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Constrained polynomial fit-based k-domain interpolation in swept-source optical coherence tomography J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2021-01-13 Tao Han; Jianrong Qiu; Di Wang; Jia Meng; Zhiyi Liu; Zhihua Ding
We propose a k-domain spline interpolation method with constrained polynomial fit based on spectral phase in swept-source optical coherence tomography (SS-OCT). A Mach–Zehnder interferometer (MZI) unit is connected to the swept-source of the SS-OCT system to generate calibration signal in sync with the fetching of interference spectra. The spectral phase of the calibration signal is extracted by Hilbert
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The biostimulative effectiveness of photobiomodulation therapy application on thawed dental pulp stem cells J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2021-01-11 Cenk Serhan Özverel; Aylin İslam; Hasan Güney Yılmaz
This study was conducted to understand the cellular proliferative effect of Photobiomodulation Therapy (PBMT) on thawed dental pulp stem cells (DPSCs) stored for 2 years. For this purpose, cells were exposed to PBMT for short period of time to evaluate the most appropriate PBMT parameter for stimulating cellular proliferation that can be used for future tissue engineering therapies. Fully characterized
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Research on optical properties of cardiovascular tissues based on OCT data J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2021-01-09 Na Qin; Yana Liu; Lin Huang; Yi Xin; Xiao Zhang; Xiaoming Hu; Qin Li
As a high-resolution optical imaging technology, Optical Coherence Tomography (OCT) has been widely used in the diagnosis and treatment of cardiovascular diseases. It has played an important role in the detection and identification of atherosclerotic plaques and has significant advantages. In this paper, we realized to extract the optical characteristic parameters of the target sample based on the
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Monitoring of edema progression in permanent and transient MCAO model using SS-OCT J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2021-01-04 Yao Yu; Ziyue Meng; Ang Li; Yang Lin; Jian Liu; Yushu Ma; Yi Wang; Zhenhe Ma
Cerebral edema is a severe complication of acute ischemic stroke with high mortality but limited treatment. Although parameters such as brain water content and intracranial pressure may represent the global assessment of edema, optical properties can appear heterogeneously throughout the cerebral tissue relative to the site of injury. In this study, we have monitored the edema formation and progression
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Determination of diffusion coefficient by image-based fluorescence recovery after photobleaching and single particle tracking system implemented in a single platform J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-30 Donghee Lee; Jeonghoon Lee; Jung Kyung Kim
Fluorescence recovery after photobleaching (FRAP) and single particle tracking (SPT) techniques determine the diffusion coefficient from average diffusive motion of high-concentration molecules and from trajectories of low-concentration single molecules, respectively. Lateral diffusion coefficients measured by FRAP and SPT techniques for the same biomolecule on cell membrane have exhibited inconsistent
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Deep learning algorithms to segment and quantify the choroidal thickness and vasculature in swept-source optical coherence tomography images J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-23 Gu Zheng; Yanfeng Jiang; Ce Shi; Hanpei Miao; Xiangle Yu; Yiyi Wang; Sisi Chen; Zhiyang Lin; Weicheng Wang; Fan Lu; Meixiao Shen
Accurate segmentation of choroidal thickness (CT) and vasculature is important to better analyze and understand the choroid-related ocular diseases. In this paper, we proposed and implemented a novel and practical method based on the deep learning algorithms, residual U-Net, to segment and quantify the CT and vasculature automatically. With limited training data and validation data, the residual U-Net
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Development of a hydrogen peroxide-responsive and oxygen-carrying nanoemulsion for photodynamic therapy against hypoxic tumors using phase inversion composition method J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-23 Liang Hong; Jia Zhang; Junxian Geng; Junle Qu; Liwei Liu
Photodynamic therapy (PDT) has become an attractive tumor treatment modality because of its noninvasive feature and low side effects. However, extreme hypoxia inside solid tumors severely impedes PDT therapeutic outcome. To overcome this obstacle, various strategies have been developed recently. Among them, in situ oxygen generation, which relies on the decomposition of tumor endogenous H2O2, and oxygen
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A measurement of epidermal thickness of fingertip skin from OCT images using convolutional neural network J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-21 Yongping Lin; Dezi Li; Wang Liu; Zhaowei Zhong; Zhifang Li; Youwu He; Shulian Wu
In this study, we proposed a method to measure the epidermal thickness (ET) of skin based on deep convolutional neural network, which was used to determine the boundaries of skin surface and the ridge portion in dermal–epidermis junction (DEJ) in cross-section optical coherence tomography (OCT) images of fingertip skin. The ET was calculated based on the row difference between the surface and the ridge
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Corneal damage effects induced by infrared optical parametric oscillator radiation at 3743 nm J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-21 Luguang Jiao; Chao Wang; Kaizeng Zhang; Jiarui Wang; Zaifu Yang
The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator (OPO) radiation. Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743nm for exposure durations of 0.1s, 1.0s and 10.0s. Through slit-lamp biomicroscope and histopathology, corneal injury characteristics were
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Identification of oral squamous cell carcinoma in optical coherence tomography images based on texture features J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-16 Zihan Yang; Jianwei Shang; Chenlu Liu; Jun Zhang; Yanmei Liang
Surgical excision is an effective treatment for oral squamous cell carcinoma (OSCC), but exact intraoperative differentiation OSCC from the normal tissue is the first premise. As a noninvasive imaging technique, optical coherence tomography (OCT) has the nearly same resolution as the histopathological examination, whose images contain rich information to assist surgeons to make clinical decisions.
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A method of removing retardance induced by scattering of collagenous fiber bundles J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-16 Wanrong Gao; Siyu Liu
In this work, we report a method of removing scattering induced retardance in polarization sensitive full field optical coherence tomography (PS-FFOCT). First, the Mueller matrix that describes its operation is derived. The thickness invariant retardance induced by the scattering of collagenous fiber bundles is then used to find the accurate values of the birefringence of the layers that consist collagenous
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Feasibility and utility of intraoperative optical coherence tomography during vitreoretinal surgery: A 4-year report in Chinese population J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-16 Jiwei Tao; Huan Chen; Jiafeng Yu; Dan Cheng; Yiqi Chen; Jianbo Mao; Jia Fang; Lijun Shen
Purpose: To introduce the application of intraoperative optical coherence tomography (iOCT) in pars plana vitrectomy (PPV) for various vitreoretinal diseases, and to report the 4-year assessment of feasibility and utility in Chinese population. Methods: Retrospective case series of patients who underwent PPV and iOCT scan at Eye Hospital of Wenzhou Medical College from January 2016 to January 2020
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Inertial gradient method for fluorescence molecular tomography J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-12-09 Lei Wang; Hui Huang
Image reconstruction in fluorescence molecular tomography involves seeking stable and meaningful solutions via the inversion of a highly under-determined and severely ill-posed linear mapping. An attractive scheme consists of minimizing a convex objective function that includes a quadratic error term added to a convex and nonsmooth sparsity-promoting regularizer. Choosing ℓ1-norm as a particular case
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Stick-slip nonuniform rotation distortion correction in distal scanning optical coherence tomography catheters J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-10-28 Jessica Mavadia-Shukla; Jianlin Zhang; Kaiyan Li; Xingde Li
We present a robust and fiducial-marker-free algorithm that can identify and correct stick-slip distortion caused by nonuniform rotation (or beam scanning) in distally scanned catheters for endoscopic optical coherence tomography (OCT) images. This algorithm employs spatial frequency analysis to select and remove distortions. We demonstrate the feasibility of this algorithm on images acquired from
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Diffuse transmitted spectroscopy in conjunction with spectral peak averaging as a potential tool for noninvasive creatinine screening J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-10-01 Zvi Hai Barnea (Burbea); Shmuel Zimlichman; David Abookasis
Creatinine (Cr) is a biochemical waste molecule generated from muscle metabolism and primarily cleared from the bloodstream by the kidneys. If kidney function declines, Cr levels in the blood tend to increase. Therefore, Cr serves as an indicator of kidney function. In this work, we present a simple method for the rapid screening for impaired renal function based on the subject’s Cr concentration.
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Quantification of potassium concentration with Vis–SWNIR spectroscopy in fresh lettuce J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-10-28 Yating Xiong; Shintaroh Ohashi; Kazuhiro Nakano; Weizhong Jiang; Kenichi Takizawa; Kazuyuki Iijima; Phonkrit Maniwara
Chronic kidney disease (CKD) is becoming a major public health problem worldwide, and excessive potassium intake is a health threat to patients with CKD. In this study, visible–short-wave near-infrared (Vis–SWNIR) spectroscopy and chemometric algorithms were investigated as nondestructive methods for assessing the potassium concentration in fresh lettuce to benefit the CKD patients’ health. Interactance
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Assessment of myocardial viability using a minimally invasive laser Doppler flowmetry on pig model J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-10-28 Karina Litvinova; Berthold Stegemann; Francisco Leyva
Background: The intra-operative real-time assessment of tissue viability can potentially improve therapy delivery and clinical outcome in cardiovascular therapies. Cardiac ablation therapy for the treatment of supraventricular or ventricular arrhythmia continues to be done without being able to assess if the intended lesion and lesion size have been achieved. Here, we report a method for continuous
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Observations of intracellular second-harmonic generation imaging in black phosphorus nanosheets J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-10-21 Xiao Peng; Yiwan Song; Zheng Peng; Kaixuan Nie; Hao Liu; Yingxin Zhou; Feifan Zhou; Yufeng Yuan; Jun Song; Junle Qu
Functionalized black phosphorus (BP) nanosheets have been considered as promising nanoagents in cancer therapy due to their excellent photothermal conversion efficiency. However, it is still difficult to visually monitor the dynamic localization of BP nanoagents in cancer cells. In this paper, we systematically studied the second-harmonic generation (SHG) signals originating from exfoliated BP nanosheets
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Structured illumination microscopy based on asymmetric three-beam interference J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-10-17 Linyu Xu; Yanwei Zhang; Song Lang; Hongwei Wang; Huijie Hu; Jingkai Wang; Yan Gong
Structured illumination microscopy (SIM) is a rapidly developing super-resolution technology. It has been widely used in various application fields of biomedicine due to its excellent two- and three-dimensional imaging capabilities. Furthermore, faster three-dimensional imaging methods are required to help enable more research-oriented living cell imaging. In this paper, a fast and sensitive three-dimensional
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Applications of Raman spectroscopy in two-dimensional materials J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-08-18 Pengkun Yin; Qingyu Lin; Yixiang Duan
At present, two-dimensional (2D) materials have shown great application potential in numerous fields based on their physical chemical and electronic properties. Raman spectroscopy and derivative techniques are effective tools for characterizing 2D materials. Raman spectroscopy conveys lots of knowledge on 2D materials, including layer number, doping type, strain and interlayer coupling. This review
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Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-09-02 Zhimei Wei; Liqun Wang; Shouyu Zhang; Tonghai Chen; Jie Yang; Shengru Long; Xiaojun Wang
Bacterial infections are a major cause of chronic infections. Thus, antibacterial material is an urgent need in clinics. Antibacterial nanofibers, with expansive surface area, enable efficient incorporation of antibacterial agents. Meanwhile, structure similar to the extracellular matrix can accelerate cell growth. Electrospinning, the most widely used technique to fabricate nanofiber, is often used
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Synthesis of a dithieno[3,2-b:2′,3′-d]silole-based conjugated polymer and characterization of its short wave near-infrared fluorescence properties J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-09-03 Chuantao Gu; Chunying Zheng; Bing Liu; Tingyu Feng; Jiping Ma; Haofen Sun
Short wave near-infrared (SWIR, 900–1700nm) fluorescence imaging has attracted extensive research interest from scientists due to its high imaging quality. However, the variety of SWIR fluorescence imaging agents are quite limited and the corresponding quantum efficiency is relatively low. In this work, a novel conjugated polymer PDTSDTBT was reported, consisting of a donor unit with a tetrahedral
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The short wave near-infrared fluorescence properties of two p-azaquinodimethane (p-AQM)-based conjugated polymers J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-08-26 Yaowei Zhu; Yawei Miao; Tingting Xue; Youchang Liu; Chunying Zheng; Jiping Ma; Weiqiang Tan; Shuguang Wen; Chuantao Gu
The absorption, scattering, and autofluorescence of biological tissues in short-wave infrared region (SWIR, 900–1700nm) are relatively low, so SWIR fluorescence usually has deeper penetration into living tissues, and can show a higher signal-to-noise ratio when used for imaging in vivo. However, there are few types of organic SWIR fluorescent materials currently. In this work, p-azaquinodimethane (p-AQM)
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Rapid label-free SERS detection of foodborne pathogenic bacteria based on hafnium ditelluride-Au nanocomposites J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-09-25 Yang Li; Yanxian Guo; Binggang Ye; Zhengfei Zhuang; Peilin Lan; Yue Zhang; Huiqing Zhong; Hao Liu; Zhouyi Guo; Zhiming Liu
Two-dimensional (2D) nanomaterials have captured an increasing attention in biophotonics owing to their excellent optical features. Herein, 2D hafnium ditelluride (HfTe2), a new member of transition metal tellurides, is exploited to support gold nanoparticles fabricating HfTe2-Au nanocomposites. The nanohybrids can serve as novel 2D surface-enhanced Raman scattering (SERS) substrate for the label-free
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A miniaturized fluorescence imaging device for rapid early skin cancer detection J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-09-16 Jingyue Pan; Qingquan Liu; Hao Sun; Weibo Zheng; Peiru Wang; Long Wen; Junli Duan; Zhiyi Xuan; Xiang Yu; Shaowei Wang; Xiuli Wang; Tao Zhang; Wei Lu
Fluorescence imaging is very useful for skin cancer lesions detection because of its properties of noninvasion and fast imaging. However, conventional fluorescence imaging devices’ excitation light source and camera are usually separated, which will cause problems such as complicated structure, large volume, and poor illumination homogeneity. In this paper, we introduce a miniature portable fluorescence
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Effects of stimulating frequency of NIR LEDs light irradiation on forehead as quantified by EEG measurements J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-09-09 Liuye Yao; Zhiyu Qian; Yangyang Liu; Zhou Fang; Weitao Li; Lidong Xing
Near-infrared (NIR) light has been shown to produce a range of physiological effects in humans, however, there is still no agreement on whether and how a single parameter, like the flicker frequency of NIR light, affects the brain. Methods: An 810nm NIR LED was used as the stimulator. Fifty subjects participated in this experiment. Forty subjects were randomly divided into four groups. Each group underwent
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In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-08-28 Elena B. Kiseleva; Alexander A. Moiseev; Anton S. Kuyarov; Muhammat A. Molvi; Grigory V. Gelikonov; Anna V. Maslennikova; Olga S. Streltsova
The paper presents the results of a study of the female urethra in cases of urethral pain syndrome (UPS) and inflammatory diseases of the lower urinary tract using cross-polarization optical coherence tomography (CP OCT). Urethral wall structure was studied in 86 patients; 233 CP OCT images were collected. A comparative qualitative analysis of three groups of CP OCT images — “norm”, “Inflammation”
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Effect of antibacterial photodynamic therapy on Streptococcus mutans plaque biofilm in vitro J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-08-08 Xiaoyue Liang; Zhaohui Zou; Zheng Zou; Changyi Li; Xiaoxi Dong; Huijuan Yin; Guohui Yan
The main objective of this study is to evaluate the antibacterial effect of antibacterial photodynamic therapy (aPDT) on Streptococcus mutans (S. mutans) biofilm model in vitro. The selection of photosensitizers is the key step for the efficacy of photodynamic therapy (PDT). However, no studies have been conducted in the oral field to compare the functional characteristics and application effects of
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Application of digital micromirror devices (DMD) in biomedical instruments J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-08-05 Ziyun Zhuang; Ho Pui Ho
There is an ongoing technological revolution in the field of biomedical instruments. Consequently, high performance healthcare devices have led to remarkable economic developments in the medical hardware industry. Until now, nearly all optical bio-imaging systems are based on the 2-dimensional imaging chip architecture. In fact, recent developments in digital micromirror devices (DMDs) are gradually
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Photoacoustic detection of circulating melanoma cells in late stage patients J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-08-05 John A. Viator; Marc Hazur; Andrea Sajewski; Ahmad Tarhini; Martin E. Sanders; Robert H. Edgar
Melanoma is the deadliest skin cancer and is responsible for over 7000 deaths in the US annually. The spread of cancer, or metastasis, is responsible for these deaths, as secondary tumors interrupt normal organ function. Circulating tumor cells, or those cells that spread throughout the body from the primary tumor, are thought to be responsible for metastasis. We developed an optical method, photoacoustic
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Multi-manufacturer drug identification based on near infrared spectroscopy and deep transfer learning J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-06-16 Lingqiao Li; Xipeng Pan; Wenli Chen; Manman Wei; Yanchun Feng; Lihui Yin; Changqin Hu; Huihua Yang
Near infrared (NIR) spectrum analysis technology has outstanding advantages such as rapid, nondestructive, pollution-free, and is widely used in food, pharmaceutical, petrochemical, agricultural products production and testing industries. Convolutional neural network (CNN) is one of the most successful methods in big data analysis because of its powerful feature extraction and abstraction ability,
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Tunable absorption characteristics in multilayered structures with graphene for biosensing J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-06-10 Li Jin; Jun Zhou; Puxiang Lai
Graphene derivatives, possessing strong Raman scattering and near-infrared absorption intrinsically, have boosted many exciting biosensing applications. The tunability of the absorption characteristics, however, remains largely unexplored to date. Here, we proposed a multilayer configuration constructed by a graphene monolayer sandwiched between a buffer layer and one-dimensional photonic crystal (1DPC)
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Variable spot size optical system for a dual-wavelength laser therapy device J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-07-04 Ningning Dong; Jinjiang Cui; Jiangen Xu
The majority of existing high-power laser therapeutic instruments employ a single wavelength for a single target; thus, they do not meet the requirements for clinical treatment. Therefore, this study designs an optical system for a dual-wavelength high-power laser therapeutic device with a variable spot size. The waist of the short arm of the optical cavity and the G1G2 parameter (G-parameter equivalent
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A microvascular image analysis method for optical-resolution photoacoustic microscopy J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-07-16 Jingxiu Zhao; Qian Zhao; Riqiang Lin; Jing Meng
Optical-resolution photoacoustic microscopy (OR-PAM) has been shown to be an excellent tool for high-resolution imaging of microvasculature, and quantitative analysis of the microvasculature can provide valuable information for the early diagnosis and treatment of various vascular-related diseases. In order to address the characteristics of weak signals, discontinuity and small diameters in photoacoustic
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Visualizing veins from color skin images using convolutional neural networks J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-07-21 Chaoying Tang; Yimin Yuan; Shuhang Xia; Gehua Ma; Biao Wang
Intravenous cannulation is the most important phase in medical practices. Currently, limited literature is available about visibility of veins and the characteristics of patients associated with difficult intravenous access. In modern medical treatment, a major challenge is locating veins for patients who have difficult venous access. Presently, some products of vein locators are available in the market
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Highly-efficient quantitative fluorescence resonance energy transfer measurements based on deep learning J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-07-30 Lin Ge; Fei Liu; Jianwen Luo
Intensity-based quantitative fluorescence resonance energy transfer (FRET) is a technique to measure the distance of molecules in scale of a few nanometers which is far beyond optical diffraction limit. This widely used technique needs complicated experimental process and manual image analyses to obtain precise results, which take a long time and restrict the application of quantitative FRET especially
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Photocyanine: A novel and effective phthalocyanine-based photosensitizer for cancer treatment J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-05-23 Dan Chen; Meiru Song; Jinling Huang; Naishen Chen; Jinping Xue; Mingdong Huang
As one of the three key components of photodynamic therapy (PDT), photosensitizers (PSs) greatly influence the photodynamic efficiency in the treatment of tumors. Photosensitizers with tetrapyrrole structure, such as porphyrins, chlorins and phthalocyanines, have been extensively investigated for PDT and some of them have already received clinical approval. However, only a few of porphyrin-based photosensitizers
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Ultrabright bimetallic AuAg complex: From luminescence mechanism to biological application J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-06-27 Junchi Chen; Lingfang Liu; Haile Liu; Yonghui Li; Junying Wang; Xiaoyu Mu; Fujuan Xu; Tianyu Liu; Xiao-Dong Zhang
Metal clusters have attracted wide interests due to their unique electronic and optical properties, but the low luminescence quantum yield (QY) prevents them from potential biomedical applications. In this work, silver-doped Au nanoclusters (NCs) are shown to be able to improve the QY of metal clusters. We succeeded in synthesizing ultrabright glutathione (GSH) protected AuAg clusters with 10.8% QY
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Spectra selection methods: A novel optimization way for treating dynamic spectra and in-line near infrared modeling J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-05-20 Haiyan Wang; Ronghua Liu; Lei Nie; Dongbo Xu; Wenping Yin; Lian Li; Hengchang Zang
Near infrared (NIR) spectroscopy is now widely used in fluidized bed granulation. However, there are still some demerits that should be overcome in practice. Valid spectra selection during modeling process is now a hard nut to crack. In this study, a novel NIR sensor and a cosine distance method were introduced to solve this problem in order to make the fluidized process into “visualization”. A NIR
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Black phosphorus as a versatile nanoplatform: From unique properties to biomedical applications J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-05-11 Sha Xiong; Xiaojia Chen; Yao Liu; Taojian Fan; Qi Wang; Han Zhang; Tongkai Chen
Black phosphorus (BP) or phosphorene, a new superstar among two-dimensional (2D) materials, has sparked huge scientific interest since its discovery in 2014. BP offers unique characteristics including high drug loading efficiency, excellent photodynamic and photothermal properties and good biocompatibility. These characteristics expand versatility of BP in nanomedicine. Although the outlook of BP seems
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Optical design and simulation of an integrated OCT and video rigid laryngoscope J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-05-11 Jiajing Kang; Xinyu Li; Mingming Wan; Jiahui Wang; Shanshan Liang; Jun Zhang
An integrated optical coherence tomography (OCT) and video rigid laryngoscope have been designed to acquire surface and subsurface tissue images of larynx simultaneously. The dual-modality system that is based on a common-path design with components as few as possible effectively maintains the light transmittance without compromising the imaging quality. In this paper, the field of view (FOV) of the
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Automated classification of dual channel dental imaging of auto-fluorescence and white lightby convolutional neural networks J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-05-07 Cheng Wang; Haotian Qin; Guangyun Lai; Gang Zheng; Huazhong Xiang; Jun Wang; Dawei Zhang
Prevention is the most effective way to reduce dental caries. In order to provide a simple way to achieve oral healthcare direction in daily life, dual Channel, portable dental Imaging system that combine white light with autofluorescence techniques was established, and then, a group of volunteers were recruited, 7200 tooth pictures of different dental caries stage and dental plaque were taken and
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A novel fluorogenic probe for visualizing the hydrogen peroxide in Parkinson’s disease models J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-04-30 Gaobin Zhang; Zheng Li; Fangjie Chen; Duoteng Zhang; Wenhui Ji; Zhengpeng Yang; Qiong Wu; Chengwu Zhang; Lin Li; Wei Huang
Parkinson’s disease (PD) is closely related to the oxidative stress induced by excess hydrogen peroxide (H2O2) in organisms. Developing an efficient method for noninvasive and real-time H2O2 detection is beneficial to investigate the role played by H2O2 in PD. In this work, a novel fluorogenic probe (CBH) for living organisms H2O2 detection has been designed, synthesized and characterized. The emission
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A comparative study on water and dry coupling in photoacoustic tomography of the finger joints J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-04-17 Qiquan Shang; Man Wu; Jinge Yang; Ten Pan; Guang Zhang; Dan Wu; Huabei Jiang
We present a systematical study on comparison between water and dry coupling in photoacoustic tomography of the human finger joints. Compared to the direct water immersion of the finger for water coupling, the dry coupling is realized through a transparent PDMS film-based water bag, which ensures water-free contact with the skin. The results obtained suggest that the dry coupling provides image quality
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Optically-excited simultaneous photoacoustic and ultrasound imaging based on a flexible gold-PDMS film J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-04-17 Dandan Cui; Zhenhui Zhang; Yujiao Shi
We constructed a flexible gold-polydimethylsiloxane (gold-PDMS) nanocomposites film with controllable thickness and light transmittance, to realize optically-excited simultaneous photoacoustic (PA) and ultrasound (US) imaging under a single laser pulse irradiation. Benefiting from the excellent thermoelastic properties, the gold-PDMS film absorbs part of the incident laser energy and produces a high-intensity
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Combating acoustic heterogeneity in photoacoustic computed tomography: A review J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-03-04 Tong Wang; Wen Liu; Chao Tian
Based on the energy conversion of light into sound, photoacoustic computed tomography (PACT) is an emerging biomedical imaging modality and has unique applications in a range of biomedical fields. In PACT, image formation relies on a process called acoustic inversion from received photoacoustic signals. While most PACT systems perform this inversion with a basic assumption that biological tissues are
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Interaction between Bax and Bcl-XL proteins confirmed by partial acceptor photobleaching-based FRET imaging J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-02-26 Fangfang Yang; Mengyan Du; Xiaoping Wang; Tongsheng Chen
Exact interaction mechanism between Bax and Bcl-XL, two key Bcl-2 family proteins, is an interesting and controversial issue. Partial acceptor photobleaching-based quantitative fluorescence resonance energy transfer (FRET) measurement, PbFRET, is a widely used FRET quantification method in living cells. In this report, we implemented pixel-to-pixel PbFRET imaging on a wide-field microscope to map the
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Time-gated fluorescence imaging: Advances in technology and biological applications J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-02-14 Wenzhao Yang; Sung-Liang Chen
Time-gated (TG) fluorescence imaging (TGFI) has attracted increasing attention within the biological imaging community, especially during the past decade. With rapid development of light sources, image devices, and a variety of approaches for TG implementation, TGFI has demonstrated numerous biological applications ranging from molecules to tissues. The paper presents inclusive TG implementation mainly
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Development of calibration models for rapid determination of moisture content in rubber sheets using portable near-infrared spectrometers J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-02-06 Amorndej Puttipipatkajorn; Amornrit Puttipipatkajorn
Rubber sheets are one of the primary products of natural rubber and are the main raw material in various rubber industries. The quality of a rubber sheet can be visually examined by holding it against clear light to inspect for any specks and impurities inside, but its moisture content is difficult to evaluate based on a visual inspection and this might lead to unfair trading. Herein, we developed
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Intraoperative imaging of oral-maxillofacial lesions using optical coherence tomography J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-02-05 Zihan Yang; Jianwei Shang; Chenlu Liu; Jun Zhang; Fang Hou; Yanmei Liang
Histopathological examination is still the gold standard for diagnoses of oral-maxillofacial lesions, but it is invasive and time-consuming. Optical coherence tomography (OCT) provides a kind of noninvasive, label-free, real-time and high-resolution imaging technology. In this study, in order to assess the feasibility of OCT in oral clinical application, fresh excised tissue specimens from 59 patients
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Photoacoustic reporter genes for noninvasive molecular imaging and theranostics J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-01-31 Zhao Lei; Yun Zeng; Xiaofen Zhang; Xiaoyong Wang; Gang Liu
Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and spatial resolution in deep tissue. Among the various probes developed for PAI, genetically encoded reporters attracted increasing attention of researchers
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Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-01-21 A. Abdurashitov; V. Tuchin; O. Semyachkina-Glushkovskaya
Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the treatment of brain tumors. The newly discovered PDT-induced opening of the blood–brain barrier (BBB) permeability open novel strategies for drug-brain delivery during post-surgical treatment of glioblastoma GBM. Here we discuss mechanisms of PDT-mediated opening of the BBB and age differences in PDT-related
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Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-01-15 Joanne Li; Madison N. Wilson; Andrew J. Bower; Marina Marjanovic; Eric J. Chaney; Ronit Barkalifa; Stephen A. Boppart
To date, numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases, but few have attempted to characterize these cellular events under conditions similar to the native environment. To address this challenge, a three-dimensional (3D) multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin, which was then utilized to process
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Spatial-spectral identification of abnormal leukocytes based on microscopic hyperspectral imaging technology J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2020-01-15 Xueqi Hu; Jiahua Ou; Mei Zhou; Menghan Hu; Li Sun; Song Qiu; Qingli Li; Junhao Chu
Screening and diagnosing of abnormal Leukocytes are crucial for the diagnosis of immune diseases and Acute Lymphoblastic Leukemia (ALL). As the deterioration of abnormal leukocytes is mainly due to the changes in the chromatin distribution, which significantly affects the absorption and reflection of light, the spectral feature is proved to be important for leukocytes classification and identification
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Improving sampling depth of laser speckle imaging by topical optical clearing: A theoretical and in vivo study J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2019-12-26 D. Li; Y. Zhang; B. Chen
The effect of optical cleaning method combined with laser speckle imaging (LSI) was discussed to improve the detection depth of LSI due to high scattering characteristics of skin, which limit its clinical application. A double-layer skin tissue model embedded with a single blood vessel was established, and the Monte Carlo method was used to simulate photon propagation under the action of light-permeating
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Rapid and simultaneous determination of moisture and berberine content in Coptidis Rhizoma and Phellodendri Chinensis Cortex by near-infrared spectroscopy and chemometrics J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2019-12-20 Siyu Zhang; Ming Chen; Yong Chen; Wei Xiao; Yerui Li; Jun Wang; Xuesong Liu; Yongjiang Wu
Coptidis Rhizoma (Chinese: Huanglian) and Phellodendri Chinensis Cortex (Chinese: Huangbo) are widely used Traditional Chinese Medicine, and often used in combination because of their similar pharmacological effects in clinical practice. However, the quality control methods of the two drugs are different and complicated, which is time consuming and laborious in practical application. In this paper
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Classification of hyperspectral images for detection of hepatic carcinoma cells based on spectral–spatial features of nucleus J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2019-12-17 Yao Chen; Siqi Zhu; Shenhe Fu; Zhen Li; Furong Huang; Hao Yin; Zhenqiang Chen
A distinguishing characteristic of normal and cancer cells is the difference in their nuclear chromatin content and distribution. This difference can be revealed by the transmission spectra of nuclei stained with a pH-sensitive stain. Here, we used hematoxylin–eosin (HE) to stain hepatic carcinoma tissues and obtained spectral–spatial data from their nuclei using hyperspectral microscopy. The transmission
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Investigation of optical reflectance from different animal vertebra along the fixation trajectory of pedicle screw in frequency domain J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2019-12-11 Yangyang Liu; Huan Zhang; Ying Tong; Zhiyu Qian; Weitao Li
Accurate placement of pedicle screw (PS) is crucial in spinal surgery. Developing new real-time intra-operative monitoring and navigation methods is an important direction of clinical application research. In this paper, we studied the spectrum along the fixation trajectory of PS in frequency domain to tackle the accuracy problem. Fresh porcine vertebrae, bovine vertebrae and ovine vertebrae were measured
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Review of methods to improve the performance of linear array-based photoacoustic tomography J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2019-12-06 Yuehang Wang; Ye Zhan; Melinda Tiao; Jun Xia
As a hybrid imaging modality that combines optical excitation with acoustic detection, photoacoustic tomography (PAT) has become one of the fastest growing biomedical imaging modalities. Among various types of transducer arrays used in a PAT system configuration, the linear array is the most commonly utilized due to its convenience and low-cost. Although linear array-based PAT has been quickly developed
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Three-dimensional imaging of spatio-temporal dynamics of small blood capillary network in the cortex based on optical coherence tomography: A review J. Innov. Opt. Health Sci. (IF 1.661) Pub Date : 2019-12-03 Fangjian Xing; Jang-Hoon Lee; Collin Polucha; Jonghwan Lee
Optical coherence tomography angiography (OCTA) has emerged as an advanced in vivo imaging modality, which is widely used for the clinic ophthalmology and neuroscience research in the rodent brain cortex among others. Based on the high numerical aperture (NA) probing lens and the motion-corrected algorithms, a high-resolution imaging technique called OCT micro-angiography is applied to resolve the