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LncRNA Meg3-mediated regulation of the Smad pathway in atRA-induced cleft palate Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-22 Xiaozhuan Liu; Yuwei Zhang; Lijun Shen; Zhidong He; Yao Chen; Ning Li; Xiuli Zhang; Tingting Zhang; Suhua Gao; Haodi Yue; Zhitao Li; Zengli Yu
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The unreliability of the reliability criteria in the estimation of QSAR for skin sensitivity: a pun or a reliable law? Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-20 Andrey A. Toropov; Alla P. Toropova
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Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-19 Max Epstein; Karan Bali; Thomas J. Piggot; A. Christopher Green; Christopher M. Timperley; Mike Bird; John E.H. Tattersall; Isabel Bermudez; Philip C. Biggin
Organophosphorus nerve agents (NAs) are the most lethal chemical warfare agents and have been used by state and non-state actors since their discovery in the 1930s. They covalently modify acetylcholinesterase, preventing the breakdown of acetylcholine (ACh) with subsequent loss of synaptic transmission, which can result in death. Despite the availability of several antidotes for OPNA exposure, none
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Changes in the renal function after acute mercuric chloride exposure in the rat are associated with renal vascular endothelial dysfunction and proximal tubule NHE3 inhibition Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-18 João Vitor dos Anjos Vieira; Vinicius Bermond Marques; Luiza Valli Vieira; Renato de Oliveira Crajoinas; Maria Heloisa Massola Shimizu; Antonio Carlos Seguro; Maria Tereza Weitzel Dias Carneiro; Adriana Castello Costa Girardi; Dalton Valentim Vassallo; Leonardo dos Santos
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Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-04 Abhinandan Chowdhury; Christina N. Zdenek; James S. Dobson; Lachlan A. Bourke; Raul Soria; Bryan G. Fry
Species within the viperid genus Macrovipera are some of the most dangerous snakes in the Eurasian region, injecting copious amounts of potent venom. Despite their medical importance, the pathophysiological actions of their venoms have been neglected. Particularly poorly known are the coagulotoxic effects and thus the underlying mechanisms of lethal coagulopathy. In order to fill this knowledge gap
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Urine proteomic analysis reveals alterations in heme/hemoglobin and aminopeptidase metabolism during Lonomia obliqua venom-induced acute kidney injury Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-17 Pamela Zanon; SabrinaBeal Pizzato; RafaelLopesda Rosa; PaulaBarros Terraciano; JoaoAlfredo Moraes; WalterOrlando Beys-da-Silva; Luc,lia Santi; JonhR. Yates; EduardoPandolfi Passos; Christina Barja-Fidalgo; JorgeAlmeida Guimaraes; Markus Berger
Aims Accidental contact with the Lonomia obliqua caterpillar is a common event in southern Brazil. Envenomed victims present consumption coagulopathy, which can evolve to acute kidney injury (AKI). In the present study, we searched for AKI biomarkers and changes in molecular pathway signatures through urine proteomic analysis. Methodology: Male Wistar rats were injected with L. obliqua venom (1.5 mg/kg
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Cellular viability and death biomarkers enables the evaluation of ocular irritation using the bovine corneal opacity and permeability assay Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-06 Z. Xie; K. Ye; S.H. Chen; L. Liu; L.C. He; J. Sang; H. Meng; R. Kuang
The BCOP assay is used in the identification of chemicals that cause no ocular irritation or serious damage. However, this method has not been found to adequately discriminate between mild from moderate ocular irritation (category 2A/2B), based upon the animal data. In this study, we aimed to establish methods for discerning ocular irritation by chemicals. We used the BCOP assay and the fluorescence
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The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-08 Jianchun Zhu; Yang Li; Jinghui Liang; Jingxin Li; Kai Huang; Jing Li; Chuanyong Liu
Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-inflammatory properties, but there is no evidence regarding its effects on VCR-induced
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Refinement of health-based guidance values for cadmium in the French population based on modelling Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-10 Stéphane Leconte; Christophe Rousselle; Laurent Bodin; François Clinard; Géraldine Carne
In France, part of the population is overexposed to cadmium by the diet. In our work, we first revised the tolerable daily intake (TDI) of 0.36 μg Cd.kg bw.d.−1 proposed by the European Food Safety Authority (EFSA), derived from effects on kidneys and based on the critical urinary Cd concentration of 1.0 μg Cd.g−1 creatinine for humans. After reviewing the epidemiological data on Cd toxicity published
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Therapeutic measures for sulfur mustard-induced ocular injury Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-10 Ariel Gore; Tamar Kadar; Shlomit Dachir; Vered Horwitz
The use of sulfur mustard (SM) in global terrorism is still a relevant threat to both civilian population and military personnel. Casualties exposed to SM may present mild, moderate or severe acute ocular lesions followed by a complete ocular resolution, chronic lesions or re-emerged ocular pathologies after a latent period. Current treatment for SM-induced ocular injury is based mainly on the clinical
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An in vitro study on the transport and phase II metabolism of the mycotoxin alternariol in combination with the structurally related gut microbial metabolite urolithin C Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-06 Francesco Crudo; Amelia Barilli; Pedro Mena; Bianca Maria Rotoli; Daniele Del Rio; Chiara Dall’Asta; Luca Dellafiora
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Subchronic exposure to acrylamide caused behaviour disorders and related pathological and molecular changes in rat cerebellum Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-06 Ying Liu; Dandan Yan; Yiqi Wang; Xing Zhang; Na Wang; Yang Jiao; Hong Yan
Acrylamide (ACR) is a neurotoxin with moderate acute toxicity. Significant level of ACR exists in diet and drinking water. Occupational exposure causes motor function impairment, but the underlying mechanisms remain poorly defined. This study aims to explore whether microtubule-associated protein tau phosphorylation, excessive activation of protein kinase RNA-like endoplasmic reticulum kinase (PERK)
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Glutathione is a potential therapeutic target for acrolein toxicity in the cornea Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-06 Suneel Gupta; Sabeeh Kamil; Prashant R. Sinha; Jason T. Rodier; Shyam S. Chaurasia; Rajiv R. Mohan
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Predicting the reproductive toxicity of chemicals using ensemble learning methods and molecular fingerprints Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-06 Huawei Feng; Li Zhang; Shimeng Li; Lili Liu; Tianzhou Yang; Pengyu Yang; Jian Zhao; Isaiah Tuvia Arkin; Hongsheng Liu
Reproductive toxicity endpoints are a significant safety concern in the assessment of the adverse effects of chemicals in drug discovery. Computational models that can accurately predict a chemical's toxic potential are increasingly pursued to replace traditional animal experiments. Thus, ensemble learning models were built to predict the reproductive toxicity of compounds. Our ensemble models were
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Impact of Updated BMD Modeling Methods on Perchlorate and Chlorate Assessments of Human Health Hazard Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-08 Lynne T. Haber; Rita S. Schoeny; Bruce C. Allen
Several exposure limits for perchlorate have been developed based on an early key event, inhibition of radioactive iodide uptake (RAIU) by the thyroid. These assessments have used a variety of definitions of the point of departure. The current assessment revisited the modeling for inhibition of RAIU, using state of the science methods. Bayesian hierarchical modeling was used to account for the repeated
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Depletion of serotonin relieves concanavalin A-induced liver fibrosis in mice by inhibiting inflammation, oxidative stress, and TGF-β1/Smads signaling pathway Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-08 Qing Pang; Hao Jin; Yong Wang; Mengnan Dai; Shuangchi Liu; Yi Tan; Huichun Liu; Zheng Lu
Serotonin exerts important functions in several liver pathophysiological processes. In this study, we investigated the role of serotonin in concanavalin A (Con A)-induced liver fibrosis (LF) in mice and the underlying mechanisms. To establish the mouse model of LF, mice of wild-type (WT) and tryptophan hydroxylase 1 (Tph1) knockout (serotonin depletion) received Con A for 8 successive weeks. Degree
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Tissue-specific expression and activity of cytochrome P450 1A and 3A in rainbow trout (Oncorhynchus mykiss) Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-08 Viktoriia Burkina; Galia Zamaratskaia; Sidika Sakalli; Pham Thai Giang; Vladimir Zlabek; Martin Krøyer Rasmussen
Piscine cytochrome P450 (CYP) enzymes play an important role in the metabolism of xenobiotics. Xenobiotics often act as inducers of CYP1A1 and CYP3A expression and activity in fish. We compared constitutive mRNA expression of CYP1A1, CYP3A27, and CYP3A45 and catalytic activity of CYP1A (7-ethoxyresorufin-O-deethylation, EROD) and CYP3A-like (benzyloxy-4-trifluoromethylcoumarin-O-debenzyloxylation,
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Adult female rats perinatally exposed to perfluorohexane sulfonate (PFHxS) and a mixture of endocrine disruptors display increased body/fat weights without a transcriptional footprint in fat cells Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-30 Cecilie Nethe Ramskov Tetzlaff; Louise Ramhøj; Aurélie Lardenois; Marta Axelstad; Bertrand Evrard; Frédéric Chalmel; Camilla Taxvig; Terje Svingen
Obesity is a complex disease with many causes, including a possible role for environmental chemicals. Perfluorohexane sulfonate (PFHxS) is one of many per- and polyfluoroalkyl substances (PFASs) frequently detected in humans and it is suspected to be an obesogenic compound. We examined the potential long-term effects of PFHxS on metabolic parameters in rats after developmental exposure to 0.05, 5 or
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Key Event-Informed Risk Models for Benzene-induced Acute Myeloid Leukaemia Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-08 Colin M. North; A. Robert Schnatter; Martijn Rooseboom; Neslihan Aygun Kocabas; Abigail Dalzell; Stephen D. Williams
Occupational exposure to benzene at levels of 10 ppm or more has been associated with increased risk of acute myeloid leukaemia (AML). The mode of action (MOA) for AML development leading to mortality is anticipated to include multiple earlier key events, which can be observed in hematotoxicity and genetic toxicity in peripheral blood of exposed workers. Prevention of these early events would lead
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Effect of 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione, isolated from Averrhoa carambola L. (Oxalidaceae) roots, on advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice Toxicol. Lett. (IF 3.569) Pub Date : 2021-01-07 Zheng Ni; Xing Lin; Qingwei Wen; Kintoko; Shijun Zhang; Jianchun Huang; Xiaohui Xu; Renbin Huang
The roots of Averrhoa carambola L. (Oxalidaceae) have a long history of medical use in traditional Chinese medicine for treating diabetes and diabetic nephropathy. 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione (DMDD) was isolated from the tuberous roots of Averrhoa carambola L. The purpose of this study was to investigate the beneficial effect of DMDD on the advanced glycation end-product-mediated
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TP53-induced glycolysis and apoptosis regulator (TIGAR) ameliorates lysosomal damage in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-mediated mouse model of Parkinson’s disease Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-24 Jianbin Ge; Hongyan Lin; Jie Yang; QiQi Li; Jingsi Zhou; Zhenghong Qin; Feng Wu
The progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) correlates with rupture of lysosome in Parkinson’s disease (PD). It has been found that TP53-induced glycolysis and apoptosis regulator (TIGAR) has been attributed to the regulation of metabolic pathways and neuroprotective effect. In the present study, we showed in a mouse model that 1-methyl-4-phenyl-1
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Involvement of a novel regulatory cascade consisting of SET-H3K18ac/H3K27ac-53BP1 in Cr(VI)-induced malignant transformation of 16HBE cells Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-25 Zhihong Chen; Jiacheng Zhong; Xiaohu Ren; Wei Liu; Desheng Wu; Chongyang Chen; Haiyan Huang; Xinfeng Huang; Yungang Liu; Jianjun Liu
Hexavalent chromium (Cr(VI)) is a well-established human carcinogen with DNA damaging effects. Recently we established a Cr(VI)-induced malignant transformation model from a human bronchial epithelial (16HBE) cell line, and in the transformed (16HBE-T) cells reduced levels of 53BP1 (critical for DNA repair) and the acetylated histone H3K18/27 (H3K18/27ac) were observed. In 16HBE-T cells SET (a multifunctional
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Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-25 Tatsuya Ohkawara; Naoto Okubo; Osamu Maehara; Jun Nishihira; Hiroshi Takeda
Overdose use of acetaminophen (APAP) often occurs a severe liver injury, and its liver injury is lethal in some cases. Macrophage migration inhibitory factor (MIF) is expressed in a variety of cells and has multifunctional roles. However, the role of MIF in APAP-induced liver injury has not been fully investigated. In this study, we investigated whether treatment with (S,R)-3-(4-hydroxyphenil)-4,5
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Interesterified fat consumption since gestation decreases striatal dopaminergic targets levels and gdnf impairing locomotion of adult offspring Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-24 Lívia Ferraz D’avila; Verônica Tironi Dias; Laura Hautrive Milanesi; Karine Roversi; Fabíola Trevizol; Luana Haselein Maurer; Tatiana Emanuelli; Marilise Escobar Burger; Hecson Jesser Segat
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In vitro human skin decontamination efficacy of MOF-808 in decontamination lotion following exposure to the nerve agent VX Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-25 Andreas Larsson; Johanna Qvarnström; Sandra Lindberg; Elisabeth Wigenstam; Linda Öberg; Robin Afshin Sander; Susanne Johansson; Anders Bucht; Lina Thors
Metal-organic frameworks (MOFs) have shown promising properties for removal of chemical warfare agents, in particular for material decontamination and functionalized fabrics. The MOF-properties could also be beneficial for skin decontamination, especially when exposed to highly toxic and low volatile nerve agents. In such exposures, efficient decontamination is crucial for adequate medical management
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Exposure to traffic-generated air pollution promotes alterations in the integrity of the brain microvasculature and inflammation in female ApoE-/- mice Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-26 Anna Adivi; JoAnn Lucero; Nicholas Simpson; Jacob D. McDonald; Amie K. Lund
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Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-24 Zdeněk Fišar; Kamil Musílek; Ondřej Benek; Lukáš Hroch; Lucie Vinklářová; Monika Schmidt; Jana Hroudová; Jiří Raboch
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Effect of PM10 on pulmonary immune response and fetus development Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-07 Eun-Jung Park; Cheolho Yoon; Ji-Seok Han; Gwang-Hee Lee; Dong-Wan Kim; Eun-Jun Park; Hyun-Ji Lim; Min-Sung Kang; Hyoung-Yun Han; Hyun-Joo Seol; Kwang Pyo Kim
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A proposal for a new in vitro method for direct classification of eye irritants by cytotoxicity test – Preliminary study Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-07 Daniel Krakowian; Dominika Gądarowska; Anna Daniel-Wójcik; Inga Mrzyk
None of the in vitro method are suitable for directly classifying of a substance as an eye irritant (category 2). They can classify substance as category 1 (serious eye damage) or as “no category” (not requiring classification). The aim of this study was to develop a new method for direct classification of a substance as category 2. Cytotoxicity Assay to Assess Eye Irritation (CEI) was performed on
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A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-05 Zhengxi Wei; Yuhong Fang; Maya L. Gosztyla; Andrew J. Li; Wenwei Huang; Christopher A. LeClair; Anton Simeonov; Dingyin Tao; Menghang Xia
Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic peptides containing lysine or cysteine residues. To improve assay throughput
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Gender differences in acute toxicity, toxicokinetic and tissue distribution of amphotericin B liposomes in rats Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-09 Dong Wang; Wei Zhang; Jie-Xi Ju; Lu-Jia Wang; Ru-Yu Huang; Yan-Fang Xu; Hai-Lin Zhang; Jin-Long Qi
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A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-09 Ajay Yadav; Mazia Amber; Denis Zosen; Nils Anders Labba; Eva Henriette Willemijn Huiberts; Johanna Samulin Erdem; Fred Haugen; Hanne Friis Berntsen; Shanbeh Zienolddiny; Ragnhild Elisabeth Paulsen; Erik Ropstad; Lisa Connolly; Steven Verhaegen
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Cigarette smoke affects ESCRT-mediated vacuolar activity in Saccharomyces cerevisiae Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-09 Arnab Maiti; Nabanita Saha; Aditya Shukla; Srimonti Sarkar; Alok Kumar Sil
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Urinary microRNAs miR-15b and miR-30a as novel noninvasive biomarkers for gentamicin-induced acute kidney injury Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-05 B. Sun; Z. Qu; G.L. Cheng; Y.W. Yang; Y.F. Miao; X.G. Chen; X.B. Zhou; B. Li
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Inhibition of human UDP-glucuronosyltransferase enzyme by belinostat: Implications for drug-drug interactions Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-05 Xiaoyu Wang; Zhe Wang; Zhen Wang; Xiuyuan Chen; Hang Yin; Lili Jiang; Jun Cao; Yong Liu
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Evaluating the effect of ozone in UV induced skin damage Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-03 Francesca Ferrara; Erika Pambianchi; Brittany Woodby; Nicolo’ Messano; Jean-Philippe Therrien; Alessandra Pecorelli; Rita Canella; Giuseppe Valacchi
Air pollution represents one of the main risks for both environment and human health. The rapid urbanization has been leading to a continuous release of harmful manmade substances into the atmosphere which are associated to the exacerbation of several pathologies. The skin is the main barrier of our body against the external environment and it is the main target for the outdoor stressors. Among the
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Cadmium causes hepatopathy by changing the status of DNA methylation in the metabolic pathway Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-15 Chenghui Ren; Longfei Ren; Jun Yan; Zhongtian Bai; Lei Zhang; Honglong Zhang; Ye Xie; Xun Li
Toxicity caused by the heavy metal Cadmium leads to liver diseases; this finding has generated interest among researchers. We detected DNA methylation using Whole Genome Bisulfite Sequencing (WGBS) to study the relationship between Cadmium exposure and liver damage. Forty-eight Sprague-Dawley rats were randomly divided into six groups, and given normal saline or 2.5, 5, 10, 20, and 40 mg/kg body weight
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Repeated low-dose exposures to sarin disrupted the homeostasis of phospholipid and sphingolipid metabolism in guinea pig hippocampus Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-27 Meng Shi; Shikun Deng; Yalan Cui; Xuejun Chen; Tong Shi; Liangcai Song; Ruihua Zhang; Yi Zhang; Jianfu Xu; Jingjing Shi; Chen Wang; Liqin Li
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Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice Toxicol. Lett. (IF 3.569) Pub Date : 2020-12-05 Nga T. Nguyen; Kuo Du; Jephte Y. Akakpo; David S. Umbaugh; Hartmut Jaeschke; Anup Ramachandran
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Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-25 Jiangxia Du; Guanqun Li; Liyu Jiang; Xiaochen Zhang; Zhifei Xu; Hao Yan; Ziye Zhou; Qiaojun He; Xiaochun Yang; Peihua Luo
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Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-27 Dustyn A. Barnette; Mary A. Schleiff; Arghya Datta; Noah Flynn; S. Joshua Swamidass; Grover P. Miller
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Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-24 Aleksandra Popov Aleksandrov; Ivana Mirkov; Dina Tucovic; Jelena Kulas; Marina Ninkov; Milena Kataranovski
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Human variability in glutathione-S-transferase activities, tissue distribution and major polymorphic variants: Meta-analysis and implication for chemical risk assessment Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-12 Franca Maria Buratti; Keyvin Darney; Susanna Vichi; Laura Turco; Emma Di Consiglio; Leonie S. Lautz; Camille Béchaux; Jean-Lou Christian Michel Dorne; Emanuela Testai
The input into the QIVIVE and Physiologically-Based kinetic and dynamic models of drug metabolising enzymes performance and their inter-individual differences significantly improve the modelling performance, supporting the development and integration of alternative approaches to animal testing. Bayesian meta-analyses allow generating and integrating statistical distributions with human in vitro metabolism
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Anticoagulant Micrurus venoms: Targets and neutralization Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-14 Daniel Dashevsky; Melisa Bénard-Valle; Edgar Neri-Castro; Nicholas J. Youngman; Christina N. Zdenek; Alejandro Alagón; José A. Portes-Junior; Nathaniel Frank; Bryan G. Fry
Snakebite is a neglected tropical disease with a massive global burden of injury and death. The best current treatments, antivenoms, are plagued by a number of logistical issues that limit supply and access in remote or poor regions. We explore the anticoagulant properties of venoms from the genus Micrurus (coral snakes), which have been largely unstudied, as well as the effectiveness of antivenom
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Comparison of the biological impact of aerosol of e-vapor device with MESH® technology and cigarette smoke on human bronchial and alveolar cultures Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-18 Albert Giralt; Anita R Iskandar; Florian Martin; Elisa Moschini; Tomasso Serchi; Athanasios Kondylis; Diego Marescotti; Patrice Leroy; Laura Ortega-Torres; Shoaib Majeed; Celine Merg; Keyur Trivedi; Emmanuel Guedj; Stefan Frentzel; Nikolai V. Ivanov; Manuel C Peitsch; Arno C Gutleb; Julia Hoeng
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Cardiac effect induced by Crotalus durissus cascavella venom: Morphofunctional evidence and mechanism of action Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-22 Letícia O. Simões; Quiara L. Alves; Samuel B. Camargo; Fênix A. Araújo; Viviane R.S. Hora; Rafael L.C. Jesus; Breno C. Barreto; Simone G. Macambira; Milena B.P. Soares; Cássio S. Meira; Márcio C. Aguiar; Ricardo. D. Couto; Bruno Lomonte; José Evaldo Menezes-Filho; Jader S. Cruz; Marcos A. Vannier-Santos; Luciana L. Casais-e-Silva; Darizy.F. Silva
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Inter-phenotypic differences in CYP2C9 and CYP2C19 metabolism: Bayesian meta-regression of human population variability in kinetics and application in chemical risk assessment Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-21 Nadia Quignot; Witold Więcek; Leonie Lautz; Jean-Lou Dorne; Billy Amzal
Quantifying variability in pharmacokinetics (PK) and toxicokinetics (TK) provides a science-based approach to refine uncertainty factors (UFs) for chemical risk assessment. In this context, genetic polymorphisms in cytochromes P450 (CYPs) drive inter-phenotypic differences and may result in reduction or increase in metabolism of drugs or other xenobiotics. Here, an extensive literature search was performed
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JUUL e-liquid exposure elicits cytoplasmic Ca2+ responses and leads to cytotoxicity in cultured airway epithelial cells Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-27 Rui Zhang; Myles M. Jones; Ronna E. Dornsife; Tongde Wu; Vijay Sivaraman; Robert Tarran; Rob U. Onyenwoke
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Time-course transcriptome analysis of lungs from mice exposed to ricin by intratracheal inoculation Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-21 Zhouguang Jiao; Sha Li; Duo Su; Changjiao Gan; Xiaodong Zhao; Bo Gao; Yefeng Qiu; Yajun Song; Dongsheng Zhou; Lingfei Hu; Huiying Yang
In this study, a ricin toxin (RT)-induced pulmonary intoxication model was established in mice by intratracheal-delivered RT at a dose of 2× LD50. Based on this model, the histopathological evaluation of the lungs at 24 h and 48 h post-exposure was executed, and the genome-wide transcriptome of the lungs at 4, 12, 24 and 48 h post-exposure was analyzed. Histopathological analysis showed that a large
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The potential diagnostic and therapeutic applications of exosomes in drug-induced liver injury Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-28 Lanlan Zhao; Yuezhi Wang; Yu Zhang
Drug-induced liver injury (DILI) has gradually become a global public medical problem, which can be caused by more than 1000 currently available drugs. Unfortunately, the diagnosis and treatment of DILI are limited and imperfect. Exosomes can be secreted by a variety of cells and tissues in the body, rich in cell-type specific proteins, nucleic acids and lipids, which has been widely studied as an
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An R-shiny application to calculate optimal designs for single substance and interaction trials in dose response experiments Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-21 T. Holland-Letz; A. Kopp-Schneider
Background and objective Optimal experimental design theory proposes choosing specific settings in experimental trials in order to maximize the precision of the resulting parameter estimates. In dose response experiments, this corresponds to choosing the optimal dose levels for every available observation, and can be applied both to singular dose-response relationships and to interaction experiments
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Gas6 or Mer deficiency ameliorates silica-induced autophagosomes accumulation in mice lung Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-21 Wei Li; Li Xie; Jixuan Ma; Man Cheng; Lieyang Fan; Yiju Xu; Bin Wang; Weihong Chen
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Effect of superabsorbent polymers (SAP) and metal organic frameworks (MOF) wiping sandwich patch on human skin decontamination and detoxification in vitro Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-14 Yachao Cao; Xiaoying Hui; Howard I. Maibach
Most chemical warfare agents partition rapidly into stratum corneum (SC) and subsequently slowly diffuse through – or are retained in the membrane. Since chemicals can interact with SC components during the process, skin decontamination poses a challenging yet important problem. To address these issues, we have developed a new method in combination with wet and dry decon technologies with new materials
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Metabolism and pharmacokinetics of pharmaceuticals in cats (Felix sylvestris catus) and implications for the risk assessment of feed additives and contaminants Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-27 L.S. Lautz; M.Z. Jeddi; F. Girolami; C. Nebbia; J.L.C.M. Dorne
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Estragole DNA adduct accumulation in human liver HepaRG cells upon repeated in vitro exposure Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-12 Shuo Yang; Sebastiaan Wesseling; Ivonne M.C.M. Rietjens
Accumulation of N2-(trans-isoestragol-3′-yl)-2′-deoxyguanosine (E-3′-N2-dG) DNA adducts derived from the alkenylbenzene estragole upon repeated dose exposure was investigated since the repair of this adduct was previously shown to be inefficient. To this end human HepaRG cells were exposed to repeating cycles of 2 h exposure to 50 μM estragole followed by 22 h repair to mimic daily exposure. The E-3′-N2-dG
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Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-08 Shugo Suzuki; Samuel M. Cohen; Lora L. Arnold; Karen L. Pennington; Min Gi; Hiroyuki Kato; Taku Naiki; Aya Naiki-Ito; Hideki Wanibuchi; Satoru Takahashi
Tobacco smoking is a major risk factor for human cancers including urinary bladder carcinoma. In a previous study, nicotine enhanced rat urinary bladder carcinogenesis in a two-stage carcinogenesis model. Nicotine also induced cytotoxicity in the bladder urothelium in a short-term study. In the present study, male rats were treated with nicotine (40 ppm) in drinking water co-administered with the NADPH
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Extended regorafenib treatment can be linked with mitochondrial damage leading to cardiotoxicity Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-07 Tugce Boran; Aysenur Gunaydin Akyildiz; Ayse Tarbin Jannuzzi; Buket Alpertunga
Regorafenib (RGF) has a great success in the treatment of colorectal cancer, gastrointestinal stromal tumours and hepatocellular carcinoma by inhibiting angiogenic, stromal and oncogenic kinases. However, RGF can induce life-threatening cardiotoxicity including hypertension and cardiac ischemia/infarction. The molecular mechanism of the adverse effects has not been elucidated. Mitochondrial dysfunction
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A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation Toxicol. Lett. (IF 3.569) Pub Date : 2020-10-15 Jinmao Liao; Zheng Zhang; Qi Yuan; Qiong Liu; Jia Kuang; Yuan Fang; Xiaoxuan Hu
Hepatic fibrosis is the wound healing response upon the liver tissue damage caused by multiple stimuli. Targeting activated hepatic stellate cells (HSCs), the major extracellular matrix (ECM)-producing cells within the damaged liver, has been regarded as one of the main treatments for hepatic fibrosis. In the present study, we performed preliminary bioinformatics analysis attempting to identify possible
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Downregulation of microRNA-199a-5p alleviated lidocaine-induced sensory dysfunction and spinal cord myelin lesions in a rat model Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-06 Zhong Zhang; Jian Wang; Zongbin Song; Yunjiao Wang; Zhigang Cheng; Qulian Guo; E. Wang; Yanping Jian; Lei Wu
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Sevoflurane increases intracellular calcium to induce mitochondrial injury and neuroapoptosis Toxicol. Lett. (IF 3.569) Pub Date : 2020-11-07 Xiaoqiu Zhu; Yiyi Yao; Mingyan Guo; Jin Li; Pengfeng Yang; Hui Xu; Daowei Lin