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Short-term dietary magnesium deficiency downregulates the expression of bone formation-related genes in rats Magnes. Res. (IF 3.2) Pub Date : 2023-09-01 Shinichi Katsumata, Hiroshi Matsuzaki
Dietary magnesium deficiency increases osteoclastic bone resorption and decreases osteoblastic bone formation. Increased bone resorption due to dietary magnesium deficiency can be explained by increased expression of the receptor activator of nuclear factor kB ligand. However, the detailed mechanisms underlying decreased bone formation remain unclear. Thus, in the present study, to determine the mechanism
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Hypomagnesemia and 25-hydroxyvitamin D deficiency in patients with long COVID Magnes. Res. (IF 3.2) Pub Date : 2023-09-01 Fernando Guerrero-Romero, Claudia I. Gamboa-Gómez, Martha Rodríguez-Morán, Maya Orrante, Estefany Rosales-Galindo, Itzel Cisneros-Ramírez, Mariana Arce-Quiñones, Karen Orona-Díaz, Luis E. Simental-Mendia, Gerardo Martínez-Aguilar
The number of clinical manifestations of long COVID were significantly higher in the risk compared to the control group. Fatigue, memory loss, attention disorders, joint pain, anxiety, sleep disorders, myalgia, and depression, all of which are related to hypomagnesemia and/or 25-hydroxyvitamin D deficiency, were among the 10 most frequent manifestations in the risk group. The adjusted odds ratio for
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Association between serum magnesium trajectory and in-hospital mortality in hospitalized patients with sepsis: an analysis of the MIMIC-IV database Magnes. Res. (IF 3.2) Pub Date : 2023-09-01 Xuan Xia, Huan Guo, Hongyu Sun
Adult sepsis patients who had complete data on serum magnesium at ICU admission (at 0, 12, 24, 36 and 48 hours after ICU admission) based the 2012-2019 Medical Information Mart for Intensive Care IV (MIMIC-IV) database were included in this retrospective cohort study. Serum magnesium trajectories were identified using K-means cluster analysis. The multivariable Cox proportional-hazards model was used
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Administration of magnesium sulphate does not prevent post-reperfusion syndrome but is necessary during living donor liver transplantation. Magnes. Res. (IF 3.2) Pub Date : 2023-06-01 Dheapak Vijayakumar,Lalita Gouri Mitra,Shivali Panwar,Amal Francis Sam
Severe hemodynamic instability is observed during portal vein de-clamping in the form of post-reperfusion syndrome in liver transplantation. The protective effect of magnesium on inflammation and ischemia-reperfusion injuries of various organs is evident, but its role in the prevention of post-reperfusion syndrome in liver transplantation is not clear. We investigated the effect of magnesium sulphate
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Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis. Magnes. Res. (IF 3.2) Pub Date : 2023-06-01 Ebru Yilmaz,Sena Ünver
The maintenance of various physiological cellular processes requires mineral magnesium (Mg). The purpose of the study was to determine a possible association between Mg level and vitamin D levels, bone mineral density (BMD), chronic diseases, and radiographic stage in individuals with knee osteoarthritis (OA). The study included 98 individuals (62 female and 36 male) who had been diagnosed with at
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A case-control study showing low creatinine clearance and high magnesium intake as risk factors for hypermagnesemia in older individuals Magnes. Res. (IF 3.2) Pub Date : 2023-06-01 Hidetoshi Ishii, Risa Sawada, Megumi Shiomi, Kiyoshi Shibuya
According to epidemiological studies, constipation has a negative effect on life expectancy, necessitating appropriate treatment. According to the Pharmaceuticals and Medical Devices Agency (PMDA), patients who have been taking magnesium oxide (MgO) for constipation over a prolonged period, especially those with impaired renal function and older individuals, are at high risk of hypermagnesemia. Therefore
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Effects of magnesium sulphate on neostigmine-induced recovery from moderate neuromuscular blockade with rocuronium: a randomized controlled trial Magnes. Res. (IF 3.2) Pub Date : 2023-06-01 Jiwon Han, Hee-Yeon Park, Hyun-Jung Shin, Seung Hyun Chung, Sang-Hwan Do
Neostigmine-induced recovery time was comparable between Group M and Group C (10.6 ± 4.3 vs. 9.1 ± 5.0 min, respectively, p = 0.22). The rocuronium onset time was shorter in Group M, and the spontaneous recovery period was longer in Group M. The amount of additional rocuronium administered was 27% lower in Group M, but this difference was not significant.
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The relationship between venous insufficiency and serum magnesium level Magnes. Res. (IF 3.2) Pub Date : 2022-10-01 Serhat Caliskan, Mehmet Atay, Seyda Gunay-Polatkan, Deniz Sigirli
A total of 600 participants were included. There was no significant difference between the groups in terms of age and gender. In total, 187 (47.46%) patients with chronic venous insufficiency and 105 (50.97%) of the control group were male (p=0.414). The median age of the patients with chronic venous insufficiency was 48 (min-max: 41-49), and the median age of the control group was 49.00 (min-max:
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Magnesium supplementation reduces interleukin-6 levels in metabolic syndrome. Magnes. Res. (IF 3.2) Pub Date : 2023-03-01 Sophia Kisters,Klaus Kisters,Tanja Werner,Timm Westhoff,Hans-Georg Predel,Hannes Reuter
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Magnesium suppresses in vivo oxidative stress and ex vivo DNA damage induced by protracted ACTH treatment in rats Magnes. Res. (IF 3.2) Pub Date : 2023-03-01 Vedrana Đurić, Jelena Petrović, Dušanka Stanić, Ana Ivanović, Jelena Kotur-Stevuljević, Vesna Pešić
Oxidative stress, arising from disrupted balance between reactive oxygen/nitrogen species (ROS/RNS) and antioxidant defences, has been implicated in the pathogenesis of stress-related disorders. There is a growing body of evidence that supports the relationship between the activity of the hypothalamic-pituitary-adrenal (HPA) stress system, oxidative stress and magnesium (Mg) homeostasis. The present
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Evaluation of standard versus prolonged magnesium infusion rates in hospitalized patients: a retrospective cohort study Magnes. Res. (IF 3.2) Pub Date : 2023-03-01 Halah Yaldo, Renee Paxton, Christopher Giuliano
Background: Hypomagnesemia is a common electrolyte abnormality in hospitalized patients. Prolonging the infusion rate of magnesium has been hypothesized to increase retention of magnesium, however, there is limited evidence to support prolonging the rate of infusion. Aim: To compare the absolute change in serum magnesium levels from baseline to levels drawn within 24 hours after the end of infusion
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Glasgow Magnesium Symposium 2022: Wrap up and depart Magnes. Res. (IF 3.2) Pub Date : 2022-10-10 Federica I Wolf,Valentina Trapani,Rhian Touyz
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Correlation between magnesium sulphate exposure in utero and serum calcium and alkaline phosphatase levels in preterm infants Magnes. Res. (IF 3.2) Pub Date : 2022-10-01 Aoki Kuraaki, Matsu-uchi Shoko, Akaba Kazuhiro
Preterm infants in the exposure group were antenatally exposed to MgSO4 for a median (IQR) period of 14 (5-34) days and a dosage of 447 (138-1118) g. Serum calcium levels were lower (8.8 vs 9.4 mg/dL, p<0.001) and ALP levels were higher (312 vs 196 U/L, p<0.001) in the exposure group. Serum calcium levels did not correlate with MgSO4 administration dosage and therapy duration, however, ALP levels correlated
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Magnesemia in COVID-19 ICU patients: the relationship between serum magnesium level and mortality Magnes. Res. (IF 3.2) Pub Date : 2022-07-01 Bilge Banu Taşdemir Mecit, Semiha Orhan
For patients with Mg value of <2 mg/dL, the proportion of males to females was roughly equal, however, the proportion of males was higher in other groups (p = 0.004). Overall, hypertension was the most common comorbid disease in patients, followed by diabetes mellitus in 32.1%. The latter was observed more frequently in Group 1 (<1.8 mg/dL) compared to the other groups (51.3%, p = 0.008). No significant
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Development of a bio-relevant pH gradient dissolution method for a high-dose, weakly acidic drug, its optimization and IVIVC in Wistar rats: a case study of magnesium orotate dihydrate Magnes. Res. (IF 3.2) Pub Date : 2022-07-01 Hitesh Verma, Rajeev Garg
Magnesium orotate dihydrate (MOD) is a weakly acidic drug (pKa 2.83) which belongs to Biopharmaceutical Classification System (BCS) Class I at a dose of 500 mg and to BCS Class II at a dose of 1,000 mg. It is clinically prescribed at a dose of 3,000 mg (in two to three divided doses). The aim of the present study was to develop a bio-relevant pH gradient dissolution method for MOD in order to evaluate
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Is serum magnesium level associated with atrial fibrillation in the mixed medical/surgical intensive care unit setting? Magnes. Res. (IF 3.2) Pub Date : 2022-07-01 Bişar Ergün, Begüm Ergan, Murat Küçük, Mehmet Nuri Yakar, Mehmet Celal Öztürk, Ferhan Demirer Aydemir, Özlem Öner, Volkan Hanci, Bilgin Cömert, Ali Necati Gökmen
The incidence of NOAF was 2.4% (n = 110) between January 2013 and June 2020. At NOAF onset or the matched time point, median serum magnesium levels were lower in the NOAF group than in the control group (0.84 [0.73-0.93] vs. 0.86 [0.79-0.97] mmol/L; p = 0.025). At NOAF onset or the matched time point, 24.5% (n = 27) in the NOAF group and 12.7% (n = 14) in the control group had hypomagnesemia (p = 0
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Hypomagnesemia is associated with increased mortality in the short-term but not the long-term in community-acquired pneumonia patients with type 2 diabetes Magnes. Res. (IF 3.2) Pub Date : 2022-04-01 Xiao-Li Liu, Si-Qiong Wang, Mei-Jing Ji, Xiao-Ming Wang, Jing Sun, Meng-Meng Zhang, Chun-Ming Ma
In total, 480 CAP inpatients with T2DM were enrolled, and 71 patients (14.8%) had hypomagnesemia on admission. After one month and three months of follow-up, the hypomagnesemia group had a higher mortality rate than the normal magnesium group (p<0.05). After six months of follow-up, the mortality rate remained higher in the hypomagnesemia group, however, this was not statistically significant (χ2=2
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Oral magnesium sulphate administration in rats with minimal hepatic encephalopathy: NMR-based metabolic characterization of the brain Magnes. Res. (IF 3.2) Pub Date : 2022-04-01 Xue-Fei Liu, Jin-Jin Lu, Ying Li, Xiu-Ying Yang, Jin-Wei Qiang
A significantly decreased number of entries into the MWM within the range of interest, longer latency and total time during NBW, and higher brain manganese content were found in rats with MHE. After magnesium sulphate treatment, the rats with MHE had better behavioural performance and lower brain manganese content. The 25 and 26 metabolomic signatures were identified in the cortex and striatum of rats
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Plasma and erythocyte magnesium levels: from validation of the method to analysis in volunteers diagnosed to migraine Magnes. Res. (IF 3.2) Pub Date : 2022-04-01 Marcio Tadashi Hoshino, Matheus Gomes Bochio, Juliandra Spagnol Bonache, Larissa Ludwig, Michel Leandro de Campos, Guilherme Luz Emerick
Deficiency of serum magnesium is associated with the incidence of migraine attacks. The present study aimed to evaluate plasma and erythrocyte magnesium levels in a group of patients diagnosed with migraine. Human donors were selected from basic health units (migraine, n = 25) and from a collection and transfusion unit (control, n = 25), both located in the city of Sinop, Brazil. Plasma and erythrocyte
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Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery Magnes. Res. (IF 3.2) Pub Date : 2022-04-01 Sara Saba, Fakhrudin Faizi, Mojtaba Sepandi, Batool Nehrir
After the intervention, the mean level of magnesium in the intervention group was significantly higher (p=0.001). At the end of the study, the mean level of anxiety and depression was significantly lower in the intervention group than the control group (p=0.007), moreover, mean sleep quality improved in the intervention group (8.3 ± 2.1) compared to the control group (10.3 ± 2.0) (p=0.001).
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Incidence of ionized hypomagnesemia in adult patients undergoing noncardiac major surgery: a prospective observational trial Magnes. Res. (IF 3.2) Pub Date : 2022-01-01 Hyun-Jung Shin, Jiwon Han, Subin Yim, Sang-Hwan Do
There was a marked difference between the incidence of preoperative ionized and total hypomagnesemia (28% vs. 19%; p<0.001). The postoperative values of ionized magnesium, ionized calcium, and albumin were significantly lower than the respective preoperative values (p<0.001 for all three variables).
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A potential protective role of magnesium in neuroCOVID Magnes. Res. (IF 3.2) Pub Date : 2022-01-01 Valentina Cenacchi, Jeanette A. Maier, Maria Paola Perini
Several recent studies support a role of dysregulated magnesium homeostasis in COVID-19. In the present narrative review, we focus on the neurological aspects of this disease, collectively known as neuroCOVID, and we propose some mechanisms by which alterations of magnesium may contribute to the involvement of the nervous system in the context of SARS-CoV-2 infection. Further fundamental, translational
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Corrigendum to "biopharmaceutics classification and pharmacokinetics study of magnesium orotate" (Mag Res 2019;32:132-42) Magnes. Res. (IF 3.2) Pub Date : 2022-01-01 Hitesh Verma,Rajeev Garg
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Magnesium sulphate activates the L-arginine/NO/cGMP pathway to induce peripheral antinociception in mice Magnes. Res. (IF 3.2) Pub Date : 2022-01-01 Loyara Rocha Miranda Teixeira, Andrea Castro Perez, Thiago Roberto Lima Romero, Igor Dimitri Gama Duarte
In the present study, we investigated whether magnesium sulphate activates the L-arginine/NO/cGMP pathway and elicits peripheral antinociception. The male Swiss mice paw pressure test was performed with hyperalgesia induced by intraplantar injection of prostaglandin E2. All drugs were administered locally into the right hind paw of animals. Magnesium sulphate (20, 40, 80 and 160 μg/paw) induced an
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Increasing public health awareness of magnesium: one step at a time Magnes. Res. (IF 3.2) Pub Date : 2022-01-01 Rebecca B Costello,Andrea Rosanoff
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Relationship of dietary magnesium intake and serum magnesium with hypertension: a review Magnes. Res. (IF 3.2) Pub Date : 2021-10-01 Nikolina Banjanin, Goran Belojevic
The relationship between magnesium and hypertension has been intensively investigated in the last few decades. Most of the so far reviews were focused on either dietary magnesium or serum magnesium or magnesium supplements. Our goal was to merge these findings with a more comprehensive approach. Internet search was performed in PubMed database without date limits, using the following search terms “dietary
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The association between abnormal serum magnesium levels and prognosis of elderly patients with community-acquired pneumonia Magnes. Res. (IF 3.2) Pub Date : 2021-10-01 Si-Qiong Wang, Dong-Xi Lu, Jian-Dong Zhang, Zhi-Wei Wang, Xiao-Wei Li, Chun-Ming Ma
The percentages of respiratory failure and mechanical ventilation were 18.6% and 10.6 % in the normal group, 29% and 16.5 % in the hypomagnesemia, and 42.9% and 35.7% in the hypermagnesemia groups. The occurrence of shock was 8.5% and 4.5% in the hypomagnesemia group and the normal group. The percentages of the length of stay at ICU were 14.9%, 18.8%, and 57.1% in the hypomagnesemia, normal, and hypermagnesemia
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Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome: a 12-week, placebo-controlled, double-blinded pilot trial Magnes. Res. (IF 3.2) Pub Date : 2021-07-01 Kseniia Afitska, Julia Clavel, Klaus Kisters, Jürgen Vormann, Tanja Werner
Magnesium (Mg) supplementation was shown to improve metabolic syndrome (MetS) parameters in hypomagnesemic patients. The current study evaluated the role of Mg in normomagnesemic individuals with MetS. Patients were randomly assigned to 400 mg Mg as Mg citrate or placebo daily for 12 weeks. Blood pressure (BP), HbA1c, plasma concentrations of glucose, Mg and Ca, blood-ionized Mg, serum concentrations
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Magnesium favors the capacity of vitamin D3 to induce the monocyte differentiation of U937 cells Magnes. Res. (IF 3.2) Pub Date : 2021-07-01 Sandra Parenti, Laura Sandoni, Monica Montanari, Tommaso Zanocco-Marani, Alexandre Anesi, Stefano Iotti, Rossella Manfredini, Chiara Frassineti, Pierpaola Davalli, Alexis Grande
The hematopoietic U937 cells are able to differentiate into monocytes, macrophages, or osteoclasts when stimulated, respectively, with vitamin D3 (VD3), phorbol 12-myristate 13-acetate (PMA) or PMA plus VD3. We have previously demonstrated that magnesium (Mg) strongly potentiates the osteoclastic differentiation of U937 cells. In this study, we investigated whether such an effect may be ascribed to
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Relationship of magnesemia with myocardial damage and mortality in patients with COVID-19 Magnes. Res. (IF 3.2) Pub Date : 2021-07-01 Seyda Gunay, Serhat Caliskan, Deniz Sigirli
A total of 629 patients with COVID-19 were included. Mortality rate was 11.85% (n = 82). There were 61 (74.4%) and 294 male patients (53.7%) in NSG and SG, respectively (p = 0.001). The median age of NSG was 64.5 years (min-max: 37–93) and the median age of SG was 56.0 years (min-max: 22–92) (p < 0.001). Median serum magnesium levels of NSG and SG were 1.94 mg/dL (min-max: 1.04-2.87) and 2.03 mg/dL
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Serum magnesium in patients with severe acute respiratory syndrome coronavirus 2 from Wuhan, China Magnes. Res. (IF 3.2) Pub Date : 2021-07-01 Linyun Zhu, Xingxing Bao, Junjie Bi, Yuhua Lin, Cuiting Shan, Xuanfei Fan, Junmei Bian, Xiongbiao Wang
Eighteen patients had hypomagnesemia during hospitalization. Fourteen patients were in the critical group and six died. In the critical group, serum magnesium (0.72 ± 0.15 mmol/L) was much lower than that in the moderate and severe groups. At the same time, we also found that several indicators are correlated with the level of magnesium. The level of magnesium was positively associated with the lymphocyte
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[The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19]. Magnes. Res. (IF 3.2) Pub Date : 2021-05-01 Federica I Wolf,Jeanette A Maier,Andrea Rosanoff,Mario Barbagallo,Shadi Baniasadi,Sara Castiglioni,Fu-Chou Cheng,Sherrie Colaneri Day,Rebecca B Costello,Ligia J Dominguez,Ronald J Elin,Claudia Gamboa-Gomez,Fernando Guerrero-Romero,Ka Kahe,Klaus Kisters,Martin Kolisek,Anton Kraus,Stefano Iotti,Andre Mazur,Moises Mercado-Atri,Lucia Merolle,Oliver Micke,Nana Gletsu-Miller,Forrest Nielsen,Jin O-Uchi,Ornella
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Hospital-acquired dysmagnesemia and mortality in critically ill patients: data from MIMIC-III database Magnes. Res. (IF 3.2) Pub Date : 2021-04-01 Meng-Meng Zhang, Mei-Jing Ji, Xiao-Ming Wang, Si-Qiong Wang, Jing Sun, Chun-Ming Ma
The findings revealed that 27.2% of patients developed hospital-acquired dysmagnesemia. In-hospital mortalities were 8.8% in patients with persistently normal serum magnesium levels, 12.2% in patients with hospital-acquired hypomagnesemia only, 18.4% in patients with hospital-acquired hypermagnesemia only, and 20.6% in patients with both hospital-acquired hypomagnesemia and hypermagnesemia. Compared
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Dietary recommendations of magnesium for cardiovascular prevention and treatment. A position paper of the Israel Heart Society and the Israel Dietetic Association Magnes. Res. (IF 3.2) Pub Date : 2021-04-01 Michael Shechter, Sigal Eilat-Adar
Modern life and the Western industrial diet has enhanced the reduction of magnesium in our food, which may contribute to a marginal or absolute magnesium deficiency. Magnesium deficiency is evident in, among others, the elderly population, those after myocardial infarction and/or chronic heart failure, and diabetics. In Israel, over 60% of the drinking water originates from desalinated seawater lacking
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Serum magnesium: time for a standardized and evidence-based reference range Magnes. Res. (IF 3.2) Pub Date : 2021-04-01 Oliver Micke, Jürgen Vormann, Anton Kraus, Klaus Kisters
Magnesium deficiency can have serious health consequences. Low magnesium intake or low serum levels are risk factors for e.g. type 2 diabetes and cardiovascular diseases. Despite its scientifically recognized importance, too little attention is paid to magnesium in clinical practice. This may be due to the fact that there is no uniform and evidence-based reference range for serum magnesium as is the
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Development, optimization and characterization of chewable tablet containing synergistic combination of magnesium orotate dihydrate with cholecalciferol and menaquinone-7 for management of hyperglycemia and its pharmacokinetic study Magnes. Res. (IF 3.2) Pub Date : 2021-04-01 Hitesh Verma, Rajeev Garg
The objective of the present research is to develop and optimize a chewable tablet containing synergistic combination of magnesium orotate dihydrate (MOD), cholecalciferol (CHOL) and menaquinone-7 (MK-7) as per product development guidelines of ICH Q8 (R2). The effects of critical variables on quality attributes of chewable tablets were evaluated using 30 runs based design of experiment (DoE) after
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Magnesium enhances cardiomyocyte proliferation and suppresses cardiac fibrosis induced by chronic ACTH exposure in rats Magnes. Res. (IF 3.2) Pub Date : 2021-04-01 Jelena Petrović, Milica Labudović-Borović, Sabine U. Vorrink, Volker M. Lauschke, Bojana Pejušković, Vesna Pešić
Chronic stress has been implicated in the development and progression of heart disease. In the past decade, a link between chronic stress and cardiac fibrosis has been described. Here, we focused on investigating the effects of one of the key molecular effectors of the stress response–adrenocorticotropic hormone (ACTH) on cardiac histopathology. More importantly, as the literature data support interplay
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Magnesium therapeutic potential against Covid-19: Could it be an "All-in-one" therapy? Magnes. Res. (IF 3.2) Pub Date : 2021-02-11 Mourad Errasfa
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Rates of hypomagnesemia and hypermagnesemia in medical settings Magnes. Res. (IF 3.2) Pub Date : 2021-01-01 Antonino Catalano, Federica Bellone, Diego Chilà, Saverio Loddo, Nunziata Morabito, Giorgio Basile, Salvatore Benvenga, Francesco Corica
Magnesium (Mg) is critically involved in the pathophysiology of multiple human diseases; nevertheless, Mg disorders are often poorly considered in the clinical practice. To update the prevalence and incidence of hypomagnesemia and hypermagnesemia in a real-life scenario, which better represents clinical practice, we analyzed data from 12,696 patients whose Mg serum levels were measured from January
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Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats Magnes. Res. (IF 3.2) Pub Date : 2021-01-01 Kazim Sahin, Cemal Orhan, Osman Kucuk, Fusun Erten, Mehmet Tuzcu, Nurhan Sahin, Sara Perez Ojalvo, James Richard Komorowski
The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1, or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg
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Renal function, serum magnesium levels and mortality in COVID-19 patients with type 2 diabetes Magnes. Res. (IF 3.2) Pub Date : 2021-01-01 Patricia Pulido-Perez, Jorge Alberto Pondigo-de los Angeles, Maria Elena Hernandez-Hernandez, Enrique Torres-Rasgado, Jose R. Romero
T2D patients had lower eGFR and serum magnesium levels when compared to non-diabetics (59.7 ± 32.8 vs. 78.4 ± 33.8 mL/min per 1.73 m2, P = 0.008 and 1.9 ± 0.3 vs. 2.1 ± 0.3 mEq/L, P = 0.012). Survival was worse in T2D patients with eGFR levels less than 60 mL/min per 1.73 m2 as estimated by Kaplan-Meier analyses (log-rank test <0.0001). The Cox model for T2D patients showed that eGFR (HR 0.970, 95%
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Magnesium therapeutic potential against Covid-19: Could it be an “All-in-one” therapy? Magnes. Res. (IF 3.2) Pub Date : 2021-01-01 Mourad Errasfa
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Evaluation of synergistic combination comprising magnesium orotate, menaquinone-7, and cholecalciferol for management of type 2 diabetes and dyslipidemia Magnes. Res. (IF 3.2) Pub Date : 2020-10-01 Hitesh Verma, Rajeev Garg
Epidemiological outburst of type 2 diabetes is of great global concern. T2D starts with Insulin Resistance (IR) which arises largely due to environmental factors and to a lesser extent due to genetic factor. IR gradually develops into T2D and encompasses a wide array of conditions including Impaired Glucose Tolerance (IGT), hyperinsulinemia, Impaired Fasting Glucose (IFG), and Impaired Insulin Release
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Effect of oral administration of Magnesium N-Acetyltaurinate on synaptic plasticity in rodents Magnes. Res. (IF 3.2) Pub Date : 2020-10-01 Manon Fassin, Philippe Danhier, Laurence Ris
7-10-months-old transgenic APP/PS1 mice, a model of Alzheimer's disease, received ATA Mg® during 24 days at a dose of 700 mg/kg bw/day which is the dose used in previous studies demonstrating the positive effect of magnesium supplementation. We showed that long-term potentiation was significantly improved in the treated mice. Moreover, the expression of NR2B subunit of NMDA receptors, known to be involved
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Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors Magnes. Res. (IF 3.2) Pub Date : 2020-10-01 Didier Quilliot, Olivier Bonsack, Roland Jaussaud, André Mazur
Hypomagnesemia and hypermagnesemia could have serious implications and possibly lead to progress from a mild form to a severe outcome of Covid-19. Susceptibility of subjects with low magnesium status to develop and enhance this infection is possible. There is little data on the magnesium status of patients with Covid-19 with different degrees of severity. This study was conducted to evaluate prevalence
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Serum magnesium concentration may predict no-reflow phenomenon in primary angioplasty for ST-elevation myocardial infarction Magnes. Res. (IF 3.2) Pub Date : 2020-10-01 Eser Açıkgöz, Sadık Kadri Açıkgöz, Gökhan Çiçek
No-reflow phenomenon is a serious complication of percutaneous coronary intervention. Magnesium may play a role in pathogenesis of no-reflow phenomenon since it interacts with processes like platelet inhibition and endothelial-dependent vasodilatation. Relationship of serum magnesium concentration at admission and angiographic no-reflow phenomenon in ST elevation myocardial infarction patients undergoing
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Increased serum vitamin D concentration under oral magnesium therapy in elderly hypertensives Magnes. Res. (IF 3.2) Pub Date : 2020-10-01 K. Kisters, L. Kisters, T. Werner, A. Deutsch, T. Westhoff, U. Gröber
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Impact of magnesium supplementation, in combination with vitamin B6, on stress and magnesium status: secondary data from a randomized controlled trial Magnes. Res. (IF 3.2) Pub Date : 2020-07-01 Lionel Noah, Gisele Pickering, Andre Mazur, Claude Dubray, Simon Hitier, Christian Dualé, Etienne Pouteau
Background Primary findings from a recent study reported that magnesium supplementation significantly reduced stress in severely stressed subjects with low magnesemia, and additional vitamin B6 enhanced this effect. The mechanism by which combining magnesium and vitamin B6 leads to reduced stress in these subjects remains to be elucidated. This secondary analysis investigated the impact of magnesium
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miR-199a-5p targeted regulation of MAGT1 expression in the functional depletion of CD8+T cells in HBV infection Magnes. Res. (IF 3.2) Pub Date : 2020-07-01 Qiong Mo, Zilin Yuan, Lifen Ning, Gang Wang, Qili Luo, Bo Diao
Magnesium transporter 1 (MAGT1) is a key protein that regulates the level of free Mg2+ in cells. Previous studies found that the downregulation of MAGT1 expression in CD8+T cells of HBV patients was correlated with the decrease of intracellular magnesium. However, the expression of MAGT1 mRNA in the CD8+T cells from HBV patients was not significantly altered, indicating that the change in MAGT1 expression
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Magnesium deficiency with high calcium-to-magnesium ratio promotes a metastatic phenotype in the CT26 colon cancer cell line Magnes. Res. (IF 3.2) Pub Date : 2020-07-01 Gopal Kumar, Prodyot K. Chatterjee, Swati Madankumar, Syed F. Mehdi, Xiangying Xue, Christine N. Metz
Magnesium (Mg) plays important roles in maintaining genomic stability and cellular redox. Mg also serves as nature's physiological calcium (Ca) channel antagonist, controlling intracellular Ca entry. Because Ca is the most important second messenger, its intracellular concentration is tightly regulated. Excess intracellular Ca can activate aberrant signaling pathways leading to the acquisition of pathological
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Is Tirschenreuth the Colorado of Germany linking high COVID-19 mortality and low magnesium in drinking water? Magnes. Res. (IF 3.2) Pub Date : 2020-07-01 Bodo Von Ehrlich, Isabel Von Ehrlich
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Total serum and intraerythrocyte magnesium concentrations in hemodialysis patients using different dialysate solutions. Magnes. Res. (IF 3.2) Pub Date : 2020-04-01 Jovana Kusic,Rodoljub Markovic,Marija Andjelkovic Apostolovic,Gordana Dragovic
Background Beside routinely used 0.5 mmol/L dialysate-magnesium, higher dialysate-magnesium (1.0 mmol/L) was recently introduced. The aim of this study was to evaluate the impact of different dialysate-magnesium on serum and intraerythrocyte levels of magnesium (Mg) before and after dialysis.
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Dietary intake of magnesium in a type 1 diabetic pediatric population. Magnes. Res. (IF 3.2) Pub Date : 2020-04-01 Yasmine Benslama,Nouria Dennouni-Medjati,Majda Dali-Sahi,Soumia Kahloula,Ammaria Behar,Youssouf Kachekouche,Fatima Zahra Meziane,Yahia Harek
Several studies suggest the importance of adequate magnesium intake in the prevention of diabetes and/or its complications. The main objective of this study is to determine the daily dietary intake of magnesium in type 1 Algerian pediatric diabetics. The study involved a pediatric population of 201 individuals aged from 3 to 17 years, including 96 type 1 diabetics and 105 controls. The daily dietary
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The COVID-19 pandemic: is there a role for magnesium? Hypotheses and perspectives. Magnes. Res. (IF 3.2) Pub Date : 2020-04-01 Stefano Iotti,Federica Wolf,André Mazur,Jeanette A Maier
More and more studies are accumulating about COVID-19. Some aspects of the pathogenesis of the disease recall events occurring in Mg deficiency, such as a drop of T cells, increased plasma concentration of inflammatory cytokines, and endothelial dysfunction. We hypothesize that a low Mg status, which is rather common, might foment the transition from mild to critical clinical manifestations of the
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TRPM7 and MagT1 regulate the proliferation of osteoblast-like SaOS-2 cells through different mechanisms. Magnes. Res. (IF 3.2) Pub Date : 2020-01-01 M Zocchi,R Scrimieri,L Locatelli,A Cazzaniga,G Fedele,J A M Maier,S Castiglioni
A correct magnesium (Mg2+) intake is essential for bone health. In particular, Mg2+ deficiency inhibits the proliferation of osteoblast-like SaOS-2 cells by increasing nitric oxide (NO) production through the upregulation of inducible NO synthase. At the moment, little is known about the expression and the role of TRPM7, a channel/enzyme involved in Mg2+ uptake, and MagT1, a Mg2+ selective transporter
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The assessment of intracellular magnesium: different strategies to answer different questions. Magnes. Res. (IF 3.2) Pub Date : 2020-01-01 Giovanna Picone,Concettina Cappadone,Giovanna Farruggia,Emil Malucelli,Stefano Iotti
The role of magnesium in cell metabolism is complex and still not completely clarified. Although magnesium has been shown to modulate many phenomena in cells, its intracellular distribution and subcellular compartmentalization have not yet elucidated in detail, mainly as a consequence of the inadequacy of analytical techniques. The method usually employed to quantify total magnesium in cells or tissue
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Biopharmaceutics classification and pharmacokinetics study of magnesium orotate Magnes. Res. (IF 3.2) Pub Date : 2019-11-01 Hitesh Verma,Rajeev Garg
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Risk factors of hypomagnesemia in hospitalized patients with end-stage cancer Magnes. Res. (IF 3.2) Pub Date : 2019-11-01 Masahiro Takahashi
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The permeability of magnesium across the skin is enhanced by menthol cream Magnes. Res. (IF 3.2) Pub Date : 2019-11-01 Veera Turunen,Sirpa Peräniemi,Katariina Tolvanen,Merja Kokki,Marika Ruponen,Hannu Kokki