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Fathers and sons, mothers and daughters: Sex-specific genetic architecture for fetal testosterone in a wild mammal Horm. Behav. (IF 3.5) Pub Date : 2024-03-06 Ruth Fishman, Simona Kralj-Fišer, Sivan Marglit, Lee Koren, Yoni Vortman
Testosterone plays a critical role in mediating fitness-related traits in many species. Although it is highly responsive to environmental and social conditions, evidence from several species show a heritable component to its individual variation. Despite the known effects that in utero testosterone exposure have on adult fitness, the heritable component of individual testosterone variation in fetuses
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The role of exogenous testosterone and social environment on the expression of sociosexuality and status-seeking behaviors in young Chilean men Horm. Behav. (IF 3.5) Pub Date : 2024-03-06 Pablo Polo, Gabriela Fajardo, Jose Antonio Muñoz-Reyes, Nohelia T. Valenzuela, Montserrat Belinchón, Oriana Figueroa, Ana Fernández-Martínez, Marcel Deglín, Miguel Pita
Testosterone plays an important role as a social hormone. Current evidence suggests that testosterone is positively related to sociosexuality increasing the psychological attitudes toward investing in short-term versus long-term mating and promotes status-seeking behaviors both by dominance and prestige. In addition, the social environment may play an important role in the expression of mating effort
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Social regulation of arginine vasopressin and oxytocin systems in a wild group-living fish Horm. Behav. (IF 3.5) Pub Date : 2024-03-06 Brett M. Culbert, Isaac Y. Ligocki, Matthew G. Salena, Marian Y.L. Wong, Ian M. Hamilton, Nicholas J. Bernier, Sigal Balshine
The neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) are key regulators of social behaviour across vertebrates. However, much of our understanding of how these neuropeptide systems interact with social behaviour is centred around laboratory studies which fail to capture the social and physiological challenges of living in the wild. To evaluate relationships between these neuropeptide systems
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Estrogenic influences on agonistic behavior in teleost fishes Horm. Behav. (IF 3.5) Pub Date : 2024-03-06 Katherine A. Stennette, John R. Godwin
Teleost fishes show an extraordinary diversity of sexual patterns, social structures, and sociosexual behaviors. Sex steroid hormones are key modulators of social behaviors in teleosts as in other vertebrates and act on sex steroid receptor-containing brain nuclei that form the evolutionarily conserved vertebrate social behavior network (SBN). Fishes also display important differences relative to tetrapod
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Low dose of propyl-pyrazole-triol, an agonist of estrogen receptor alpha, administration stimulates the Coolidge effect in fadrozole-treated male rats Horm. Behav. (IF 3.5) Pub Date : 2024-03-05 P. Hanna C. Corre, Joanna M. Mainwaring, K. Kenn Z. Peralta, P. Mark Lokman, Robert Porteous, Erik Wibowo
Estrogen receptor (ER) α is involved in male sexual function. Here, we aim to investigate how ERα activation influences sexual satiety and the Coolidge effect (i.e., when a rat, that has reached sexual satiety, experiences an increased arousal after exposure to a novel sexual partner) in estrogen-deprived male rats. Male rats (8 per group) were treated daily for 29 days with either saline (Control
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G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different signaling mechanisms than in female mice Horm. Behav. (IF 3.5) Pub Date : 2024-03-01 Gustavo D.B. Machado, Alexis L. Schnitzler, Aaron W. Fleischer, Sarah B. Beamish, Karyn M. Frick
Studies in ovariectomized (OVX) female rodents suggest that G protein-coupled estrogen receptor (GPER) is a key regulator of memory, yet little is known about its importance to memory in males or the cellular mechanisms underlying its mnemonic effects in either sex. In OVX mice, bilateral infusion of the GPER agonist G-1 into the dorsal hippocampus (DH) enhances object recognition and spatial memory
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Neural thyroid hormone metabolism integrates seasonal changes in environmental temperature with the neuroendocrine reproductive axis Horm. Behav. (IF 3.5) Pub Date : 2024-02-28 Deborah I. Lutterschmidt, Kalera Stratton, Treven J. Winters, Stephanie Martin, Lauren J. Merlino
We asked if environmental temperature alters thyroid hormone metabolism within the hypothalamus, thereby providing a neuroendocrine mechanism by which temperature could be integrated with photoperiod to regulate seasonal rhythms. We used immunohistochemistry to assess the effects of low-temperature winter dormancy at 4 °C or 12 °C on thyroid-stimulating hormone (TSH) within the infundibulum of the
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The effects of diazepam on fear extinction in nulliparous and primiparous female rats Horm. Behav. (IF 3.5) Pub Date : 2024-02-28 Jodie E. Pestana, Tasfia Kabir, Bronwyn M. Graham
Benzodiazepines undermine the success of exposure therapy in humans with anxiety disorders, and impair the long-term memory of fear extinction (the laboratory basis of exposure therapy) in rodents. However, most rodent studies on fear extinction and benzodiazepines have been conducted in male rodents. In female rodents, the estrous cycle influences the consolidation of fear extinction memories and
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Repeated exposure to physiologically effective doses of contraceptive hormones ethinyl estradiol or levonorgestrel do not alter the reinforcing effects of a brief visual stimulus in ovary-intact rats Horm. Behav. (IF 3.5) Pub Date : 2024-02-22 Kathleen R. McNealy, Matthew W. Oevermann, MacKenzie L. Knabel, Anna Fitzwater, Cassandra D. Gipson, Scott T. Barrett, Rick A. Bevins
Estradiol and progesterone potentiate and attenuate reward processes, respectively. Despite these well-characterized effects, there is minimal research on the effects of synthetic estrogens (e.g., ethinyl estradiol, or EE) and progestins (e.g., levonorgestrel, or LEVO) contained in clinically-utilized hormonal contraceptives. The present study characterized the separate effects of repeated exposure
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How new communication behaviors evolve: Androgens as modifiers of neuromotor structure and function in foot-flagging frogs Horm. Behav. (IF 3.5) Pub Date : 2024-02-21 Lisa A. Mangiamele, AllexAndrya Dawn, Kerry M. LeCure, Gina E. Mantica, Riccardo Racicot, Matthew J. Fuxjager, Doris Preininger
How diverse animal communication signals have arisen is a question that has fascinated many. frogs have been a model system used for three decades to reveal insights into the neuroendocrine mechanisms and evolution of vocal diversity. Due to the ease of studying central nervous system control of the laryngeal muscles in vitro, has helped us understand how variation in vocal communication signals between
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The decanoate esters of nandrolone, testosterone, and trenbolone induce steroid specific memory impairment and somatic effects in the male rat Horm. Behav. (IF 3.5) Pub Date : 2024-02-17 Sofia Zelleroth, Frida Stam, Erik Nylander, Ellinor Kjellgren, Johan Gising, Mats Larhed, Alfhild Grönbladh, Mathias Hallberg
Long-term use of anabolic androgenic steroids (AAS) in supratherapeutic doses is associated with severe adverse effects, including physical, mental, and behavioral alterations. When used for recreational purposes several AAS are often combined, and in scientific studies of the physiological impact of AAS either a single compound or a cocktail of several steroids is often used. Because of this, steroid-specific
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Thyroid hormone concentrations in female baboons: Metabolic consequences of living in a highly seasonal environment Horm. Behav. (IF 3.5) Pub Date : 2024-02-15 Laurence R. Gesquiere, Christine Adjangba, Tim L. Wango, Vivian K. Oudu, Raphael S. Mututua, J. Kinyua Warutere, I. Long’ida Siodi, Fernando A. Campos, Elizabeth A. Archie, A. Catherine Markham, Susan C. Alberts
How female mammals adapt metabolically in response to environmental variation remains understudied in the wild, because direct measures of metabolic activity are difficult to obtain in wild populations. However, recent advances in the non-invasive measurement of fecal thyroid hormones, triiodothyronine (T3), an important regulator of metabolism, provide an opportunity to understand how female baboons
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Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling Horm. Behav. (IF 3.5) Pub Date : 2024-02-14 Rashmi Patil, Urmila Aswar, Nishant Vyas
Cafeteria diet (CD) model for in-vivo studies mimics the western diet having imbalanced nutritional value, high caloric-density and palatability. Uncontrolled eating leads to the development of childhood obesity, poor self-esteem and depression due to its effects on brain development. Herbal supplements are novel inclusion in the management of obesity and mental well-being. Pterostilbene (PTE) found
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Delivery by cesarean section leads to heavier adult bodyweight in prairie voles (Microtus ochrogaster) Horm. Behav. (IF 3.5) Pub Date : 2024-02-13 William M. Kenkel, Sabreen Ahmed, Miranda Partie, Katelyn Rogers
Delivery by cesarean section now makes up 32.1 % of all births in the United States. Meta-analyses have estimated that delivery by cesarean section is associated with a > 50 % increased risk for childhood obesity by 5 years of age. While this association is independent of maternal obesity, breastfeeding, and heritable factors, studies in humans have been unable to test for a causal role of cesarean
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Effects of intrauterine position during gestation on specific endocrine and behavioral parameters that impact reproduction in domestic rabbits Horm. Behav. (IF 3.5) Pub Date : 2024-02-10 Lizet García-Fernández, David R. Chavira, Kurt Hoffman, Gabriela González-Mariscal
Prior studies from others, performed in a different breed, reported that doe rabbits developing between two male siblings (2 M) during gestation display characteristics indicative of masculinization: larger anogenital distance (AGD), larger submandibular glands, and higher chinning frequency than females with zero (0 M) or one (1 M) contiguous brothers. Similar effects are provoked by injecting androgens
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Odours of caterpillar-infested trees increase testosterone concentrations in male great tits Horm. Behav. (IF 3.5) Pub Date : 2024-02-09 Ségolène Delaitre, Marcel E. Visser, Kees van Oers, Samuel P. Caro
Trees release Herbivore-Induced Plant Volatiles (HIPVs) into the air in response to damage inflicted by insects. It is known that songbirds use those compounds to locate their prey, but more recently the idea emerged that songbirds could also use those odours as cues in their reproductive decisions, as early spring HIPVs may contain information about the seasonal timing and abundance of insects. We
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Special Issue: Highlights of SBN 2022 Horm. Behav. (IF 3.5) Pub Date : 2024-02-05 Farrah N. Madison, Nora H. Prior, Brian C. Trainor
Abstract not available
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Experimentally elevated corticosterone does not affect bacteria killing ability of breeding female tree swallows (Tachycineta bicolor) Horm. Behav. (IF 3.5) Pub Date : 2024-02-04 David A. Chang van Oordt, Conor C. Taff, Monique A. Pipkin, Thomas A. Ryan, Maren N. Vitousek
The immune system can be modulated when organisms are exposed to acute or chronic stressors. Glucocorticoids (GCs), the primary hormonal mediators of the physiological stress response, are suspected to play a crucial role in immune modulation. However, most evidence of stress-associated immunomodulation does not separate the effects of glucocorticoid-dependent pathways from those of glucocorticoid-independent
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A hamster model for stress-induced weight gain Horm. Behav. (IF 3.5) Pub Date : 2024-02-01 Kevin M. Moran, Yvon Delville
This review addresses the translational relevance of animal models of stress and their effects on body weight. In humans, stress, whether chronic or acute, has often been associated with increased food intake and weight gain. In view of the current obesity epidemic, this phenomenon is especially relevant. Such observations contrast with reports with commonly used laboratory animals, especially rats
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Selective attention towards infants in nulliparous women across the menstrual cycle Horm. Behav. (IF 3.5) Pub Date : 2024-02-01 Sarah K.C. Holtfrerich, Esther K. Diekhof
Research in women showed that testosterone is associated with decreased selective attention towards infant stimuli, which can be compensated for by oxytocin administration. In theory, caregiving behavior is thought to be mediated by oxytocin. Oxytocin binds to dopaminergic neurons and thus supposedly motivates aspects of caregiving through its influence on dopaminergic transmission. Most previous studies
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Social environment and anogenital distance length phenotype interact to explain testosterone levels in a communally rearing rodent: Part 2: The female side Horm. Behav. (IF 3.5) Pub Date : 2024-01-31 Loreto A. Correa, Antonia Aspillaga-Cid, Cecilia León, Carolyn M. Bauer, Juan Ramírez-Estrada, Loren D. Hayes, Mauricio Soto-Gamboa, Luis A. Ebensperger
Testosterone is known as a “male” hormone; however, females also synthetize testosterone, which influences female sexual and aggressive behavior. In female vertebrates, as in males, testosterone levels can vary seasonally. However, female testosterone levels may also be related with female anogenital distance (AGD) length phenotype (a proxy of prenatal androgen exposure), and the social group environment
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Leveraging the unique social organization of California mice to study circuit-specific effects of oxytocin on behavior Horm. Behav. (IF 3.5) Pub Date : 2024-01-27 Alyssa A. Lake, Brian C. Trainor
Oxytocin is a versatile neuropeptide that modulates many different forms of social behavior. Recent hypotheses pose that oxytocin enhances the salience of rewarding and aversive social experiences, and the field has been working to identify mechanisms that allow oxytocin to have diverse effects on behavior. Here we review studies conducted on the California mouse (Peromyscus californicus) that shed
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From pathology to pleasure: Reframing mechanistic studies on same-sex sexual behavior in primates Horm. Behav. (IF 3.5) Pub Date : 2024-01-25 Evan Cunningham, Marcela E. Benítez
Same-sex sexual behaviors (SSB) in primates have historically been studied as sexual perversions, evolutionary paradoxes, and hormone-driven pathologies. Researchers in recent decades have challenged these perspectives, yet some of the original biases still linger. In this paper, we examine how the study of endocrinological mechanisms in SSB has been influenced by the historical framework of pathology
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Social environment and anogenital distance length phenotype interact to explain testosterone levels in a communally rearing rodent: Part 1: The male side Horm. Behav. (IF 3.5) Pub Date : 2024-01-25 Loreto A. Correa, Antonia Aspillaga-Cid, Carolyn M. Bauer, Danna Silva-Álvarez, Cecilia León, Juan Ramírez-Estrada, Mauricio Soto-Gamboa, Loren D. Hayes, Luis A. Ebensperger
In vertebrates, male testosterone levels vary across the year being generally higher during the mating season relative to the offspring rearing season. However, male testosterone levels may also be associated with male anogenital distance (AGD) length (a proxy of prenatal androgen exposition), and influenced by the social group environment. In social species, it has been proposed that high levels of
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In your CORT: Corticosterone and its receptors in the brain underlie mate choosiness in female Cope's gray treefrogs (Hyla chrysoscelis) Horm. Behav. (IF 3.5) Pub Date : 2024-01-20 Mariana Rodriguez-Santiago, Annika Ruppert, Megan D. Gall, Kim Hoke, Mark A. Bee, Alexander T. Baugh
Selecting an attractive mate can involve trade-offs related to investment in sampling effort. Glucocorticoids like corticosterone (CORT) are involved in resolving energetic trade-offs. However, CORT is rarely studied in the context of mate choice, despite its elevated levels during reproductive readiness and the energetic transitions that characterize reproduction. Few systems are as well suited as
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Early life adversity accelerates hypothalamic drive of pubertal timing in female rats with associated enhanced acoustic startle Horm. Behav. (IF 3.5) Pub Date : 2024-01-18 Lauren Granata, Michaela Fanikos, Heather C. Brenhouse
Early life adversity in the form of childhood maltreatment in humans or as modeled by maternal separation (MS) in rodents is often associated with an earlier emergence of puberty in females. Earlier pubertal initiation is an example of accelerated biological aging and predicts later risk for anxiety in women, especially in populations exposed to early life trauma. Here we investigated external pubertal
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Hair cortisol and dehydroepiandrosterone and their associations with optimism and pessimism in older people Horm. Behav. (IF 3.5) Pub Date : 2024-01-08 Mariola Zapater-Fajarí, Isabel Crespo-Sanmiguel, Teresa Montoliu, Vanesa Hidalgo, Alicia Salvador
The cumulative negative effects of prolonged Hypothalamic-Pituitary-Adrenal axis (HPA axis) activation are associated with several age-related diseases. Some psychological traits such as optimism and pessimism have been shown to be related to both health and the stress response, although their relationship with the HPA axis is inconclusive. More stable HPA axis biomarkers, such as hair samples of cortisol
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Gender minority stress and diurnal cortisol profiles among transgender and gender diverse people in the United States Horm. Behav. (IF 3.5) Pub Date : 2024-01-07 L. Zachary DuBois, Jae A. Puckett, Dee Jolly, Sally Powers, Tian Walker, Debra A. Hope, Richard Mocarski, T. Zachary Huit, Brenna R. Lash, Natalie Holt, Allura Ralston, Makinna Miles, A. Capannola, Clove Tipton, Geeta Eick, Robert-Paul Juster
The field of behavioral neuroendocrinology has only begun to explore the lived experiences of transgender and gender diverse (TGD) people exposed to stigma. In light of escalating attacks and legislation targeting TGD people in the United States, it is crucial to examine the physiological pathways through which gender minority stressors become embodied, impact health, and contribute to health inequities
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Androgen receptors rapidly modulate non-breeding aggression in male and female weakly electric fish (Gymnotus omarorum) Horm. Behav. (IF 3.5) Pub Date : 2023-12-28 Guillermo Valiño, Kent Dunlap, Laura Quintana
The South American weakly electric fish, Gymnotus omarorum, displays territorial aggression year-round in both sexes. To examine the role of rapid androgen modulation in non-breeding aggression, we administered acetate cyproterone (CPA), a potent inhibitor of androgen receptors, to both male and females, just before staged agonistic interactions. Wild-caught fish were injected with CPA and, 30 min
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Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior Horm. Behav. (IF 3.5) Pub Date : 2023-12-22 Shannon N. Bennett, Austin B. Chang, Forrest D. Rogers, Parker Jones, Catherine Jensen Peña
Proper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across the lifespan impacts thyroid hormone signaling and anxiety disorders and depression have been associated with thyroid dysfunction (both hypo- and hyper-active). However, less is known about how stress during postnatal development impacts thyroid function and
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Beyond the binary: Characterizing the relationships between sex and neuropeptide receptor binding density measures in the rat brain Horm. Behav. (IF 3.5) Pub Date : 2023-12-21 Daphna Joel, Caroline J. Smith, Alexa H. Veenema
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Levonorgestrel maintains goal-directed behavior in habit-trained intact female rats Horm. Behav. (IF 3.5) Pub Date : 2023-12-14 Sarah VonDoepp, Zaidan Mohammed, Russell Dougherty, Ella Hilton-Vanosdall, Sam Charette, Adina Kraus, Sarah Van Horn, Adrianna Quirk, Donna Toufexis
Hormonal contraceptives are utilized by millions of women worldwide. However, it remains unclear if these powerful endocrine modulators may alter cognitive function. Habit formation involves the progression of instrumental learning as it goes from being a conscious goal-directed process to a cue-driven automatic habitual motor response. Dysregulated goal and/or habit is implicated in numerous psychopathologies
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Impact of continuous testosterone exposure on reproductive physiology, activity, and pain-related behavior in young adult female rats Horm. Behav. (IF 3.5) Pub Date : 2023-12-13 Rebecca M. Craft, Christyne M. Sewell, Tessa M. Taylor, Mai Suong Vo, Kristen Delevich, Michael M. Morgan
Testosterone may reduce pain in cisgender women and transgender men. Rodents can provide a useful model for investigating physiological effects of hormone therapy. To this end, continuous-release testosterone or blank (placebo) capsules were implanted s.c. into young adult female rats, and three weeks later rats were either ovariectomized or sham-ovariectomized. Testosterone treatment that mimicked
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Toward understanding the endocrine regulation of diverse facultative migration strategies Horm. Behav. (IF 3.5) Pub Date : 2023-12-06 Heather E. Watts, Jamie M. Cornelius
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Early life adversity reduces affiliative behavior with a stressed cagemate and leads to sex-specific alterations in corticosterone responses in adult mice Horm. Behav. (IF 3.5) Pub Date : 2023-12-08 Jocelyn M. Breton, Zoey Cort, Camila Demaestri, Madalyn Critz, Samuel Nevins, Kendall Downend, Dayshalis Ofray, Russell D. Romeo, Kevin G. Bath
Experiencing early life adversity (ELA) alters stress physiology and increases the risk for developing psychiatric disorders. The social environment can influence dynamics of stress responding and buffer and/or transfer stress across individuals. Yet, the impact of ELA on sensitivity to the stress of others and social behavior following stress is unknown. Here, to test the impact of ELA on social and
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Corrigendum to “Menstrual cycle and exogenous attention toward emotional expressions” [Horm. Behav. 146 (2022) 105259] Horm. Behav. (IF 3.5) Pub Date : 2023-12-08 F. Álvarez, U. Fernández-Folgueiras, C. Méndez-Bértolo, D. Kessel, L. Carretié
Abstract not available
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A mouse model of oral contraceptive exposure: Depression, motivation, and the stress response Horm. Behav. (IF 3.5) Pub Date : 2023-12-06 Kristen M. Schuh, Jabir Ahmed, Esther Kwak, Cecilia X. Xu, Tronjay T. Davis, Chloe B. Aronoff, Natalie C. Tronson
Hormonal contraceptives, including oral contraceptives (OCs), regulate hormonal cycles and broadly affect physiological processes, including stress responsivity. Whereas many users describe overall improved mood, up to 10 % of OC users experience adverse effects, including depression and anxiety. Given the link between regulation of hypothalamic-pituitary-adrenal (HPA) axis, stress exposure, and risk
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Attention-deficit/hyperactivity disorder and the menstrual cycle: Theory and evidence Horm. Behav. (IF 3.5) Pub Date : 2023-11-30 Ashley G. Eng, Urveesha Nirjar, Anjeli R. Elkins, Yancey J. Sizemore, Krystina N. Monticello, Madeline K. Petersen, Sarah A. Miller, Jordan Barone, Tory A. Eisenlohr-Moul, Michelle M. Martel
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that exhibits striking sex differences in symptoms, prevalence, and associated problems across development. Etiological factors and mechanisms underlying these sex differences remain one of the most understudied aspects of this disorder. The current paper seeks to provide a novel theoretical framework for understanding
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From grouping and cooperation to menstruation: Spiny mice (Acomys cahirinus) are an emerging mammalian model for sociality and beyond Horm. Behav. (IF 3.5) Pub Date : 2023-11-24 Brandon A. Fricker, Aubrey M. Kelly
While spiny mice are primarily used as a model for Type II diabetes and for studying complex tissue regeneration, they are also an emerging model for a variety of studies examining hormones, behavior, and the brain. We began studying the spiny mouse to take advantage of their highly gregarious phenotype to examine how the brain facilitates large group-living. However, this unique rodent can be readily
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Comparative analysis of gonadal hormone receptor expression in the postnatal house mouse, meadow vole, and prairie vole brain Horm. Behav. (IF 3.5) Pub Date : 2023-11-22 Katherine A. Denney, Melody V. Wu, Simón(e) D. Sun, Soyoun Moon, Jessica Tollkuhn
The socially monogamous prairie vole (Microtus ochrogaster) and promiscuous meadow vole (Microtus pennsylvanicus) are closely related, but only prairie voles display long-lasting pair bonds, biparental care, and selective aggression towards unfamiliar individuals after pair bonding. These social behaviors in mammals are largely mediated by steroid hormone signaling in the social behavior network (SBN)
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The role of sex hormones, oral contraceptive use, and its parameters on visuospatial abilities, verbal fluency, and verbal memory. Horm. Behav. (IF 3.5) Pub Date : 2023-11-17 Lisa-Marie Davignon,Alexandra Brouillard,Robert-Paul Juster,Marie-France Marin
Sex hormones can cross the blood-brain barrier and access brain regions underlying higher-order cognition. Containing synthetic sex hormones, oral contraceptives (OC) have been found to modulate visuospatial and verbal abilities, though inconsistencies have been found in the literature. Among possible explanations, certain OC use parameters (progestin androgenicity, synthetic hormone levels, duration
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Noise and light pollution elicit endocrine responses in urban but not forest frogs. Horm. Behav. (IF 3.5) Pub Date : 2023-11-16 Judith A H Smit,Riet Vooijs,Peter Lindenburg,Alexander T Baugh,Wouter Halfwerk
Urban areas are characterised by the presence of sensory pollutants, such as anthropogenic noise and artificial light at night (ALAN). Animals can quickly adapt to novel environmental conditions by adjusting their behaviour, which is proximately regulated by endocrine systems. While endocrine responses to sensory pollution have been widely reported, this has not often been linked to changes in behaviour
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Sex diversity in the 21st century: Concepts, frameworks, and approaches for the future of neuroendocrinology. Horm. Behav. (IF 3.5) Pub Date : 2023-11-16 Kristina O Smiley,Kathleen M Munley,Krisha Aghi,Sara E Lipshutz,Tessa M Patton,Devaleena S Pradhan,Tessa K Solomon-Lane,Simón E D Sun
Sex is ubiquitous and variable throughout the animal kingdom. Historically, scientists have used reductionist methodologies that rely on a priori sex categorizations, in which two discrete sexes are inextricably linked with gamete type. However, this binarized operationalization does not adequately reflect the diversity of sex observed in nature. This is due, in part, to the fact that sex exists across
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Characterization of social hierarchy formation and maintenance in same-sex, group-housed male and female C57BL/6 J mice. Horm. Behav. (IF 3.5) Pub Date : 2023-11-15 Hannah D Fulenwider,Yangmiao Zhang,Andrey E Ryabinin
Social hierarchies are a prevalent feature of all animal groups, and an individual's rank within the group can significantly affect their overall health, typically at the greatest expense of the lowest-ranked individuals, or omegas. These subjects have been shown to exhibit various stress-related phenotypes, such as increased hypothalamic-pituitary axis activity and increased amygdalar corticotropin-releasing
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A bird's eye view of the hippocampus beyond space: Behavioral, neuroanatomical, and neuroendocrine perspectives. Horm. Behav. (IF 3.5) Pub Date : 2023-11-15 Farrah N Madison,Verner P Bingman,Tom V Smulders,Christine R Lattin
Although the hippocampus is one of the most-studied brain regions in mammals, research on the avian hippocampus has been more limited in scope. It is generally agreed that the hippocampus is an ancient feature of the amniote brain, and therefore homologous between the two lineages. Because birds and mammals are evolutionarily not very closely related, any shared anatomy is likely to be crucial for
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Vasotocin but not isotocin is involved in the emergence of the dominant-subordinate status in males of the weakly electric fish, Gymnotus omarorum Horm. Behav. (IF 3.5) Pub Date : 2023-11-08 Paula Pouso, Álvaro Cabana, Virginia Francia, Ana Silva
The establishment of the dominant-subordinate status implies a clear behavioral asymmetry between contenders that arises immediately after the resolution of the agonistic encounter and persists during the maintenance of stable dominance hierarchies. Changes in the activity of the brain social behavior network (SBN) are postulated to be responsible for the establishment and maintenance of the dominant-subordinate
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Estradiol effects on an emotional interference task in adolescents with current and remitted depression Horm. Behav. (IF 3.5) Pub Date : 2023-11-01 Abigail J. Sullivan, Yu Sun Chung, Stephanie Novotny, C. Neill Epperson, Hedy Kober, Hilary P. Blumberg, James J. Gross, Kevin N. Ochsner, Godfrey Pearlson, Michael C. Stevens
Attentional biases to emotional stimuli are thought to reflect vulnerability for mood disorder onset and maintenance. This study examined the association between the endogenous sex hormone estradiol and emotional attentional biases in adolescent females with either current or remitted depression. Three groups of participants (mean age ± SD) completed the Emotional Interrupt Task: 1) 20 adolescent females
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Acute nicotine intake increases feeding behavior through decreasing glucagon signaling in dependent male and female rats Horm. Behav. (IF 3.5) Pub Date : 2023-11-04 Kokila Shankar, Jarryd Ramborger, Sélène Bonnet-Zahedi, Lieselot L.G. Carrette, Olivier George
Chronic use of nicotine is known to dysregulate metabolic signaling through altering circulating levels of feeding-related hormones, contributing to the onset of disorders like type 2 diabetes. However, little is known about the acute effects of nicotine on hormonal signaling. We previously identified an acute increase in food intake following acute nicotine, and we sought to determine whether this
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Considering hormones as sex- and gender-related factors in biomedical research: Challenging false dichotomies and embracing complexity Horm. Behav. (IF 3.5) Pub Date : 2023-10-31 Jennifer S. Williams, Michelle R. Fattori, Isabella R. Honeyborne, Stacey A. Ritz
The inclusion of sex and gender considerations in biomedicine has been increasing in light of calls from research and funding agencies, governmental bodies, and advocacy groups to direct research attention to these issues. Although the inclusion of both female and male participants is often an important element, overreliance on a female-male binary tends to oversimplify the interactions between sex-
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Participation of the nitric oxide pathway in lordosis induced by apelin-13 in female rats Horm. Behav. (IF 3.5) Pub Date : 2023-11-02 Ailyn Luna-Hernández, Marcos García-Juárez, Jonathan Palafox-Moreno, Berenice Téllez-Angulo, Raymundo Domínguez-Ordóñez, James G. Pfaus, Oscar González-Flores
The present study investigated the participation of the nitric oxide pathway in facilitating lordosis behavior induced by intrahypothalamic administration of apelin-13 in ovariectomized rats primed with estradiol benzoate (EB). The experiments involved the administration of a nitric oxide synthase inhibitor (L-NAME) or a nitric oxide-dependent, soluble guanylyl cyclase inhibitor (ODQ), and an inhibitor
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The effect of supraphysiological dose of nandrolone decanoate administration on the inflammatory, neurotrophin and behavioral response in adult and old male mice Horm. Behav. (IF 3.5) Pub Date : 2023-10-27 A. Zamir, T. Ben Zeev, C. Levi, O. Einstein, N.A. Ratamess, H. van Praag, J.R. Hoffman
This study examined the effect of 6 weeks of supraphysiological nandrolone decanoate (ND) administration in adult mice (7 months) on cognitive function and neuroinflammation during aging. Male C57BL/6 mice were randomized into ND (10 mg·kg−1·wk−1) or control (CTL) groups. Half of the mice were tested at a young (Y) age (ND-Y and CTL-Y), 1 week following final ND administration, while the remaining
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Sex differences in androgen receptor, estrogen receptor alpha, and c-Fos co-expression with corticotropin releasing factor expressing neurons in restrained adult mice Horm. Behav. (IF 3.5) Pub Date : 2023-10-27 Krystyna A. Rybka, Jennifer J. Lafrican, Zachary J. Rosinger, Deborah O. Ariyibi, Mecca R. Brooks, Jason S. Jacobskind, Damian G. Zuloaga
Gonadal hormone actions through androgen receptor (AR) and estrogen receptor alpha (ERα) regulate sex differences in hypothalamic-pituitary-adrenal (HPA) axis responsivity and stress-related behaviors. Here we tested whether corticotropin releasing factor (CRF) expressing neurons, which are widely known to regulate neuroendocrine and behavioral stress responses, co-express AR and ERα as a potential
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Chronic intranasal oxytocin increases acoustic eavesdropping and adult neurogenesis Horm. Behav. (IF 3.5) Pub Date : 2023-10-21 Patrick K. Monari, Zachary J. Herro, Jessica Bymers, Catherine A. Marler
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Prenatal testosterone synchrony in first-time parents predicts fathers' postpartum relationship quality Horm. Behav. (IF 3.5) Pub Date : 2023-10-19 Sofia I. Cárdenas, Winnie Tse, Gabriel León, Alice Kim, Kayla Tureson, Mark Lai, Darby E. Saxbe
There is evidence that men's testosterone levels decline across the transition to fatherhood and that this decline may reflect fathers' investment in the new family. There is also emerging evidence that cohabiting couples show synchrony or within-couple associations in testosterone levels during the perinatal period. Hormonal synchrony may act as a mechanism that supports fathers' biological preparation
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Deconstructing sex: Strategies for undoing binary thinking in neuroendocrinology and behavior Horm. Behav. (IF 3.5) Pub Date : 2023-10-19 Megan G. Massa, Krisha Aghi, M.J. Hill
The scientific community widely recognizes that “sex” is a complex category composed of multiple physiologies. Yet in practice, basic scientific research often treats “sex” as a single, internally consistent, and often binary variable. This practice occludes important physiological factors and processes, and thus limits the scientific value of our findings. In human-oriented biomedical research, the
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Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background Horm. Behav. (IF 3.5) Pub Date : 2023-10-07 Garret L. Ryherd, Averie L. Bunce, Haley A. Edwards, Nina E. Baumgartner, Elizabeth K. Lucas
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Lack of evidence for coevolution between oxytocin receptor N-terminal variants and monogamy in placental mammals Horm. Behav. (IF 3.5) Pub Date : 2023-10-06 Paola Cerrito, Jeffrey K. Spear
Oxytocin (OXT) is a neurohypophyseal hormone that influences a wide range of affiliative behaviors, such as pair-bonding and infant care, across mammals. The effects of OXT depend significantly on an adequate interaction with its receptor, OXTR. OXTR belongs to the G-protein coupled receptor family. The extracellular N-terminal domain of OXTR interacts with the linear C-terminal tail of OXT and is
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Urban and rural male song sparrows (Melospiza melodia) differ in territorial aggression and activation of vasotocin neurons in response to song challenge Horm. Behav. (IF 3.5) Pub Date : 2023-10-04 Kendra B. Sewall, Michelle L. Beck, Samuel J. Lane, Scott Davies
When living in urban habitats, ‘urban adapter’ species often show greater aggression toward conspecifics, yet we do not understand the mechanisms underlying this behavioral shift. The neuroendocrine system regulates socio-sexual behaviors including aggression and thus could mediate behavioral responses to urbanization. Indeed, urban male song sparrows (Melospiza melodia), which are more territorially