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Acellular Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions of the Knee: A Minimum 5-Year Follow-Up Study Cartilage (IF 2.8) Pub Date : 2024-03-05 Francesca de Caro, Kristien Vuylsteke, Wouter Van Genechten, Peter Verdonk
ObjectiveA novel aragonite-based scaffold has been developed. In this study, mid-term clinical and magnetic resonance imaging (MRI) results on 12 patients affected by isolated chondral or osteochondral lesions of the knee treated by the scaffold implantation have been evaluated at a mean follow-up of 6.5 (range: 5-8) years.DesignThe study population consisted of 3 females and 9 males, mean age 34.4
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Biomechanical Comparison of All-Suture, All-Inside Meniscus Repair Devices in a Human Cadaveric Meniscus Model Cartilage (IF 2.8) Pub Date : 2024-03-01 Patrick A. Massey, Wayne Scalisi, Carver Montgomery, Drayton Daily, James Robinson, Giovanni F. Solitro
ObjectiveNewer all-suture, all-inside meniscus repair devices utilize soft suture anchors. The purpose of this study was to compare the biomechanical performance of 4 meniscus repair devices in human cadaver menisci: the JuggerStitch (all-suture, all-inside), the FiberStitch (all-suture, all-inside), a polyether ether ketone (PEEK) all-inside, and an inside-out device.DesignForty human cadaver menisci
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The Statistical Fragility of Marrow Stimulation for Cartilage Defects of the Knee: A Systematic Review of Randomized Controlled Trials Cartilage (IF 2.8) Pub Date : 2024-02-26 Avanish Yendluri, Ara Alexanian, Rohit R. Chari, John J. Corvi, Nikan K. Namiri, Junho Song, Michael J. Alaia, Xinning Li, Robert L. Parisien
ObjectiveMarrow stimulation is used to address knee cartilage defects. In this study, we used the fragility index (FI), reverse fragility index (rFI), and fragility quotient (FQ) to evaluate statistical fragility of outcomes reported in randomized controlled trials (RCTs) evaluating marrow stimulation.DesignPubMed, Embase, and MEDLINE were queried for recent RCTs (January 1, 2010-September 5, 2023)
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HSF1 Increases EOGT-Mediated Glycosylation of Notch1 to Promote IL-1β-Induced Inflammatory Injury of Chondrocytes Cartilage (IF 2.8) Pub Date : 2024-02-17 Yuanchi Huang, Wenjie Pan, Huanli Bao, Xiangxiang Sun, Chao Xu, Jianbing Ma
ObjectiveOsteoarthritis (OA) is the most common arthritic disease in humans. Nevertheless, the pathogenic mechanism of OA remains unclear. This study aimed to explore that heat-shock transcription factor 1 (HSF1) facilitated interleukin-1 beta (IL-1β) chondrocyte injury by increasing Notch1 O-linked N-acetylglucosamine (O-GlcNAc) modification level.DesignHuman chondrocytes were incubated with 5 ng/ml
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Prognostic Factors for Clinical Outcome and Cartilage Regeneration after Implantation of Allogeneic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Large-Sized Cartilage Defects with Osteoarthritis Cartilage (IF 2.8) Pub Date : 2024-02-17 Se-Han Jung, Min Jung, Kwangho Chung, Sungjun Kim, Jisoo Park, Junseok Hong, Chong-Hyuk Choi, Sung-Hwan Kim
ObjectiveTo analyze the prognostic factors for clinical outcomes and cartilage regeneration after the implantation of allogeneic human umbilical cord blood mesenchymal stem cell (hUCB-MSC) for treating large-sized cartilage defects with osteoarthritis.DesignThis study is a case-series with multiple subgroup analyses that divides the included patients into multiple subgroups based on various factors
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Reporting of Morphology, Location, and Size in the Treatment of Osteochondral Lesions of the Talus in 11,785 Patients: A Systematic Review and Meta-Analysis Cartilage (IF 2.8) Pub Date : 2024-02-17 Pascal R. van Diepen, Frank F. Smithuis, Julian J. Hollander, Jari Dahmen, Kaj S. Emanuel, Sjoerd A.S. Stufkens, Gino M.M.J. Kerkhoffs
ObjectiveUniformity of reporting is a requisite to be able to compare results of clinical studies on the treatment of osteochondral lesions of the talus (OLT). The primary aim of this study was to evaluate the frequency and quality of reporting of size, morphology, and location of OLTs.DesignA literature search was performed from 1996 to 2023 to identify clinical studies on surgical treatment of OLTs
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Cellular Enhancement of Frozen Meniscus Allograft Combining Native Meniscus and Mesenchymal Stromal Cell Injections Cartilage (IF 2.8) Pub Date : 2024-02-07 Caroline Struijk, Katherine L. Lydon, Martin Husen, Peter Verdonk, Jozef Michielsen, Andre J. van Wijnen, Aaron J. Krych, Daniel B.F. Saris
ObjectiveThis proof-of-concept study investigated an improved cell-based injection therapy combining mesenchymal stem cells (MSCs) and meniscus cells (MCs) to support superior meniscus allograft repopulation and early revival compared to injecting MSCs alone.DesignIn this controlled laboratory study, frozen meniscus allograft samples were injected vertically with a cell suspension containing different
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Second-Look Arthroscopy Shows Inferior Cartilage after Bone Marrow Stimulation Compared with Other Operative Techniques for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis Cartilage (IF 2.8) Pub Date : 2024-02-07 Jelmer T. Vreeken, Jari Dahmen, Tobias Stornebrink, Kaj S. Emanuel, Alex B. Walinga, Sjoerd A.S. Stufkens, Gino M.M.J. Kerkhoffs
ObjectiveTo compare cartilage quality after different surgical interventions for osteochondral lesions of the talus (OLT), evaluated by second-look arthroscopy. Secondary aims were to report concomitant diagnoses, and to correlate cartilage quality with clinical and radiological outcomes. This review hypothesizes that the cartilage repair after bone marrow stimulation (BMS) is inferior to the other
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Effects of Diclofenac Etalhyaluronate (SI-613/ONO-5704) on Cartilage Degeneration in Arthritic Rats and Inflammatory Cytokine-Stimulated Human Chondrocytes Cartilage (IF 2.8) Pub Date : 2024-02-06 Shuhei Takada, Risa Nodera, Keiji Yoshioka
ObjectiveCartilage degeneration is a key feature of osteoarthritis (OA) and rheumatoid arthritis and is thought to negatively impact patients’ quality of life. Diclofenac etalhyaluronate (DEH, SI-613/ONO-5704) is a hyaluronic acid (HA) derivative chemically bound to diclofenac (DF) that has been reported to improve OA symptoms; however, its effect on cartilage degeneration remains unknown. In the present
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Subchondral Bone Alignment in Osteochondral Allograft Transplants for Large Oval Defects of the Medial Femoral Condyle: Comparison of Lateral versus Medial Femoral Condyle Donors Cartilage (IF 2.8) Pub Date : 2024-01-29 Kelly M.R. Taylor, Conor S. Locke, Timothy S. Mologne, William D. Bugbee, John A. Grant
ObjectiveSupply-demand mismatch of medial femoral condyle (MFC) osteochondral allografts (OCAs) remains a rate-limiting factor in the treatment of osteochondral defects of the femoral condyle. Surface contour mapping was used to determine whether a contralateral lateral femoral condyle (LFC) versus ipsilateral MFC OCA differs in the alignment of donor:native subchondral bone for large osteochondral
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Higher Age is Associated with Lower Likelihood of Conversion to Surgery after Primary Nonoperative Treatment for Osteochondral Lesions of the Talus Cartilage (IF 2.8) Pub Date : 2024-01-27 Tristan M.F. Buck, Jari Dahmen, J. Nienke Altink, Quinten G.H. Rikken, Inger N. Sierevelt, Sjoerd A.S. Stufkens, Gino M.M.J. Kerkhoffs
IntroductionThe first line of treatment for osteochondral lesions of the talus (OLT) is nonoperative. To date, there is limited evidence on risk factors that may influence conversion to surgery after primary nonoperative treatment for symptomatic OLTs. The aim of this study was therefore to identify risk factors for conversion to surgery after initial nonoperative treatment of OLTs.MethodsFor this
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Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability Cartilage (IF 2.8) Pub Date : 2024-01-18 Sheena Devasia, Jinu T. Joseph, Stephena P.S., Seiko Koizumi, Liz Clarke, Sriraam V.T., Abhilash Parameswaran Kailas, Shajil Madhavan
ObjectiveThe various functionalities of collagen peptides have generated a large interest in utilizing the bioactive peptides as a nutritional therapy to ameliorate various physiological degenerative conditions. Collagen peptides are observed to reduce the pain and aligned difficulties with respect to osteoarthritis. Here we report the enhanced ameliorating property of novel high-functional “Wellnex”
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Clinical Outcomes After Arthroscopic Treatment of Extraspinal Diffuse Idiopathic Skeletal Hyperostosis (DISH) Involving the Hip Joint Cartilage (IF 2.8) Pub Date : 2024-01-18 Fan Yang, Zhiyu Zhang, Hongjie Huang, Yan Xu, Jianquan Wang, Xiaodong Ju
ObjectiveThe hip joint can be affected by extraspinal diffuse idiopathic skeletal hyperostosis (DISH). This study aimed to compare the clinical characteristics of hips with DISH to those with mixed-type femoroacetabular impingement symptoms (FAIS). In addition, patient-reported outcome (PRO) scores were reported among patients with DISH involving the hip joint who underwent arthroscopic treatment.MethodsA
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The Actin Cytoskeleton as a Regulator of Proteoglycan 4 Cartilage (IF 2.8) Pub Date : 2024-01-06 Sofia Gonzalez-Nolde, Cameron J. Schweiger, Elizabeth E.R. Davis, Thomas J. Manzoni, Samer M.I. Hussein, Tannin A. Schmidt, Stephanie G. Cone, Gregory D. Jay, Justin Parreno
ObjectiveThe superficial zone (SZ) of articular cartilage is responsible for distributing shear forces for optimal cartilage loading and contributes to joint lubrication through the production of proteoglycan 4 (PRG4). PRG4 plays a critical role in joint homeostasis and is chondroprotective. Normal PRG4 production is affected by inflammation and irregular mechanical loading in post-traumatic osteoarthritis
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Current Lack of Evidence on Treatment Strategies and Clinical Outcomes for Osteochondral Lesions of the Subtalar, Talonavicular, and Calcaneocuboid Joints: A Systematic Review. Cartilage (IF 2.8) Pub Date : 2023-11-30 Yoshiharu Shimozono,Stefan Rammelt,Masato Takao
OBJECTIVE In contrast to osteochondral lesion (OCL) of the ankle, OCLs in other joints of the foot, such as subtalar joint, talonavicular joint, calcaneocuboid joint, and the midfoot, are rare conditions, but they can also lead to significant morbidity. The objective of this systematic review was to summarize the clinical evidence for the treatment of OCLs of the subtalar, talonavicular, calcaneocuboid
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Characterization of the Age-Related Differences in Porcine Acetabulum and Femoral Head Articular Cartilage. Cartilage (IF 2.8) Pub Date : 2023-11-29 Nathan P Fackler,Ryan P Donahue,Benjamin J Bielajew,Arya Amirhekmat,Jerry C Hu,Kyriacos A Athanasiou,Dean Wang
OBJECTIVE The use of porcine animal models for cartilage injury has increased recently due to their similarity with humans with regard to cartilage thickness, limited intrinsic healing of chondral defects, and joint loading biomechanics. However, variations in the mechanical and biochemical properties of porcine hip articular cartilage among various tissue ages and weightbearing (WB) regions are still
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Novel-miR-81 Promotes the Chondrocytes Differentiation of Bone Marrow Mesenchymal Stem Cells Through Inhibiting Rac2 Expression. Cartilage (IF 2.8) Pub Date : 2023-11-24 Ziwei Luo,Jinqi Xie,Haoxiang Ye,Jie Zhang,Yangping Liu,Chunmei Ma,Jiahui Cao,Hao Pan,Xiaosheng Liu,Xianxi Zhou,Jiechen Kong,Dongfeng Chen,Aijun Liu
OBJECTIVE MicroRNAs (miRNAs) play a key role in the differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. Our previous study found that novel-miR-81 can relieve osteoarthritis, but its role in chondrogenic differentiation of BMSCs remains unclear. The purpose of this study was to explore the role of novel-miR-81 in chondrogenic differentiation of BMSCs. METHODS We
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Micro-223 Promotes Diabetic Osteoarthritis Progression by Regulating Cartilage Degeneration and Subchondral Bone Remodeling. Cartilage (IF 2.8) Pub Date : 2023-11-23 Yao Li,Ting Fu,Yi Zhao,Long-Jie Yuan,Bai-Bai Wang,Jian Guan,Hua-Jun Wang,Ling Li,Yan-Ping Gao
OBJECTIVE Our study was performed to investigate whether micro-223 promotes diabetic Osteoarthritis (OA) progression by regulating cartilage degeneration and subchondral bone remodeling. METHODS The expression of miR-223 in human normal cartilage, OA cartilage, and subchondral bone tissue with or without DM was detected by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR)
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Integrin α10β1-Selected Mesenchymal Stem Cells Reduce Pain and Cartilage Degradation and Increase Immunomodulation in an Equine Osteoarthritis Model. Cartilage (IF 2.8) Pub Date : 2023-11-21 Camilla Andersen,Stine Jacobsen,Kristina Uvebrant,John F Griffin,Lucienne Angela Vonk,Marie Walters,Lise Charlotte Berg,Evy Lundgren-Åkerlund,Casper Lindegaard
OBJECTIVE Integrin α10β1-selected mesenchymal stem cells (integrin α10-MSCs) have previously shown potential in treating cartilage damage and osteoarthritis (OA) in vitro and in animal models in vivo. The aim of this study was to further investigate disease-modifying effects of integrin α10-MSCs. DESIGN OA was surgically induced in 17 horses. Eighteen days after surgery, horses received 2 × 107 integrin
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Analysis of Molecular Changes and Features in Rat Knee Osteoarthritis Cartilage: Progress From Cellular Changes to Structural Damage. Cartilage (IF 2.8) Pub Date : 2023-11-17 Zixi Zhao,Akira Ito,Hiroshi Kuroki,Tomoki Aoyama
OBJECTIVE Although knee osteoarthritis (KOA) is a common disease, there is a lack of specific prevention and early treatment methods. Hence, this study aimed to examine the molecular changes occurring at different stages of KOA to elucidate the dynamic nature of the disease. DESIGN Using a low-force compression model and analyzing RNA sequencing data, we identified molecular changes in the transcriptome
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Large Variations in Resistance to Degradation between Hyaluronic Acid Viscosupplements: A Comparative Rheological Study. Cartilage (IF 2.8) Pub Date : 2023-11-09 Guillaume Darsy,Jeremy Patarin,Thierry Conrozier
AIM To compare the resistance to degradation of linear and cross-linked viscosupplements using a rheological model combining mechanical and oxidative stresses, mimicking what happens inside the joint following HA injection. METHODS The rheological properties of 8 HAs were measured using a stress-imposed Rheometer DHR3. Strain sweeps were carried out to evaluate the rheological properties at rest from
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Letter to Editor Regarding Article, "Improved 2-Year Freedom From Arthroplasty in Patients With High-Risk SIFK Scores and Medial Knee Osteoarthritis Treated With an Implantable Shock Absorber Versus Non-Operative Care". Cartilage (IF 2.8) Pub Date : 2023-11-08 Jingzhi Wang,Caining Wen,Yuanmin Zhang
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Osteochondral Allograft Transplantation in the Shoulder: A Systematic Review of Indications and Outcomes. Cartilage (IF 2.8) Pub Date : 2023-11-08 Brian Prigmore,Suzanne Tabbaa,Dennis C Crawford
OBJECTIVE To collate current literature pertaining to the published reports of indications for, and outcomes of, osteochondral allograft (OCA) transplantations in the shoulder so as to guide surgeons in the management of various etiologies of osteochondral lesions in this joint. DESIGN A systematic review of the current literature was performed in February 2022 in the PubMed, Cochrane, and EMBASE databases
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Prospective Outcomes of a Biological Resurfacing Arthroplasty with Fascia Lata Autograft (BioJoint) for the Treatment of Osteoarthritis of the Midtarsal Joint Complex. Cartilage (IF 2.8) Pub Date : 2023-10-27 Jari Dahmen,Sjoerd A S Stufkens,Gino M M J Kerkhoffs
OBJECTIVE To determine the clinical, safety, and radiological outcomes after biological resurfacing arthroplasty for the treatment of osteoarthritis (OA) of one or more joints of the midtarsal joint complex. DESIGN All prospectively followed patients with OA to one of or multiple joints of the midtarsal joint complex who were operated with a biological resurfacing arthroplasty with a fascia lata autograft
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Response to Comments by Zhao et al. Regarding "Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma". Cartilage (IF 2.8) Pub Date : 2023-10-26 Miguel A Khoury,Karim Chamari,Montassar Tabben,Khalid Alkhelaifi,Emmanuel Papacostas,Theodorakys Marín Fermín,Markus Laupheimer,Pieter D'Hooghe
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Costal Cartilage Graft Repair Osteochondral Defect in a Mouse Model. Cartilage (IF 2.8) Pub Date : 2023-10-26 Yidan Pang,Yiyang Ma,Kaiwen Zheng,Siyuan Zhu,Hongyu Sui,Hao Ren,Kang Liu,Wei Li,Yigang Huang,Dajiang Du,Junjie Gao,Changqing Zhang
OBJECTIVE Osteochondral defects develop into osteoarthritis without intervention. Costal cartilage can be utilized as an alternative source for repairing osteochondral defect. Our previous clinical study has shown the successful osteochondral repair by costal cartilage graft with integration into host bone bed. In this study, we investigate how cartilaginous graft adapt to osteochondral environment
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α2-Macroglobulin Promotes Chondrocyte Proliferation and Cartilage Matrix Synthesis via Inducing PCNA. Cartilage (IF 2.8) Pub Date : 2023-10-23 Hailing Guo,Shaowei Wang,Yang Zhang,Jian Sun,Li Guo,Jian Pang,Hongsheng Zhan
OBJECTIVES α2-Macroglobulin (A2M) can prevent cartilage degeneration by blocking many types of cartilage-degrading enzymes, but the mechanism remains to be clarified. This study aimed to test that A2M protects against cartilage degeneration by promoting chondrocyte proliferation and cartilage matrix synthesis via inducing proliferating cell nuclear antigen (PCNA). DESIGN The cartilage degeneration
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Treatment of Articular Cartilage Defects: A Descriptive Analysis of Clinical Characteristics and Global Trends Reported from 2001 to 2020. Cartilage (IF 2.8) Pub Date : 2023-10-18 Zhiyuan Ren,Yang Liu,Yongsheng Ma,Lingan Huang,Xueding Wang,Qitai Lin,Yugang Xing,Wenming Yang,Wangping Duan,Xiaochun Wei
PURPOSE To evaluate the clinical characteristics and global trends in the surgical treatment of articular cartilage defects. METHODS Studies in English published between January 1, 2001 and December 31, 2020 were retrieved from MEDLINE, WOS, INSPEC, SCIELO, KJD, and RSCI on the "Web of Science." Patient data were extracted, including age, sex, defect location and laterality, duration of follow-up and
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Multi-Surface Cartilage Defects about the Knee Treated with Cartilage Restoration Procedures Show Good Outcomes and Survivorship at Minimum 2-Year Follow-Up. Cartilage (IF 2.8) Pub Date : 2023-10-18 Julia S Retzky,Guilherme M Palhares,Morgan Rizy,Paige Hinkley,Andreas H Gomoll,Sabrina M Strickland
OBJECTIVE We aimed to evaluate the outcomes, survivorship, and complications following multi-surface cartilage procedures at minimum 2-year follow-up. DESIGN Patients with either (1) single-surface osteochondral allograft transplantation (OCAT) with third-generation matrix-induced autologous cultured chondrocyte implantation (MACI) or particulated juvenile cartilage implantation (DeNovo), or (2) multiple-surface
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A Novel Update on the Management of Müller-Weiss Disease: Presentation of a Treatment Algorithm. Cartilage (IF 2.8) Pub Date : 2023-10-18 Chayanin Angthong,Alastair S E Younger,Bavornrit Chuckpaiwong,Thos Harnroongroj,Andrea Veljkovic
OBJECTIVE Müller-Weiss disease (MWD) is a challenging condition involving the perinavicular region in the initial stages and subsequently the entire foot in the later stages. The goal of this article is to describe the pathomechanics, clinical evaluation, and nonoperative and operative treatment, including a treatment algorithm, based on current evidence and the combined authors' experience. DESIGN
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Asymmetric Post-Traumatic Knee Arthritis Is Closely Correlated With Both Severity and Time for Lower Limb Coronal Plane Malalignment. Cartilage (IF 2.8) Pub Date : 2023-10-17 Luke E Visscher,Cathal McCarthy,Jordy White,Kevin Tetsworth
OBJECTIVE Mechanical alignment of the lower limbs has been suggested to cause abnormal uneven loading across the compartments at the knee, but its contribution to the initiation and progression of arthritis remains controversial. This study aimed to establish whether malalignment of the lower limb after trauma is associated with worsened arthritis scores in the theoretically overloaded compartment
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Ultra-Short Echo Time-MRI T2* Mapping of Articular Cartilage Layers Is Associated with Histological Early Degeneration. Cartilage (IF 2.8) Pub Date : 2023-10-16 Rui Imamura,Atsushi Teramoto,Yasutaka Murahashi,Yohei Okada,Shinichiro Okimura,Yoshihiro Akatsuka,Kota Watanabe,Toshihiko Yamashita
OBJECTIVE Ultra-short TE (UTE) sequences on MRI are a technique that improves the visualization of tissues with short T2 relaxation time, such as deep cartilage layers. In addition, T2* relaxation time calculated from the UTE has the potential to evaluate water molecules bound to the cartilage matrix. This study was performed to determine if there is an association between UTE-T2* relaxation time by
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In Vitro Evaluation of Lateral Femur Condyle Free Chondral Fragment Swelling after Soaking in Normal Saline. Cartilage (IF 2.8) Pub Date : 2023-10-16 Carver Montgomery,Wayne Scalisi,James Robinson,William Sherman,Giovanni F Solitro,Patrick Massey
OBJECTIVE After traumatic knee injuries, chondral fragments can avulse off bone with the progeny fragment becoming a loose body. The loose fragment may be larger than expected when trying to surgically repair the fragment back to its original site. The purpose of this study was to determine whether a loose chondral fragment from the lateral femur condyle would increase in size and weight after soaking
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The Influence of Knee Position on Ultrasound Imaging of Femoral Cartilage in Individuals with Anterior Cruciate Ligament Reconstruction. Cartilage (IF 2.8) Pub Date : 2023-10-16 Harry S Battersby,Skylar C Holmes,Eric J Shumski,Caitlyn E Heredia,Steven A Garcia,Derek N Pamukoff
BACKGROUND Articular cartilage is important for knee function and can be imaged using ultrasound. The purpose was to compare femoral cartilage thickness and echo intensity (EI) measured at 90° and 140° of knee flexion and between limbs in a cohort with unilateral anterior cruciate ligament reconstruction (ACLR). We also examined associations between gait biomechanics and cartilage outcomes. METHODS
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Development of a Novel Rat Knee Osteoarthritis Model Induced by Medial Meniscus Extrusion. Cartilage (IF 2.8) Pub Date : 2023-10-14 Daisuke Fukui,Daisuke Nishiyama,Manabu Yamanaka,Hidenobu Tamai,Naoko Nishio,Mamoru Kawakami,Hiroshi Yamada
OBJECTIVE The medial meniscus extrusion (MME) is associated with increased stress on the knee joint, which leads to cartilage degeneration. To evaluate the etiology of knee osteoarthritis, it is extremely important to create animal models of the disease that more closely resemble actual clinical conditions in terms of symptomatology, molecular biology, and histology. This study aimed to create a clinically
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Kinesiophobia and Pain Catastrophizing Leads to Decreased Return to Sport Following Autologous Chondrocyte Implantation but Does Not Affect Return to Work. Cartilage (IF 2.8) Pub Date : 2023-10-10 Jairo Triana,Naina Rao,Michael Buldo-Licciardi,Ariana Lott,Nicole D Rynecki,Jordan Eskenazi,Michael J Alaia,Laith M Jazrawi,Eric J Strauss,Kirk A Campbell
OBJECTIVE To evaluate the effect of fear of reinjury on return to sport (RTS), return to work (RTW), and clinical outcomes following autologous chondrocyte implantation (ACI). DESIGN A retrospective review of patients who underwent ACI with a minimum of 2 years in clinical follow-up was conducted. Patient-reported outcomes collected included the Visual Analog Scale (VAS) and Knee Injury and Osteoarthritis
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Evidence-Based Treatment Algorithm for Freiberg Disease. Cartilage (IF 2.8) Pub Date : 2023-10-10 Ichiro Yoshimura,Masato Takao,Emilio Wagner,Sjoerd Stufkens,Jari Dahmen,Gino M M J Kerkhoffs,Mark Glazebrook
Freiberg disease is a type of osteonecrosis of the metatarsal head that predominantly occurs in young females and adolescents, although it may occur at any age. The pathophysiology is multifactorial and may involve trauma, altered foot biomechanics, systemic disorders, and arterial insufficiency. The most typical location is the second metatarsal head, but Freiberg disease may also occur in other lesser
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Letter to Editor Regarding Article "Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma". Cartilage (IF 2.8) Pub Date : 2023-10-05 Sheng Zhao,Caining Wen,Yuanmin Zhang
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Osteochondral Lesions of the Subtalar Joint: Clinical Outcomes in 11 Patients. Cartilage (IF 2.8) Pub Date : 2023-10-05 Tristan M F Buck,James J Butler,Mohammad T Azam,Carlijn Ter Laak Bolk,Quinten G H Rikken,Matthew B Weiss,Jari Dahmen,Sjoerd A S Stufkens,John G Kennedy,Gino M M J Kerkhoffs
OBJECTIVE The purpose of this retrospective case series was to evaluate clinical outcomes following both conservative treatment and arthroscopic bone marrow stimulation (BMS) for the management of symptomatic subtalar osteochondral lesions (OCLs). DESIGN All symptomatic subtalar OCLs with a minimum of 12 months follow-up having undergone either a conservative management or arthroscopic procedure were
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Back in Action: High Return to Pre-Injury Level of Sports after Arthroscopic Bone Marrow Stimulation for Osteochondral Lesions of the First Metatarsophalangeal (MTP-1) Joint. Cartilage (IF 2.8) Pub Date : 2023-09-21 Carlijn S Ter Laak Bolk,Quinten G H Rikken,Jari Dahmen,Yoshiharu Shimozono,Masato Takao,Sjoerd A S Stufkens,Gino M M J Kerkhoffs
OBJECTIVE The primary aim was to assess the return to sports outcomes of patients with symptomatic osteochondral lesions (OCLs) to the first metatarsophalangeal (MTP-1) joint treated by arthroscopic bone marrow stimulation (BMS). Secondary aims were to present patient-reported outcome measures (PROMs) on pain scores as well as surgery-related complications or reoperations to the MTP-1 joint. DESIGN
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METTL3 Regulates the m6A Modification of NEK7 to Inhibit the Formation of Osteoarthritis. Cartilage (IF 2.8) Pub Date : 2023-09-19 Xiaochuan Xiong,Hao Xiong,Jun Peng,Yingjie Liu,Yang Zong
OBJECTIVE Osteoarthritis (OA) is a common degenerative joint disease. The occurrence of OA slowly destroys the soft tissue structure of the patient's joint. Severe cases could lead to disability. Current studies had shown that inhibition of chondrocytes pyroptosis could slow down the progression of OA. Our work aimed to explore the specific mechanisms and ways of regulating this process. DESIGN In
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Femoroacetabular Impingement and the Effect of Osteochondroplasty on Hip Osteoarthritis Prevention: The Pandora's Box Opening Process. Cartilage (IF 2.8) Pub Date : 2023-09-18 José M Lamo-Espinosa,Jorge Gómez-Álvarez,Elena Pascual Roquet-Jalmar,Asier Iribarren,Anne Recke,María Cruz Roa,Andrés Valentí-Azcárate,Froilán Granero-Moltó,Mikel San-Julián
OBJECTIVE This study was conducted to assess the effect of osteochondroplasty on osteoarthritis (OA) prevention, comparing radiological evolution between identical hips from the same patient who had undergone unilateral surgery. DESIGN We retrospectively reviewed radiological evolution between hips with similar shape from the same patient who had undergone unilateral surgery. In all, 56 FAI patients
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Parallel Chondrogenesis and Osteogenesis Tissue Morphogenesis in Muscle Tissue via Combinations of TGF-β Supergene Family Members. Cartilage (IF 2.8) Pub Date : 2023-09-15 Fei Xiong,Yan Chevalier,Roland M Klar
OBJECTIVE This study aimed to decipher the temporal and spatial signaling code for clinical cartilage and bone regeneration. We investigated the effects of continuous equal dosages of a single, dual, or triplicate growth factor combination of bone morphogenetic protein (BMP)-2, transforming growth factor (TGF)-β3, and/or BMP-7 on muscle tissue over a culturing period. The hypothesis was that specific
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Decreased Elastic Modulus of Knee Articular Cartilage Based on New Macroscopic Methods Accurately Represents Early Histological Findings of Degeneration. Cartilage (IF 2.8) Pub Date : 2023-09-01 Takahiro Maeda,Shinichi Kuriyama,Shigeo Yoshida,Kohei Nishitani,Shinichiro Nakamura,Shuichi Matsuda
OBJECTIVE Ex vivo nanoindentation measurement has reported that elastic modulus decreases as cartilage degenerates, but no method has been established to macroscopically evaluate mechanical properties in vivo. The objective of this study was to evaluate the elastic modulus of knee joint cartilage based on macroscopic methods and to compare it with gross and histological findings of degeneration. DESIGN
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Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat-High-Sucrose Diet in a Rat Model. Cartilage (IF 2.8) Pub Date : 2023-09-01 Nada Abughazaleh,Kevin Boldt,Jaqueline Lourdes Rios,Stela Marcia Mattiello,Kelsey H Collins,Ruth-Anne Seerattan,Walter Herzog
OBJECTIVE Obesity and associated low-level local systemic inflammation have been linked to an increased rate of developing knee osteoarthritis (OA). Aerobic exercise has been shown to protect the knee from obesity-induced joint damage. The aims of this study were to determine (1) if resistance training provides beneficial metabolic effects similar to those previously observed with aerobic training
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Il-1β Promotes Superficial Zone Cells Senescence in Articular Cartilage by Inhibiting Autophagy. Cartilage (IF 2.8) Pub Date : 2023-08-31 Wei Xu,Juan Wang,Lin Cui,Chen Huang,Ning Xia,Meiming Xie,Da Liu,Dongfa Liao
OBJECTIVE The superficial zone cells in articular cartilage (SFZCs) have been identified as stem/progenitor chondrocytes and promoted cell self-renewal in the osteoarthritis (OA). Several studies emphasized the involvement of senescence and autophagy in OA. Interleukin-1β (IL-1β) is one of the main inflammatory mediators of OA, and whether it induces senescence and autophagy in SFZCs remains unclear
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Upregulated Mitochondrial Dynamics Is Responsible for the Procatabolic Changes of Chondrocyte Induced by α2-Adrenergic Signal Activation. Cartilage (IF 2.8) Pub Date : 2023-08-30 Jiaying He,Wenpin Qin,Yusong Zhang,Jianfei Yan,Xiaoxiao Han,Jialu Gao,Qihong Li,Kai Jiao
OBJECTIVE Activation of sympathetic tone is important for cartilage degradation in osteoarthritis (OA). Recent studies reported that sympathetic signals can affect the mitochondrial function of target cells. It is unknown whether this effect exits in chondrocytes and affects chondrocyte catabolism. The contribution of mitochondrial dynamics in the activation of α2-adrenergic signal-mediated chondrocyte
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Safety and Efficacy of a Novel Polyglycolic Acid Meniscal Scaffold for Irreparable Meniscal Tear. Cartilage (IF 2.8) Pub Date : 2023-08-25 Shuhei Otsuki,Shunsuke Sezaki,Yoshinori Okamoto,Takashi Ishitani,Hitoshi Wakama,Masashi Neo
OBJECTIVE Meniscal tears treated with a partial meniscectomy could induce knee osteoarthritis, thereby altering or damaging knee kinetics and biomechanics. We have developed a meniscal scaffold made of polyglycolic acid (PGA) coated with polylactic acid/caprolactone (PGA scaffold), which could induce new tissue growth of meniscus-like tissue. This study aimed to evaluate the safety and efficacy of
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Low-Grade Inflammatory Mediators and Metalloproteinases Yield Synchronous and Delayed Responses to Mechanical Joint Loading. Cartilage (IF 2.8) Pub Date : 2023-08-24 Conner W Hutcherson,Michelle Mao,Bhaskar Thakur,Yasin Y Dhaher
OBJECTIVE Mechanical loading is an essential factor for the maintenance of joint inflammatory homeostasis and the sensitive catabolic-anabolic signaling cascade involved in maintaining cartilage tissue health. However, abnormal mechanical loading of the joint structural tissues can propagate joint metabolic dysfunction in the form of low-grade inflammation. To date, few studies have attempted to delineate
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Early Complication Rates Are Equivalent Between Isolated Cartilage Restoration and Concomitant Cartilage Restoration and Osteotomy of the Knee. Cartilage (IF 2.8) Pub Date : 2023-08-17 Hunter Bohlen,Theofilos Karasavvidis,Deborah Wen,Francis K L Wong,Dean Wang
OBJECTIVE Realignment osteotomy performed concomitantly with cartilage restoration typically requires early restricted weightbearing and can add significant morbidity, potentially leading to an increased risk of early perioperative complications. The purpose of this study was to compare the 30-day complication rates after isolated cartilage restoration (ICR) versus concomitant cartilage restoration
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Osteoarthritis Disease Severity in the Temporomandibular Joint and the Knee Joint: A Comparative Cadaveric Study. Cartilage (IF 2.8) Pub Date : 2023-08-08 Jessica A Immonen,Jason Ciccotelli,Linh M Nguyen,Lesley Gilmer,Landen Broadhead,Mackenzie Kitchen,Conner Paul,Jeremy James
OBJECTIVE The objective of this study was to determine the level of disease severity in a pilot cohort of temporomandibular joints (TMJs) and compare them to the pathology findings previously characterized in cadaveric knee joints. DESIGN Thirty-one intact TMJs from 17 cadaveric donors were harvested and arthritic lesioning seen in the knee joint was investigated on the condyle and the fossa of the
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Minced Cartilage Implantation in Acetabular Cartilage Defects: Case Series with 2-Year Results. Cartilage (IF 2.8) Pub Date : 2023-08-03 Sebastian Gebhardt,Andre Hofer,Georgi I Wassilew,Christian Sobau,Alexander Zimmerer
OBJECTIVE The objective was to evaluate clinical outcome and safety of arthroscopic, autologous minced cartilage implantation for acetabular cartilage lesions observed during hip arthroscopy to treat femoroacetabular impingement syndrome (FAIS). DESIGN Eleven male patients, average age: 29.4 ± 5.4 years, average body mass index (BMI): 24.2 ± 2.2 kg/m2, scheduled for hip arthroscopy due to FAIS accompanied
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Predilection of Patellofemoral Cartilage Lesions in Patients with Posterior Medial Meniscal Root Lesions. Cartilage (IF 2.8) Pub Date : 2023-07-26 Rachel A Loyst,Guilherme Palhares,Paige Hinkley,Morgan Rizy,Alissa J Burge,Andreas H Gomoll,Sabrina M Strickland
OBJECTIVE The present study aims to compare the presence and severity of patellofemoral osteoarthritis between patients with root lesions and non-root lesions. DESIGN A total of 102 patients were included in this study (51 root lesions and 51 non-root lesions). The root lesion cohort was matched to a non-root lesion cohort based on sex, body mass index, and age at the time of surgery. Radiographic
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PKC-δ Promotes IL-1β-Induced Apoptosis of Rat Chondrocytes and Via Activating JNK and P38 MAPK Pathways. Cartilage (IF 2.8) Pub Date : 2023-07-25 Jinfeng Lu,Miao Yu,Jia Li
OBJECTIVE Protein kinase C-delta (PKC-δ) is involved in apoptosis. This study aimed to establish whether PKC-δ can further promote IL-1β-induced chondrocyte apoptosis by mediating the phosphorylation of the JNK and p38 mitogen-activated protein kinase (MAPK) signaling pathways In osteoarthritis (OA). METHODS We employed chondrocyte staining to determine the extent of cartilage degeneration. PKC-δ and
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PiRNA hsa_piR_019914 Promoted Chondrocyte Anabolic Metabolism By Inhibiting LDHA-Dependent ROS Production. Cartilage (IF 2.8) Pub Date : 2023-07-11 YuXuan Gao,Wen Yan,Liangye Sun,XiaoLing Zhang
OBJECTIVES Osteoarthritis (OA) is the most common joint disease. The occurrence and progression of OA are regulated by epigenetics. A large number of studies have shown the important regulatory role of noncoding RNAs in joint diseases. As the largest class of noncoding small RNAs, the importance of piRNAs in many diseases, especially cancer, has been increasingly recognized. However, few studies have
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Young Age and Concomitant or Prior Bony Realignment Procedures are Associated with Decreased Risk of Failure of Osteochondral Allograft Transplantation in the Knee: A Nationwide Database Study. Cartilage (IF 2.8) Pub Date : 2023-07-03 Rory A Byrne,J Alex Albright,Timothy A Reiad,Luca Katz,Joseph Cusano,Alan H Daniels,Brett D Owens
OBJECTIVE Osteochondral allograft (OCA) transplantation is a restorative surgical option for large, full-thickness chondral or osteochondral defects in the knee. Variability in outcomes reporting has led to a broad range of graft survival rates. Using rate of salvage surgery following OCA as a failure metric, the purpose of this study was to analyze the incidence and risk factors for failure in a nationwide
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Knee Osteoarthritis: Clinical and MRI Outcomes After Multiple Intra-Articular Injections With Expanded Autologous Adipose-Derived Stromal Cells or Platelet-Rich Plasma. Cartilage (IF 2.8) Pub Date : 2023-06-22 Miguel A Khoury,Karim Chamari,Montassar Tabben,Khalid Alkhelaifi,Emmanuel Papacostas,Theodorakys Marín Fermín,Markus Laupheimer,Pieter D Hooghe
OBJECTIVE To directly compare clinical and MRI outcomes of multiple intra-articular injections of adipose-derived stromal cells (ASCs) or platelet-rich plasma (PRP) in patients with knee osteoarthritis (OA). DESIGN We retrospectively compared 24-month outcomes in (1) 27 patients receiving 3-monthly intra-articular injections with a total of 43.8 million ASCs and (2) 23 patients receiving 3-monthly
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Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties. Cartilage (IF 2.8) Pub Date : 2023-06-14 Eric Ferkel,Ajay Manjoo,Damion Martins,Mohit Bhandari,Paul Sethi,Mathew Nicholls
INTRODUCTION There are many intra-articular hyaluronic acid (IA-HA) products on the market that have known intrinsic differences in molecular size, source, and structure. The current review summarizes existing evidence describing and assessing these differences, while also identifying whether these differences have an impact on clinical outcomes. METHODS This systematic review summarized all literature
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Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis. Cartilage (IF 2.8) Pub Date : 2023-06-13 Julie Legrand,Claire Marzin,Tuhina Neogi,Laurène Norberciak,Jean-François Budzik,Tristan Pascart
OBJECTIVE To characterize dual-energy computed tomography (DECT) changes depicting hyaline cartilage changes in gout patients with and without osteoarthritis (OA) and in comparators without gout. DESIGN Patients with suspected crystal-associated arthropathy were enrolled and underwent bilateral DECT scans of the knees. Standardized regions of interest were defined in the femorotibial hyaline cartilage
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A Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 Levels in Chondrocytes of Different Morphology within Nondegenerate and Early Osteoarthritic Human Femoral Head Cartilage. Cartilage (IF 2.8) Pub Date : 2023-06-05 Arthur O F Herren,Anish K Amin,Andrew C Hall