-
Molecular imaging of extracellular matrix proteins with targeted probes using magnetic resonance imaging. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-03-03 Mani Salarian,Oluwatosin Y Ibhagui,Jenny J Yang
The extracellular matrix (ECM) consists of proteins and carbohydrates that supports different biological structures and processes such as tissue development, elasticity, and preservation of organ structure. Diseases involving inflammation, fibrosis, tumor invasion, and injury are all attributed to the transition of the ECM from homeostasis to remodeling, which can significantly change the biochemical
-
Regulation of cancer-immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-03-01 Jingxing Yang,Chunfu Zhang
In the past decade, we have witnessed the revolution in cancer therapy, especially in the rapid development of cancer immunotherapy. In particular, the introduction of nanomedicine has achieved great improvement in breaking the limitations of and immunological tolerance caused by clinic-approved immunotherapies (cancer vaccine, CAR-T, and immune checkpoint blockade) to enhance immunogenicity, antigen
-
Recent advances of smart acid-responsive gold nanoparticles in tumor therapy. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-02-10 Yumin Zhang,Lijun Yang,Cuihong Yang,Jinjin Liu
Due to the remarkable properties of gold nanoparticles (AuNPs), they have been extensively employed as a potential tool for the diagnosis and treatment of cancers. While the conventional drug delivery system fails to efficiently deliver the chemotherapeutics due to the complexity of tumor microenvironment, people have been seeking alternative nanoparticulate strategy to improve the tumor specificity
-
Fluorescent carbon dots as intracellular imaging probes. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-02-10 Haydar Ali,Santu Ghosh,Nikhil R Jana
Fluorescent carbon dot has emerged as promising alternative of conventionally known quantum dot or molecular probe as potential intracellular imaging probe. In particular, <10 nm size, tunable and bright fluorescence of carbon dot deserve the application potential as intracellular imaging probe. However, synthesis of carbon dot with narrow particle size distribution, preparation of high-quality red/near-infrared
-
Recent advances in photoacoustic contrast agents for in vivo imaging. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-02-06 Paul Kumar Upputuri,Manojit Pramanik
Photoacoustic imaging (PAI) is a noninvasive hybrid imaging modality offering rich optical contrast and high depth-to-resolution ratio deep-tissue imaging. Endogenous chromophores present in the body such as hemoglobin, lipid, melanin, and so on provide strong photoacoustic contrast due to their strong light absorption in certain optical window. To enhance the performance of PAI further, researchers
-
Stimuli-activatable nanomedicines for chemodynamic therapy of cancer. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-02-03 Weiqi Wang,Yilan Jin,Zhiai Xu,Xiao Liu,Sadia Z Bajwa,Waheed S Khan,Haijun Yu
Chemodynamic therapy (CDT) takes the advantages of Fenton-type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable
-
Impact of the protein corona on nanomaterial immune response and targeting ability. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-01-30 Luca Digiacomo,Daniela Pozzi,Sara Palchetti,Alessandra Zingoni,Giulio Caracciolo
Over the last decade nanomaterials have had a major impact on human health for the early detection and treatment of many diseases. The future success of clinically translatable nanomaterials lies in the combination of several functionalities to realize a personalized medical experience for patients. To maintain promises, concerns arising from toxic potential and off-target accumulation of nanomaterials
-
Protein-based nanoplatforms for tumor imaging and therapy. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-01-30 Kaicheng Liang,Hangrong Chen
Cancer is one of the leading causes of death all over the world. The development of nanoplatform provides a promising strategy for the diagnosis and treatment of cancer. As the foundation of the nanoplatform, the composition of nanocarrier decides the basic properties. Protein exists in all kinds of life and participates in any life activities, having great potentials to serve as a nanocarrier because
-
Physical virology: From virus self-assembly to particle mechanics. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2020-01-20 Pedro Buzón,Sourav Maity,Wouter H Roos
Viruses are highly ordered supramolecular complexes that have evolved to propagate by hijacking the host cell's machinery. Although viruses are very diverse, spreading through cells of all kingdoms of life, they share common functions and properties. Next to the general interest in virology, fundamental viral mechanisms are of growing importance in other disciplines such as biomedicine and (bio)nanotechnology
-
Polymer-mediated gene therapy: Recent advances and merging of delivery techniques. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-12-02 Janelle W Salameh,Le Zhou,Sarah M Ward,Cristiam F Santa Chalarca,Todd Emrick,Marxa L Figueiredo
The ability to safely and precisely deliver genetic materials to target sites in complex biological environments is vital to the success of gene therapy. Numerous viral and nonviral vectors have been developed and evaluated for their safety and efficacy. This study will feature progress in synthetic polymers as nonviral vectors, which benefit from their chemical versatility, biocompatibility, and ability
-
Biocorona-induced modifications in engineered nanomaterial-cellular interactions impacting biomedical applications. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-12-01 Lisa Kobos,Jonathan Shannahan
When nanoparticles (NPs) enter a physiological environment, a complex coating of biomolecules is absorbed onto their surface, known as the biocorona (BC). This coating alters nanomaterial physical properties, modulating cellular viability, internalization, and immune responses. To safely utilize NPs within medical settings, it is necessary to understand the influence of the BC on cellular responses
-
Insight into the siRNA transmembrane delivery-From cholesterol conjugating to tagging. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-12-01 Yan Zheng,Wanyi Tai
Small interfering RNA (siRNA), combining the features of unprecedented potency, target-specificity, and the unique sequence-based disease-intervention model, has received immense considerations over the past decades in the academia and pharmaceutical industry. siRNA fits the criteria of being drug-likely enough to meet with the therapeutic purpose, but its clinical translation has been impeded for
-
Mixed-charge bionanointerfaces: Opposite charges work in harmony to meet the challenges in biomedical applications. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-11-28 Huan Li,Xu Li,Jian Ji
Understanding and regulation of the interfaces formed between materials and biological systems has been considered as one of the major tasks in nanotechnology, as the bionanointerfaces often exert profound effects on the fates and therapeutic outcomes of nanomaterials. In the last decades, materials with mixed-charge surfaces have witnessed fast development. The oppositely charged units on the materials'
-
Protein-protected metal nanoclusters: An emerging ultra-small nanozyme. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-11-14 Xiangqin Meng,Iman Zare,Xiyun Yan,Kelong Fan
Protein-protected metal nanoclusters (MNCs), typically consisting of several to a hundred metal atoms with a protein outer layer used for protecting clusters from aggregation, are excellent fluorescent labels for biomedical applications due to their extraordinary photoluminescence, facile synthesis and good biocompatibility. Interestingly, many protein-protected MNCs have also been reported to exhibit
-
Nanotechnology platforms for cancer immunotherapy. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-11-07 Zhaogang Yang,Yifan Ma,Hai Zhao,Yuan Yuan,Betty Y S Kim
Various cancer therapies have advanced remarkably over the past decade. Unlike the direct therapeutic targeting of tumor cells, cancer immunotherapy is a new strategy that boosts the host's immune system to detect specific cancer cells for efficient elimination. Nanoparticles incorporating immunomodulatory agents can activate immune cells and modulate the tumor microenvironment to enhance antitumor
-
Nanocarriers in photodynamic therapy-in vitro and in vivo studies. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-11-06 Krzysztof Sztandera,Michał Gorzkiewicz,Barbara Klajnert-Maculewicz
Photodynamic therapy (PDT) is a minimally invasive technique which has proven to be successful in the treatment of several types of tumors. This relatively simple method exploits three inseparable elements: phototoxic compound (photosensitizer [PS]), light source, and oxygen. Upon irradiation by light with specified wavelength, PS generates reactive oxygen species, which starts the cascade of reactions
-
Multifluid electrospinning for the generation of complex nanostructures. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-11-06 Deng-Guang Yu,Menglong Wang,Xiaoyan Li,Xinkuan Liu,Li-Min Zhu,Sim Wan Annie Bligh
New nanostructure means new nanotechnology and nanoscience. The need of complex nanostructure-based advanced functional nanomaterials has promoted the appearance of several kinds of multifluid electrospinning processes, such as tri-axial electrospinning, quad-fluid coaxial electrospinning, tri-fluid side-by-side electrospinning, and coaxial electrospinning with a side-by-side core. These multifluid
-
Recent advancements in two-dimensional nanomaterials for drug delivery. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-10-25 Xuan Mei,Tingting Hu,Yingjie Wang,Xisheng Weng,Ruizheng Liang,Min Wei
Different from conventional zero-dimensional (0D) and one-dimensional (1D) counterparts, two-dimensional (2D) nanomaterials show unique properties resulting from their specific structure and morphology. In recent years, broad interest has been focused on the exploration of 2D nanomaterials for drug delivery, which benefits greatly to various disease treatments due to the superior properties of 2D nanomaterials
-
Theranostic small interfering RNA nanoparticles in cancer precision nanomedicine. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-10-23 Zhihang Chen,Balaji Krishnamachary,Jesus Pachecho-Torres,Marie-France Penet,Zaver M Bhujwalla
Due to their ability to effectively downregulate the expression of target genes, small interfering RNA (siRNA) have emerged as promising candidates for precision medicine in cancer. Although some siRNA-based treatments have advanced to clinical trials, challenges such as poor stability during circulation, and less than optimal pharmacokinetics and biodistribution of siRNA in vivo present barriers to
-
From stars to stripes: RNA-directed shaping of plant viral protein templates-structural synthetic virology for smart biohybrid nanostructures. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-10-20 Christina Wege,Claudia Koch
The self-assembly of viral building blocks bears exciting prospects for fabricating new types of bionanoparticles with multivalent protein shells. These enable a spatially controlled immobilization of functionalities at highest surface densities-an increasing demand worldwide for applications from vaccination to tissue engineering, biocatalysis, and sensing. Certain plant viruses hold particular promise
-
Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-10-10 Caleb F Anderson,Maria E Grimmett,Christopher J Domalewski,Honggang Cui
Respiratory illnesses are prevalent around the world, and inhalation-based therapies provide an attractive, noninvasive means of directly delivering therapeutic agents to their site of action to improve treatment efficacy and limit adverse systemic side effects. Recent trends in medicine and nanoscience have prompted the development of inhalable nanomedicines to further enhance effectiveness, patient
-
The potential anti-infective applications of metal oxide nanoparticles: A systematic review. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-10-08 Yasmin Abo-Zeid,Gareth R Williams
Microbial infections present a major global healthcare challenge, in large part because of the development of microbial resistance to the currently approved antimicrobial drugs. This demands the development of new antimicrobial agents. Metal oxide nanoparticles (MONPs) are a class of materials that have been widely explored for diagnostic and therapeutic purposes. They are reported to have wide-ranging
-
Polymer-based activatable optical probes for tumor fluorescence and photoacoustic imaging. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-10-03 Xu Zhen,Xiqun Jiang
Optical imaging including fluorescence imaging and photoacoustic imaging have been widely employed in early and accurate diagnosis of cancer. Compared to the "always on" optical probes, the molecular probes that could emit their signal in response to the tumor microenvironment exhibit the low background noise and high signal-to-background ratio, allowing sensitive and accurate cancer diagnosis. Polymer-based
-
Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-09-30 Jie Zhao,Li Duan,Anhe Wang,Jinbo Fei,Junbai Li
Photodynamic therapy (PDT) has been used in the treatment of cancers and other benign diseases for several years in clinic. However, the hypoxia of tumors and the penetration limitation of excitation light to tissues can dramatically reduce the efficacy of PDT to cancers. To overcome these drawbacks, various assembled nanocarriers such as nanoparticles, nanocapsules, nanocrystals, and so on were introduced
-
The role of sex in particle-induced inflammation and injury. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-09-30 Jessica L Ray,Paige Fletcher,Rachel Burmeister,Andrij Holian
The use of engineered nanomaterials within various applications such as medicine, electronics, and cosmetics has been steadily increasing; therefore, the rate of occupational and environmental exposures has also increased. Inhalation is an important route of exposure to nanomaterials and has been shown to cause various respiratory diseases in animal models. Human lung disease frequently presents with
-
Critical considerations for targeting colorectal liver metastases with nanotechnology. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-09-30 Usman Arshad,Paul A Sutton,Marianne B Ashford,Kevin E Treacher,Neill J Liptrott,Steve P Rannard,Christopher E Goldring,Andrew Owen
Colorectal cancer remains a significant cause of morbidity and mortality worldwide. Half of all patients develop liver metastases, presenting unique challenges for their treatment. The shortcomings of conventional chemotherapy has encouraged the use of nanomedicines; the application of nanotechnology in the diagnosis and treatment of disease. In spite of technological improvements in nanotechnology
-
Advances of functional nanomaterials for cancer immunotherapeutic applications. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-09-30 Yuhao Hao,Xingyu Zhou,Rui Li,Zechenxi Song,Yuanzeng Min
Immunotherapy has made great progress by modulating the body's own immune system to fight against cancer cells. However, the low response rates of related drugs limit the development of immunotherapy strategies. Fortunately, the advantages of nanotechnology can just make up for this shortcoming. Nanocarriers of diverse systems are utilized to co-deliver antigens and adjuvants, combined with drugs for
-
Single and multiple detections of foodborne pathogens by gold nanoparticle assays. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-09-18 Dakrong Pissuwan,Camilla Gazzana,Skorn Mongkolsuk,Michael B Cortie
A late detection of pathogenic microorganisms in food and drinking water has a high potential to cause adverse health impacts in those who have ingested the pathogens. For this reason there is intense interest in developing precise, rapid and sensitive assays that can detect multiple foodborne pathogens. Such assays would be valuable components in the campaign to minimize foodborne illness. Here, we
-
Plant molecular farming of virus-like nanoparticles as vaccines and reagents. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-09-05 Edward P Rybicki
The use of plants for the production of virus-like nanoparticles (VNPs) dates back to separating natural empty capsids of plant viruses from whole virions nearly 70 years ago, through to the present use of transgenic plants or recombinant Agrobacterium tumefaciens and/or plant virus-derived vectors for the transient expression of engineered viral or other structural proteins in plants-a production
-
Integration of gadolinium in nanostructure for contrast enhanced-magnetic resonance imaging. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-09-05 Ramesh Marasini,Tuyen Duong Thanh Nguyen,Santosh Aryal
Magnetic resonance imaging (MRI) is a routinely used imaging technique in medical diagnostics, which is further enhanced with the use of contrast agents (CAs). The most commonly used CAs are gadolinium-based contrast agents (GBCAs), in which gadolinium (Gd) is chelated with organic chelating agents (linear or cyclic). However, the use of GBCA is related to toxic side effect due to the release of free
-
Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-08-27 Sijin Guo,Congcong Xu,Hongran Yin,Jordan Hill,Fengmei Pi,Peixuan Guo
The past decade has shown exponential growth in the field of RNA nanotechnology. The rapid advances of using RNA nanoparticles for biomedical applications, especially targeted cancer therapy, suggest its potential as a new generation of drug. After the first milestone of small molecule drugs and the second milestone of antibody drugs, it was predicted that RNA drugs, either RNA itself or chemicals/ligands
-
Virus-like particles for vaccination against cancer. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-08-27 Mona O Mohsen,Daniel E Speiser,Alexander Knuth,Martin F Bachmann
Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and humoral immune responses. Virus-like particle-based vaccines have evolved dramatically over the last few decades, greatly reducing morbidity and mortality of several infectious diseases and expectedly preventing cervical cancer caused by human papilloma virus. In contrast to these broad successes of disease
-
Block copolymer prodrugs: Synthesis, self-assembly, and applications for cancer therapy. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-08-26 Debabrata Dutta,Wendong Ke,Longchang Xi,Wei Yin,Min Zhou,Zhishen Ge
Block copolymer prodrugs (BCPs) have emerged as one of the most promising anticancer drug delivery strategies, which can self-assemble into nanoparticles with optimal physicochemical properties including sizes, morphologies, surface properties, and integration of multifunction for improved in vivo applications. Moreover, the utility of stimuli-responsive linkages to conjugate drugs onto the polymer
-
Physical-, chemical-, and biological-responsive nanomedicine for cancer therapy. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-08-19 Jinfeng Liao,Yanpeng Jia,Yongzhi Wu,Kun Shi,Dawei Yang,Pei Li,Zhiyong Qian
Cancer therapy is unsatisfactory as it typically has serious side effects, because normal cells in healthy organs are destroyed along with the tumor. Thus, researchers have tried to develop effective therapies with minimal side effects. One such method is to use nanotechnology to carry the drugs or therapeutic agents to the tumor region by secure encapsulation without leakage. Once the nanomedicine
-
Highly ordered protein cage assemblies: A toolkit for new materials. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-08-14 Antti Korpi,Eduardo Anaya-Plaza,Salla Välimäki,Mauri Kostiainen
Protein capsids are specialized and versatile natural macromolecules with exceptional properties. Their homogenous, spherical, rod-like or toroidal geometry, and spatially directed functionalities make them intriguing building blocks for self-assembled nanostructures. High degrees of functionality and modifiability allow for their assembly via non-covalent interactions, such as electrostatic and coordination
-
Immunoengineering in glioblastoma imaging and therapy. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-08-12 Steven Zanganeh,Petrina Georgala,Claudia Corbo,Leila Arabi,Jim Q Ho,Najme Javdani,Mohammad R Sepand,Kiara Cruickshank,Luis F Campesato,Chien-Huan Weng,Saeed Hemayat,Chrysafis Andreou,Ricardo Alvim,Gregor Hutter,Marjan Rafat,Morteza Mahmoudi
Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on healthy tissues. A central challenge in treating brain tumors is the poor permeability of the blood-brain barrier (BBB) to therapeutics. Recently, various methods based on immunotherapy
-
Metal-based phosphorus dendrimers as novel nanotherapeutic strategies to tackle cancers: A concise overview. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-08-07 Liang Chen,Serge Mignani,Anne-Marie Caminade,Jean-Pierre Majoral
Several metal-based phosphorus dendrimers were prepared. The first series developed by us was the Cu(II) series. In this series, the most potent is the third generation-Cu(II) showing original mechanism of action with activation of the pro-apoptotic Bax protein. To our knowledge, it is the first example of nanoparticles displaying Bax protein activation and then cell death through apoptosis process
-
Advances of nanotechnology in osteochondral regeneration. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-07-22 Cuijun Deng,Chang Xu,Quan Zhou,Yu Cheng
In the past few decades, nanotechnology has proven to be one of the most powerful engineering strategies. The nanotechnologies for osteochondral tissue engineering aim to restore the anatomical structures and physiological functions of cartilage, subchondral bone, and osteochondral interface. As subchondral bone and articular cartilage have different anatomical structures and the physiological functions
-
Mesoporous silica nanoparticles for tissue-engineering applications. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-07-11 Liang Chen,Xiaojun Zhou,Chuanglong He
Mesoporous silica nanoparticles (MSNs) have been widely investigated as a nanocarrier for the delivery of various cargoes in nanomedicine. The application of MSNs in tissue engineering is a relatively newly emerged field that has gained much research interest. In this review, the recent advances in the tissue-engineering application of MSNs are summarized. The controlled synthesis of MSNs is delineated
-
National Cancer Institute Alliance for nanotechnology in cancer-Catalyzing research and translation toward novel cancer diagnostics and therapeutics. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-07-01 Christopher M Hartshorn,Luisa M Russell,Piotr Grodzinski
Nanotechnology has been a burgeoning research field, which is finding compelling applications in several practical areas of everyday life. It has provided novel, paradigm shifting solutions to medical problems and particularly to cancer. In order to accelerate integration of nanotechnology into cancer research and oncology, the National Cancer Institute (NCI) of the National Institutes of Health (NIH)
-
Quantum dots from microfluidics for nanomedical application. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-07-01 Feika Bian,Lingyu Sun,Lijun Cai,Yu Wang,Yuanjin Zhao
Nanomedicine, with its advantages of rapid diagnosis, high sensitivity and high accuracy, has aroused extensive interest of researchers, as the cornerstone of nanomedicine, nanomaterials achieve extra attention and rapid development. Among nanomaterials, quantum dots stand out due to their long fluorescence lifetime and excellent antiphotobleaching performance. At present, quantum dots have been applied
-
The consolidation of nanomedicine. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-06-26 Raphael Zingg,Marius Fischer
Over the past two decades, nanomedicine has grown steadily, however, without inducing a palpable shift in the diagnosis and treatment of diseases so far. While this may simply be a consequence of the slow, incremental nature that characterizes many modern technologies, this article posits that there is another set of significant factors harboring explanatory power. Uncertainties concerning safety,
-
Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-06-26 Jessica F Liu,Bian Jang,David Issadore,Andrew Tsourkas
Drug delivery strategies aim to maximize a drug's therapeutic index by increasing the concentration of drug at target sites while minimizing delivery to off-target tissues. Because biological tissues are minimally responsive to magnetic fields, there has been a great deal of interest in using magnetic nanoparticles in combination with applied magnetic fields to selectively control the accumulation
-
Electroconductive hydrogels for biomedical applications. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-06-26 Han Lu,Ning Zhang,Mingming Ma
Electroconductive hydrogels (EHs), combining both the biomimetic features of hydrogels and the electrochemical properties of conductive polymers and carbon-based materials, have received immense considerations over the past decade. The three-dimensional porous structure, hydrophilic properties, and regulatable chemical and physical properties of EH resemble the extracellular matrix in tissues, enable
-
Nanovaccines for cancer immunotherapy. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-06-06 Yu Zhang,Shuibin Lin,Xiang-Yang Wang,Guizhi Zhu
The past few decades have witnessed the booming field of cancer immunotherapy. Cancer therapeutic vaccines, either alone or in combination with other immunotherapies such as adoptive cell therapy or immune checkpoint blockade therapy, are an attractive class of cancer immunotherapeutics. However, cancer vaccines have thus far shown suboptimal efficacy in the clinic. Nanomedicines offer unique opportunities
-
Carbohydrate-based nanomaterials for biomedical applications. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-05-07 Soeun Gim,Yuntao Zhu,Peter H Seeberger,Martina Delbianco
Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple mono- or disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based
-
Recent advances in photodynamic therapy for cancer and infectious diseases. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-05-06 Xutong Shi,Can Yang Zhang,Jin Gao,Zhenjia Wang
Photodynamic therapy (PDT) is a treatment by combining light and a photosensitizer to generate reactive oxygen species (ROS) for cellular damage, and is used to treat cancer and infectious diseases. In this review, we focus on recent advances in design of new photosensitizers for increased production of ROS and in genetic engineering of biological photosensitizers to study cellular signaling pathways
-
Cascade-amplification of therapeutic efficacy: An emerging opportunity in cancer treatment. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-04-23 Menghuan Li,Zhong Luo,Zhihong Peng,Kaiyong Cai
Increasing research evidence reveals that cancer is complex disease involving many biological factors, processes and systems, which may severely limit the actual efficacy of conventional monotonic anticancer approaches. To overcome these obstacles in cancer treatment, a new strategy has been proposed by combining multiple synergistic therapeutic modalities accessing different but inherently related
-
Applications of molecular engineering in T-cell-based immunotherapies. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-04-10 David A McBride,Matthew D Kerr,Shinya L Wai,Nisarg J Shah
Harnessing an individual's immune cells to mediate antitumor and antiviral responses is a life-saving option for some patients with otherwise intractable forms of cancer and infectious disease. In particular, T-cell-based engineered immune cells are a powerful new class of therapeutics with remarkable efficacy. Clinical experience has helped to define some of the major challenges for reliable, safe
-
Antibody and antibody derivatives as cancer therapeutics. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-04-09 Keith J Arlotta,Shawn C Owen
Antibodies are an important class of therapeutic for treating a wide range of diseases. These versatile macromolecules can be engineered to target many different antigens and to utilize several mechanisms of action to produce a pharmacological effect. The most common antibody platform used for therapeutics is immunoglobulin G (IgG). Advances in protein-display and genetic engineering have enabled the
-
Integration of target discovery, drug discovery and drug delivery: A review on computational strategies. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-04-01 Yorley Duarte,Valeria Márquez-Miranda,Matthieu J Miossec,Fernando González-Nilo
Most of the computational tools involved in drug discovery developed during the 1980s were largely based on computational chemistry, quantitative structure-activity relationship (QSAR) and cheminformatics. Subsequently, the advent of genomics in the 2000s gave rise to a huge number of databases and computational tools developed to analyze large quantities of data, through bioinformatics, to obtain
-
From isolated structures to continuous networks: A categorization of cytoskeleton-based motile engineered biological microstructures. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-02-11 Rachel Andorfer,Joshua D Alper
As technology at the small scale is advancing, motile engineered microstructures are becoming useful in drug delivery, biomedicine, and lab-on-a-chip devices. However, traditional engineering methods and materials can be inefficient or functionally inadequate for small-scale applications. Increasingly, researchers are turning to the biology of the cytoskeleton, including microtubules, actin filaments
-
Magnetic resonance imaging of stem cell-macrophage interactions with ferumoxytol and ferumoxytol-derived nanoparticles. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-02-07 Hossein Nejadnik,Jessica Tseng,Heike Daldrup-Link
"Off the shelf" allogeneic stem cell transplants and stem cell nano-composites are being used for the treatment of degenerative bone diseases. However, major and minor histocompatibility antigens of therapeutic cell transplants can be recognized as foreign and lead to their rejection by the host immune system. If a host immune response is identified within the first week post-transplant, immune modulating
-
Sugar-based biopolymers as novel imaging agents for molecular magnetic resonance imaging. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2019-01-22 Zheng Han,Guanshu Liu
Sugar-based biopolymers have been recognized as attractive materials to develop macromolecule- and nanoparticle-based cancer imaging and therapy. However, traditional biopolymer-based imaging approaches rely on the use of synthetic or isotopic labeling, and because of it, clinical translation often is hindered. Recently, a novel magnetic resonance imaging (MRI) technology, chemical exchange saturation
-
Overview of the blood compatibility of nanomedicines: A trend analysis of in vitro and in vivo studies. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2018-12-17 Patricia Urbán,Neill J Liptrott,Susanne Bremer
As nanomedicines have the potential to address many currently unmet medical needs, the early identification of regulatory requirements that could hamper a smooth translation of nanomedicines from the laboratory environment to clinical applications is of utmost importance. The blood system is especially relevant as many nanomedicinal products that are currently under development are designed for intravenous
-
Fundamentals, challenges, and nanomedicine-based solutions for ocular diseases. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2018-12-03 Dadi A Srinivasarao,Garima Lohiya,Dhirendra S Katti
The eye consists of sensitive, compactly adjoined tissue structures which act as strong physical (static) and physiological (dynamic) barriers that prevent entry of foreign bodies into the eye. Together, these barriers reduce the bioavailability of topically and intraocularly administered medicaments thus demanding frequent drug administration for the treatment of chronic eye diseases. Hence, development
-
Protein crystal based materials for nanoscale applications in medicine and biotechnology. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2018-11-28 Luke F Hartje,Christopher D Snow
The porosity, order, biocompatibility, and chirality of protein crystals has motivated interest from diverse research domains including materials science, biotechnology, and medicine. Porous protein crystals have the unusual potential to organize guest molecules within highly ordered scaffolds, enabling applications ranging from biotemplating and catalysis to biosensing and drug delivery. Significant
-
Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2018-11-08 Maria Yanqing Chen,Susan S Butler,Weitong Chen,Junghae Suh
The fields of physical, chemical, and synthetic virology work in partnership to reprogram viruses as controllable nanodevices. Physical virology provides the fundamental biophysical understanding of how virus capsids assemble, disassemble, display metastability, and assume various configurations. Chemical virology considers the virus capsid as a chemically addressable structure, providing chemical
-
Probing the biological obstacles of nanomedicine with gold nanoparticles. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2018-08-07 Bin Li,Lucas A Lane
Despite massive growth in nanomedicine research to date, the field still lacks fundamental understanding of how certain physical and chemical features of a nanoparticle affect its ability to overcome biological obstacles in vivo and reach its intended target. To gain fundamental understanding of how physical and chemical parameters affect the biological outcomes of administered nanoparticles, model
-
Targeted siRNA delivery using aptamer-siRNA chimeras and aptamer-conjugated nanoparticles. WIREs Nanomed. Nanobiotechnol. (IF 7.689) Pub Date : 2018-08-02 Padmanaban Sivakumar,Sumin Kim,Han Chang Kang,Min Suk Shim
The sequence-specific gene-silencing ability of small interfering RNA (siRNA) has been exploited as a new therapeutic approach for the treatment of a variety of diseases. However, efficient and safe delivery of siRNA into target cells is still a challenge in the clinical development of siRNA-based therapeutics. Recently, nucleic acid-based aptamers that target cell surface proteins have emerged as
Contents have been reproduced by permission of the publishers.