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Omicron breakthrough infected individuals show enhanced nasal antibody responses and preserved T cell responses against the EG.5.1 and BA.2.86 J. Med. Virol. (IF 12.7) Pub Date : 2024-03-18 Zheng Zhu, Shixiong Li, Junhao Fan, Shihao Shang, Yao Zhang, Qiong Zi, Jihao Zheng, Dongfang Wang, Xiaoli Mou, Kepu Liu, Maoxin Lv, Jianlin Yuan, Zhongfang Wang, Jingyou Yu
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Correction to “Exploring the impact of ursodeoxycholic acid therapy on COVID‐19 in a real‐word setting” J. Med. Virol. (IF 12.7) Pub Date : 2024-03-16
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Diversity of enteroviruses in cerebrospinal fluid specimens collected from hospitalised patients in the private and public sector in South Africa J. Med. Virol. (IF 12.7) Pub Date : 2024-03-16 Megan Janse van Rensburg, Janet Mans, Rendani T. Mafuyeka, Kathy‐Anne Strydom, Marcelle Myburgh, Walda B. van Zyl
Enteroviruses cause a wide range of neurological illnesses such as encephalitis, meningitis, and acute flaccid paralysis. Two types of enteroviruses, echovirus E4 and E9, have recently been detected in South Africa and are known to be associated with meningitis and encephalitis. The objective of this study was to characterize enterovirus strains detected in cerebrospinal fluid specimens of hospitalized
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Prolonged viral shedding in an immunocompromised Korean patient infected with hMPXV, sub‐lineage B.1.3, with acquired drug resistant mutations during tecovirimat treatment J. Med. Virol. (IF 12.7) Pub Date : 2024-03-16 Minji Lee, Chi‐Hwan Choi, Jin‐Won Kim, Gyuri Sim, Sang Eun Lee, Hwachul Shin, Jeong hyun Lee, Myung‐Min Choi, Hwajung Yi, Yoon‐Seok Chung
Following the worldwide surge in mpox (monkeypox) in 2022, cases have persisted in Asia, including South Korea, and sexual contact is presumed as the predominant mode of transmission, with a discernible surge in prevalence among immunocompromised patients. Drugs such as tecovirimat can result in drug‐resistant mutations, presenting obstacles to treatment. This study aimed to ascertain the presence
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Design and synthesis of APN and 3CLpro dual-target inhibitors based on STSBPT with anticoronavirus activity J. Med. Virol. (IF 12.7) Pub Date : 2024-03-14 Youle Zheng, Jin Feng, Yanbin Song, Yixin Yu, Min Ling, Mengjia Zhang, Haijiao Xie, Wentao Li, Xu Wang
Coronaviruses (CoVs) have continuously posed a threat to human and animal health. However, existing antiviral drugs are still insufficient in overcoming the challenges caused by multiple strains of CoVs. And methods for developing multi-target drugs are limited in terms of exploring drug targets with similar functions or structures. In this study, four rounds of structural design and modification on
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DENV‐1 genotype V circulation during the nonepidemic period in the Northeast of São Paulo State endemic area J. Med. Virol. (IF 12.7) Pub Date : 2024-03-14 Debora Glenda Lima de La‐Roque, Elaine Vieira Santos, Renata Aparecida Machado Oliveira, Svetoslav Nanev Slavov, Evandra S. Rodrigues, Vagner Fonseca, Antonio Jorge Martins, Denise Bergamaschi Giomo, Paula Marilia Afonso Torres, Danielle Cristina Dacanal Gentil, Erika Aparecida Catoia, Natalia do Carmo Chiquito, Alessandra Paula Silva Soares Medeiros, Aparecida Y. Yamamoto, Luzia Márcia Romanholi Passos
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High Torque teno virus load and outcome of patients undergoing allogeneic hematopoietic cell transplantation J. Med. Virol. (IF 12.7) Pub Date : 2024-03-14 Micha Srour, Corentin Grenier, Leonardo Magro, Didier Hober, Ibrahim Yakoub‐Agha, Ilka Engelmann
Quantification of Torque teno virus (TTV) load emerged as a marker of immunosuppression. Associations of TTV load with complications and survival after allogeneic hematopoietic cell transplantation (allo‐HCT) were controversial in published studies. In this prospective study, we aimed to identify factors influencing TTV load after allo‐HCT and to determine whether the TTV load is associated with complications
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SIAH1 modulates antiviral immune responses by targeting deubiquitinase USP19 J. Med. Virol. (IF 12.7) Pub Date : 2024-03-14 Asela Weerawardhana, Thilina U. B. Herath, W. A. Gayan Chathuranga, Tae‐Hwan Kim, Pathum Ekanayaka, Kiramage Chathuranga, Ho‐Chul Kang, Jae U. Jung, Jong‐Soo Lee
Tight control of the type I interferon (IFN) signaling pathway is critical for maintaining host innate immune responses, and the ubiquitination and deubiquitination of signaling molecules are essential for signal transduction. Deubiquitinase ubiquitin‐specific protein 19 (USP19) is known to be involved in deubiquitinating Beclin1, TRAF3, and TRIF for downregulation of the type I IFN signaling. Here
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Rapid and sensitive lateral flow biosensor for the detection of GII human norovirus based on immunofluorescent nanomagnetic microspheres J. Med. Virol. (IF 12.7) Pub Date : 2024-03-14 Junshan Gao, Liang Xue, Yijing Li, Weicheng Cai, Shuidi Miao, Luobing Meng, Shaolei Ren, Jumei Zhang, Juan Wang, Shi Wu, Qinghua Ye, Ling Chen, Qihui Gu, Qingping Wu
Human norovirus (HuNoV) is the most predominant viral agents of acute gastroenteritis. Point‐of‐care testing (POCT) based on lateral flow immunochromatography (LIFC) has become an important tool for rapid diagnosis of HuNoVs. However, low sensitivity and lack of quantitation are the bottlenecks of traditional LIFC. Thus, we established a rapid and accurate technique that combined immunomagnetic enrichment
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UMP‐CMP kinase 2 inhibits ZIKV replication through activation of type I IFN signaling pathway J. Med. Virol. (IF 12.7) Pub Date : 2024-03-14 Ya Zhu, Qi Tan, Yaoqiang Shi, Qingyuan Li, Shilin Li, Wenxian Wen, He Xie, Bin Li, Xiaoqiong Duan, Limin Chen
Cytidine/uridine monophosphate kinase 2 (UMP‐CMP kinase 2, CMPK2) has been reported as an antiviral interferon‐stimulated gene (ISG). We previously observed that the expression of CMPK2 was significantly upregulated after Zika Virus (ZIKV) infection in A549 cells. However, the association and the underlying mechanisms between CMPK2 induction and ZIKV replication remain to be determined. We investigated
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Correlation between high‐risk HPV infection and p16/Ki‐67 abnormalities in Pap samples in a South Eastern Europe cohort J. Med. Virol. (IF 12.7) Pub Date : 2024-03-14 Nevine A. Shalaby, Claudiu Tudorescu‐Morjan, Catalin Gabriel Manole, Alexandra‐Antonela Iacata, Mirela Laura Popovici, Laura Iulia Grecu, Antoanela Curici
Cervical cancer (CC) is the fourth most common cause of cancer‐related deaths amongst women worldwide. CC represents a major global healthcare issue, and Romania ranks the worst in mortality rates amongst EU countries. However, the early detection of CC can be lifesaving. To understand the testing process undergone by women in Romania, we performed a retrospective study, and investigated a cohort of
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Development of a virus‐based affinity ultrafiltration method for screening virus‐surface‐protein‐targeted compounds from complex matrixes: Herbal medicines as a case study J. Med. Virol. (IF 12.7) Pub Date : 2024-03-13 Zhongyuan Li, Baohong Li, Miaomiao Liu, Zinuo Chen, Ping Li, Ruikun Du, Ming Su, Varada Anirudhan, Jazmin G. Achi, Jingzhen Tian, Lijun Rong, Qinghua Cui
Herbal medicines (HMs) are one of the main sources for the development of lead antiviral compounds. However, due to the complex composition of HMs, the screening of active compounds within these is inefficient and requires a significant time investment. We report a novel and efficient virus‐based screening method for antiviral active compounds in HMs. This method involves the centrifugal ultrafiltration
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Long or complicated mpox in patients with uncontrolled HIV infection J. Med. Virol. (IF 12.7) Pub Date : 2024-03-12 Anaïs Corma‐Gómez, Alfonso Cabello, Eva Orviz, Miguel Morante‐Ruiz, Oskar Ayerdi, Aws Al‐Hayani, Ana Muñoz‐Gómez, Ignacio De Los Santos, Cristina Gómez‐Ayerbe, David Rodrigo, Sandra De la Rosa Riestra, Sergio Reus‐Bañuls, Ana Silva‐Klug, María José Galindo, Marta Santos, Miriam Serrano‐Fuentes, Naya Faro‐Míguez, Inés Pérez‐Camacho, Diana Corona‐Mata, Luis Morano, Miguel Ángel López‐Ruz, Marta Montero
To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, the aim of this study was to assess the impact of HIV on the clinical course of mpox, in a large population of patients from Spain. Nationwide case‐series study. Patients from 18 Spanish hospitals, with PCR‐confirmed mpox from April 27, 2022 to June 30, 2023 were included
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Respiratory syncytial virus incidence and typing in the last six seasons in the north of Spain (Asturias). Genetic characterization during the SARS‐CoV‐2 pandemic J. Med. Virol. (IF 12.7) Pub Date : 2024-03-12 Susana Rojo‐Alba, Zulema Pérez Martínez, José María González‐Alba, José Antonio Boga, Cristina Ochoa Varela, Maria Agustina Alonso Álvarez, Carmen Pérez Fonseca, Marta María García Clemente, José Gutierrez Rodriguez, Estibaliz Garrido García, Mercedes Rodríguez Pérez, Santiago Melón García, Marta Elena Álvarez‐Argüelles
Respiratory syncytial virus is associated with lower respiratory tract infections. As several types and genotypes can circulate at the same time, genomic characterization is important for timely epidemiological control and treatment measures. In the last 6 seasons (2017–2023), 191 236 nasopharyngeal swabs were processed for respiratory viruses to determine the etiology of acute respiratory infections
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CXCL10 and its receptor in patients with chronic hepatitis B and their ability to predict HBeAg seroconversion during antiviral treatment with TDF J. Med. Virol. (IF 12.7) Pub Date : 2024-03-12 Jiezuan Yang, Shaoyan Xu, Jinlin Cheng, Xuying Yin, Dong Yan, Xuefen Li
The serum chemokine C‐X‐C motif ligand‐10 (CXCL10) and its unique receptor (CXCR3) may predict the prognosis of patients with chronic hepatitis B (CHB) treated with tenofovir disoproxil fumarate (TDF). Nevertheless, there are few reports on the profile of CXCL10 and CXCR3 and their clinical application in HBeAg (+) CHB patients during TDF antiviral therapy. CXCL10 and CXCR3 were determined in 118 CHB
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Clinical implications of hepatitis B virus core antigen‐mediated immunopathologic T cell responses in chronic hepatitis B J. Med. Virol. (IF 12.7) Pub Date : 2024-03-12 Li‐Tzu Wang, Yu‐Hong Chen, Yang Cheng, Hsiu‐Lung Fan, Teng‐Wei Chen, Yu‐Lueng Shih, Tsai‐Yuan Hsieh, Wen‐Yen Huang, Wei‐Chen Huang
Hepatitis B virus (HBV) infection significantly impacts Asian populations. The influences of continuous HBV antigen and inflammatory stimulation to T cells in chronic hepatitis B (CHB) remain unclear. In this study, we first conducted bioinformatics analysis to assess T‐cell signaling pathways in CHB patients. In a Taiwanese cohort, we examined the phenotypic features of HBVcore‐specific T cells and
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Low antibody levels associated with significantly increased rate of SARS‐CoV‐2 infection in a highly vaccinated population from the US National Basketball Association J. Med. Virol. (IF 12.7) Pub Date : 2024-03-11 Caroline G. Tai, Miriam J. Haviland, Steven M. Kissler, Rachel M. Lucia, Michael Merson, Lisa L. Maragakis, David D. Ho, Deverick J. Anderson, John DiFiori, Nathan D. Grubaugh, Yonatan H. Grad, Christina DeFilippo Mack
SARS‐CoV‐2 antibody levels may serve as a correlate for immunity and could inform optimal booster timing. The relationship between antibody levels and protection from infection was evaluated in vaccinated individuals from the US National Basketball Association who had antibody levels measured at a single time point from September 12, 2021, to December 31, 2021. Cox proportional hazards models were
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Exploring the incidence of peripheral arterial occlusive disease following COVID‐19 infection: A retrospective cohort study J. Med. Virol. (IF 12.7) Pub Date : 2024-03-11 Liang‐Tsai Yeh, Chi‐Ho Chan, Yu‐Hsun Wang, Chia‐Yi Lee, Shun‐Fa Yang, Chao‐Bin Yeh
Peripheral arterial occlusive disease (PAOD) is a clinical manifestation of systemic atherosclerosis and is always associated with cerebrovascular disease and various complications. The aim of our study is to evaluate the relationship between the coronavirus disease 2019 (COVID‐19) infection and the subsequent PAOD development. A retrospective cohort study was conducted and individuals with COVID‐19
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Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study J. Med. Virol. (IF 12.7) Pub Date : 2024-03-08 Cassie Lee, Darren C. Greenwood, Harsha Master, Kumaran Balasundaram, Paul Williams, Janet T. Scott, Conor Wood, Rowena Cooper, Julie L. Darbyshire, Ana Espinosa Gonzalez, Helen E. Davies, Thomas Osborne, Joanna Corrado, Nafi Iftekhar, Natalie Rogers, Brendan Delaney, Trish Greenhalgh, Manoj Sivan
Orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (PoTS) and orthostatic hypotension (OH), are often reported in long covid, but published studies are small with inconsistent results. We sought to estimate the prevalence of objective OI in patients attending long covid clinics and healthy volunteers and associations with OI symptoms and comorbidities. Participants with
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Structure‐based design of diarylpyrimidines and triarylpyrimidines as potent HIV‐1 NNRTIs with improved metabolic stability and drug resistance profiles J. Med. Virol. (IF 12.7) Pub Date : 2024-03-07 Minghui Xie, Zhao Wang, Fabao Zhao, Ye Li, Zongji Zhuo, Xin Li, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang
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The pathophysiological and immunological background of the monkeypox virus infection: An update J. Med. Virol. (IF 12.7) Pub Date : 2024-03-07
Mukherjee AG, Wanjari UR, Kannampuzha S, et al. The pathophysiological and immunological background of the monkeypox virus infection: an update. J Med Virol. 2023;95:e28206. https://doi.org/10.1002/jmv.28206 This Expression of Concern is for the above article, published online on October 11, 2022 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10.1002/jmv.28206), and has been published
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Empowering SARS‐CoV‐2 variant neutralization with a bifunctional antibody engineered with tandem heptad repeat 2 peptides J. Med. Virol. (IF 12.7) Pub Date : 2024-03-06 Ji Woong Kim, Ji Hyun Lee, Hyun Jung Kim, Kyun Heo, Yoonwoo Lee, Hui Jeong Jang, Ho‐Young Lee, Jun Won Park, Yea Bin Cho, Ha Gyeong Shin, Ha Rim Yang, Hee Eon Lee, Jin Young Song, Sukmook Lee
With the global pandemic and the continuous mutations of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the need for effective and broadly neutralizing treatments has become increasingly urgent. This study introduces a novel strategy that targets two aspects simultaneously, using bifunctional antibodies to inhibit both the attachment of SARS‐CoV‐2 to host cell membranes and viral fusion
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Comment on “The association of sickle cell disorder with adverse outcomes in COVID‐19 patients: A meta‐analysis” J. Med. Virol. (IF 12.7) Pub Date : 2024-03-06 I‐Wen Chen, Hsiu‐Jung Lin, Yao‐Tsung Lin, Kuo‐Chuan Hung
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The expression analysis of human endogenous retrovirus‐K Env, Np9, and Rec transcripts in cervical cancer J. Med. Virol. (IF 12.7) Pub Date : 2024-03-06 Rahim Soleimani‐Jelodar, Arash Arashkia, Zabihollah Shoja, Setareh Akhavan, Fariba Yarandi, Kimia Sharifian, Mohammad Farahmand, Fatemeh Nili, Somayeh Jalilvand
While infection with high‐risk human papillomavirus (HPV) types is necessary for cervical cancer (CC) development, it is not enough, and other risk factors are required. Several studies have reported the activation of HERV‐K in different cancers; however, the investigation of HERV‐K expression levels in CC is scarce. In this study, it was hypothesized that activation of HERV‐K could play an essential
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Dynamic bidirectional regulation of NLRC3 and gammaherpesviruses during viral latency in B lymphocytes J. Med. Virol. (IF 12.7) Pub Date : 2024-03-06 Hye‐Ri Kang, Ji Ho Han, Yee Ching Ng, Seungbo Ryu, Ji‐Yeon Park, Woo‐Chang Chung, Yoon‐Jae Song, Szu‐Ting Chen, W. June Brickey, Jenny P.‐Y. Ting, Moon Jung Song
While most NOD‐like receptors (NLRs) are predominately expressed by innate immune cells, NLRC3, an inhibitory NLR of immune signaling, exhibits the highest expression in lymphocytes. The role of NLRC3 or any NLRs in B lymphocytes is completely unknown. Gammaherpesviruses, including human Epstein–Barr virus (EBV) and murine gammaherpesvirus 68 (MHV‐68), establish latent infection in B lymphocytes, which
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A superior heterologous prime‐boost vaccination strategy against COVID‐19: A bivalent vaccine based on yeast‐derived RBD proteins followed by a heterologous vaccine J. Med. Virol. (IF 12.7) Pub Date : 2024-03-06 Yu Liu, Miao Li, Tingting Cui, Zhian Chen, Liangting Xu, Wenjuan Li, Qinhua Peng, Xingxing Li, Danhua Zhao, C. Alexander Valencia, Biao Dong, Zhongfang Wang, Hoi Yee Chow, Yuhua Li
Various vaccines have been challenged by SARS‐CoV‐2 variants. Here, we reported a yeast‐derived recombinant bivalent vaccine (Bivalent wild‐type [Wt]+De) based on the wt and Delta receptor‐binding domain (RBD). Yeast derived RBD proteins based on the wt and Delta mutant were used as the prime vaccine. It was found that, in the presence of aluminium hydroxide (Alum) and unmethylated CpG‐oligodeoxynucleotides
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Identification and genetic characterization of a recently identified enterovirus C116 in China J. Med. Virol. (IF 12.7) Pub Date : 2024-03-06 Zhen‐Zhi Han, Ji‐Chen Li, Jin‐Bo Xiao, Mei Hong, Huan‐Huan Lu, Yang Song, Ying Liu, Rui Wang, Han‐Haoyu Fu, Fang‐Ming Wang, Shuang‐Li Zhu, Dong‐Mei Yan, Tian‐Jiao Ji, Lin‐Qing Zhao, Yong Zhang
Enterovirus C116 (EV‐C116) is a new member of the enterovirus C group which is closely associated with several infectious diseases. Although sporadic studies have detected EV‐C116 in clinical samples worldwide, there is currently limited information available. In this study, two EV‐C‐positive fecal specimens were detected in apparently healthy children, which harbored low abundance, through meta‐transcriptome
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Novel influenza viral vectored vaccine against respiratory syncytial virus J. Med. Virol. (IF 12.7) Pub Date : 2024-03-05 Michaela Cain, Hinh Ly
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Should we use risk selection tests for HPV 16 and/or 18 positive cases: Comparison of p16/Ki67 and cytology J. Med. Virol. (IF 12.7) Pub Date : 2024-03-05 Karolina Mazurec, Martyna Trzeszcz, Maciej Mazurec, Joanna Streb, Agnieszka Halon, Robert Jach
Major screening abnormalities in precolposcopic stage are tests results that imply direct referral to colposcopy (and/or expedited treatment) without performing additional high‐grade squamous intraepithelial lesions or worse (HSIL+) risk selection testing. Currently, both clinically validated HSIL+ risk selection tests, reflex cytology and reflex p16/Ki67 dual staining (DS), are being compared for
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Identifying COVID‐19 subtypes by single‐sample gene set enrichemnt analysis and providing guidance for sensitive drug selection J. Med. Virol. (IF 12.7) Pub Date : 2024-03-04 Nan Xiong, Qiangming Sun
This study aimed at using single‐sample gene set enrichment analysis scores to cluster naso/pharyngeal swab specimen samples from coronavirus disease 2019 (COVID‐19) patients into two clusters. One cluster with higher fractions of immune cells and more active inflammatory‐related pathways was called the Immunity‐High (Immunity‐H) group, and the other one was called the Immunity‐Low group. We explored
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Improved fluorescence‐based assay for rapid screening and evaluation of SARS‐CoV‐2 main protease inhibitors J. Med. Virol. (IF 12.7) Pub Date : 2024-03-04 Rui Zhang, Haohao Yan, Jiahao Zhou, Gangan Yan, Xiaoping Liu, Chao Shang, Yunyu Chen
The outbreak of coronavirus disease 2019 (COVID‐19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a global threat to human health. In parallel with vaccines, efficacious antivirals are urgently needed. SARS‐CoV‐2 main protease (Mpro) is an attractive drug target for antiviral development owing to its key roles in virus replication and host immune evasion. Due
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Clinical and immunological features of COVID‐19 in patients with anti‐MDA5 dermatomyositis during the omicron wave in Chongqing, China J. Med. Virol. (IF 12.7) Pub Date : 2024-03-04 Na Wu, Zhiwei Chen, Guanhua Zha, Zhiling Deng, Wenhan Huang, Dachuan Cai, Mingli Peng, Peng Hu, Lin Tang, Hong Ren
Patients with anti‐melanoma differentiation‐associated gene 5 (anti‐MDA5) dermatomyositis (DM) have a higher risk of coronavirus disease 2019 (COVID‐19) infection. In this longitudinal observational study, we aimed to investigate the clinical and immunological features of these patients after COVID‐19 infection. A total of 73 patients with anti‐MDA5 DM were recruited from the Second Affiliated Hospital
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Retraction: “Safety and immunogenicity of a recombinant receptor‐binding domain‐based protein subunit vaccine (Noora vaccine™) against COVID‐19 in adults: A randomized, double‐blind, placebo‐controlled, Phase 1 trial” J. Med. Virol. (IF 12.7) Pub Date : 2024-03-02
Retraction: “Safety and immunogenicity of a recombinant receptor‐binding domain‐based protein subunit vaccine (Noora vaccine™) against COVID‐19 in adults: A randomized, double‐blind, placebo‐controlled, Phase 1 trial,” by Salimian J, Ahmadi A, Amani J, et al. J Med Virol. 2022;95:e28097. The above article, published online on August 27, 2022 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10
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A subunit‐based influenza/SARS‐CoV‐2 Omicron combined vaccine induced potent protective immunity in BALB/c mice J. Med. Virol. (IF 12.7) Pub Date : 2024-03-01 Naru Zhang, Zihui Ye, Cun Li, Jie Zhou, Wei Xue, Luying Xiang, Yuewen Chen, Shuchang Chen, Rouhan Ye, Jingyin Dong, Jie Zhou, Shibo Jiang, Haijun Han
Infection with influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses a significant risk to human life, health, and the global economy. Vaccination is one of the most effective strategies in the fight against infectious viruses. In this study, we, for the first time, have evaluated the immunogenicity and protective effect of an influenza/SARS‐CoV‐2 Omicron subunit
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Biosensor‐based multiple cross displacement amplification platform for visual and rapid identification of hepatitis C virus J. Med. Virol. (IF 12.7) Pub Date : 2024-03-01 Xu Chen, Shilei Dong, Yuanfang Shi, Zengguang Wu, Xue Wu, Xiaoyan Zeng, Xinggui Yang, Qi Zhao, Zhenghua Xiao, Qingxue Zhou
Hepatitis C remains a global health problem, especially in poverty‐stricken areas. A rapid and sensitive point‐of‐care (POC) diagnostic tool is critical for the early detection and timely treatment of hepatitis C virus (HCV) infection. Here, for the first time, we reported a novel molecular diagnostic assay, termed reverse transcription multiple cross displacement amplification integrated with a g
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Consistency in human papillomavirus type detection between self‐collected vaginal specimens and physician‐sampled cervical specimens J. Med. Virol. (IF 12.7) Pub Date : 2024-02-29 Hung‐Hsueh Chou, Chung‐Yao Yang, Angel Chao, Hao Lin, Chien‐Hsing Lu, Yu‐Che Ou, Shih‐Tien Hsu, Yu‐Hsiang Shih, Huei‐Jean Huang, Cheng‐Tao Lin, Min‐Yu Chen, Lou Sun, Ching‐Chou Tsai, Hung‐Chun Fu, Kuan‐Gen Huang, Kai‐Yun Wu, Chen‐Hsuan Wu, Wu‐Chiao Hsieh, Yi‐Ting Huang, Liang‐Hsuan Chen, Lan‐Yan Yang, Wei‐Yang Chang, Ting‐Chang Chang, Chyong‐Huey Lai
With the rising need for accessible cervical cancer screening, self‐sampling methods offer a promising alternative to traditional physician‐led sampling. This study aims to evaluate the efficacy of the HygeiaTouch Self Sampling Kit for Women in detecting human papillomavirus (HPV) types and predicting cervical lesions. We studied the concordance in identifying high‐risk HPV (hrHPV) types between samples
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Assisted reproductive technology treatment failure and the detection of intrauterine HPV through spent embryo transfer media sample J. Med. Virol. (IF 12.7) Pub Date : 2024-02-28 Mingzhu Bai, Di Sun, Jinhui Shu, Dong Wei, Mu Yuan, Zhenya Yuan, Suying Liu, Mei Kang, Zikai Zhang, Xiong Chen, Wenxin Zheng, Youji Feng, Shihua Bao, Zhenbo Zhang, Hong Liao
Cervical human papillomavirus (HPV) infection is believed to increase the risks of pregnancy failure and abortion, however, whether the uterine cavity HPV infection reduces pregnancy rate or increases miscarriage rate remains unclarified in infertile women undergoing assisted reproductive technology (ART) treatment. Therefore, we aimed to assess ART outcomes in the presence of intrauterine HPV. This
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The characteristics of BCR‐CDR3 repertoire in COVID‐19 patients and SARS‐CoV‐2 vaccinated volunteers J. Med. Virol. (IF 12.7) Pub Date : 2024-02-28 Jiaping Xiao, Yan Luo, Yangyang Li, Xinsheng Yao
The global COVID‐19 pandemic has caused more than 1 billion infections, and numerous SARS‐CoV‐2 vaccines developed rapidly have been administered over 10 billion doses. The world is continuously concerned about the cytokine storms induced by the interaction between SARS‐CoV‐2 and host, long COVID, breakthrough infections postvaccination, and the impact of SARS‐CoV‐2 variants. BCR‐CDR3 repertoire serves
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Genotype, cervical intraepithelial neoplasia, and type‐specific cervical intraepithelial neoplasia distributions in hrHPV+ cases referred to colposcopy: A multicenter study of Chinese mainland women J. Med. Virol. (IF 12.7) Pub Date : 2024-02-28 Mingyang Chen, Zichen Ye, Huike Wang, Xiaoli Cui, Samuel Seery, Aiyuan Wu, Peng Xue, Youlin Qiao
To investigate age and type‐specific prevalences of high‐risk human papillomavirus (hrHPV) and cervical intraepithelial neoplasia (CIN) in hrHPV+ women referred to colposcopy. This is a retrospective, multicenter study. Participants were women referred to one of seven colposcopy clinics in China after testing positive for hrHPV. Patient characteristics, hrHPV genotyping, colposcopic impressions, and
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Comment on “The risk assessment of uveitis after COVID‐19 diagnosis” J. Med. Virol. (IF 12.7) Pub Date : 2024-02-25 Patrick Wu, Chin‐Yuan Yii, Su‐Boon Yong
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Eliminating cervical cancer in China: Opportunities come and challenges remain J. Med. Virol. (IF 12.7) Pub Date : 2024-02-25 Xu Ou‐Yang, Yang Cao, Qihao Leng, Yan Wang, Hang Yi, Guochao Zhang
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Classic human astrovirus 4, 8, MLB‐3, and likely new genotype 5 sublineage in stool samples of children in Nigeria J. Med. Virol. (IF 12.7) Pub Date : 2024-02-25 Ifeorah M. Ijeomah, Faleye O. C. Temitope, De Coninck Lander, Agbaje T. Sheriff, George E. Uwem, Onoja A. Bernard, Olayinka A. Oluseyi, Oni I. Elijah, Ajileye G. Toluwani, Oragwa O. Arthur, Akinleye E. Toluwanimi, Popoola O. Bolutife, Osasona G. Damilola, Olayinka O. Titilola, George A. Oluwadamilola, Ahmed I. Muhammad, Komolafe I. Omotosho, Adeniji A. Johnson, Matthijnssens Jelle, Adewumi M. Olubusuyi
Human astrovirus (HAstV) is a nonenveloped RNA virus and has been implicated in acute gastroenteritis among children and elderly. However, there exists a substantial dearth of information on HAstV strains circulating in Nigeria. Viral‐like particles were purified from archived 254 stool samples of children with acute flaccid paralysis between January and December 2020 from five states in Nigeria, using
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IFITM3 inhibits severe fever with thrombocytopenia syndrome virus entry and interacts with viral Gc protein J. Med. Virol. (IF 12.7) Pub Date : 2024-02-25 Shouwen Du, Yuhang Wang, Jiamin Wang, Yidan Ma, Wang Xu, Xiaoshuang Shi, Letian Li, Pengfei Hao, Quan Liu, Ming Liao, Boping Zhou, Ningyi Jin, Yin K. Wong, Lifen Hu, Jigang Wang, Wei Liu, Chang Li
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick‐borne hemorrhagic fever disease with high fatality rate of 10%–20%. Vaccines or specific therapeutic measures remain lacking. Human interferon inducible transmembrane protein 3 (hIFITM3) is a broad‐spectrum antiviral factor targeting viral entry. However, the antiviral activity of hIFITM3 against SFTS virus (SFTSV) and the functional
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A protectin DX (PDX) analog with in vitro activity against influenza A(H1N1) viruses J. Med. Virol. (IF 12.7) Pub Date : 2024-02-25 Nicolas Fortin, Mathilde Hénaut, Nathalie Goyette, René Maltais, Jean‐Yves Sancéau, André Marette, Donald Poirier, Yacine Abed, Guy Boivin
Antiviral therapy based on neuraminidase (oseltamivir) or polymerase (baloxavir marboxil) inhibitors plays an important role in the management of influenza infections. However, the emergence of drug resistance and the uncontrolled inflammatory response are major limitations in the treatment of severe influenza disease. Protectins D1 (PD1) and DX (PDX), part of a family of pro‐resolving mediators, have
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Analytical evaluation of the automated genotyping system (GenPlex) compared to a traditional real‐time PCR assay for the detection of high‐risk human papillomaviruses J. Med. Virol. (IF 12.7) Pub Date : 2024-02-25 Lijuan Zhang, Yan Ju, Haixu Hu, Chunhui Ma, Yanju Yu, Yan Huang, Lili Gong, Wei Zhao, Yujia Liu, Yi Liu, Lihong Bian
The detection of high‐risk human papillomaviruses (HPVs) is crucial for early screening and preventing cervical cancer. However, the substantial workload in high‐level hospitals or the limited resources in primary‐level hospitals hinder widespread testing. To address this issue, we explored a sample‐to‐answer genotyping system and assessed its performance by comparing it with the traditional real‐time
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Phylodynamic evolution of HIV‐1 A6 sub‐subtype epidemics in Poland J. Med. Virol. (IF 12.7) Pub Date : 2024-02-21 Karol Serwin, Kaja Scheibe, Anna Urbańska, Bogusz Aksak‐Wąs, Malwina Karasińska‐Cieślak, Piotr Ząbek, Ewa Siwak, Iwona Cielniak, Elżbieta Jabłonowska, Kamila Wójcik‐Cichy, Paweł Jakubowski, Monika Bociąga‐Jasik, Adam Witor, Aleksandra Szymczak, Bartosz Szetela, Miłosz Parczewski
The human immunodeficiency virus type 1 (HIV‐1) A6 sub‐subtype is highly prevalent in Eastern Europe. Over the past decade, the dissemination of the A6 lineage has been expanding in Poland. The recent Russian invasion of Ukraine may further escalate the spread of this sub‐subtype. While evolutionary studies using viral sequences have been instrumental in identifying the HIV epidemic patterns, the origins
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A role of BPTF in viral oncogenicity delineated through studies of heritable Kaposi sarcoma J. Med. Virol. (IF 12.7) Pub Date : 2024-02-21 Yuval Yogev, Moshe Schaffer, Mark Shlapobersky, Matan M. Jean, Ohad Wormser, Max Drabkin, Daniel Halperin, Riad Kassem, Alejandro Livoff, Alexandra A. Tsitrina, Noam Asna, Ohad S. Birk
Kaposi sarcoma (KS), caused by Herpesvirus‐8 (HHV‐8; KSHV), shows sporadic, endemic, and epidemic forms. While familial clustering of KS was previously recorded, the molecular basis of hereditary predilection to KS remains largely unknown. We demonstrate through genetic studies that a dominantly inherited missense mutation in BPTF segregates with a phenotype of classical KS in multiple immunocompetent
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Effect of inactivated vaccine boosters against severe and critical COVID‐19 during the Omicron BA.5 wave: A retrospective analysis of hospitalized patients in China J. Med. Virol. (IF 12.7) Pub Date : 2024-02-21 Jiadi Gan, Huohuo Zhang, Jiaxuan Wu, Yi Liu, Pingping Liu, Ruixin Cheng, Xiumei Tang, Linhui Yang, Wenxin Luo, Weimin Li
Few real‐world analyses of the ability of vaccines to protect against severe COVID‐19 have been published. In this real‐world study, we compared the prevalence of severe or critical COVID‐19 between patients at our hospital who were not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) or who had been vaccinated partial, full, or booster course with the CoronaVac, containing
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Hepatitis B virus‐related hepatocellular carcinoma exhibits distinct intratumoral microbiota and immune microenvironment signatures J. Med. Virol. (IF 12.7) Pub Date : 2024-02-20 Yuanjie Liu, Elena S. Kim, Haitao Guo
Emerging evidence supports a high prevalence of cancer type‐specific microbiota residing within tumor tissues. The intratumoral microbiome in hepatocellular carcinoma (HCC), especially in viral (hepatitis B virus [HBV]/hepatitis C virus [HCV]) HCC, has not been well characterized for their existence, composition, distribution, and biological functions. We report herein a finding of specific microbial
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First RSV epidemic with nirsevimab. Older children than previous epidemics, even when hospitalized J. Med. Virol. (IF 12.7) Pub Date : 2024-02-20 Aymeric Cantais, Nadine Annino, Charlotte Thuiller, Louise Tripodi, Philippine Cesana, Eloise Seigle‐Ferrand, Franck Zekre, Sylvie Pillet, Bruno Pozzetto
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The evolutionary phylodynamics of human parechovirus A type 3 reveal multiple recombination events in South Korea J. Med. Virol. (IF 12.7) Pub Date : 2024-02-20 Thoi C. Truong, Heekuk Park, Jong‐Hwa Kim, Van Trung Tran, Wonyong Kim
Human parechovirus A (HPeV‐A) is a causative agent of respiratory and gastrointestinal illnesses, acute flaccid paralysis encephalitis, meningitis, and neonatal sepsis. To clarify the characteristics of HPeV‐A infection in children, 391 fecal specimens were collected from January 2014 to October 2015 from patients with acute gastroenteritis in Seoul, South Korea. Of these, 221/391 (56.5%) HPeV‐A positive
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Progression of retinal choroidal neovascularization by latent human cytomegalovirus infection and immunological signaling among neonatal patients admitted to tertiary care hospital J. Med. Virol. (IF 12.7) Pub Date : 2024-02-20 Debsopan Roy, Aroni Chatterjee, Lopamudra Mishra, Nilanjan Chakraborty
Choroidal neovascularization (CNV) is a serious condition that affects the retina, causing partial or complete blindness in people of different ages. While CNV is a common occurrence in various chorioretinopathies, research on its occurrence in neonates is limited. Human cytomegalovirus (HCMV) is a significant health threat to neonates, with a strong association with retinal angiogenesis. However,
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Risk factors for human papillomavirus infection and disease: A targeted literature summary J. Med. Virol. (IF 12.7) Pub Date : 2024-02-20 Marta del Pino, Alex Vorsters, Elmar A. Joura, John Doorbar, Marta Haniszewski, Irene Asensio Gudina, Petya Kodjamanova, Christine Velicer, Rosybel Drury
Adolescents are the primary cohort for routine human papillomavirus (HPV) vaccination, but unvaccinated adults may also benefit. A lack of consensus on which adults to target and the presence of reimbursement barriers likely contribute to the lag in adult vaccinations, highlighting missed prevention opportunities. Understanding factors contributing to risk of HPV infection and disease could help in
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A field diagnostic method for rapid and sensitive detection of mpox virus J. Med. Virol. (IF 12.7) Pub Date : 2024-02-20 Fei Zhao, Fengwen Xu, Xinming Wang, Rui Song, Yamei Hu, Liang Wei, Yu Xie, Yu Huang, Shan Mei, Liming Wang, Lingwa Wang, Zhao Gao, Li Guo, Jugao Fang, Lili Ren, Ronghua Jin, Jianwei Wang, Fei Guo
The mpox outbreak has subdued with fewer reported cases at the present in high‐income countries. It is known that mpox virus (MPXV) infection has been epidemic for more than 50 years in African countries. The ancestral MPXV strain has changed into multiple clades, indicating the ongoing evolution of MPXV, which reflects the historical neglect of mpox in Africa, especially after smallpox eradication
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Effectiveness of nirmatrelvir‐ritonavir on severe outcomes of COVID‐19 in the era of vaccination and Omicron: An updated meta‐analysis J. Med. Virol. (IF 12.7) Pub Date : 2024-02-20 Sien Ombelet, Diego Castanares‐Zapatero, Fabian Desimpel, Frank Hulstaert, Sabine Stordeur, Dominique Roberfroid
Nirmatrelvir‐ritonavir (NR) was approved to treat SARS‐CoV‐2 positive outpatients at high risk of progression to severe disease, based on a randomized trial in unvaccinated patients. Effectiveness in vaccinated patients and against Omicron has not yet been confirmed by clinical trial data, but a recent meta‐analysis suggested good real‐world effectiveness based on 12 studies. We updated this meta‐analysis
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On coming back, the scaring COVID‐19 concern. Addressing indoor microclimates with innovative and straightforward solutions to prevent SARS‐CoV2 spreading J. Med. Virol. (IF 12.7) Pub Date : 2024-02-20 Salvatore Chirumbolo, Umberto Tirelli
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Haemovigilance survey and screening strategy for arthropod‐borne viruses in blood donors from Argentina J. Med. Virol. (IF 12.7) Pub Date : 2024-02-19 Sebastián Blanco, Ángeles Lorena Marín, María Celia Frutos, Nubia Yandar Barahona, María Elisa Rivarola, Luis Horacio Carrizo, Lorena Spinsanti, Sandra Verónica Gallego
Arthropod‐borne viruses (arboviruses) count among emerging infections, which represent a major challenge for transfusion safety worldwide. To assess the risk of arboviruses‐transmission by transfusion (ATT), we performed a survey to evaluate the potential threat for transfusion safety. Samples were retrospectively and randomly collected from donors who donated during the peak of dengue incidence in
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Simultaneous identification of DNA and RNA pathogens using metagenomic sequencing in cases of severe acute respiratory infection J. Med. Virol. (IF 12.7) Pub Date : 2024-02-19 Nana Xie, Yanfeng Lin, Peihan Li, Jiachen Zhao, Jinhui Li, Kaiying Wang, Lang Yang, Leili Jia, Quanyi Wang, Peng Li, Hongbin Song
Metagenomic next‐generation sequencing (mNGS) is a valuable technique for identifying pathogens. However, conventional mNGS requires the separate processing of DNA and RNA genomes, which can be resource‐ and time‐intensive. To mitigate these impediments, we propose a novel method called DNA/RNA cosequencing that aims to enhance the efficiency of pathogen detection. DNA/RNA cosequencing uses reverse
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Dominant epitopes of cross‐reactive anti‐domain III human antibody response change from early to late convalescence of infection with dengue virus J. Med. Virol. (IF 12.7) Pub Date : 2024-02-19 Luis Gabriel González‐Lodeiro, Alejandro Martín Dunn, Dayron Martín Prieto, Danya Medina‐Carrasco, Lisandra E. García de Castro, Daniela Maldonado Bauzá, Glay Chinea Santiago, Vivian Huerta Galindo
Cross‐neutralizing activity of human antibody response against Dengue virus complex (DENV) changes importantly over time. Domain III (DIII) of the envelope protein of DENV elicits a potently neutralizing and mostly type‐specific IgG response. We used sera from 24 individuals from early‐ or late convalescence of DENV1 infection to investigate the evolution of anti‐DIII human IgG with the time lapse