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Evaluation of subacute toxicity of a polyherbal nootropic formulation in Wistar albino rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-31 Jervin Mano M, Kingshuk Lahon, Mangala Gonepannavar, Kartik J Salwe
In ayurvedic system of traditional medicine, 'medhyarasayanas' — decoction of selected plants are used to improve intellect or cognition abilities. Here, we investigated one such polyherbal formulation (PHF) with ingredients Bacopa monniera, Glycyrrhiza glabra, Valeriana wallechii and Withania somnifera used as a facilitator of learning, retention and recall. We evaluated the safety of this PHF in
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Morinda citrifolia L. (Noni) dietary supplementation ameliorates fluoride toxicity in the freshwater fish, Cyprinus carpio L. Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-31 Ram Krishna Das, Nilay Ray
Fluoride is the organic and inorganic compound of the element fluorine, has detrimental effect to all animals including fish at higher concentration. Ground water with elevated concentration of fluoride is a major global problem including India. On the other hand, Morinda citrifolia (also called ‘Noni’ in Polynesia) is a medicinal plant, has antioxidative, anti-inflammatory and immunostimulatory properties
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Bioprospecting of pods of Moringa oleifera Lam. as novel antibacterial agent Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-31 Devaleena Mukherjee, Goutam Chandra
In the treatment of bacterial diseases, increasing resistance to traditional chemotherapeutics has drawn the necessity for substitute remedies. In this context, here, we evaluated the bactericidal activity of pods of Moringa oleifera Lam., an ethno medicinal plant, against eight pathogenic bacterial strains, both Gram positive (Bacillus licheniformis, B. mycoides, B. subtilis and Staphylococcus aureus)
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Ameliorative effect of sixteen weeks endurance training on biochemical and oxidative damage in high fat diet induced obese rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-31 Seyed Reza Emami, Mahvash Jafari, Rouhollah Haghshenas, Aliasghar Ravasi
Obesity is mainly caused by consumption of high fat diet (HFD) and a lack of physical activity. Physical activity is an efficient strategy to delay development of obesity. In this studyv we tried to evaluate attenuating properties of 16 weeks endurance training on plasma oxidative stress and some biochemical parameters in HFD induced obese rats. Twenty-four male Wistar rats were randomly divided into
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Value of miR-15b-5p combined with ultrasound imaging in early diagnosis of renal cell carcinoma Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-31 Haixia Zhang, Lingfeng Zeng
Renal cancer is one of the most common malignancies, and its incidence is increasing year by year, second only to prostate and bladder cancers. Therefore, early screening is of great significance to prevent and improve the prognosis of patients with renal cancer. Therefore, this study intends to observe the early diagnostic value of miR-15b-5p combined with Colour ultrasound imaging in renal cell carcinoma
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Antimicrobial performance of methanol extract of Foeniculum vulgare Mill. as a sanitizer agent Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-31 Elif Ayşe Erdoğan Eliuz
In food industry, microbial contamination poses a big challenge. Chemicals used for disinfection compromise food safety and therby health. ofThere is an urgent need for effective safe sanitizers for the inhibition of pathogens in agricultural and food products. In this context, here, we investigated the possibility of using the Foeniculum vulgare methanol extract (ME) in the fight against Escherichia
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Effect of some fatty acids on apoptosis related genes in human breast cancer Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-31 Fatma Ezgi Öztecik, Makbule Baylan, Mehmet Bertan Yılmaz
Breast cancer, the second most common cancer after lung cancer, is the most common cancer type diagnosed in women. No definitive treatment has been established for breast cancer yet, but essential fatty acids offer a promising option. Omega fatty acids are classified in the essential fatty acids that the body cannot produce and, therefore, must be taken through the foods of animal or plant origin.
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Anti-inflammatory and antioxidant potential of Artemisia dracunculus L. aqueous extract against acetic acid induced ulcerative colitis in male Wistar rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-02 Priya Kalhor, Mehdi Mohammadzadeh, Seyyed Meysam Abtahi Froushani
Ulcerative colitis (UC) is one of the two types of inflammatory bowel disease (IBD) which is increasing worldover due to modern life style. Patients with UC are prone to develop colorectal cancer. While the disease severity decides the treatment option, researchers look towards herbal medicines with anti-inflammatory properties for minimal or nil side effects. Artemisia dracunculus L., commonly called
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Parasitoid complex of legume pod borer, Maruca vitrata Fabricius (Lepidoptera: Crambidae) on different pulses Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-02 S Sambathkumar, C Durairaj, S Mohankumar, B Preetha, R Aravintharaj, N Ganapathy
The spotted or bean pod borer, Maruca vitrata Fabricius is an important pest of major pulses and vegetable legumes in India and are mostly managed by chemical pesticides. Exploring other alternative management tools, here, we carried out on the availability of parasitoids and its genetic variation to control this major pest. Totally, four larval parasitoids viz., Bassus sp., Trathala flavoorbitalis
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Subacute exposure to dimethoate induces hepatotoxic and nephrotoxic effects on male rats: Ameliorative effects of ferulic acid Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-02 Fatma Gökçe Apaydın, Suna Kalender, Yusuf Kalender
Dimethoate commonly used as environmental ares for control pests which is widely used throughout in the world and itcaused toxic effects on nontarget organisms especially mammalian. Ferulic acid is known to protective compound generally used in toxicology studies. Thus, inthis study, we investigatedthe protective role of ferulic acid against the possible toxic effects of low and high doses of dimethoate
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Antifertility activity of Oroxylum indicum (L.) Kurz: In vitro and in vivo study on human sperm and male wistar rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-02 Banani Das, Kalyan Roy, Anupam Das Talukdar, Amitabha Dey, Khumukcham Nongalleima, Supriya Das, Prasanti Sharma, Manabendra Dutta Choudhury, Lokesh Deb
Oroxylum indicum (L.) Kurz, commonly called as Broken bones tree or Indian trumpet flower, belonging to Fam. Bignoniaceae, is traditionally used as a contraceptive by ethnic people of Tripura, North-East India. Here, we investigated the scientific basis for use of O. indicum as male antifertility agent by folklore healers. In vitro spermicidal activity of aqueous (AEOI) and methanolic (MEOI) extracts
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Effect of acute or subchronic stress on T cell response in peripheral blood: Regulatory role of vitamin D Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-02 Murat Dogan, Ayse Meltem Sevgili, Ilknur Kozanoglu, Bilge Pehlivanoglu
The immune response, orchestrated by helper (Th1, Th2, and Th17) and regulatory (Treg) T cells, is modulated by stress and Vitamin D (Vit-D). Although the immunomodulatory functions of both are known, their specific roles on Th cells have not been fully clarified, yet. On this background, we aimed to investigate the effect of acute or subchronic stress on the distribution of peripheral T lymphocytes
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Modulatory effects of Saccharomyces cerevisiae var. boulardii on experimentally induced benign prostatic hyperplasia in rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-02 Remigius I Onoja, Parker E Joshua, Wilson Obidah, Alloysius C Onyekaba, Anthony C Mgbeahurike, Benjamin I Emesiani
Benign prostatic hyperplasia (BPH) is an age-related non-neoplastic disease of the prostate gland in men that has become a global health issue in recent years. Due to the side effects of conventional treatment options, attention is now focused on phytotherapeutics for its management. We investigated the possible protective effect of Saccharomyces cerevisiae var. boulardii in a rat model of testosterone
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Simultaneous measurement of HbA1C and Hemoglobin by Turbidimetric inhibition immunoassay from a single punch of dried blood spot samples Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-02 Rohini Bingewar, Rajashri Wagholikar, Varsha Kale, Ashwini Shete
Hemoglobin and glycosylated hemoglobin (HbA1C) are frequently monitored health indicators in population based studies for information about the status of nutrition and diabetes control. We present here possibly for the first time the findings of simultaneous estimation of Hemoglobin and HbA1C on Dried blood spot (DBS) samples by a single test. Validation was done by turbidimetric inhibition immunoassay
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Keratinase mediated fabrication and partial characterization of gold nanoparticles and its antibacterial potential Indian J. Exp. Biol. (IF 0.6) Pub Date : 2023-01-02 Balraj Sudha, KS Athinath, Vivek Swabna, Sundaravadivelu Sumathi
Keratinase is mainly involved in recycling of keratin waste. Of late, researchers extended its application to nanotechnology. In the present study, we have made an attempt to fabricate and characterize gold nanoparticles using crude keratinase enzyme from Serratia ficaria and also study their biological application, particularly antibacterial activity. The formation of gold nanoparticles (AuNPs) was
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Benchmarking of different microbes for their biosurfactants antifungal action against plant pathogens Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-12-02 Khem Raj Meena, Satyam, Ashutosh Singh, Aman Jaiswal, Dinesh Rai
The biotic stress caused by phytopathogens (bacteria, fungus, yeast and insect pests) is a primary factor in yield loss of plants. Biocontrol agents and their active compounds are used to manage such plant pathogens. Here, in our study, we screened four bacterial isolates identified as Bacillus cereus, B. anthracis, B. velezensis and Serratia marcescens after morphological, biochemical and molecular
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Histochemical characterization of duodenum at early, mid and late prenatal period in goats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-12-02 Abhinov Verma, Muneer Mohammad Farooqui, Muneer Mohammad, Archana Pathak, Shriprakash Singh, Varsha Gupta
Goats [Capra aegagrus hircus (L.)] play a significant role in providing supplementary income and livelihood to humans. The intestine plays a major role in foetus development and growth, and duodenum, as the part of small intestine, is responsible for breakdown of food. As there is not much studies available in literature on this aspect, here, we investigated the developing duodenum of 30 goat embryos/foeti
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Hepatoprotective potential of isolated flavonoids from Trapa natans L. against the paracetamol induced oxidative stress in rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-12-02 Chandana Majee, Rupa Mazumde, Alka N Choudhary
Overdose of paracetamol causes liver toxicity, due to oxidative stress by the reactive oxygen species (ROS) that increases the levels of ALT and AST, and reduces the level of the antioxidant enzymes. Flavonoids are a source of natural antioxidants that assist in neutralization of ROS. Several studies have suggested that flavonoids can help protect the liver. The Water Chestnut, Trapa natans L. plants
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Extraction and partial characterization of exopolysaccharides and pigments from cyanobacterium Oscillatoria pseudogeminata G.Schmid Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-12-02 Ramasamy Thangaraj, Nooruddin Thajuddin
Cyanobacterial pigments such as chlorophyll, carotenoids and phycobiliproteins are considered as ecofriendly natural colourants used in food and food additives as they have nutraceutical value, non-toxic and non-carcinogenic. The present study focused on extraction, partial characterization of extracellular polysaccharides (EPS), phycocyanin and mycosporin like amino acid (MAA) from a freshwater cyanobacterium
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Phenotypic diversity and stability of early maturing Barnyard Millet (Echinochloa sp.) germplasm for grain yield and its contributing traits Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-12-02 Kuraloviya M, Vanniarajan C, Sudhagar R, Vetriventhan M
maturing cultivars is one of the important breeding goals in barnyard millet, which can fit well when main crops fail, or during the late onset of monsoon. Thus, this study was carried out to test the phenotypic diversity, character association and path coefficients, and stability of early maturing barnyard millet accessions. The MDU 1, a slightly late-maturing (95 days) cultivar, was used to identify
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Hepatoprotective effect of obeticholic acid on acetaminophen induced hepatotoxicity in mice Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-12-02 Amit Awasthi, Prathyusha Lakshmi Vinjarapu, Venkataraman Krishnamurthy, Sthevaan Vincent, Anil Potturi, Suresh Juluri, Lakshman Rajagopalan
Acetaminophen (APAP) is commonly used as analgesic and antipyretic drug for relieving mild and moderate pain, but at high doses produces hepatic necrosis. Though, Obeticholic acid (OCA) has been tested in range of diseases, its therapeutic potential against APAP-induced hepatic injury remains to be elucidated. Thus, in this study, we investigated the preventive effect of OCA along with N-acetylcysteine
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Effect of SKB-Gutbiotic on acetic acid induced ulcerative colitis in male Wistar rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-12-02 Mahalaxmi Mohan, Parag Saudagar, Mitali Dalvi
Inflammatory bowel disease (IBD) is a chronic intestinal inflammation gaining increasing attention as it affects considerable number of humans. IBD is reported as ulcerative colitis (UC) and Crohn's disease (CD) Conventional therapies currently available are not satisfactory. Therefore, here, we investigated the effect of SKB-Gutbiotic on acetic acid induced ulcerative coltis (UC) in male Wistar rats
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Antitumor impact of amygdalin on adaptive immune response in BALB/c mice with breast cancer Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-12-02 Aboolfazl Yavari, Fateme Zare, Fateme Dashti, Hamideh Valizadeh, Farzaneh Fesahat, Mahdi Dehghan Manshadi
Amygdalin is a potential therapeutically target in cancer. Here, we evaluated the therapeutic effect of amygdalin in the mice model of breast cancer. We assessed the percentage of CD4, CD8 T lymphocyte, intracellular IFN-γ, and Granzyme B in spleen cells of tumorized mice treated with 50 and 150 mg/kg of amygdalin (AG50 and AG150), and determined the expression of caspase 3 and p53, tumor size, and
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Effect of electrical stimulation on oxidative stress in tissues in a rat model with incision wound Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-26 Filiz Kazak, Egemen Işık, Ziya Yurtal, İbrahim Alakuş
Electrical stimulation (ES) are known to have beneficial effects in wound healing. However, the effect of electrical stimulation in wound theraphy on the oxidant and antioxidant levels of various tissues in the body remains unclear. Here, we investigated the effects of electrical stimulation on the oxidative stress capacity of tissues in a rat model with a surgical incision wound on the lateral line
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Ginsenoside Rb1 promotes angiogenesis potentially by activating the JAK-STAT3 signalling pathway Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-26 Zhiqiang Gong, Sha Han, Xianfu Liu, Wenjun Tang, Tianxiu Meng, Yanhong Huang, Lifang Yang, Chenglin Li
Conventional revascularization strategies for ischemic heart disease (IHD) are designed to prompt reperfusion of the coronary artery to the salvaged cardiomyocytes. However, these strategies may cause myocardial reperfusion injuries. Therefore, a safe and effective strategy needs to be developed to improve the conventional strategies. Here, we investigated the pro-angiogenic effect of Ginsenoside Rb1
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Evaluation of the heavy metals tolerant UV rays treated bacteria isolated from anthropogenic sites of Chambal region, India Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-26 Akanksha Gupta, Swati Chitranshi, Alok Dwivedi, Sonia Johri
Industrial waste is released into the environment and leads to various types of heavy metal, which are toxic, mutagenic and carcinogenic in nature. Heavy metals are not biodegradable but accumulated by living organisms and cause diseases at even low concentrations. In this study, we selected four anthropogenic sites from Chambal region, isolated bacteria and investigated its heavy metal removal capability
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HPLC analysis, acute toxicity and anti-inflammatory effects of Salix alba L. barks extracts on experimental animal models Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-26 Imene Roumili, Nozha Mayouf, Noureddine Charef, Lekhmici Arrar, Abderrahmane Baghiani
The white willow, Salix alba L., rich in polyphenols and flavonoids, is traditionally used for its antipyretic, analgesic and anti-inflammatory potential in Algeria. As part of the ethnobotanical survey of medicinal plants in Setif region in Algeria, in the present study, we assessed the safety profile of S. alba barks methanol (SAME) and aqueous (SAQE) extracts, their phytoconstituents, and their
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Isolation and therapeutic efficacy of enteropathogenic E. coli phage cocktail against colibacillosis in neonatal goats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-26 Anil Kumar Mishra, Ashok Kumar, K Gururaj, Akriti Dixit, Abhishek, Vinay Chaturvedi, Chetna Gangwar, Nitika Sharma
Phage based therapeutics have shown promising results against the infections caused by the drug resistant bacteria. To combat the problem of antibiotic resistance posed by diarrhoeagenic E. coli, here, we identified and characterized 38 E. coli phages which were isolated from 70 solid sources (goat-faeces and soil). The in vitro lytic range of phage isolates (n=38) against 439 isolates of E. coli was
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Biopotency and toxicity of diverse group of insecticides under laboratory condition against sunflower defoliator Spilarctia obliqua (Walker) Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-26 Pandit, Veeranna R, Honnakerap S. Ballari
The biopotency and toxicity of two groups, conventional and newer insecticides [eight commercial insecticides] were determined against Bihar or Common hairy caterpillar (BHC) Spilarctia obliqua (Walker). Experiment carried out in the laboratory by exposing BHC larvae to insecticides. Biopotency was measured at different time intervals from 12-72 h after insecticidal application showed that all of the
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Improved bioassay method for evaluation of oviposition deterrents against Old World bollworm, Helicoverpa armigera (Hübner) Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-26 Rachna Pande, Shah Vivek, Pooja Verma, Nandini Gokte-Narkhedkar, Vijay N. Waghmare
Old world bollworm Helicoverpaarmigera (Hübner) is one of the serious pests of agricultural crops with more than 184 recorded hosts including cotton. In cotton, H. armigerausually causes yield losses up to 40% with 20-80% damage intensity. In the Indian context it has already developed resistance to most conventional classes of insecticide and its survival on Bt cotton also has been reported in some
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DNA methylation in bryophytes as a biomarker for monitoring environmental pollution Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-26 Meliha Merve Hiz Çiçekliyurt, Ozlem Tonguc Yayintas
Rapidly growing industrialization and increased need for transportation have led to environmental pollution, particularly heavy metals. Efficient monitoring would help planning effective strategies to curb such increasing pollution. In this context, we studied the epigenetic changes in the bryophyte Greater Fork-moss, Dicranum majus Turner so as to use to monitor the environmental stress conditions
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Royal jelly significantly alters inflammasome pathways in patients with chronic hepatitis B Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-10-25 Morteza Bahaaldin-beygi, Ashraf Kariminik, Mohammad Kazemi Arababadi
Royal jelly (RJ) plays immunomodulatory role in humans. Further, role played by inflammasomes against hepatitis B virus (HBV) and involvement in its complications are well known. Here, we evaluated the effects of RJ on the relative expression of apoptosis associated with speck-like protein (ASC), node like receptor (NLR) family pyrin domain containing 1 (NLRP1), NLRP3, S100 calcium binding protein
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Cultural, morphological and molecular diversity of Ustilaginoidea virens (Cooke) Tak. isolates causing false smut of rice in different agroclimatic regions of Karnataka Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-29 Savitha AS, Nagaraja A, Ajithkumar K, Prasannakumar MK
The ascomycete fungal pathogen Ustilaginoidea virens (Cooke) Takahshi cause false smut in rice and considerable yield loss. In this study, we collected isolates of U. virens from the rice growing ecosystems of Karnataka and characterized for cultural, morphological and molecular characters. The isolates of the fungus on Potato Sucrose Agar media exhibited distinct colonies with colony growth ranging
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Escherichia coli biofilm formation and control by phenolic compounds from Salvia officinalis L. extracts Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-29 Olgica Stefanović, Dijana Mladenović, Katarina Mladenović, Mirjana Grujović, Dragana Ivanović
Biofilm is recognized as one of the virulence factors of uropathogenic Escherichia coli. It offers bacteria significantly increased tolerance to antibiotics and makes difficulties in infection eradication. In this study, the biofilm formation ability of clinical isolates of uropathogenic E. coli as well as the antibiofilm activity of the common Garden sage, Salvia officinalis L.extracts were investigated
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Enhancement of mangiferin by fungal endophytes isolated from Salacia chinensis L. and Salacia oblonga Wall. Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-29 Jasmeet Kaur, Minakshi Verma, Bibhu Prasad Panda, Vidhu Aeri
Microbes residing in the internal tissues of a plant are called endophytes, and are known for producing phytochemicals such as taxol, podophyllotoxin, azadirachtin and vinca alkaloids. In this study, out of five isolates from Salacia species, two fungi Penicillium capsulatum and Aspergillus fumigatus have been evaluated and confirmed by polymerase chain reaction (PCR) amplification for their endophytic
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Effect of herbicide based formulations on structure and function of testis in rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-29 Vaishali T. Phusate
Herbicides are known to add toxicity to the soil as their side effect. Farmers use either Paraquat based (PBF) or Glyphosate based (GBF) herbicide formulations for instant management of weeds. Here, we investigated the effect of PBF Gramoxone® and GBF Roundup® on the structure and function of the testis of the male Wistar rats at the pubertal or post pubertal stage. Male rats were gavaged with Gramoxone®
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Biosorption of Zinc using Bacillus subtilis (MTCC 2423) Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-29 Rajalakshmi R, Surendran A, Thatheyus AJ
Heavy metals such as zinc in untreated industrial effluents cause diseases and disorders in living organisms. They cannot be degraded like organic contaminants and hence have to be removed. Though physical and chemical methods are available for their removal, most of them are not economical and eco-friendly. Hence, a suitable technique is necessary to minimize the deleterious effects of dispersion
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Significance of fermented rice beverage on management of antibiotic associated diarrhea (AAD) on Wistar rats Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-29 Birendra Kumar Mishra, Sujit Das, Jashbhai B. Prajapati, Maulik Patel, Dineshkumar J. Ghodasara, Mohsinkhan Pathan, Subrota Hati
Antibiotic associated diarrhoea (AAD) is caused mostly by disruption of the physiological gut microflora. One potential strategy to prevent this is the concurrent use of probiotic bacteria or yeast. Tribal populations of West Garo Hill region of Meghalaya use locally available unique microflora to prepare fermented food products whichserve as a potential source of novel probiotic organisms and bioactive
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LC-MS/MS profiles, multielement levels and biological activities of Hypericum heterophyllum Vent. Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-29 Omer Hazman, Laçine Aksoy, Ahmet Büyükben, Recep Kara, Mustafa Kargıoglu, İbrahim Hakkı Cigerci, Mustafa Abdullah Yılmaz
Plants belonging to the genus Hypericum L. are widely used in traditional folk medicine due to their hypericin and pseudohypericin contents. In this study, we investigated the biological activity, phenolic and elemental content of methanol and acetone extracts of sheepskin grass, Hypericum heterophyllum Vent. a species that that lacks both hypericin and pseudohypericin. The total antioxidant status
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Antiproliferative and cytotoxic activities of Mentha x piperita L. essential oil in non-small cell lung cancer cells Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-29 Dilge Yücel, Canan Vejselova Sezer, Ersin Yücel, Hatice Mehtap Kutlu
Among 33 types of listed cancers worldwide, lung cancer with 2.2 million cases (12.2% of total cancer cases) ranks second next only to breast cancer. Globally, Turkey, with overall rate of 40.0 (41,264 cases), ranks 5th among the top 10 countries in lung cancer. Currently used therapeutic agents and approaches have considerable side effects, and hence, there is a need for alternative agents for effective
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Bioconversion of glycerol waste to ethanol by Escherichia coli and optimisation of process parameters Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Chaitanya Reddy Chilakamarry, AM Mimi Sakinah, AW Zularism, Irshad Ahamad Khilji, Ranjna Sirohi, Venugopal Jayarama Reddy
Biofuel is one of the best ways to reduce our dependence on fossil fuels. Ever since commercial biodiesel production began, waste glycerol, the biodiesel byproduct, has gained researchers’ interest, especially its recycling. Here, we explored using glycerol residue (carbon source) as a substrate in the fermentation process for ethanol production by Escherichia coli K12 in anaerobic conditions. The
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HPLC/QTOF-MS metabolomics analysis applied to identify skin biomarkers of UVC-induced skin injury in mice and preventive effects of abietic acid Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Nianyun Yang, Jiaojiao Qian, Lijuan Tian
Abietic acid (AA) is a main constituent from pine resin, which has definite therapeutical effects for treating skin ulcers and tumor. Here, we explored the metabolome changes in skin tissues of mice with UVC-induced skin injury treated with AA by a HPLC-QTOF-MS/MS method. Model mice were induced with UVC irradiation. Skin histopathological changes were examined by routine HE staining. Metabolomic analysis
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Trametes versicolor (L.) Lloyd as a source of thermostable serine protease: production and characterization Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Reena Vishvakarma, Archana Vimal, Abha Mishra, Poonam Sharma, Vivek Kumar Gaur
Proteases are ubiquitously present and are among the largest groups of commercially important enzymes. Here, we investigated a wood-rot basidiomycete Trametes versicolor (L.) Lloyd [Syn. Coriolus versicolor (L.) Quél.; Polyporus versicolor (L.) Fr.] as a source of the enzyme serine protease, its production, and optimized to obtain a higher yield of the enzyme.. The significant variables with optimized
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Evaluation of some effective potentialities of newly formulated rice fermented food using Elephantopus scaber L. rhizome as herbal starter Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Papan K. Hor, Kuntal Ghosh, Suman Kumar Halder, Subhadeep Mondal, Keshab Chandra Mondal
Traditionally, fermented food and beverages are prepared by adding a mixture of plant residues as a starter or source of microbes. Most of the conventional fermented foods use a local starter which contains a mixture of herbs or old ferment or otherwise cereal dust-coated tablet. In this study, we have made an attempt to prepare a rice-based fermented food with the herbal starter (0.5% w/w) of Elephantopus
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Reutilization of waste fungal biomass for concomitant production of proteo-chitinolytic enzymes and their catalytic products by Alcaligenes faecalis SK10 Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Kalyanbrata Pal, Subham Rakshit, Subhadeep Mondal, Arijit Jana, Keshab Chandra Mondal, Suman Kumar Halder
Fungal biomass, being organic waste, could be an excellent source of protein, carbohydrate and minerals. However, it has not been exploited fully until now. Efficient management of this waste can not only address the environmental impact on its disposal but also yield value-added metabolites. In the present study, in order to explore its potential, we subjected dead fungal biomass of Aspergillus niger
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Insight into strigolactone hormone functions in plant parasitic weeds: a regulatory perspective Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Rakesh Srivastava, Rajesh Bajpai, Zeba Khan, Surendra Pratap Singh, Rajesh Mehrotra, Neeraj Kumar Dubey
The strigolactones (SLs) are plants hormones that have multiple functions in architecture and development. The roles of SLs in shoot branching and stem secondary growth of autotrophic plants are established. SL is also involved in the interaction between root parasitic plants and their host plants. SLs are exudates by the root of the host plant in search of a fungal partner for symbiotic association
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Dietotherapeutic potency of ornamental lentil dumpling, a traditional food preparation from South West Bengal, India Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Saswati Parua Mondal, Kuntal Ghosh, Papan K. Hor, Saptadip Samanta, Keshab Chandra Mondal
Gahana bori (in Bengali) or ornamental lentil dumpling is a state-of-art preparation designed in the form of paisleys, ornaments or flowers, used as a decorative adjunct with the main dish.. Here, we have made an attempt to evaluate the dirtotherapeutic potency of this traditional preparation. The principal ingredient is the Vigna mungo (blackgram/ urad bean). In its preparation, the soaked bean is
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Assessment of genotoxicity induced by helminthes parasites in freshwater fishes of river Ganges Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Neeshma Jaiswal, Rashmi Srivastava, Rakesh Srivastava, Suman Mishra, Kamal Jaiswal, Sandeep Malhotra
Several parasites have been shown to induce genotoxicity in humans and fish are important intermediate hosts for completing the life cycle of many parasites, posing a huge economic loss worldwide through the ecosystem food chain. In the present study, we assessed the genotoxic potential of helminth Rostellascaris sp. through a benchmark of comet assay and micronucleus (MNi) tests on the hepatocytes
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Safety and preventive effects of rivaroxaban and low-molecular-weight heparin on deep vein thrombosis of lower extremity after total hip arthroplasty Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Youchen Ye, Zhifang Zhao
Deep vein thrombosis (DVT) is a common complication of skeletal surgery, which can cause disability and death in severe cases. Here, we have compared the preventive effects of rivaroxaban and low molecular weight heparin on DVT of lower extremity after total hip arthroplasty and the safety. A total of 310 patients who received total hip arthroplasty from May 2014 to June 2016 were divided into a rivaroxaban
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F-box motif encoding genes as targets for the development of stress-tolerant traits in Saccharomyces cerevisiae Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Meenu Sharma, Monika Pandita, Heena Shoket, Narendra K Bairwa
Stress tolerance is a useful trait actively sought by the bioprocess industry for biofactories dealing with bioconversion of varied raw materials or carbon sources. Fungal or yeast species are useful in bioconversion and are sustainable bioresources for biochemicals and biofuel production. Genetic manipulation strategies are in practice to enhance the tolerance against stress agents for the improved
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Aspergillus spp., a versatile cell factory for enzymes and metabolites: Interventions through genome editing Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-09-01 Aravind Madhavan, Arun KB, Raveendran Sindhu, Parameswaran Binod, Mukesh Kumar Awasthi, Ashok Pandey
Aspergillus sp. is widely distributed in nature and plays significant roles in the degradation of lignocellulose biomass and extensively used in bioprocess and fermentation technology and many species are also a generally regarded safe. Many of the Aspergillus species are established cell factories due to their inherent capacity in secreting large number of hydrolytic enzymes. With the advent of next
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Hepatopancreatic contributions of lipids and carotenoids to vitellogenesis in the intertidal anomuran crab, Emerita asiatica (Milne Edwards) Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-08-01 Persia Jothy T, Rajesh Kannan R, Subramoniam T
In decapod crustaceans, lipids and the associated carotenoid pigments form an integral part of yolk to serve as nutrients during embryogenesis. This study reports on the analysis of different lipid classes and the major carotenoids in the ovary, hepatopancreas and hemolymph and their fluctuation during different phases of ovarian maturation in an anomuran crab, Emerita asiatica. Neutral lipids including
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Local and systemic effects of adrenomedullin after intestinal ischemia reperfusion Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-08-01 Eser Oz Oyar, Zuhal Yildirim, Arzu Pampal, Ayse Sebnem Ilhan, Nese Lortlar Unlu
Adrenomedullin (AM) is a peptide proven to increase cellular tolerance to hypoxia and oxidative stresss and contribute angiogenesis. Despite its known therapeutic effects on myocardial, renal or spinal ischemic reperfusion injuries, its local and systemic effects on intestinal ischemic reperfusion injury still remain unknown. This study aims to demonstrate the local and systemic effects of AM on Intestinal
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Bioactive extract of mycelia biomass of Ganoderma lucidum protects doxorubicin induced cardiomyopathy Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-08-01 Ravindran K Veena, Thekkuttuparambil A Ajith, Kainoor K Janardhanan
Cardiotoxicity induced by anticancer drug; doxorubicin (DOX) is a limiting factor for its prolonged use in chemotherapy. No effective drug is currently available to prevent DOX induced cardiomyopathy. Ganoderma lucidum is highly valued medicinal mushroom used in traditional medicine. Mycelia biomasses are considered as alternate sources of mushroom bioactive compounds. We examined the effect of bioactive
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Therapeutic effect of propolis on Staphylococcus aureus induced oxidative stress in kidney of BALB/c mice. A biochemical and histopathological study Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-08-01 Anita Rana, Neelima R Kumar, Jaspreet Kaur
Due to emerging drug resistance in pathogenic organisms, most of the second generation antibiotics are not effective in controlling the disease. As a consequence, the dosage and duration of drug intake has increased leading to drug induced toxicity and various side effects. A large number of natural products are being reported to ameliorate the toxicity and oxidative stress caused by antibiotics. Here
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Cloning and characterization of phloroglucinol biosynthetic gene phlC from an Indian strain of Pseudomonas fluorescens Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-08-01 Payal Gupta, Kesiraju Karthik, Rohini Sreevathsa, Rhitu Rai, Prasanta K Dash
Phloroglucinol or 2,4-diacetyl phloroglucinol (DAPG) is a polyketide compound produced by gram negative soil bacteria Pseudomonas. It shows broad spectrum antibacterial and antifungal properties against soil-borne plant pathogens. In Pseudomonas spp., genes for biosynthesis of 2,4-DAPG are localized in phlABCD operon. All the four genes in phlABCD operon are indispensable and DAPG synthesis is attenuated
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Physiochemical response of papaya genotypes exposed to low temperature regimes Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-08-01 Maurya NK, Goswami AK, Goswami S, Singh SK, Prakash J, Chinnusamy V, Talukdar A, Behera TK, Pradhan S
Susceptibility to low temperature stress is the major threat to papaya cultivation. Here, we studied a low temperature stress tolerance in papaya plant. We have investigated the effect of different low temperature regimes, 28°/18°C (day/night) to 16°/06°C (day/night) with a gradual decrease of 2°C on every two days and one set with direct exposure to the low temperature of 18°/08°C (day/night), called
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Physiological studies and nutrient accumulation in mustard varieties in response to fertilizer doses under saline condition in semi-arid region of northwestern Haryana Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-08-01 Priyanka, Ram Prakash, Ankush, Sarita Devi, Rajpaul, Rameshwer Singh
The present study was conducted to findout the salt tolrant mustard variety for semi-arid region because this region has higher amount of poor quality water for irrigation and nutrient accumulation under saline environment is the most limiting factor in the sustainable crop production. For this four mustard varieties in main plots (Kranti, Giriraj, CS-54, and CS-58) and three fertilizer doses in sub-plots
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In vitro evaluation of free flavonoids in Cassia fistula Linn. calli of different ages under varying concentrations of plant growth regulators (PGRs) Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-08-01 Sushil Kumar, Yerramilli Vimala, Ishwar Singh
Cassia fistula Linn, a paramount medicinal plant consumed by huge population all over the world. Its bioactive metabolites include flavonoids, phenolics, and polyphenols. Major objective of current study is to find right media combination and age of callus for maximum accumulation of free flavonoids in Cassia fistula cultures. In this study, the calli were induced in MS + 1.0 mg/L 2,4-D + 0.05 mg/L
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Forkhead box A1 expression in thyroid carcinoma based on bioinformatics and clinical significance Indian J. Exp. Biol. (IF 0.6) Pub Date : 2022-07-11 Jinglu Wang
Thyroid cancer, known to be common in women than men, accounts for 12% all types of cancers and ranks 9th with 5,86,202 cases worldwide. Role of forkhead box A1 (FOXA1), also known as hepatocyte nuclear factor 3α and involved in the oncogenesis and progression of several tumors such as gliomas, breast, stomach, lung, ovarian, and esophageal cancers, has not been elucidated well in thyroid carcinoma