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State of knowledge on ammonia handling by the kidney Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-03-07 Soline Bourgeois, Pascal Houillier
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New functions and roles of the Na+-H+-exchanger NHE3 Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-03-07
Abstract The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it contributes to hydrogen secretion and sodium (re)absorption. The roles of this transporter have been studied by the use of the respective knockout mice and by using pharmacological inhibitors. Whole-body NHE3 knockout mice suffer from a high mortality rate (with only ∼30% of mice surviving into
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Locally applied heat stress during exercise training may promote adaptations to mitochondrial enzyme activities in skeletal muscle Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-03-06 Ed Maunder, Andrew King, Jeffrey A. Rothschild, Matthew J. Brick, Warren B. Leigh, Christopher P. Hedges, Troy L. Merry, Andrew E. Kilding
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Establishment of the deuterium oxide dilution method as a new possibility for determining the transendothelial water permeability Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-03-05
Abstract Increase in transendothelial water permeability is an essential etiological factor in a variety of diseases like edema and shock. Despite the high clinical relevance, there has been no precise method to detect transendothelial water flow until now. The deuterium oxide (D2O) dilution method, already established for measuring transepithelial water transport, was used to precisely determine the
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Heat production during exercise in pregnancy: discerning the contribution of total body weight Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-03-04
Abstract Studies have reported enhanced thermoregulatory function as pregnancy progresses; however, it is unclear if differences in thermoregulation are attributed to weight gain or other physiological changes. This study aimed to determine if total body weight will influence thermoregulation (heat production (Hprod)), heart rate, and perceptual measurements in response to weight-bearing exercise during
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Biophysical mechanisms of myocardium sodium channelopathies Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-03-01 Anastasia K. Zaytseva, Olga E. Kulichik, Anna. A. Kostareva, Boris S. Zhorov
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PTHrP attenuates spontaneous contractions in detrusor smooth muscle of the rat bladder by activating spontaneous transient outward potassium currents Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-29 Wataru Kudo, Hikaru Hashitani
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Application of near infra-red laser light increases current threshold in optic nerve consistent with increased Na+-dependent transport Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-29 Hin Heng Lo, Tawan Munkongcharoen, Rosa M. Muijen, Ritika Gurung, Anjali G. Umredkar, Mark D. Baker
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Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-28 Dingding Lv, Bin Xiao, Huaying Liu, Linping Wang, Yingshun Li, Yin Hua Zhang, Qinghua Jin
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Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-24 Tuulia Ala-Nisula, Riikka Halmetoja, Henri Leinonen, Margareta Kurkela, Henna-Riikka Lipponen, Samuli Sakko, Mikko Karpale, Antti M. Salo, Niina Sissala, Tapio Röning, Ghulam S. Raza, Kari A. Mäkelä, Jérôme Thevenot, Karl-Heinz Herzig, Raisa Serpi, Johanna Myllyharju, Heikki Tanila, Peppi Koivunen, Elitsa Y. Dimova
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Only bioactive forms of PTH (n-oxPTH and Met18(ox)-PTH) inhibit synthesis of sclerostin – evidence from in vitro and human studies Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-23 Mei Li, Ahmed A. Hasan, Chang Chu, Johann-Georg Hocher, Yvonne Liu, Xiaoli Zhang, Xin Chen, Benito Yard, Bernhard K. Krämer, Berthold Hocher
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Strengthening the basics: acids and bases influence vascular structure and function, tissue perfusion, blood pressure, and human cardiovascular disease Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-22 Ebbe Boedtkjer, Tarannum Ara
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Cerebrospinal fluid pH regulation Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-22
Abstract The cerebrospinal fluid (CSF) fills the brain ventricles and the subarachnoid space surrounding the brain and spinal cord. The fluid compartment of the brain ventricles communicates with the interstitial fluid of the brain across the ependyma. In comparison to blood, the CSF contains very little protein to buffer acid–base challenges. Nevertheless, the CSF responds efficiently to changes in
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A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-22 Catharina J. Küng, Arezoo Daryadel, Rocio Fuente, Betül Haykir, Martin Hrabĕ de Angelis, Nati Hernando, Isabel Rubio-Aliaga, Carsten A. Wagner
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Electronic cigarettes and cardiovascular disease: epidemiological and biological links Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-20 Huiqi Zong, Zhekai Hu, Weina Li, Mina Wang, Qi Zhou, Xiang Li, Hongxu Liu
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Multimodal cortical neuronal cell type classification Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-20 Xiaoyi Mao, Jochen F. Staiger
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Bicarbonate secretion and acid/base sensing by the intestine Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-19 Holger M. Becker, Ursula E. Seidler
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Evaluation of skeletal muscle function in male rats with doxorubicin-induced myopathy following various exercise techniques: the significant role of glucose transporter 4 Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-17
Abstract A common anthracycline antibiotic used to treat cancer patients is doxorubicin (DOX). One of the effects of DOX therapy is skeletal muscle fatigue. Our goal in this research was to study the beneficial effect of exercise on DOX-induced damaged muscle fibers and compare the effect of different exercise strategies (prophylactic, post- toxicity and combined) on DOX toxicity. Five groups were
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Intertwined regulators: hypoxia pathway proteins, microRNAs, and phosphodiesterases in the control of steroidogenesis Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-15 Stephen Ariyeloye, Susanne Kämmerer, Erik Klapproth, Ben Wielockx, Ali El-Armouche
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Recent advances in acid sensing by G protein coupled receptors Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-10 Maike D. Glitsch
Changes in extracellular proton concentrations occur in a variety of tissues over a range of timescales under physiological conditions and also accompany virtually all pathologies, notably cancers, stroke, inflammation and trauma. Proton-activated, G protein coupled receptors are already partially active at physiological extracellular proton concentrations and their activity increases with rising proton
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Acid–base transporters in the context of tumor heterogeneity Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-09
Abstract The copious metabolic acid production and -extrusion by cancer cells render poorly vascularized regions of solid tumors highly acidic. A growing list of proton - and bicarbonate transporters has been suggested to contribute to net acid extrusion from cancer cells, and/or been shown to be dysregulated and favor malignant development in various cancers. The great majority of these roles have
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Effects of physical training on hypothalamic neuronal activation and expressions of vasopressin and oxytocin in SHR after running until fatigue Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-03
Abstract To assess the influence of physical training on neuronal activation and hypothalamic expression of vasopressin and oxytocin in spontaneously hypertensive rats (SHR), untrained and trained normotensive rats and SHR were submitted to running until fatigue while internal body and tail temperatures were recorded. Hypothalamic c-Fos expression was evaluated in thermoregulatory centers such as the
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Renal and cardiac effects of the PDE9 inhibitor BAY 73–6691 in 5/6 nephrectomized rats Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-02-02 Xin Chen, Denis Delić, Yaochen Cao, Zeyu Zhang, Hongwei Wu, Ahmed A. Hasan, Mohamed M. S. Gaballa, Lianghong Yin, Bernhard K. Krämer, Thomas Klein, Xin Shi, Ben He, Linghong Shen, Berthold Hocher
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Cargo-specific effects of hypoxia on clathrin-mediated trafficking Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-31 Gijsbert J. van Belle, Anke Zieseniss, Doris Heidenreich, Maxime Olmos, Asia Zhuikova, Wiebke Möbius, Maarten W. Paul, Dörthe M. Katschinski
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Dietary acid load in health and disease Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-29
Abstract Maintaining an appropriate acid–base equilibrium is crucial for human health. A primary influencer of this equilibrium is diet, as foods are metabolized into non-volatile acids or bases. Dietary acid load (DAL) is a measure of the acid load derived from diet, taking into account both the potential renal acid load (PRAL) from food components like protein, potassium, phosphorus, calcium, and
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Metabolic acidosis in chronic kidney disease: mere consequence or also culprit? Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-27 Christian Kuhn, Nilufar Mohebbi, Alexander Ritter
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Histamine H2-receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II–hypertensive mice Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-27 Kasper B. Assersen, Boye L. Jensen, Camilla Enggaard, Paul M. Vanhoutte, Pernille B. L. Hansen
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The mechanism of 25-hydroxycholesterol-mediated suppression of atrial β1-adrenergic responses Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-22
Abstract 25-Hydroxycholesterol (25HC) is a biologically active oxysterol, whose production greatly increases during inflammation by macrophages and dendritic cells. The inflammatory reactions are frequently accompanied by changes in heart regulation, such as blunting of the cardiac β-adrenergic receptor (AR) signaling. Here, the mechanism of 25HC-dependent modulation of responses to β-AR activation
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The renin angiotensin aldosterone system Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-17 Hannah Triebel, Hayo Castrop
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Role of corticotropin-releasing factor neurotransmission in the lateral hypothalamus on baroreflex impairment evoked by chronic variable stress in rats Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-17 Lucas Barretto-de-Souza, Ricardo Benini, Lilian L. Reis-Silva, Cristiane Busnardo, Carlos C. Crestani
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Intercalated cell function, kidney innate immunity, and urinary tract infections Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-16 Andrew L. Schwaderer, Evan Rajadhyaksha, Jorge Canas, Vijay Saxena, David S. Hains
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Secretin: a hormone for HCO3− homeostasis Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-15 Peder Berg, Samuel L. Svendsen, Niklas Ayasse, Mads Vaarby Sorensen, Jens Leipziger
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pH-regulated single cell migration Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-12 Christian Stock
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The good company of T-type calcium channels Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-09 Philippe Lory
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Novel functions of the anion exchanger AE4 (SLC4A9) Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-09 Helga Vitzthum, Catherine Meyer-Schwesinger, Heimo Ehmke
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Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link? Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-04 Stefan Gründer, Jakob Vanek, Karolos-Philippos Pissas
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Artificial light at night suppresses the day-night cardiovascular variability: evidence from humans and rats Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2024-01-04
Abstract Artificial light at night (ALAN) affects most of the population. Through the retinohypothalamic tract, ALAN modulates the activity of the central circadian oscillator and, consequently, various physiological systems, including the cardiovascular one. We summarised the current knowledge about the effects of ALAN on the cardiovascular system in diurnal and nocturnal animals. Based on published
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The role of HCN channels on the effects of T-type calcium channels and GABAA receptors in the absence epilepsy model of WAG/Rij rats Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-30 Emre Soner Tiryaki, Gökhan Arslan, Caner Günaydın, Mustafa Ayyıldız, Erdal Ağar
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How kidney function adapts to changes in acid–base balance: the AE4 transporter as a central acid–base sensor in tubular cells Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-20 Frank Schweda
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Pendrin: linking acid base to blood pressure Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-19
Abstract Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which is mutated in human patients affected by Pendred syndrome, an autosomal recessive disease characterized by sensoneurinal deafness and hypothyroidism. Pendrin is also expressed in the kidney where it mediates the exchange of internal HCO3− for external Cl− at the apical surface of renal type B and non-A non-B-intercalated
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Pain quality patterns in delayed onset muscle soreness of the lower back suggest sensitization of fascia rather than muscle afferents: a secondary analysis study Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-16 Andreas Brandl, Jan Wilke, Christoph Egner, Tobias Schmidt, Andreas Schilder, Robert Schleip
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Cardiac optogenetics: shining light on signaling pathways Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-14 Siri Leemann, Franziska Schneider-Warme, Sonja Kleinlogel
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In silico optical modulation of spiral wave trajectories in cardiac tissue Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-14 Sayedeh Hussaini, Rupamanjari Majumder, Valentin Krinski, Stefan Luther
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Lectin-mediated, time-efficient, and high-yield sorting of different morphologically intact nephron segments Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-13 Jessica Roskosch, Uyen Huynh-Do, Stefan Rudloff
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State-independent inhibition of the oncogenic Kv10.1 channel by desethylamiodarone, a comparison with amiodarone Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-08 F. Gomez-Lagunas, C. Barriga-Montoya, J. P. Pardo
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Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-04 Sinenhlanhla X. H. Mthembu, Sithandiwe E. Mazibuko-Mbeje, Khanyisani Ziqubu, Ndivhuwo Muvhulawa, Fabio Marcheggiani, Ilenia Cirilli, Bongani B. Nkambule, Christo J. F. Muller, Albertus K. Basson, Luca Tiano, Phiwayinkosi V. Dludla
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Optogenetics meets physiology Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-04 Sophia Ohnemus, Johannes Vierock, Franziska Schneider-Warme
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Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-01 Jessica Rodgers, Phillip Wright, Edward R. Ballister, Rebecca B. Hughes, Riccardo Storchi, Jonathan Wynne, Franck P. Martial, Robert J. Lucas
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GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-01 Francesca Semino, Fabrice F. Darche, Claus Bruehl, Michael Koenen, Heyko Skladny, Hugo A. Katus, Norbert Frey, Andreas Draguhn, Patrick A. Schweizer
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The T-type calcium channelosome Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-12-01 Norbert Weiss, Gerald W. Zamponi
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Ethics and regulation of neuronal optogenetics in the European Union Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-24 Timo Faltus, Johannes Freise, Carsten Fluck, Hans Zillmann
Neuronal optogenetics is a technique to control the activity of neurons with light. This is achieved by artificial expression of light-sensitive ion channels in the target cells. By optogenetic methods, cells that are naturally light-insensitive can be made photosensitive and addressable by illumination and precisely controllable in time and space. So far, optogenetics has primarily been a basic research
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Age-dependent effects of the β3 adrenoceptor agonist CL316,243 on human and rat detrusor muscle strips Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-22 Charlotte Petereit, Katrin Porath, Simone Rackow, Karoline Kernig, Oliver W. Hakenberg, Rüdiger Köhling, Timo Kirschstein
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Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-23 Guangbo Zhang, Guochun Yang, Yanzhao Zhou, Zhengtao Cao, Ming Yin, Lin Ma, Ming Fan, Yong-Qi Zhao, Lingling Zhu
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What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes? Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-24 Bobby White, Pawel Swietach
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Enzymatic vitamin A2 production enables red-shifted optogenetics Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-21 Johanna Gerhards, Leo I. Volkov, Joseph C. Corbo, Daniela Malan, Philipp Sasse
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The sensitivity of mechanoelectrical transduction response phase to acoustic overstimulation is calcium-dependent Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-21 Pierre Hakizimana
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Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-22 Katalin Eszter Ibos, Éva Bodnár, Hoa Dinh, Merse Kis, Fanni Márványkövi, Zsuzsanna Z. A. Kovács, Andrea Siska, Imre Földesi, Zsolt Galla, Péter Monostori, István Szatmári, Péter Simon, Márta Sárközy, Krisztina Csabafi
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Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-18 Jiraporn Ousingsawat, Raquel Centeio, Rainer Schreiber, Karl Kunzelmann
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Amyloid plaques and normal ageing have differential effects on microglial Ca2+ activity in the mouse brain Pflugers Arch. Eur. J. Physiol. (IF 4.5) Pub Date : 2023-11-15 Pablo Izquierdo, Renaud B. Jolivet, David Attwell, Christian Madry