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Nutritional health Acta Physiol. (IF 6.3) Pub Date : 2024-03-16 Pontus B. Persson, Anja Bondke Persson
The UN General Assembly proclaimed 2016–2025 a Decade of Action on Nutrition, to address the enormous and ever-growing burden of malnutrition on the world's population. Did you know that malnutrition and related pathologies affect every country in the world? While, in 2022, approximately 390 million adults were underweight, 2.5 billion were overweight, with rising tendencies, and alarmingly high rates
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Unraveling the crosstalk between renin‐angiotensin system receptors Acta Physiol. (IF 6.3) Pub Date : 2024-03-16 Mariela M. Gironacci, Ezequiel Bruna‐Haupt
The renin‐angiotensin system (RAS) plays a key role in blood pressure regulation. The RAS is a complex interconnected system composed of two axes with opposite effects. The pressor arm, represented by angiotensin (Ang) II and the AT1 receptor (AT1R), mediates the vasoconstrictor, proliferative, hypertensive, oxidative, and pro‐inflammatory effects of the RAS, while the depressor/protective arm, represented
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Myalgic encephalomyelitis/chronic fatigue syndrome from current evidence to new diagnostic perspectives through skeletal muscle and metabolic disturbances Acta Physiol. (IF 6.3) Pub Date : 2024-03-14 Tiziana Pietrangelo, Stefano Cagnin, Danilo Bondi, Carmen Santangelo, Lorenzo Marramiero, Cristina Purcaro, Raphael Severino Bonadio, Ester Sara Di Filippo, Rosa Mancinelli, Stefania Fulle, Vittore Verratti, Xuanhong Cheng
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a demanding medical condition for patients and society. It has raised much more public awareness after the COVID‐19 pandemic since ME/CFS and long‐COVID patients share many clinical symptoms such as debilitating chronic fatigue. However, unlike long COVID, the etiopathology of ME/CFS remains a mystery despite several decades' research.
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Age‐related muscle atrophy? Mitofusin 2 the rescue Acta Physiol. (IF 6.3) Pub Date : 2024-03-11 Agustina Creus, David Sebastián
Sarcopenia, or the progressive loss of muscle mass and function associated with aging, is a fundamental contributor to disability and loss of autonomy in the elderly, leading to frailty and a decrease in the quality of life.1 Several molecular alterations have been proposed to contribute to the development of sarcopenia, such as increased inflammation, altered proteostasis, a decrease in motor unit
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Lipopolysaccharide exacerbates depressive‐like behaviors in obese rats through complement C1q‐mediated synaptic elimination by microglia Acta Physiol. (IF 6.3) Pub Date : 2024-03-11 Titikorn Chunchai, Thirathada Chinchapo, Jirapas Sripetchwandee, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
AimProlonged high‐fat diet (HFD) consumption has been shown to impair cognition and depression. The combined effects of HFD and lipopolysaccharide (LPS) administration on those outcomes have never been thoroughly investigated. This study investigated the effects of LPS, HFD consumption, and a combination of both conditions on microglial dysfunction, microglial morphological alterations, synaptic loss
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The effect of neuromuscular electrical stimulation on the human skeletal muscle transcriptome Acta Physiol. (IF 6.3) Pub Date : 2024-03-09 Johanna Flodin, Stefan M. Reitzner, Eric B. Emanuelsson, Carl Johan Sundberg, Paul Ackermann
AimThe influence on acute skeletal muscle transcriptomics of neuromuscular electrical stimulation (NMES), as compared to established exercises, is poorly understood. We aimed to investigate the effects on global mRNA‐expression in the quadriceps muscle early after a single NMES‐session, compared to the effects of voluntary knee extension exercise (EX), and to explore the discomfort level.MethodsGlobal
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Muscle physiology and its relations to the whole body in health and disease Acta Physiol. (IF 6.3) Pub Date : 2024-03-09 Kathrin Groeneveld
Over the past years, researchers increased awareness of the connection of muscle tissue to the rest of the human body and of the possibilities to tweak the muscles' metabolism in order to gain positive effects on whole body metabolism, energy balance, and immune system. Physiotherapists and doctors aim to find practical exercise guidelines for patients to follow for ideal treatment. To do so, much
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Sex differences in single neuron function and proteomics profiles examined by patch‐clamp and mass spectrometry in the locus coeruleus of the adult mouse Acta Physiol. (IF 6.3) Pub Date : 2024-03-09 Jingyun Lee, Zhong‐Min Wang, María Laura Messi, Carol Milligan, Cristina M. Furdui, Osvaldo Delbono
AimsThis study aimed to characterize the properties of locus coeruleus (LC) noradrenergic neurons in male and female mice. We also sought to investigate sex‐specific differences in membrane properties, action potential generation, and protein expression profiles to understand the mechanisms underlying neuronal excitability variations.MethodsUtilizing a genetic mouse model by crossing Dbhcre knock‐in
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Impairment of the adrenergic reserve associated with exercise intolerance in a murine model of heart failure with preserved ejection fraction Acta Physiol. (IF 6.3) Pub Date : 2024-03-04 Lukas Semmler, Tobias Jeising, Judith Huettemeister, Marc Bathe‐Peters, Konstantina Georgoula, Rashin Roshanbin, Paulina Sander, Shu Fu, David Bode, Felix Hohendanner, Burkert Pieske, Paolo Annibale, Gabriele G. Schiattarella, Christian U. Oeing, Frank R. Heinzel
AimExercise intolerance is the central symptom in patients with heart failure with preserved ejection fraction. In the present study, we investigated the adrenergic reserve both in vivo and in cardiomyocytes of a murine cardiometabolic HFpEF model.Methods12‐week‐old male C57BL/6J mice were fed regular chow (control) or a high‐fat diet and L‐NAME (HFpEF) for 15 weeks. At 27 weeks, we performed (stress)
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Mitochondrial fumarate promotes ischemia/reperfusion‐induced tubular injury Acta Physiol. (IF 6.3) Pub Date : 2024-02-27 Zuo‐Lin Li, Ming‐Min Huang, Meng‐Yao Yu, Di‐Fei Nie, Sha‐Li Fu, Jing‐Jing Di, Ting Lan, Bi‐Cheng Liu, Qiu‐Li Wu
AimMitochondrial dysfunction, a characteristic pathological feature of renal Ischemic/reperfusion injury (I/RI), predisposes tubular epithelial cells to maintain an inflammatory microenvironment, however, the exact mechanisms through which mitochondrial dysfunction modulates the induction of tubular injury remains incompletely understood.MethodsESI‐QTRAP‐MS/MS approach was used to characterize the
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Metabolic flexibility in postmenopausal women: Hormone replacement therapy is associated with higher mitochondrial content, respiratory capacity, and lower total fat mass Acta Physiol. (IF 6.3) Pub Date : 2024-02-26 A. S. Kleis‐Olsen, J. E. Farlov, E. A. Petersen, M. Schmücker, M. Flensted‐Jensen, I. Blom, A. Ingersen, M. Hansen, J. W. Helge, F. Dela, S. Larsen
AimTo investigate effects of hormone replacement therapy in postmenopausal women on factors associated with metabolic flexibility related to whole‐body parameters including fat oxidation, resting energy expenditure, body composition and plasma concentrations of fatty acids, glucose, insulin, cortisol, and lipids, and for the mitochondrial level, including mitochondrial content, respiratory capacity
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MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission Acta Physiol. (IF 6.3) Pub Date : 2024-02-24 Marina Cefis, Manon Dargegen, Vincent Marcangeli, Shima Taherkhani, Maude Dulac, Jean‐Philippe Leduc‐Gaudet, Dominique Mayaki, Sabah N. A. Hussain, Gilles Gouspillou
AimSarcopenia, the aging‐related loss of muscle mass and function, is a debilitating process negatively impacting the quality of life of affected individuals. Although the mechanisms underlying sarcopenia are incompletely understood, impairments in mitochondrial dynamics, including mitochondrial fusion, have been proposed as a contributing factor. However, the potential of upregulating mitochondrial
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Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice Acta Physiol. (IF 6.3) Pub Date : 2024-02-24 Agnieszka Kij, Anna Bar, Izabela Czyzynska‐Cichon, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Zuzanna Kurylowicz, Agnieszka Jasztal, Elzbieta Buczek, Anna Kurpinska, Joanna Suraj‐Prazmowska, Brygida Marczyk, Karolina Matyjaszczyk‐Gwarda, Andreas Daiber, Matthias Oelze, Maria Walczak, Stefan Chlopicki
AimProtein disulfide isomerases (PDIs) are involved in platelet aggregation and intravascular thrombosis, but their role in regulating endothelial function is unclear. Here, we characterized the involvement of vascular PDIA1 in angiotensin II (Ang II)‐induced endothelial dysfunction in mice.MethodsEndothelial dysfunction was induced in C57BL/6JCmd male mice via Ang II subcutaneous infusion, and PDIA1
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Chronic heart failure induces early defenestration of liver sinusoidal endothelial cells (LSECs) in mice Acta Physiol. (IF 6.3) Pub Date : 2024-02-23 Kamila Wojnar‐Lason, Urszula Tyrankiewicz, Agnieszka Kij, Anna Kurpinska, Patrycja Kaczara, Grzegorz Kwiatkowski, Natalia Wilkosz, Magdalena Giergiel, Marta Stojak, Marek Grosicki, Tasnim Mohaissen, Agnieszka Jasztal, Zuzanna Kurylowicz, Marek Szymonski, Izabela Czyzynska‐Cichon, Stefan Chlopicki
AimChronic heart failure (CHF) is often linked to liver malfunction and systemic endothelial dysfunction. However, whether cardio‐hepatic interactions in heart failure involve dysfunction of liver sinusoidal endothelial cells (LSECs) is not known. Here we characterize LSECs phenotype in early and end stages of chronic heart failure in a murine model.MethodsRight ventricle (RV) function, features of
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Multiple ions control astroglial excitability, or “Nein, Kalzium, ist NICHT alles” Acta Physiol. (IF 6.3) Pub Date : 2024-02-23 Alexei Verkhratsky, Christine R. Rose
Otto Loewi exclaimed “Ja, Kalzium, das ist alles” in 1959. This paradigm was written in stone for glial cells, for which Ca2+ signalling is considered paramount for excitability. Fancy cytosolic Ca2+probes, such as Quin-1 and Fura-2 introduced by Roger Tsien in early 1980 led to a remarkable boost in studies on neuroglia. For the first time, it became possible to monitor in real time cellular responses
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Sex differences in neuromuscular and biological determinants of isometric maximal force Acta Physiol. (IF 6.3) Pub Date : 2024-02-22 Gaia Giuriato, Maria Grazia Romanelli, Desirée Bartolini, Gianluca Vernillo, Anna Pedrinolla, Tatiana Moro, Martino Franchi, Elena Locatelli, Mehran Emadi Andani, Fabio Giuseppe Laginestra, Chiara Barbi, Gloria Fiorini Aloisi, Valentia Cavedon, Chiara Milanese, Elisa Orlandi, Tonia De Simone, Stefania Fochi, Cristina Patuzzo, Giovanni Malerba, Paolo Fabene, Massimo Donadelli, Anna Maria Stabile, Alessandra
Force expression is characterized by an interplay of biological and molecular determinants that are expected to differentiate males and females in terms of maximal performance. These include muscle characteristics (muscle size, fiber type, contractility), neuromuscular regulation (central and peripheral factors of force expression), and individual genetic factors (miRNAs and gene/protein expression)
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Transketolase drives the development of aortic dissection by impairing mitochondrial bioenergetics Acta Physiol. (IF 6.3) Pub Date : 2024-02-21 Chaoyun Wang, Li Zhang, Qinghua Zhang, Hui Zheng, Xi Yang, Weixing Cai, Qiuying Zou, Jingjing Lin, Lin Zhang, Lin Zhong, Xinyao Li, Yuqing Liao, Qin Liu, Liangwan Chen, Yumei Li
AimAortic dissection (AD) is a disease with rapid onset but with no effective therapeutic drugs yet. Previous studies have suggested that glucose metabolism plays a critical role in the progression of AD. Transketolase (TKT) is an essential bridge between glycolysis and the pentose phosphate pathway. However, its role in the development of AD has not yet been elucidated. In this study, we aimed to
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Pre-fusion motion state determines the heterogeneity of membrane fusion dynamics for large dense-core vesicles Acta Physiol. (IF 6.3) Pub Date : 2024-02-14 Renhao Xue, Enming Zhang, Yu Wang
In neuroendocrine cells, large dense-core vesicles (LDCVs) undergo highly regulated pre-fusion processes before releasing hormones via membrane fusion. Significant heterogeneity has been found for LDCV population based on the dynamics of membrane fusion. However, how the pre-fusion status impacts the heterogeneity of LDCVs still remains unclear. Hence, we explored pre-fusion determinants of heterogeneous
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Plasticity Acta Physiol. (IF 6.3) Pub Date : 2024-02-12 Pontus B. Persson, Anja Bondke Persson
The Oxford English Dictionary defines plasticity, when used in a life-science context, as the “adaptability of an organism to changes in its environment or differences between its various habitats”.1 When we mention plasticity in a biomedical context, however, due to the advances in research over the last decades, which have let us look at ever smaller building blocks of life, we usually do not refer
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Parkin is a critical player in the effects of caffeine over mitochondrial quality control pathways during skeletal muscle regeneration in mice Acta Physiol. (IF 6.3) Pub Date : 2024-02-05 M. V. Esteca, I. A. Divino, A. L. Vieira da Silva, M. B. Severino, R. R. Braga, E. R. Ropelle, F. M. Simabuco, I. L. Baptista
This study aimed to investigate the effects of caffeine on pathways associated with mitochondrial quality control and mitochondrial capacity during skeletal muscle regeneration, focusing on the role of Parkin, a key protein involved in mitophagy.
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How can paternal obesity impair memory processes in offspring? Acta Physiol. (IF 6.3) Pub Date : 2024-02-05 E. C. Gavioli, E. D. da Silva Junior
In this issue of Acta Physiologica, Mezo-Gonzalez and colleagues1 demonstrated significant neurochemical impairments in glutamate transmission and neuroplasticity in the hippocampus and frontal cortex of offspring born to obese fathers. Obesity is a global public health concern associated with an elevated risk of numerous adverse medical, mental, and social consequences. According to the World Health
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Novel insights into an old story: Magnesium and vascular tone Acta Physiol. (IF 6.3) Pub Date : 2024-02-05 Jeanette A. Maier
The study by Kudryavtseva et al1 sheds new light on the mechanisms underlying the regulation of blood pressure by magnesium and supports the qualified health claim released by the FDA regarding the relationship between a reduced risk of high blood pressure and the content of magnesium in conventional foods and dietary supplements.2 Vascular tone results from the contractility of vascular smooth muscle
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The impact of microbiota and ketogenic diet interventions in the management of drug-resistant epilepsy Acta Physiol. (IF 6.3) Pub Date : 2024-02-05 Laura Diaz-Marugan, Andrina Rutsch, Angela M. Kaindl, Francesca Ronchi
Drug-resistant epilepsy (DRE) is a neurological disorder characterized by uncontrolled seizures. It affects between 10%–40% of the patients with epilepsy worldwide. Drug-resistant patients have been reported to have a different microbiota composition compared to drug-sensitive patients and healthy controls. Importantly, fecal microbiota transplantations (FMTs), probiotic and dietary interventions have
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SGLT2 inhibition promotes glomerular repopulation by cells of renin lineage in experimental kidney disease Acta Physiol. (IF 6.3) Pub Date : 2024-02-05 Loïs A. K. van der Pluijm, Angela Koudijs, Wendy Stam, Joris J. T. H. Roelofs, A. H. Jan Danser, Joris I. Rotmans, Kenneth W. Gross, Michael P. Pieper, Anton Jan van Zonneveld, Roel Bijkerk
Sodium glucose co-transporter-2 (SGLT2) inhibitors stimulate renal excretion of sodium and glucose and exert renal protective effects in patients with (non-)diabetic chronic kidney disease (CKD) and may as well protect against acute kidney injury (AKI). The mechanism behind this kidney protective effect remains unclear. Juxtaglomerular cells of renin lineage (CoRL) have been demonstrated to function
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Effects of 30 days bed rest and exercise countermeasures on PBMC bioenergetics Acta Physiol. (IF 6.3) Pub Date : 2024-01-31 F.-M. Buescher, M. T. Schmitz, T. Frett, J. Kramme, L. de Boni, E. M. Elmenhorst, E. Mulder, S. Moestl, K. Heusser, P. Frings-Meuthen, J. Jordan, J. Rittweger, D. Pesta
Altered mitochondrial function across various tissues is a key determinant of spaceflight-induced physical deconditioning. In comparison to tissue biopsies, blood cell bioenergetics holds promise as a systemic and more readily accessible biomarker, which was evaluated during head-down tilt bed rest (HDTBR), an established ground-based analog for spaceflight-induced physiological changes in humans.
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Exercise-inducible circulating extracellular vesicle irisin promotes browning and the thermogenic program in white adipose tissue Acta Physiol. (IF 6.3) Pub Date : 2024-01-30 Hongwei Shi, Xiaojing Hao, Yaqin Sun, Yating Zhao, Yue Wang, Xiaorui Cao, Zeen Gong, Shusen Ji, Jiayin Lu, Yi Yan, Xiuju Yu, Xiaomao Luo, Juan Wang, Haidong Wang
Exercise can reduce body weight and promote white fat browning, but the underlying mechanisms remain largely unknown. This study investigated the role of fibronectin type III domain-containing protein 5 (FNDC5)/Irisin, a hormone released from exercising muscle, in the browning of white fat in circulating extracellular vesicles (EVs).
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Does hypometabolism constrain innate immune defense? Acta Physiol. (IF 6.3) Pub Date : 2024-01-30 Karen L. Kadamani, Samantha M. Logan, Matthew E. Pamenter
Many animals routinely make energetic trade-offs to adjust to environmental demands and these trade-offs often have significant implications for survival. For example, environmental hypoxia is commonly experienced by many organisms and is an energetically challenging condition because reduced oxygen availability constrains aerobic energy production, which can be lethal. Many hypoxia-tolerant species
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Routing of Kv7.1 to endoplasmic reticulum plasma membrane junctions Acta Physiol. (IF 6.3) Pub Date : 2024-01-29 Clara Serrano-Novillo, Irene Estadella, María Navarro-Pérez, Anna Oliveras, Angela de Benito-Bueno, Paula G. Socuéllamos, Manel Bosch, María José Coronado, Daniel Sastre, Carmen Valenzuela, Christian Soeller, Antonio Felipe
The voltage-gated Kv7.1 channel, in association with the regulatory subunit KCNE1, contributes to the IKs current in the heart. However, both proteins travel to the plasma membrane using different routes. While KCNE1 follows a classical Golgi-mediated anterograde pathway, Kv7.1 is located in endoplasmic reticulum-plasma membrane junctions (ER-PMjs), where it associates with KCNE1 before being delivered
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The zebrafish atrioventricular canal: A model for mammalian AV node conduction and secondary or follower pacemaker activity Acta Physiol. (IF 6.3) Pub Date : 2024-01-25 W. R. Giles
1 BACKGROUND Sensitive, robust, and cost-efficient methods for studies leading to new insights into genetically-mediated heart rhythm disturbances and their treatments are continuing to be developed and refined. Examples include: (i) isolated myocytes obtained from specific heart chambers, (ii) pluripotent and patient-specific stem cell preparations, and (iii) selected ion channel signaling complexes
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Etonogestrel promotes respiratory recovery in an in vivo rat model of central chemoreflex impairment Acta Physiol. (IF 6.3) Pub Date : 2024-01-23 Tara A. Janes, Silvia Cardani, Jasmeen K. Saini, Silvia Pagliardini
The central CO2 chemoreflex is a vital component of respiratory control networks, providing excitatory drive during resting conditions and challenges to blood gas homeostasis. The retrotrapezoid nucleus is a crucial hub for CO2 chemosensitivity; its ablation or inhibition attenuates CO2 chemoreflexes and diminishes restful breathing. Similar phenotypes characterize certain hypoventilation syndromes
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Erythrocyte metabolism Acta Physiol. (IF 6.3) Pub Date : 2024-01-25 Panagiotis N. Chatzinikolaou, Nikos V. Margaritelis, Vassilis Paschalis, Anastasios A. Theodorou, Ioannis S. Vrabas, Antonios Kyparos, Angelo D'Alessandro, Michalis G. Nikolaidis
Our aim is to present an updated overview of the erythrocyte metabolism highlighting its richness and complexity. We have manually collected and connected the available biochemical pathways and integrated them into a functional metabolic map. The focus of this map is on the main biochemical pathways consisting of glycolysis, the pentose phosphate pathway, redox metabolism, oxygen metabolism, purine/nucleoside
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Moderate variations in the human diet impact the gut microbiota in humanized mice Acta Physiol. (IF 6.3) Pub Date : 2024-01-22 Marc Schoeler, Rima Chakaroun, Harald Brolin, Ingrid Larsson, Rosie Perkins, Hanns-Ulrich Marschall, Robert Caesar, Fredrik Bäckhed
Drastic diet interventions have been shown to promote rapid and significant compositional changes of the gut microbiota, but the impact of moderate diet variations is less clear. Here, we aimed to clarify the impact of moderate diet variations that remain within the spectrum of the habitual human diet on gut microbiota composition.
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Nitric oxide, endothelium-derived hyperpolarizing factor, and smooth muscle-dependent mechanisms contribute to magnesium-dependent vascular relaxation in mouse arteries Acta Physiol. (IF 6.3) Pub Date : 2024-01-23 Olga Kudryavtseva, Kristina S. Lyngsø, Boye L. Jensen, Henrik Dimke
Magnesium (Mg2+) is a vasorelaxant. The underlying physiological mechanisms driving this vasorelaxation remain unclear. Studies were designed to test the hypothesis that multiple signaling pathways including nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in endothelial cells as well as Ca2+ antagonization and TRPM7 channels in vascular smooth muscle cells mediate Mg2+-dependent
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The gut-lung axis and asthma susceptibility in early life Acta Physiol. (IF 6.3) Pub Date : 2024-01-22 Fariz G. Kahhaleh, Gabriela Barrientos, Melanie L. Conrad
Asthma is the most common chronic disease among children, with more than 300 million cases worldwide. Over the past several decades, asthma incidence has grown, and epidemiological studies identify the modernized lifestyle as playing a strong contributing role in this phenomenon. In particular, lifestyle factors that modify the maternal gut microbiome during pregnancy, or the infant microbiome in early
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The lipid droplet in cancer: From being a tumor-supporting hallmark to clinical therapy Acta Physiol. (IF 6.3) Pub Date : 2024-01-22 Yingfang Cui, Shuli Man, Jiejing Tao, Yu Liu, Long Ma, Lanping Guo, Luqi Huang, Changxiao Liu, Wenyuan Gao
Abnormal lipid metabolism, one of the hallmarks in cancer, has gradually emerged as a novel target for cancer treatment. As organelles that store and release excess lipids, lipid droplets (LDs) resemble “gears” and facilitate cancer development in the body.
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Molecular determinants and intracellular targets of taurine signalling in pancreatic islet β-cells Acta Physiol. (IF 6.3) Pub Date : 2024-01-20 Julie Turbitt, R. Charlotte Moffett, Lorraine Brennan, Paul R. V. Johnson, Peter R. Flatt, Neville H. McClenaghan, Andrei I. Tarasov
Despite its abundance in pancreatic islets of Langerhans and proven antihyperglycemic effects, the impact of the essential amino acid, taurine, on islet β-cell biology has not yet received due consideration, which prompted the current studies exploring the molecular selectivity of taurine import into β-cells and its acute and chronic intracellular interactions.
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Acute exercise-induced release of innate immune proteins via small extracellular vesicles changes with aerobic fitness and age Acta Physiol. (IF 6.3) Pub Date : 2024-01-20 Mee Chee Chong, Anup D. Shah, Ralf B. Schittenhelm, Anabel Silva, Patrick F. James, Sam Shi Xuan Wu, Jason Howitt
Physical exercise triggers the secretion of small extracellular vesicles (sEVs) into the circulation in humans, enabling signalling crosstalk between tissues. Exercise-derived EVs and their cargo have been proposed to mediate adaptations to exercise; however, our understanding of how exercise-derived EV protein cargo is modulated by factors such as aerobic fitness and age of an individual is currently
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Exercise influence on monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in the skeletal muscle: A systematic review Acta Physiol. (IF 6.3) Pub Date : 2024-01-19 José Antonio Benítez-Muñoz, Rocío Cupeiro, Jacobo Á. Rubio-Arias, Teresa Amigo, Domingo González-Lamuño
This review aims to systematically analyze the effect of exercise on muscle MCT protein levels and mRNA expression of their respective genes, considering exercise intensity, and duration (single-exercise session and training program) in humans and rodents, to observe whether both models offer aligned results. The review also aims to report methodological aspects that need to be improved in future studies
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IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels Acta Physiol. (IF 6.3) Pub Date : 2024-01-19 Siyu Tao, Paco Hulpiau, Larry E. Wagner, Katja Witschas, David I. Yule, Geert Bultynck, Luc Leybaert
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+-release channels with crucial roles in cell function. Current IP3R inhibitors suffer from off-target effects and poor selectivity towards the three distinct IP3R subtypes. We developed a novel peptide inhibitor of IP3Rs and determined its effect on connexin-43 (Cx43) hemichannels, which are co-activated by IP3R stimulation.
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Muscle fibre mitochondrial [Ca2+] dynamics during Ca2+ waves in RYR1 gain-of-function mouse Acta Physiol. (IF 6.3) Pub Date : 2024-01-19 Rhayanna B. Gaglianone, Bradley S. Launikonis
A fraction of the Ca2+ released from the sarcoplasmic reticulum (SR) enters mitochondria to transiently increase its [Ca2+] ([Ca2+]mito). This transient [Ca2+]mito increase may be important in the resynthesis of ATP and other processes. The resynthesis of ATP in the mitochondria generates heat that can lead to hypermetabolic reactions in muscle with ryanodine receptor 1 (RyR1) variants during the cyclic
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Keeping breathing in balance through hormonal modulation in respiratory control Acta Physiol. (IF 6.3) Pub Date : 2024-01-18 Nicholas J. Burgraff
The neurophysiological control of breathing is a complex and dynamic process with consistent robustness from the first to the last breaths of life. However, this robustness is complemented by a flexibility that enables mammals to adjust breathing rapidly and precisely in line with ever-changing behavioral, hormonal, and metabolic demands. A clear example of this flexibility is the ability of the respiratory
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Preload dependence in an animal model of mild heart failure with preserved ejection fraction (HFpEF) Acta Physiol. (IF 6.3) Pub Date : 2024-01-17 Jens C. B. Jacobsen, Irene H. Schubert, Karin Larsen, Dijana Terzic, Louise Thisted, Morten B. Thomsen
Heart Failure with preserved Ejection Fraction (HFpEF) is characterized by diastolic dysfunction and reduced cardiac output, but its pathophysiology remains poorly understood. Animal models of HFpEF are challenging due to difficulties in assessing the degree of heart failure in small animals. This study aimed at inducing HFpEF in a mouse model to probe preload-dependency.
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Loss of testosterone induces postprandial insulin resistance and increases the expression of the hepatic antioxidant flavin-containing monooxygenases in mice exposed to intermittent hypoxia Acta Physiol. (IF 6.3) Pub Date : 2024-01-17 Gauthier Ganouna-Cohen, François Marcouiller, Britanny Blachot-Minassian, Maud Demarest, Charles Joly Beauparlant, Arnaud Droit, Elise Belaidi, Aida Bairam, Vincent Joseph
We tested the hypothesis that low testosterone alters the effects of intermittent hypoxia (IH) on glucose homeostasis, hepatic oxidative stress, and transcriptomic profile in male mice.
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Muscular stress is equal when resistance exercise with blood flow restriction is matched in total work volume: A cross-sectional, cross-over study Acta Physiol. (IF 6.3) Pub Date : 2024-01-17 Koichi Okita, Masashi Omokawa, Shingo Takada, Tomoyasu Kadoguchi, Noriteru Morita, Takashi Yokota
We compared muscular metabolic stress during exercise performed at multiple intensities, from very low to moderate, with blood flow restriction (BFR) adjusted by the same work volume.
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Hyperpolarization-activated cyclic nucleotide-gated channel inhibitor in myocardial infarction: Potential benefits beyond heart rate modulation Acta Physiol. (IF 6.3) Pub Date : 2024-01-17 Adivitch Sripusanapan, Panat Yanpiset, Sirawit Sriwichaiin, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Myocardial infarction (MI) and its associated complications including ventricular arrhythmias and heart failure are responsible for a significant incidence of morbidity and mortality worldwide. The ensuing cardiomyocyte loss results in neurohormone-driven cardiac remodeling, which leads to chronic heart failure in MI survivors. Ivabradine is a heart rate modulation agent currently used in treatment
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Adult rats sired by obese fathers present learning deficits associated with epigenetic and neurochemical alterations linked to impaired brain glutamatergic signaling Acta Physiol. (IF 6.3) Pub Date : 2024-01-17 Carla Elena Mezo-González, Juan Antonio García-Santillán, Bertrad Kaeffer, Mathilde Gourdel, Mikaël Croyal, Francisco Bolaños-Jiménez
Offspring of obese mothers are at high risk of developing metabolic syndrome and cognitive disabilities. Impaired metabolism has also been reported in the offspring of obese fathers. However, whether brain function can also be affected by paternal obesity has barely been examined. This study aimed to characterize the learning deficits resulting from paternal obesity versus those induced by maternal
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Spatiotemporal development and the regulatory mechanisms of cardiac resident macrophages: Contribution in cardiac development and steady state Acta Physiol. (IF 6.3) Pub Date : 2024-01-17 Demeng Qin, Ying Zhang, Fang Liu, Xiang Xu, Haiqiang Jiang, Zhaoliang Su, Lin Xia
Cardiac resident macrophages (CRMs) are integral components of the heart and play significant roles in cardiac development, steady-state, and injury. Advances in sequencing technology have revealed that CRMs are a highly heterogeneous population, with significant differences in phenotype and function at different developmental stages and locations within the heart. In addition to research focused on
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Calcineurin inhibition, cardiovascular consequences, vascular resistance, and potential responses Acta Physiol. (IF 6.3) Pub Date : 2024-01-12 Friedrich C. Luft
To place the consequences of calcineurin inhibition in a cardiovascular context.
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Early consequences of the phospholamban mutation PLN-R14del+/− in a transgenic mouse model Acta Physiol. (IF 6.3) Pub Date : 2024-01-12 Claudia Maniezzi, Marem Eskandr, Chiara Florindi, Mara Ferrandi, Paolo Barassi, Elena Sacco, Valentina Pasquale, Angela S. Maione, Giulio Pompilio, Vivian Oliveira Nunes Teixeira, Rudolf A. de Boer, Herman H. W. Silljé, Francesco Lodola, Antonio Zaza
The heterozygous phospholamban (PLN) mutation R14del (PLN R14del+/−) is associated with a severe arrhythmogenic cardiomyopathy (ACM) developing in the adult. “Superinhibition” of SERCA2a by PLN R14del is widely assumed to underlie the pathogenesis, but alternative mechanisms such abnormal energy metabolism have also been reported. This work aims to (1) to evaluate Ca2+ dynamics and energy metabolism
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Branchial CO2 and ammonia excretion in crustaceans: Involvement of an apical Rhesus-like glycoprotein Acta Physiol. (IF 6.3) Pub Date : 2024-01-11 Alex R. Quijada-Rodriguez, Sandra Fehsenfeld, Anna-Maria Marini, Jonathan M. Wilson, Mikyla T. Nash, Maria Sachs, David W. Towle, Dirk Weihrauch
To determine whether the crustacean Rh1 protein functions as a dual CO2/ammonia transporter and investigate its role in branchial ammonia excretion and acid–base regulation.
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Subcellular physiology Acta Physiol. (IF 6.3) Pub Date : 2024-01-11 Pontus B. Persson, Anja Bondke Persson
Over the past decades, time and again, a new development, technique, or methodical approach in biology and biomedicine has been heralded as “breakthrough” or “revolutionary”: In contrast to disciplines such as physics and chemistry, biology had been postulated to have undergone a crisis1 in the late 19th/early 20th century, when “biologists […] tired of the purely descriptive nature of their science
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Lessons in waste management: Deciphering the dual role of Crustacean Rh1 protein in ammonia and CO2 excretion Acta Physiol. (IF 6.3) Pub Date : 2024-01-01 Alexander M. Clifford
In this issue of Acta Physioloigica, Quijada-Rodriguez and colleuges1 artfully combine empirical evidence with a suite of investigative tools to explore the dual capacity of Crustacean Rh1 (CmRh1) protein as a NH3 and CO2 channel in the European green crab (Carcinus maenas). Life is a complex balance of biochemical processes, and the regulation of ammonia and CO2 is critical for homeostasis in aquatic
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Insulin protein abundance matters in human pancreatic islets homeostasis Acta Physiol. (IF 6.3) Pub Date : 2023-12-22 Julie Vion-Chambrial, Karim Bouzakri
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of insulin-producing beta cells in pancreatic islets. The increase in T1D incidence leads to the need to better understand islet homeostasis for the development of new therapeutic strategies. Islet transplantation is a promising strategy to restore long-term normoglycaemia in people with T1D who have difficulty regulating
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Unraveling the complex connection between ketone bodies and insulin resistance Acta Physiol. (IF 6.3) Pub Date : 2023-12-22 Patrycja Puchalska
The relationship between ketone body metabolism and insulin resistance eludes discrete definition. Variables obscuring characterization include (i) physiological state in which hormone–fuel relationships are measured (fed, fasted, clamped); (ii) what is measured—for example, static ketone concentrations versus ketone body turnover, and whether acetoacetate is measured along with beta-hydroxybutyrate
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Vessels in motion Acta Physiol. (IF 6.3) Pub Date : 2023-12-13 Pontus B. Persson, Philipp Hillmeister, Ivo R. Buschmann, Anja Bondke Persson
In 1862, Auguste Gabriel Maurice Raynaud, in his doctoral thesis De l'asphyxie locale et de la gangrène symétrique des extrémités,1 described a medical condition in which a constriction of small arterial vessels, provoked by, for example, exposure to cold or stressful conditions, suddenly reduces arterial blood flow to end arterioles.2 Most often acral areas (fingers and toes, or, more rarely, the
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ERG potassium channels and T-type calcium channels contribute to the pacemaker and atrioventricular conduction in zebrafish larvae Acta Physiol. (IF 6.3) Pub Date : 2023-12-09 Jussep Salgado-Almario, Yillcer Molina, Manuel Vicente, Antonio Martínez-Sielva, Raúl Rodríguez-García, Pierre Vincent, Beatriz Domingo, Juan Llopis
Bradyarrhythmias result from inhibition of automaticity, prolonged repolarization, or slow conduction in the heart. The ERG channels mediate the repolarizing current IKr in the cardiac action potential, whereas T-type calcium channels (TTCC) are involved in the sinoatrial pacemaker and atrioventricular conduction in mammals. Zebrafish have become a valuable research model for human cardiac electrophysiology
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Physical exercise plays a role in rebalancing the bile acids of enterohepatic axis in non-alcoholic fatty liver disease Acta Physiol. (IF 6.3) Pub Date : 2023-12-01 Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Non-alcoholic fatty liver disease (NAFLD) is considered as one of the most common diseases of lipid metabolism disorders, which is closely related to bile acids disorders and gut microbiota disorders. Bile acids are synthesized from cholesterol in the liver, and processed by gut microbiota in intestinal tract, and participate in metabolic regulation through the enterohepatic circulation. Bile acids
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Climate change: The rise in atmospheric CO2 poses no risk for acid–base balance in humans Acta Physiol. (IF 6.3) Pub Date : 2023-12-01 Hans Malte, Tobias Wang
Physiological sciences play an essential part in identifying the best solutions urgently needed to mitigate the eminent threats of global climate change and to understand the consequences for life on Earth (https://www.physoc.org/policy/climate-change-and-health/climate-emergency-research-gaps-and-policy-priorities/). There is general consensus that increased emission of CO2 is responsible for the
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Hydrogen sulfide inhibits alveolar type II cell senescence and limits pulmonary fibrosis via promoting MDM2-mediated p53 degradation Acta Physiol. (IF 6.3) Pub Date : 2023-11-21 Xiu-Li Wang, Yi-Tong Xu, Shu-Li Zhang, Xiao-Yan Zhu, Hong-Xia Zhang, Yu-Jian Liu
Senescence of alveolar type II (AT2) cells is an important driver of pulmonary fibrosis. This study aimed to investigate whether and how dysregulation of hydrogen sulfide (H2S) production affected AT2 cell senescence, and then explored the effect of H2S on the communication between AT2 and fibroblasts.