 in Chronic Liver Diseases: Correlation With Hepatic Fibrosis. In Vivo (IF 1.541) Pub Date : 2021-1-7 Antonia Charchanti; Panagiotis Kanavaros; Efthymios Koniaris; Agapi Kataki; Georgios Glantzounis; Niki J Agnantis; Anna C Goussia
The mechanisms underlying the contribution of the heparan sulfate proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as fibrogenesis, remain to be elucidated. Therefore, we investigated the immunohistochemical expression of syndecan-1 in chronic liver diseases (CLDs) and its probable role in hepatic fibrosis.
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Metabolic-targeted Combination Therapy With Dichloroacetate and Metformin Suppresses Glioblastoma Cell Line Growth In Vitro and In Vivo. In Vivo (IF 1.541) Pub Date : 2021-1-7 Laura Korsakova; Jan Aleksander Krasko; Edgaras Stankevicius
We investigated the hypothesis that dichloroacetate (DCA), a pyruvate dehydrogenase kinase inhibitor, and metformin (MET), an antidiabetic agent and complex I inhibitor, have synergistic cytotoxic effects in glioblastoma cells in vitro and in vivo.
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Sphenoid Bone Pneumatisation on Lateral Cephalograms of Patients With Neurofibromatosis Type 1. In Vivo (IF 1.541) Pub Date : 2021-1-7 Reinhard E Friedrich; Hannah T Scheuer; Jan F Kersten; Hanna A Scheuer
Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease that causes tumors and many developmental disorders, e.g., cranial dysplasia. The purpose of this retrospective study was to analyse the pneumatisation of the sphenoid bone in NF1.
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Predictors for Grip Strength Loss in Patients With Chronic Liver Diseases. In Vivo (IF 1.541) Pub Date : 2021-1-7 Hiroki Nishikawa; Kazunori Yoh; Hirayuki Enomoto; Naoto Ikeda; Tomoyuki Takashima; Nobuhiro Aizawa; Takashi Nishimura; Shuhei Nishiguchi; Hiroko Iijima
To elucidate factors associated with secular changes of grip strength (GS) in patients with chronic liver diseases (CLDs) (n=241, 102 males, median age=63 years, 87 liver cirrhosis cases).
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Prognostic Factors in Hormone-sensitive Prostate Cancer Patients Treated With Combined Androgen Blockade: A Consecutive 15-year Study at a Single Japanese Institute. In Vivo (IF 1.541) Pub Date : 2021-1-7 Yoshiyuki Miyazawa; Yoshitaka Sekine; Seiji Arai; Daisuke Oka; Hiroshi Nakayama; Takahiro Syuto; Masashi Nomura; Hidekazu Koike; Hiroshi Matsui; Yasuhiro Shibata; Kazuhiro Suzuki
There are several treatment options for metastatic hormone-sensitive prostate cancer (mHSPC) in the world. In recent years, the use of docetaxel, abiraterone, enzalutamide, and apalutamide has been used for mHSPC, but combined androgen blockade (CAB) therapy using first-generation antiandrogens has been widely used in Japan. There is a background. We performed a consecutive study of patients who received
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Adolescents and Young Adults (AYAs) With Initially Localized and Metastatic Bone Sarcomas: A Retrospective Single Center Analysis of Side Effect Management. In Vivo (IF 1.541) Pub Date : 2021-1-7 Christoph Minichsdorfer; Oskar Steinbrecher; Marita KÖlz; Maximilian Schmid; Markus Raderer; Thomas Brodowicz; Wolfgang Lamm
Ewing sarcoma (ES) and osteosarcomas (OSA) are the most common bone tumor types in adolescents and young adults (AYA). Therapy management of these tumors consists of preoperative chemotherapy, operation, and postoperative chemotherapy. The aim of this study was to evaluate the efficacy and tolerability of EURAMOS-A and EURO E.W.I.N.G. protocols.
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The Epidemiology, Staging and Outcomes of Sarcomatoid Hepatocellular Carcinoma: A SEER Population Analysis. In Vivo (IF 1.541) Pub Date : 2021-1-7 Dimitrios Giannis; Sara Morsy; Georgios Geropoulos; Stepan M Esagian; Georgios S Sioutas; Dimitrios Moris
Hepatocellular carcinoma (HCC) subtypes differ in terms of histopathology and prognosis. Sarcomatoid HCC is rare and literature concerning the survival of patients with sarcomatoid HCC is scarce.
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Sarcopenia may Influence the Prognosis in Advanced Thyroid Cancer Patients Treated With Molecular Targeted Therapy. In Vivo (IF 1.541) Pub Date : 2021-1-7 Akihiro Nishiyama; Yukiko Staub; Yukio Suga; Mikiya Fujita; Azusa Tanimoto; Koushiro Ohtsubo; Seiji Yano
Reportedly, sarcopenia and nutritional status are associated with prognosis in cancer patients. However, data regarding the relationship of these factors with advanced thyroid cancer patients receiving molecular targeted therapy remains scarce. Therefore, we investigated the relationship between nutritional assessment, as well as sarcopenia, and prognosis in patients with advanced thyroid cancer undergoing
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Comparison of Conventional Fractionation and Accelerated Fractionation With Concomitant Boost for Radiotherapy of Non-metastatic Stage IV Head-and-Neck Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Carlos Narvaez; Steven E Schild; Dirk Rades
Some patients with unresectable or incompletely resected head-and-neck cancer (SCCHN) cannot tolerate radiochemotherapy. Alternatives are needed that are more effective than conventional radiotherapy alone.
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Prognostic Factors After Surgical Treatment of Liver Metastases from Breast Cancer - 19 Years of Experience. In Vivo (IF 1.541) Pub Date : 2021-1-7 KristÝna ProchÁzkovÁ; KristÝna PivovarČÍkovÁ; Milena RouŠarovÁ; Josef VodiČka; Petr HoŠek; Inka TŘeŠkovÁ; OndŘej Hes; Radek KuČera; OndŘej TopolČan; Vladislav TŘeŠka
The aim of this study was to determine the importance of surgical treatment, utility of hormone receptor status and selected biomarkers in the prognosis of patients with liver metastases from breast cancer (BCLM).
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A Comparative Study of Pigmented and Non-pigmented Basal Cell Carcinoma in Reflectance Confocal Microscopy. In Vivo (IF 1.541) Pub Date : 2021-1-7 Anna Pogorzelska-Antkowiak; SŁawomir Grzegorczyn; Paola Corneli; Jacek C Szepietowski
Basal cell carcinoma (BCC) is a common skin cancer, especially in the elderly population. The probability of BCC development increases past the age of 55. Dermoscopy and reflectance confocal microscopy (RCM) are two modern tools useful in the diagnosis of BCC.
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Evaluation of Sodium (23Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer's Disease. In Vivo (IF 1.541) Pub Date : 2021-1-7 Sherif A Mohamed; Katrin Herrmann; Anne Adlung; Nadia Paschke; Lucrezia Hausner; Lutz FrÖlich; Lothar Schad; Christoph Groden; Hans Ulrich Kerl
Sodium (23Na) MR imaging is a noninvasive MRI technique that has been shown to be sensitive to visualize biochemical information about tissue viability, their cell integrity, and cell function in various studies. The aim of this study was to evaluate differences in regional brain 23Na signal intensity between Alzheimer's disease (AD) and healthy controls to preliminarily evaluate the capability of
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CD133 Expression Predicts Relapse in Patients With Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemotherapy. In Vivo (IF 1.541) Pub Date : 2021-1-7 Haruka Oi; Takashi Okuyama; Shunya Miyazaki; Yuko Ono; Masatoshi Oya
The aim of the present study was to explore the association between CD133 expression and postoperative relapses in patients with locally advanced rectal cancer (LARC) who received neoadjuvant chemotherapy (NAC).
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Dosimetric Comparison Between Carbon-ion Radiotherapy and Photon Radiotherapy for Stage I Esophageal Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Yosuke Takakusagi; Daisaku Yoshida; Yohsuke Kusano; Kio Kano; Wataru Anno; Keisuke Tsuchida; Nobutaka Mizoguchi; Itsuko Serizawa; Hiroyuki Katoh; Koh Imura; Yoshiki Takayama; Shinichi Minohara; Tadashi Kamada
The present study aimed to compare the radiation dose distribution of carbon-ion radiotherapy (CIRT) for stage I esophageal cancer with three-dimensional conformal radiotherapy (3DCRT) and volumetric modulated arc therapy (VMAT).
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Micropapillary Bladder Cancer Metastatic to the Breast: A Case Report and Brief Literature Review. In Vivo (IF 1.541) Pub Date : 2021-1-7 Elena Lievore; Letterio Runza; Michele Ghidini; Barbara Galassi; Andrea Gallioli; Carolina Bebi; Luca Boeri; Concetta Blundo; Claudia Francesca Rossi; Fabrizio Longo; Giancarlo Albo; Emanuele Montanari; Elisa DE Lorenzis
Bladder cancer (BC) usually metastasizes to the lymph nodes, bone, lung, liver and peritoneum, but rarely in the breast.
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Radiation to the Primary Tumor in Metastatic Anaplastic Thyroid Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Teresa Augustin; Dmytro Oliinyk; Josefine Rauch; Viktoria Florentine Koehler; Christine Spitzweg; Claus Belka; Lukas KÄsmann
Metastatic anaplastic thyroid cancer is associated with a dismal prognosis. We evaluated outcome and prognostic factors in patients receiving radiation to the primary tumor in metastatic anaplastic thyroid cancer (ATC).
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Coexistence of Emphysema With Non-small-cell Lung Cancer Predicts the Therapeutic Efficacy of Immune Checkpoint Inhibitors. In Vivo (IF 1.541) Pub Date : 2021-1-7 Yusuke Takayama; Takashi Nakamura; Yuki Fukushiro; Shohei Mishima; Ken Masuda; Hiroyasu Shoda
Chronic obstructive pulmonary disease coexisting with non-small-cell lung cancer (NSCLC) was reported to be associated with a longer progression-free survival (PFS) in patients treated with immune checkpoint inhibitors (ICIs). In the present study, we investigated the impact of emphysematous change on the treatment response to ICIs in patients with NSCLC.
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Prognosis of Immune-related Adverse Events in Patients With Advanced Gastric Cancer Treated With Nivolumab or Pembrolizumab: A Multicenter Retrospective Analysis. In Vivo (IF 1.541) Pub Date : 2021-1-7 Takayuki Ando; Akira Ueda; Kohei Ogawa; Iori Motoo; Shinya Kajiura; Takahiko Nakajima; Katsuhisa Hirano; Tomoyuki Okumura; Kenichiro Tsukada; Takuo Hara; Nobuhiro Suzuki; Naokatsu Nakada; Naoki Horikawa; Tsutomu Fujii; Ichiro Yasuda
Immune-checkpoint inhibitors (ICI), including nivolumab and pembrolizumab, are among the standard treatments for previously treated advanced gastric cancer (AGC). This study aimed to evaluate the frequency of immune-related adverse events (irAEs) and the correlation between irAEs and their efficacy in AGC cases.
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Palliative Radiotherapy of Primary Glioblastoma. In Vivo (IF 1.541) Pub Date : 2021-1-7 Jaspar Witteler; Steven E Schild; Dirk Rades
Care is often palliative when patients are not fit and complete resection of glioblastomas cannot be achieved. This study aimed to identify predictors of survival after palliative radiotherapy.
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Tensor Regression-based Model to Investigate Heterogeneous Spatial Radiosensitivity After I-125 Seed Implantation for Prostate Cancer. In Vivo (IF 1.541) Pub Date : 2021-1-7 Kazuma Kobayashi; Naoya Murakami; Kana Takahashi; Koji Inaba; Hiroshi Igaki; Ryuji Hamamoto; Jun Itami
We established a data-driven method for extracting spatial patterns of dose distribution associated with radiation injuries, based on patients with prostate cancer who underwent iodine-125 (I-125) seed implantation.
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ATM Expression as a Prognostic Marker in Patients With Advanced Biliary Tract Cancer Treated With First-line Gemcitabine and Platinum Chemotherapy. In Vivo (IF 1.541) Pub Date : 2021-1-7 Hyera Kim; Seung Tae Kim; Kwai Han Yoo; Jung Yong Hong; Young Suk Park; Ho Yeong Lim; Joon Oh Park
Biliary tract cancer (BTC) has a poor prognosis due to its highly invasive and metastatic potential. Ataxia-telangiectasia mutated (ATM) is a key regulator of DNA damage response and an emerging therapeutic target; however, the association between the expression of ATM and the prognosis in advanced BTC is unknown. We aimed to identify the relationship between ATM expression, clinicopathological characteristics
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A Prognostic Score for Predicting Survival in Patients With Pancreatic Head Adenocarcinoma and Distal Cholangiocarcinoma. In Vivo (IF 1.541) Pub Date : 2021-1-7 Edoardo Maria Muttillo; Antonio Ciardi; Paolina Saullo; Raffaele Troiano; Gabriele Masselli; Marianna Guida; Alessandra Tortora; Isabella Sperduti; Giulio Marinello; Piero Chirletti; Roberto Caronna
Survival of patients with pancreatic cancer remains poor despite improvements in therapeutic strategies. This study aims to create a novel preoperative score to predict prognosis in patients with tumors of the pancreaticobiliary head.
更新日期:2021-01-09