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Monitoring Staphylococcus aureus nasal colonization murine model using a bioluminescent methicillin-resistant S. aureus (MRSA) Lab. Anim. (IF 2.4) Pub Date : 2024-03-10 Juliana G da Silva, Juliana PC Boechat, Bruno DJ Silva, Rodrigo Müller, José PM Senna
Staphylococcus aureus nasal carriage is considered a risk factor for infections, and the development of nasal decolonization strategies is highly relevant. Despite they are not naturally colonized by Staphylococcus, mice are a good model for S. aureus nasal colonization. Murine models are easy to manipulate, and inter-laboratory reproducibility makes them suitable for nasal colonization studies. Strategies
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XVII SECAL CONGRESS Santiago de Compostela (Spain), 14–17 November 2023 Lab. Anim. (IF 2.4) Pub Date : 2024-03-06
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Bibliometric analysis on cannibalism/infanticide and maternal aggression towards pups in laboratory rodents Lab. Anim. (IF 2.4) Pub Date : 2024-02-14 José C Bravo, Lierni Ugartemendia, Arko Barman, Ana B Rodríguez, José A Pariente, Rafael Bravo
Animal welfare has evolved during the past decades to improve not only the quality of life of laboratory rodents but also the quality and reproducibility of scientific investigations. Bibliometric analysis has become an important tool to complete the current knowledge with academic databases. Our objective was to investigate whether scientific research on cannibalism/infanticide is connected with maternal
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Urinary bladder catheterisation of female pigs: Influence of bladder content and Escherichia coli urinary tract infection on procedural outcome Lab. Anim. (IF 2.4) Pub Date : 2024-02-09 Kristian Stærk, Louise Langhorn, Bo Halle, Thomas Emil Andersen
Catheterisation of the urinary bladder is needed in many types of human disease models in pigs. Based on our extensive experience with the pig as an infection model, we here demonstrate an approach of catheterising domestic pigs (40 attempts) and Göttingen minipigs (10 attempts) using a blinded method, that is, without speculums or videoscopes to visualise the urethral opening. The procedure was tested
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Validation of computed tomography as a diagnostic tool in guinea pigs with non-alcoholic fatty liver disease. Lab. Anim. (IF 2.4) Pub Date : 2023-11-24 Kristine Lintrup,David Højland Ipsen,Josephine Skat-Rørdam,Jens Lykkesfeldt,Pernille Tveden-Nyborg,Lene Elisabeth Buelund
Non-alcoholic fatty liver disease (NAFLD) and subsequent steatohepatitis (NASH) is the most common cause of liver disease and liver transplantation in humans. Affecting millions of patients worldwide, diagnosis relies on a biopsy, not without risk to the patient, and emphasises the need for improved diagnostic measures to determine and monitor disease progression. Despite intensive research, approved
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Software for animal randomization: A tool for increasing the reproducibility of science. Lab. Anim. (IF 2.4) Pub Date : 2023-10-28 Liana Monteiro da Fonseca Cardoso,Natiele Carla da Silva Ferreira,Matheus de Araripe Lopes Correa,Sérgio Alves da Silva,Luiz Anastacio Alves
Poorly designed preclinical studies may compromise human health due to erroneous conclusions regarding treatment effects in addition to contributing to experimental irreproducibility and wasted resources. Randomization is one of the crucial steps to enhance scientific rigor and is a commonly recognized bias-reducing instrument that increases the reliability and reproduction of studies involving animals
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Announcement of the V SPCAL Congress. Lab. Anim. (IF 2.4) Pub Date : 2023-10-01 M J Castelhano-Carlos
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Twelve years after the ARRIVE guidelines: Animal research has not yet arrived at high standards. Lab. Anim. (IF 2.4) Pub Date : 2023-09-20 Junmin Song,Marco Solmi,Andre F Carvalho,Jae Il Shin,John Pa Ioannidis
The reproducibility crisis across animal studies jeopardizes the credibility of the main findings derived from animal research, even though these findings are critical for informing human studies. To clarify and improve transparency among animal studies, the ARRIVE reporting guidelines were first announced in 2010 and upgraded to version 2.0 in 2020. However, compliance with and awareness of those
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Improving rat welfare through the development of a peribulbar anaesthesia technique for ophthalmic procedures: A preliminary study. Lab. Anim. (IF 2.4) Pub Date : 2023-09-20 Ady Eliav,Ron Ofri,Kelsey Brust,Yishai Kushnir,Yael Shilo-Benjamini
Rats are a commonly used animal model for the study of the pathogenesis and novel treatments of glaucoma, which is induced experimentally using invasive, painful procedures. Peribulbar anaesthesia (PBA) is frequently used in people and domestic animals prior to ophthalmic surgeries to provide excellent perioperative analgesia. Our goal was to develop a PBA technique adapted to rat anatomy, improving
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Comparing United States and European Union academic animal programs: Finances. Lab. Anim. (IF 2.4) Pub Date : 2023-09-20 Patricia Preisig,James D Macy,Jann Hau
The Yale Animal Resource Cost and Benchmarking survey, conducted in United States (US) academic animal research/resource centres (ARC), was modified to capture similar information in European Union (EU) (including the non-EU countries Switzerland and the United Kingdom) academic ARCs, who are members of the League of European Research Universities (LERU). Participating institutions came from Denmark
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Comparing United States and European Union academic animal programs: Organization, operation, and services offered. Lab. Anim. (IF 2.4) Pub Date : 2023-09-20 Patricia Preisig,James D Macy,Jann Hau
The Yale Animal Resource Cost and Benchmarking survey©, conducted in US academic Animal Research/Resource Centers (ARC), was modified to capture similar thematic information in European Union (EU; including the non-EU countries Switzerland and the UK) academic ARCs, which are members of the League of European Research Universities (LERU). Participating institutions came from Denmark, England, Finland
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Rats prefer condensed milk to strawberry jam - a new possibility for voluntary oral drug administration. Lab. Anim. (IF 2.4) Pub Date : 2023-09-15 Mariana Ferreira-Duarte,Igor Moreira Lopes,Manuela Morato,Margarida Duarte-Araújo
Voluntary oral drug administration using sweet substances promotes rodents' therapeutic compliance while reducing stress induced by forced drug administration. We aimed to test whether rats would willingly eat strawberry jam or condensed milk from a syringe, and which one they would prefer. Our results show that rats prefer condensed milk, demonstrating its potential as a vehicle for the voluntary
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Eugenol as anesthetic for Cnesterodon decemmaculatus (Cyprinodontiformes, Poeciliidae). Lab. Anim. (IF 2.4) Pub Date : 2023-09-15 Maria C Vercellini,Ramiro Rearte,Luca di Cesare,Miguel A Ayala,Martin M Montes
Anesthetics are commonly used in fish for surgery and to facilitate capture, handling and transport in aquaculture and experimental procedures. In research, the selection of the anesthetic depends on its properties and on the recovery time. Eugenol has been pointed out as an effective anesthetic for fish, alternative to traditional drugs. Although Cnesterodon decemmaculatus is widely used as a model
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Investigation of circulating infectious agents in experimental Beagle dogs of a production colony and three research facilities in China from June 2021 to May 2022. Lab. Anim. (IF 2.4) Pub Date : 2023-09-13 Yue Zhao,Panlong Wang,Xueting Qu,Kunpeng Yuan,Suzhen Zhu,Sen Wang,Qingdong Luan,Hao Zhou,Yue Yin,Zijing Zhao,Yongjuan Gao,Shuzhen Chen,Yanjing Lu,Jianlin Wang,Yanbo Yin
To understand the epizootiologic characteristics of pathogens and opportunistic infections in one Beagle dog production colony and three research facilities, viruses and mycoplasma were detected in 1777 samples collected from Beagle dogs in China by polymerase chain reaction/reverse transcription polymerase chain reaction, and bacteria were isolated and identified by 16S rRNA sequence analysis. In
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Guidelines for the establishment and functioning of Animal Ethics Commitees (Institutional Animal Care and Use Committees) in Africa. Lab. Anim. (IF 2.4) Pub Date : 2023-09-06 Bert J Mohr,Ouajdi Souilem,Sohair R Fahmy,Francis Fakoya,Khadiga Gaafar,Josiah T Kantiyok,Farida Khammar,Sarrah Mbarek,Lawrence Mugisha,Hany Sleem,Alemayehu Toma,Maricél van Rooyen,Henry Zakumumpa,David I Lewis
Animals are used for scientific purposes across Africa to benefit humans, animals or the environment. Nonetheless, ethical and regulatory oversight remains limited in many parts of the continent. To strengthen this governance framework, the Pan-African Network for Laboratory Animal Science and Ethics brought together experts from 12 African countries to create an Africa-centric practical guide to facilitate
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Clinical efficacy of buprenorphine after oral dosing in rats undergoing major surgery. Lab. Anim. (IF 2.4) Pub Date : 2023-09-05 Einar Sjaastad Nordén,Ioanni Veras,Prakash Yadav,Kari Løken,Hilde Dishington,Christian Thorstensen,Ivar Sjaastad,Henrik Rasmussen
Serum corticosterone, serum buprenorphine, body weight change, consumption of food and water and behaviour-based pain assessment were measured in catheterised and non-catheterised male Wistar rats undergoing myocardial infarct (MI) surgery under general anaesthesia following buprenorphine dosing by subcutaneous (Bup-SC, 0.05 mg/kg) and oral (Bup-O, 0.4 mg/kg) routes. Buprenorphine was dosed subcutaneously
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Influence of general anaesthesia on circulating biomarkers of glucose metabolism in pigs. Lab. Anim. (IF 2.4) Pub Date : 2023-08-30 Berit Ø Christoffersen,Cathrine J Bundgaard,Karina R Hjøllund,Johannes Josef Fels,Kirstine K Boll,Mille K Lyhne,Lisbeth H Olsen
Pigs are widely used in metabolic research with procedures often requiring general anaesthesia. The aim was to investigate the effect of four different anaesthetic protocols: 1) isoflurane inhalation, 2) propofol infusion, 3) a mixture of tiletamine, zolazepam, medetomidine, ketamine and butorphanol (TZMKB)) and 4) ketamine combined with midazolam and xylazine (KMX)) on selected biomarkers during basal
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Nomenclature for standardized designation of diploid genotypes in genetically modified laboratory animals. Lab. Anim. (IF 2.4) Pub Date : 2023-08-01 Peter Dobrowolski,Thorsten Buch,Stefan Nagel-Riedasch
Information about the diploid genotype of a gene-modified or mutant laboratory animal is essential for breeding and experimental planning. It is also required for the exchange of animals between different research groups or for communication with professional genotyping service providers. While there are detailed, standardized rules for creating an allele name of a genome modification or mutation,
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Media training: 'Communicating your animal research', SECAL-EARA. Lab. Anim. (IF 2.4) Pub Date : 2023-08-01
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Expression of Concern: "Advances in research on the biology of the desert rodent Gerbillus tarabuli: a review". Lab. Anim. (IF 2.4) Pub Date : 2023-07-20
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Case report: An adverse response to cyclosporin A treatment in BALB/cJ mice. Lab. Anim. (IF 2.4) Pub Date : 2023-07-03 Vaughn Ticar,Allison Tschirley,Michelle Wilson,Anene du Plessis,Merilyn Hibma
Cyclosporin A (CsA) is an immunosuppressive drug that has been widely used in mice at a range of doses from 10 to 200 mg/kg. Our group carried out an experiment in 2016 where we delivered 75 mg/kg CsA (NeoralTM) to BALB/cJ mice by oral gavage to enable wart formation in mice, which was moderately well-tolerated. We recently commenced another study using the same dose and route of delivery of CsA in
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A minimally invasive bronchoscopic approach for direct delivery to murine airways and application to models of pulmonary infection. Lab. Anim. (IF 2.4) Pub Date : 2023-06-29 Karen Schelde,Julie Rosenjack,Claire Sonneborn,Anjum Jafri,Michael Kavran,Sarah Brumbaugh,Arne Rietsch,Rebecca J Darrah,Craig A Hodges,Christopher A Flask,Thomas J Kelley,Mitchell L Drumm
The laboratory mouse is used extensively for human disease modeling and preclinical therapeutic testing for efficacy, biodistribution, and toxicity. The variety of murine models available, and the ability to create new ones, eclipses all other species, but the size of mice and their organs create challenges for many in vivo studies. For pulmonary research, improved methods to access murine airways
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Harmonisation of education, training and continuing professional development for laboratory animal caretakers, technicians and technologists: Report of the FELASA-EFAT Working Group. Lab. Anim. (IF 2.4) Pub Date : 2023-06-19 Klas Sp Abelson,Charlie Chambers,Teresa De La Cueva,Glyn Fisher,Penny Hawkins,Vasileios Ntafis,Paul F Pohlig,T Pim Rooymans,Ana I Santos
Competent, confident and caring laboratory animal caretakers, technicians and technologists (LAS staff) are vital for good animal welfare, high-quality science and a secure Culture of Care. This requires high-quality education, training, supervision and continuing professional development (CPD) of LAS staff. However, there is a lack of harmonisation regarding how this education and training is conducted
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A new book of 3000 pages edited by SECAL for the LAS education and training on an interactive e-learning platform. Lab. Anim. (IF 2.4) Pub Date : 2023-06-01
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Supporting advancement of lab animal welfare and scientific integrity in developing countries: ACURET Cage Consortium (ACCON) Project. Lab. Anim. (IF 2.4) Pub Date : 2023-06-01 Francis-Adelade Go Fakoya
Research involving animals remains an essential tool to increase our understanding of how human and animal bodies work; how diseases affect them and the safety assessment of chemicals, such as pesticides, for their possible effects on human health or the environment; and how diseases can be prevented or treated via developing and testing medicines and vaccines for humans or animals. To achieve high
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The importance of methodological detail and conceptual context when presenting laboratory animal science education tools: The authors' reply. Lab. Anim. (IF 2.4) Pub Date : 2023-05-19 Eliana M Cicale,Verónica Casanova,Eduardo Caturini,Marianela Ceol Retamal,María C Greco,Sofía Gimenez,Julián E Gulin
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The importance of methodological detail and conceptual context when presenting laboratory animal science education tools. Lab. Anim. (IF 2.4) Pub Date : 2023-05-19 Andreia Costa,I Anna S Olsson
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Mouse isoflurane anesthesia using the drop method Lab. Anim. (IF 2.4) Pub Date : 2023-05-05 Maya J Bodnar, Anna S Ratuski, Daniel M Weary
Anesthesia with isoflurane prior to carbon dioxide euthanasia is recommended as a refinement, but vaporizer access can be limited. An alternative to vaporizers is the ‘drop’ method, introducing a f...
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Non-surgical external jugular vein catheterization using an ear vein access in piglets Lab. Anim. (IF 2.4) Pub Date : 2023-04-19 S.K. Ringer, A. Schmid, M. Weiss, S. Ohlerth, N. Spielmann, N.G. Clausen
The objective of this study was to investigate the feasibility of external jugular vein catheterization through an ear vein in piglets. Forty-six sevoflurane-midazolam anaesthetized piglets were in...
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Optimization of overhead enclosure monitoring in juvenile male Dunkin Hartley guinea pigs (Cavia porcellus) Lab. Anim. (IF 2.4) Pub Date : 2023-04-18 Joel E Helbling, Alexa P Spittler, Miranda J Sadar, Kelly S Santangelo
Overhead enclosure monitoring provides objective quantitative mobility measurements for animals undergoing open-field testing. Notably, protocols for testing optimization have been minimally establ...
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Pathologic copulatory lock in a genetically engineered laboratory mouse breeding pair Lab. Anim. (IF 2.4) Pub Date : 2023-04-18 Glory Leung, Rodolfo Ricart-Arbona, Sebastien Monette, Neil S Lipman
A breeding pair of genetically engineered laboratory mice (Mus musculus) presented in apparent copulatory lock (coital tie). After anesthetizing the animals, gentle traction was used to separate th...
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Refinement of systemic guinea pig deafening in hearing research: Sensorineural hearing loss induced by co-administration of kanamycin and furosemide via the leg veins Lab. Anim. (IF 2.4) Pub Date : 2023-04-18 Wiebke Behrends, Daniel Ahrens, Jens P. Bankstahl, Karl-Heinz Esser, Gerrit Paasche, Thomas Lenarz, Verena Scheper
Auditory disabilities have a large impact on the human population worldwide. Research into understanding and treating hearing disabilities has increased significantly in recent years. One of the mo...
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Tramadol/paracetamol treatment attenuates the development of collagen antibody-induced arthritis and interferes with prednisolone treatment in mice Lab. Anim. (IF 2.4) Pub Date : 2023-04-17 Sanne Kroos, Mahmoud Halima, Jan Kroon, Diane van der Woude, Onno C Meijer, Maarten D van de Wal, Peternella S Verhave, Marcel JM Schaaf, René EM Toes, Arieke SB Kampstra
The collagen antibody-induced arthritis (CAIA) model is highly effective in inducing arthritis, making it an attractive model for screening therapeutic compounds such as glucocorticoids (GCs). The ...
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Evaluating and developing sealants for the prevention of pulmonary air leakage: A systematic review of animal models Lab. Anim. (IF 2.4) Pub Date : 2023-04-10 Bob P. Hermans, Steven E.M. Poos, Daniël I.M. van Dort, Jort Evers, Wilson W.L. Li, Erik H.F.M. van der Heijden, Ad F.T.M. Verhagen, Harry van Goor, Richard P.G. ten Broek
Sealants may provide a solution for pulmonary air leakage (PAL), but their clinical application is debatable. For sealant comparison, standardized animal models are lacking. This systematic review ...
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Dental implants in large animal models with experimental systemic diseases: A systematic review Lab. Anim. (IF 2.4) Pub Date : 2023-04-06 Flávia Gomes Matos, Anna Clara Abreu Stremel, Leandro Cavalcante Lipinski, Joni Augusto Cirelli, Fábio André dos Santos
This systematic review aims to identify and discuss the most used methodologies in pre-clinical studies for the evaluation of the implementation of dental implants in systemically compromised pigs ...
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Let’s do it right: Eight steps to competence in laboratory animal science in the European Union Lab. Anim. (IF 2.4) Pub Date : 2023-03-24 Rafael Frías
Demonstrated competence in laboratory animal science (LAS) is a prerequisite in Directive 2010/63/EU to work with animals used in scientific procedures, as it is essential to increase animal welfar...
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Evaluation of the effect of tramadol, paracetamol and metamizole on the severity of experimental colitis Lab. Anim. (IF 2.4) Pub Date : 2023-03-24 Marianne Spalinger, Marlene Schwarzfischer, Anna Niechcial, Kirstin Atrott, Andrea Laimbacher, Paulin Jirkof, Michael Scharl
Application of dextran sodium sulfate (DSS) is often used to induce experimental colitis. Current state of the art is to refrain from the use of analgesics due to their possible interaction with th...
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Survey among FELASA members about rehoming of animals used for scientific and educational purposes Lab. Anim. (IF 2.4) Pub Date : 2023-03-24 Christel PH Moons, Andrea M Spiri, Jackie Boxall, Annet Louwerse, Lars F Mikkelsen, Mirjam Roth, Emilie Ecuer
Rehoming is an important fate, which should be considered for animals used for scientific and educational purposes, and which is highlighted in the European Directive 2010/63 EU. In 2018, the Feder...
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FELASA recommendations for the rehoming of animals used for scientific and educational purposes Lab. Anim. (IF 2.4) Pub Date : 2023-03-24 Emilie Ecuer, Jackie Boxall, Annet L Louwerse, Lars F Mikkelsen, Christel PH Moons, Mirjam Roth, Andrea M Spiri
Directive 2010/63/EU of the European Parliament and the Council of 22 September 2010 states that at the end of a procedure, the most appropriate decision on the future of an animal previously used ...
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Education in laboratory animal science and the 3Rs Lab. Anim. (IF 2.4) Pub Date : 2023-03-13 Nuno Henrique Franco, Angela Kerton, David I. Lewis
While laboratory animal research continues to be crucial for scientific and medical advancement, it still raises relevant ethical considerations. In order to foster public trust and support, all an...
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Establishment of cell lines from individual zebrafish embryos Lab. Anim. (IF 2.4) Pub Date : 2023-03-09 Nathalie Geyer, Sabrina Kaminsky, Shir Confino, Zohar Ben-Moshe Livne, Yoav Gothilf, Nicholas S Foulkes, Daniela Vallone
With the increasing use of fish as model species for research, cell cultures derived from caudal fin explants as well as pre-hatching stage embryos have provided powerful in vitro tools that can co...
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Management of dystocia due to secondary uterine inertia in rabbit (Oryctolagus cuniculus): A case report Lab. Anim. (IF 2.4) Pub Date : 2023-02-22 Vishal Yadav, Sandeep Dholpuria, Govind Narayan Purohit
In the present report a rabbit doe with dystocia due to uterine inertia was successfully managed medically by administration of oxytocin, calcium borogluconate and multivitamins, with delivery of t...
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Call for submissions: Special issue on facility design and management. Lab. Anim. (IF 2.4) Pub Date : 2023-02-22 Silvina L Diaz,Patrick Sharp,Xavier Warot
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Defining piscine endpoints: Towards score sheets for assessment of clinical signs in fish research Lab. Anim. (IF 2.4) Pub Date : 2023-02-21 L Andersen, A Rønneseth, MD Powell, A Brønstad
The seminar ‘Severity and humane endpoints in fish research’ organized by the University of Bergen, the Industrial and Aquatic Laboratory, together with Fondazione Guido Bernadini, took place on 4 ...
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When less is more: Experimental Bishop–Koop technique for reduction in the use of laboratory animals for intestinal pathophysiological studies Lab. Anim. (IF 2.4) Pub Date : 2023-02-07 Juan Cruz Abate, Natalia Lausada, Leandro Vecchio Dezillio, Jeremías Moreira, Ivana Ivanoff Marinoff, Maria Malena Ferreyra Compagnucci, Ane Miren Andrés Moreno, Carlota Largo, Martín Rumbo, Francisco Hernández Oliveros, David Romanin, Pablo Stringa
The use of animals to gain knowledge and understanding of diseases needs to be reduced and refined. In the field of intestinal research, because of the complexity of the gut immune system, living m...
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Case-based teaching of experimental design – contributions for meaningful learning Lab. Anim. (IF 2.4) Pub Date : 2023-02-04 Nuno H Franco, Derek J Fry
This article argues the need for education and training of researchers carrying out animal studies on the fundamentals of experimental design (ED), as a key means of improving the reliability and r...
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Scoring the Culture of Care as a key performance indicator in a global pharmaceutical company Lab. Anim. (IF 2.4) Pub Date : 2023-02-03 Océane Turkménian, Aurore Rocua, Thierry Decelle
Culture of Care has been an integral part of Sanofi’s policy on animal protection for more than 15 years. Culture of Care goes beyond compliance with regulations and standards, since it relates to ...
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Comparison of unilateral and bilateral embryo transfer in mice Lab. Anim. (IF 2.4) Pub Date : 2023-02-03 Kerstin E Auer, Thomas Kolbe, Claudia Laschalt, Thomas Rülicke
Surgical embryo transfer in mice is a key technique in assisted reproduction and applied for different purposes in biomedical research. Due to its frequent application in rodent facilities across t...
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Herbsttagung der IGTP vom 29.-30. September 2022 im Hamburg. Lab. Anim. (IF 2.4) Pub Date : 2023-02-01
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A successful return to in-person LASA Annual Conference 2022. Lab. Anim. (IF 2.4) Pub Date : 2023-02-01 Amy Warner,Beverley Law,Jordi L Tremoleda
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Automatic measurement of mouse visual acuity based on optomotor response: SKY optomotry Lab. Anim. (IF 2.4) Pub Date : 2023-01-28 So Yeon Ahn, Eun Hye Jung, Hyunmin Ahn, Jihei Sara Lee, Jeong Hyeon Bak, Eun-do Kim, Ja-Hyun Song, Hae-Sol Shin, Munkhdelger Jamiyansharav, Kyoung Yul Seo
In the field of visual science study using rodents, several assessment methods have been developed for measuring visual function. However, methods such as electroretinograms tests, visual evoked po...
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Psychological stress and strain in laboratory animal professionals – a systematic review Lab. Anim. (IF 2.4) Pub Date : 2023-01-23 Sonja Rumpel, Regina Kempen, Roswitha Merle, Christa Thoene-Reineke
Laboratory animal professionals (LAP) are faced with various situations and tasks influencing their mental well-being. A systematic review has been conducted to investigate whether there are specif...
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Watching me … watching you: Training and assessment in a virtual world Lab. Anim. (IF 2.4) Pub Date : 2023-01-16 Lucy Whitfield
Virtual education isn’t new. Teaching has been delivered remotely for many years, although it came to prominence with the enforced move to online learning during the COVID-19 pandemic. Technologies...
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The human skin organ culture model as an optimal complementary tool for murine pemphigus models Lab. Anim. (IF 2.4) Pub Date : 2023-01-16 Veronika Hartmann, William VJ Hariton, Siavash Rahimi, Christoph M Hammers, Ralf J Ludwig, Eliane J Müller, Jennifer E Hundt
Pemphigus is a severe autoimmune bullous disease of the skin and/or mucous membranes caused by autoantibodies that mainly target the adhesion proteins desmoglein (Dsg) 3 and/or Dsg1. Clinically, pe...
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Engaging on discussions about the use and the replacement of animals in research with young minds. Lab. Anim. (IF 2.4) Pub Date : 2023-01-16 Jordi L Tremoleda,Christopher Cederroth,Paulin Jirkof
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The role of environmental enrichment in the aetiopathogenesis of Staphylococcus aureus facial, periorbital and retroorbital abscesses in mice Lab. Anim. (IF 2.4) Pub Date : 2023-01-12 José M Sánchez-Morgado
In this observational retrospective study, an outbreak of Staphylococcus aureus abscesses was correlated with the presence of sharp edges in damaged plastic environmental enrichment within the cage...