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The acute effect of a β-glucan-enriched oat bread on gastric emptying, GLP-1 response, and postprandial glycaemia and insulinemia: a randomised crossover trial in healthy adults Nutr. Metab. (IF 4.5) Pub Date : 2024-03-18 Ingrid Revheim, Simon Ballance, Adelheid Fretland Standal, Anne Rieder, Jutta Dierkes, Anette E. Buyken, Odd Helge Gilja, Trygve Hausken, Hanne Rosendahl-Riise
The cereal fibre β-glucan reduces postprandial glycaemia, however, the underlying mechanisms are not fully understood. Thus, the aim of this study was to investigate the acute effect of a β-glucan-enriched oat bread on gastric emptying half-time (T1/2), gastric emptying lag phase (Tlag), and gastric emptying rate (GER), and the secretion of glucagon-like peptide-1 (GLP-1) as potential means to influence
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Glutamine prevents high-fat diet-induced hepatic lipid accumulation in mice by modulating lipolysis and oxidative stress Nutr. Metab. (IF 4.5) Pub Date : 2024-03-08 Yongjie Zhang, Yangli Wang, Xin Liao, Tong Liu, Fengyuan Yang, Kaiqiang Yang, Zhuohua Zhou, Yinxu Fu, Ting Fu, Aliaksei Sysa, Xiandan Chen, Yao Shen, Jianxin Lyu, Qiongya Zhao
Metabolic-associated fatty liver disease (MAFLD) is related to metabolic dysfunction and is characterized by excess fat storage in the liver. Several studies have indicated that glutamine could be closely associated with lipid metabolism disturbances because of its important role in intermediary metabolism. However, the effect of glutamine supplementation on MAFLD progression remains unclear. Here
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Enhancing cardiometabolic health: unveiling the synergistic effects of high-intensity interval training with spirulina supplementation on selected adipokines, insulin resistance, and anthropometric indices in obese males Nutr. Metab. (IF 4.5) Pub Date : 2024-03-07 Maryam Delfan, Ayoub Saeidi, Rashmi Supriya, Kurt A Escobar, Ismail Laher, Katie M. Heinrich, Katja Weiss, Beat Knechtle, Hassane Zouhal
This study investigated the combined effects of 12 weeks of high-intensity interval training (HIIT) and spirulina supplementation on adipokine levels, insulin resistance, anthropometric indices, and cardiorespiratory fitness in 44 obese males (aged 25–40 years). The participants were randomly assigned to one of four groups: control (CG), supplement (SG), training (TG), or training plus supplement (TSG)
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The difference between 2-hour post-challenge and fasting plasma glucose associates with the risk of cardiovascular disease in a normoglycemic population: the Tehran lipid and glucose study Nutr. Metab. (IF 4.5) Pub Date : 2024-02-22 Amir Abdi, Karim Kohansal, Davood Khalili, Fereidoun Azizi, Farzad Hadaegh
Elevated fasting plasma glucose (FPG) and 2-hour post-challenge glucose (2hPG) levels are known to be independent risk factors for cardiovascular disease (CVD). However, there is limited data on the association of the difference between these measures and the risk of CVD. This study aims to investigate this association in normoglycemic Iranian adults, particularly in those with low-normal FPG levels
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Effects of a dietary intervention with lacto-ovo-vegetarian and Mediterranean diets on apolipoproteins and inflammatory cytokines: results from the CARDIVEG study Nutr. Metab. (IF 4.5) Pub Date : 2024-02-01 Giuditta Pagliai, Marta Tristan Asensi, Monica Dinu, Francesca Cesari, Alessia Bertelli, Anna Maria Gori, Betti Giusti, Rossella Marcucci, Francesco Sofi, Barbara Colombini
Apolipoproteins have been recently proposed as novel markers of cardiovascular disease (CVD) risk. However, evidence regarding effects of diet on apolipoproteins is limited. To compare the effects of Mediterranean diet (MD) and lacto-ovo vegetarian diet (VD) on apolipoproteins and traditional CVD risk factors in participants with low-to-moderate CVD risk. Fifty-two participants (39 women; 49.1 ± 12
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Association of gestational metabolic syndrome with the Chinese Healthy Eating Index in mid-pregnancy: a cross-sectional study Nutr. Metab. (IF 4.5) Pub Date : 2024-01-26 Hui Wu, Min-hui Yi, Bing-gang Liu, Yan Xu, Qin Wu, Yu-hong Liu, Ling-peng Lu
This study aims to investigate the relationship between gestational metabolic syndrome (GMS) and the Chinese Healthy Eating Index (CHEI) in mid-pregnancy, and to identify potentially beneficial or high-risk dietary habits. We have developed a mid-pregnancy version of CHEI-2022, adapting the Chinese Healthy Eating Index to align with the food quantity recommendations outlined in the 2022 Dietary Guidelines
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Oxyresveratrol attenuates bone resorption by inhibiting the mitogen-activated protein kinase pathway in ovariectomized rats Nutr. Metab. (IF 4.5) Pub Date : 2024-01-19 Yea-Jin Lee, Jin-Chul Ahn, Chung-Hun Oh
Bone is continuously produced by osteoblasts and resorbed by osteoclasts to maintain homeostasis. Impaired bone resorption by osteoclasts causes bone diseases such as osteoporosis and arthritis. Most pharmacological treatment of osteoporosis focuses on inhibiting osteoclast differentiation, often to restore osteoclast/osteoclast balance. However, recent osteoporosis treatments have various side effects
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Revisiting the interconnection between lipids and vitamin K metabolism: insights from recent research and potential therapeutic implications: a review Nutr. Metab. (IF 4.5) Pub Date : 2024-01-03 Jing Tan, Ying Li
Vitamin K is a lipophilic vitamin, whose absorption, transportation, and distribution are influenced by lipids. The plasma vitamin K level after supplementation is predominantly a lipid-driven effect and independent of existing vitamin K status. However, previous studies examining the efficacy of vitamin K supplementation often overlooked the influence of lipid levels on vitamin K absorption, resulting
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D-mannose promotes the degradation of IDH2 through upregulation of RNF185 and suppresses breast cancer Nutr. Metab. (IF 4.5) Pub Date : 2024-01-02 Ruonan Zhang, Ziyin Tian, Yanping Xu, Lei Lv
D-mannose, an epimer of glucose, which is abundant in some fruits, such as cranberry, has been previously reported to inhibit urinary tract infection. In recent years, the potential function of D-mannose has been broadened into the regulation of other inflammation diseases and cancer. It was reported that D-mannose can increase reactive oxygen species (ROS) production, while IDH2 is important for the
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Dysregulation of mitochondrial dynamics mediated aortic perivascular adipose tissue-associated vascular reactivity impairment under excessive fructose intake Nutr. Metab. (IF 4.5) Pub Date : 2024-01-02 Kay L. H. Wu, Chih-Wei Wu, Lee-Wei Chen, Hsiao-Huang Chang, Ching-Li Cheng, Cai-Yi Wu, Yu-Chi Lee, I-Chun Chen, Chun-Ying Hung, Wen-Chung Liu
Excessive fructose intake presents the major risk factor for metabolic cardiovascular disease. Perivascular adipose tissue (PVAT) is a metabolic tissue and possesses a paracrine function in regulating aortic reactivity. However, whether and how PVAT alters vascular function under fructose overconsumption remains largely unknown. In this study, male Sprague-Dawley rats (8 weeks old) were fed a 60% high
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Effect of probiotic supplementation on lipoprotein-associated phospholipase A2 in type 2 diabetic patients: a randomized double blind clinical controlled trial Nutr. Metab. (IF 4.5) Pub Date : 2024-01-02 Salman Jaff, Mohammed Gubari, Sakineh Shab-Bidar, Kurosh Djafarian
It has been recently reported that lipoprotein-associated phospholipase A2 (Lp-PLA2) may predict the risk of cardiovascular disease. The effect of multi-strain probiotics on Lp-PLA2 in patients with type 2 diabetes is still not clear. This study aimed to determine the effect of multi-strain probiotic supplementation on lipoprotein-associated phospholipase A2, and glycemic status, lipid profile, and
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Deficiency of Trex1 leads to spontaneous development of type 1 diabetes Nutr. Metab. (IF 4.5) Pub Date : 2024-01-02 Jiang-Man Zhao, Zhi-Hui Su, Qiu-Ying Han, Miao Wang, Xin Liu, Jing Li, Shao-Yi Huang, Jing Chen, Xiao-Wei Li, Xia-Ying Chen, Zeng-Lin Guo, Shuai Jiang, Jie Pan, Tao Li, Wen Xue, Tao Zhou
Type 1 diabetes is believed to be an autoimmune condition, characterized by destruction of insulin-producing cells, due to the detrimental inflammation in pancreas. Growing evidences have indicated the important role of type I interferon in the development of type 1 diabetes. Trex1-deficient rats were generated by using CRISPR-Cas9. The fasting blood glucose level of rat was measured by a Roche Accuchek
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Effects of riboflavin deficiency and high dietary fat on hepatic lipid accumulation: a synergetic action in the development of non-alcoholic fatty liver disease Nutr. Metab. (IF 4.5) Pub Date : 2024-01-02 Yanxian Wang, Xiangyu Bian, Min Wan, Weiyun Dong, Weina Gao, Zhanxin Yao, Changjiang Guo
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Riboflavin, one of water soluble vitamins, plays a role in lipid metabolism and antioxidant function. However, the effects of riboflavin deficiency on NAFLD development have not yet to be fully explored. In the present study, an animal model of NAFLD was induced by high fat diet feeding in mice
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Amelioration of Atherosclerosis by lycopene is linked to the modulation of gut microbiota dysbiosis and related gut-heart axis activation in high-fat diet-fed ApoE−/− mice Nutr. Metab. (IF 4.5) Pub Date : 2023-12-01 Tengcan Tu, Hao Liu, Zhenhao Liu, Yunyi Liang, Chujun Tan, Dan Feng, Jun Zou
Interplay between gut microbiota and heart, termed “gut-heart” axis, has a crucial role in the pathogenesis of atherosclerosis. Our previous study showed that lycopene possesses anti-inflammatory and anti-atherosclerotic effects, but its link to the gut microbiota is poorly understood. Herein, we surmised that lycopene could regulate the gut microbiota, exert anti-atherosclerotic effect by regulating
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Correction: The association between dietary quality scores with C-reactive protein and novel biomarkers of inflammation platelet-activating factor and lipoprotein-associated phospholipase A2: a cross-sectional study Nutr. Metab. (IF 4.5) Pub Date : 2023-11-27 Carolyn J. English, Anna E. Lohning, Hannah L. Mayr, Mark Jones, Helen MacLaughlin, Dianne P. Reidlinger
Correction: Nutrition & Metabolism (2023) 20:38 https://doi.org/10.1186/s12986-023-00756-x Following the publication of the original article [1], the authors identified errors in the description of the score range of the Vegetarian Lifestyle Index in Table 1 and in the Methods section. The updated sentence and Table 1 are given below, and the changes have been highlighted in bold typeface. The sentence
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Exploring the underlying mechanisms of fisetin in the treatment of hepatic insulin resistance via network pharmacology and in vitro validation Nutr. Metab. (IF 4.5) Pub Date : 2023-11-23 Tian Li, Junjun Ling, Xingrong Du, Siyu Zhang, Yan Yang, Liang Zhang
To characterize potential mechanisms of fisetin on hepatic insulin resistance (IR) using network pharmacology and in vitro validation. Putative targets of fisetin were retrieved from the Traditional Chinese Medicine Systems Pharmacology database, whereas the potential genes of hepatic IR were obtained from GeneCards database. A protein–protein interaction (PPI) network was constructed according to
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Intrauterine growth restriction alters kidney metabolism at the end of nephrogenesis Nutr. Metab. (IF 4.5) Pub Date : 2023-11-21 Sheng-Yuan Ho, Merryl Esther Yuliana, Hsiu-Chu Chou, Chung-Ming Chen
This study investigated the effect of uteroplacental insufficiency (UPI) on renal development by detecting metabolic alterations in the kidneys of rats with intrauterine growth restriction (IUGR). On gestational day 17, pregnant Sprague Dawley rats were selected and allocated randomly to either the IUGR group or the control group. The IUGR group received a protocol involving the closure of bilateral
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A comparative study on indicators of vitamin A status and risk factors for sensitivity and specificity of the methods to detect vitamin A deficiency Nutr. Metab. (IF 4.5) Pub Date : 2023-11-16 Olivier O. Sombié, Augustin N. Zeba, Jérome W. Somé, Adama Kazienga, Michael Grahn, Sherry A. Tanumihardjo, Stefaan De Henauw, Souheila Abbeddou
Serum retinol (SR) and retinol-binding protein (RBP) are commonly used indicators, but they are affected by infections and inflammation. This study aimed to assess the sensitivity and specificity of VA indicators to detect vitamin A deficiency (VAD) in 36–59-month-old children living in a rural area in Burkina Faso. In a community-based study, two cross-sectional surveys were carried out from November
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Early adulthood weight change, midlife “Life’s essential 8” health status and risk of cardiometabolic diseases: a chinese nationwide cohort study Nutr. Metab. (IF 4.5) Pub Date : 2023-11-01 Qiuyu Cao, Mian Li, Guijun Qin, Li Yan, Jiang He, Min Xu, Yu Xu, Tiange Wang, Yuhong Chen, Shuangyuan Wang, Hong Lin, Zhiyun Zhao, Zhengnan Gao, Tianshu Zeng, Ruying Hu, Xuefeng Yu, Gang Chen, Qing Su, Yiming Mu, Lulu Chen, Xulei Tang, Qin Wan, Guixia Wang, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong
The association between weight change during early adulthood and cardiometabolic diseases remains uncertain in Chinese population. Whether the association varies with comprehensive cardiovascular health (CVH) in midlife assessed by “Life’s Essential 8” has not been characterized. We aim to examine the associations of early adulthood weight change and midlife “Life’s Essential 8” CVH status with cardiometabolic
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Healthy lifestyle scores associate with incidence of type 2 diabetes mediated by uric acid Nutr. Metab. (IF 4.5) Pub Date : 2023-11-01 Xinyue He, Wei Shao, Senhai Yu, Jiazhou Yu, Changzhen Huang, Haiqing Ren, Chengguo Liu, Yuying Xu, Yimin Zhu
Whether and to what extent serum uric acid (SUA) mediates the association between combined lifestyle behaviors and type 2 diabetes mellitus (T2DM) remain unclear. This study aimed to investigate the role of SUA in the relationship between healthy lifestyle scores (HLS) and the incidence of T2DM. This prospective study used data from Zhejiang Metabolic Syndrome cohort. A HLS (5-point scale including
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The association of serum betaine concentrations with the risk of new-onset cancers: results from two independent nested case-control studies Nutr. Metab. (IF 4.5) Pub Date : 2023-10-30 Hailun Xie, Kangping Zhang, Yaping Wei, Guotian Ruan, Heyang Zhang, Shuqun Li, Yun Song, Ping Chen, Lishun Liu, Binyan Wang, Hanping Shi
Evidence from epidemiologic studies on the association of circulating betaine levels with the incident risk of cancer has been inconsistent. We aimed to investigate the prospective association of serum betaine concentrations with the risk of cancer. We performed two, nested, case-control studies utilizing data from the “H-type Hypertension Prevention and Control Public Service Project” (HHPCP) and
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Does dietary nitrate boost the effects of caloric restriction on brain health? Potential physiological mechanisms and implications for future research Nutr. Metab. (IF 4.5) Pub Date : 2023-10-25 Mushari Alharbi, Blossom CM Stephan, Oliver M Shannon, Mario Siervo
Dementia is a highly prevalent and costly disease characterised by deterioration of cognitive and physical capacity due to changes in brain function and structure. Given the absence of effective treatment options for dementia, dietary and other lifestyle approaches have been advocated as potential strategies to reduce the burden of this condition. Maintaining an optimal nutritional status is vital
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Differential effects of plant-based flours on metabolic homeostasis and the gut microbiota in high-fat fed rats Nutr. Metab. (IF 4.5) Pub Date : 2023-10-19 Taylor M. Martinez, Hallie R. Wachsmuth, Rachel K. Meyer, Savanna N. Weninger, Adelina I. Lane, Archana Kangath, Gabriele Schiro, Daniel Laubitz, Jennifer H. Stern, Frank A. Duca
The gut microbiome is a salient contributor to the development of obesity, and diet is the greatest modifier of the gut microbiome, which highlights the need to better understand how specific diets alter the gut microbiota to impact metabolic disease. Increased dietary fiber intake shifts the gut microbiome and improves energy and glucose homeostasis. Dietary fibers are found in various plant-based
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The effect of the modified fat-protein unit algorithm compared with that of carbohydrate counting on postprandial glucose in adults with type-1 diabetes when consuming meals with differing macronutrient compositions: a randomized crossover trial Nutr. Metab. (IF 4.5) Pub Date : 2023-10-16 Yunying Cai, Mengge Li, Lun Zhang, Jie Zhang, Heng Su
The optimization of glucose control in type-1 diabetes is challenged by postprandial glycemic variability. This study aimed to compare the postprandial glycemic effects of carbohydrate counting and the modified fat-protein unit (FPU) algorithms following meals with different protein and fat emphases in adults with type-1 diabetes. Thirty adults with type-1 diabetes aged 18 to 45 years participated
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New insights into the nutritional genomics of adult-onset riboflavin-responsive diseases Nutr. Metab. (IF 4.5) Pub Date : 2023-10-16 Chiara Murgia, Ankush Dehlia, Mark A. Guthridge
Riboflavin, or vitamin B2, is an essential nutrient that serves as a precursor to flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). The binding of the FAD and/or FMN cofactors to flavoproteins is critical for regulating their assembly and activity. There are over 90 proteins in the human flavoproteome that regulate a diverse array of biochemical pathways including mitochondrial metabolism
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Prospective association between an obesogenic dietary pattern in early adolescence and metabolomics derived and traditional cardiometabolic risk scores in adolescents and young adults from the ALSPAC cohort Nutr. Metab. (IF 4.5) Pub Date : 2023-09-15 Eduard Martínez Solsona, Laura Johnson, Kate Northstone, Genevieve Buckland
Dietary intake during early life may be a modifying factor for cardiometabolic risk (CMR). Metabolomic profiling may enable more precise identification of CMR in adolescence than traditional CMR scores. We aim to assess and compare the prospective associations between an obesogenic dietary pattern (DP) score at age 13 years with a novel vs. traditional CMR score in adolescence and young adulthood in
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METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6 Nutr. Metab. (IF 4.5) Pub Date : 2023-09-15 Yongqing Li, Dantong Zhang, Yinan Gao, Peijun Wang, Zejun Wang, Bingyang Zhang, Junjun Liu, Diwen Ye, Wanshan Ma, Sumei Lu
Insulin resistance (IR) in hepatocytes endangers human health, and frequently results in the development of non-alcoholic fatty liver disease (NAFLD). Research on m6A methylation of RNA molecules has gained popularity in recent years; however, the molecular mechanisms regulating the processes of m6A modification and IR are not known. The cytochrome P450 (CYP450) enzyme system, which is mainly found
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Effect of weight change on the association between overall and source of carbohydrate intake and risk of metabolic syndrome: Tehran lipid and glucose study Nutr. Metab. (IF 4.5) Pub Date : 2023-09-12 Somayeh Hosseinpour-Niazi, Bahar Bakhshi, Parvin Mirmiran, Zahra Gaeini, Farzad Hadaegh, Fereidoun Azizi
In this prospective cohort study, we aimed to evaluate the association between dietary carbohydrates, whole grains, refined grains, and simple sugar with the risk of metabolic syndrome (MetS) and assess the effect of weight change on these associations. This study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS). We included 1915 healthy participants with complete demographic
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The association between dietary quality scores with C-reactive protein and novel biomarkers of inflammation platelet-activating factor and lipoprotein-associated phospholipase A2: a cross-sectional study Nutr. Metab. (IF 4.5) Pub Date : 2023-09-12 Carolyn J. English, Anna E. Lohning, Hannah L. Mayr, Mark Jones, Helen MacLaughlin, Dianne P. Reidlinger
Healthy dietary patterns are associated with lower inflammation and cardiovascular disease (CVD) risk and adherence can be measured using diet quality scores. Inflammation is traditionally measured with C-reactive protein (hsCRP), however there is interest in novel pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A2 (Lp-PLA2) that are specifically involved
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The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study Nutr. Metab. (IF 4.5) Pub Date : 2023-09-04 Sophie Callanan, Sarah Louise Killeen, Anna Delahunt, Nessa Cooney, Rosemary Cushion, Malachi J. McKenna, Rachel K. Crowley, Patrick J. Twomey, Mark T. Kilbane, Ciara M. McDonnell, Catherine M. Phillips, Declan Cody, Fionnuala M. McAuliffe
Macrosomia (birthweight ≥ 4 kg or ≥ 4.5 kg) is strongly associated with a predisposition to childhood obesity, which in turn is linked with adverse cardiometabolic health. Despite this, there is a lack of longitudinal investigation on the impact of high birthweight on cardiometabolic outcomes in youth. The preteen period represents an important window of opportunity to further explore this link, to
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Associations of starchy and non-starchy vegetables with risk of metabolic syndrome: evidence from the NHANES 1999–2018 Nutr. Metab. (IF 4.5) Pub Date : 2023-08-31 Yingrui Li, Bingquan Xiong, Min Zhu, Yuqian Ren, Yi Lan, Tianyang Hu, Yufan Wang, Huiping Yang, Zhiyin Liao, Kaihu Xiao, Qiang She
Higher dietary quality, including increased vegetable consumption, was associated with a reduced risk of metabolic syndrome (MetS). However, specific vegetable consumption in the development of MetS remains obscure. Our study aimed to investigate the correlation between starchy and non-starchy vegetables and MetS. Secondary data analysis from the National Health and Nutrition Examination Survey (NHANES
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The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: a comprehensive review of putative molecular mechanisms Nutr. Metab. (IF 4.5) Pub Date : 2023-08-29 Husna Dharma Putera, Rumi Iqbal Doewes, Mohammed Nader Shalaby, Andrés Alexis Ramírez-Coronel, Zachary S. Clayton, Walid Kamal Abdelbasset, Saidmurodkhon S. Murtazaev, Abduladheem Turki Jalil, Pegah Rahimi, Elyas Nattagh-Eshtivani, Mahsa Malekahmadi, Naseh Pahlavani
Conjugated linoleic acids (CLAs) are polyunsaturated fatty acids primarily found in dairy products and ruminant animal products such as beef, lamb, and butter. Supplementation of CLAs has recently become popular among athletes due to the variety of health-promoting effects, including improvements in physical performance. Preclinical and some clinical studies have shown that CLAs can reduce inflammation
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Human nutritional relevance and suggested nutritional guidelines for vitamin A5/X and provitamin A5/X Nutr. Metab. (IF 4.5) Pub Date : 2023-08-15 Torsten Bohn, Julian Hellman-Regen, Angel R. de Lera, Volker Böhm, Ralph Rühl
In the last century, vitamin A was identified that included the nutritional relevant vitamin A1 / provitamin A1, as well as the vitamin A2 pathway concept. Globally, nutritional guidelines have focused on vitamin A1 with simplified recommendations and calculations based solely on vitamin A. The vitamin A / provitamin A terminology described vitamin A with respect to acting as a precursor of 11-cis-retinal
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Association between dietary supplement use and mortality among US adults with diabetes: a longitudinal cohort study Nutr. Metab. (IF 4.5) Pub Date : 2023-08-11 Rong Hua, Chun Sing Lam, Natural Chu, Aimin Yang, Elaine Chow, Yin Ting Cheung
Despite the popularity of dietary supplements, their effectiveness and safety in patients with diabetes remain controversial. Furthermore, evidence from clinical trials may not be generalizable to real-world settings. This study examined the association between dietary supplement use and mortality outcomes among patients with diabetes based on a nationally representative sample of US adults. This study
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Effect of a 3-month L-carnitine supplementation and resistance training program on circulating markers and bone mineral density in postmenopausal women: a randomized controlled trial Nutr. Metab. (IF 4.5) Pub Date : 2023-08-02 Robert A. Olek, Emilia Samborowska, Piotr Wisniewski, Pawel Wojtkiewicz, Krystian Wochna, Jacek Zielinski
Higher circulating levels of trimethylamine N-oxide (TMAO), which is a metabolite that can be produced by the gut microbiota from L-carnitine (LC), have been associated with bone mineral density (BMD). Because LC supplementation can improve bone density and microstructural properties in animal models, this study aimed to examine the effects of 12 weeks of LC supplementation on BMD and selected blood
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Chorionicity-associated variation in metabolic phenotype of cord blood in twin Nutr. Metab. (IF 4.5) Pub Date : 2023-07-13 Xiaoyu Liu, Jing Yang, Rui Ran, Fei Long, Yang Yang, Xiaojing Dong, Richard Saffery, Boris Novakovic, Hatem Mousa, Yuan Wei, Lina Hu, Ting-Li Han
Monochorionic (MC) twins present a higher incidence of unfavorable clinical perinatal outcomes than dichorionic (DC) twins, often in association with placental vascular anastomosis. In this study, we profiled the umbilical cord plasma metabolomes of uncomplicated MC and DC twin pregnancies and related these to several offspring outcomes, previously associated with birthweight. Umbilical vein blood
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Pharmacotherapies of NAFLD: updated opportunities based on metabolic intervention Nutr. Metab. (IF 4.5) Pub Date : 2023-07-06 Yaodi Shao, Suzhen Chen, Liu Han, Junli Liu
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that is becoming increasingly prevalent, and it ranges from simple steatosis to cirrhosis. However, there is still a lack of pharmacotherapeutic strategies approved by the Food and Drug Administration, which results in a higher risk of death related to carcinoma and cardiovascular complications. Of note, it is well established that
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Perilipin5 protects against non-alcoholic steatohepatitis by increasing 11-Dodecenoic acid and inhibiting the occurrence of ferroptosis Nutr. Metab. (IF 4.5) Pub Date : 2023-06-22 Xinming Xu, Jin Qiu, Xiaoya Li, Juntong Chen, Yue Li, Xinmei Huang, Shufei Zang, Xinran Ma, Jun Liu
Non-alcoholic steatohepatitis (NASH) is a major contributor to liver cirrhosis and hepatocellular carcinoma. There remains no effective pharmacological therapy. The hepatic lipid metabolism and fatty acid β-oxidation are regulated by Perilipin5 (Plin5). However, it is yet unknown how Plin5 affects NASH and the molecular process. High-fat, high-cholesterol and high-fructose (HFHC) diets were used to
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A high-trans fat, high-carbohydrate, high-cholesterol, high-cholate diet-induced nonalcoholic steatohepatitis mouse model and its hepatic immune response Nutr. Metab. (IF 4.5) Pub Date : 2023-05-27 Qian Zhang, Yue Jin, Xin Xin, Ziming An, Yi-yang Hu, Yajuan Li, Qin Feng
Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive disease that can progress to non-alcoholic steatohepatitis (NASH). Animal models are important tools for basic NASH research. Immune activation plays a key role in liver inflammation in patients with NASH. We established a high-trans fat, high-carbohydrate, and high-cholesterol, high-cholate diet-induced (HFHCCC) mouse model. C57BL/6
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Correction: The effects of a low carbohydrate diet combined with partial meal replacement on obese individuals Nutr. Metab. (IF 4.5) Pub Date : 2023-05-10 Yulian Zhong, Ximin Chen, Chao Huang, Yuexiao Chen, Fengyi Zhao, Runhua Hao, Niannian Wang, Wang Liao, Hui Xia, Ligang Yang, Shaokang Wang, Guiju Sun
Following publication of the original article [1], the authors identified an error in Table 1. The correct table is given below. Table 1 Groups and interventionsFull size table The original article [1] has been corrected. Zhong Y, et al. The effects of a low carbohydrate diet combined with partial meal replacement on obese individuals. Nutr Metab. 2023;20:18. https://doi.org/10.1186/s12986-023-00740-5
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Serum cholinesterase is associated with incident diabetic retinopathy: the Shanghai Nicheng cohort study Nutr. Metab. (IF 4.5) Pub Date : 2023-05-03 Rong Yu, Xiaoqi Ye, Xiangning Wang, Qiang Wu, Lili Jia, Keqing Dong, Zhijun Zhu, Yuqian Bao, Xuhong Hou, Weiping Jia
Serum cholinesterase (ChE) is positively associated with incident diabetes and dyslipidemia. We aimed to investigate the relationship between ChE and the incidence of diabetic retinopathy (DR). Based on a community-based cohort study followed for 4.6 years, 1133 participants aged 55–70 years with diabetes were analyzed. Fundus photographs were taken for each eye at both baseline and follow-up investigations
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Snack consumption patterns and their associations with risk of incident metabolic syndrome: Tehran lipid and glucose study Nutr. Metab. (IF 4.5) Pub Date : 2023-04-26 Zahra Gaeini, Hanieh Malmir, Parvin Mirmiran, Zahra Feizy, Fereidoun Azizi
Few studies considered the association between snack patterns and metabolic abnormalities. Here we aimed to characterize the major snack patterns among Iranian adults and determine their association with the risk of metabolic syndrome (MetS). This study was conducted on 1713 MetS-free adults who participated in the third phase of the Tehran Lipid and Glucose Study (TLGS). At baseline, dietary intake
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Application of deep learning to predict the low serum albumin in new hemodialysis patients Nutr. Metab. (IF 4.5) Pub Date : 2023-04-24 Cheng-Hong Yang, Yin-Syuan Chen, Jin-Bor Chen, Hsiu-Chen Huang, Li-Yeh Chuang
Serum albumin level is a crucial nutritional indicator for patients on dialysis. Approximately one-third of patients on hemodialysis (HD) have protein malnutrition. Therefore, the serum albumin level of patients on HD is strongly correlated with mortality. In study, the data sets were obtained from the longitudinal electronic health records of the largest HD center in Taiwan from July 2011 to December
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Exploring the association of physical activity with the plasma and urine metabolome in adolescents and young adults Nutr. Metab. (IF 4.5) Pub Date : 2023-04-05 Samuel Muli, Christian Brachem, Ute Alexy, Matthias Schmid, Kolade Oluwagbemigun, Ute Nöthlings
Regular physical activity elicits many health benefits. However, the underlying molecular mechanisms through which physical activity influences overall health are less understood. Untargeted metabolomics enables system-wide mapping of molecular perturbations which may lend insights into physiological responses to regular physical activity. In this study, we investigated the associations of habitual
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Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota Nutr. Metab. (IF 4.5) Pub Date : 2023-04-04 Xuesong Wang, Dongsong Liu, Dan Li, Jiai Yan, Ju Yang, Xiaohui Zhong, Qin Xu, Yuanze Xu, Yanping Xia, Qinyue Wang, Hong Cao, Feng Zhang
To investigate the ameliorative effects of glucosamine (GS), chondroitin sulphate (CS) and glucosamine plus chondroitin sulphate (GC) on rheumatoid arthritis (RA) in rats, and to explore the mechanism of GS, CS and GC in improving RA based on the gut microbiota. RA rat models were effectively developed 14 days after CFA injection, and then garaged with GS, CS and GC. Body weight and paw volume of rats
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The association of long-term calcium and dairy products intake in adolescence with carotid intima media thickness and metabolic syndrome in early adulthood: Tehran Lipid and Glucose Study Nutr. Metab. (IF 4.5) Pub Date : 2023-04-03 Assa AkbarySedigh, Golaleh Asghari, Maryam Mahdavi, Parvin Mirmiran, Majid Valizadeh, Fereidoun Azizi
Calcium could impact on vascular functions and structures and cause atherosclerosis. Thus, we aimed to examine the association of long-term calcium and dairy products intake in adolescence with cIMT and MetS in early adulthood. We considered 217 adolescents aged 12–18 years in the frame work of the Tehran Lipid and Glucose Study (2006–2009) and follow-up them to early adulthood (2015–2017). The valid
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Association between metabolically healthy overweight/obesity and gallstones in Chinese adults Nutr. Metab. (IF 4.5) Pub Date : 2023-03-31 Junlu Zhang, Liangli Chen, Keqing Shen, Jia Zhang, Yue Zhu, Qiaohua Qiao, Liying Chen
Metabolic syndrome and obesity are risk factors for gallstones. However, these two factors often occur together, and few studies have focused on the association between metabolically healthy overweight/obesity (MHOW/MHO) and gallstones. We hypothesized that MHO individuals would be associated with the prevalence of gallstones. This cross-sectional study included 125,668 participants aged 18–80 years
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High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes Nutr. Metab. (IF 4.5) Pub Date : 2023-03-31 Krisztina Németh, Blanka Tóth, Farkas Sarnyai, Anna Koncz, Dorina Lenzinger, Éva Kereszturi, Tamás Visnovitz, Brachyahu Meir Kestecher, Xabier Osteikoetxea, Miklós Csala, Edit I. Buzás, Viola Tamási
High fat diet (HFD) increases the likelihood of dyslipidemia, which can be a serious risk factor for atherosclerosis, diabetes or hepatosteatosis. Although changes in different blood lipid levels were broadly investigated, such alterations in the liver tissue have not been studied before. The aim of the current study was to investigate the effect of HFD on hepatic triglyceride (TG), diglyceride (DG)
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The effects of a low carbohydrate diet combined with partial meal replacement on obese individuals Nutr. Metab. (IF 4.5) Pub Date : 2023-03-30 Yulian Zhong, Ximin Chen, Chao Huang, Yuexiao Chen, Fengyi Zhao, Runhua Hao, Niannian Wang, Wang Liao, Hui Xia, Ligang Yang, Shaokang Wang, Guiju Sun
We explored the dietary effects of replacing normal dietary staple foods with supplementary nutritional protein powder, dietary fiber, and fish oil on several metabolic parameters. We examined weight loss, glucose and lipid metabolism, and intestinal flora in obese individuals when compared with individuals on a reduced staple food low carbohydrate diet. From inclusion and exclusion criteria, 99 participants
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Untargeted metabolomic analysis of ischemic injury in human umbilical vein endothelial cells reveals the involvement of arginine metabolism Nutr. Metab. (IF 4.5) Pub Date : 2023-03-30 Ruihao Wu, Jiayin Zhong, Lei Song, Min Zhang, Lulu Chen, Li Zhang, Zhaohui Qiu
In this study, differentially expressed metabolites of vascular endothelial cells were examined to further understand the metabolic regulation of ischemic injury by untargeted metabolomics. Human umbilical vein endothelial cells (HUVECs) were selected to construct an ischemia model using oxygen–glucose deprivation (OGD) and 0, 3, 6, and 9 h of treatment. After that, cell survival levels were determined
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Effect of different doses of Lacticaseibacillus paracasei K56 on body fat and metabolic parameters in adult individuals with obesity: a pilot study Nutr. Metab. (IF 4.5) Pub Date : 2023-03-21 Guzailinuer Kadeer, Wanrui Fu, Yaqi He, Ying Feng, Wei-Hsein Liu, Wei-Lian Hung, Haotian Feng, Wen Zhao
Studies have shown that probiotics have an effect on reducing body fat on a strain-specific and dose–response bases. The purpose of this study was to evaluate the effect of a novel probiotic strain Lacticaseibacillus paracasei K56 on body fat and metabolic biomarkers in adult individuals with obesity. 74 adult subjects with obesity (body mass index ≥ 30 kg/m2, or percent body fat > 25% for men, percent
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Risk of subclinical atherosclerosis across metabolic transition in individuals with or without fatty liver disease: a prospective cohort study Nutr. Metab. (IF 4.5) Pub Date : 2023-03-10 Zhuojun Xin, Jiaojiao Huang, Qiuyu Cao, Jialu Wang, Ruixin He, Tianzhichao Hou, Yi Ding, Jieli Lu, Tiange Wang, Zhiyun Zhao, Weiqing Wang, Guang Ning, Min Xu, Yufang Bi, Yu Xu, Mian Li
Metabolic dysfunction is a major determinant in the progression of fatty liver disease. It is pivotal to evaluate the metabolic status and subsequent transition in fatty liver population and to identify the risk of subclinical atherosclerosis. The prospective cohort study included 6260 Chinese community residents during 2010–2015. Fatty liver was determined as hepatic steatosis (HS) by ultrasonography
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Different associations of general and abdominal obesity with upper and lower extremity artery disease among a community population in China Nutr. Metab. (IF 4.5) Pub Date : 2023-03-09 Yong Wang, Xiaoyan Guo, Yi Zhang, Ruiyan Zhang, Jue Li
The associations between obesity and abnormalities of upper and lower extremity arteries remain to be elucidated. This study is aimed to investigate whether general obesity and abdominal obesity are associated with upper and lower extremity artery diseases in a Chinese community population. This cross-sectional study included 13,144 participants in a Chinese community population. The associations between
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Weight cycling based on altered immune microenvironment as a result of metaflammation Nutr. Metab. (IF 4.5) Pub Date : 2023-02-22 Wanyang Li, Wei Chen
As a result of the obesity epidemic, more people are concerned about losing weight; however, weight regain is common, leading to repeated weight loss and weight cycling. The health benefits of early weight loss are nullified by weight regain after weight cycling, which has much more severe metabolic consequences. Weight cycling alters body composition, resulting in faster fat recovery and slower muscle
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Lipidomic analysis of brain and hippocampus from mice fed with high-fat diet and treated with fecal microbiota transplantation Nutr. Metab. (IF 4.5) Pub Date : 2023-02-15 Jinchen Li, Hongying Huang, Rong Fan, Yinan Hua, Weiwei Ma
Dietary fat intake affects brain composition and function. Different types of dietary fatty acids alter species and abundance of brain lipids in mice. The aim of this study is to explore whether the changes are effective through gut microbiota. In our study, 8-week-old male C57BL/6 mice were randomly divided into 7 groups and fed with high-fat diet (HFD) with different fatty acid compositions, control
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The effect of DASH diet on glycemic response, meta-inflammation and serum LPS in obese patients with NAFLD: a double-blind controlled randomized clinical trial Nutr. Metab. (IF 4.5) Pub Date : 2023-02-14 Farnaz Rooholahzadegan, Sara Arefhosseini, Helda Tutunchi, Taghi Badali, Manuchehr Khoshbaten, Mehrangiz Ebrahimi-Mameghani
As dietary approaches to stop hypertension (DASH) dietary pattern has been shown to be effective in hypertension and obesity, the present study investigated the effects of following DASH diet on glycemic, meta-inflammation, lipopolysaccharides (LPS) and liver function in obese patients with non-alcoholic fatty liver disease (NAFLD). In this double-blind controlled randomized clinical trial, 40 obese
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A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice Nutr. Metab. (IF 4.5) Pub Date : 2023-02-11 Tsutomu Wada, Yuichiro Miyazawa, Misa Ikurumi, Kento Fuse, Akira Okekawa, Yasuhiro Onogi, Shigeru Saito, Hiroshi Tsuneki, Toshiyasu Sasaoka
MC903 is a synthetic derivative of vitamin D3 that has been designed to diminish its impact on calcium metabolism and is clinically used as a transdermal reagent for psoriasis. Animal studies showed that an oral or intraperitoneal vitamin D3 treatment prevented the development of obesity. In contrast, the bioavailability of orally administered vitamin D3 is reported to be low in obese patients. In
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Gastrodin ameliorates atherosclerosis by inhibiting foam cells formation and inflammation through down-regulating NF-κB pathway Nutr. Metab. (IF 4.5) Pub Date : 2023-02-09 Xiaofei Xue, Fulei Li, Mengke Xu, Bowen Chen, Yanyan Zhao, Mengyu Wang, Ling Li
Gastrodin is an effective polyphenol extracted from Chinese natural herbal Gastrodiae elata Blume, which exhibits antioxidant and anti-inflammatory effects. It has been reported to benefit neurodegenerative diseases, but the effect of Gastrodin on atherosclerosis and the underlying mechanisms remain elusive. The aim of this study is to investigate the function and mechanism of Gastrodin in atherosclerosis
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Heterogeneous effects of individual high-fat diet compositions on phenotype, metabolic outcome, and hepatic proteome signature in BL/6 male mice Nutr. Metab. (IF 4.5) Pub Date : 2023-02-08 Ruth Janoschek, Marion Handwerk, Eva Hucklenbruch-Rother, Lisa Schmitz, Inga Bae-Gartz, Philipp Kasper, Jan-Wilm Lackmann, Tobias Kretschmer, Christina Vohlen, Andrea Mesaros, Martin Purrio, Alexander Quaas, Jörg Dötsch, Sarah Appel
The multitude of obesogenic diets used in rodent studies can hardly be overviewed. Since standardization is missing and assuming that individual compositions provoke individual effects, the choice of quality, quantity and combination of diet ingredients seems to be crucial for the outcome and interpretation of obesity studies. Therefore, the present study was conducted to compare the individual effects
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Association of plasma lipid metabolism profiles with overall survival for patients with gastric cancer undergoing gastrectomy based on 1H-NMR spectroscopy Nutr. Metab. (IF 4.5) Pub Date : 2023-02-07 Yaopeng Qiu, Zhou Xu, Qingfeng Xie, Renyi Zhang, Luyao Wang, Liying Zhao, Hao Liu
Lipid metabolism dysregulation is a prominent metabolic alteration in various cancers. The study aimed to explore the association of plasma lipid metabolism profiles with overall survival (OS) for gastric cancer (GC) patients who received gastrectomy. GC patients who were treated with gastrectomy and measured with plasma lipid metabolism profiles using proton nuclear magnetic resonance (1H-NMR) spectroscopy