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p53 biology and reactivation for improved therapy in MDS and AML Biomark. Res. (IF 11.1) Pub Date : 2024-03-13 Joanna E. Zawacka
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) originate from preleukemic hematopoietic conditions, such as clonal hematopoiesis of indeterminate potential (CHIP) or clonal cytopenia of undetermined significance (CCUS) and have variable outcomes despite the successful implementation of targeted therapies. The prognosis differs depending on the molecular subgroup. In patients with TP53
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STAT3–mediated up-regulation of DAB2 via SRC-YAP1 signaling axis promotes Helicobacter pylori-driven gastric tumorigenesis Biomark. Res. (IF 11.1) Pub Date : 2024-03-13 Yantao Duan, Pengfei Kong, Mingzhu Huang, Yonghao Yan, Yi Dou, Binhao Huang, Jing Guo, Wei Kang, Caixia Zhu, Yuyan Wang, Donglei Zhou, Qiliang Cai, Dazhi Xu
Helicobacter pylori (H pylori) infection is the primary cause of gastric cancer (GC). The role of Disabled-2 (DAB2) in GC remains largely unclear. This study aimed to investigate the role of DAB2 in H pylori-mediated gastric tumorigenesis. We screened various datasets of GC to analyze DAB2 expression and cell signaling pathways. DAB2 expression was assessed in human GC tissue microarrays. H pylori
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Combined TP53 status in tumor-free resection margins and circulating microRNA profiling predicts the risk of locoregional recurrence in head and neck cancer Biomark. Res. (IF 11.1) Pub Date : 2024-03-05 Ganci Federica, Allegretti Matteo, Frascolla Carlotta, Spinella Francesca, Rollo Francesca, Sacconi Andrea, De Pascale Valentina, Palcau Alina Catalina, Manciocco Valentina, Vescovo Mariavittoria, Cotroneo Ettore, Blandino Francesca, Benevolo Maria, Covello Renato, Muti Paola, Strano Sabrina, Vidiri Antonello, Fontemaggi Giulia, Pellini Raul, Blandino Giovanni
Locoregional recurrences represent a frequently unexpected problem in head and neck squamous cell carcinoma (HNSCC). Relapse often (10–30%) occurs in patients with histologically negative resection margins (RMs), probably due to residual tumor cells or hidden pre-cancerous lesions in normal mucosa, both missed by histopathological examination. Therefore, definition of a ‘clean’ or tumor-negative RM
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Serum metabolite signatures of cardiac function and morphology in individuals from a population-based cohort Biomark. Res. (IF 11.1) Pub Date : 2024-03-05 Juliane Maushagen, Nuha Shugaa Addin, Christopher Schuppert, Cavin K. Ward-Caviness, Johanna Nattenmüller, Jerzy Adamski, Annette Peters, Fabian Bamberg, Christopher L. Schlett, Rui Wang-Sattler, Susanne Rospleszcz
Changes in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular disease (CVD) pathway dysregulations and potential CVD risk factors. We aimed to explore associations of cardiac function and morphology, evaluated using magnetic resonance imaging (MRI) with a large panel of serum metabolites. Cross-sectional data from CVD-free individuals
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The role of kinesin family members in hepatobiliary carcinomas: from bench to bedside Biomark. Res. (IF 11.1) Pub Date : 2024-03-03 Kai Zhao, Xiangyu Li, Yunxiang Feng, Jianming Wang, Wei Yao
As a major component of the digestive system malignancies, tumors originating from the hepatic and biliary ducts seriously endanger public health. The kinesins (KIFs) are molecular motors that enable the microtubule-dependent intracellular trafficking necessary for mitosis and meiosis. Normally, the stability of KIFs is essential to maintain cell proliferation and genetic homeostasis. However, aberrant
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RUNX1 promotes angiogenesis in colorectal cancer by regulating the crosstalk between tumor cells and tumor associated macrophages Biomark. Res. (IF 11.1) Pub Date : 2024-02-28 Xuxue Guo, Haonan Zhang, Chengcheng He, Kaiwen Qin, Qiuhua Lai, Yuxin Fang, Qianhui Chen, Weize Li, Yiqing Wang, Xinke Wang, Aimin Li, Side Liu, Qingyuan Li
Colorectal cancer (CRC) is a common malignancy worldwide. Angiogenesis and metastasis are the critical hallmarks of malignant tumor. Runt-related transcription factor 1 (RUNX1), an efficient transcription factor, facilitates CRC proliferation, metastasis and chemotherapy resistance. We aimed to investigate the RUNX1 mediated crosstalk between tumor cells and M2 polarized tumor associated macrophages
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Correction: A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma Biomark. Res. (IF 11.1) Pub Date : 2024-02-27 Aditi Patel, Parina Patel, Dushyant Mandlik, Kaustubh Patel, Pooja Malaviya, Kaid Johar, Krishna B.S Swamy, Shanaya Patel, Vivek Tanavde
Biomarker Research (2023) 11:64 https://doi.org/10.1186/s40364-023-00505-5 The original article contains a typo in the mention of miR-let7a on page 3. The miRNA under investigation is miR-let7i as mentioned in the figure, results section and supplementary data. Authors and Affiliations Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, 380009, Ahmedabad, Gujarat, India
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Correction: HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma Biomark. Res. (IF 11.1) Pub Date : 2024-02-16 Zhipeng Li, Huaxin Zhou, Zhijia Xia, Tong Xia, Gang Du, Strohmer Dorothee Franziska, Xiaoming Li, Xiangyu Zhai, Bin Jin
Correction: Biomark Res 11, 33 (2023) https://doi.org/10.1186/s40364-023-00473-w The authors found that an identical image (HUCCT1-Combine) was unintentionally overlaid in another region (HUCCT1-shHMGA1-1) of Fig. 6C, as a result of a malfunction in the AI import system (Adobe Illustrator CS5). Fig. 6 PF-04691502 works synergistically with palbociclib to inhibit iCCA growth, EMT and stemness in vitro
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Biomarkers and prognostic factors of PD-1/PD-L1 inhibitor-based therapy in patients with advanced hepatocellular carcinoma Biomark. Res. (IF 11.1) Pub Date : 2024-02-14 Nan Zhang, Xu Yang, Mingjian Piao, Ziyu Xun, Yunchao Wang, Cong Ning, Xinmu Zhang, Longhao Zhang, Yanyu Wang, Shanshan Wang, Jiashuo Chao, Zhenhui Lu, Xiaobo Yang, Hanping Wang, Haitao Zhao
Systemic therapies using programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors have demonstrated commendable efficacy in some patients with advanced hepatocellular carcinoma (HCC); however, other individuals do not respond favorably. Hence, identifying the biomarkers, the prognostic factors, and their underlying mechanisms is crucial. In this review, we summarized the latest advancements
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DeepMPTB: a vaginal microbiome-based deep neural network as artificial intelligence strategy for efficient preterm birth prediction Biomark. Res. (IF 11.1) Pub Date : 2024-02-14 Oshma Chakoory, Vincent Barra, Emmanuelle Rochette, Loïc Blanchon, Vincent Sapin, Etienne Merlin, Maguelonne Pons, Denis Gallot, Sophie Comtet-Marre, Pierre Peyret
In recent decades, preterm birth (PTB) has become a significant research focus in the healthcare field, as it is a leading cause of neonatal mortality worldwide. Using five independent study cohorts including 1290 vaginal samples from 561 pregnant women who delivered at term (n = 1029) or prematurely (n = 261), we analysed vaginal metagenomics data for precise microbiome structure characterization
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Oncogenic alterations in advanced NSCLC: a molecular super-highway Biomark. Res. (IF 11.1) Pub Date : 2024-02-12 Alex Friedlaender, Maurice Perol, Giuseppe Luigi Banna, Kaushal Parikh, Alfredo Addeo
Lung cancer ranks among the most common cancers world-wide and is the first cancer-related cause of death. The classification of lung cancer has evolved tremendously over the past two decades. Today, non-small cell lung cancer (NSCLC), particularly lung adenocarcinoma, comprises a multitude of molecular oncogenic subsets that change both the prognosis and management of disease. Since the first targeted
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Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy Biomark. Res. (IF 11.1) Pub Date : 2024-02-12 Szu-Ying Ho, Chih-Chin Kao, Che-Mai Chang, Yi-Chien Chou, Wei-Tzu Luo, Wan-Hsuan Chou, I-Lin Tsai, Mai-Szu Wu, Wei-Chiao Chang
Immunoglobulin A nephropathy (IgAN) is an autoimmune disease characterized by abnormal IgA deposition in glomerulus. Current diagnosis of IgAN still depends on renal biopsy, an invasive method that might increase the risk of clinical outcomes. Therefore, we aimed to explore the characteristics of T cell repertoire in IgAN from peripheral blood samples for identifying innovative diagnostic biomarkers
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Association between circulating ECM-associated molecules and cardiovascular outcomes in hemodialysis patients: a multicenter prospective cohort study Biomark. Res. (IF 11.1) Pub Date : 2024-02-08 Hyeon Seok Hwang, Jihyun Baek, So-Young Lee, Hye Yun Jeong, Jin Sug Kim, Yang Gyun Kim, ShinYoung Ahn, Kipyo Kim, Seok Hui Kang, Min-Jeong Lee, Dong-Young Lee, Yu Ho Lee
Hemodialysis patients are susceptible to cardiovascular remodeling, which increases the risk of cardiovascular morbidity and mortality. Circulating extracellular matrix (ECM)-associated molecules increase during cardiovascular remodeling and can be potential biomarkers of adverse cardiovascular outcomes. However, their clinical significance in patients undergoing hemodialysis remain unclear. This study
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Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy Biomark. Res. (IF 11.1) Pub Date : 2024-02-07 Dian Hu, Zerui Zhang, Xiangyuan Luo, Siwen Li, Junqing Jiang, Jiaqian Zhang, Zhangfan Wu, Yijun Wang, Mengyu Sun, Xiaoping Chen, Bixiang Zhang, Xiao Xu, Shuai Wang, Shengjun Xu, Yufei Wang, Wenjie Huang, Limin Xia
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap ‘n’ Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates epigenetic modifications, heme homeostasis, and oxidative stress. Additionally, it is involved in immune system development. More importantly, BACH1 is highly expressed in and plays a key role in
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A patient with multiple primary malignant neoplasms with high variant allele frequencies of RB1, TP53, and TERT Biomark. Res. (IF 11.1) Pub Date : 2024-02-06 Mingyang Ma, Kun Shang, Jiewei Wang, Xiaojing Teng, Peng Li, Jing Wang
Multiple primary malignant neoplasms are a rare disease with tumors of different histology or morphology arising in various sites. Next-generation sequencing is essential in the etiology, diagnosis, treatment, and surveillance of this disease. No eight primary malignant neoplasm cases with high variant allele frequencies of RB1, TP53, and TERT have been reported. Herein, we report a 65-year-old male
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LINC01559 promotes lung adenocarcinoma metastasis by disrupting the ubiquitination of vimentin Biomark. Res. (IF 11.1) Pub Date : 2024-02-05 Hao Feng, Dengfei Xu, Chenyang Jiang, Yuming Chen, Junru Wang, Zirui Ren, Xiang Li, Xu Dong Zhang, Shundong Cang
Distant metastasis is the major cause of lung adenocarcinoma (LUAD)-associated mortality. However, molecular mechanisms involved in LUAD metastasis remain to be fully understood. While the role of long non-coding RNAs (lncRNAs) in cancer development, progression, and treatment resistance is being increasingly appreciated, the list of dysregulated lncRNAs that contribute to LUAD pathogenesis is also
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Role of HOXA1-4 in the development of genetic and malignant diseases Biomark. Res. (IF 11.1) Pub Date : 2024-02-05 Lumin Wang, Haifeng Sun, Li Cao, Jinhai Wang
The HOXA genes, belonging to the HOX family, encompass 11 members (HOXA1-11) and exert critical functions in early embryonic development, as well as various adult processes. Furthermore, dysregulation of HOXA genes is implicated in genetic diseases, heart disease, and various cancers. In this comprehensive overview, we primarily focused on the HOXA1-4 genes and their associated functions and diseases
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MiRNAs as potential therapeutic targets and biomarkers for non-traumatic intracerebral hemorrhage Biomark. Res. (IF 11.1) Pub Date : 2024-02-02 Ilgiz Gareev, Ozal Beylerli, Boxian Zhao
Non-traumatic intracerebral hemorrhage (ICH) is the most common type of hemorrhagic stroke, most often occurring between the ages of 45 and 60. Hypertension is most often the cause of ICH. Less often, atherosclerosis, blood diseases, inflammatory changes in cerebral vessels, intoxication, vitamin deficiencies, and other reasons cause hemorrhages. Cerebral hemorrhage can occur by diapedesis or as a
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HER2-targeted therapies in cancer: a systematic review Biomark. Res. (IF 11.1) Pub Date : 2024-02-02 Kunrui Zhu, Xinyi Yang, Hebei Tai, Xiaorong Zhong, Ting Luo, Hong Zheng
Abnormal alterations in human epidermal growth factor receptor 2 (HER2, neu, and erbB2) are associated with the development of many tumors. It is currently a crucial treatment for multiple cancers. Advanced in molecular biology and further exploration of the HER2-mediated pathway have promoted the development of medicine design and combination drug regimens. An increasing number of HER2-targeted drugs
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Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells Biomark. Res. (IF 11.1) Pub Date : 2024-02-01 Elena Garcia-Borja, Frantisek Siegl, Rosana Mateu, Ondrej Slaby, Aleksi Sedo, Petr Busek, Jiri Sana
Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elements. However, several studies have suggested a role for the piRNA-PIWI axis in somatic cells, including somatic
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MRI-derived radiomics assessing tumor-infiltrating macrophages enable prediction of immune-phenotype, immunotherapy response and survival in glioma Biomark. Res. (IF 11.1) Pub Date : 2024-01-31 Di Chen, Rui Zhang, Xiaoming Huang, Chunxia Ji, Wei Xia, Ying Qi, Xinyu Yang, Lishuang Lin, Jing Wang, Haixia Cheng, Weijun Tang, Jinhua Yu, Dave S. B. Hoon, Jun Zhang, Xin Gao, Yu Yao
The tumor immune microenvironment can influence the prognosis and treatment response to immunotherapy. We aimed to develop a non-invasive radiomic signature in high-grade glioma (HGG) to predict the absolute density of tumor-associated macrophages (TAMs), the preponderant immune cells in the microenvironment of HGG. We also aimed to evaluate the association between the signature, and tumor immune phenotype
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Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling Biomark. Res. (IF 11.1) Pub Date : 2024-01-25 Ximin Tan, Deguang Kong, Zhuoli Tao, Fangling Cheng, Baoyuan Zhang, Zaiqi Wang, Qi Mei, Chuang Chen, Kongming Wu
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with crizotinib has shown promise, resistance remains a limitation. Recent evidence links focal adhesion kinase (FAK) to drug resistance, prompting our study to assess the combined impact of FAK inhibitor
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Exploring non-invasive precision treatment in non-small cell lung cancer patients through deep learning radiomics across imaging features and molecular phenotypes Biomark. Res. (IF 11.1) Pub Date : 2024-01-25 Xingping Zhang, Guijuan Zhang, Xingting Qiu, Jiao Yin, Wenjun Tan, Xiaoxia Yin, Hong Yang, Hua Wang, Yanchun Zhang
Accurate prediction of tumor molecular alterations is vital for optimizing cancer treatment. Traditional tissue-based approaches encounter limitations due to invasiveness, heterogeneity, and molecular dynamic changes. We aim to develop and validate a deep learning radiomics framework to obtain imaging features that reflect various molecular changes, aiding first-line treatment decisions for cancer
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Ribosome profiling: a powerful tool in oncological research Biomark. Res. (IF 11.1) Pub Date : 2024-01-25 Dan Su, Chen Ding, Jiangdong Qiu, Gang Yang, Ruobing Wang, Yueze Liu, Jinxin Tao, Wenhao Luo, Guihu Weng, Taiping Zhang
Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an essential part of gene expression, is dysregulated in cancer. The emergence of distinct translatomic technologies has revolutionized oncological studies to elucidate translational regulatory mechanisms. Ribosome profiling can
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Proteomics to predict relapse in patients with myelodysplastic neoplasms undergoing allogeneic hematopoietic cell transplantation Biomark. Res. (IF 11.1) Pub Date : 2024-01-25 Guru Subramanian Guru Murthy, Tao Zhang, Yung-Tsi Bolon, Stephen Spellman, Jing Dong, Paul Auer, Wael Saber
Disease relapse remains a major barrier to success after allogeneic hematopoietic cell transplantation (allo-HCT) in myelodysplastic neoplasms (MDS). While certain high risk genomic alterations are associated with increased risk of relapse, there is a lack of clinically applicable tools to analyze the downstream cellular events that are associated with relapse. We hypothesized that unique proteomic
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Dual roles of BK Polyomavirus in promoting urothelial carcinoma progression via regulating CLDN1 Biomark. Res. (IF 11.1) Pub Date : 2024-01-20 Cuidi Xu, Siyue Chen, Juntao Chen, Jina Wang, Xinhao Niu, Ruiming Rong, Tongyu Zhu, Yigang Zeng
Uncontrolled productive infection of BK polyomaviruses (BKV) in immunocompromised patients was reported to result in serious diseases, especially renourinary malignancies. However, the mechanism of BKV as a role of human carcinogen is still unknown. In this study, we showed that there is a significant association between BKV infection and metastasis of urothelial carcinoma (UCA). BKV-infected tumor
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BTLA biology in cancer: from bench discoveries to clinical potentials Biomark. Res. (IF 11.1) Pub Date : 2024-01-17 Anna Andrzejczak, Lidia Karabon
Immune checkpoints play a critical role in maintaining the delicate balance of immune activation in order to prevent potential harm caused by excessive activation, autoimmunity, or tissue damage. B and T lymphocyte attenuator (BTLA) is one of crucial checkpoint, regulating stimulatory and inhibitory signals in immune responses. Its interaction with the herpes virus entry mediator (HVEM) plays an essential
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Targeting TIGIT for cancer immunotherapy: recent advances and future directions Biomark. Res. (IF 11.1) Pub Date : 2024-01-16 Peng Zhang, Xinyuan Liu, Zhuoyu Gu, Zhongxing Jiang, Song Zhao, Yongping Song, Jifeng Yu
As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif (ITIM) domain (TIGIT) is highly expressed on CD4+ T cells, CD8+ T cells, natural killer (NK) cells, regulatory T cells (Tregs), and tumor-infiltrating lymphocytes (TILs). TIGIT has been associated with NK cell exhaustion in vivo and in individuals with various cancers. It not only modulates
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Phenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis Biomark. Res. (IF 11.1) Pub Date : 2024-01-09 Cian-Ru Yang, Wen-Jen Lin, Pei-Chun Shen, Pei-Yin Liao, Yuan-Chang Dai, Yao-Ching Hung, Hsueh‐Chou Lai, Shiraz Mehmood, Wei-Chung Cheng, Wen-Lung Ma
Metabolic associated steatohepatitis (MASH) is metabolic disease that may progress to cirrhosis and hepatocellular carcinoma. Mouse models of diet-induced MASH, which is characterized by the high levels of fats, sugars, and cholesterol in diets, are commonly used in research. However, mouse models accurately reflecting the progression of MASH in humans remain to be established. Studies have explored
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Deciphering the role of neddylation in tumor microenvironment modulation: common outcome of multiple signaling pathways Biomark. Res. (IF 11.1) Pub Date : 2024-01-08 Dequan Liu, Xiangyu Che, Guangzhen Wu
Neddylation is a post-translational modification process, similar to ubiquitination, that controls several biological processes. Notably, it is often aberrantly activated in neoplasms and plays a critical role in the intricate dynamics of the tumor microenvironment (TME). This regulatory influence of neddylation permeates extensively and profoundly within the TME, affecting the behavior of tumor cells
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Long-read transcriptome landscapes of primary and metastatic liver cancers at transcript resolution Biomark. Res. (IF 11.1) Pub Date : 2024-01-08 Zhiao Chen, Qili Shi, Yiming Zhao, Midie Xu, Yizhe Liu, Xinrong Li, Li Liu, Menghong Sun, Xiaohua Wu, Zhimin Shao, Ye Xu, Lu Wang, Xianghuo He
The liver ranks as the sixth most prevalent site of primary cancer in humans, and it frequently experiences metastases from cancers originating in other organs. To facilitate the development of effective treatments and improve survival rates, it is crucial to comprehend the intricate and diverse transcriptome landscape of primary and metastatic liver cancers. We conducted long-read isoform sequencing
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Deciphering the correlation between metabolic activity through 18F-FDG-PET/CT and immune landscape in soft-tissue sarcomas: an insight from the NEOSARCOMICS study Biomark. Res. (IF 11.1) Pub Date : 2024-01-07 Amandine Crombé, Frédéric Bertolo, Lucile Vanhersecke, Jean-Philippe Guegan, Alban Bessede, Raul Perret, François Le Loarer, Vanessa Chaire, Jean-Michel Coindre, Carlo Lucchesi, Antoine Italiano
Metabolic elevation in soft-tissue sarcomas (STS), as documented with 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET/CT) has been linked with cell proliferation, higher grade, and lower survivals. However, the recent diagnostic innovations (CINSARC gene-expression signature and tertiary lymphoid structure [TLS]) and therapeutic innovations (immune checkpoint inhibitors [ICIs]) for
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Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy Biomark. Res. (IF 11.1) Pub Date : 2024-01-07 Xi Chen, Zhijie Xu, Tongfei Li, Abhimanyu Thakur, Yu Wen, Kui Zhang, Yuanhong Liu, Qiuju Liang, Wangrui Liu, Jiang-Jiang Qin, Yuanliang Yan
The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor immunity through immune effector responses. Targeting the cGAS-STING pathway holds promise for overcoming immunosuppressive tumor microenvironments (TME) and promoting effective tumor elimination. However, systemic administration of current STING agonists faces
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Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities Biomark. Res. (IF 11.1) Pub Date : 2024-01-07 Yujing Qian, Yujia Yin, Xiaocui Zheng, Zhaoyuan Liu, Xipeng Wang
Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse functions in tumors. Their identity is determined not only by intrinsic factors, such as origins and transcription factors, but also by external signals from the tumor microenvironment (TME), such as inflammatory signals and metabolic reprogramming. Metabolic reprogramming has rendered TAM to exhibit a spectrum of
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S100A8/A9 as a risk factor for breast cancer negatively regulated by DACH1 Biomark. Res. (IF 11.1) Pub Date : 2023-12-13 Xiaojun Zhang, Mengke Niu, Tianye Li, Yuze Wu, Jinnan Gao, Ming Yi, Kongming Wu
S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting as antibacterial cytokines, S100A8/A9 is also associated with metabolic and autoimmune diseases such as obesity, diabetes, and rheumatoid arthritis. While the involvement of S100A8/A9 in breast
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Repressing HIF-1α-induced HDAC9 contributes to the synergistic effect of venetoclax and MENIN inhibitor in KMT2Ar AML Biomark. Res. (IF 11.1) Pub Date : 2023-12-05 Qing Ling, Yutong Zhou, Yu Qian, Jiejing Qian, Yi Zhang, Jinghan Wang, Yanan Zhu, Yile Zhou, Juying Wei, Chunmei Yang, Jie Sun, Wenjuan Yu, Jie Jin, Xiang Zhang
KMT2A-rearranged acute myeloid leukemia (KMT2Ar-AML) is an aggressive subtype of AML with poor response and prognosis. KMT2Ar-AML has been demonstrated to be sensitive to BCL2 inhibitor venetoclax (VEN), but these patients are unable to benefit from current VEN-based regimen (VEN plus azacitidine or low dose-cytarabine), so a novel and KMT2A rearrangement-specific targeting partner is required, and
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Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges Biomark. Res. (IF 11.1) Pub Date : 2023-12-01 Zhi Pang, Man-man Lu, Yu Zhang, Yuan Gao, Jin-jin Bai, Jian-ying Gu, Lu Xie, Wei-zhong Wu
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed with an incredible diversity of T cell receptors (TCRs) that theoretically react to the variety of random mutations generated by tumor cells. The outcomes, however, of current clinical trials
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The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors Biomark. Res. (IF 11.1) Pub Date : 2023-11-28 Kaveh Hadiloo, Siavash Taremi, Mahmood Heidari, Abdolreza Esmaeilzadeh
Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA-approved drugs, could treat several types of hematological malignancies and thus be very attractive for treating solid cancer. Unfortunately, the CAR T cell cannot be very functional in solid cancers due to its unique features
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Improving the prediction of Spreading Through Air Spaces (STAS) in primary lung cancer with a dynamic dual-delta hybrid machine learning model: a multicenter cohort study Biomark. Res. (IF 11.1) Pub Date : 2023-11-23 Weiqiu Jin, Leilei Shen, Yu Tian, Hongda Zhu, Ningyuan Zou, Mengwei Zhang, Qian Chen, Changzi Dong, Qisheng Yang, Long Jiang, Jia Huang, Zheng Yuan, Xiaodan Ye, Qingquan Luo
Reliable pre-surgical prediction of spreading through air spaces (STAS) in primary lung cancer is essential for precision treatment and surgical decision-making. We aimed to develop and validate a dual-delta deep-learning and radiomics model based on pretreatment computed tomography (CT) image series to predict the STAS in patients with lung cancer. Six hundred seventy-four patients with pre-surgery
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Correction: Exploring the feasibility of using long-term stored newborn dried blood spots to identify metabolic features for congenital heart disease screening Biomark. Res. (IF 11.1) Pub Date : 2023-11-22 Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G. Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian, Harvey J. Cohen, Doff B. McElhinney
Biomarker Research (2023) 11:97 https://doi.org/10.1186/s40364-023-00536-y The original article [1] contained an error in the affiliations of co-authors, Yaqi Zhang and Xuefeng B. Ling due to a no-fault misinterpretation during the proofing process. The affiliations have since been amended to reflect the affiliations that were originally requested by the authors. Authors and Affiliations Department
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Exosome derived from tumor-associated macrophages: biogenesis, functions, and therapeutic implications in human cancers Biomark. Res. (IF 11.1) Pub Date : 2023-11-19 Manli Zhou, Xiaoyun He, Cheng Mei, Chunlin Ou
Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in the tumor microenvironment (TME), account for approximately 50% of the local hematopoietic cells. TAMs play an important role in tumorigenesis and tumor development through crosstalk between various immune cells and cytokines in the TME. Exosomes are small extracellular vesicles with a diameter of 50–150 nm, that can
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Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology Biomark. Res. (IF 11.1) Pub Date : 2023-11-17 Karama Asleh, Valerie Dery, Catherine Taylor, Michelle Davey, Marie-Ange Djeungoue-Petga, Rodney J. Ouellette
While the field of precision oncology is rapidly expanding and more targeted options are revolutionizing cancer treatment paradigms, therapeutic resistance particularly to immunotherapy remains a pressing challenge. This can be largely attributed to the dynamic tumor-stroma interactions that continuously alter the microenvironment. While to date most advancements have been made through examining the
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Baseline extracellular vesicle miRNA-30c and autophagic CTCs predict chemoradiotherapy resistance and outcomes in patients with lung cancer Biomark. Res. (IF 11.1) Pub Date : 2023-11-15 Diego de Miguel-Perez, Francisco Gabriel Ortega, Rosario Guerrero Tejada, Antonio Martínez-Única, Christine B. Peterson, Alessandro Russo, Muthukumar Gunasekaran, Andres F. Cardona, Victor Amezcua, Jose Antonio Lorente, Jose Expósito Hernández, Christian Rolfo, Maria Jose Serrano
Concurrent chemoradiotherapy (cCRT) is the mainstay of treatment for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC). One significant challenge in the effectiveness of this therapy is the potential development of resistance mechanisms, where autophagy up-regulation has been proposed as a key contributing factor. However, there is a lack of reliable biomarkers to predict
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Exploring the feasibility of using long-term stored newborn dried blood spots to identify metabolic features for congenital heart disease screening Biomark. Res. (IF 11.1) Pub Date : 2023-11-13 Scott R. Ceresnak, Yaqi Zhang, Xuefeng B. Ling, Kuo Jung Su, Qiming Tang, Bo Jin, James Schilling, C. James Chou, Zhi Han, Brendan J. Floyd, John C. Whitin, Kuo Yuan Hwa, Karl G Sylvester, Henry Chubb, Ruben Y. Luo, Lu Tian, Harvey J. Cohen, Doff B. McElhinney
Congenital heart disease (CHD) represents a significant contributor to both morbidity and mortality in neonates and children. There’s currently no analogous dried blood spot (DBS) screening for CHD immediately after birth. This study was set to assess the feasibility of using DBS to identify reliable metabolite biomarkers with clinical relevance, with the aim to screen and classify CHD utilizing the
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Correction: Multi-faceted attributes of salivary cell-free DNA as liquid biopsy biomarkers for gastric cancer detection Biomark. Res. (IF 11.1) Pub Date : 2023-11-09 Neeti Swarup, Jordan Cheng, Irene Choi, You Jeong Heo, Misagh Kordi, Mohammad Aziz, Akanksha Arora, Feng Li, David Chia, Fang Wei, David Elashoff, Liying Zhang, Sung Kim, Yong Kim, David T.W. Wong
Biomarker Research (2023) 11:90 https://doi.org/10.1186/s40364-023-00524-2 The original article [1] contains errors in the attributions for the following co-authors: David Chia, David Elashoff, Liying Zhang, and Sung Kim. The corrected affiliations can be viewed in the authorship list of this Correction article.Author notes Neeti Swarup and Jordan Cheng contributed equally. Authors and Affiliations
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Correction: Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer Biomark. Res. (IF 11.1) Pub Date : 2023-11-09 Jie Mei, Leiyu Hao, Xiaorui Liu, Guangshun Sun, Rui Xu, Huiyu Wang, Chaoying Liu
Correction: Biomark Res 7, 16 (2019) https://doi.org/10.1186/s40364-019-0168-9 The original article [1] contains the following errors: 1) The ordinate scale is displayed incorrectly in Fig. 2D-F. 2) Fig. 3E was duplicated over Fig. 3F. 3) Table 3 contained data in the ‘HR’, ‘95% CI’, and ‘P-value’ columns of the ‘Adjuvant chemotherapy’ and ‘Non-chemotherapy’ rows that should have been deleted. Fig
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MiR-151a: a robust endogenous control for normalizing small extracellular vesicle cargo in human cancer Biomark. Res. (IF 11.1) Pub Date : 2023-10-20 Miranda Burdiel, Julia Jiménez, Carlos Rodríguez-Antolín, Álvaro García-Guede, Olga Pernía, Ana Sastre-Perona, Rocío Rosas-Alonso, Julián Colmenarejo, Carmen Rodríguez-Jiménez, María Dolores Diestro, Virginia Martínez-Marín, Oliver Higueras, Patricia Cruz, Itsaso Losantos-García, Héctor Peinado, Olga Vera, Javier de Castro, Inmaculada Ibáñez de Cáceres
Small extracellular vesicles (sEVs) in the blood of cancer patients contain higher amounts of tumor markers than those identified as free-circulating. miRNAs have significant biomedical relevance due to their high stability and feasible detection. However, there is no reliable endogenous control available to measure sEVs-miRNA content, impairing the acquisition of standardized consistent measurements
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Circulating Tumor DNA from Ascites as an alternative to tumor sampling for genomic profiling in ovarian cancer patients Biomark. Res. (IF 11.1) Pub Date : 2023-10-20 Maria Kfoury, Reda El Hazzaz, Claire Sanson, Felix Blanc Durand, Judith Michels, Emeline Colomba Blameble, Roseline Tang, Audrey Le Formal, Elodie Lecerf, Sebastien Gouy, Amandine Maulard, Patricia Pautier, Etienne Rouleau, Alexandra Leary
Genomic testing is crucial for the management of ovarian cancer. DNA from biopsies at diagnostic laparoscopies or interval debulking surgery after neoadjuvant chemotherapy, has a high failure rate. At relapse, biopsies may not be feasible. The aim of our study was to evaluate the feasibility and usefulness of measuring genomic instability score (GIS) on cell-free DNA (cfDNA) from ascites. Patients
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A functional role of Ephrin type-B receptor 6 (EPHB6) in T-cell acute lymphoblastic leukemia Biomark. Res. (IF 11.1) Pub Date : 2023-10-20 Mattia Colucci, Nadia Trivieri, Gandino Mencarelli, Elisabetta De Santis, Francesca Sansico, Francesco Tamiro, Alberto Visioli, Chiara Barile, Riccardo Pracella, Giovanni Rossi, Elena Binda, Vincenzo Giambra
T-cell lymphoblastic acute leukemia (T-ALL) is an aggressive blood cancer, characterized by restricted cellular subsets with enriched leukemia initiating cells (LICs). Recently, Ephrin receptors (Eph) were described to be highly expressed in cancer stem cells. Here, using public RNA-Seq datasets of human T-ALL, we reported that EphB6 was the only member within the Eph family overexpressed in over 260
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First third-generation CAR T cell application targeting CD19 for the treatment of systemic IgM AL amyloidosis with underlying marginal zone lymphoma Biomark. Res. (IF 11.1) Pub Date : 2023-10-14 Felix Korell, Stefan Schönland, Anita Schmitt, Madelaine Jansen, Kiavasch Farid, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Ute Hegenbart
Light chain amyloidosis (AL) is a rare disease caused by the generalized deposition of misfolded free light chains. Patients with immunoglobulin M gammopathy (IgM) and indolent B-cell lymphoma such as marginal zone lymphoma (MZL) may in some instances develop AL amyloidosis. So far, CAR T cells for AL amyloidosis have only been reported utilizing the B cell maturation antigen as target, while CD19
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Multi-faceted attributes of salivary cell-free DNA as liquid biopsy biomarkers for gastric cancer detection Biomark. Res. (IF 11.1) Pub Date : 2023-10-10 Neeti Swarup, Jordan Cheng, Irene Choi, You Jeong Heo, Misagh Kordi, Mohammad Aziz, Akanksha Arora, Feng Li, David Chia, Fang Wei, David Elashoff, Liying Zhang, Sung Kim, Yong Kim, David T.W. Wong
Recent advances in circulating cell-free DNA (cfDNA) analysis from biofluids have opened new avenues for liquid biopsy (LB). However, current cfDNA LB assays are limited by the availability of existing information on established genotypes associated with tumor tissues. Certain cancers present with a limited list of established mutated cfDNA biomarkers, and thus, nonmutated cfDNA characteristics along
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Mitochondrial transfer in hematological malignancies Biomark. Res. (IF 11.1) Pub Date : 2023-10-05 Xiaodong Guo, Can Can, Wancheng Liu, Yihong Wei, Xinyu Yang, Jinting Liu, Hexiao Jia, Wenbo Jia, Hanyang Wu, Daoxin Ma
Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondrial transfer improves mitochondrial defects, restores the biological functions of recipient cells, and maintains the high metabolic requirements of tumor cells as well as drug resistance. In recent
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Diagnosing and monitoring pancreatic cancer through cell-free DNA methylation: progress and prospects Biomark. Res. (IF 11.1) Pub Date : 2023-10-05 María Victoria García-Ortiz, Pablo Cano-Ramírez, Marta Toledano-Fonseca, Enrique Aranda, Antonio Rodríguez-Ariza
Pancreatic cancer is one of the most challenging cancers due to its high mortality rates. Considering the late diagnosis and the limited survival benefit with current treatment options, it becomes imperative to optimize early detection, prognosis and prediction of treatment response. To address these challenges, significant research efforts have been undertaken in recent years to develop liquid-biopsy-based
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A model based on adipose and muscle-related indicators evaluated by CT images for predicting microvascular invasion in HCC patients Biomark. Res. (IF 11.1) Pub Date : 2023-10-04 Xin-Cheng Mao, Shuo Shi, Lun-Jie Yan, Han-Chao Wang, Zi-Niu Ding, Hui Liu, Guo-Qiang Pan, Xiao Zhang, Cheng-Long Han, Bao-Wen Tian, Dong-Xu Wang, Si-Yu Tan, Zhao-Ru Dong, Yu-Chuan Yan, Tao Li
The presence of microvascular invasion (MVI) will impair the surgical outcome of hepatocellular carcinoma (HCC). Adipose and muscle tissues have been confirmed to be associated with the prognosis of HCC. We aimed to develop and validate a nomogram based on adipose and muscle related-variables for preoperative prediction of MVI in HCC. One hundred fifty-eight HCC patients from institution A (training
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Novel role of immune-related non-coding RNAs as potential biomarkers regulating tumour immunoresponse via MICA/NKG2D pathway Biomark. Res. (IF 11.1) Pub Date : 2023-10-02 Jing Zhang, Qizhi Luo, Xin Li, Junshuang Guo, Quan Zhu, Xiaofang Lu, Leiyan Wei, Zhiqing Xiang, Manqing Peng, Chunlin Ou, Yizhou Zou
Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D receptor (NKG2D) that is expressed in various tumour cells. Given that the MICA/NKG2D signalling system is critically embedded in the innate and adaptive immune responses, it is particularly involved in the surveillance of cancer and viral infections. Emerging
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Lectins as potential tools for cancer biomarker discovery from extracellular vesicles Biomark. Res. (IF 11.1) Pub Date : 2023-09-29 Md. Khirul Islam, Misba Khan, Kamlesh Gidwani, Kenneth W. Witwer, Urpo Lamminmäki, Janne Leivo
Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be used to “target” EVs to specific cells. Cancer is associated with alterations to cellular and EV glycosylation patterns, and the surface of EVs is enriched with glycan moieties. Glycoconjugates
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Survival of patients with transformed follicular lymphoma in the United States: a multiple cohort study Biomark. Res. (IF 11.1) Pub Date : 2023-09-27 John L. Vaughn, Narendranath Epperla
Population-based data comparing the outcomes of patients with transformed follicular lymphoma (t-FL) and de novo diffuse large B-cell lymphoma (DLBCL) are lacking. The objective of this study was to compare the survival of patients with t-FL and de novo DLBCL diagnosed in the United States between 2010–2018. We hypothesized that patients with t-FL would have an inferior survival compared to patients
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singleCellBase: a high-quality manually curated database of cell markers for single cell annotation across multiple species Biomark. Res. (IF 11.1) Pub Date : 2023-09-20 Fan-Lin Meng, Xiao-Ling Huang, Wen-Yan Qin, Kun-Bang Liu, Yan Wang, Ming Li, Yong-Hong Ren, Yan-Ze Li, Yi-Min Sun
Annotating cells in the analysis of single-cell RNA-seq (scRNA-seq) data is one of the most challenging tasks that researchers are actively addressing. Manual cell annotation is generally considered the gold standard method, although it is labor intensive and independent of prior knowledge. At present, the relationship between high-quality, known marker genes and cell types is very limited, especially
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Circulating cell-free DNA (cfDNA) in patients with medullary thyroid carcinoma is characterized by specific fragmentation and methylation changes with diagnostic value Biomark. Res. (IF 11.1) Pub Date : 2023-09-19 Anna Citarella, Zein Mersini Besharat, Sofia Trocchianesi, Tanja Milena Autilio, Antonella Verrienti, Giuseppina Catanzaro, Elena Splendiani, Zaira Spinello, Silvia Cantara, Patrizia Zavattari, Eleonora Loi, Cristina Romei, Raffaele Ciampi, Luciano Pezzullo, Maria Grazia Castagna, Antonio Angeloni, Rosella Elisei, Cosimo Durante, Agnese Po, Elisabetta Ferretti
Medullary Thyroid Carcinoma (MTC) is a rare neuroendocrine tumour whose diagnosis includes evaluating calcitonin serum levels, which can present fluctuations unrelated to MTC. Here, we investigated circulating DNA fragmentation and methylation changes as potential biomarkers using ddPCR on cell-free DNA (cfDNA) isolated from the plasma of MTC patients. For cfDNA fragmentation analysis, we investigated
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The clinical application of ctDNA to predict response to neoadjuvant chemoradiotherapy in patients with locally-advanced rectal cancer Biomark. Res. (IF 11.1) Pub Date : 2023-09-19 Parmida Sadat Pezeshki, Reza Ghalehtaki
Colorectal cancer is a major cause of cancer-related deaths worldwide. A third of colorectal cancers reside in the rectum. Many patients with rectal cancer present in the locally-advanced stage which needs multi-modality therapy usually starting with neoadjuvant chemo-radiotherapy followed by surgery and adjuvant systemic chemotherapy. Total neoadjuvant therapy, defined as the preoperative administration