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Antemortem inhibition of phosphoinositide 3-kinase causes changes in meat quality traits in broiler chickens Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-12-24 T. Nakanishi; K. Watanabe; L. Erickson; S. Kawahara
Phosphoinositide 3-kinase (PI3K) is an enzyme that mediates endocrinological responses, such as intracellular signaling of insulin and growth factors, and plays important roles in muscle homeostasis and growth. In this study, the effect of antemortem PI3K activity on meat quality traits was investigated using broiler chickens whose PI3K was inhibited pharmacologically. Breast and thigh muscles were
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An incremental feeding pattern for Guangdong Small-ear Spotted gilts during gestation: effects on stillbirth rate and muscle weight of progeny Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2021-01-11 J.F. Wei; S.B. Huang; P. Jin; J.Y. Li; Y.Y. Yang; C.J. Hu; L.F. Yang; Z.W. Zhang; M. Deng; J.P. Deng
While an appropriate feed intake is crucial for the reproductive performance of sows, there is a lack of recommendations currently for feed allowance of Guangdong Small-ear Spotted gilts during gestation. The effects of two different feeding patterns during gestation on the reproductive performance of Guangdong Small-ear Spotted gilts were investigated by assigning 80 gilts to two feeding pattern groups
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Effects of dietary antioxidants on glucose and insulin responses to glucose tolerance test in transition dairy cows Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-12-01 A. Chalmeh; M. Pourjafar; K. Badiei; A. Mirzaei; M. Jalali; M. Mazrouei Sebdani
Oxidative stress occurs during the transition period and causes insulin resistance, which may be reduced by the use of antioxidants in this period. Twenty-four multiparous Holstein dairy cows, at 8 wk before parturition, were divided into 4 equal groups, namely control (Ctrl), vitamin E (VE), selenium (Se), and vitamin E plus selenium (VE + Se) groups. On a daily basis, VE and Se cows received dietary
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Endocrine, prostatic vascular, and proapoptotic changes in dogs with benign prostatic hyperplasia treated medically or surgically Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-11-23 C.B. Lima; D.S.R. Angrimani; R.B. Flores; C.I. Vannucchi
Benign prostatic hyperplasia (BPH) is a disorder related to hormone imbalance, local angiogenesis, and prostate growth, which can be treated surgically (orchiectomy) or medically (most commonly with finasteride). However, finasteride therapy is not completely established in dogs regarding local action and posology. This study aimed to evaluate the effect of different doses of finasteride and orchiectomy
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Comparison of pharmacodynamics between insulin glargine 100 U/mL and insulin glargine 300 U/mL in healthy cats Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-11-17 N.K. Saini; B. Wasik; J. Pires; D.M. Leale; N. Quach; W.T.N. Culp; R.J. Samms; A.E. Johnson; J.G. Owens; C. Gilor
Insulin glargine (IGla) is a synthetic human-recombinant insulin analog that is used routinely in people as a q24h basal insulin. The 300 U/mL (U300) formulation of IGla is associated with longer duration of action and less within-day variability, making it a better basal insulin compared with the 100 U/mL (U100) formulation. We hypothesized that in healthy cats, IGlaU300 has a flatter time-action
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Orexin B inhibits viability and differentiation of stromal cells from swine adipose tissue Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-11-12 G. Basini; S. Bussolati; S. Grolli; L. Ragionieri; R. Di Lecce; F. Grasselli
Adipose tissue is recognized as a fundamental endocrine organ. Nowadays, we are also aware that it contains the highest number of stromal cells (ASCs) per unit of volume. These cells can differentiate between different phenotypes among which the adipocytes. The aim of this work was to verify whether orexin B, crucial mediator of the energy balance, modifies the differentiation of cultured ASCs. We
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A functional variant in the promoter region of IGF1 gene is associated with chicken abdominal fat deposition Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-11-07 W.J. Wang; Y.Q. Guo; K.J. Xie; Y.D. Li; Z.W. Li; N. Wang; F. Xiao; H.S. Guo; H. Li; S.Z. Wang
Insulin-like growth factor 1 (IGF1) plays an important role in the regulation of cell growth, proliferation, differentiation, and apoptosis. Previously several studies revealed that genotypes of chicken IGF1 c.-366A > C were significantly associated with abdominal fat weight and body weight in chickens. But the underlying mechanism is still unknown. To investigate the mechanism underlying the association
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Transcriptional and translational abundance of visfatin (NAMPT) in buffalo ovary during estrous cycle and its in vitro effect on steroidogenesis Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-11-05 A. Thakre; M. Gupta; S.P. Magar; K.B. Bahiram; V.M. Sardar; J.P. Korde; S.W. Bonde; I. Hyder
Visfatin is a highly conserved adipokine protein having multiple biological effects, including regulation of reproduction. Evidence in recent years has shown a pivotal role of visfatin in ovarian functions. The present study was conducted to evaluate the mRNA and protein abundance of visfatin in ovarian follicles and corpora lutea (CL) during different stages of their development in the ovary of water
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Effect of follicle size on hormonal status of follicular fluid, oocyte ATP content, and in vitro embryo production in prepubertal sheep Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-11-02 I. Contreras-Solís; M. Catalá; S. Soto-Heras; M. Roura; M.T. Paramio; D. Izquierdo
The aim of this study was to assess the effect of follicular size on estradiol (E2) and progesterone (P4) levels in intrafollicular fluid, ATP content in oocytes, and the embryo development rate in prepubertal sheep. Slaughterhouse ovaries were dissected to recover the follicles, which were classified according to the follicle diameter as <3 mm (n = 20) and ≥3 mm (n = 17). Then, follicular fluid was
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Effect of alpine grazing on plasma and hair cortisol, serotonin, and DHEA in dairy cows and its welfare impact Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-10-23 J.G. Nejad; B.-H. Lee; J.-Y. Kim; B. Chemere; K.-I. Sung; H.-G. Lee
Through the analysis of blood and hair samples, this study evaluated the effects of grazing in alpine areas on welfare indices and indicators of stress in dairy cows. Twenty-one Holstein dairy cows (body weight: 637 ± 21.5 kg; days in milk: 133 ± 17.7, and second parity) were randomly assigned to 3 groups: control (nongrazing), 12 h of alpine grazing (12 hG), and 24 h of alpine grazing (24 hG). Blood
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Field efficacy and safety of protamine zinc recombinant human insulin in 276 dogs with diabetes mellitus Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-10-14 C.R. Ward; K. Christiansen; J. Li; W.L. Bryson; K.A. Jerrentrup; C. Kroh
Twice-daily (BID) insulin injections are a major deterrence to owners treating dogs with diabetes mellitus (DM). The hypothesis for this study was that Protamine Zinc Recombinant Human Insulin (PZIR) is safe and efficacious as a once-daily (SID) treatment for canine DM. This was a prospective, baseline-controlled, multi-center study over 182 ± 5 d. Two hundred seventy-six client-owned dogs with naturally
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Administration of a single dose of 300 IU of human chorionic gonadotropin seven days after the onset of estrus improves pregnancy rate in dairy goats by an unknown mechanism Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-10-09 L.R. Côrtes; J.M.G. Souza-Fabjan; D.S. Dias; B.B. Martins; A.L.R.S. Maia; M.O. Veiga; E.K.N. Arashiro; F.Z. Brandão; M.E.F. Oliveira; P.M. Bartlewski; J.F. Fonseca
This study examined the effects of exogenous hCG administration on ovarian function and pregnancy rates in estrous-induced dairy goats during the transition into the breeding season. Eighty-six Toggenburg does received 60 mg of medroxyprogesterone acetate intravaginal sponge for 6 d plus 200 IU of equine chorionic gonadotropin and 30 μg of d-cloprostenol i.m. 24 h before sponge removal, and were then
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Maternal nutrient restriction alters endocrine pancreas development in fetal heifers Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-10-10 J.M. Long; L.A. Trubenbach; J.H. Pryor; C.R. Long; T.A. Wickersham; J.E. Sawyer; M.C. Satterfield
Maternal nutrient restriction during pregnancy alters fetal programming, which modifies the growth and health of the offspring in postnatal life. In cattle, nutrient restriction during pregnancy can be a result of environmental or economic factors, but little is known about how it alters the physiology of the fetus and affects future reproductive or growth efficiency. This study used female monozygotic
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Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-10-08 C.A. Rosales-Nieto; R. Ehrhardt; A. Mantey; B. Makela; Byrem; A. Veiga-Lopez
Changes in maternal nutrition during pregnancy can result in profound effects on placental function and fetal development. Although the preconceptional period holds the potential to reprogram embryonic and placental development, little is known regarding the effects of premating nutritional manipulation on placental function and fetal and postnatal offspring growth. To test this, Polypay-Dorset sheep
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Fenofibrate treatment for severe hypertriglyceridemia in dogs Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-10-08 D.D. Miceli; V.P. Vidal; M.F.C. Blatter; O.P. Pignataro; V.A. Castillo
Lipid disorders are relatively common in dogs. Hyperlipidemia can be primary or secondary to other diseases. In humans, fenofibrate is used to control hypertriglyceridemia. In dogs, there are no studies evaluating fenofibrate in hypertriglyceridemia. The aim of the study was to evaluate the safety and efficacy of fenofibrate to control severe hypertriglyceridemia in dogs. A total of 124 dogs (n = 124)
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Transcriptome analysis of sheep follicular development during prerecruitment, dominant, and mature stages after FSH superstimulation Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-15 Y.C. Yao; X.T. Song; Y.F. Zhai; S. Liu; J. Lu; X. Xu; M.Y. Qi; J.N. Zhang; H. Huang; Y.F. Liu; G.S. Liu; H. Yuan
Sheep is usually a monovular animal; superovulation technology is used to increase the number of offspring per individual and shorten generation intervals. To date, mature FSH superstimulatory treatments have been successfully used in sheep breeding, but much remains unknown about genes, pathways, and biological functions involved in follicular development. Therefore, in this study, we performed transcriptome
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Testicular transcriptome analysis under the dietary inclusion of l-carnitine reveals potential key genes associated with oxidative defense and the semen quality factor in aging roosters Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-19 A.A. Elokil; M. Abouzaid; M. Magdy; T. Xiao; H. Liu; R. Xu; S. Li
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The myokine irisin: localization and effects in swine late medium and large antral ovarian follicle Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-24 G. Basini; S. Bussolati; M. Iannarelli; L. Ragionieri; S. Grolli; R. Ramoni; A. Dodi; F. Gazza; F. Grasselli
Irisin is mainly synthesized by skeletal muscle tissue, where it is believed to be responsible for the benefits of exercise on metabolism and cardiovascular system. In adipose tissue, its best-known effect is the browning of white adipocytes, resulting in the increase of thermogenesis and energy expenditure. As it has been largely documented that metabolic dysfunctions can frequently be associated
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Effect of maternal nutrient restriction on expression of glucose transporters (SLC2A4 and SLC2A1) and insulin signaling in skeletal muscle of SGA and Non-SGA sheep fetuses Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-10-06 C. Sandoval; K. Askelson; C.A. Lambo; K.A. Dunlap; M.C. Satterfield
Maternal nutrient restriction (NR) causes small for gestational age (SGA) offspring, which are at higher risk for accelerated postnatal growth and developing insulin resistance in adulthood. Skeletal muscle is essential for whole-body glucose metabolism, as 80% of insulin-mediated glucose uptake occurs in this tissue. Maternal NR can alter fetal skeletal muscle mass, expression of glucose transporters
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Pattern of postruminal administration of l-tryptophan affects blood serotonin in cattle Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-21 E.E.L. Valente; J.L. Klotz; G. Ahn; D.L. Harmon
Serotonin (5-HT) has many important functions in both central and peripheral nervous systems. Although it has been demonstrated that manipulation of serotonin metabolism is possible in many species, there is limited information about l-tryptophan (TRP), a serotonin precursor, in cattle, and these provide conflicting results. Furthermore, there is no study evaluating how different patterns of intra-abomasal
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A randomized cross-over trial assessing salivary and urinary cortisol concentrations after alfaxalone and propofol administration in healthy cats Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-10 I.D. Yozova; H. Sano; K. Weidgraaf; E.J. Candy; J.F. Cockrem
The aim of this study was to assess the effects of commonly used anaesthetics alfaxalone and propofol on salivary and urinary cortisol in healthy cats. Fifteen male castrated research-purposed cats received randomly intravenous continuous rate infusions of 8 mg/kg/h of alfaxalone, 12 mg/kg/h of propofol and 2 ml/kg/h of Lactated Ringer's solution for 30 min, with intervals of 6 days between treatments
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Differentiation of canine adipose mesenchymal stem cells into insulin-producing cells: comparison of different culture medium compositions Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-17 B.O.S. Camara; N.M. Ocarino; B.M. Bertassoli; C. Malm; F.R. Araújo; A.M.S. Reis; E.C. Jorge; E.G.L. Alves; R. Serakides
The aim of this study was to differentiate canine adipose-derived mesenchymal stem cells (ADMSCs) into insulin-producing cells by using culture media with different compositions to determine the most efficient media. Stem cells isolated from the fat tissues close to the bitch uterus were distributed into 6 groups: (1) Dulbecco's modified Eagle medium (DMEM)–high glucose (HG), β-mercaptoethanol, and
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5-Hydroxytryptophan strongly stimulates serotonin synthesis in Holstein steers Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-12 E.E.L. Valente; J.L. Klotz; D.L. Harmon
Although serotonin has been extensively studied in many species, there is a lack of information in ruminants, and no research has been evaluated if its precursor, 5-hydroxytryptophan (5-HTP), administered into the abomasum may be used as a means to manipulate serotonin metabolism. Thus, the objective of this study was to evaluate if intra-abomasal infusion of 5-HTP increases circulating serotonin in
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Oxytocin receptor expression in stallion testes and epididymides Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-12 Y. Jung; M. Yoon
Endocrine, paracrine, and autocrine factors orchestrate the development and physiology of the stallion reproductive system. Oxytocin (OXT) is one of the critical endocrine, paracrine, and autocrine factors for the male reproductive system. Previous studies have investigated OXT receptor (OXTR) expression in testes and epididymides, including humans, marmosets, macaques, swine, and sheep. This study
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Deep small RNA-Seq reveals microRNAs expression profiles in lactating mammary gland of 2 sheep breeds with different milk performance Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-13 Z.Y. Hao; J.Q. Wang; Y.L. Luo; X. Liu; S.B. Li; M.L. Zhao; X.Y. Jin; J.Y. Shen; N. Ke; Y.Z. Song; L.R. Qiao
Micro ribonucleic acid (miRNA) is a type of noncoding RNA, and it has been revealed to play important roles in the activity of the mammary gland (MG) in some species. However, the function of miRNAs in MG of sheep is poorly understood. In the study, Gansu Alpine Merino (GAM; n = 9) and Small-tailed Han sheep (STH; n = 9) with different milk production traits were investigated. Microstructures and the
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HSP70 inhibits pig pituitary gonadotrophin synthesis and secretion by regulating the corticotropin-releasing hormone signaling pathway and targeting SMAD3 Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-01 G. Xu; J. Li; D. Zhang; T. Su; X. Li; S. Cui
High levels or long periods of stress have been shown to negatively impact cell homeostasis, including with respect to abnormalities in domestic animal reproduction, which are typically activated through the hypothalamus–pituitary–adrenal axis, in which corticotropin-releasing hormone (CRH) and heat shock protein 70 (HSP70) are involved. In addition, CRH has been reported to inhibit pituitary gonadotrophin
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Urinary vanillylmandelic acid:creatinine ratio in dogs with pheochromocytoma Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-04 E.A. Soler Arias; R.H. Trigo; D.D. Miceli; P.N. Vidal; M.F. Hernandez Blanco; V.A. Castillo
Pheochromocytoma diagnosis in dogs is challenging because biochemical tests are not always available. In humans, urinary vanillylmandelic acid (VMA) is part of a pheochromocytoma biochemical diagnostic profile, whereas its diagnostic accuracy is currently unknown in dogs with pheochromocytoma. Prospectively, VMA was determined by HPLC and expressed as the ratio with respect to urinary creatinine (VMA:C)
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Serum concentration of mineralocorticoids, glucocorticoids, and sex steroids in peripartum bitches Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-09-04 C. Milani; A. Rota; U. Olsson; A. Paganotto; B.S. Holst
The aim of the work was to describe the profile of steroid hormones in the peripartum period of the bitch. Twenty-five healthy pregnant bitches presented for pregnancy monitoring and parturition assistance were included in the study. A blood sample was collected for routine progesterone assay, and serum was stored at −20°C. The day of parturition and the number of delivered puppies were registered
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Effects of nutrient restriction and melatonin supplementation from mid-to-late gestation on maternal and fetal small intestinal carbohydrase activities in sheep. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-21 R J Trotta,C O Lemley,K A Vonnahme,K C Swanson
The objective of this experiment was to evaluate the effects of nutrient restriction and melatonin supplementation during mid-to-late gestation on maternal and fetal small intestinal carbohydrase activities in sheep. Ewes were randomly assigned to one of 4 dietary treatments arranged in a 2 × 2 factorial design. Ewes were fed to provide 100% (adequate; ADQ) or 60% (restricted; RES) of nutrient recommendations
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Free and bound cortisol, corticosterone, and metabolic adaptations during the early inflammatory response to an intramammary lipopolysaccharide challenge in dairy cows. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-18 J J Gross,A-C Schwinn,R M Bruckmaier
Glucocorticoids, particularly cortisol and corticosterone, are key homeostatic regulators during metabolic and endocrine adaptations including inflammatory responses. Besides the established response of total cortisol (TC) concentrations during inflammatory processes in dairy cows, we investigated changes of corticosterone, free cortisol (FC), and serum albumin as the main protein of unspecific cortisol
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Transoperative glycemia in pets: validating old ones, and presenting lip mucosa as new sampling site. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-17 P B Costa,M L Ricarti,C A A Augustavo,L S Santos,L Z Crivellenti,S Borin-Crivellenti
The aim of our study was to investigate the viability and validity of blood sampling from the upper lip mucosa in healthy dogs and cats for monitoring transoperative glycemia and compare the results with those obtained from samples taken from previously described blood sampling sites for determination of glycemia using a glucose meter. Blood glucose (BG) levels were determined in samples taken from
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Association of GH polymorphisms with growth traits in buffaloes. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-17 S M El-Komy,A A Saleh,R M Abd El-Aziz,M A El-Magd
Members of the somatotrophic axis, especially GH and IGF1, are essential for growth. The association between GH polymorphisms and growth traits was numerously studied in cattle; however, no data are available for such association studies in buffalo. Therefore, this study was conducted to screen for polymorphisms in the GH gene and to study their putative association with growth traits in 200 Egyptian
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The KMT2A gene: mRNA differential expression in the ovary and a novel 13-nt nucleotide sequence variant associated with litter size in cashmere goats. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-14 Q Tang,Y Zhang,Y Yang,H Hu,X Lan,C Pan
A genome-wide association study had shown that lysine methyltransferase 2A (KMT2A), which encodes the histone 3 lysine 4 methyltransferase and reportedly can regulate gametogenesis, steroidogenesis, and development as well as other biological processes, is a potential candidate gene influencing litter size in the dairy goat, suggesting its key function in animal reproduction. Here, we aimed to explore
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Effect of dietary l-arginine of broiler breeder hens on embryonic development, apparent metabolism, and immunity of offspring. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-11 F Li,H Ning,X Duan,Z Chen,L Xu
This study investigated the effects of supplemented l-arginine (l-Arg) in broiler breeder hens' diets on the embryonic development and physiological changes of offspring during the hatching period. A total of 480 35-wk-old healthy female Arbor Acres broiler breeders were randomly divided into 6 groups and fed a corn and soybean meal diet with 6 digestible Arg levels (0.96%, 1.16%, 1.35%, 1.55%, 1.74%
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Plasma prolactin, thyroid-stimulating hormone, melanocyte-stimulating hormone, and adrenocorticotropin responses to thyrotropin-releasing hormone in mares treated with detomidine and butorphanol. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-07 E L Oberhaus,D L Thompson,L E Kerrigan,A M Chapman
Stress or excitement is a concern when performing endocrine tests on fractious horses. Sedation may be a solution; however, perturbation of test results may preclude useful information. Thyrotropin-releasing hormone (TRH) is a known stimulator of prolactin, thyroid-stimulating hormone (TSH), melanocyte-stimulating hormone (MSH), and ACTH. Thyrotropin-releasing hormone–induced ACTH is a diagnostic tool
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The expression of androstenone receptor (OR7D4) in vomeronasal organ and olfactory epithelium of horses. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-06 Y Choi,M Yoon
Androstenone is the first mammalian steroidal pheromone to be identified. Pheromones are chemicals that animals use to communicate within a species. Pheromone detections are related to vomeronasal organ (VNO) and olfactory epithelium (OE) in mammals. Olfactory Receptor Family 7 Subfamily D Member 4 (OR7D4) is an odorant receptor that responds to androstenone. Several studies indicated that spray with
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Cyclooxygenase 2 messenger RNA levels in canine follicular cells: interrelationship with GDF-9, BMP-15, and progesterone. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-06 M De Los Reyes,J Palomino,A Araujo,J Flores,G Ramirez,V H Parraguez,K Aspee
Cyclooxygenase 2 (COX-2) encoded by the Cox-2 gene within the periovulatory follicles is a critical mediator of oocyte development. Growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15) participate in the modulation of certain target genes in the ovary, possibly influencing the Cox-2 gene expression. However, this relationship has not been characterized in canines. This
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Effects of melatonin administration to cashmere goats on cashmere production and hair follicle characteristics in two consecutive cashmere growth cycles. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-04 C H Yang,C H Duan,Z Y Wu,Y Li,Y Y Luan,X J Fu,C X Zhang,W Zhang
The objective of the study was to determine the long-term effects of melatonin treatment on cashmere production and hair follicle populations in cashmere goats and their activity in two consecutive cashmere growth cycles. Twenty-four female Inner Mongolian Cashmere goats were randomly allocated to two groups (n = 12), one of which received melatonin implants, the other being an untreated control group
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Amyloidogenesis of feline amylin and plasma levels in cats with diabetes mellitus or pancreatitis. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-08-01 L Jotha-Mattos,A B Vieira,M da S M Castelo,A S de M Queiroz,H J M de Souza,N X de Alencar,L M T R Lima
Amylin is a pancreatic hormone cosecreted along with insulin and involved in pancreatic amyloidosis and β-cell apoptosis in diabetic cats and humans. Amylin is usually elevated in early stages of type 2 diabetes but recently was found to be increased in acute and chronic pancreatitis in humans. Currently, there are little data about feline amylin propensity to fibrillate and no information on circulating
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Effects of pituitary pars intermedia dysfunction and Prascend (pergolide tablets) treatment on endocrine and immune function in horses. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-29 A B Miller,A T Loynachan,H M Bush,K A Hart,V D Barker,A G Campana-Emard,S T Grubbs,A A Adams
It remains unclear how pituitary pars intermedia dysfunction (PPID) and pergolide treatment (Prascend [pergolide tablets]) affect endocrine and immune function in horses. To evaluate these effects, blood was collected regularly from 28 university-owned horses (10 Non-PPID, 9 PPID control [PC], and 9 PPID treatment [PT]) over approximately 15 mo. Pergolide treatment was initiated after Day 0 collections
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Effects of insulin on IGF-1 receptors in equine lamellar tissue in vitro. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-29 S Rahnama,R Spence,N Vathsangam,C L Baskerville,S R Bailey,M A de Laat,S T Anderson,C C Pollitt,M N Sillence
Although it is understood that equine endocrinopathic laminitis can be triggered by high concentrations of insulin, it is unclear whether this represents a direct action on lamellar tissue via insulin receptors (InsR), an interaction with IGF-1 receptors (IGF-1R), or some other, indirect action. This uncertainty is because of the reported scarcity of InsR in lamellar tissue and the low affinity of
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Neurokinin 3 receptor-selective agonist, senktide, decreases core temperature in Japanese Black cattle. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-28 S Nakamura,M Miwa,Y Morita,S Ohkura,T Yamamura,Y Wakabayashi,S Matsuyama
Heat stress disrupts reproductive function in cattle. In summer, high ambient temperature and humidity elevate core body temperature, which is considered to be detrimental to reproductive abilities in cattle. Neurokinin B (NKB) is a factor that generates pulsatile GnRH and subsequent LH secretion in mammals. Recent studies have reported that NKB-neurokinin 3 receptor (NK3R) signaling is associated
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Involvement of progesterone and estrogen receptors in the ram sperm acrosome reaction. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-24 S Gimeno-Martos,M Santorromán-Nuez,J A Cebrián-Pérez,T Muiño-Blanco,R Pérez-Pé,A Casao
The steroid hormones 17-β estradiol (E2) and progesterone (P4) can regulate capacitation, hyperactive motility, and the acrosome reaction (AR) during the sperm transit through the female tract. Moreover, exogenous P4 and E2 can induce the AR in ovine spermatozoa, and progesterone receptor (PR) and estrogen receptors (ERα and ERβ) are present in these cells. Thus, to investigate whether the effects
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Effects of feeding a moderate- or high-energy close-up diet to cows on response of newborn calves to milk replacer feeding and intravenous injection of glucagon-like peptide 1. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-23 Y Inabu,J Haisan,M Oba,T Sugino
In this study, we investigated the effects of feeding a moderate- or high-energy close-up diet to close-up cows on response of newborn calves to intravenously (i.v.) injected glucagon-like peptide 1 (GLP-1). Newborn Holstein heifer calves (n = 37) from cows fed with a moderate-energy [M, 1.54 Mcal/kg of dry matter (DM) NEl; 14% starch; n = 17] or high-energy (H, 1.63 Mcal/kg of DM NEl; 26% starch;
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The in vitro effects of melatonin and Cry gene on the secretion of estradiol from camel ovarian granulosa cells. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-22 Zhao Shu-Qin,Zhang Yong,Gao Yuan,Yang Xiao-Pu,Yang Zhen,Yang Zhi-Jie
Bactrian camel as endemic economic species to the Northwest of China, its seasonal reproduction severely limits litter rates. In addition to melatonin, seasonal reproduction of animals is also regulated by the biological clock, but the specific molecular mechanism is not clear. To investigate the effects of melatonin and Cryptochrome (Cry) genes on seasonal reproduction, they were placed in ovarian
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Implications of growth rates and compensatory growth on puberty attainment in Nellore heifers. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-20 A A Miszura,M V C Ferraz,R C Cardoso,D M Polizel,G B Oliveira,J P R Barroso,L G M Gobato,G P Nogueira,J S Biava,E M Ferreira,A V Pires
This study investigated the effects of growth rates and compensatory growth on puberty attainment in Nellore heifers. Nellore heifers (n = 120), weaned at 8 ± 0.75 mo of age, were blocked by sire and BW (180 ± 8.6 kg) and assigned randomly to receive 1 of 4 treatments over a 10-mo period. Treatments included ad libitum feeding (high gain, HG), feed intake to gain 0.6 kg/d (medium gain, MG), restricted
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The role of protein restriction and interaction with antibiotics in the regulation of compensatory growth in pigs: growth performance, serum hormone concentrations, and messenger RNA levels in component tissues of the endocrine growth axis. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-20 D Ju,T Teng,G Bai,H Fu,S Qiu,X Zhao,Y Sun,B Shi
The present study investigated the effects of protein restriction and antibiotics on the hypothalamus–pituitary–liver growth axis during the compensatory growth of growing and finishing pigs. Growth performance, serum hormones, and messenger RNA (mRNA) levels of hormones and their receptors in growth axis tissues were recorded for analyses. A total of 64 piglets (large white × Landrace × Duroc cross)
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Evaluation of a flash glucose monitoring system in dogs with diabetic ketoacidosis. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-18 D D Silva,G R M Cecci,G Biz,F N Chiaro,M S Zanutto
The flash glucose monitoring system (FGMS) Freestyle Libre provides estimates of blood glucose by constantly measuring the glucose concentration of the interstitial fluid through a sensor inserted in the subcutaneous space. The aim of this study was to evaluate the applicability and accuracy of the FGMS in dogs with diabetic ketoacidosis (DKA). Seven dogs with DKA examined at the Veterinary Hospital
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Messenger RNA expression and localization of xenin in the gastrointestinal tract in sheep. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-18 T Onaga,A Sakai,M Kajita,H Fukuda,Y Yasui,H Hayashi
The present study aimed to determine the primary sequence of ovine xenin and clarify the mRNA expression and peptide localization of xenin in the gastrointestinal tract in sheep. The colocalization of xenin and glucose-dependent insulinotropic polypeptide was also compared in the antrum and duodenum. Analysis of the nucleotide sequence of ovine xenin revealed a high degree (97.9%) of sequence homology
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Peripheral serotonin regulates glucose and insulin metabolism in Holstein dairy calves. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-09 S L Field,M G Marrero,B Dado-Senn,A L Skibiel,P M Ramos,T L Scheffler,J Laporta
Peripheral serotonin regulates energy metabolism in several mammalian species, however, the potential contribution of serotonergic mechanisms as metabolic and endocrine regulators in growing dairy calves remain unexplored. Objectives were to characterize the role of serotonin in glucose and insulin metabolism in dairy calves with increased serotonin bioavailability. Milk replacer was supplemented with
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Wilms' tumor (WT1) (±KTS) variants decreases the progesterone secretion of bovine ovarian theca cells. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-07 X Wang,K Meng,Y Wang,Y Zhao,F Lin,X Liu,Y Zhang,F Quan
Wilms' tumor gene WT1 encodes a nuclear transcriptional factor, which has been shown to regulate granulosa cell steroidogenesis in bovine; however, it is not known whether the functions of theca cells are regulated by WT1. Here, we determined the effects of this gene on theca cell proliferation, apoptosis, and steroidogenesis in vitro. In cultured bovine theca cells, the downregulation of WT1 increased
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Interrelationships between kisspeptin and FSH in control of porcine ovarian cell functions. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-06 Z Fabová,A V Sirotkin
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Metoclopramide induces preparturient, low-level hyperprolactinemia to increase milk production in primiparous sows. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-07-03 A T Mathews,C M Banks,J F Trott,R D Sainz,C Farmer,I I Pendergast,R C Hovey
Inadequate milk production by sows often limits the growth of piglets. A successful lactation requires prolactin (PRL)-induced differentiation of the alveolar epithelium within the mammary glands of sows between days 90–110 of gestation. We hypothesized that induction of late gestational hyperprolactinemia in primiparous sows by oral administration of the dopamine antagonist metoclopramide (MET) would
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Exogenous progestogens differentially alter gene expression of immature cumulus-oocyte complexes in sheep. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-06-29 G M Bragança,R I T P Batista,J M G Souza-Fabjan,V A P Alfradique,E K N Arashiro,P H N Pinto,J D R Santos,L S A Camargo,A Menchaca,J F da Fonseca,F Z Brandão
This study evaluated the role of progesterone (P4) and medroxyprogesterone acetate (MAP) on the molecular status of immature cumulus–oocyte complexes (COCs) and the implications for oocyte quality in sheep. The number of viable COCs per ewe and the rate of COCs screened for developmental competence by brilliant cresyl blue positive (BCB+) were similar (P > 0.05), respectively, across treatments (P4:
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Melatonin improves the motility and DNA integrity of frozen-thawed ram spermatozoa likely via suppression of mitochondrial superoxide production. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-06-29 K R Pool,J P Rickard,S P de Graaf
The ability of the neurohormone melatonin to ameliorate cryopreservation-induced damage to spermatozoa has been demonstrated in several domestic species. However, it is unclear how these protective effects are conferred, with improvements in sperm quality ambiguously attributed to the general antioxidant activity of melatonin. To further investigate this phenomenon, ram spermatozoa were diluted in
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Local sex steroid hormone milieu in the bovine oviduct ipsilateral and contralateral to preovulatory follicle or corpus luteum during the periovulatory phase. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-06-26 K Hazano,S Haneda,M Kayano,M Matsui
Estradiol-17β (E2) and progesterone (P4) regulate oviductal functions, providing a suitable environment for the transport and maturation of gametes, fertilization, and embryonic development. In addition to the E2 and P4 nuclear receptors, estrogen receptor (ESR) α and β, nuclear progesterone receptor (PGR), nongenomic mechanisms through G protein-coupled estrogen receptor (GPER1), and progesterone
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Induced prostaglandin release alters steroid concentrations but not pregnancy survival in cows. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-06-23 S T Reese,G A Franco,K M Schubach,A P Brandao,S M West,R F Cooke,R C Cardoso,G L Williams,K G Pohler
Embryonic mortality (EM) is a major factor limiting reproductive efficiency in cattle, and despite negative connotations related to reproductive performance, prostaglandin F2α (PGF2α) is capable of being released by the uterus by Day 30 of gestation. Therefore, the objective was to evaluate differences in PGF2α release after an oxytocin challenge between cows with high circulating concentrations of
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MiR-33a inhibits the adipogenic differentiation of ovine adipose-derived stromal vascular fraction cells by targeting SIRT6. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-06-18 Q Wang,Y Pan,B Zhao,L Qiao,J Liu,Y Liang,W Liu
Adipose tissue is important for the regulation of energy balance through its metabolic, cellular, and endocrine functions. Furthermore, the excessive storage of subcutaneous fat can seriously affect the health and carcass traits of domestic animals. Stromal vascular fraction (SVF) cell adipogenic differentiation increases the number of differentiated adipocytes and plays a role in lipid deposition
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The role of liver metabolism in compensatory-growth piglets induced by protein restriction and subsequent protein realimentation. Domest. Anim. Endocrinol. (IF 1.778) Pub Date : 2020-06-17 M Y Zhang,P Hu,D Feng,Y Z Zhu,Q Shi,J Wang,W Y Zhu
The aim of this work was to study the role of hepatic metabolism of compensatory growth in piglets induced by protein restriction and subsequent protein realimentation. Thirty-six weaned piglets were randomly distributed in a control group and a treatment group. The control group piglets were fed with a normal protein level diet (18.83% CP) for the entire experimental period (day 1–28). The treatment