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mtDNA regulates cGAS-STING signaling pathway in adenomyosis Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-15 Kun Wang, Yi Wen, Xianyun Fu, Shaobin Wei, Shidan Liu, Minmin Chen
In various hyperproliferative disorders, damaged mitochondria can release mitochondrial DNA (mtDNA) into the cytoplasm, activating the cGAS-STING signaling pathway and subsequent immune imbalances. Our previous research has demonstrated that hypoxia plays a role in the development of adenomyosis (AM) by inducing mitochondrial dysfunction. However, the precise involvement of the cGAS-STING signaling
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TIGAR reduces neuronal ferroptosis by inhibiting succinate dehydrogenase activity in cerebral ischemia Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-15 Xinxin Wang, Mei Li, Fan Wang, Guanghui Mao, Junchao Wu, Rong Han, Rui Sheng, Zhenghong Qin, Hong Ni
Ischemia Stroke (IS) is an acute neurological condition with high morbidity, disability, and mortality due to a severe reduction in local cerebral blood flow to the brain and blockage of oxygen and glucose supply. Oxidative stress induced by IS predisposes neurons to ferroptosis. TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits the intracellular glycolytic pathway to increase pentose
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Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine? Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-14 Barry Halliwell, Irwin Cheah
We propose that the diet-derived compound ergothioneine (ET) is an important nutrient in the human body, especially for maintenance of normal brain function, and that low body ET levels predispose humans to significantly increased risks of neurodegenerative (cognitive impairment, dementia, Parkinson's disease) and possibly other age-related diseases (including frailty, cardiovascular disease, and eye
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Redox organization of living systems Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-14 Dean P. Jones
Redox organization governs an underlying simplicity in living systems. Critically, redox reactions enable the essential characteristics of life: extraction of energy from the environment, use of energy to support metabolic and structural organization, use of dynamic redox responses to defend against environmental threats, and use of redox mechanisms to direct differentiation of cells and organ systems
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Corrigendum to “Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials” [Free Radic. Biol. Med. (2024) 215 25–36] Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-13 Cicero Jonas R. Benjamim, Leonardo S. Lopes da Silva, Vitor E. Valenti, Leonardo S. Gonçalves, Andrey A. Porto, Márcio Fernando Tasinafo Júnior, Jean-Philippe Walhin, David M. Garner, Bruno Gualano, Carlos R. Bueno Júnior
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Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-12 Linhai Wang, Shu Tian, Sisi Ruan, Jingjing Wei, Sijia Wei, Weiwei Chen, Hangcui Hu, Weiwei Qin, Yan Li, Hang Yuan, Jian Mao, Yan Xu, Jianping Xie
Parkinson's disease (PD) is a prevalent progressive and multifactorial neurodegenerative disorder. Cordycepin is known to exhibit antitumor, anti-inflammatory, antioxidative stress, and neuroprotective effects; however, few studies have explored the neuroprotective mechanism of cordycepin in PD. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we investigated the impact
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Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-12 Qianzhu Li, Jiaxin Kang, Ning Liu, Jiayi Huang, Xueya Zhang, Kemiao Pang, Shiwu Zhang, Mengyi Wang, Yajun Zhao, Shiyun Dong, Hongxia Li, Dechao Zhao, Fanghao Lu, Weihua Zhang
Anomalous vascular endothelium significantly contributes to various cardiovascular diseases. VE-cadherin plays a vital role in governing the endothelial barrier. Krüppel-like factor 4(KLF4), as a transcription factor, which binds the VE-cadherin promoter and enhances its transcription. Tumor necrosis factor receptor-associated factor 7 (TRAF7) is an E3 ubiquitin ligase that has been shown to modulate
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Changed regulation of granulocyte NADPH oxidase activity in the mouse model of obesity-induced type 2 diabetes mellitus Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-11 Irina V. Tikhonova, Alsu R. Dyukina, Andrei A. Grinevich, Elvira R. Shaykhutdinova, Valentina G. Safronova
NADPH oxidase is a target of hyperglycemia in type 2 diabetes mellitus (T2DM), which causes dysregulation of enzyme. Alterations in regulation of NADPH oxidase activity mediated receptor and non-receptor signaling in bone marrow granulocytes of mice with obesity-induced T2DM were studied. The animals fed high fat diet (516 kcal/100 g) for 16 weeks. NADPH oxidase-related generation of reactive species
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Reactive oxygen species augment contractile responses of saphenous artery in 10-15-day-old but not adult rats: Substantial role of NADPH oxidases Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-08 Anastasia A. Shvetsova, Margarita A. Khlystova, Yulia A. Makukha, Valentina S. Shateeva, Anna A. Borzykh, Dina K. Gaynullina, Olga S. Tarasova
Reactive oxygen species (ROS) produced by NADPH oxidases (NOX, a key source of ROS in vascular cells) are involved in the regulation of vascular tone, but this has been explored mainly for adult organisms. Importantly, the mechanisms of vascular tone regulation differ significantly in early postnatal ontogenesis and adulthood, while the vasomotor role of ROS in immature systemic arteries is poorly
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The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E −/− mice Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-08 Xin Mu, Shu-Jun Liu, Lei-Yin Zheng, Chenxi Ouyang, Ahmed M.E. Abdalla, Xin-Xin Wang, Kai Chen, Fei-Fei yang, Ning Meng
Oxidized low density lipoprotein (oxLDL)-induced endothelial oxidative damage promotes the development of atherosclerosis. Caveolae play an essential role in maintaining the survival and function of vascular endothelial cell (VEC). It is reported that the long coiled-coil protein NECC2 is localized in caveolae and is associated with neural cell differentiation and adipocyte formation, but its role
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Unveiling the antioxidant superiority of α-tocopherol: Implications for vitamin E nomenclature and classification Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-07 Hao Tian, Yi-Fang Li, Gen-Long Jiao, Wan-Yang Sun, Rong-Rong He
Since the discovery of tocopherols a century ago, α-tocopherol has been distinguished for its unique biological functions. In this study, we aim to elucidate the unique characteristics of α-tocopherol from a chemical perspective. Utilizing density functional theory (DFT) calculations, we evaluated the thermodynamic and kinetic properties of tocopherols, tocotrienols and their oxidation products. Our
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Glsirt1-mediated deacetylation of GlCAT regulates intracellular ROS levels, affecting ganoderic acid biosynthesis in Ganoderma lucidum Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-07 Jing Han, Lingshuai Wang, Xin Tang, Rui Liu, Liang Shi, Jing Zhu, Mingwen Zhao
Lysine acetylation is a reversible, dynamic protein modification regulated by lysine acetyltransferases and deacetylases. However, in Basidiomycetes, the extent of lysine acetylation of nonhistone proteins remains largely unknown. Recently, we identified the deacetylase sirt1 as a key regulator of the biosynthesis of ganoderic acid (GA), a key secondary metabolite of . To gain insight into the characteristics
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Chronic exposure to PM10 induces anxiety-like behavior via exacerbating hippocampal oxidative stress Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-06 Jie Cheng, Jian Sun, Rui Niu, Xiaoqing Wang, Guilin Hu, Fan Li, Kunrong Gu, Hao Wu, Yuanchun Pu, Fanqi Shen, Hao Hu, Zhenxing Shen
As one of the most environmental concerns, inhaled particulate matter (PM) causes numerous health problems. However, the associations between anxiety behavior and toxicity caused by PM have rarely been reported so far. To investigate the changes of behavior after PM exposure and to identify the potential mechanisms of toxicity, PM samples (with doses of 15 mg/kg and 30 mg/kg) were intratracheally instilled
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Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-04 Zheng Peng, Xiao-Jian Li, Yan Zhou, Jia-Tong Zhang, Qi Zhu, Jia-Qing Sun, Chun-Hua Hang, Wei Li, Qing-Rong Zhang, Zong Zhuang
Spontaneous subarachnoid hemorrhage (SAH), the third most common stroke subtype, is associated with high mortality and disability rates. Therefore, finding effective therapies to improve neurological function after SAH is critical. The objective of this study was to investigate the potential neuroprotective effects of hydrogen in the context of SAH, specifically, by examining its role in attenuating
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Cardiac Resolvin D2 ameliorates sepsis-induced cardiomyopathy via inhibiting Caspase-11/GSDMD dependent pyroptosis Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-02 Wen-wu Zhang, Shun-shun Wang, Yang-dong Ding, Xin-yi Wu, Ting Chen, Ye Gao, Sheng-wei Jin, Pu-hong Zhang
Sepsis-induced cardiomyopathy (SICM) is common complication in septic patients with a high mortality and is characterized by an abnormal inflammation response, which was precisely regulated by endogenous specialized pro-resolving mediators (SPMs). However, the metabolic changes of cardiac SPMs during SICM and the roles of SPMs subset in the development of SICM remain unknown. In this work, the SPMs
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Revising the nomenclature for vitamin E requires agreement on its vitamin function Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-01 Alexander Montoya-Arroyo, Jan Frank
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Overexpression of cat2 restores antioxidant properties and production traits in degenerated strains of Volvariella volvacea Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-03-01 Jianing Zhu, Wenpei Wang, Wanhe Sun, Yuanxi Lei, Qiangfei Tan, Gahong Zhao, Jianmin Yun, Fengyun Zhao
Strain degeneration is an important factor hindering the development of the edible fungus industry. Strain degeneration is associated with the excessive accumulation of reactive oxygen species (ROS) . Catalase (CAT), an important antioxidant enzyme, can promote the clearance of ROS. In this study, the gene of was first cloned into an overexpression plasmid via homologous recombination. Finally, through
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Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-27 Mariana Nepomuceno, Paloma Monllor, Maria Jose Cardells, Artemis Ftara, Maria Magallon, Francisco Dasí, Mari Carmen Badia, Jose Viña, Ana Lloret
Carrying an allele 4 of the apolipoprotein E (ApoE) is the best-established genetic risk factor to develop Alzheimer's disease (AD). Fifty percent of ApoE4/4 individuals develop the disease at 70 years of age. ApoE3/4 carriers have a lower risk of developing the disease, still 50% of them suffer AD at around 80 years. In a previous study we showed that healthy young individuals, who had a parent with
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Allogeneic platelet-rich plasma inhibits ferroptosis in promoting wound repair of type 2 diabetic ulcers Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-25 Danlian Zhou, Qiu Liang, Xiuyu Ge, Jing Xu
Increasing evidence has revealed the emerging role of ferroptosis in the pathophysiology of type 2 diabetes mellitus (T2DM) and its complications. Platelet-rich plasma (PRP) has been demonstrated to facilitate the healing of T2DM ulcers. However, the mechanism by which PRP repairs T2DM ulcers remains unclear. Here, we sought to investigate the interaction between PRP and ferroptosis in repairing T2DM
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Vitamin E: Not only a single stereoisomer Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-23 M. Eggersdorfer, K. Schmidt, S. Péter, J. Richards, B. Winklhofer-Roob, A. Hahn, U. Obermüller-Jevic
The recent publication by Azzi and colleagues puts forth the argument that only -α-tocopherol should be considered as vitamin E from a physiological point of view. They base their argument primarily on the assertion that only this form has been used to treat stark vitamin E deficiency in humans (known as AVED, or Ataxia with Vitamin E Deficiency). Azzi et al. also argue that other chemically similar
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Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-23 Cicero Jonas R. Benjamim, Leonardo S. Lopes da Silva, Vitor E. Valenti, Leonardo S. Gonçalves, Andrey A. Porto, Márcio Fernando Tasinafo Júnior, Jean-Philippe Walhin, David M. Garner, Bruno Gualano, Carlos R. Bueno Júnior
A systematic review with meta-analysis was completed to study the effects of dietary inorganic nitrate (NO) oral ingestion from vegetables and salts on blood pressure responses during and following exercise. NO is a hypotensive agent with the potential to reduce blood pressure peaks during exercise and amplify exercise-induced hypotensive effects. Several randomized and controlled trials have investigated
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Systemic oxidative stress may be associated with reduced IgG antibody titers against SARS-CoV-2 in vaccinated kidney transplant recipients: A post-hoc analysis of the RECOVAC-IR observational study Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-22 Larissa E. van Eijk, Arno R. Bourgonje, A. Lianne Messchendorp, Marian L.C. Bulthuis, Marjan Reinders-Luinge, Berber Doornbos-van der Meer, Johanna Westra, Wilfred F.A. den Dunnen, Jan-Luuk Hillebrands, Jan-Stephan F. Sanders, Harry van Goor
Coronavirus disease 2019 (COVID-19) poses an increased risk for severe illness and suboptimal vaccination responses in patients with kidney disease, in which oxidative stress may be involved. Oxidative stress can be reliably measured by determining circulating free thiols (R–SH, sulfhydryl groups), since R–SH are rapidly oxidized by reactive species. In this study, we aimed to examine the association
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Therapeutic effect of mitochondrial transplantation on burn injury Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-22 Zhen Li, Xinhui Cao, Zuohao Liu, Fen Wu, Changjun Lin, Chun-Ming Wang
As mitochondrial damage or dysfunction is commonly observed following burn injuries, we investigated whether mitochondrial transplantation (MT) can result in therapeutic benefits in the treatment of burns. Human immortalized epidermal cells (HaCaT) and Kunming mice were used to establish a heat-injured cell model and a deep partial-thickness skin burn animal model, respectively. The cell model was
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Aging hallmarks, biomarkers, and clocks for personalized medicine: (re)positioning the limelight Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-21 M, ., , C, r, i, s, t, i, n, a, , P, o, l, i, d, o, r, i
The rapidly increasing aging prevalence, complexity, and heterogeneity pose the scientific and medical communities in front of challenges. These are delivered by gaps between basic and translational research, as well as between clinical practice guidelines to improve survival and absence of evidence on personalized strategies to improve functions, wellbeing and quality of life. The triumphs of aging
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Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-17 Yalei Cao, Zirun Jin, Yu Xi, Jianxing Cheng, Zishui Fang, Qiancheng Zhao, Jiaming Weng, Jun Zhu, Yanlin Tang, Zhe Zhang, Hui Jiang
Diabetes mellitus (DM) is a widespread metabolic disease presenting with various complications, including spermatogenic dysfunction. However, the underlying mechanisms are still unclear. Ferroptosis, a novel type of programmed cell death, is associated with much metabolic diseases. Here, we investigated the role of ferroptosis in spermatogenic dysfunction of streptozotocin (STZ)-induced type 1 diabetic
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Corrigendum to “Drug screening identifies aldose reductase as a novel target for treating cisplatin-induced hearing loss” [Free Radic. Biol. Med. 210 (2024) 430–447] Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-17 Yaqi Liao, Huanyu Mao, Xian Gao, Hailiang Lin, Wenyan Li, Yan Chen, Huawei Li
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Single exposure to anesthesia/surgery in neonatal mice induces cognitive impairment in young adult mice Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-16 Songhua Zhou, Xiaoyu Cui, Jie Chen, Manli Luo, Wen Ouyang, Jianbin Tong, Zhongcong Xie, Yuan Le
The effects of a solitary neonatal exposure to anesthesia plus surgery (anesthesia/surgery) on cognitive function and the underlying mechanism in developing brains remains largely undetermined. We, therefore, set out to investigate the impact of single exposure to anesthesia/surgery in neonatal mice. Six-day-old male and female mice received abdominal surgery under 3% sevoflurane plus 50% oxygen for
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Benzoylaconitine: A promising ACE2-targeted agonist for enhancing cardiac function in heart failure Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-16 Qi-qiang Zhang, Qing-shan Chen, Fei Feng, Xiang Cao, Xiao-fei Chen, Hai Zhang
Benzoylaconitine is a natural product in the treatment of cardiovascular disease. However, its pharmacological effect, direct target protein, and molecular mechanisms for the treatment of heart failure are unclear. In this study, benzoylaconitine inhibited Ang II-induced cell hypertrophy and fibrosis in rat primary cardiomyocytes and rat fibroblasts, while attenuating cardiac function and cardiac remodeling
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The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-15 Yulin Ye, Limin Liu, Zelin Feng, Yifei Liu, Junming Miao, Xinyue Wei, Huizhen Li, Jie Yang, Xiaocang Cao, Jingwen Zhao
Ulcerative colitis (UC) is a chronic gastrointestinal disease that can be managed with 5-aminosalicylic acid (5-ASA), the standard treatment for UC. However, the effectiveness of 5-ASA is not always optimal. Our study revealed that despite 5-ASA treatment, cells continued to experience excessive ferroptosis, which may hinder mucosal healing in UC and limit the success of this treatment approach in
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β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-15 Haoyu Wang, Jingchun Liu, Zihui Zhang, Jiaxin Peng, Zhi Wang, Lian Yang, Xinqi Wang, Siyuan Hu, Li Hong
The exploration of drugs derived from natural sources holds significant promise in addressing current limitations in ovarian cancer (OC) treatments. While previous studies have highlighted the remarkable anti-cancer properties of the natural compound β-sitosterol (SIT) across various tumors, its specific role in OC treatment remains unexplored. This study aims to investigate the anti-tumor activity
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Coenzyme Q deficiency in endothelial mitochondria caused by hypoxia; remodeling of the respiratory chain and sensitivity to anoxia/reoxygenation Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-15 Karolina Dominiak, Lukasz Galganski, Adrianna Budzinska, Wieslawa Jarmuszkiewicz
This study examined the effects of hypoxia on coenzyme Q (Q) levels and mitochondrial function in EA. hy926 endothelial cells, shedding light on their responses to changes in oxygen levels. Chronic hypoxia during endothelial cell culture reduced Q synthesis by reducing hydroxy-methylglutaryl-CoA reductase (HMGCR) levels via hypoxia-inducible factor 1α (HIF1α), leading to severe Q deficiency. In endothelial
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Sorafenib extends the lifespan of C. elegans through mitochondrial uncoupling mechanism Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-14 Lu-Yao Zheng, Yan-Xin Da, Xiu Luo, Xiao Zhang, Zhi-Jie Sun, De-Li Dong
Sorafenib is a targeted anticancer drug in clinic. Low-dose sorafenib has been reported to activate AMPK through inducing mitochondrial uncoupling without detectable toxicities. AMPK activation has been the approach for extending lifespan, therefore, we investigated the effect of sorafenib on lifespan and physical activity of and the underlying mechanisms. In the present study, we found that the effect
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An upstream open reading frame (5′-uORF) links oxidative stress to translational control of ALCAT1 through phosphorylation of eIF2α Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-13 Jun Zhang, Yuguang Shi
Acyl-CoA:lysocardiolipin acyltransferase 1 (ALCAT1) is an enzyme that promotes mitochondrial dysfunction by catalyzing pathological remodeling of cardiolipin. Upregulation of ALCAT1 protein expression by oxidative stress is implicated in the pathogenesis of age-related metabolic diseases, but the underlying molecular mechanisms remain elusive. In this study, we identified a highly conserved upstream
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Vitamin E discussion forum. Can only α-tocopherol be called vitamin E, or also other tocochromanols? Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-13 Mariya Mykhalkiv, Olha Denefil, Oksana Boyarchuk
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Alpha-ketoglutaric acid attenuates oxidative stress and modulates mitochondrial dynamics and autophagy of spleen in a piglet model of lipopolysaccharide-induced sepsis Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-10 Guangmang Liu, Jiajia Lu, Weixiao Sun, Gang Jia, Hua Zhao, Xiaoling Chen, Jing Wang
Alpha-ketoglutaric acid (2-ketoglutaric acid or 2-oxoglutaric acid, AKG), a crucial intermediate in the tricarboxylic acid cycle, is pivotal in animal antioxidative process. The purpose of this study was to investigate whether AKG has the efficacy to mitigate spleen oxidative stress in lipopolysaccharide (LPS)-induced sepsis piglets through the modulation of mitochondrial dynamics and autophagy. Utilizing
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Novel perfluorocarbon-based oxygenation therapy alleviates Post-SAH hypoxic brain injury by inhibiting HIF-1α Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-10 Zheng Peng, Qing-Song Ye, Xiao-Jian Li, De-Yuan Zheng, Yan Zhou, Chun-Hua Hang, Jin-Hui Wu, Wei Li, Zong Zhuang
In comparison to other stroke types, subarachnoid hemorrhage (SAH) is characterized by an early age of onset and often results in poor prognosis. The inadequate blood flow at the site of the lesion leads to localized oxygen deprivation, increased level of hypoxia-inducible factor-1α (HIF-1α), and triggers inflammatory responses and oxidative stress, ultimately causing hypoxic brain damage. Despite
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Supplementation of nicotinamide mononucleotide diminishes COX-2 associated inflammatory responses in macrophages by activating kynurenine/AhR signaling Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-08 Jing Liu, Wenxuan Hou, Zhaoyun Zong, Yuling Chen, Xiaohui Liu, Ran Zhang, Haiteng Deng
Cyclooxygenase-2 (COX-2) is an inducible enzyme responsible for prostaglandin synthesis during inflammation and immune responses. Our previous results show that NAD level decreased in activated macrophages while nicotinamide mononucleotide (NMN) supplementation suppressed the inflammatory responses via restoring NAD level and downregulating COX-2. However, whether NMN downregulates COX-2 in mouse model
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Sterile inflammation induces vasculopathy and chronic lung injury in murine sickle cell disease Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-08 Kevin R. Rarick, Keguo Li, Ru-Jeng Teng, Xigang Jing, Dustin P. Martin, Hao Xu, Deron W. Jones, Neil Hogg, Cheryl A. Hillery, Guilherme Garcia, Billy W. Day, Stephen Naylor, Kirkwood A. Pritchard Jr.
Murine sickle cell disease (SCD) results in damage to multiple organs, likely mediated first by vasculopathy. While the mechanisms inducing vascular damage remain to be determined, nitric oxide bioavailability and sterile inflammation are both considered to play major roles in vasculopathy. Here, we investigate the effects of high mobility group box-1 (HMGB1), a pro-inflammatory damage-associated molecular
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Corrigendum to “NADPH oxidases mediate a cellular “memory” of angiotensin II stress in hypertensive cardiac hypertrophy” [Free Radic. Biol. Med. 65 (2013) 897–907] Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-07 Hong-Xia Wang, Hui Yang, Qiu-Yue Han, Nan Li, Xue Jiang, Cui Tian, Jie Du, Hui-Hua Li
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Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-06 Le-le Zhang, Ke Ding, Shi-shi Liao, Yi-guo Zhang, Hui-yang Liao, Rong Chen, Qing-tao Meng
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Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-06 Yanan Sun, Menghan Sha, Yu Qin, Juan Xiao, Wei Li, Shufang Li, Suhua Chen
Exposure to bisphenol A (BPA) during gestation leads to fetal growth restriction (FGR), whereby the underlying mechanisms remain unknown. Here, we found that FGR patients showed higher levels of BPA in the urine, serum, and placenta; meanwhile, trophoblast ferroptosis was observed in FGR placentas, as indicated by accumulated intracellular iron, impaired antioxidant molecules, and increased lipid peroxidation
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Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-05 Li Jiang, Hao Zheng, Moe Ishida, Qinying Lyu, Shinya Akatsuka, Yashiro Motooka, Kotaro Sato, Yoshitaka Sekido, Kae Nakamura, Hiromasa Tanaka, Kenji Ishikawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, Shinya Toyokuni
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Mitochondria: A new member involved in stem cell senescence. An extended commentary on "Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches by Mas-Bargues C. [Free Radic. Biol. Med. (2023) Nov 1;208:657–671. doi:10.1016/j.freeradbiomed.2023.09.019] Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-30 Matilde Alique, Cristina Mas-Bargues
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Met-Exo attenuates mitochondrial dysfunction after hepatic ischemia-reperfusion injury in rats by modulating AMPK/SIRT1 signaling pathway Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-30 Chenxi Piao, Yue Wang, Xiangyu Lu, Tao Liu, Yajun Ma, Yuepeng Li, Jiantao Zhang, Hongbin Wang
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Sulforaphane impedes mitochondrial reprogramming and histone acetylation in polarizing M1 (LPS) macrophages Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-30 Sheyda Bahiraii, Martin Brenner, Wolfram Weckwerth, Elke H. Heiss
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Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-30 Christine Gran Neurauter, Marco Pannone, Mirta Mittelstedt Leal de Sousa, Wei Wang, Anna Kuśnierczyk, Luisa Luna, Pål Sætrom, Katja Scheffler, Magnar Bjørås
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Ambient particulate matter exposure induces ferroptosis in hippocampal cells through the GSK3B/Nrf2/GPX4 pathway Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-28 Jianxiong Gui, Lingman Wang, Jie Liu, Hanyu Luo, Dishu Huang, Xiaoyue Yang, Honghong Song, Ziyao Han, Linxue Meng, Ran Ding, Jiaxin Yang, Li Jiang
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BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1 Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-02 Shuting Li, Yiyi Zhuang, Yue Ji, Xiaowen Chen, Liying He, Sijia Chen, Yating Luo, Lingyu Shen, Jing Xiao, Huizhen Wang, Congwei Luo, Fenfen Peng, Haibo Long
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Corrigendum to “Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis” [Free Radic.Biol.Med. 211C (2024) 127 – 144] Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-02 Yanan Sun, Menghan Sha, Yu Qin, Juan Xiao, Wei Li, Shufang Li, Suhua Chen
Abstract not available
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The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-02 Chaoran Jia, Yulun Wu, Feng Gao, Wei Liu, Na Li, Yao Chen, Luguo Sun, Shuyue Wang, Chunlei Yu, Yongli Bao, Zhenbo Song
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Targeting ZIP8 mediated ferroptosis as a novel strategy to protect against the retinal pigment epithelial degeneration Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-02 Ziling Liu, Jianguo Huang, Deshuang Li, Chuanhe Zhang, Huan Wan, Bing Zeng, Yao Tan, Fuhua Zhong, Hongxia Liao, MuYun Liu, Zhe-Sheng Chen, Chang Zou, Dongcheng Liu, Bo Qin
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Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-02-01 Peiyan Yang, Hui Li, Mingjun Sun, Xinxin Guo, Yinghao Liao, Mohan Hu, Ping Ye, Ran Liu
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ULP-2 SUMO protease regulates UPRmt and mitochondrial homeostasis in Caenorhabditis elegans Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-30 Lirin Michaeli, Eyal Spector, Simon Haeussler, Cátia A. Carvalho, Hanna Grobe, Ulrike Bening Abu-Shach, Hen Zinger, Barbara Conradt, Limor Broday
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Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-26 Qiwei He, Tiantian Yu, Junxiong Chen, Jianli Liang, Dongni Lin, Kaihao Yan, Zijing Xie, Yuqi Song, Zhenzhou Chen
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Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-29 Xiaowen Liu, Huamei Cai, Liang Peng, Hongli Ma, Yun Yan, Weixia Li, Jing Zhao
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Exercise couples mitochondrial function with skeletal muscle fiber type via ROS-mediated epigenetic modification Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-29 Jialin Li, Ziyi Zhang, Hai Bo, Yong Zhang
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Targeting ERS-mitophagy in hippocampal neurons to explore the improvement of memory by tea polyphenols in aged type 2 diabetic rats Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-28 Wenjuan Feng, Chenhui Lv, Le Cheng, Xin Song, Xuemin Li, Haoran Xie, Shuangzhi Chen, Xi Wang, Lushan Xue, Cheng Zhang, Jie Kou, Lili Wang, Haifeng Zhao
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A preventative role of nitrate for hypoxia-induced intestinal injury Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-26 Yifan Xu, Yunqiong Sa, Chunmei Zhang, Jinsong Wang, Qianqian Shao, Jia Liu, Songlin Wang, Jian Zhou
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Acetylation of mtHSP70 at Lys595/653 affecting its interaction between GrpEL1 regulates glioblastoma progression via UPRmt Free Radical Bio. Med. (IF 7.4) Pub Date : 2024-01-26 Bixi Gao, Zongqi Wang, Kun Dai, Yunjiang Wang, Longyuan Li, Guangzhao Li, Xiaowang Niu, Xiang Li, Zhengquan Yu, Zhong Wang, Gang Chen