样式: 排序: IF: - GO 导出 标记为已读
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ResDeepSurv: A Survival Model for Deep Neural Networks Based on Residual Blocks and Self-attention Mechanism Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-03-15 Yuchen Wang, Xianchun Kong, Xiao Bi, Lizhen Cui, Hong Yu, Hao Wu
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CHL-DTI: A Novel High–Low Order Information Convergence Framework for Effective Drug–Target Interaction Prediction Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-03-14 Shudong Wang, Yingye Liu, Yuanyuan Zhang, Kuijie Zhang, Xuanmo Song, Yu Zhang, Shanchen Pang
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SeFilter-DIA: Squeeze-and-Excitation Network for Filtering High-Confidence Peptides of Data-Independent Acquisition Proteomics Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-03-12
Abstract Mass spectrometry is crucial in proteomics analysis, particularly using Data Independent Acquisition (DIA) for reliable and reproducible mass spectrometry data acquisition, enabling broad mass-to-charge ratio coverage and high throughput. DIA-NN, a prominent deep learning software in DIA proteome analysis, generates peptide results but may include low-confidence peptides. Conventionally, biologists
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Identifying Protein Phosphorylation Site-Disease Associations Based on Multi-Similarity Fusion and Negative Sample Selection by Convolutional Neural Network Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-03-08 Qian Deng, Jing Zhang, Jie Liu, Yuqi Liu, Zong Dai, Xiaoyong Zou, Zhanchao Li
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GraphsformerCPI: Graph Transformer for Compound–Protein Interaction Prediction Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-03-08
Abstract Accurately predicting compound–protein interactions (CPI) is a critical task in computer-aided drug design. In recent years, the exponential growth of compound activity and biomedical data has highlighted the need for efficient and interpretable prediction approaches. In this study, we propose GraphsformerCPI, an end-to-end deep learning framework that improves prediction performance and interpretability
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Predicting Microbe-Disease Associations Based on a Linear Neighborhood Label Propagation Method with Multi-order Similarity Fusion Learning Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-03-04
Abstract Computational approaches employed for predicting potential microbe-disease associations often rely on similarity information between microbes and diseases. Therefore, it is important to obtain reliable similarity information by integrating multiple types of similarity information. However, existing similarity fusion methods do not consider multi-order fusion of similarity networks. To address
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Singular Value Decomposition-Driven Non-negative Matrix Factorization with Application to Identify the Association Patterns of Sarcoma Recurrence Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-03-01 Jin Deng, Kaijun Li, Wei Luo
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Machine Learning Accelerates De Novo Design of Antimicrobial Peptides Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-02-28 Kedong Yin, Wen Xu, Shiming Ren, Qingpeng Xu, Shaojie Zhang, Ruiling Zhang, Mengwan Jiang, Yuhong Zhang, Degang Xu, Ruifang Li
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Transformative Deep Neural Network Approaches in Kidney Ultrasound Segmentation: Empirical Validation with an Annotated Dataset Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-02-27 Rashid Khan, Chuda Xiao, Yang Liu, Jinyu Tian, Zhuo Chen, Liyilei Su, Dan Li, Haseeb Hassan, Haoyu Li, Weiguo Xie, Wen Zhong, Bingding Huang
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Predicting circRNA-RBP Binding Sites Using a Hybrid Deep Neural Network Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-02-21 Liwei Liu, Yixin Wei, Zhebin Tan, Qi Zhang, Jianqiang Sun, Qi Zhao
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A Review of the Application of Spatial Transcriptomics in Neuroscience Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-02-20 Le Zhang, Zhenqi Xiong, Ming Xiao
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scEM: A New Ensemble Framework for Predicting Cell Type Composition Based on scRNA-Seq Data Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-02-18 Xianxian Cai, Wei Zhang, Xiaoying Zheng, Yaxin Xu, Yuanyuan Li
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Inference of Gene Regulatory Networks Based on Multi-view Hierarchical Hypergraphs Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-02-11 Songyang Wu, Kui Jin, Mingjing Tang, Yuelong Xia, Wei Gao
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A Combined Manual Annotation and Deep-Learning Natural Language Processing Study on Accurate Entity Extraction in Hereditary Disease Related Biomedical Literature Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-02-10
Abstract We report a combined manual annotation and deep-learning natural language processing study to make accurate entity extraction in hereditary disease related biomedical literature. A total of 400 full articles were manually annotated based on published guidelines by experienced genetic interpreters at Beijing Genomics Institute (BGI). The performance of our manual annotations was assessed by
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Synchronous Mutual Learning Network and Asynchronous Multi-Scale Embedding Network for miRNA-Disease Association Prediction Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-02-04 Weicheng Sun, Ping Zhang, Weihan Zhang, Jinsheng Xu, Yanrong Huang, Li Li
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PDDGCN: A Parasitic Disease–Drug Association Predictor Based on Multi-view Fusion Graph Convolutional Network Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-01-31 Xiaosong Wang, Guojun Chen, Hang Hu, Min Zhang, Yuan Rao, Zhenyu Yue
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Predicting miRNA–Disease Associations by Combining Graph and Hypergraph Convolutional Network Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-01-29 Xujun Liang, Ming Guo, Longying Jiang, Ying Fu, Pengfei Zhang, Yongheng Chen
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LPI-SKMSC: Predicting LncRNA–Protein Interactions with Segmented k-mer Frequencies and Multi-space Clustering Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-01-11 Dian-Zheng Sun, Zhan-Li Sun, Mengya Liu, Shuang-Hao Yong
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PPSNO: A Feature-Rich SNO Sites Predictor by Stacking Ensemble Strategy from Protein Sequence-Derived Information Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-01-11 Lun Zhu, Liuyang Wang, Zexi Yang, Piao Xu, Sen Yang
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Protein Multiple Conformation Prediction Using Multi-Objective Evolution Algorithm Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-01-08 Minghua Hou, Sirong Jin, Xinyue Cui, Chunxiang Peng, Kailong Zhao, Le Song, Guijun Zhang
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A Deep Neural Network for Predicting Synergistic Drug Combinations on Cancer Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2024-01-06 Shiyu Yan, Ding Zheng
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Drug Repositioning Based on Deep Sparse Autoencoder and Drug–Disease Similarity Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-12-16
Abstract Drug repositioning is critical to drug development. Previous drug repositioning methods mainly constructed drug–disease heterogeneous networks to extract drug–disease features. However, these methods faced difficulty when we are using structurally simple models to deal with complex heterogeneous networks. Therefore, in this study, the researchers introduced a drug repositioning method named
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Hessian Regularized $$L_{2,1}$$ -Nonnegative Matrix Factorization and Deep Learning for miRNA–Disease Associations Prediction Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-12-15 Guo-Sheng Han, Qi Gao, Ling-Zhi Peng, Jing Tang
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The Dynamical Biomarkers in Functional Connectivity of Autism Spectrum Disorder Based on Dynamic Graph Embedding Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-12-07 Yanting Liu, Hao Wang, Yanrui Ding
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DCDA: CircRNA–Disease Association Prediction with Feed-Forward Neural Network and Deep Autoencoder Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-11-17 Hacer Turgut, Beste Turanli, Betül Boz
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Comprehensive scRNA-seq Model Reveals Artery Endothelial Cell Heterogeneity and Metabolic Preference in Human Vascular Disease Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-11-17 Liping Zeng, Yunchang Liu, Xiaoping Li, Xue Gong, Miao Tian, Peili Yang, Qi Cai, Gengze Wu, Chunyu Zeng
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Cervical Cancer Classification From Pap Smear Images Using Deep Convolutional Neural Network Models Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-11-14 Sher Lyn Tan, Ganeshsree Selvachandran, Weiping Ding, Raveendran Paramesran, Ketan Kotecha
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Computer-Aided Diagnosis of Complications After Liver Transplantation Based on Transfer Learning Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-10-25 Ying Zhang, Chenyuan Shangguan, Xuena Zhang, Jialin Ma, Jiyuan He, Meng Jia, Na Chen
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A Multi-perspective Model for Protein–Ligand-Binding Affinity Prediction Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-10-10 Xianfeng Zhang, Yafei Li, Jinlan Wang, Guandong Xu, Yanhui Gu
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Combining Global-Constrained Concept Factorization and a Regularized Gaussian Graphical Model for Clustering Single-Cell RNA-seq Data Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-10-10 Yaxin Xu, Wei Zhang, Xiaoying Zheng, Xianxian Cai
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Tumour Growth Mechanisms Determine Effectiveness of Adaptive Therapy in Glandular Tumours Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-09-30 Rui Zhen Tan
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A Novel Deep Learning Model for Medical Image Segmentation with Convolutional Neural Network and Transformer Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-09-04 Zhuo Zhang, Hongbing Wu, Huan Zhao, Yicheng Shi, Jifang Wang, Hua Bai, Baoshan Sun
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CA-UNet Segmentation Makes a Good Ischemic Stroke Risk Prediction Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-08-26 Yuqi Zhang, Mengbo Yu, Chao Tong, Yanqing Zhao, Jintao Han
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Identification of gene-level methylation for disease prediction Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-08-21 Jisha Augustine, A. S. Jereesh
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Classification of Glomerular Pathology Images in Children Using Convolutional Neural Networks with Improved SE-ResNet Module Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-07-31 Xiang-Yong Kong, Xin-Shen Zhao, Xiao-Han Sun, Ping Wang, Ying Wu, Rui-Yang Peng, Qi-Yuan Zhang, Yu-Ze Wang, Rong Li, Yi-Heng Yang, Ying-Rui Lv
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Application of Semi-supervised Fuzzy Clustering Based on Knowledge Weighting and Cluster Center Learning to Mammary Molybdenum Target Image Segmentation Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-07-24 Peng Peng, Danping Wu, Li-Jun Huang, Jianqiang Wang, Li Zhang, Yue Wu, Yizhang Jiang, Zhihua Lu, Khin Wee Lai, Kaijian Xia
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Development of an Expert-Level Right Ventricular Abnormality Detection Algorithm Based on Deep Learning Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-07-20 Zeye Liu, Hang Li, Wenchao Li, Fengwen Zhang, Wenbin Ouyang, Shouzheng Wang, Aihua Zhi, Xiangbin Pan
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StoneNet: An Efficient Lightweight Model Based on Depthwise Separable Convolutions for Kidney Stone Detection from CT Images Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-07-15 Sohaib Asif, Ming Zhao, Xuehan Chen, Yusen Zhu
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Haemodynamic Effects on the Development and Stability of Atherosclerotic Plaques in Arterial Blood Vessel Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-07-07 Weirui Lei, Shengyou Qian, Xin Zhu, Jiwen Hu
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scFED: Clustering Identifying Cell Types of scRNA-Seq Data Based on Feature Engineering Denoising Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-07-04 Yang Liu, Feng Li, Junliang Shang, Jinxing Liu, Juan Wang, Daohui Ge
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Exploring the Binding Mechanism of NRG1–ERBB3 Complex and Discovery of Potent Natural Products to Reduce Diabetes-Assisted Breast Cancer Progression Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-06-30 Sulaiman K. Marafie, Eman Alshawaf, Mohamed Abu-Farha, Thangavel Alphonse Thanaraj, Dong-Qing Wei, Fahd Al-Mulla, Abbas Khan, Jehad Abubaker, Anwar Mohammad
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CD47Binder: Identify CD47 Binding Peptides by Combining Next-Generation Phage Display Data and Multiple Peptide Descriptors Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-06-30 Bowen Li, Heng Chen, Jian Huang, Bifang He
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G4Bank: A database of experimentally identified DNA G-quadruplex sequences Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-06-30 Hong-Sheng Zhong, Mei-Jing Dong, Feng Gao
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LDAEXC: LncRNA–Disease Associations Prediction with Deep Autoencoder and XGBoost Classifier Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-06-12 Cuihong Lu, Minzhu Xie
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Integration of IDPC Clustering Analysis and Interpretable Machine Learning for Survival Risk Prediction of Patients with ESCC Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-05-30 Dan Ling, Anhao Liu, Junwei Sun, Yanfeng Wang, Lidong Wang, Xin Song, Xueke Zhao
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A Self-attention Graph Convolutional Network for Precision Multi-tumor Early Diagnostics with DNA Methylation Data Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-05-29 Xue Jiang, Zhiqi Li, Aamir Mehmood, Heng Wang, Qiankun Wang, Yanyi Chu, Xueying Mao, Jing Zhao, Mingming Jiang, Bowen Zhao, Guanning Lin, Edwin Wang, Dongqing Wei
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CRBP-HFEF: Prediction of RBP-Binding Sites on circRNAs Based on Hierarchical Feature Expansion and Fusion Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-05-26 Zheng Ma, Zhan-Li Sun, Mengya Liu
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BMRI-NET: A Deep Stacked Ensemble Model for Multi-class Brain Tumor Classification from MRI Images Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-05-12 Sohaib Asif, Ming Zhao, Xuehan Chen, Yusen Zhu
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An Improved Soft Subspace Clustering Algorithm Based on Particle Swarm Optimization for MR Image Segmentation Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-05-10 Lei Ling, Lijun Huang, Jie Wang, Li Zhang, Yue Wu, Yizhang Jiang, Kaijian Xia
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Spatial–Temporal EEG Fusion Based on Neural Network for Major Depressive Disorder Detection Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-05-04 Bingtao Zhang, Dan Wei, Guanghui Yan, Xiulan Li, Yun Su, Hanshu Cai
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RNA Folding Based on 5 Beads Model and Multiscale Simulation Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-04-28 Dinglin Zhang, Lidong Gong, Junben Weng, Yan Li, Anhui Wang, Guohui Li
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Identifying Lymph Node Metastasis-Related Factors in Breast Cancer Using Differential Modular and Mutational Structural Analysis Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-04-28 Xingyi Liu, Bin Yang, Xinpeng Huang, Wenying Yan, Yujuan Zhang, Guang Hu
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A Novel Image Encryption Scheme for DNA Storage Systems Based on DNA Hybridization and Gene Mutation Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-04-04 Xiangyu Yao, Ranze Xie, Xiangzhen Zan, Yanqing Su, Peng Xu, Wenbin Liu
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dbMisLoc: A Manually Curated Database of Conditional Protein Mis-localization Events Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-03-31 Ren-Hua Wang, Tao Luo, Yu-Peng Guo, Zi-Xin Yang, He-Yi Zhang, Hong-Yu Hao, Pu-Feng Du
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Cell Features Reconstruction from Gene Association Network of Single Cell Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-03-28 Qingguo Xu, Jiajie Zhu, Yin Luo, Weimin Li
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Deep Learning-Based Modeling of Drug–Target Interaction Prediction Incorporating Binding Site Information of Proteins Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-03-26 Sofia D’Souza, K. V. Prema, S. Balaji, Ronak Shah
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A Novel Deep-Learning-Based CADx Architecture for Classification of Thyroid Nodules Using Ultrasound Images Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-03-28 Volkan Göreke
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Utilization of Deep Convolutional Neural Networks for Accurate Chest X-Ray Diagnosis and Disease Detection Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-03-26 Mukesh Mann, Rakesh P. Badoni, Harsh Soni, Mohammed Al-Shehri, Aman Chandra Kaushik, Dong-Qing Wei
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Predicting Drug Synergy and Discovering New Drug Combinations Based on a Graph Autoencoder and Convolutional Neural Network Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-03-21 Huijun Li, Lin Zou, Jamal A. H. Kowah, Dongqiong He, Lisheng Wang, Mingqing Yuan, Xu Liu
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DNA Sequence Optimization Design of Arithmetic Optimization Algorithm Based on Billiard Hitting Strategy Interdiscip. Sci. Comput. Life Sci. (IF 4.8) Pub Date : 2023-03-15 Linpeng Xie, Siwei Wang, Donglin Zhu, Gangqiang Hu, Changjun Zhou