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Reactive Skin Decontamination Lotion (RSDL) safety with clinical antiseptics and hemostatic agents Toxicol. Lett. (IF 3.5) Pub Date : 2024-03-13 Jessica Franken, John Mikler
Reactive skin decontamination lotion (RSDL) is a Health Canada approved product used by the Canadian Armed Forces for removal and inactivation of toxic chemicals on skin. Although it is considered very safe when used as directed, questions have been raised regarding whether topical RSDL in the medical setting will react exothermically with antiseptic compounds on the casualty’s epidermis that could
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Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis Toxicol. Lett. (IF 3.5) Pub Date : 2024-03-07 Li Luo, Jiajie Ni, Jiahui Zhang, Jinxian Lin, Sixin Chen, Feihai Shen, Zhiying Huang
Toosendanin (TSN) is the main active component in the traditional herb Siebold & Zucc, which exhibits promising potential for development due to its diverse pharmacological properties. However, the hepatotoxicity associated with TSN needs further investigation. Previous research has implicated autophagy dysregulation in TSN-induced hepatotoxicity, yet the underlying mechanisms remain elusive. In this
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Advancing Ocular Safety Research: A Comprehensive Examination of Benzocaine Acute Exposure without Animal Testing Toxicol. Lett. (IF 3.5) Pub Date : 2024-03-06 Lenze M., Benedetti M.D., Roco J., Ramírez P.G., Blanco R., Yaceszen S., Corrales C., Wikinski S., Gutiérrez M.L.
Benzocaine is a widely employed local anaesthetic; however, there is a notable dearth of preclinical and clinical evidence regarding its safety in ophthalmological products. To address this, a comprehensive strategy incorporating and methodologies was proposed for assessing benzocaine's ocular toxicity without animal testing. To collect the evidence, the QSAR Toolbox (v4.5) was used. A single exposure
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DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways Toxicol. Lett. (IF 3.5) Pub Date : 2024-03-06 Ke Li, Yuzhan Zhang, Weihao Zhao, Rongrong Wang, Yan Li, Linting Wei, Li Wang, Xianghui Chen, Zhao Chen, Pengfei Liu, Na Nie, Xuefei Tian, Rongguo Fu
The pathogenesis of glomerular diseases is strongly influenced by abnormal extracellular matrix (ECM) deposition in mesangial cells. Dipeptidyl peptidase IV (DPPIV) enzyme family contains DPP8 and DPP9, which are involved in multiple diseases. However, the pathogenic roles of DPP8 and DPP9 in mesangial cells ECM deposition remain unclear. In this study, we observed that DPP8 and DPP9 were significantly
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2,3,7,8-Tetrachlorodibenzo-p-dioxin and kynurenine induce Parkin expression in neuroblastoma cells through different signaling pathways mediated by the aryl hydrocarbon receptor Toxicol. Lett. (IF 3.5) Pub Date : 2024-03-02 Fátima E. Murillo-González, Rosario García-Aguilar, Jorge Limón-Pacheco, María Asunción Cabañas-Cortés, Guillermo Elizondo
Parkin regulates protein degradation and mitophagy in dopaminergic neurons. Deficiencies in Parkin expression or function lead to cellular stress, cell degeneration, and the death of dopaminergic neurons, which promotes Parkinson's disease. In contrast, Parkin overexpression promotes neuronal survival. Therefore, the mechanisms of Parkin upregulation are crucial to understand. We describe here the
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A chirality-sensitive approach to predict chemical transfer across the human placental barrier Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-28 Anish Gomatam, Evans Coutinho
The placenta is a membrane that separates the fetus from the maternal circulation, and in addition to protecting the fetus, plays a key role in fetal growth and development. With increasing drug use in pregnancy, it is imperative that reliable models of estimating placental permeability and safety be established. In vitro methods and animal models such as rodent placenta are limited in application
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Mitochondrial uptake of aristolactam I plays a critical role in its toxicity Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-28 Yan Zhou, Ruirui Cui, Mingkang Zhang, Fabing Tang, Xiaohua Ma, Xin’an Wu
Aristolochic acid I (AAI), a component of aristolochic acids, can be converted to the toxic metabolite Aristolactam I (ALI) which forms aristolactam-nitrenium with delocalized positive charges. It is widely accepted that delocalized lipophilic cations can accumulate in mitochondria due to the highly negatively charged microenvironment of the mitochondrial matrix, but the uptake of ALI by mitochondria
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Non-invasive methods of monitoring Fe3O4 magnetic nanoparticle toxicity in human liver HepaRG cells using impedance biosensing and Coherent anti-Stokes Raman spectroscopic (CARS) microscopy Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-28 Joel Kuhn, Alison McDonald, Cyril Mongoin, Graham Anderson, Guillemette Lafeuillade, Stephen Mitchell, Alistair P.D. Elfick, Pierre O. Bagnaninchi, Humphrey H.P. Yiu, Leonard J. Nelson
Functionalized nanoparticles have been developed for use in nanomedicines for treating life threatening diseases including various cancers. To ensure safe use of these new nanoscale reagents, various assays for biocompatibility or cytotoxicity using cell lines often serve as preliminary assessments prior to animal testing. However, many of these assays were designed for soluble, colourless materials
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Development and characterization of an automated behavioral assessment platform for the Göttingen minipig Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-28 Jeffrey L. Langston, Todd M. Myers
The Göttingen minipig is fast becoming the standard for assessing dermal chemical hazards because, like most swine, its skin is predictive of human skin response and because this strain’s smaller size makes laboratory manipulations and husbandry easier. Unfortunately, standard behavioral tests and apparatus have not been developed for behavioral assessments of this swine strain. Indeed, computer-controlled
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Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-27 Aneela Gulnaz, Kyeong-Ryoon Lee, Min-Ji Kang, Ji-Eun Chang, Yoon-Jee Chae
Drug transporters are among the factors that determine the pharmacokinetic profiles after drug administration. In this study, we investigated the roles of drug transporters involved in transport of SN-38, which is an active metabolite of irinotecan, in the intestine under inflammatory conditions and determined their functional consequences. The expression alterations of breast cancer resistance protein
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Dimethylmonothioarsinic acid (DMMTAV) differentially modulates the expression of AHR-regulated cytochrome P450 1A enzymes in vivo and in vitro Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-24 Sara R. El-Mahrouk, Mahmoud A. El-Ghiaty, Mohammed A. Alqahtani, Ayman O.S. El-Kadi
Dimethylmonothioarsinic acid (DMMTA), a pentavalent thio-arsenic derivative, has been found in bodily fluids and tissues including urine, liver, kidney homogenates, plasma, and red blood cells. Although DMMTA is a minor metabolite in humans and animals, its substantial toxicity raises concerns about potential carcinogenic effects. This toxicity could be attributed to arsenicals' ability to regulate
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hsa_circ_0008500 regulates Benzo(a)pyrene-loaded gypsum-induced inflammation and apoptosis in human bronchial epithelial cells via activation of Ahr/C-myc pathways Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-24 Yujun Wang, Juan Song, Jiarui He, Xu Zhang, Zhenzhen Lv, Faqin Dong, Jianjun Deng
Polycyclic aromatic hydrocarbons (PAHs) are major organic pollutants attached to fine particulate matter in the atmosphere. They induce lung inflammation, asthma, and other lung diseases. Exploring the toxic mechanism of PAHs on lung epithelial cells may provide a theoretical basis for the prevention and treatment of respiratory diseases induced by PAHs. In our study, 16 human bronchial epithelial
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Combined in vitro and in silico mechanistic approach to explore the potential of Alternaria mycotoxins alternariol and altertoxin II to hamper γH2AX formation in DNA damage signaling pathways Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-23 Francesco Crudo, Luca Dellafiora, Chenyifan Hong, Lena Burger, Maximilian Jobst, Giorgia Del Favero, Doris Marko
Risk assessment of food and environmental contaminants is faced by substantial data gaps and novel strategies are needed to support science-based regulatory actions. The mycotoxins alternariol (AOH) and altertoxin II (ATXII) have garnered attention for their possible genotoxic effects. Nevertheless, data currently available are rather scattered, hindering a comprehensive hazard characterization. This
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Particle aerosol generation and potential altering in airflow used for acute/repeated inhalation toxicity testing Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-22 Franz Lohse, Benno Wessely, Michael Stintz, Juergen Nolde, Otto Creutzenberg, Gustav Bruer
Reproducible aerosol generation in combination with stable aerosol properties are essential prerequisites for compliant performance of acute or repeated inhalation toxicity tests of particulate materials according to OECD TG 403, 436, 412, or 413. A frequent problem of powder aerosol generation is the formation of coarse agglomerates with low shear resistance, which are beyond the tolerable size range
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Can mothers consume caffeine? The issue of early life exposure and metabolic changes in offspring Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-20 Luana L. Souza, Egberto G. Moura, Patricia C. Lisboa
Caffeine is a substance with central and metabolic effects. Although it is recommended that its use be limited during pregnancy, many women continue to consume caffeine. Direct and indirect actions of caffeine in fetuses and newborns promote adaptive changes, according to the Developmental Origins of Health and Diseases (DOHaD) concept. In fact, epidemiological and experimental evidence reveals the
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Association between brominated flame retardants and risk of endocrine-related cancer: A systematic review and meta-analysis Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-20 Chengchen Shen, Kui Zhang, Jingyi Shi, Jingxuan Yang, Yu Wang, Zhuo Li, Hao Dai, Wenxing Yang
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Screening for New Ligands of the MB327-PAM-1 Binding Site of the Nicotinic Acetylcholine Receptor Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-20 Sonja Sichler, Georg Höfner, Valentin Nitsche, Karin V. Niessen, Thomas Seeger, Franz Worek, Franz F. Paintner, Klaus T. Wanner
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Quantitative modeling of in vitro data using an adverse outcome pathway for the risk assessment of decreased lung function in humans Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-11 Alain Sewer, Marja Talikka, Florian Calvino-Martin, Karsta Luettich, Anita Iskandar
In the absence of epidemiological data, there is a need to develop computational models that convert findings to human disease risk predictions following toxicant exposure. In such efforts, data can be evaluated in the context of adverse outcome pathways (AOPs) that organize mechanistic knowledge based on empirical evidence into a sequence of molecular-, cellular-, tissue-, and organ-level key events
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Toxicokinetic analysis of the highly toxic nerve agent VX in commercially available multi-organ-chips – Ways to overcome compound absorption Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-03 Niko Amend, Marianne Koller, Christian Schmitt, Franz Worek
Organ-on-a-chip technology is considered a next-generation platform in pharmacology and toxicology. Nevertheless, this novel technology still faces several challenges concerning the respective materials which are used for these microfluidic devices. Currently available organ-chips are most often based on polydimethylsiloxane (PDMS). However, this material has strong limitations regarding compound binding
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells Toxicol. Lett. (IF 3.5) Pub Date : 2024-02-02 Xilin Li, Yuan Le, Yuxi Li, Si Chen, Lei Guo, Xin Fu, Mugimane G. Manjanatha, Nan Mei
Hydroxychloroquine (HCQ), a derivative of chloroquine (CQ), is an antimalarial and antirheumatic drug. Since there is limited data available on the genotoxicity of HCQ, in the current study, we used a battery of in vitro assays to systematically examine the genotoxicity of HCQ in human lymphoblastoid TK6 cells. We first showed that HCQ is not mutagenic in TK6 cells up to 80 μM with or without exogenous
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Lead inhibits microglial cell migration via suppression of store-operated calcium entry Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-26 Wei Tang, Jiawen Peng, Lixuan Chen, Changhui Yu, Yuhao Wang, Fei Zou, Gang Zheng, Xiaojing Meng
Lead (Pb) is a non-biodegradable environmental pollutant that can lead to neurotoxicity by inducing neuroinflammation. Microglial activation plays a key role in neuroinflammation, and microglial migration is one of its main features. However, whether Pb affects microglial migration has not yet been elucidated. Herein, the effect of Pb on microglial migration was investigated using BV-2 microglial cells
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Involvement of pro-inflammatory mediators and cell cycle disruption in neuronal cells induced by gliotoxin and ochratoxin A after individual and combined exposure Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-18 Raquel Penalva-Olcina, Cristina Juan, Mónica Fernández-Franzón, Ana Juan-García
Mycotoxins such as gliotoxin (GTX) and ochratoxin A (OTA) are secondary metabolites of and found in food and feed. Both mycotoxins have shown to exert a detrimental effect on neuronal activity. The following study was carried out to elucidate the mechanisms by which GTX and OTA exert their toxicity. Non-differentiated SH-SY5Y neuronal-like cells were treated with GTX, OTA and their combinations to
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Herpesvirus activated NF-κB-mediated antigen processing and presentation to aggravate trichloroethylene-induced hypersensitivity dermatitis Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-17 Mengnan Yi, Yong Niu, Shuai Liu, Yuanyuan Chen, Bo Jiao, Yican Wang, Haijun Du, Guoyong Mei, Huawei Duan, Jun Han, Yufei Dai
Trichloroethylene-induced hypersensitivity dermatitis (TIHD) is a delayed hypersensitivity response that is affected by genetic and environmental factors. Occupational exposure to trichloroethylene (TCE) enhances antigen presentation, leading to hypersensitivity in workers with the HLA-B* 13:01 allele. Several studies have observed the activation of herpesviruses, such as EpsteinBarr virus (EBV), in
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Dissolution behavior of stone wool fibers in synthetic lung fluids: Impact of iron oxidation state changes induced by heat treatment for binder removal Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-15 D.V. Okhrimenko, K.H. Rasmussen, J.A. Bøtner, M. Ceccato, M. Foss, M. Solvang
Stone wool fiber materials are commonly used for thermal and acoustic insulation, horticulture and filler purposes. Biosolubility of the stone wool fiber (SWF) materials accessed through acellular dissolution tests can potentially be used in future as an indicator of fiber biopersistence . To correlate acellular studies with and epidemiological investigations, not only a robust dissolution procedure
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Toxicokinetic study of scandium oxide in rats Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-11 Aristine Nnomo Assene, Denis Dieme, Malek Jomaa, Jonathan Côté, Michèle Bouchard
Canada has recently invested in the large-scale exploitation of scandium oxide. However, there are no studies available to date to understand its toxicokinetics in the animal or human body, which is necessary to assess exposure and health risks. The aim of this research was to investigate the toxicokinetics of absorbed scandium oxide (Sc2O3) using the rat as an experimental model. Male Sprague-Dawley
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Mechanisms of hepatocellular toxicity associated with the components of St. John’s Wort extract hypericin and hyperforin in HepG2 and HepaRG cells Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-14 Vanessa Fabienne Abegg, Miljenko Valentin Panajatovic, Riccardo Vincenzo Mancuso, Julien Arthur Allard, Urs Duthaler, Alex Odermatt, Stephan Krähenbühl, Jamal Bouitbir
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The short-term toxicity and metabolome of dicyclopentadiene Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-12 Bennard van Ravenzwaay, Neslihan Aygun Kocabas, Frank Faulhammer, Burkhard Flick, Varun Giri, Saskia Sperber, Michael G. Penman, Larry G. Higgins, Hennicke Kamp, Martijn Rooseboom
Dicyclopentadiene (DCPD) was investigated in a 14-day oral rat toxicity study based on the OECD 407 guideline in combination with plasma metabolomics. Wistar rats received the compound daily via gavage at dose levels of 0, 50 and 150 mg/kg bw. The high dose induced transient clinical signs of toxicity and in males only reduced body weight gain. High dose liver changes were characterized by altered
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MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-10 Valentin Nitsche, Georg Höfner, Jesko Kaiser, Christoph G.W. Gertzen, Thomas Seeger, Karin V. Niessen, Dirk Steinritz, Franz Worek, Holger Gohlke, Franz F. Paintner, Klaus T. Wanner
Intoxications with organophosphorus compounds (OPCs) based chemical warfare agents and insecticides may result in a detrimental overstimulation of muscarinic and nicotinic acetylcholine receptors evolving into a cholinergic crisis leading to death due to respiratory failure. In the case of the nicotinic acetylcholine receptor (nAChR), overstimulation leads to a desensitization of the receptor, which
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Dose- and stage-dependent toxic effects of prenatal prednisone exposure on fetal articular cartilage development Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-10 Junmiao Xu, Qi Zhang, Tao Jiang, Liang Liu, Hanwen Gu, Yang Tan, Hui Wang
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Cadmium promotes the binding and centrosomal translocation of CCDC85C and PLK4 via ROS-GCLM pathway to trigger centrosome amplification in colon cancer cells Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-06 Ya Wen Han, Si Xian Xu, Jun Zhang, Yuan Fei Li, Peng Xu, Shao Chin Lee, Ji Zhong Zhao
Cadmium (Cd) is a prevalent heavy metal contaminant that can cause centrosome amplification (CA) and cancer. Since CA can initiate tumorigenesis, it is plausible that cadmium initiates tumorigenesis via CA. The present study investigated the signaling pathways underlying CA by Cd. Our findings confirmed that sub-toxic concentrations of Cd could induce CA in the HCT116 colon cancer cells, and revealed
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miR-520f-3p blocks MNNG-induced gastric precancerous lesions via the KLF7/NFκB pathway Toxicol. Lett. (IF 3.5) Pub Date : 2024-01-04 Wei Jiang, Wei Lu, Jun Liu, Haixia Ren, Xuequn Zhao, Wenjie Yang
Studying the regulatory mechanism of gastric disease progression to gastric cancer (GC) is essential. miR-520f expression is down-regulated in GC and inhibits the proliferation of gastric cancer cells, suggesting that it is associated with the development of GC, but whether it plays a role in the gastric precancerous lesion (GPL) is unclear. This study aimed to investigate the effect of miR-520f-3p
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Regenerative and progressing lesions in lungs and lung-associated lymph nodes from fourteen 90-day inhalation studies with chemically different particulate materials Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-29 Klaus Weber, Gustav Bruer, Nils Krueger, Tobias B. Schuster, Otto Creutzenberg, Dirk Schaudien
Rat lungs and lung-associated lymph nodes from 14 inhalation studies with chemically different particulate materials were histopathologically re-evaluated, and the bronchoalveolar lavage fluid (BALF) data and lung burden analyses were compared. All investigated substances caused similar lesions. For most substances, 1 mg/m3 of respirable particulate matter was established as the borderline for adverse
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AChE reactivation in Precision-cut lung slices following organophosphorus compound poisoning Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-29 Fee Gölitz, Julia Herbert, Franz Worek, Timo Wille
Precision-cut lung slices (PCLS) are a suitable model for analyzing the acetylcholinesterase (AChE) activity and subsequent effects after exposure to organophosphorus (OP) compounds. In this study, the AChE activity was determined in intact PCLS for the first time. Since the current standard therapy for OP poisoning (atropine + oxime + benzodiazepine) lacks efficiency, reliable models to study novel
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Perfluorooctanoic acid (PFOA) exposure induces renal filtration and reabsorption disorders via down-regulation of aquaporins Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-18 Li Wang, Weiqiang Sun, Xinzhuang Ma, Nathan Griffin, Hui Liu
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Role of covalent modification by hepatic aldehydes in dictamnine-induced liver injury Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-19 Qi Luo, Yang Shen, Guohong Zhai, Lin Chen, Furong Ou, Luxi Yi, Danli Yang, Hong Pan, Fuguo Shi
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In vitro permeation of nicotine and tobacco specific nitrosamines from smokeless tobacco product extracts in a 3D buccal tissue model Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-22 Brian M. Keyser, Hannah Flockton, Randy A. Weidman, Rebecca Payne, Jannell Rowe, Kristen G. Jordan
Tobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful constituents (HPHCs), the oral permeation of HPHCs in oral tobacco products is not completely understood. To improve the understanding, three different
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Acrolein suppresses anticancer drug-induced toxicity mediated by activating claudin-1 and Nrf2 axis in a spheroid model of human lung squamous cell carcinoma cells Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-22 Hiroaki Eguchi, Yaqing Yu, Toshiyuki Matsunaga, Yuta Yoshino, Akira Ikari
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An in-silico porcine model of phosgene-induced lung injury predicts clinically relevant benefits from application of continuous positive airway pressure up to 8 h post exposure Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-12 Sonal Mistry, Timothy E. Scott, Bronwen Jugg, Rosi Perrott, Sina Saffaran, Declan G. Bates
We present the first computational model of the pathophysiological consequences of phosgene-induced lung injury in porcine subjects. Data from experiments previously performed in several cohorts of large healthy juvenile female pigs (111 data points from 37 subjects), including individual arterial blood gas readings, respiratory rate and heart rate, were used to develop the computational model. Close
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Multi-Fusarium mycotoxin exposure activates Nrf2 and Ahr pathway in the liver of laying hens Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-12 Benjamin Kövesi, Szabina Kulcsár, Zsolt Ancsin, Márta Erdélyi, Erika Zándoki, Patrik Gömbös, Krisztián Balogh, Miklós Mézes
This study investigates gene expression changes in laying hens exposed to trichothecene mycotoxins, known to induce oxidative stress and affect xenobiotic transformation and antioxidants. A 3-day feeding trial tested low and high doses of T-2/HT-2 toxin, DON/3-AcDON/15-AcDON, and FB1 in hen feed. Results showed increased expression of AHR, AHRR, HSP90, and CYP1A2 genes on days 2 and 3, suggesting a
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The association between neuropsychiatric effects of substance use and occurrence of endoplasmic reticulum and unfolded protein response: A systematic review Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-14 Bin Yang, Ruiling Zhang, Mohammad Farris Iman Leong Bin Abdullah
Introduction This systematic review aimed to assess the association between neuropsychiatric effects of substance use and occurrence of ER stress and unfolded protein response (UPR) through comprehensive electronic search of existing literature and review of their findings. Methods A comprehensive electronic literature search was carried out on research articles published between 1950 to July 2023
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The mechanism of blood coagulation induced by sodium dehydroacetate via the regulation of the mTOR/ERK pathway in rats Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-15 Meng Zhang, Qingqi Zhang, Weiya Zhao, Xin Chen, Yumei Zhang
Sodium dehydroacetate (DHA-S), a potent antifungal and antibacterial agent, is widely used in food, feed and cosmetics. However, recent studies have shown that DHA-S could pose a risk for human and animal health. We had previously reported that DHA-S could cause coagulation disorders in rats and chicken. In the present study, we further confirmed that DHA-S induced blood coagulation via VKORC1 and
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Gentamicin administration leads to synaptic dysfunction in inner hair cells Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-13 Gen Li, Yunge Gao, Hao Wu, Ting Zhao
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Cyanobacterial anatoxin-a does not induce in vitro developmental neurotoxicity, but changes gene expression patterns in co-exposure with all-trans retinoic acid Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-07 Barbara Kubickova, Sarka Martinkova, Dasa Bohaciakova, Klara Hilscherova
Cyanobacterial blooms are increasing in frequency and intensity globally, and impacting recreational waters as well as waters used for drinking water provisioning. They are sources of bioactive metabolites including retinoids and the neurotoxin anatoxin-a. Here, we investigated the effects of anatoxin-a on a differentiating in vitro human neural stem cell model previously characterised with retinoic
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Lipid characteristics of lung tissue in silicosis rat model were studied based on lipid metabolomics Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-05 Hailan He, Rong Qi, Jie Cui, Mingming Liu, Bo Guan, Yufan Zhou, Yingshu Zhang, Xiaohui Hao, Hongli Wang, Heliang Liu
Silicosis is a common occupational disease caused by the long-term inhalation of large amounts of silica dust. Lipid metabolism plays an important role in the progression of silicosis, but its contributing mechanism remains unclear. The aim of this study was to investigate the differential lipid metabolites and active metabolic pathways in silicosis rat lung tissue. We first constructed a silicosis
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Pb induces the release of CXCL10 and CCL2 chemokines via mtROS/NF-κB activation in BV-2 cells Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-05 Chenghao Jiang, Xintong Li, Cui Xiang, Fang Ye
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Phospholipid chlorohydrins as chlorine exposure biomarkers in a large animal model Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-03 Petrus Hemström, Bronwen Jugg, Rachel Watkins, Sofia Jonasson, Linda Elfsmark, Stephen Rutter, Crister Åstot, Pernilla Lindén
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Efficacy of the oxime HI-6 dimethanesulphonate in the treatment of guinea-pigs exposed to the nerve agents GB and GD Toxicol. Lett. (IF 3.5) Pub Date : 2023-12-02 Helen Rice, Sarah J. Whitfield, Sarah J. Fairhall, Iain R. Scott, Glyn B. Steventon, John E.H. Tattersall
The bispyridinium oxime HI-6 DMS is in development as an improved therapy for the treatment of patients exposed to organophosphorus nerve agents. The aim of the work described in this paper was to provide non-clinical data to support regulatory approval of HI-6 DMS, by demonstrating efficacy against an oxime-sensitive agent, GB and an oxime-resistant agent, GD. We investigated the dose-dependent protection
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BDE-47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPARα-induced abnormal fatty acid oxidation in BALB/c mice Toxicol. Lett. (IF 3.5) Pub Date : 2023-11-29 Beibei Xia, Rongfei Yu, Junxiong Liu, Dongmeng Liu, Shasha Li, Liu Yang, Nan Liu, Bosen Liang, Jiajing Zeng, Jinhua Wei, Guimiao Lin
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Regulation of long non-coding RNA expression by aryl hydrocarbon receptor activation Toxicol. Lett. (IF 3.5) Pub Date : 2023-11-28 Aeshah Alluli, Gregory Fonseca, Jason Matthews, David H. Eidelman, Carolyn J. Baglole
The aryl hydrocarbon receptor (AhR) is a cytosolic transcription factor that can be activated by endogenous or xenobiotic ligands. Upon activation, the AhR translocates to the nucleus, dimerizes with the AhR nuclear translator (ARNT), and binds to specific DNA sequences called xenobiotic response elements (XRE) to promote target gene transcription, including cytochrome P450 (e.g., CYP1A1) expression
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The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: Insight on the molecular mechanisms in HepG2/THP-1 co-culture model Toxicol. Lett. (IF 3.5) Pub Date : 2023-11-21 Tugce Boran, Ozge Sultan Zengin, Zehra Seker, Aysenur Gunaydin Akyildiz, Ezgi Oztas, Gül Özhan
Drug-induced liver injury (DILI) is one of the widespread causes of liver injury and immune system plays important role. Abemaciclib (ABE) is a cyclin-dependent kinase inhibitor used as monotherapy or combination therapy in the treatment of breast cancer. Like other kinase inhibitors, the underlying mechanisms of ABE-induced hepatotoxicity are not completely known yet. In the current study, hepatotoxicity
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Corrigendum to “Cytoprotective effect of deferiprone against aluminum chloride-induced oxidative stress and apoptosis in lymphocytes” [Toxicol. Lett. 285 (2018) 132–138] Toxicol. Lett. (IF 3.5) Pub Date : 2023-11-10 Cuicui Zhuang, Yue She, Haiyang Zhang, Miao Song, Yanfei Han, Yanfei Li, Yanzhu Zhu
Abstract not available
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Formaldehyde promotes tumor-associated macrophage polarizations and functions through induction of HIF-1α-mediated glycolysis Toxicol. Lett. (IF 3.5) Pub Date : 2023-11-07 Qi Shu, Huijuan Ma, Tingqian Wang, Peiyao Wang, Huan Xu
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TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP Toxicol. Lett. (IF 3.5) Pub Date : 2023-11-07 Xue Fan, Yangping Zhu, Shuang Peng, Yingying Miao, Qian Lu, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
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Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats Toxicol. Lett. (IF 3.5) Pub Date : 2023-11-04 Yasunori Takahashi, Ryota Ojiro, Risako Yamashita, Saori Shimizu, Natsuno Maeda, Xinyu Zou, Qian Tang, Shunsuke Ozawa, Gye-Hyeong Woo, Toshinori Yoshida, Makoto Shibutani
We previously performed comprehensive analyses of genes hypermethylated promoter regions and downregulated transcripts in the hippocampal dentate gyrus (DG) of rats upon weaning at postnatal day (PND) 21 after developmental exposure to 6-propyl-2-thiouracil (PTU), valproic acid, and glycidol (GLY), all of which are known to show irreversible effects on hippocampal neurogenesis in adulthood on PND 77
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Use of the TD50 99 % CI for single dose rodent carcinogenicity studies Toxicol. Lett. (IF 3.5) Pub Date : 2023-11-03 Robert Thomas, Antonio Anax F. Oliveira, David J. Ponting, Andrew Thresher
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Usage of model combination in computational toxicology Toxicol. Lett. (IF 3.5) Pub Date : 2023-10-27 Pablo Rodríguez-Belenguer, Eric March-Vila, Manuel Pastor, Victor Mangas-Sanjuan, Emilio Soria-Olivas
New Approach Methodologies (NAMs) have ushered in a new era in the field of toxicology, aiming to replace animal testing. However, despite these advancements, they are not exempt from the inherent complexities associated with the study's endpoint. In this review, we have identified three major groups of complexities: mechanistic, chemical space, and methodological. The mechanistic complexity arises
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Differentiated and non-differentiated HepaRG™ cells: A possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens Toxicol. Lett. (IF 3.5) Pub Date : 2023-10-27 Michael Gutmann, Emily Stimpfl, Gregor Langmann, Helga Koudelka, Birgit Mir-Karner, Bettina Grasl-Kraupp
Many xenobiotics are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action (MoA) and health risks for humans are unclear and no in-vitro tests are available to predict NGC. Human HepaRG™ cells in the differentiated (d-HepaRG) and non-differentiated state (nd-HepaRG) were studied as new approach methodology (NAM) for NGC. Cell-biological assays were performed with d-/nd-HepaRG and human
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Corrigendum to “SOD2 promotes the expression of ABCC2 through lncRNA CLCA3p and improves the detoxification capability of liver cells” [Toxicol. Lett. 327 (2020) 9–18] Toxicol. Lett. (IF 3.5) Pub Date : 2023-10-23 X. Wang, M. Li, L. Peng, N. Tang
Abstract not available