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Silk-based microcarriers: current developments and future perspectives IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Anabela Veiga; Filipa Castro; Fernando Rocha; Ana Oliveira
Cell-seeded microcarriers (MCs) are currently one of the most promising topics in biotechnology. These systems are supportive structures for cell growth and expansion that allow efficient nutrient and gas transfer between the media and the attached cells. Silk proteins have been increasingly used for this purpose in the past few years due to their biocompatibility, biodegradability and non-toxicity
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Isolation, process optimisation and characterisation of the protein from the de-oiled cake flour of Madhuca latifolia IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Achyuta Kumar Biswal; Pradeep Kumar Panda; Jen-Ming Yang; Pramila Kumari Misra
This work reports the isolation of the protein from the flour of an underutilised agro waste, a de-oiled cake of Madhuca latifolia using the bis (2-ethylehexyl) sodium sulfosuccinate salt reverse micelle and the characterisation of the protein through various techniques. The experimental conditions for the extraction were optimised using Box–Behnken design. The highest yield of the protein was achieved
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Protein adsorption on spark plasma sintered 2d-, 3d- and lamellar type mesoporous silicate compacts IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Yoshiyuki Yokogawa; Keita Sasada; Koji Hirabayashi; Suguru Inamura; Takeshi Suyama
The preparation of lamellar type mesoporous silica (MPS) compact through the spark plasma sintering (SPS) and the adsorption/desorption of protein onto MPS compact are reported to be compared with those onto 2d-hexagonal and 3d-cubic type MPS compacts. A lamellar-type MPS powder (MPS-la) was prepared using triblock copolymer, PEO 5 PPO 68 PEO 5 , and was compacted in a carbon die and heated at 500°C
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Impartation of apatite-forming ability to chitosan nanofibres by using apatite nuclei IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Yu Adachi; Takeshi Yabutsuka; Shigeomi Takai
Chitosan nanofibre–apatite nuclei composites obtained by mixing apatite nuclei which possess high apatite-forming ability with chitosan nanofibre have been expected to be novel bone restorative materials with suitable properties such as light weight, low coefficient of thermal expansion, high mechanical strength, biocompatibility and bioactivity. In this study, the authors prepared three types of apatite
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Impartation of hydroxyapatite formation ability to ultra-high molecular weight polyethylene by deposition of apatite nuclei IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Takeshi Yabutsuka; Shigeomi Takai
The authors aimed to impart hydroxyapatite formation ability to ultra-high molecular weight polyethylene (UHMWPE) by deposition of apatite nuclei (ApN) by the following two methods. The first method was electrophoretic deposition (EPD). A porous UHMWPE was placed between electrodes in the ApN-dispersed ethanol and constant voltage was applied. By this treatment, the ApN were migrated from anode-side
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Zinc oxide nanoparticles augment CD4, CD8, and GLUT-4 expression and restrict inflammation response in streptozotocin-induced diabetic rats IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Norhan Elassy; Shady El-Dafrawy; Amira O. Abd El-Azim; Om Ali Y. El-Khawaga; Amr Negm
This study evaluated the biochemical, molecular, and histopathological mechanisms involved in the hypoglycaemic effect of zinc oxide nanoparticles (ZnONPs) in experimental diabetic rats. ZnONPs were prepared by the sol–gel method and characterised by scanning and transmission electron microscopy (SEM and TEM). To explore the possible hypoglycaemic and antioxidant effect of ZnONPs, rats were grouped
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Improvement of hydroxyapatite formation ability of titanium-based alloys by combination of acid etching and apatite nuclei precipitation IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Takeshi Yabutsuka; Yasutaka Kidokoro; Shigeomi Takai
The authors aimed to improve hydroxyapatite formation ability of Ti6Al4V, Ti-15Mo-5Zr-3Al alloy, Ti-12Ta-9Nb-6Zr-3V-O alloy (Gummetal®) and commercially pure Ti (cpTi) mesh by a combination of acid etching and apatite nuclei precipitation. Surfaces of specimens were etched with H 2 SO 4 for pores formation on the specimens. Thus-etched specimens were soaked in an alkalinised simulated body fluid (SBF)
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CdO nanoparticles, c-MWCNT nanoparticles and CdO nanoparticles/c-MWCNT nanocomposite fibres: in vitro assessment of anti-proliferative and apoptotic studies in HeLa cancer cell line IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Jayaraman Saranya; Balakrishnapillai Suseela Sreeja; Gurunathan Padmalaya; Sankararajan Radha; Ponnusamy Senthil Kumar
A simple ultrasonic assisted chemical technique was used to synthesise cadmium oxide (CdO) nanoparticles (NPs) and CdO NPs/c-Multiwalled carbon nanotube (c-MWCNT) nanocomposite fibres.To confirm the physio-chemico properties and to analyse surface morphology of the obtained nanomaterials X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and field emission scanning electron microscopy
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Development of bioactive zirconium–tin alloy by combination of micropores formation and apatite nuclei deposition IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Norihiro Hashimoto; Takeshi Yabutsuka; Shigeomi Takai
In previous studies, Zr gained apatite-forming ability by various methods; however, it took more than 7 days in simulated body fluid (SBF) to gain apatite-forming ability. In this study, the authors developed the method to achieve apatite-forming ability in Zr alloy within 1 day in SBF by a combination with apatite nuclei that promote apatite formation in SBF. First, Zr–Sn alloy was soaked in concentrated
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Green synthesis of AgCl/Ag3PO4 nanoparticle using cyanobacteria and assessment of its antibacterial, colorimetric detection of heavy metals and antioxidant properties IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Parisa Aletayeb; Parinaz Ghadam; Parisa Mohammadi
In this study, the extract of two strains of cyanobacteria was used for the synthesis of silver nanoparticles (NPs). UV–vis spectroscopy, X-ray diffraction, dynamic light scattering and field emission scanning electron microscopy (FESEM) analyses were carried out to characterise the NPs. The antioxidant activity and heavy metal detection properties were investigated; moreover, their minimum inhibitory
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Solvothermal-assisted green synthesis of hybrid Chi-Fe3O4 nanocomposites: a potential antibacterial and antibiofilm material IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Palanisamy Senthilkumar; Sudhagar Babu; Venkatachalam Jaishree; Kingsly Joshua Stephen; Govindaraj Yaswant; Devanesan Sanjeevi Ranjith Santhosh Kumar; Nithya S. Nair
In this present study, a hybrid Chi-Fe 3 O 4 was prepared, characterised and evaluated for its antibacterial and antibiofilm potential against Staphylococcus aureus and Staphylococcus marcescens bacterial pathogens. Intense peak around 260 nm in the ultraviolet–visible spectrum specify the formation of magnetite nanoparticles. Spherical-shaped particles with less agglomeration and particle size distribution
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Assessment of acaricidal activity of nanoscale ZnO encapsulated piperine formulation against Rhipicephalus microplus IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Snigdha Kancharana; Rayulu Vukka Chengalva; Srinivasa Rao Kothapalli; Muralidhar Yegireddy; Sreedevi Bollini; Prasad Tollamadugu Naga Venkata Krishna Vara
This study aims to synthesise and evaluate the acaricidal activity of nanoscale zinc oxide piperine formulation (NZPF) against Rhipicephalus microplus ticks. NZPF was prepared by using zinc oxide nanoparticles (ZnONPs) and piperine by employing encapsulation technique; characterised by UV spectroscopy, Fourier transformed infrared analysis, X-ray diffraction, dynamic light scattering, zetapotential
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Amino-functionalised mesoporous silica microspheres for immobilisation of Candida antarctica lipase B – application towards greener production of 2,5-furandicarboxylic acid IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Kongkona Saikia; Ponnusamy Senthil Kumar; Abiram Karanam Rathankumar; Sundar SaiLavanyaa; Lakshmi Srinivasan; Sivanesan Subramanian; Hubert Cabana; Mathilde Gosselin; Vaidyanathan Vinoth Kumar
In the present study, amino-functionalised mesoporous silica microspheres were utilised as support for the covalent immobilisation of Candida antarctica lipase B (CaLB) for the subsequent production of 2,5-furandicarboxylic acid (FDCA) from 2,5-diformylfuran (DFF). Under the optimised operating conditions of pH 6.5, particle/enzyme ratio of 1.25:1.0 and glutaraldehyde concentration of 4 mM, a maximum
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Lobelia trigona Roxb-based nanomedicine with enhanced biological applications: in vitro and in vivo approach IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-27 Rex Jeya Rajkumar Samdavid Thanapaul; Sreeraj K Manikandan; Tamil Selvan Govindaraj; Paulraj Mosae Selvakumar; Israel V.M.V. Enoch; Meenakshi Subbaraman Adyanpuram Muthukumar Nadar
This is the first study to report the green synthesis of Lobelia trigona Roxb- mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet–visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X-ray. LTAgNps were evaluated for their anti-bacterial and
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Surface-functionalised hybrid nanoparticles for targeted treatment of cancer IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Hasnat Tariq; Syed Ali Imran Bokhari
Cancer is a leading cause of death worldwide. Despite the great advancement in understanding the pharmacology and biology of cancer, it still signifies one of the most serious human-health related problems. The current treatments for cancer may include surgery, radiotherapy, and chemotherapy, but these procedures have several limitations. Current studies have shown that nanoparticles (NPs) can be used
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Biologically-synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Mahdi Bayrami; Abolfazl Bayrami; Aziz Habibi-Yangjeh; Mohammad Saleh Shafeeyan; Solmaz Feizpoor; Farid Mohammadi Arvanagh; Mohammad Reza Nourani; Ramezan Ali Taheri
Wound healing has long been recognised as a major clinical challenge for which stablishing more effective wound therapies is necessary. The generation of metallic nanocomposites using biological compounds is emerging as a new promising strategy for this purpose. In this study, four metallic nanoparticles (NPs) with propolis extract (Ext) and one without propolis including ZnO/Ext, ZnO/Ag/Ext, ZnO/CuO/Ext
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High yield gold nanoparticle-based DNA isolation method for human papillomaviruses genotypes from cervical cancer tissue samples IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Noorossadat Seyyedi; Fatemeh Farjadian; Ali Farhadi; Gholamreza Rafiei Dehbidi; Reza Ranjbaran; Farahnaz Zare; Mohammad Ali Okhovat; Negin Nikouyan; Abbas Behzad-Behbahani
Gold nanoparticles (AuNPs) are commonly used in biosensors of various kinds. However, its application to extract DNA from cancer tissues has not been extensively studied. The purification of DNA from cancer tissues is an important step in diagnostic and therapeutic development. Almost, all cervical cancer cases are associated with high-risk human papillomavirus (HR-HPV) infection. Accurate viral diagnosis
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Highly selective sensor for the detection of Hg2+ ions using homocysteine functionalised quartz crystal microbalance with cross-linked pyridinedicarboxylic acid IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Dinesh Ramkrushna Rotake; Ajay Kumar; Anand D. Darji; Jitendra Singh
This study reports an insightful portable vector network analyser (VNA)-based measurement technique for quick and selective detection of Hg 2+ ions in nanomolar (nM) range using homocysteine (HCys)-functionalised quartz-crystal-microbalance (QCM) with cross-linked-pyridinedicarboxylic acid (PDCA). The excessive exposure to mercury can cause damage to many human organs, such as the brain, lungs, stomach
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Transcriptomic changes in green bean pods against grey mould and white rot diseases via field application of chemical elicitor nanoparticles IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Hoda A.S. El-Garhy; Ahmed A. Elsisi; Shereen A. Mohamed; Osama M. Morsy; Gamal Osman; Fayz A. Abdel-Rahman
The authors tested the efficacy of two salt nanoparticles (NPs), namely, copper dioxide (CuO) and tri-calcium phosphate [Ca 3 (PO 4 ) 2 ] to induce resistance in green bean pods against grey mould and white rot diseases caused by Botrytis cinerea and Sclerotinia sclerotiorum , respectively. High amounts of phytoalexins, kievitone, coumestrol, phaseollidin, 6-ά-hydroxyphaseollin, and phaseollin, were
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CAD/CAM scaffolds for bone tissue engineering: investigation of biocompatibility of selective laser melted lightweight titanium IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Hendrik Naujokat; Johanna Rohwedder; Aydin Gülses; Oral Cenk Aktas; Jörg Wiltfang; Yahya Açil
The objective of the current in-vitro study was to evaluate the biocompatibility of a new type of CAD/CAM scaffold for bone tissue engineering by using human cells. Porous lightweight titanium scaffolds and Bio-Oss® scaffolds as well as their eluates were used for incubation with human osteoblasts, fibroblasts and osteosarcoma cells. The cell viability was assessed by using fluorescein diazo-acetate
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Facile synthesis and application of cellulosic coagulant from banana peels in cadmium-spiked water IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Opeyemi A. Oyewo; Mokgadi F. Bopape; Maurice S. Onyango
Cellulosic coagulant with low crystallinity and surface charge of −19.2 mV were extracted from wet banana peels (WBE) using kitchen-blending method. Functionalization with ferric chloride and aluminium chloride yielded higher surface charge of −23.8 mV (mWBE). Both WBE and mWBE coagulants were used to target cadmium ions from aqueous solution. Coagulants and the floccules (WBEA and mWBEA) were characterized
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Synthesis of surfactant-modified ZIF-8 with controllable microstructures and their drug loading and sustained release behaviour IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Xinyu Xu; Ye Liu; Zhaoming Guo; Xue-Zhi Song; Xiuyu Qi; Zideng Dai; Zhenquan Tan
Metal-organic frameworks (MOFs) as drug carriers have many advantages than traditional drug carriers and have received extensive attention from researchers. However, how to regulate the microstructure of MOFs to improve the efficiency of drug delivery and sustained release behaviour is still a big problem for the clinical application. Herein, the authors synthesise surfactant-modified ZIF-8 nanoparticles
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Effect of receiver shape and volume on the Alzheimer disease for molecular communication via diffusion IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Ibrahim Isik; H. Birkan Yilmaz; Ilker Demirkol; Mehmet Emin Tagluk
Nano-devices are featured to communicate via molecular interaction, the so-called molecular communication (MC). In MC systems, the information is carried by molecules where the amount of molecules constitutes the level of the signal. In this study, an MC-based system was analysed with different receiver topology and related parameters, such as size, shape, and orientation of receptors on the receiver
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Router design for nano-communication using actin quantum cellular automata IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Biplab Das; Debashis De
Logic expressions can be designed from actin filaments. It is a protein that makes the cellular structure and plays an important role in intracellular communication. Nano communication technique has been established using actin cellular automata. Among several rules, (1, 30) and (4, 27) rules have been used to design 2 to 1 multiplexer, 4 to 1 multiplexer, 1 to 2 demultiplexer and 1 to 4 demultiplexer
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Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Şükran Alpdemir; Tayfun Vural; Göknur Kara; Cem Bayram; Erdem Haberal; Emir Baki Denkbaş
This study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised and encapsulated in alginate microspheres together with an antineoplastic agent, sorafenib. In the study, firstly SPIONs were synthesised and characterised by dynamic light scattering, energy-dispersive
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Synthesised magnetic nano-zeolite as a mycotoxins binder to reduce the toxicity of aflatoxins, zearalenone, ochratoxin A, and deoxynivalenol in barley IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Rouhollah Karami-Osboo; Mehdi Maham; Mahmoud Nasrollahzadeh
Agricultural commodities, particularly cereals can be contaminated with mycotoxins during the pre- and post-harvest stage. The main goal of this study was to evaluate the efficacy of magnetic zeolite nanocomposite (MZNC) as an adsorbent for the reduction of mycotoxins in barley flour. The MZNC is synthesised using an eco-friendly and efficient procedure and characterised by zeta potential, field emission
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Synthesis, radiolabelling, and biological assessment of folic acid-conjugated G-3 99mTc-dendrimer as the breast cancer molecular imaging agent IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Saedeh Zamani; Mehdi Shafeie-Ardestani; Ahmad Bitarafan-Rajabi; Ali Khalaj; Omid Sabzevari
Hence, in this study, the authors aimed to develop a dendrimer-based imaging agent comprised of poly(ethylene glycol) (PEG)-citrate, technetium-99 m ( 99m Tc), and folic acid. The dendrimer-G3 was synthesised and conjugated with folic acid, which confirmed by Fourier transform infrared, proton nuclear magnetic resonance, dynamic light scattering, and transition electron microscopy. 2,3-bis-(2-meth
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Encoding scheme for data storage and retrieval on DNA computers IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-10-05 Dolly Sharma; Ranjit Kumar; Mayuri Gupta; Tanisha Saxena
There has been exponential growth in the amount of data being generated on a daily basis. Such a huge amount of data creates a need for efficient data storage techniques. Due to the limitations of existing storage media, new storage solutions have always been of interest. There have been recent developments in order to efficiently use synthetic deoxyribonucleic acid (DNA) for information storage. DNA
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Overcoming the blood-brain barrier in neurodegenerative disorders and brain tumours. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Zahra Ebrahimi,Sam Talaei,Shahin Aghamiri,Nasser Hashemi Goradel,Ali Jafarpour,Babak Negahdari
Drug delivery is one of the major challenges in the treatment of central nervous system disorders. The brain needs to be protected from harmful agents, which are done by the capillary network, the so-called blood–brain barrier (BBB). This protective guard also prevents the delivery of therapeutic agents to the brain and limits the effectiveness of treatment. For this reason, various strategies have
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Integration of Cynodon dactylon and Muraya koenigii plant extracts in amino-functionalised silica-coated magnetic nanoparticle as an effective sorbent for the removal of chromium(VI) metal pollutants. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Dhanya Vishnu,Balaji Dhandapani
Immobilised magnetic nanoparticles are extensively used owing to their superparamagnetic nature, surface interaction, and binding specificity with the appropriate portentous substances. The present research focuses on the development of a portentous, robust carrier, which integrates the silica-coated amino-functionalised magnetic nanoparticle (AF-MnP) with the plant extracts of Cynodon dactylon (L1)
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Antimicrobial activity of functionalised carbon nanotubes against pathogenic microorganisms. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Sahar E Abo-Neima,Hussein A Motaweh,Emad M Elsehly
Carbon nanotubes represent one of the best examples of novel nanostructures, exhibit a range of extraordinary physical properties, strong antimicrobial activity and can pierce bacterial cell walls. This investigation handles the antimicrobial activity of functionalised multiwall carbon nanotubes (F-MWNTs) as an alternative antimicrobial material compared to the commercial antibiotics. Antibacterial
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Functional role of microRNA-500a-3P-loaded liposomes in the treatment of cisplatin-induced AKI. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Suhua Zhang,Huaixin Sun,Weixin Kong,Bo Zhang
Cisplatin treatment results in acute kidney injury (AKI) by the phosphorylation of mixed lineage kinase domain-like protein (MLKL). The knockout of MLKL, which is a principle mediator of necroptosis, is believed to alleviate the AKI symptoms. The present study was aimed to improve the therapeutic efficacy in AKI. For this purpose, miR-500a-3P was identified as appropriate miRNA therapeutics and loaded
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N-acetylcysteine-PLGA nano-conjugate: effects on cellular toxicity and uptake of gadopentate dimeglumine. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Elham Poonaki,Mohammad Esfandyar,Hadi Hejazinia,Seyed Esmaeil Sadat Ebrahimi,Morteza Pirali Hamedani,Jafar Farzaneh,Mehdi Shafiee Ardestani
Gadolinium as a contrast agent in MRI technique combined with DTPA causes contrast induced nephropathy (CIN) and nephrogenic systemic fibrosis (NSF) which can reduce by usage of antioxidants such as N-acetyl cysteine by increasing the membrane's permeability leads to lower cytotoxicity. In this study, N -acetyl cysteine-PLGA Nano-conjugate was synthesized according to stoichiometric rules of molar
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Chitosan nanoparticles loaded with aspirin and 5-fluororacil enable synergistic antitumour activity through the modulation of NF-κB/COX-2 signalling pathway. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Peng Wang,Yaping Shen,Liang Zhao
Based on the enhancement of synergistic antitumour activity to treat cancer and the correlation between inflammation and carcinogenesis, the authors designed chitosan nanoparticles for co-delivery of 5-fluororacil (5-Fu: an as anti-cancer drug) and aspirin (a non-steroidal anti-inflammatory drug) and induced synergistic antitumour activity through the modulation of the nuclear factor kappa B (NF-κB)/cyclooxygenase-2
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Salacia mulbarica leaf extract mediated synthesis of silver nanoparticles for antibacterial and ct-DNA damage via releasing of reactive oxygen species. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Chandra Sekhar Espenti,Kummari Subba Venkata Krishna Rao,Palakurthi Ramesh,Akila Chandra Sekhar,Kummara Madhusudana Rao
In this examination, we researched the advantages of DNA fragmentation and metallic nanoparticles well-appointed with biomolecules. A novel interpretation of DNA damage by Silver Nano-Clusters (AgNCs) which were developed by the utilization of green synthesis method was demonstrated. The green synthesis of AgNCs was accomplished by utilizing the leaf extract of Salacia mulbarica (SM). The preparation
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Investigating conformational changes of Prefoldin β1 as result of applying external mechanical force without any position constraint. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Mohammad Askarian,Reza Hasanzadeh Ghasemi,Majid Moavenian
Manipulating molecular scale bio-nanorobots and influencing their behaviour is one of the major challenges of new researches. Many coiled coil type proteins are involved in important biological functions due to physical properties that make them ideal for both nanoscale manipulation and sensing. The Prefoldin beta subunit from Thermococcus strain KS-1(Prefoldin β1) is one of the possible proteins that
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Design, characterisation and drug release study of polymeric, drug-eluting single layer thin films on the surface of intraocular lenses. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Athanasios Karamitsos,Lampros Lamprogiannis,Varvara Karagkiozaki,Argyrios Laskarakis,Lambrini Papadopoulou,Dimitrios Fatouros,Nikolaos Ziakas,Stergios Logothetidis,Ioannis Tsinopoulos
To design, develop and study a novel drug delivery system for intraocular applications. The spin coating technique was applied to develop a polymeric, drug-eluting thin film consisting of a blend of organic polymers [poly (D, L lactide coglycolide) lactide: glycolide 75: 25, PLGA and polycaprolactone, PCL] and dexamethasone on the surface of intraocular lenses (IOLs). The initial durability of the
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Functionalisation of Fe3O4 nanoparticles by 2-((pyrazol-4-yl) methylene) hydrazinecarbothioamide enhances the apoptosis of human breast cancer MCF-7 cells. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Mohammad Reza Izadpanah,Ali Salehzadeh,Mohammad Zaefizadeh,Mohammad Nikpasand
Cancer is a major cause of death. Thus, the incidence and mortality rate of cancer is globally important. Regarding vast problems caused by chemotherapy drugs, efforts have progressed to find new anti-cancer drugs. Pyrazole derivatives are known as components with anti-cancer properties. In here, Fe 3 O 4 nanoparticles were first functionalized with (3-chloropropyl) trimethoxysilane, then 2-((pyrazol-4-yl)
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Synthesis and comparative assessment of antiradical activity, toxicity, and biodistribution of κ-carrageenan-capped selenium nanoparticles of different size: in vivo and in vitro study. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Marina Lesnichaya,Roman Shendrik,Evgeniy Titov,Boris Sukhov
In the present study, water-soluble hybrid selenium-containing nanocomposites have been synthesised via soft oxidation of selenide-anions, preliminarily generated from elemental bulk-selenium in the base-reduction system ‘N 2 H 4 –NaOH’. The nanocomposites obtained consist of Se 0 NPs (4.6–24.5 nm) stabilised by κ-carrageenan biocompatible polysaccharide. The structure of these composite nanomaterials
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Recyclable adsorbents based on Fe3O4 nanoparticles on lanthanum-modified montmorillonite for the efficient phosphate removal. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-08-06 Yi Zhang,Fengzhen Zhou,Wenjing Wang,Huiling Guo,Mingxing Liu,Hongda Zhu,Hongmei Sun
Montmorillonite (MMT) clay modified with lanthanum (La) ions and Fe 3 O 4 nanoparticles was proposed for the effective removal of phosphate ions from aqueous solution. Characterisation of the adsorbent using FTIR, SEM, XRD, XPS, XRF, BET and VSM techniques were carried out. The effects of initial phosphate concentration, contact time, dosage and pH on the phosphorus adsorption were investigated. La-MMT/Fe
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Improving performance of neurons by adding colour noise. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Keyvan Aghababaiyan
Noise is not always an interfering signal which perturbs the system. On the contrary, noise signals can enhance the performance of some non-linear systems such as stochastic resonance (SR). These systems can detect the weak input signal when it is added to the noise signal. According to this property, SR models play a significant role in the functioning of the brain for detecting weak input signals
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Iron oxide/gold nanoparticles-decorated reduced graphene oxide nanohybrid as the thermo-radiotherapy agent. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Kave Moloudi,Hadi Samadian,Mehdi Jaymand,Ehsan Khodamoradi,Mojtaba Hoseini-Ghahfarokhi,Farshid Fathi
The main focus of the current study is the fabrication of a multifunctional nanohybrid based on graphene oxide (GO)/iron oxide/gold nanoparticles (NPs) as the combinatorial cancer treatment agent. Gold and iron oxide NPs formed on the GONPs via the in situ synthesis approach. The characterisations showed that gold and iron oxide NPs formed onto the GO. Cell toxicity assessment revealed that the fabricated
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Postponement growth and antioxidative response of Brassica nigra on CuO and ZnO nanoparticles exposure under soil conditions. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Riaz Ur Rehman,Bakhtawar Khan,Tehmina Aziz,Faiza Zareen Gul,Syeda Nasreen,Muhammad Zia
Due to unique physiochemical properties, nanoparticles (NPs) have acquired substantial attention in the field of research. However, threats of ecotoxicity and phytotoxicity have limited their biological applications. In this study in vivo experiments were performed to determine the effect of CuO (12.5, 25 and 50 mg/kg) and ZnO (200, 400 and 600 mg/kg) NPs on growth, and antioxidant activities of Brassica
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Polyacrylamide-punicic acid conjugate-based micelles for flutamide delivery in PC3 cells of prostate cancer: synthesis, characterisation and cytotoxicity studies. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Razieh Mirsafaei,Jaleh Varshosaz
The aim of the present study was to synthesize a novel biopolymeric micelle based on punicic acid (PA) and polyacrylamide (PAM) for carrying chemotherapeutic drugs used in prostate cancer treatment. A polymer composite micelle was prepared by chemical conjugation between PAM and PA. The micelles were prepared by self-assembly via film casting followed by ultrasonication method. The successful production
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Fabrication of antibacterial sponge cleaner using gold nanoclusters. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Pengfei Zhuang,Kuo Li,Kun Qian,Dan Li,Xifan Mei
From the dinner table to the office, many surfaces contain bacteria and the threat to human health. In this work, cost-effective antimicrobial foams were developed by the adsorption of lysozyme protected gold nanoclusters (AuNCs) in sponges. Antibacterial activities of the prepared antibacterial AuNCs were evaluated using typical Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria
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Hepatic histopathological and ultrastructural alterations induced by 10 nm silver nanoparticles. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Amin Al-Doaiss,Qais Jarrar,Said Moshawih
Silver nanoparticles (Ag NPs) are invested in various sectors and are becoming more persistent in our ambient environment with potential risk on our health and the ecosystems. The current study aims to investigate the histological, histochemical and ultrastructural hepatic changes that might be induced by 10 nm silver nanomaterials. Male mice (BALB/C) were exposed for 35 injections of daily dose of
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Superparamagnetic cobalt ferrite nanoparticles as T2 contrast agent in MRI: in vitro study. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Zahra Mohammadi,Neda Attaran,Ameneh Sazgarnia,Seyed Ali Mousavi Shaegh,Alireza Montazerabadi
Superparamagnetic cobalt ferrite nanoparticles (CoFe2O4) possess favourite advantages for theranostic applications. Most of previous studies reported that CoFe2O4 magnetic nanoparticles (MNPs) are suitable candidates for induction of hyperthermia and transfection agents for drug delivery. The present study synthesized and investigated the potential use of CoFe2O4 as a contrast agent in magnetic resonance
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Relative larvicidal property of common oxide nanostructures against Culex quinquefasciatus. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Adrita Chakrabarti,Prasun Patra
Common oxide nanostructures such as silicon-di-oxide, magnesium-oxide, zinc-oxide, and copper-oxide (CuO) having useful functional and bioactive properties have been synthesised and characterised. All these nanostructures have been found to be larvicidal towards Culex quinquefasciatus mosquito especially against lower instars in comparison with higher instars in 48 h. Only, CuO is larvicidal against
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Tomato response to metal nanoparticles introduction into the nutrient medium. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Yu Chen,Jinying Lu,Min Liu,Huasheng Li,Qiao Sun,Galina S Nechitaylo,Olga A Bogoslovskaya,Irina P Olkhovskaya,Natalya N Glushchenko
This study is aimed to explore the capacity of metal nanoparticles (NPs) iron, zinc, copper and their combinations introduced in the Murashige-Skoog (MS) nutrient medium (NM) to affect the growth and development of tomato plants (Solanum lycopersicum L.). NPs were prepared by a flow-levitation method. Metal NPs were characterised by transmission and scanning electron microscopy, X-ray phase analysis
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Inhibitory effect of magnetic iron-oxide nanoparticles on the pattern of expression of lanosterol 14α-demethylase (ERG11) in fluconazole-resistant colonising isolate of Candida albicans. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Mohammad Zare-Khafri,Fahimeh Alizadeh,Sadegh Nouripour-Sisakht,Alireza Khodavandi,Majid Gerami
Fluconazole-resistant Candida albicans is a big scary reality. The authors assessed the antifungal effects of magnetic iron-oxide nanoparticles on fluconazole-resistant colonising isolate of C. albicans and determined the expression of ERG11 gene, protein sequence similarity and ergosterol content. C. albicans isolates were characterised and fluconazole resistance is recognised using World Health Organization's
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In vivo study of anti-epidermal growth factor receptor antibody-based iron oxide nanoparticles (anti-EGFR-SPIONs) as a novel MR imaging contrast agent for lung cancer (LLC1) cells detection. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Daryoush Shahbazi-Gahrouei,Negar Abdi,Saghar Shahbazi-Gahrouei,Seyed Hossein Hejazi,Zeinab Salehnia
Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anti-epidermal growth factor receptor monoclonal antibody (anti-EGFR-SPIONs) were characterised, and its cytotoxicity effects, ex vivo and in vivo studies on Lewis lung carcinoma (LLC1) cells in C57BL/6 mice were investigated. The broadband at 679.96 cm-1 relates to Fe-O, which verified the formation of the anti-EGFR-Mab with SPIONs
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Fabrication, calibration, and preliminary testing of microcantilever-based piezoresistive sensor for BioMEMS applications. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Dinesh Rotake,Anand Darji,Nitin Kale
In this study, the authors demonstrate the fabrication, calibration, and testing of a piezoresistive microcantilever-based sensor for biomedical microelectromechanical system (BioMEMS) application. To use any sensor in BioMEMS application requires surface modification to capture the targeted biomolecules. The surface alteration comprises self-assembled monolayer (SAM) formation on gold (Au)/chromium
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Upconversion nanotubes with tunable fluorescence properties based on Gd2O2S:Ln3+ (Ln3+ = Yb3+, Er3+) and derivatives for photodynamic therapy. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-07-01 Mei Yang,Qingyuan Gui,Jinlei Ma,Lei Qi,Bijun Bao,Yida Huang
In this study, Gd2O2S:Ln3+ (Ln3+ = Yb3+, Er3+) upconversion nanotubes (UCNTs) were synthesised by using Gd(OH)3:Ln3+ (Ln3+ = Yb3+, Er3+) nanotubes as the template. The luminescent and biological properties of Gd2O2S:Ln3+ (Ln3+ = Yb3+, Er3+) UCNTs, along with photodynamic therapy (PDT) applications of the Gd2O2S:8%Yb3+,2%Er3+ UCNT-Ce6 (chlorin e6) nanocomposites, were systematically studied. The resultant
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Sialic acid-conjugated PLGA nanoparticles enhance the protective effect of lycopene in chemotherapeutic drug-induced kidney injury. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-06-01 Gong Xiao,Junlin Zou,Xiangcheng Xiao
Lycopene (LYC) is known to protect cells from oxidative damage caused by free radicals in human tissues. In the present study, the authors designed a LYC-loaded sialic acid (SA)-conjugated poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle (LYC-NP) to enhance the therapeutic efficacy of LYC in acute kidney injury. The characteristics of the LYC-NPs were defined according to particle size, morphology
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Analytical study of biosynthesised silver nanoparticles against multi-drug resistant biofilm-forming pathogens. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-06-01 Wafa Badar,Muhammad Azmat Ullah Khan
The emergence of the huge number of multi-drug resistant (MDR) bacteria requires an alternative to the drugs. Silver nanoparticles (AgNPs) are a strong candidate for this due to their bactericidal properties, which can be better concluded by understanding their morphology and chemistry. The study hypothesised that AgNPs synthesised using leaves of Syzygium cumini can be used to treat locally emerging
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Biosynthesis of Ag nanoparticles and two-dimensional element distribution in Arabidopsis. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-06-01 Huanhuan Xu,Tao Yu,Ying Fu,Zhiyan Dang,Li Wang,Songhai Xie,Fang Chang,Hao Shen,Qingguang Ren
Metallic nanoparticles can be synthesised in living plants, which provide a friendly approach. In this work, the authors aimed to study the synthesis of silver nanoparticles (AgNPs) in Arabidopsis and the two-dimensional (2D) distribution of Ag and other elements (Ca, P, S, Mg, and CI) in the Arabidopsis plant tissues. The concentrations of Ag in the plant tissues were determined by inductively coupled
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Assessment of in-vivo biocompatibility evaluation of phytogenic gold nanoparticles on Wistar albino male rats. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-06-01 Balashanmugam Pannerselvam,Vidya Devanathadesikan,Tamil Selvi Alagumuthu,Swarna V Kanth,Kalaichelvan Pudupalayam Thangavelu
Nanomedicine is an interdisciplinary approach that involves toxicology and other medicinal applications. Gold nanoparticles (AuNPs) may serve as a promising model to address the size and shape-dependent biological response because they show good biocompatibility. This study is to prepare phytosynthesis AuNPs from ten different Cassia sp. Among them, the aqueous leaf extract of C. roxburghii produced
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Studies on binding of single-stranded DNA with reduced graphene oxide-silver nanocomposites. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-06-01 Xi Li,Linqing Yang,Yunfei Wang,Zhongyu Du,Xuyan Mao,Dezhi Sun,Jun Liu,Yu Zhou,Xiangyu Xu
The binding reaction of reduced graphene oxide-silver nanocomposites (rGO-AgNCs) with calf thymus single-stranded DNA (ssDNA) was studied by ultraviolet-visible absorption, fluorescence spectroscopy and circular dichroism (CD), using berberine hemisulphate (BR) dye as a fluorescence probe. The absorbance of ssDNA increases, but the fluorescence intensity is quenched with the addition of rGO-AgNCs.
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Synthesis and characterisation of LiB3O5 nanophosphor as a TL dosimeter. IET Nanobiotechnol. (IF 1.859) Pub Date : 2020-06-01 Parvin Kaviani,Daryoush Shahbazi-Gahrouei,Akbar Abdi Saray
In this work, lithium triborate (LiB3O5) nanophosphor was synthesised by precipitation assisted high-temperature solid-state method followed by heating at different sintering temperatures. Then, its crystal structure and morphology were fully characterised. LiB3O5 was doped with different concentrations of different dopants. To determine the thermoluminescence (TL) properties and structural specifications