-
Cutaneous melanoma and purinergic modulation by phenolic compounds Purinergic Signal. (IF 3.5) Pub Date : 2024-03-18 Geórgia de Carvalho Braga, João Victor Coiado, Vitória Capelli de Melo, Brenno Bianchoni Loureiro, Margarete Dulce Bagatini
-
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine Purinergic Signal. (IF 3.5) Pub Date : 2024-03-15 Shan-Shan Ye, Jia-Ning Wang, Ya-Fei Zhao, Le-Shu Dai, Ji-Zhou Zhang, Yan-Qin Zuo, Jian-Tao Song
-
The functional role of P2 purinergic receptors in the progression of gastric cancer Purinergic Signal. (IF 3.5) Pub Date : 2024-03-12 Fei-long Zou, Ji-peng Liu, Cheng Zuo, Peng-fei He, Jin-xiong Ye, Wen-jun Zhang
-
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye Purinergic Signal. (IF 3.5) Pub Date : 2024-03-11 Mi-Mi Wan, Zhang-Yitian Fu, Tuo Jin, Zhuo-Yuan Wang, Xin-Yi Sun, Wei-Ping Gao
-
Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration Purinergic Signal. (IF 3.5) Pub Date : 2024-03-09
Abstract The pathophysiology of Parkinson’s disease (PD) is marked by degeneration of dopaminergic neurons in the substantia nigra. With advent of COVID-19, which is closely associated with generalized inflammation and multiple organ dysfunctions, the PD patients may develop severe conditions of disease leading to exacerbated degeneration. This condition is caused by the excessive release of pro-inflammatory
-
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia Purinergic Signal. (IF 3.5) Pub Date : 2024-03-06
Abstract Despite the use of various therapies such as hematopoietic stem cell transplantation and chimeric antigen receptor T cell therapy (CAR-T), the prognosis of patients with acute myeloid leukemia (AML) is still generally poor. However, immunotherapy is currently a hot topic in the treatment of hematological tumors. Extracellular adenosine triphosphate (ATP) can be converted to adenosine diphosphate
-
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells Purinergic Signal. (IF 3.5) Pub Date : 2024-03-04 Seyed Hossein Kiaie, Ali Rajabi Zangi, Mohammad Sheibani, Salar Hemmati, Behzad Baradaran, Hadi Valizadeh
-
P2X7 receptors: a bibliometric review from 2002 to 2023 Purinergic Signal. (IF 3.5) Pub Date : 2024-02-29 Haiting Tang, Wei Wei, Yu Luo, Xiaoqing Lu, Jun Chen, Shenqiao Yang, Fei Wu, Haiyan Zhou, Wenbin Ma, Xin Yang
-
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells Purinergic Signal. (IF 3.5) Pub Date : 2024-02-28 Zhan-Guo Gao, Weiping Chen, Ray R. Gao, Jonathan Li, Dilip K. Tosh, John A. Hanover, Kenneth A. Jacobson
-
Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report Purinergic Signal. (IF 3.5) Pub Date : 2024-02-20 Luke Tattersall, Elena Adinolfi, Luca Antonioli, Ankita Agrawal
PRESTO was established in 2022 and is a concerted effort by leading European experts in the field of P2XRs and extracellular ATP to promote and advance the transition to the clinic of P2XR-targeting therapies. Following the inaugural meeting in Ferrara which set the foundations of the action and generated interest from many groups and institutes, the second meeting covered the preclinical and clinical
-
Regulation of nerve-evoked contractions of the murine vas deferens Purinergic Signal. (IF 3.5) Pub Date : 2024-02-20 Pei Yee Wong, Zhihui Fong, Mark A. Hollywood, Keith D. Thornbury, Gerard P. Sergeant
-
The impact of purine nucleosides on neuroplasticity in the adult brain Purinergic Signal. (IF 3.5) Pub Date : 2024-02-17
Abstract Neuroplasticity refers to the nervous system’s ability to adapt and reorganize its cell structures and neuronal networks in response to internal and external stimuli. In adults, this process involves neurogenesis, synaptogenesis, and synaptic and neurochemical plasticity. Several studies have reported the significant impact of the purinergic system on neuroplasticity modulation. And, there
-
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity Purinergic Signal. (IF 3.5) Pub Date : 2024-02-08 Xuhao Chen, Xiaoting Sun, Yuanyuan Ge, Xuzhao Zhou, Jiang-Fan Chen
-
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain Purinergic Signal. (IF 3.5) Pub Date : 2024-02-02 Mingzhu Huo, Qingxiang Zhang, Yuxin Si, Youlin Zhang, Hongen Chang, Mengmeng Zhou, Di Zhang, Yuxin Fang
-
Molecular insights into P2X signalling cascades in acute kidney injury Purinergic Signal. (IF 3.5) Pub Date : 2024-01-22 Swati Mishra, Vishwadeep Shelke, Neha Dagar, Maciej Lech, Anil Bhanudas Gaikwad
-
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice Purinergic Signal. (IF 3.5) Pub Date : 2023-12-30
Abstract Sepsis is life-threatening condition that can trigger long-term neurological sequelae, including cognitive impairment in survivors. The pathogenesis of the so-called sickness behavior is poorly understood, but sepsis-driven neuroinflammation is thought to play a key role. Microglia are the central nervous system resident immune cells and play major roles in the induction and the control of
-
P2 purinergic receptors regulate the progression of colorectal cancer Purinergic Signal. (IF 3.5) Pub Date : 2023-12-28
Abstract More and more studies have revealed that P2 purinergic receptors play a key role in the progression of colorectal cancer (CRC). P2X and P2Y purinergic receptors can be used as promoters and regulators of CRC and play a dual role in the progression of CRC. CRC microenvironment is rich in ATP and its cleavage products (ADP, AMP, Ado), which act as activators of P2X and P2Y purinergic receptors
-
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina Purinergic Signal. (IF 3.5) Pub Date : 2023-12-27
Abstract In the avian retina, ADP induces the proliferation of late developing glia progenitors. Here, we show that in serum-containing retinal cell cultures, ADP-induced increase in [3H]-thymidine incorporation can be prevented by the IGF-1 receptor antagonists AG1024 and I-OMe-Tyrphostin AG 538, suggesting the participation of IGF-1 in ADP-mediated progenitor proliferation. In contrast, no increase
-
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors Purinergic Signal. (IF 3.5) Pub Date : 2023-11-30 Sophie K. F. De Salis, Jake Zheng Chen, Kristen K. Skarratt, Stephen J. Fuller, Thomas Balle
-
Purinergic signaling in the battlefield of viral infections Purinergic Signal. (IF 3.5) Pub Date : 2023-12-01 Nayara Carvalho-Barbosa, Julianna Dias Zeidler, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva
-
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis Purinergic Signal. (IF 3.5) Pub Date : 2023-11-24 Nancy da Rocha Torres Pavione, João Victor Badaró de Moraes, Isadora Cunha Ribeiro, Raissa Barbosa de Castro, Walmir da Silva, Anna Cláudia Alves de Souza, Victor Hugo Ferraz da Silva, Raphael de Souza Vasconcellos, Gustavo da Costa Bressan, Juliana Lopes Rangel Fietto
-
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing Purinergic Signal. (IF 3.5) Pub Date : 2023-11-20 Zhenglang Zhang, Tingting Wang, Zhenhui Luo, Muhammad Haris Zaib, Mengqin Yi, Hekun Zeng, Peiyang Li, Dan Tang, Alexei Verkhratsky, Hong Nie
-
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1) Purinergic Signal. (IF 3.5) Pub Date : 2023-11-17 Isadora Cunha Ribeiro, João Victor Badaró de Moraes, Christiane Mariotini-Moura, Marcelo Depolo Polêto, Nancy da Rocha Torres Pavione, Raissa Barbosa de Castro, Izabel Luzia Miranda, Suélen Karine Sartori, Kryssia Lohayne Santos Alves, Gustavo Costa Bressan, Raphael de Souza Vasconcellos, José Roberto Meyer-Fernandes, Gaspar Diaz-Muñoz, Juliana Lopes Rangel Fietto
-
Purinergic system in cancer stem cells Purinergic Signal. (IF 3.5) Pub Date : 2023-11-15 J. D. Nuñez-Rios, H. Ulrich, M. Díaz-Muñoz, C. Lameu, F. G. Vázquez-Cuevas
-
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors Purinergic Signal. (IF 3.5) Pub Date : 2023-11-08 Haiyan Li, Ji Aee Kim, Seong-Eun Jo, Huisu Lee, Kwan-Chang Kim, Shinkyu Choi, Suk Hyo Suh
-
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway Purinergic Signal. (IF 3.5) Pub Date : 2023-11-07 Fatma Mounieb, Somaia A Abdel-Sattar, Amany Balah, El-Sayed Akool
-
Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme Purinergic Signal. (IF 3.5) Pub Date : 2023-10-31 Álisson Coldebella da Silva, Juliete Nathali Scholl, Amanda de Fraga Dias, Augusto Ferreira Weber, Fernanda Bueno Morrone, Olga Cruz-López, Ana Conejo-García, Joaquín María Campos, Jean Sévigny, Fabrício Figueiró, Ana Maria Oliveira Battastini
-
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation Purinergic Signal. (IF 3.5) Pub Date : 2023-10-23 Si-ying Qu, Han-zhi Wang, Qun-qi Hu, Yi-qi Ma, Yu-rong Kang, Li-qian Ma, Xiang Li, Lu-hang Chen, Bo-yu Liu, Xiao-mei Shao, Bo-yi Liu, Jun-ying Du, Yi Liang, Hong-li Zhao, Yong-liang Jiang, Jian-qiao Fang, Xiao-fen He
-
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation Purinergic Signal. (IF 3.5) Pub Date : 2023-10-16 Seyed Hossein Kiaie, Zahra Hatami, Mohammad Sadegh Nasr, Pouya Pazooki, Salar Hemmati, Behzad Baradaran, Hadi Valizadeh
-
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden Purinergic Signal. (IF 3.5) Pub Date : 2023-09-30 Juan Carlos Gil-Redondo, María José Queipo, Yaiza Trueba, Celia Llorente-Sáez, Julia Serrano, Felipe Ortega, Rosa Gómez-Villafuertes, Raquel Pérez-Sen, Esmerilda G. Delicado
-
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells Purinergic Signal. (IF 3.5) Pub Date : 2023-09-28 Daiane Manica, Gilnei Bruno da Silva, Jussara de Lima, Joana Cassol, Paula Dallagnol, Rafael Antônio Narzetti, Marcelo Moreno, Margarete Dulce Bagatini
-
Coffee, adenosine, and the liver Purinergic Signal. (IF 3.5) Pub Date : 2023-09-27 Jonathan A. Dranoff
A variety of observational studies have demonstrated that coffee, likely acting through caffeine, improves health outcomes in patients with chronic liver disease. The primary pharmacologic role of caffeine is to act as an inhibitor of adenosine receptors. Because key liver cells express adenosine receptors linked to liver injury, regeneration, and fibrosis, it is plausible that the biological effects
-
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells. Purinergic Signal. (IF 3.5) Pub Date : 2023-09-19 Meng-Juan Sun,Yong Tang,Peter Illes
-
Pharmacological characterization of P2Y receptor subtypes – an update Purinergic Signal. (IF 3.5) Pub Date : 2023-09-12 Ivar von Kügelgen
-
P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission Purinergic Signal. (IF 3.5) Pub Date : 2023-09-15 Nathalia Vitureira, Alberto Rafael, Verónica Abudara
-
Editorial: Small molecules and biologics for future purinergic therapeutics Purinergic Signal. (IF 3.5) Pub Date : 2023-09-07 Kenneth A. Jacobson, Daniela Salvemini
Receptor agonists and antagonists and other modulators of purinergic signalling have potential as novel therapeutics for a broad range of diseases and conditions. This special issue focuses on compounds or approaches that are either in clinical trials or headed in that direction. It is intended to serve as an up-to-date description of selected efforts to discover and develop new small molecular purinergic
-
Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer Purinergic Signal. (IF 3.5) Pub Date : 2023-08-12 Kevin Muñoz Forti, Lucas T. Woods, Kimberly J. Jasmer, Jean M. Camden, Gary A. Weisman
-
The role of pyruvate-induced enhancement of oxygen metabolism in extracellular purinergic signaling in the post-cardiac arrest rat model Purinergic Signal. (IF 3.5) Pub Date : 2023-07-29 Koichiro Shinozaki, Vanessa Wong, Tomoaki Aoki, Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Harshal Nandurkar, Betty Diamond, Simon C. Robson, Lance B. Becker
-
James Saville Wiley (1936–2022): pioneer of purinergic research in Australia and abroad Purinergic Signal. (IF 3.5) Pub Date : 2023-07-17 Ben J. Gu, Stephen J. Fuller, Kristen K. Skarratt, Leanne Stokes, Malcolm J. Wiley, Ronald Sluyter
-
Effect of chronic maternal L-Glu intake during gestation and/or lactation on oxidative stress markers, AMPA Glu1 receptor and adenosine A1 signalling pathway from foetal and neonatal cerebellum Purinergic Signal. (IF 3.5) Pub Date : 2023-07-17 Adrián Tejero, David Agustín León-Navarro, Mairena Martín
-
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report Purinergic Signal. (IF 3.5) Pub Date : 2023-07-15 Luke Tattersall, Ankita Agrawal, Elena Adinolfi, Alison Gartland
-
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes Purinergic Signal. (IF 3.5) Pub Date : 2023-07-15 Jaideep Kesavan, Orla Watters, Laura de Diego-Garcia, Aida Menéndez Méndez, Mariana Alves, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel
-
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke Purinergic Signal. (IF 3.5) Pub Date : 2023-07-13 Daylin Gamiotea-Turro, Chunxia C Cronin, Bruce T Liang, Rajkumar Verma
-
Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors Purinergic Signal. (IF 3.5) Pub Date : 2023-07-10 Anna Vlachodimou, Jara Bouma, Michel De Cleyn, Didier Berthelot, Stefan Pype, Jean-Paul Bosmans, Herman van Vlijmen, Berthold Wroblowski, Laura H. Heitman, Adriaan P. IJzerman
-
ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans Purinergic Signal. (IF 3.5) Pub Date : 2023-07-06 Julius Wissemann, Adrian Heidenreich, Helene Zimmermann, Juliane Engelmann, Jasper Jansen, Dymphie Suchanek, Dirk Westermann, Dennis Wolf, Peter Stachon, Julian Merz
-
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension Purinergic Signal. (IF 3.5) Pub Date : 2023-07-05 Mafalda Bessa-Gonçalves, Bruno Bragança, Eduardo Martins-Dias, Adriana Vinhas, Mariana Certal, Tânia Rodrigues, Fátima Ferreirinha, Maria Adelina Costa, Paulo Correia-de-Sá, Ana Patrícia Fontes-Sousa
-
ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis Purinergic Signal. (IF 3.5) Pub Date : 2023-07-04 Elizandra Braganhol, Guilherme Pamplona Bueno de Andrade, Guilherme Tomasi Santos, Marco Antônio Stefani
Glioblastoma (GB) is the most common primary brain tumor in adults and carries a dismal prognosis, despite the best available treatment. The 2021 WHO Classification of CNS tumors incorporated molecular profiling to better define the characteristics and prognosis of tumor types and subtypes. These recent advances in diagnosis have not yet resulted in breakthrough therapies capable of shifting the treatment
-
Physical exercise as a modulator of the purinergic system in the control of sarcopenia in individuals with chronic kidney disease on hemodialysis Purinergic Signal. (IF 3.5) Pub Date : 2023-06-27 Débora Tavares de Resende e Silva, Matheus Ribeiro Bizuti, Natan Rodrigues de Oliveira, Lucas Zannini Medeiros Lima, Victória Galletti dos Santos Arraes, Ana Carolina Gonçalves Zietz, Carolina Zin, Guilherme Vinício de Sousa Silva, Josiano Guilherme Puhle, Fabiana Brum Haag
-
Editorial: Special issue on purinergic signalling and calcification. Purinergic Signal. (IF 3.5) Pub Date : 2023-06-01 Isabel R Orriss,Timothy R Arnett
-
Adenosine A2A receptor-bearing GABAergic neurons in the lateral septum of the brain: novel mediators of depressive-like behavior. Purinergic Signal. (IF 3.5) Pub Date : 2023-05-31 Ya-Fei Zhao,Peter Illes
-
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons Purinergic Signal. (IF 3.5) Pub Date : 2023-05-29 M. Diez-Zaera, A. Ruiz-Calvo, J. I. Diaz-Hernandez, A. Sebastián-Serrano, P. Aivar, B. Alvarez-Castelao, J. Pintor, M. Diaz-Hernandez, M. T. Miras-Portugal
-
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma Purinergic Signal. (IF 3.5) Pub Date : 2023-05-24 Xiao Yang, Yuanyuan Ji, Lin Mei, Wenwen Jing, Xin Yang, Qianwei Liu
-
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure Purinergic Signal. (IF 3.5) Pub Date : 2023-05-22 Ximeng He, Zhichao Zhou
Heart failure is associated with multiple mechanisms, including sympatho-excitation, and is one of the leading causes of death worldwide. Enhanced carotid body chemoreflex function is strongly related to excessive sympathetic nerve activity and sleep-disordered breathing in heart failure. How to reduce the excitability of the carotid body is still scientifically challenging. Both clinical and experimental
-
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity Purinergic Signal. (IF 3.5) Pub Date : 2023-05-15 Stephanie Franczak, Henning Ulrich, Mariusz Z. Ratajczak
-
Identifiability of enzyme kinetic parameters in substrate competition: a case study of CD39/NTPDase1 Purinergic Signal. (IF 3.5) Pub Date : 2023-05-11 Anna N. McGuinness, Aman Tahir, Nadia R. Sutton, Andrew D. Marquis
-
Fetal bovine serum contains biologically available ATP Purinergic Signal. (IF 3.5) Pub Date : 2023-04-19 Valentina Vultaggio-Poma, Leticia Scussel Bergamin, Simonetta Falzoni, Mario Tarantini, Anna Lisa Giuliani, Dorianna Sandonà, Patrizia Polverino De Laureto, Francesco Di Virgilio
-
The P2X7 receptor in mucosal adaptive immunity Purinergic Signal. (IF 3.5) Pub Date : 2023-04-17 Fabio Grassi, Rebecca Marino
-
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73) Purinergic Signal. (IF 3.5) Pub Date : 2023-04-14 S. A. Sosa-Luis, W. J. Ríos-Ríos, A. Almaraz-Arreortua, M. A. Romero-Tlalolini, S. R. Aguilar-Ruiz, R. Valle-Ríos, C. Sánchez-Torres, H. Torres-Aguilar
-
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages Purinergic Signal. (IF 3.5) Pub Date : 2023-04-14 Kshitija Dhuna, Ray Helliwell, Simone N. De Luca, Sarah J. Spencer, Leanne Stokes
-
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair Purinergic Signal. (IF 3.5) Pub Date : 2023-04-13 Adrián Povo-Retana, Sergio Sánchez-García, Carlota Alvarez-Lucena, Rodrigo Landauro-Vera, Patricia Prieto, Carmen Delgado, Paloma Martín-Sanz, Lisardo Boscá