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HDAC inhibitors Tubastatin A and SAHA affect parasite cell division and are potential anti-Toxoplasma gondii chemotherapeutics Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-12-17 Carlla Assis Araujo-Silva; Wanderley De Souza; Erica S. Martins-Duarte; Rossiane C. Vommaro
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Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-12-05 Marcelo U. Ferreira; Tais Nobrega de Sousa; Gabriel W. Rangel; Igor C. Johansen; Rodrigo M. Corder; Simone Ladeia-Andrade; José Pedro Gil
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Recording drug responses from adult Dirofilaria immitis pharyngeal and somatic muscle cells Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-12-13 S. Verma; D. Kulke; J.W. McCall; R.J. Martin; A.P. Robertson
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Artemisinin-based combination therapy (ACT) and drug resistance molecular markers: A systematic review of clinical studies from two malaria endemic regions – India and sub Saharan Africa Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-12-13 Aditi Arya; Loick P. Kojom Foko; Shewta Chaudhry; Vineeta Singh
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Challenges and opportunities for the adoption of molecular diagnostics for anthelmintic resistance Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-12-02 Andrew C. Kotze; John S. Gilleard; Stephen R. Doyle; Roger K. Prichard
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Detection of target-site and metabolic resistance to pyrethroids in the bed bug Cimex lectularius in Berlin, Germany1 Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-11-20 Arlette Vander Pan; Carola Kuhn; Erik Schmolz; Georg von Samson-Himmelstjerna; Jürgen Krücken
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A retrospective cohort study of the effectiveness and adverse events of intralesional pentavalent antimonials in the treatment of cutaneous leishmaniasis Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-11-19 Bruna Côrtes Rodrigues; Marina Freitas Ferreira; Daniel Holanda Barroso; Jorgeth Oliveira Carneiro da Motta; Carmen Déa Ribeiro de Paula; Cláudia Porto; Sofia Sales Martins; Ciro Martins Gomes; Raimunda Nonata Ribeiro Sampaio
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An ELISA method to assess HDAC inhibitor-induced alterations to P. falciparum histone lysine acetylation Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-11-02 Eva Hesping; Tina S. Skinner-Adams; Gillian M. Fisher; Thomas Kurz; Katherine T. Andrews
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Caenorhabditis elegans in anthelmintic research – Old model, new perspectives Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-02 Steffen R. Hahnel; Clayton M. Dilks; Iring Heisler; Erik C. Andersen; Daniel Kulke
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A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-11-19 John Sanders; Yue Xie; David Gazzola; Hanchen Li; Ambily Abraham; Kelly Flanagan; Florentina Rus; Melanie Miller; Yan Hu; Sierra Guynn; Austin Draper; Sridhar Vakalapudi; Katherine H. Petersson; Dante Zarlenga; Robert W. Li; Joseph F. Urban; Gary R. Ostroff; Anne Zajac; Raffi V. Aroian
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Curcuma longa rhizome extract and Curcumin reduce the adhesion of Acanthamoeba triangularis trophozoites and cysts in polystyrene plastic surface and contact lens Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-11-17 Watcharapong Mitsuwan; Suthinee Sangkanu; Chonticha Romyasamit; Chalermpon Kaewjai; Tajudeen O. Jimoh; Maria de Lourdes Pereira; Abolghasem Siyadatpanah; Sunil Kayesth; Muhammad Nawaz; Mohammed Rahmatullah; Mark S. Butler; Polrat Wilairatana; Christophe Wiart; Veeranoot Nissapatorn
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Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-27 Sean T. Windle; Kristin D. Lane; Nahla B. Gadalla; Anna Liu; Jianbing Mu; Ramoncito L. Caleon; Rifat S. Rahman; Juliana M. Sá; Thomas E. Wellems
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Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-31 Samya S. Alenezi; Manal J. Natto; John O. Igoli; Alexander I. Gray; James Fearnley; Hugo Fearnley; Harry P. de Koning; David G. Watson
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Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-29 Brad E. Sleebs; Kate E. Jarman; Sonja Frolich; Wilson Wong; Julie Healer; Weiwen Dai; Isabelle S. Lucet; Danny W. Wilson; Alan F. Cowman
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Copper detoxification machinery of the brain-eating amoeba Naegleria fowleri involves copper-translocating ATPase and the antioxidant system Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-07 Maria Grechnikova; Kateřina Ženíšková; Ronald Malych; Jan Mach; Robert Sutak
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In vitro evaluation of commercial foam Belcils® on Acanthamoeba spp Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-14 Ines Sifaoui; Iván Rodríguez-Talavera; María Reyes-Batlle; Rubén L. Rodríguez-Expósito; Pedro Rocha-Cabrera; José E. Piñero; Jacob Lorenzo-Morales
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Nicotinic acetylcholine receptors in the synganglion of the tick Ixodes ricinus: Functional characterization using membrane microtransplantation Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-16 Anaïs Le Mauff; Hamza Chouikh; Alison Cartereau; Claude L. Charvet; Cédric Neveu; Claude Rispe; Olivier Plantard; Emiliane Taillebois; Steeve H. Thany
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Route of administration influences the concentration of ivermectin reaching nematode parasites in the gastrointestinal tract of cattle Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-20 D.M. Leathwick; C.M. Miller; T.S. Waghorn; H. Schwendel; A. Lifschitz
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Nullscript inhibits Cryptosporidium and Toxoplasma growth Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-15 Fumi Murakoshi; Hironori Bando; Tatsuki Sugi; Oluyomi Stephen Adeyemi; Motohiro Nonaka; Takaaki Nakaya; Kentaro Kato
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Rapid determination of nematode cell and organ susceptibility to toxic treatments Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-20 Douglas P. Jasmer; Bruce A. Rosa; Rahul Tyagi; Makedonka Mitreva
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Evaluation of the therapeutic efficacy of praziquantel against schistosomes in seven countries with ongoing large-scale deworming programs Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-10-17 B. Levecke; J. Vlaminck; L. Andriamaro; S. Ame; V. Belizario; A. Degarege; D. Engels; B. Erko; A.D. Garba; G.M. Kaatano; Z. Mekonnen; A. Montresor; P. Olliaro; O.S. Pieri; M. Sacko; S.O. Sam-Wobo; L.A. Tchuem Tchuenté; J.P. Webster; J. Vercruysse
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The use of ITS-2 rDNA nemabiome metabarcoding to enhance anthelmintic resistance diagnosis and surveillance of ovine gastrointestinal nematodes Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-09-19 Camila Queiroz; Michel Levy; Russell Avramenko; Elizabeth Redman; Kelsey Kearns; Lana Swain; Haley Silas; Fabienne Uehlinger; John S. Gilleard
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Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-09-30 M.K. Nielsen; M. Banahan; R.M. Kaplan
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Novel acyl carbamates and acyl / diacyl ureas show in vitro efficacy against Toxoplasma gondii and Cryptosporidium parvum Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-08-25 Kun Li; Gregory M. Grooms; Shahbaz M. Khan; Anolan Garcia Hernandez; William H. Witola; Jozef Stec
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Activity of paromomycin against Leishmania amazonensis: Direct correlation between susceptibility in vitro and the treatment outcome in vivo Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-08-15 Elizabeth M. Coser; Bianca A. Ferreira; Nilson Branco; Edite H. Yamashiro-Kanashiro; José Angelo L. Lindoso; Adriano C. Coelho
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Climate change is likely to increase the development rate of anthelmintic resistance in equine cyathostomins in New Zealand Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-09-17 Christian W. Sauermann; Dave M. Leathwick; Mark Lieffering; Martin K. Nielsen
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New insights into the use of a mite count reduction test for the detection of therapeutic acaricide efficacy in Psoroptes ovis in cattle Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-09-20 Wouter van Mol; Edwin Claerebout; Stijn Casaert; Peter Geldhof; Bruno Levecke
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Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-08-15 Lizzi Herrera,Alejandro Llanes,Jennifer Álvarez,Kissy Degracia,Carlos M Restrepo,Rene Rivera,David E Stephens,Hang T Dang,Oleg V Larionov,Ricardo Lleonart,Patricia L Fernández
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RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-08-19 Paul McCusker,Wasim Hussain,Paul McVeigh,Erin McCammick,Nathan G Clarke,Emily Robb,Fiona M McKay,Peter M Brophy,David J Timson,Angela Mousley,Nikki J Marks,Aaron G Maule
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Reduced treatment frequencies with bumped kinase inhibitor 1369 are effective against porcine cystoisosporosis. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-08-21 Aruna Shrestha,Bärbel Ruttkowski,Patricia Greber,Grant R Whitman,Matthew A Hulverson,Ryan Choi,Samantha A Michaels,Kayode K Ojo,Wesley C Van Voorhis,Anja Joachim
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Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-08-20 Clayton M Dilks,Steffen R Hahnel,Qicong Sheng,Lijiang Long,Patrick T McGrath,Erik C Andersen
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Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-07-22 Alba Martínez-Flórez,Melina Galizzi,Luis Izquierdo,Juan M Bustamante,Ana Rodriguez,Fernando Rodriguez,Alhelí Rodríguez-Cortés,Jordi Alberola
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Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-07-29 Samantha A Nixon,Claudia Welz,Debra J Woods,Livio Costa-Junior,Mostafa Zamanian,Richard J Martin
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A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-07-25 Gregory D Bowden,Patricia M Reis,Maxwell B Rogers,Rachel M Bone Relat,Kelly A Brayton,Sarah K Wilson,Bruno Martorelli Di Genova,Laura J Knoll,Felix J Nepveux V,Albert K Tai,Timothy R Ramadhar,Jon Clardy,Roberta M O'Connor
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Drug repurposing applied: Activity of the anti-malarial mefloquine against Echinococcus multilocularis. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-07-02 Britta Lundström-Stadelmann,Reto Rufener,Andrew Hemphill
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Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-06-13 Caio H Franco,David C Warhurst,Tapan Bhattacharyya,Ho Y A Au,Hai Le,Miriam A Giardini,Bruno S Pascoalino,Ana Claudia Torrecilhas,Lavinia M D Romera,Rafael Pedro Madeira,Sergio Schenkman,Lucio H Freitas-Junior,Eric Chatelain,Michael A Miles,Carolina B Moraes
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Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-06-26 Yulieth A Upegui Zapata,Fernando Echeverri,Winston Quiñones,Fernando Torres,Montserrat Nacher,Luis I Rivas,Camila Dos Santos Meira,Lashitew Gedamu,Gustavo Escobar,Rosendo Archbold,Iván D Vélez,Sara M Robledo
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Repurposing the open access malaria box reveals compounds with activity against Tritrichomonas foetus trophozoites. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-06-17 Katy A Martin,Jeba R J Jesudoss Chelladurai,Christopher Bader,Elizabeth Carreiro,Katelyn Long,Kylie Thompson,Matthew T Brewer
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In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-06-02 Lenu B Fakae,Carl W Stevenson,Xing-Quan Zhu,Hany M Elsheikha
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Identification of annotated bioactive molecules that impair motility of the blood fluke Schistosoma mansoni. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-06-01 Thomas B Duguet,Anastasia Glebov,Asimah Hussain,Shashank Kulkarni,Igor Mochalkin,Timothy G Geary,Mohammed Rashid,Thomas Spangenberg,Paula Ribeiro
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Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-05-24 Phanankosi Moyo,William Shamburger,Mariëtte E van der Watt,Janette Reader,Ana Carolina C de Sousa,Timothy J Egan,Vinesh J Maharaj,Gerhard Bringmann,Lyn-Marie Birkholtz
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Dicyclanil resistance in the Australian sheep blowfly, Lucilia cuprina, substantially reduces flystrike protection by dicyclanil and cyromazine based products Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-05-11 Narelle Sales; Monica Suann; Kim Koeford
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Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-05-01 Lieselotte Van Bockstal,Dimitri Bulté,Sarah Hendrickx,Jovana Sadlova,Petr Volf,Louis Maes,Guy Caljon
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Cholinergic receptors on intestine cells of Ascaris suum and activation of nAChRs by levamisole. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-04-25 Mark McHugh,Paul Williams,Saurabh Verma,Jo Anne Powell-Coffman,Alan P Robertson,Richard J Martin
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Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1F3P in dogs. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-04-20 Pablo D Jimenez Castro,Abdelmoneim Mansour,Samuel Charles,Joe Hostetler,Terry Settje,Daniel Kulke,Ray M Kaplan
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Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-04-10 Anastasia R Rugel,Meghan A Guzman,Alexander B Taylor,Frédéric D Chevalier,Reid S Tarpley,Stanton F McHardy,Xiaohang Cao,Stephen P Holloway,Timothy J C Anderson,P John Hart,Philip T LoVerde
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MRPA-independent mechanisms of antimony resistance in Leishmania infantum. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-04-02 Noélie Douanne,Victoria Wagner,Gaetan Roy,Philippe Leprohon,Marc Ouellette,Christopher Fernandez-Prada
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Schistosome TRP channels: An appraisal. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-03-24 Swarna Bais,Robert M Greenberg
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An image-based Pathogen Box screen identifies new compounds with anti-Giardia activity and highlights the importance of assay choice in phenotypic drug discovery. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-03-13 Snigdha Tiash,Jake Saunders,Christopher J S Hart,John H Ryan,Andrew G Riches,Tina S Skinner-Adams
Giardia duodenalis, the most prevalent human intestinal parasite causes the disease, giardiasis. On an annual basis G. duodenalis infects ~1 billion people, of which ~280 million develop symptomatic disease. Giardiasis can be severe and chronic, causing malnutrition, stunted growth and poor cognitive development in children. Current treatment options rely on drugs with declining efficacy and side-effects
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Large scale screening for benzimidazole resistance mutations in Nematodirus battus, using both pyrosequence genotyping and deep amplicon sequencing, indicates the early emergence of resistance on UK sheep farms. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-03-06 Lynsey A Melville,Elizabeth Redman,Alison A Morrison,Pai Chia Rebecca Chen,Russell Avramenko,Sian Mitchell,Jan Van Dijk,Giles Innocent,Fiona Sargison,Catriona Aitken,John S Gilleard,Dave J Bartley
Benzimidazoles (BZ) have been the anthelmintic of choice for controlling Nematodirus battus infections since their release in the 1950s. Despite heavy reliance on this single anthelmintic drug class, resistance was not identified in this nematode until 2010 (Mitchell et al., 2011). The study aimed to explore the prevalence of BZ-resistance mutations in N. battus from UK sheep flocks using deep amplicon
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Evaluation of a plant-based food supplement to control flea populations in dogs: A prospective double-blind randomized study. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-02-15 Fabien Moog,Gaetan Vetea Plichart,Jean-Louis Blua,Marie-Christine Cadiergues
A prospective double-blind randomized placebo-controlled study evaluated the tolerance and efficacy of the biological plant-based food supplement Bioticks® (extracts of thyme, rosemary, melissa, fenugreek, absinthe and lemongrass) as a flea-control product. Twelve dogs were used as placebo controls (group A). Ten dogs under similar housing conditions received the same food daily but supplemented with
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Drug resistance in liver flukes. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2020-01-10 I Fairweather,G P Brennan,R E B Hanna,M W Robinson,P J Skuce
Liver flukes include Fasciola hepatica, Fasciola gigantica, Clonorchis sinensis, Opisthorchis spp., Fascioloides magna, Gigantocotyle explanatum and Dicrocoelium spp. The two main species, F. hepatica and F. gigantica, are major parasites of livestock and infections result in huge economic losses. As with C. sinensis, Opisthorchis spp. and Dicrocoelium spp., they affect millions of people worldwide
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Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2019-11-11 Ander Burgaña,Rosa Abellana,Stanislav Zlatanov Yordanov,Rabee Kazan,A Mauricio Pérez Ortiz,Cristina Castillo Ramos,Christian Garavito Hernández,Miriam Molina Rivero,Alessandra Queiroga Gonçalves,Emma Padilla,Josefa Pérez,Roger García-Puig,Tomas M Perez-Porcuna
Dientamoeba fragilis is a trichomonad parasite of the human intestine that is found worldwide. However, the biological cycle and transmission of this parasite have yet to be elucidated. Although its pathogenic capacity has been questioned, there is increasing evidence that clinical manifestations vary greatly. Different therapeutic options with antiparasitic drugs are currently available; however,
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Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2019-10-22 Monica M Kangussu-Marcolino,Gretchen M Ehrenkaufer,Emily Chen,Anjan Debnath,Upinder Singh
The free-living amebae Naegleria, Acanthamoeba, and Balamuthia cause rare but life-threatening infections. All three parasites can cause meningoencephalitis. Acanthamoeba can also cause chronic keratitis and both Balamuthia and Acanthamoeba can cause skin and systemic infections. There are minimal drug development pipelines for these pathogens despite a lack of available treatment regimens and high
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Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2019-10-22 Yolanda Pérez-Pertejo,José M Escudero-Martínez,Rosa M Reguera,Rafael Balaña-Fouce,Pablo A García,Pablo G Jambrina,Arturo San Feliciano,María-Ángeles Castro
Leishmania is the aethiological agent responsible for the visceral leishmaniasis, a serious parasite-borne disease widely spread all over the World. The emergence of resistant strains makes classical treatments less effective; therefore, new and better drugs are necessary. Naphthoquinones are interesting compounds for which many pharmacological properties have been described, including leishmanicidal
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Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2019-10-06 Frank Turnbull,Eileen Devaney,Alison A Morrison,Roz Laing,Dave J Bartley
Recent reports of monepantel (MPTL) resistance in UK field isolates of Teladorsagia circumcincta has highlighted the need for a better understanding of the mechanism of MPTL-resistance in order to preserve its anthelmintic efficacy in this economically important species. Nine discrete populations of T. circumcincta were genotypically characterised; three MPTL-susceptible isolates, three experimentally
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Profiles of Kelch mutations in Plasmodium falciparum across South Asia and their implications for tracking drug resistance. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2019-10-04 Jyoti Chhibber-Goel,Amit Sharma
Artemisinin-based combination therapy (ACT) offers highly successful treatment of malaria. Emergence and spread of Plasmodium falciparum (Pf) parasites with decreased susceptibility to ACT in South-East Asia has caused concern worldwide. The current accepted criteria to assess artemisinin (ART) resistance relies upon data on treatment failure, delayed parasite clearance at day 3 (DPC3), parasite clearance
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Development of a topical liposomal formulation of Amphotericin B for the treatment of cutaneous leishmaniasis. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2019-09-23 Mahmoud Reza Jaafari,Mahdi Hatamipour,Seyedeh Hoda Alavizadeh,Azam Abbasi,Zahra Saberi,Sima Rafati,Yasaman Taslimi,Akram Miramin Mohammadi,Ali Khamesipour
BACKGROUND Currently, there is no topical treatment available for any form of cutaneous leishmaniasis (CL) in most of the endemic areas. The aim of the current study was to develop a topical nano-liposomal Amphotericin B (AmB) for the treatment of CL. METHODOLOGY/PRINCIPAL FINDINGS Liposomes containing 0.1, 0.2 and 0.4% AmB (Lip-AmB) were formulated and characterized for the size, entrapment efficiency
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Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2019-09-20 Camino Gutiérrez-Corbo,Raquel Álvarez-Velilla,Rosa M Reguera,Carlos García-Estrada,Mark Cushman,Rafael Balaña-Fouce,Yolanda Pérez-Pertejo
DNA topoisomerases are considered consolidated druggable targets against diseases produced by trypanosomatids. Several reports indicated that indenoisoquinolines, a family of non-camptothecinic based topoisomerase poisons, have a strong leishmanicidal effect both in vitro and in vivo in murine models of visceral leishmaniasis. The antileishmanial effect of the indenoisoquinolines implies several mechanisms
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Anti-schistosomal action of the calcium channel agonist FPL-64176. Int. J. Parasitol. Drugs Drug Resist. (IF 3.009) Pub Date : 2019-09-14 Paul McCusker,John D Chan
Subversion of parasite neuromuscular function is a key strategy for anthelmintic drug development. Schistosome Ca2+ signaling has been an area of particular interest for decades, with a specific focus on L-type voltage-gated Ca2+ channels (Cavs). However, the study of these channels has been technically challenging. One barrier is the lack of pharmacological probes that are active on flatworms, since