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New approaches to second-degree burn healing: Polyvinyl alcohol membrane loaded to arnica combined to laser therapy J. Biomater. Appl. (IF 2.9) Pub Date : 2024-03-12 Carolina Silva Cardoso, Filipe Feitosa de Carvalho, Rodrigo César Gomes, Reinaldo José Gianini, Camilla Fanelli, Irene de Lourdes Noronha, Nelson Brancaccio dos Santos, Daniel Komatsu, Priscila Randazzo-Moura
Second-degree burns require greater care, as the damage is more extensive and worrisome and the use of a biomaterial can help in the cell repair process, with better planning, low cost, and better accessibility. Arnica has anti-inflammatory and analgesic properties in skin lesions treatments and laser therapy is another therapeutic alternative for burns. Evaluate the effects of arnica incorporated
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The effect of Bletilla striata polysaccharide on the physical and healing properties of curdlan-based hydrogel for wound healing J. Biomater. Appl. (IF 2.9) Pub Date : 2024-03-11 Jin Shang, Liangliang Duan, Weimin Zhang, Qibin Zhuang, Xiaomei Ren, Dale Gu
Bletilla striata polysaccharide (BSP) was added to curdlan to form a blend hydrogel through a simple heating-cooling procedure to improve the hydrophilicity and healing efficacy of curdlan-based hydrogel used in wound healing. We explored the interplay between BSP and curdlan, studied how BSP concentration affects the physical properties and microstructures of hydrogels, and examined the biocompatibility
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Assessing the efficacy of curcumin-loaded alginate hydrogel on skin wound healing: A gene expression analysis J. Biomater. Appl. (IF 2.9) Pub Date : 2024-03-08 Sepehr Zamani, Majid Salehi, Arian Ehterami, Mh Busra Fauzi, Ghasem Abbaszadeh-Goudarzi
Skin tissue engineering has gained significant attention as a promising alternative to traditional treatments for skin injuries. In this study, we developed 3D hydrogel-based scaffolds, Alginate, incorporating different concentrations of Curcumin and evaluated their properties, including morphology, swelling behavior, weight loss, as well as hemo- and cytocompatibility. Furthermore, we investigated
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Morin loaded mesoporous molecular sieves as novel devices to the potential treatment of tumor pathologies J. Biomater. Appl. (IF 2.9) Pub Date : 2024-03-08 María Gabriela Montiel Schneider, María Julia Martín, Natalia Cuello, María Florencia Favatela, Claudia Gentili, Verónica Elias, Griselda Eimer, Verónica Lassalle
Morin is an antioxidant and anticancer flavonoid, extracted from natural sources, that may exert beneficial effects for several pathologies. Despite this, the administration of morin represents a challenge due to its low aqueous solubility. Mesoporous silica materials have emerged as biocompatible tools for drug delivery, as their pore size can be modulated for maximum surface area to volume ratio
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Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy J. Biomater. Appl. (IF 2.9) Pub Date : 2024-03-01 Chao Zhong, Xiufeng Zhang, Yanfang Sun, Zhong Shen, Yanan Mao, Tianqi Liu, Rui Wang, Lei Nie, Amin Shavandi, Khaydar E Yunusov, Guohua Jiang
In this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly (1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VA)) as matrix materials were developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment. In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were
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Impact of topography and added TiN-coating on adult human dermal fibroblasts after seeding on titanium surface in-vitro J. Biomater. Appl. (IF 2.9) Pub Date : 2024-02-15 G. Hauschild, J. Hardes, M. Dudda, A. Streitbürger, M. Wahrenburg
Complications of transcutaneous osseointegrated prosthetic systems (TOPS) focus on the metal-cutaneous interface at the stoma. Besides pain due to scare tissue as well as undefined neuropathic disorders, there is high evidence that the stoma presents the main risk causing hypergranulation and ascending infection. To restore the cutaneous barrier function in this functional area, soft-tissue on- or
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Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing J. Biomater. Appl. (IF 2.9) Pub Date : 2024-02-12 Yeasmin Akter, Md Minhajul Islam, Md Shamim Akter, Khodeja Afrin, Md Saiful Alam, Papia Haque, Newaz Mohammed Bahadur
Multifunctional and biodegradable dressings with high mechanical strength and good antibacterial activity are crucial in fundamental health services. This study was initiated to prepare a novel curative wound dressing film consisting of natural biodegradable gelatin (G) and polylactic acid (PLA) with silver nanoparticles (AgNPs) where glutaraldehyde (GA) was used as compatibilizer. The prepared composite
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A cancer cell nanotherapy method based on GHz film bulk acoustic resonator and nanoscale CaO2 J. Biomater. Appl. (IF 2.9) Pub Date : 2024-02-06 Zhichao Liu, Yulun Nie, Shuo Wang, Chengliang Sun, Yao Cai, Sheng Liu
Sonodynamic therapy (SDT) is an emerging cancer treatment method in recent years. However, the ultrasound signal utilized for SDT is usually located at a low-frequency spectrum (<2 MHz), and in the field of SDT research, few studies have focused on the exploration and development of ultrasound frequency. Studies have shown that the GHz-level ultrasound can increase cell membrane permeability and have
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ThermOxshield ion pair self assembly unleashing suppressed release J. Biomater. Appl. (IF 2.9) Pub Date : 2024-01-29 Yuyuan Guo, Jomon George Joy, Jin-Chul Kim
Poly (acrylic acid) (PAA), an anionic polymer was used to prepare ion pair self-assembly (IPSAM) with 4-(methylthio)aniline (MTA), a hydrophobic counter ion, which is responsive to temperature and oxidation. The IPSAM was formed when the carboxylic to amino group molar ratio was 7/3-5/5. The structure of the IPSAM nanoparticle was spherical whose diameter was 30-40 nm on the TEM images. The PAA/MTA
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Controlled pore anisotropy in chitosan-gelatin cryogels for use in bone tissue engineering J. Biomater. Appl. (IF 2.9) Pub Date : 2024-01-27 Madeline Andres, Eileen Robertson, Andrew Hall, Sarah McBride-Gagyi, Scott Sell
In tissue engineering, the development of an appropriate scaffold is crucial to provide a framework for new tissue growth. The use of cryogels as scaffolds shows promise due to their macroporous structure, but the pore size, distribution, and interconnectivity is highly variable depending on the fabrication process. The objective of the current research is to provide a technique for controlled anisotropy
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Fabrication and evaluation of silver modified micro/nano structured titanium implant J. Biomater. Appl. (IF 2.9) Pub Date : 2024-01-24 Chengyi Huang, Haiyan Wang, Lili Yao, Li Li, Weiwei Lou, Litao Yao, Yitian Shi, Renren Li
In order to enhance the antibacterial property of titanium implant without inducing obvious cytotoxicity, the combination of Ag nanolayer and micro/nano surface structure was conducted by magnetron sputtering and hot-alkali treatment in this study. A series of specimens (AH-Ti, AH-Ti/Ag0.25, AH-Ti/Ag1, AH-Ti/Ag2, and AH-Ti/Ag5) were prepared with different sputtering durations (0 min, 0.25 min, 1 min
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Alginate microspheres encapsulating hox transcript antisense RNA siRNA regulate the Hedgehog-Gli1 pathway to alleviate epidermal growth factor receptor tyrosine kinase inhibitors resistance J. Biomater. Appl. (IF 2.9) Pub Date : 2024-01-23 Guojie Lu, Huiling Zhong, Jianwei Gao, Yaosen Zhang
The long non-coding RNA HOTAIR and the Hedgehog-Gli1 signaling pathway are closely associated with tumor occurrence and drug resistance in various cancers. However, their specific roles in the development of EGFR-TKIs resistance in non-small cell carcinoma remain unclear. To address the issue of EGFR-TKIs resistance, this study utilized the electrospray method to prepare sodium alginate microspheres
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Investigating temperature variability on antioxidative behavior of synthesized cerium oxide nanoparticle for potential biomedical application J. Biomater. Appl. (IF 2.9) Pub Date : 2024-01-04 Shivam Pandey, Sneha Kumari, Leela Manohar Aeshala, Sushant Singh
Cerium oxide nanoparticles (CNP) have garnered significant attention due to their versatile redox properties and wound-healing applications. The antioxidative nature of CNP is due to its ability to be oxidized and reduced, followed by the capture or release of oxygen which is used for scavenging reactive oxygen species (ROS). Herein, CNP is produced through a wet chemistry approach and its tunable
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Omental coating attenuates implant-induced foreign body reaction in rats J. Biomater. Appl. (IF 2.9) Pub Date : 2024-01-02 Haonan Guan, Xinyi Lu, Di Zhang, Jiajun Tang, Jiaoyun Dong, Guoyou Zhang, Jie Lian, Shuliang Lu
The objective of this study is to clarify whether the omental coating can effectively attenuate foreign body reaction (FBR) induced by implanted materials. Male Sprague-Dawley rats were injected with polydextran particle slurry intraperitoneally to activate the omentum. 7 days later, polyether polyurethane sponge discs were implanted subcutaneously on each side of the rat’s back as the foreign implants
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Radiation processing of bacterial cellulose-monolaurin wound dressing: Physicochemical effects, functional analysis, and sterilization. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-30 Charito Tranquilan-Aranilla,Jeric Flores,Alvin Kier Gallardo,Gina Abrera,Franklin Pares
A commercial bacterial cellulose-monolaurin wound dressing was investigated for changes in the chemical structure, mechanical strength, thermal degradation, morphology, and functional swelling properties after exposure to gamma and electron beam radiations at doses 15-50 kGy. Radiation-induced oxidation occurred as seen in the FT-IR peaks at 1720-1750 cm-1. Degradation of the cellulosic network was
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Novel dual targeting cubosomes modified with angiopep-2 for co-delivery GNA and PLHSpT to brain glioma. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-24 Tongyuan Lin,Qing Wei,Huamin Zhang,Yong Yang,Bo Jiang,Zhangyi Wang,Siyuan Li,Qiang Wang,Mengru Hu,Weidong Chen,Lei Wang,Baijing Ding
3Glioblastoma multiforme is the most aggressive malignant brain tumor. However, the treatment of glioblastoma multiforme faces great challenges owing to difficult penetration of the blood-brain barrier. Therefore, more effective treatment strategies are desired quite urgently. In our study, a dual-targeting drug delivery system for co-loading with hydrophobic Gambogenic acid and hydrophilic PLHSpT
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Thermoplastic polyurethane surface coated with polymer brushes for reduced protein and cell attachment. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-14 Rashed Almousa,Dong Xie,Yong Chen,Jiliang Li,Gregory G Anderson
The objective of this study was to coat negatively charged polymer brushes covalently onto the surface of thermoplastic polyurethane (TPU) using a simple conventional surface free-radical polymerization technique. The coated surfaces were assessed with contact angle, protein adsorption, cell adhesion and bacterial adhesion. Bovine serum albumin (BSA) and bovine fibrinogen (BFG) were used for protein
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3D printed Si-CaP scaffold released SiO32- and Ca2+ to synergistically promote angiogenesis. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-14 Yongqiang Mo,Weitao He,Shiqi Hu,Hongchun Guo,Shuangzuo Li,Jingwei Zhang,Xintao Wang
BACKGROUND AND PURPOSE Structuring scaffold with both osteogenic and angiogenesis capabilities is a challenge for bone tissue engineering. Powder structured Si-CaP materials have shown excellent osteogenic properties and induction of stem cell differentiation. Our research group have successful produced 3D printed Si-CaP scaffolds by DLP technology. This study aims to explore the angiogenic effects
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Polyamidoamine dendrimer-mediated hydrogel for solubility enhancement and anti-cancer drug delivery. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-07 Xiangdong Bi,Darra B Watts,Ian Dorman,Casianna M Kirk,Marisa Thomas,Isaiah Singleton,Colleen Malcom,Taylor Barnes,Colby Carter,Aiye Liang
The application of hydrogels for anti-cancer drug delivery has garnered considerable interest in the medical field. Current cancer treatment approaches, such as chemotherapy and radiation therapy, often induce severe side effects, causing significant distress and substantial health complications to patients. Hydrogels present an appealing solution as they can be precisely injected into specific sites
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Imperfect cross-linking of xanthan for pH-responsive bio-based composite moist wound dressings by stencil printing. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-06 Florian Wurm,Margit Lenninger,Astrid Mayr,Cornelia Lass-Floerl,Tung Pham,Thomas Bechtold
The work addresses the use of bio-based and -degradable materials for the production of a moist, adaptive and anti-microbial wound dressing. The dressing is targeted to exhibit a pH-dependent active agent release. Xanthan hydrogel structures are coated on cellulose fabrics via stencil printing and subsequently cross-linked using glyoxal. By alteration of the cross-linker content from 1 to 6% by mass
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Electrospun poly (ε-caprolactone)/beeswax based super-hydrophobic anti-adhesive nanofibers as physical barriers for impeding fibroblasts invasion. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-05 B Sowmya,Prasanta Kumar Panda
Super-hydrophobic electrospun membranes are very essential barrier materials to physically isolate the wound site in order to prevent adhesions and for restoring the normal functioning of the surrounding tissues and organs. In the present study, poly (ε-caprolactone) (PCL)/beeswax (BW) based nanofibrous anti-adhesion membranes were fabricated by electrospinning technique. The BW concentration was varied
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Nano-injectable pH/NIR-responsive hydrogel for chemo-photothermal synergistic drug delivery. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-02 Qian Zhao,Xu Yue,Liu Miaomiao,Wang Yanming,Guolin Wu
Conventional cancer treatments are highly toxic and ineffective; therefore, it is essential to develop less toxic and minimally invasive treatment methods. A pH/Near Infra-red (NIR) dual-responsive, nano-injectable smart hydrogel was fabricated by incorporating CuS nanoparticles into the hydrogel networks formed by a random copolymer of N-isopropylacrylamide (NIPAM) and double-bond functionalized uracil
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Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-11-01 Golara Kafili,Hannaneh Kabir,Amirhossein Jalali Kandeloos,Elham Golafshan,Sara Ghasemi,Shohreh Mashayekhan,Nayere Taebnia
Despite the advent of tissue engineering (TE) for the remodeling, restoring, and replacing damaged cardiovascular tissues, the progress is hindered by the optimal mechanical and chemical properties required to induce cardiac tissue-specific cellular behaviors including migration, adhesion, proliferation, and differentiation. Cardiac extracellular matrix (ECM) consists of numerous structural and functional
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Development of Ag NPs/allantoin loaded PCL/GEL electrospun nanofibers for topical wound treatment. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-10-31 Mohsen Doostmohammadi,Seyyed Vahid Niknezhad,Hamid Forootanfar,Younes Ghasemi,Elham Jafari,Mahboubeh Adeli-Sardou,Armin Amirsadeghi,Alieh Ameri
In the present study, the allantoin and silver nanoparticle (Ag NPs) loaded poly caprolactone/gelatin (PCL/GEL) nanofibers produced using electrospinning technique and their cyto-compatibility and wound healing activity were evaluated in vitro and in vivo. The SEM imaging revealed diameters of 278.8 ± 10 and 240.6 ± 12 nm for PCL/GEL/Ag NPs and PCL/GEL/Ag NPs/allantoin scaffolds. The Ag NPs entrapment
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Silk fibroin nanoparticles and β-tricalcium phosphate loaded tissue engineered gelatin bone scaffolds: A Nature-based, low-cost solution. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-10-27 Ayşegül Yıldız,Mehmet Birer,Yağmur Turgut Birer,Recep Uyar,Begüm Yurdakök-Dikmen,Füsun Acartürk
Tissue engineering has recently attracted attention as an alternative to traditional treatment methods for tissue and organ damage. Since bone is one of the most important vital parts of the body, the treatment of bone damage is important. Silk fibroin is a natural polymer with properties such as biocompatibility and biodegradability, which attracts attention with its controlled release, especially
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Potential of thermoresponsive hydrogel as an alternative therapy for rat knee osteoarthritis. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-10-22 Yi Kung,Wei-Chun Chien,Hsin-Hsin Shen,Sen-Lu Chen,Wei-Lin Yu,Yu-Chi Wang,Wen-Shiang Chen,Chueh-Hung Wu
Osteoarthritis is a degenerative condition that is highly prevalent and primarily affects the joints. The knee is the most commonly affected site, impacting the lives of over 300 million individuals worldwide. This study presents a potential solution to address the unmet need for a minimally invasive technique in the treatment of osteoarthritis: a biocompatible, injectable, and thermoresponsive hydrogel
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A preliminary In Vitro viability study of an electrically active hernia mesh on mouse fibroblasts. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-10-20 Victoria Drapal,Savannah Mosier,Anna Norman,German Berbel,Jennifer L Robinson,Elizabeth A Friis
Hernias occur when part of an organ, typically the intestines, protrudes through a disruption of the fascia in the abdominal wall, leading to patient pain, discomfort, and surgical intervention. Over one million hernia repair surgeries occur annually in the USA, but globally, hernia surgeries can exceed 20 million. Standard practice includes hernia repair mesh to help hold the compromised tissue together
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The efficiency of fabricated Ag/ZnO nanocomposite using Ruta chalepensis L. leaf extract as a potent protoscolicidal and anti-hydatid cysts agent. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-10-16 Parwin J Jalil,Bushra H Shnawa,Samir M Hamad,Bnar Shahab Hamad,Mukhtar H Ahmed
BACKGROUND As a consequence of their eco-friendliness, simplicity and non-toxicity, the fabrication of metal and metal oxide nanoparticles using greener chemistry has been a highly attractive research area over the last decade. AIM In this study focused on the fabrication of silver-Zinc oxide nanocomposite (Ag-ZnO NCs) using Ruta chalepensis leaf extract and evaluating its potential biological activities
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Proliferation and differentiation of MC3T3-E1 cells on polymethyl methacrylate cements containing Fe3O4 and TiO2 for hyperthermic treatment of metastatic bone tumors. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-10-09 Moe Kubota,Maiko Furuya,Kotone Yokota,Hiroyasu Kanetaka,Tomoyuki Ogawa,Shin Saito,Balachandran Jeyadevan,Masaya Shimabukuro,Taishi Yokoi,Masakazu Kawashita
Polymethyl methacrylate (PMMA) bone cement is widely used to relieve pain caused by metastatic bone tumors. We previously found that PMMA bone cement containing 15 mass% or more of TiO2 showed good apatite-forming ability, and 25 mass% or more of Fe3O4 generated sufficient heat for hyperthermia under an alternating current (AC) magnetic field. In this study, the cytocompatibility of PMMA bone cement
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Additive manufacture of PLLA scaffolds reinforced with graphene oxide nano-particles via digital light processing (DLP). J. Biomater. Appl. (IF 2.9) Pub Date : 2023-10-08 Omid Kordi,Amir Hossein Behravesh,Sadegh Hasannia,Seyyed Kaveh Hedayati,Majid Pourghaumi,Mohammad Mazdi,Iman Ghaderi,Ghaus Rizvi
In this study, 3D printing of poly-l-lactic acid (PLLA) scaffolds reinforced with graphene oxide (GO) nanoparticles via Digital Light Processing (DLP) was investigated to mimic bone tissue. Stereolithography is one of the most accurate additive manufacturing methods, but the dominant available materials used in this method are toxic. In this research, a biocompatible resin (PLLA) was synthetized and
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Simple and biodegradable mesoporous silica nanocarriers for enhancing antitumor therapy through photochemical synergism. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-10-01 Yiping Yang,Yuchang Qin,Shengchao Yang,Tianyu Liu,Enrico Benassi,Lin Cui,Zhiyong Liu,Xuhong Guo,Yongsheng Li
The biosafety and degradability of nanocarriers have always been an important factor restricting their entry into the clinic. In this work, a new nano-system was prepared by coating the photothermal effect of dopamine-doped mesoporous silica nanoparticles with carboxymethyl chitin through electrostatic interaction, and is further anchored with folic acid on the surface for targeted delivery of anti-cancer
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Effect of adipose-derived stem cells seeding and surgical prefabrication on composite scaffold vascularization. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-09-21 Tomasz Debski,Katarzyna Siennicka,Joanna Idaszek,Bartlomiej Roszkowski,Wojciech Swieszkowski,Zygmunt Pojda
The study aimed to evaluate an angiogenic effect of adipose-derived stem cells (ASCs) seeding and surgical prefabrication (placing a vascular pedicle inside the scaffold) on developed composite scaffolds made of poly-ε-caprolactone (PCL), β-tricalcium phosphate (β-TCP), and poly (lactic-co-glycolic acid) (PLGA) (PCL+β-TCP+PLGA). Moreover, we aimed to compare our data with previously tested PCL scaffolds
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Nanogel enhances the efficacy of MLN8237 in treating hepatocellular carcinoma. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-09-11 Wei Gao,Rongxing Shen
MLN8237, a specific inhibitor of Aurora-A kinase, is proved to be a potential treatment strategy for hepatocellular carcinoma (HCC). Nanogels improve the efficacy of doxorubicin. Therefore, this study aims to investigate the increase in the effect of nanogels on MLN8237 in inhibiting HCC. Doxorubicin or MLN8237 was used as an anti-tumor drug models which were packaged by organic solvent volatilization
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Preparation and performance of electrically conductive decellularized nerve matrix hydrogel conduits. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-09-05 Shiyun Yin,Jiangyi Zhou,Jinsong Wang,Bin Xia,Guobao Chen
Peripheral nerve injury (PNI) is one of the major clinical treatment challenges following an impact on the body. When PNI manifests as nerve gaps, surgical connections and exogenous grafts are required. Recently, electrically conductive polymers (CPs) based nerve guidance conduits have yielded promising results for treating PNI. Polypyrrole (PPy) has become one of the most commonly used CPs in PNI
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Efficacy of positive space acquiring membrane and antimicrobial membrane combined with granular bone substitute implantation in guiding oral bone regeneration. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-09-04 Chuanlan Qin,Tongyan Ren,Yiming Liu,Huaying Shao,Fanglin Mi,Bing Wang
Augmentation of the alveolar bone is important before oral implantation. For large bone defects, it becomes necessary to apply guided bone regeneration (GBR) materials, accompanied by filling defect sites with autologous or allogeneic bone, or bone substitutes such as acellular bone powder. In this study, we tested a granular bone substitute and GBR membrane combination therapy in treating MC3T3-E1
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Chrysin loaded bilosomes improve the hepatoprotective effects of chrysin against CCl4 induced hepatotoxicity in mice. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-25 Atefeh Naseri,Somayeh Taymouri,Ali Hosseini Sharifabadi,Jaleh Varshosaz
In the present work, chrysin loaded bilosomes were formulated, characterized and evaluated to enhance the hepatoprotective activity of drug. Accordingly, chrysin loaded bilosomes were prepared by applying the thin film hydration method; also, fractional factorial design was used to optimize the production conditions of nanoformulations. The prepared formulations were subjected to different methods
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Preparation, characterization, and in vivo evaluation of glycyrrhetinic acid-mediated nano-drug delivery system co-loaded with syringopicroside and hydroxytyrosol. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-25 QingXia Guan,Ying Li,Jialin Sun,Weibing Zhang,Xue Zhang,Yumeng Liu,XiaoYing Zhou,XiuYan Li
This study aimed to create a glycyrrhetinic acid (GA)-mediated, multi-component, self-assembled nano-drug delivery system co-loaded with syringopicroside (S) and hydroxytyrosol (H) obtained from Syringa Linn by synthesizing a GA-polyethylene glycol-poly (lactic acid-co-glycolic acid) (GPP) nanoparticle delivery carrier to actively target the liver. The nanoparticles were optimized using the central
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Triple-layered scaffold containing cisplatin and curcumin applied for cancerous bone regeneration. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-24 Nicha Thepsri,Jasadee Kaewsrichan
Novel drug delivery system was prepared and evaluated as for application in cancerous bone treatment. It had three stacked layers, including a drug-free layer, a cisplatin-loaded layer, and a curcumin-containing layer. Our previously characterized biomaterials, namely Zr-hydroxyapatite (Zr-HA) and alkaline-treated polycaprolactone (modified-PCL), were used as major components of the drug carrier. Polar-polar
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VEGF-modified PLA/HA nanocomposite fibrous membrane for cranial defect repair in rats. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-23 Yanghao Wang,Haohan Li,Cuicui Zhao,Qihan Zi,Fei He,Weizhou Wang
A major obstacle to bone tissue repair is the difficulty in establishing a rapid blood supply areas of bone defects. Vascular endothelial growth factor (VEGF)-infused tissue-engineered scaffolds offer a possible therapeutic option for these types of injuries. Their role is to accelerate angiogenesis and improve bone healing. In this study, we used electrostatic spinning and biofactor binding to construct
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Selenium- and/or copper-substituted hydroxyapatite: A bioceramic substrate for biomedical applications. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-21 Sara I Korowash,Zalike Keskin-Erdogan,Bahaa A Hemdan,Lady V Barrios Silva,Doreya M Ibrahim,David Ys Chau
Atomic substitution or doping of a bioceramic material hydroxyapatite (HA) with specific ions is an appealing approach for improving its biocompatibility and activity, as well as imparting antibacterial properties. In this study, selenium- and/or copper-substituted hydroxyapatite powders were synthesized by an aqueous precipitation method and using the freeze-drying technique. The molar concentrations
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Bletilla striata composite nanofibrous membranes prepared by emulsion electrospinning for enhanced healing of diabetic wounds. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-20 Kai Zhao,Zhengbo Hu,Mingyuan Zhou,Yuchi Chen,Fangmei Zhou,Zhishan Ding,Bingqi Zhu
Diabetic wounds impose enormous distress and financial burden on patients, and finding effective dressings to manage wounds is critical. As a Chinese herbal medicine with a long history of Clinical application, Bletilla striata has significant medicinal effects in the therapy of various wounds. In this study, PLA and the pharmacodynamic substances of Bletilla striata were prepared into fibrous scaffolds
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Evaluation and comparison of the efficacy of autologous fibrin glue with 4-0 silk sutures in periodontal flap closure and wound healing - A split mouth randomized controlled trial. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-10 Neha Pradhan,Sphoorthi Anup Belludi,Sreeparvathy R,Veena Hr,Rani James
BACKGROUND Fibrin glue has shown to be a pioneering remedy to overcome the inconvenience of suturing. Autologous products reduce the risk of contamination and immunological responses compared to commercial fibrin glue. Hence using autologous fibrin glue (AFG) as a tissue sealant in periodontal flap closure would be of added value for a predictable outcome. OBJECTIVE To evaluate and compare the efficacy
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Sweroside functionalized with Mesenchymal Stem cells derived exosomes attenuates sepsis-induced myocardial injury by modulating oxidative stress and apoptosis in rats. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-10 Jianghai Wang,Xiaochen Ma,Xuepeng Si,Wang Han
Sepsis is a life-threatening problem by organ dysfunction influenced by negative inflammatory responses and stimulated oxidative stress, which most of sepsis patients about 40-60% are accompanied with myocardial injury. Recently, stem cells derived exosomes could effectively apply in the numerous diseases by combined with natural therapeutic agents. In the present investigation, Sweroside functionalized
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Imaging application of an MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-02 Xinglu Zhou,Changmei Zhang,Qiquan Zhou,Jian Liang,Xiaoyan Zhang,Yujie Shi,Jingna Zhu,Lei Zhong
In recent years, the application of nanoimaging technology on standardize tumor diagnosis has become a new research hotspot, especially nanoprobes. Our research group has synthesized a kind of nanocarrier, mPEG2000-GPLGIAGQ-DSPE, which has the characteristic of matrix metalloproteinase-2 (MMP2) sensitive ability in tumor microenvironment. Meanwhile, the encapsulation method is adopted to prepare MMP2-sensitive
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Exploring the potential of magnesium oxychloride, an amorphous magnesium phosphate, and newberyite as possible bone cement candidates. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-08-01 Friederike Kaiser,Lena Schröter,Philipp Wohlfahrt,Isabel Geroneit,Jérôme Murek,Philipp Stahlhut,Jan Weichhold,Anita Ignatius,Uwe Gbureck
Magnesium phosphate-based bone cements, particularly struvite (MgNH4PO4∙6H2O)-forming cements, have attracted increased scientific interest in recent years because they exhibit similar biocompatibility to hydroxyapatite while degrading much more rapidly in vivo. However, other magnesium-based minerals which might be promising are, to date, little studied. Therefore, in this study, we investigated three
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A scoping review of graphene-based biomaterials for in vivo bone tissue engineering. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-26 Gustavo L Achôa,Patrícia A Mattos,Adam Clements,Yvonne Roca,Zachary Brooks,José Ricardo M Ferreira,Raul Canal,Tiago L Fernandes,Rachel Riera,Mariane T Amano,Akishige Hokugo,Reza Jarrahy,Guilherme Fb Lenz E Silva,Daniela F Bueno
The growing demand for more efficient materials for medical applications brought together two previously distinct fields: medicine and engineering. Regenerative medicine has evolved with the engineering contributions to improve materials and devices for medical use. In this regard, graphene is one of the most promising materials for bone tissue engineering and its potential for bone repair has been
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3D-printed tortuous vessels with Photodissociable and morphology-controllable ink. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-24 Biling Wang,Pengcheng Zhao,Peng Zhang,Jun Hu,Yande Liu,Mingjun Xie,Yong He
Acute ischemic stroke (AIS) is a high mortality cerebrovascular disease associated with vessel curvature. However, the relevant mechanism remains unclear due to a lack of appropriate tortuous vascular models to investigate and validate. This study explores the combination of projection-based 3D bioprinting (PBP) with photo-stimulus-responsive techniques to fabricate a sodium alginate (SA)/acrylamide
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Tideglusib-incorporated nanofibrous scaffolds potently induce odontogenic differentiation. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-24 Nadia Tabassum,Saira Khalid,Sarah Ghafoor,Kyung Mi Woo,Eun Hye Lee,Muhammad Samie,Kiran Konain,Sasikumar Ponnusamy,Praveen Arany,Saeed Ur Rahman
Pulp-Dentin regeneration is a key aspect of maintain tooth vitality and enabling good oral-systemic health. This study aimed to investigate a nanofibrous scaffold loaded with a small molecule i.e. Tideglusib to promote odontogenic differentiation. Tideglusib (GSK-3β inhibitor) interaction with GSK-3β was determined using molecular docking and stabilization of β-catenin was examined by confocal microscopy
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The immune-stealth polymeric coating on drug delivery nanocarriers: In vitro engineering and in vivo fate. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-22 Nadia Shafaei,Sajedeh Khorshidi,Akbar Karkhaneh
Although essential nanosystems such as nanoparticles and nanocarriers are desirable options for transporting various drug molecules into the biological environment, they rapidly remove from the circulatory system due to their interaction with multiple in vivo barriers, especially the immune barrier, which will result in their short-term effects. In order to improve their effectiveness and durability
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An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-21 Safina Abid,Saima Zulfiqar,Muhammad A Anjum,Anthony J Bullock,Sheila MacNeil,Muhammad Yar
Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antibacterial activity would be attractive for diabetic and superficial wound healing. Hydrogels delivered from tubes have several desirable features -they are easy to apply, keep the wound moist, reduce the entry of microorganisms and avoid the need for painful dressing removal. Previously we reported that 2
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In vitro evaluation of blood plasma coagulation responses to four medical-grade polyurethane polymers. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-20 Lan Nguyen,Li-Chong Xu,Eric Yeager,William J Weiss,Christopher A Siedlecki
Segmented polyurethane (PU) block copolymers are widely used in implantable cardiovascular medical devices due to their good biocompatibility and excellent mechanical properties. More specifically, PU Biospan MS/0.4 was used in ventricular assist devices over the past decades. However, this product is being discontinued and it has become necessary to find an alternative PU biomaterial for application
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Physico chemical characterisation of pectin incorporated gelatin sponge and its functional evaluation in modulating contact activation haemostasis. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-15 Remya Ns,Lynda Thomas,Priyanka A,Anugya Bhatt
Even though it is a common occurrence in practice, maintaining haemostasis can sometimes become a challenging issue in case of trauma, perioperative period, coagulation disorders, cancers, etc. Hemostatic materials are extensively used to assist in the cessation of bleeding. However, the definition of efficiency of haemostasis varies between intended procedures. This paper explores the feasibility
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Preparation and in vitro characterization studies of astaxanthin-loaded nanostructured lipid carriers with antioxidant properties. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-15 Liyuan Gu,Wenjuan Wang,Bi Wu,Suping Ji,Qiang Xia
The purpose of this study was to evaluate the astaxanthin-loaded nanostructured lipid carriers (ASX-NLC) prepared using a high-pressure homogenization transport system for local application of astaxanthin. Dynamic light scattering (DLS) and X-ray diffraction (XRD) were used to study the effect of microencapsulation on the properties of ASX-NLC. The mean size of ASX-NLC was about 108.43 ± 0.26 nm and
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Development of Zn/Ce containing bioactive glasses for bone regeneration applications. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-13 Parichart Naruphontjirakul,Nattida Suwanakitti
The impact of either Zn or Ce substituted with Ca in bioactive glasses based on the 45SiO2 - 6P2O5 - 11SrO - (38-(x + y) CaO) - xZnO or yCe2O3 (xZn-yCeBGs) system on bone regeneration has not yet been reported. The aim of this study was to develop new formulations of sol-gel-derived bioactive glass to use as a synthetic bone graft. xZn-yCeBGs were synthesized through the sol-gel process with 0.01 M
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PLCL-TPU bi-layered artificial blood vessel with compliance matching to host vessel. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-07-05 Lihua Guan,Huijing Zhao,Kai Wang,Ke-Qin Zhang,Kai Meng
Compliance mismatch between the artificial blood vessel and the host vessel leads to abnormal hemodynamics and is a major mechanical trigger of intimal hyperplasia. Efforts have been made to achieve higher compliance of artificial blood vessels. However, the preparation of artificial blood vessels with compliance matching to host vessels has not been realized. A bi-layered artificial blood vessel was
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A sustained release lubrication method of agarose-sodium hyaluronate hydrogels for artificial joint. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-06-29 Chunbiao Ruan,Ange Nsilani Kouediatouka,Qi Liu,Guangneng Dong
The artificial joint prosthesis's surface is subjected to wear due to the destruction of the joint lubrication environment after surgery. In this study, an agarose-sodium hyaluronate hydrogel was used as lubricant additive in order to supply and preserve the lubricating fluid of artificial joint prostheses. A ball on disc experiment was conducted using this hydrogel to evaluate the lubrication efficiency
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Galactose-functionalized injectable thermosensitive microgels for target specific uptake in hepatoma cells. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-06-29 Qianru Zhang,Lili Zhu,Tianyi Zhang,Jing Quan
Microgels acts as a potential candidate for responsive composite materials, which has been favored by scientists because of its excellent colloid stability, easy integration, and most of their surface area can be used as support after modification. Specififically, microgels are fascinating capable of maintaining good biocompatibility and controlled-release in vivo and making the possible for applications
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Application of cell laden hydrogels with temporally tunable stiffness in biomedical research. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-06-26 Naghmeh AhmadianKia,Zahra Goli-Malekabadi,Shayan Pournaghmeh
Extracellular matrix (ECM) is a dynamic and complex environment regulating the cell fate and behavior. It is characterized by biophysical and biochemical properties specific for each tissue. Interestingly, hydrogels can serve as exceptional artificial cellular microenvironments as they can be designed to mimic the key features of the native ECM. They are valuable tools to understand how cells respond
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Research and therapeutic applications of silk proteins in cancer. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-06-21 Neema Kumari,Narasimha Pullaguri,Vikas Sahu,Kranti Kiran Reddy Ealla
Despite the availability of advanced treatments, cancer remains the second leading cause of death worldwide. This is due to the many challenges prevailing in the research field and cancer therapy. Resistance to therapy and side effects provide major hindrances to recovery from cancer. As a result, in addition to the aim of killing cancer cells, the focus should also be on reducing or preventing side
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Stromal vascular fraction gel promoted wound healing and peripheral nerve repair in diabetic rats via TLRs/MyD88/NF-κB signaling pathway. J. Biomater. Appl. (IF 2.9) Pub Date : 2023-06-21 Nan Xing,Jincun Yang,Haitao Wang,Lei Peng,Xiaowen Liu,Jiong Chen,Yan Liu
Diabetes mellitus (DM) contributes to impaired wound healing. This study was aimed to evaluate the effect of stromal vascular fraction (SVF) gel extracted from rats on diabetic ulcers wound healing and peripheral nerve repair. 60 Sprague Dawley (SD) rats were divided into 6 groups, including control, model, SVF-gel low dose (SVF-gel-L), SVF-gel high dose (SVF-gel-H), ST2825, and SVF-gel-H + CL075 groups