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The Repertoire of Glycan Alterations and Glycoproteins in Human Cancers OMICS (IF 2.507) Pub Date : 2021-01-06 Medi Kori; Busra Aydin; Gizem Gulfidan; Hande Beklen; Nurdan Kelesoglu; Ayşegul Caliskan Iscan; Beste Turanli; Can Erzik; Betul Karademir; Kazim Yalcin Arga
Cancer as the leading cause of death worldwide has many issues that still need to be addressed. Since the alterations on the glycan compositions or/and structures (i.e., glycosylation, sialylation, and fucosylation) are common features of tumorigenesis, glycomics becomes an emerging field examining the structure and function of glycans. In the past, cancer studies heavily relied on genomics and transcriptomics
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Rethinking Clinical Trials and Personalized Medicine with Placebogenomics and Placebo Dose OMICS (IF 2.507) Pub Date : 2021-01-05 Vural Özdemir; Laszlo Endrenyi
Pharmacogenomics, nutrigenomics, vaccinomics, and the nascent field of plant omics are examples of variability science. They are embedded within an overarching framework of personalized medicine. Across these public health specialties, the significance and biology of the placebo response have been historically neglected. A placebo is any substance such as a sugar pill administered in the guise of medication
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Coronavirus Disease-2019 Treatment Strategies Targeting Interleukin-6 Signaling and Herbal Medicine. OMICS (IF 2.507) Pub Date : 2021-01-05 Kevin Dzobo,Harry Chiririwa,Collet Dandara,Witness Dzobo
Coronavirus disease-2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is evolving across the world and new treatments are urgently needed as with vaccines to prevent the illness and stem the contagion. The virus affects not only the lungs but also other tissues, thus lending support to the idea that COVID-19 is a systemic disease. The current vaccine
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In Silico Tools and Approaches for the Prediction of Functional and Structural Effects of Single-Nucleotide Polymorphisms on Proteins: An Expert Review OMICS (IF 2.507) Pub Date : 2021-01-05 Metin Yazar; Pemra Özbek
Single-nucleotide polymorphisms (SNPs) are single-base variants that contribute to human biological variation and pathogenesis of many human diseases. Among all SNP types, nonsynonymous single-nucleotide polymorphisms (nsSNPs) can alter many structural, biochemical, and functional features of a protein such as folding characteristics, charge distribution, stability, dynamics, and interactions with
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A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease OMICS (IF 2.507) Pub Date : 2021-01-05 Boštjan Petrič; Tanja Kunej; Aljoša Bavec
Paraoxonase 1 (PON1) enzyme has antioxidative properties and is present in mammalian blood and several other body fluids. In blood, PON1 is usually integrated into the high-density lipoprotein (HDL) cholesterol. PON1 is a highly versatile enzyme displaying diverse functions such as arylesterase, lactonase, and paraoxonase, among others. PON1 activities are usually investigated with artificial substrates
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What Do Students in Pharmacy and Medicine Think About Pharmacogenomics and Personalized Medicine Education? Awareness, Attitudes, and Perceptions in Malaysian Health Sciences OMICS (IF 2.507) Pub Date : 2021-01-05 Stavroula Siamoglou; Maria Koromina; Foong-Ming Moy; Christina Mitropoulou; George P. Patrinos; Konstantinos Vasileiou
This study reports on the attitudes and perceptions toward pharmacogenomics (PGx) and personalized medicine (PM) education among pharmacy and medical students in Malaysian health sciences. Importantly, the survey was developed through a codesign approach, with field pretesting/design with users before the actual survey, and based on collaboration between institutions in Greece and Malaysia. The study
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Bacterial Taxa Migrating from the Mediterranean Sea into the Red Sea Revealed a Higher Prevalence of Anti-Lessepsian Migrations OMICS (IF 2.507) Pub Date : 2021-01-05 Esraa Elsaeed; Nora Fahmy; Amro Hanora; Shymaa Enany
In 1869, the Suez Canal was opened, which brought the waters of the Mediterranean and the Red Sea into direct contact. Notably, the Suez Canal was constructed for navigation purposes without focusing on the ecological impacts. The Suez Canal paved the way for species migration from the Red Sea to the Mediterranean Sea through Lessepsian migration, named after Ferdinand de Lesseps, while the migration
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Turning Up the Volume for Precision Herbal Medicine in Africa in an Era of COVID-19 and Planetary Biodiversity Loss. OMICS (IF 2.507) Pub Date : 2020-12-04 Nicholas Ekow Thomford,Ewura Seidu Yahaya,Martins Ekor,Charles Awortwe
What would it take in terms of the structural reforms in science, technology, and culture to cultivate sustainable therapeutic and preventive medicine innovations against zoonotic infections such as coronavirus disease 2019 (COVID-19) in the 21st century? In May 2019, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services warned that “around one million animal and plant
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COVID-19 Pandemic in the Midst of Civil War: Planetary Health and Plant Omics Field Notes from Aden, Yemen OMICS (IF 2.507) Pub Date : 2020-12-04 Abdulsamad Taresh Abdullah; Jawdat Hassen; Areeg Abdulsamad Abdullah; Mehmet Ağırbaşlı
As the coronavirus disease 2019 (COVID-19) pandemic is impacting on the entire planet, field notes from resource-limited settings are increasingly relevant, both instrumentally and normatively, due to codependency of world populations in the struggle against the pandemic. Yemen is an apt and timely example to illustrate the social and political determinants of planetary health and the ways in which
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An Omics Study of Iron and Zinc Homeostasis in Finger Millet: Biofortified Foods for Micronutrient Deficiency in an Era of Climate Change? OMICS (IF 2.507) Pub Date : 2020-12-04 Ajay Kumar Chandra,Dinesh Pandey,Apoorv Tiwari,Divya Sharma,Aparna Agarwal,Salej Sood,Anil Kumar
The future of food and sustainability of the staple food crops are of utmost importance in the 21st century. Micronutrient deficiency, for example, in iron and zinc, is a common cause of human diseases. Mineral content of the staple food crops has therefore crosscutting importance for food engineering and planetary health. Finger millet, a staple food of agricultural importance worldwide, is rich in
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What Differentiates Probiotic from Pathogenic Bacteria? The Genetic Mobility of Enterococcus faecium Offers New Molecular Insights. OMICS (IF 2.507) Pub Date : 2020-12-04 Dayane da Silva Santos,Priscilla Régia de Andrade Calaça,Ana Lúcia Figueiredo Porto,Paulo Roberto Eleutério de Souza,Nara Suzy Aguiar de Freitas,Maria Taciana Cavalcanti Vieira Soares
Enterococcus faecium is a lactic acid bacterium with applications in food engineering and nutrigenomics, including as starter cultures in fermented foods. To differentiate the E. faecium probiotic from pathogenic bacteria, physiological analyses are often used but they do not guarantee that a bacterial strain is not pathogenic. We report here new findings and an approach based on comparison of the
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Plant-Pathogen Interactions: Broad Mite (Polyphagotarsonemus latus)-Induced Proteomic Changes in Chili Pepper Plant (Capsicum frutescens). OMICS (IF 2.507) Pub Date : 2020-12-04 Sachin S Patavardhan,Pratigya Subba,Altaf Najar,Kriti Awasthi,Leo D'Souza,Thottethodi Subrahmanya Keshava Prasad,Shashi Kiran Nivas
Plant–pathogen interactions are key biological events that shape ecological dynamics, food production, agriculture and economy. In this context, Capsicum frutescens is an economically and culturally significant chili pepper plant grown widely across the globe as an essential ingredient of hot sauces, chili concentrates, oleoresin flavors, and also in traditional medicines. An important pathogen that
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Plant Omics: Metabolomics and Network Pharmacology of Liquorice, Indian Ayurvedic Medicine Yashtimadhu OMICS (IF 2.507) Pub Date : 2020-12-04 Gayathree Karthikkeyan; Ravishankar Pervaje; Yashwanth Subbannayya; Arun H. Patil; Prashant Kumar Modi; Thottethodi Subrahmanya Keshava Prasad
Plant omics is an emerging field of systems science and offers the prospects of evidence-based evaluation of traditional herbal medicines in human diseases. To this end, the powdered root of Yashtimadhu (Glycyrrhiza glabra L.), commonly known as liquorice, is frequently used in Indian Ayurvedic medicine with an eye to neuroprotection but its target proteins, mechanisms of action, and metabolites remain
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Assembly and Annotation of the Nuclear and Organellar Genomes of a Dwarf Coconut (Chowghat Green Dwarf) Possessing Enhanced Disease Resistance OMICS (IF 2.507) Pub Date : 2020-12-04 Rajesh Krishna Muliyar; Pallem Chowdappa; Santosh Kumar Behera; Sandeep Kasaragod; Karyath Palliyath Gangaraj; Chinmaya Narayana Kotimoole; Bhagya Nekrakalaya; Varshasnata Mohanty; Rohith Bilgi Sampgod; Gaurab Banerjee; Anupam J. Das; Vittal Niral; Anitha Karun; Ajay Kumar Mahato; Kishor Gaikwad; Nagendra Kumar Singh; Thottethodi Subrahmanya Keshava Prasad
Coconut (Cocos nucifera L.), an important source of vegetable oil, nutraceuticals, functional foods, and housing materials, provides raw materials for a repertoire of industries engaged in the manufacture of cosmetics, soaps, detergents, paints, varnishes, and emulsifiers, among other products. The palm plays a vital role in maintaining and promoting the sustainability of farming systems of the fragile
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Thermal Proteome Profiling and Meltome Analysis of a Thermophilic Bacterial Strain, Geobacillus thermoleovorans ARTRW1: Toward Industrial Applications OMICS (IF 2.507) Pub Date : 2020-12-04 Merve Oztug; Evren Kilinc; Muslum Akgoz; Nevin Gul Karaguler
Thermophilic microorganisms that thrive in extreme environments are of great importance because they express heat-resistant enzymes with the potential to serve as biocatalysts in industrial applications. Thermal proteome profiling (TPP) is a multiplexed quantitative mass spectrometry method for analyses of structural information and melting behavior of thousands of proteins, simultaneously determining
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A Gapless, Unambiguous RNA Metagenome-Assembled Genome Sequence of a Unique SARS-CoV-2 Variant Encoding Spike S813I and ORF1a A859V Substitutions OMICS (IF 2.507) Pub Date : 2020-11-30 May S. Soliman; May AbdelFattah; Soad M.N. Aman; Lamyaa M. Ibrahim; Ramy K. Aziz
The novel severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is causing an unprecedented pandemic, threatening planetary health, society, and economy. Genomic surveillance continues to be a critical effort toward tracking the virus and containing its spread, and more genomes from diverse geographical areas and different time points are needed to provide an appropriate representation of the
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Cancer Stem Cell Markers in Relation to Patient Survival Outcomes: Lessons for Integrative Diagnostics and Next-Generation Anticancer Drug Development OMICS (IF 2.507) Pub Date : 2020-11-10 Kevin Dzobo; Chelene Ganz; Nicholas Ekow Thomford; Dimakatso Alice Senthebane
Solid tumors display a complex biology that requires a multipronged treatment strategy. Most anticancer interventions, including chemotherapy, are currently unable to prevent treatment resistance and relapse. In general, therapeutics target cancer cells and overlook the tumor microenvironment (TME) and the presence of cancer stem cells (CSCs) with self-renewal and tumorigenic abilities. CSCs have been
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Biotherapeutic Products, Cellular Factories, and Multiomics Integration in Metabolic Engineering OMICS (IF 2.507) Pub Date : 2020-11-04 Nguyen Hoang Anh; Jung Eun Min; Sun Jo Kim; Nguyen Phuoc Long
Since the introduction of the first monoclonal antibody, biopharmaceuticals and biotherapeutic products manufactured in cellular factories are on the rise in modern medicine and therapeutics. Dynamic and real-time innovation strategies for operational implementation of biotherapeutic production are rapidly emerging. The advances in related fields such as genome editing technology, systems biology,
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Molecular Basis of Pathogenesis of Coronaviruses: A Comparative Genomics Approach to Planetary Health to Prevent Zoonotic Outbreaks in the 21st Century. OMICS (IF 2.507) Pub Date : 2020-11-04 Purva Asrani,Gulam Mustafa Hasan,Sukhwinder Singh Sohal,Md Imtaiyaz Hassan
In the first quarter of the 21st century, we are already facing the third emergence of a coronavirus outbreak, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 (COVID-19) pandemic. Comparative genomics can inform a deeper understanding of the pathogenesis of COVID-19. Previous strains of coronavirus, SARS-CoV, and Middle-East respiratory
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“One Nature”: A New Vocabulary and Frame for Governance Innovation in Post-COVID-19 Planetary Health OMICS (IF 2.507) Pub Date : 2020-11-04 Vural Özdemir
Health futures are not preordained, nor are they entirely predictable by extrapolation from the past. This is particularly relevant in an era of unprecedented uncertainties converging from the COVID-19 pandemic, multiple zoonotic outbreaks for the past two decades, and the climate crisis currently unfolding. Moreover, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services
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Postmortomics: The Potential of Untargeted Metabolomics to Highlight Markers for Time Since Death OMICS (IF 2.507) Pub Date : 2020-11-04 Bogumila K. Pesko; Stefan Weidt; Mark McLaughlin; Daniel J. Wescott; Hazel Torrance; Karl Burgess; Richard Burchmore
The success of forensic investigations involving fatalities very often depends on the establishment of the correct timeline of events. Currently used methods for estimating the postmortem interval (PMI) are mostly dependent on the professional and tacit experience of the investigator, and often with poor reliability in the absence of robust biological markers. The aim of this study was to investigate
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Development of Rapid Pharmacogenomic Testing Assay in a Mobile Molecular Biology Laboratory (2MoBiL) OMICS (IF 2.507) Pub Date : 2020-11-04 Georgios Psarias; Evanthia Iliopoulou; Ioannis Liopetas; Anna Tsironi; Dimitrios Spanos; Athina Tsikrika; Konstantinos Kalafatis; Dimitra Tarousi; Georgios Varitis; Maria Koromina; Stavroula Siamoglou; George P. Patrinos
Pharmacogenomics is rapidly assuming an integral part in modern health care. Still, its broad applicability relies on the feasibility of performing pharmacogenomic testing in all clinical settings, including in remote areas or resource-limited settings with budget restrictions. In this study, we describe the development and feasibility of rapid and reliable pharmacogenomics assays using a portable
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Insights Into the Mechanism of Anticancer Drug Imatinib Revealed Through Multi-Omic Analyses in Yeast OMICS (IF 2.507) Pub Date : 2020-11-04 Hilal Taymaz-Nikerel; Serpil Eraslan; Betül Kırdar
Imatinib mesylate is a receptor tyrosine kinase inhibitor drug with broad applications in cancer therapeutics, for example, in chronic myeloid leukemia and gastrointestinal stromal tumors. In this study, new multi-omics findings in yeast on the mechanism of imatinib are reported, using the model organism Saccharomyces cerevisiae. Whole-genome analysis of the transcriptional response of yeast cells
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Global Open Health Data Cooperatives Cloud in an Era of COVID-19 and Planetary Health OMICS (IF 2.507) Pub Date : 2020-10-13 Ankit Singh Tanwar; Nikolaos Evangelatos; Julien Venne; Lesley Ann Ogilvie; Kapaettu Satyamoorthy; Angela Brand
Big data in both the public domain and the health care industry are growing rapidly, for example, with broad availability of next-generation sequencing and large-scale phenomics datasets on patient-reported outcomes. In parallel, we are witnessing new research approaches that demand sharing of data for the benefit of planetary society. Health data cooperatives (HDCs) is one such approach, where health
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The Sickle Cell Disease Ontology: Enabling Collaborative Research and Co-Designing of New Planetary Health Applications OMICS (IF 2.507) Pub Date : 2020-10-05 Victoria Nembaware; Gaston K. Mazandu; Jade Hotchkiss; Jean-Michel Safari Serufuri; Jill Kent; Andre Pascal Kengne; Kofi Anie; Nchangwi Syntia Munung; Daima Bukini; Valentina Josiane Ngo Bitoungui; Deogratias Munube; Uzima Chirwa; Catherine Chunda-Liyoka; Agnes Jonathan; Miriam V. Flor-Park; Kevin Kum Esoh; Mario Jonas; Khuthala Mnika; Chandré Oosterwyk; Upendo Masamu; Jack Morrice; Annette Uwineza;
Sickle cell disease (SCD) is one of the most common blood disorders impacting planetary health. Over 300,000 newborns are diagnosed with SCD each year globally, with an increasing trend. The sickle cell disease ontology (SCDO) is the most comprehensive multidisciplinary SCD knowledge portal. The SCDO was collaboratively developed by the SCDO working group, which includes experts in SCD and data standards
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In silico Potential of Approved Antimalarial Drugs for Repurposing Against COVID-19. OMICS (IF 2.507) Pub Date : 2020-10-05 Cheryl Sachdeva,Anju Wadhwa,Anita Kumari,Firasat Hussain,Preeti Jha,Naveen K Kaushik
Although the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is wreaking havoc and resulting in mortality and morbidity across the planet, novel treatments are urgently needed. Drug repurposing offers an innovative approach in this context. We report here new findings on the in silico potential of several antimalarial drugs for
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Digging Deeper into Breast Cancer Epigenetics: Insights from Chemical Inhibition of Histone Acetyltransferase TIP60 In Vitro. OMICS (IF 2.507) Pub Date : 2020-10-05 Mouhamed Idrissou,Andre Lebert,Tiphanie Boisnier,Anna Sanchez,Fatma Zohra Houfaf Khoufaf,Frédérique Penault-Llorca,Yves-Jean Bignon,Dominique Bernard-Gallon
Breast cancer is often sporadic due to several factors. Among them, the deregulation of epigenetic proteins may be involved. TIP60 or KAT5 is an acetyltransferase that regulates gene transcription through the chromatin structure. This pleiotropic protein acts in several cellular pathways by acetylating proteins. RNA and protein expressions of TIP60 were shown to decrease in some breast cancer subtypes
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Microbiome and Longevity: High Abundance of Longevity-Linked Muribaculaceae in the Gut of the Long-Living Rodent Spalax leucodon. OMICS (IF 2.507) Pub Date : 2020-10-05 Mustafa Sibai,Ebru Altuntaş,Berna Yıldırım,Gürkan Öztürk,Süleyman Yıldırım,Turan Demircan
With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the blind mole-rat (Spalax leucodon), a subterranean mammalian, has emerged as an exceptional model organism due to its astonishing features such as remarkable longevity, hypoxia and hypercapnia
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Changes in Vaginal Microbiome in Pregnant and Nonpregnant Women with Bacterial Vaginosis: Toward Microbiome Diagnostics? OMICS (IF 2.507) Pub Date : 2020-10-05 Ibrahim Mohamed,Samira Zakeer,Marwa Azab,Amro Hanora
Bacterial vaginosis (BV) is highly common, adversely affecting the health of millions of women. New therapeutic targets and diagnostics are urgently needed for BV. Microbiome research offers new prospects in this context. We report here original findings on changes in the vaginal microbiome in pregnant and nonpregnant women with BV. Reproductive age women were recruited for this study after a clinical
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Digital Health in Physicians' and Pharmacists' Office: A Comparative Study of e-Prescription Systems' Architecture and Digital Security in Eight Countries. OMICS (IF 2.507) Pub Date : 2020-09-15 Bader Aldughayfiq,Srinivas Sampalli
e-Prescription systems are key components and drivers of digital health. They can enhance the safety of the patients, and are gaining popularity in health care systems around the world. Yet, there is little knowledge on comparative international analysis of e-Prescription systems' architecture and digital security. We report, in this study, original findings from a comparative analysis of the e-Prescription
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Post-Coronavirus Disease 2019 Health Care and University: From Efficiency to Resilience. OMICS (IF 2.507) Pub Date : 2020-09-02 İsmail Akar
After the initial emergency responses deployed to control the coronavirus disease 2019 (COVID-19) pandemic in the first half of 2020, we should now start thinking about long-term strategies and concepts for pandemic and disaster governance such as resilience. In this context, COVID-19 health care and education are especially important because they are essential public goods that determine what kind
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A Systems View of the Genome Guardians: Mapping the Signaling Circuitry Underlying Oligonucleotide/Oligosaccharide-Binding Fold Proteins. OMICS (IF 2.507) Pub Date : 2020-09-02 Mohd Amir,Aftab Alam,Romana Ishrat,Mohamed F Alajmi,Afzal Hussain,Md Tabish Rehman,Asimul Islam,Faizan Ahmad,Md Imtaiyaz Hassan,Ravins Dohare
The oligonucleotide/oligosaccharide-binding (OB)-fold domain proteins are considered as genome guardians, whose functions are extending beyond genomic stability. The broad functional diversity of the OB-fold proteins is attributed to their protein-DNA, protein-RNA, and protein-protein interactions (PPI). To understand the connectivity of the human OB-fold proteins, we report here a systems-level approach
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Dentistry and OMICS: Transcriptome Dynamics of an Oral Ecosystem as Measured by Changes in Oral Polymorphonuclear Neutrophils in Experimental Gingivitis. OMICS (IF 2.507) Pub Date : 2020-09-02 Patrick Rijkschroeff,Ton Schoenmaker,Martien Caspers,Lars Verschuren,Bart J F Keijser,Elena A Nicu,Bruno G Loos
Oral health and dentistry are essential components of systems medicine, which has received lesser attention in comparison to other medical fields, such as cancer biology. In this context, oral polymorphonuclear neutrophils (oPMNs) play an important role in the maintenance of oral health. To the best of our knowledge, this is the first study to report original observations on the transcriptional responses
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Comparative Metagenomic Screening of Aromatic Hydrocarbon Degradation and Secondary Metabolite-Producing Genes in the Red Sea, the Suez Canal, and the Mediterranean Sea. OMICS (IF 2.507) Pub Date : 2020-09-02 Esraa Elsaeed,Shymaa Enany,Amro Hanora,Nora Fahmy
Marine and ecosystem pollution due to oil spills can be addressed by identifying the aromatic hydrocarbon (HC)-degrading microorganisms and their responsible genes for biodegradation. Moreover, screening for genes coding for secondary metabolites is invaluable for drug discovery. We report here, the first metagenomic study investigating the shotgun metagenome of the Suez Canal water sampled at Ismailia
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Glycomics: Immunoglobulin G N-Glycosylation Associated with Mammary Gland Hyperplasia in Women. OMICS (IF 2.507) Pub Date : 2020-09-02 Zixiu Meng,Cancan Li,Guoyong Ding,Weijie Cao,Xizhu Xu,Yuanyuan Heng,Yang Deng,Yuejin Li,Xiaoyu Zhang,Dong Li,Wei Wang,Youxin Wang,Weijia Xing,Haifeng Hou
Mammary gland hyperplasia (MGH) is very common, especially among young and middle-aged women. New diagnostics and biomarkers for MGH are needed for rational clinical management and precision medicine. We report, in this study, new findings using a glycomics approach, with a focus on immunoglobulin G (IgG) N-glycosylation. A cross-sectional study was conducted in a community-based population sample
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COVID-19 Pandemic: Hopes from Proteomics and Multiomics Research. OMICS (IF 2.507) Pub Date : 2020-08-03 Sandipan Ray,Sanjeeva Srivastava
The successful sequencing of the novel coronavirus SARS-CoV-2 nucleic acid paved the way for exploration of omics systems science and integrative biology research approaches for combating this unprecedented planetary health challenge. Omics-scale studies on this viral infection are emerging rapidly and offer a tremendous potential to unravel the puzzles of the SARS-CoV-2 pathobiology, and ways forward
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COVID-19 Digital Health Innovation Policy: A Portal to Alternative Futures in the Making. OMICS (IF 2.507) Pub Date : 2020-08-03 Mustafa Bayram,Simon Springer,Colin K Garvey,Vural Özdemir
“The pandemic is a portal.” In the words of the novelist scholar Arundhati Roy, the COVID-19 pandemic is not merely an epic calamity. It has opened up a new space, a portal, to rethink everything, for example, in how we live, work, produce scientific knowledge, provide health care, and relate to others, be they humans or nonhuman animals in planetary ecosystems. Meanwhile, as the intensity of the pandemic
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Singapore COVID-19 Pandemic Response as a Successful Model Framework for Low-Resource Health Care Settings in Africa? OMICS (IF 2.507) Pub Date : 2020-08-03 Oppah Kuguyo,Andre Pascal Kengne,Collet Dandara
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to spread and evolve across the planet. The crosscutting impacts of the virus, individual country responses to the virus, and the state of preparedness of local public health systems greatly vary across the world. The ostensibly late arrival of the virus in Africa
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COVID-19 Science Policy, Experts, and Publics: Why Epistemic Democracy Matters in Ecological Crises. OMICS (IF 2.507) Pub Date : 2020-08-03 Marco Boschele
In times of planetary health crises such as the COVID-19 pandemic, a critically informed science and technology policy is crucial. In this overarching context, governments are faced with making rapid and high-stake decisions dictated by emergency that in a state of normalcy they would not, or could not pursue. Governments tend to gather, therefore, an incredible amount of unchecked power in times of
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Intracranial Aneurysm Biomarker Candidates Identified by a Proteome-Wide Study. OMICS (IF 2.507) Pub Date : 2020-08-03 Tanavi Sharma,Keshava K Datta,Munish Kumar,Gourav Dey,Aafaque Ahmad Khan,Kiran Kumar Mangalaparthi,Poonam Saharan,Shobia Chinnapparaj,Ashish Aggarwal,Navneet Singla,Sujata Ghosh,Amit Rawat,Sivashanmugam Dhandapani,Pravin Salunke,Rajesh Chhabra,Dalbir Singh,Aastha Takkar,Sunil K Gupta,Thottethodi Subrahmanya Keshava Prasad,Harsha Gowda,Kanchan K Mukherjee,Akhilesh Pandey,Hemant Bhagat
The scientific basis of intracranial aneurysm (IA) formation, its rupture and further development of cerebral vasospasm is incompletely understood. Aberrant protein expression may drive structural alterations of vasculature found in IA. Deciphering the molecular mechanisms underlying these events will lead to identification of early detection biomarkers and in turn, improved treatment outcomes. To
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Toward High-Throughput Fungal Electroculturomics and New Omics Methodologies in 21st-Century Microbiology and Ecology. OMICS (IF 2.507) Pub Date : 2020-08-03 Andreas Stathoulias,Aphroditi Milioni,Stavroula Kritikou,Aikaterini Karmakolia,Stavroula Goudoudaki,Stavroula Siamoglou,Constantinos Chassomeris,Stamatis Vassilakis,Kariofyllis Karamperis,Aristea Velegraki,Cleo Anastassopoulou,Yiannis Manoussopoulos,George P Patrinos,Manousos E Kambouris
Modern microbiology and drug development are in a watershed moment with the advent of electroceuticals. In addition to genomics, electrical impulses in an organism are believed to contribute to tissue and cellular plasticity. Hence, electroceuticals or bioelectronics offers the promise to identify innovative approaches to treat human diseases. However, applications toward electromicrobiology are still
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COVID-19 Pandemic and Africa: From the Situation in Zimbabwe to a Case for Precision Herbal Medicine. OMICS (IF 2.507) Pub Date : 2020-07-10 Collet Dandara,Kevin Dzobo,Shadreck Chirikure
This opinion commentary on the coronavirus disease 2019 (COVID-19) pandemic brings together observations from Zimbabwe specifically, and Africa broadly, drawing from the fields of pharmacogenomics, precision herbal medicine, and responsible innovation so as to respond to the pandemic in ways that are efficient, critically informed, principled, and responsive to needs in rural and urban communities
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Molecular Targets from Traditional Medicines for Neuroprotection in Human Neurodegenerative Diseases. OMICS (IF 2.507) Pub Date : 2020-07-06 Sayali Chandrashekhar Deolankar,Prashant Kumar Modi,Yashwanth Subbannayya,Ravishankar Pervaje,Thottethodi Subrahmanya Keshava Prasad
Neurodegeneration is one of the greatest threats to global public health. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease are among the major causes of chronic neurological conditions in the elderly populations. Hence, neuroprotection is at the epicenter of the current 21st-century research agenda in biomedicine. Yet
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Serum Metabolome Changes in Relation to Prothrombotic State Induced by Combined Oral Contraceptives with Drospirenone and Ethinylestradiol. OMICS (IF 2.507) Pub Date : 2020-07-06 Albe Carina Swanepoel,Janette Bester,Odette Emmerson,Prashilla Soma,Derylize Beukes,Mari van Reenen,Du Toit Loots,Ilse du Preez
The association between hypercoagulability and use of drospirenone (DRSP) and ethinylestradiol (EE) containing combined oral contraceptives (COCs) is an important clinical concern. We have previously reported that the two formulations of DRSP combined with EE (namely, DRSP/20EE and DRSP/30EE) bring about a prothrombotic state in hemostatic traits of female users. We report here the serum metabolomic
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A Predictive Model Using N-Glycan Biosignatures for Clinical Diagnosis of Early Hepatocellular Carcinoma Related to Hepatitis B Virus. OMICS (IF 2.507) Pub Date : 2020-07-06 Min Cong,Xiaojuan Ou,Jian Huang,Jiang Long,Tong Li,Xueen Liu,Yanhong Wang,Xiaoning Wu,Jialing Zhou,Yameng Sun,Qinghua Shang,Guofeng Chen,Hui Ma,Wen Xie,Hongxin Piao,Yongping Yang,Zhiliang Gao,Xiaoyuan Xu,Zongnan Tan,Chitty Chen,Na Zeng,Shanshan Wu,Yuanyuan Kong,Tianhui Liu,Ping Wang,Hong You,Jidong Jia,Hui Zhuang
Early diagnosis of hepatic cancer is a major public health challenge. While changes in serum N-glycans have been observed as patients progress from liver fibrosis/cirrhosis to hepatocellular carcinoma (HCC), the predictive performance of N-glycans is yet to be determined for HCC early diagnosis as well as differential diagnosis from liver fibrosis/cirrhosis. In a total sample of 247 patients with hepatitis
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Nuclear Magnetic Resonance-Based Metabolomic Comparison of Breast Milk and Organic and Traditional Formula Milk Brands for Infants and Toddlers. OMICS (IF 2.507) Pub Date : 2020-07-06 Gaia Meoni,Leonardo Tenori,Claudio Luchinat
In recent years, new formula milk (FM) products based on milk from farms that strictly adhere to the “organic farming” practices became available. However, little is known about the differences in nutritional profile of these organic formulae with respect to traditional ones. We comprehensively evaluated the metabolite profiles of FM with nuclear magnetic resonance (NMR)-based metabolomic analysis
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The Role of Integrin α4β7 Signaling in Human Immunodeficiency Virus-1 Pathogenesis and Viral Entry in Primary CD4+ T Cells As Revealed by Comparative Phosphoproteomic Signatures. OMICS (IF 2.507) Pub Date : 2020-07-06 Nandini Kasarpalkar,Barnali Deb,Prashant Kumar,Vikrant M Bhor
Integrin α4β7, a CD4 independent receptor of human immunodeficiency virus-1 (HIV-1) gp120, defines a subset of CD4+T cells preferentially targeted by HIV. It is also considered as a promising therapeutic target for HIV-1 infection. Despite its role in HIV acquisition and disease progression, HIV-1-mediated integrin α4β7 signaling has not been elucidated so far. In view of this, we determined phosphoproteomic
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Architecture of Cancer-Associated Fibroblasts in Tumor Microenvironment: Mapping Their Origins, Heterogeneity, and Role in Cancer Therapy Resistance. OMICS (IF 2.507) Pub Date : 2020-06-03 Kevin Dzobo,Collet Dandara
The tumor stroma, a key component of the tumor microenvironment (TME), is a key determinant of response and resistance to cancer treatment. The stromal cells, extracellular matrix (ECM), and blood vessels influence cancer cell response to therapy and play key roles in tumor relapse and therapeutic outcomes. Of the stromal cells present in the TME, much attention has been given to cancer-associated
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Broadening Drug Design and Targets to Tumor Microenvironment? Cancer-Associated Fibroblast Marker Expression in Cancers and Relevance for Survival Outcomes. OMICS (IF 2.507) Pub Date : 2020-06-03 Kevin Dzobo,Collet Dandara
Solid tumors have complex biology and structure comprising cancer cells, stromal cells, and the extracellular matrix. While most therapeutics target the cancer cells, recent data suggest that cancer cell behavior and response to treatment are markedly influenced by the tumor microenvironment (TME). In particular, the cancer-associated fibroblasts (CAFs) are the most abundant stromal cells, and play
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Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (Ambystoma mexicanum) Model in Regenerative Medicine. OMICS (IF 2.507) Pub Date : 2020-06-03 Turan Demircan,Harbiye Hacıbektaşoğlu,Mustafa Sibai,Ece Cana Fesçioğlu,Ebru Altuntaş,Gürkan Öztürk,Barış Ethem Süzek
Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential preclinical model organisms in neurology and regenerative medicine research. Earlier studies have suggested that the limb regeneration ability of this salamander notably decreases with
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Digging Deeper for the Eye Proteome in Vitreous Substructures: A High-Resolution Proteome Map of the Normal Human Vitreous Base. OMICS (IF 2.507) Pub Date : 2020-06-03 Varshasnata Mohanty,Sneha M Pinto,Yashwanth Subbannayya,Mohd Altaf Najar,Kalpana Babu Murthy,Thottethodi Subrahmanya Keshava Prasad,Krishna R Murthy
Mapping the normal eye proteome in healthy persons is essential to unravel the molecular basis of diseases impacting visual health. The vitreous occupies a large portion of the human eye between the lens and the retina and plays a significant role in vitreoretinal diseases as well as maintaining clarity in the visual field, providing nutrition to the lens, and protecting the eye from mechanical shocks
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Shedding Light on the Transcriptomic Dark Matter in Biological Psychiatry: Role of Long Noncoding RNAs in D-cycloserine-Induced Fear Extinction in Posttraumatic Stress Disorder. OMICS (IF 2.507) Pub Date : 2020-06-03 Stefanie Malan-Müller,Vladimir B C de Souza,Willie M U Daniels,Soraya Seedat,Mark D Robinson,Sîan M J Hemmings
Biological psychiatry scholarship on posttraumatic stress disorder (PTSD) is making strides with new omics technologies. In this context, there is growing recognition that noncoding RNAs are vital for the regulation of gene and protein expression. Long noncoding RNAs (lncRNAs) can modulate splicing, influence RNA editing, messenger RNA (mRNA) stability, translation activation, and microRNA–mRNA interactions
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Do Not Forget Afghanistan in Times of COVID-19: Telemedicine and the Internet of Things to Strengthen Planetary Health Systems. OMICS (IF 2.507) Pub Date : 2020-06-03 Abdulmunir Azizy,Mujtaba Fayaz,Mehmet Agirbasli
Health care does not always take place in a setting of peace, prosperity, and social order, a point that is often overlooked in quotidian medical practice. This has become most evident with the current COVID-19 pandemic by the new coronavirus that is wreaking havoc across the planet. Health care providers are facing unprecedented challenges to intervene on numerous nonlinear uncertainties in science
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Rethinking Omics Education in Brazil and South America: From Genomics to Multiomics and Critical Policy Studies. OMICS (IF 2.507) Pub Date : 2020-05-15 Alberto M R Dávila
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Digital Transformation and Governance Innovation for Public Biobanks and Free/Libre Open Source Software Using a Blockchain Technology. OMICS (IF 2.507) Pub Date : 2020-05-07 Nikolaos Evangelatos,Sudhakara P Upadya,Julien Venne,Kapaettu Satyamoorthy,Helmut Brand,C S Ramashesha,Angela Brand
Digitalization and digital health are transforming research practices, while economic growth is increasingly driven by the information commons. In the case of biological sciences, information commons, such as public biobanks and free/libre open source software (FLOSS), are of paramount importance for both research and the bioeconomy. In a time of digitalization, however, information commons are vulnerable
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New Machine Learning Applications to Accelerate Personalized Medicine in Breast Cancer: Rise of the Support Vector Machines. OMICS (IF 2.507) Pub Date : 2020-05-07 Mustafa Erhan Ozer,Pemra Ozbek Sarica,Kazim Yalcin Arga
Artificial intelligence, machine learning, health care robots, and algorithms for clinical decision-making are currently being sought after in diverse fields of clinical medicine and bioengineering. The field of personalized medicine stands to benefit from new technologies so as to harness the omics big data, for example, to individualize and accelerate cancer diagnostics and therapeutics in particular
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Blockchain for Digital Health: Prospects and Challenges. OMICS (IF 2.507) Pub Date : 2020-05-07 Nikolaos Evangelatos,Vural Özdemir,Angela Brand
An open distributed ledger system, blockchain records digital transactions and offers the potential to disruptively transform the way we conduct biomedical research, provide health care, and perform economic transactions. This expert review provides the overarching background, key definitions, prospects and socio-technical challenges at the intersection of blockchain and digital health. In addition
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Implementing Artificial Intelligence and Digital Health in Resource-Limited Settings? Top 10 Lessons We Learned in Congenital Heart Defects and Cardiology. OMICS (IF 2.507) Pub Date : 2020-05-07 Nicholas Ekow Thomford,Christian Domilongo Bope,Francis Edem Agamah,Kevin Dzobo,Richmond Owusu Ateko,Emile Chimusa,Gaston Kuzamunu Mazandu,Simon Badibanga Ntumba,Collet Dandara,Ambroise Wonkam
Artificial intelligence (AI) is one of the key drivers of digital health. Digital health and AI applications in medicine and biology are emerging worldwide, not only in resource-rich but also resource-limited regions. AI predates to the mid-20th century, but the current wave of AI builds in part on machine learning (ML), big data, and algorithms that can learn from massive amounts of online user data
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Toward Algorithms for Automation of Postgenomic Data Analyses: Bacillus subtilis Promoter Prediction with Artificial Neural Network. OMICS (IF 2.507) Pub Date : 2020-05-07 Rafael Vieira Coelho,Gabriel Dall'Alba,Scheila de Avila E Silva,Sergio Echeverrigaray,Ana Paula Longaray Delamare<
In the present postgenomic era, the capacity to generate big data has far exceeded the capacity to analyze, contextualize, and make sense of the data in clinical, biological, and ecological applications. There is a great unmet need for automation and algorithms to aid in analyses of big data, in biology in particular. In this context, it is noteworthy that computational methods used to analyze the