-
Lineage‐specific requirements of Alx4 function in craniofacial and hair development Dev. Dyn. (IF 2.5) Pub Date : 2024-03-14 Yu Lan, Zhaoming Wu, Han Liu, Rulang Jiang
BackgroundDisruption of ALX4 causes autosomal dominant parietal foramina and autosomal recessive frontonasal dysplasia with alopecia, but the mechanisms involving ALX4 in craniofacial and other developmental processes are not well understood. Although mice carrying distinct mutations in Alx4 have been previously reported, the perinatal lethality of homozygous mutants together with dynamic patterns
-
Analysis of changes in the action potential morphology of the mouse sinoatrial node true pacemaker cells during ontogenetic development in vitro and in silico Dev. Dyn. (IF 2.5) Pub Date : 2024-03-09 Alexander Ryvkin, Arseniy Furman, Elena Lebedeva, Mikhail Gonotkov
BackgroundMaturation of the mouse is accompanied by the increase in heart rate. However, the mechanisms underlying this process remain unclear. We performed an action potentials (APs) recordings in mouse sinoatrial node (SAN) true pacemaker cells and in silico analysis to clarify the mechanisms underlying pre–postnatal period heart rate changes.ResultsThe APs of true pacemaker cells at different stages
-
Establishment of a Diamond‐Blackfan anemia like model in zebrafish Dev. Dyn. (IF 2.5) Pub Date : 2024-03-07 Yiming Ling, Jiaye Wu, Yushi Liu, Panpan Meng, Ying Sun, Dejian Zhao, Qing Lin
BackgroundAnemia is defined as a lack of erythrocytes, low hemoglobin levels, or abnormal erythrocyte morphology. Diamond‐Blackfan anemia (DBA) is a rare and severe congenital hypoplastic anemia that occurs due to the dominant inheritance of a ribosomal protein gene mutation. Even rarer is a case described as Diamond‐Blackfan anemia like (DBAL), which occurs due to a loss‐of‐function EPO mutation recessive
-
-
Cover Image Dev. Dyn. (IF 2.5) Pub Date : 2024-03-01 Steven R. Byrum, Bryan S. Frazier, R. Dean Grubbs, Gavin J. P. Naylor, Gareth J. Fraser
-
Editorial highlights Dev. Dyn. (IF 2.5) Pub Date : 2024-03-01 Paul A. Trainor
Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in Developmental Dynamics that illustrate the complex dynamics
-
Requirement of a novel gene, drish, in the zebrafish retinal ganglion cell and primary motor axon development Dev. Dyn. (IF 2.5) Pub Date : 2024-02-10 Suman Gurung, Nicole K. Restrepo, Surendra Kumar Anand, Vinoth Sittaramane, Saulius Sumanas
During neurogenesis, growing axons must navigate through the complex extracellular environment and make correct synaptic connections for the proper functioning of neural circuits. The mechanisms underlying the formation of functional neural networks are still only partially understood.
-
Cold storage and cryopreservation methods for spermatozoa of the sea urchins Lytechinus pictus and Strongylocentrotus purpuratus Dev. Dyn. (IF 2.5) Pub Date : 2024-02-10 Victor D. Vacquier, Amro Hamdoun
Sea urchins have contributed greatly to knowledge of fertilization, embryogenesis, and cell biology. However, until now, they have not been genetic model organisms because of their long generation times and lack of tools for husbandry and gene manipulation. We recently established the sea urchin Lytechinus pictus, as a multigenerational model Echinoderm, because of its relatively short generation time
-
The dwarf neon rainbowfish Melanotaenia praecox, a small spiny-rayed fish with potential as a new Acanthomorpha model fish: I. Fin ray ontogeny and postembryonic Dev. Dyn. (IF 2.5) Pub Date : 2024-02-07 Kazuhide Miyamoto, Gembu Abe, Koji Tamura
Fish fins with highly variable color patterns and morphologies have many functions. In Actinopterygii, the free parts of fins are supported by “soft rays” and “spiny rays.” Spiny rays have various functions and are extremely modified in some species, but they are lacking in popular model fish such as zebrafish and medaka. Additionally, some model fish with spiny rays are difficult to maintain in ordinary
-
The dwarf neon rainbowfish Melanotaenia praecox, a small spiny-rayed fish with potential as a new Acanthomorpha model fish: II. Establishment of a microinjection procedure for genetic engineering Dev. Dyn. (IF 2.5) Pub Date : 2024-02-05 Kazuhide Miyamoto, Gembu Abe, Koichi Kawakami, Koji Tamura, Satoshi Ansai
Rainbowfish is a clade of colorful freshwater fish. Melanotaenia praecox is a small rainbowfish species with biological characteristics that make it potentially useful as an experimental model species. We anticipate that M. praecox could become a new model used in various fields, such as ecology, evolution, and developmental biology. However, few previous studies have described experimental set-ups
-
The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration Dev. Dyn. (IF 2.5) Pub Date : 2024-01-30 Alejandro Castilla-Ibeas, Sofía Zdral, Kerby C. Oberg, Marian A. Ros
The limb anatomy displays well-defined dorsal and ventral compartments, housing extensor, and flexor muscles, which play a crucial role in facilitating limb locomotion and manipulation. Despite its importance, the study of limb dorsoventral patterning has been relatively neglected compared to the other two axes leaving many crucial questions about the genes and developmental processes implicated unanswered
-
Cover Image Dev. Dyn. (IF 2.5) Pub Date : 2024-02-01 Kevin M. Serra, Christina Vyzas, Sarah Shehreen, Iris Chipendo, Katherine M. Clifford, Daniel W. Youngstrom, Stephen H. Devoto
-
Special Editorial: Thank you and Farewell to Dr. Gary C. Schoenwolf Dev. Dyn. (IF 2.5) Pub Date : 2024-02-01 Paul A. Trainor
Many people become very good scientists, and make major contributions to our understanding of biology, or are excellent teachers that have a profound influence on educating generations of scientists. But rare is the individual who excels in both research and education disciplines. Dr Gary Schoenwolf is that rare individual and this month we say farewell and thank you to Dr Schoenwolf after a distinguished
-
Editorial highlights Dev. Dyn. (IF 2.5) Pub Date : 2024-02-01 Paul A. Trainor
Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in Developmental Dynamics that illustrate the complex dynamics
-
Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos Dev. Dyn. (IF 2.5) Pub Date : 2024-01-25 Sung Jun Park, Martin R. Silic, Peyton L. Staab, Jiapei Chen, Ethan L. Zackschewski, GuangJun Zhang
The two-pore domain potassium (K2P) channels are a major type of potassium channels that maintain the cell membrane potential by conducting passive potassium leak currents independent of voltage change. They play prominent roles in multiple physiological processes, including neuromodulation, perception of pain, breathing and mood control, and response to volatile anesthetics. Mutations in K2P channels
-
Localization of cadherins in the postnatal cochlear epithelium and their relation to space formation Dev. Dyn. (IF 2.5) Pub Date : 2024-01-24 Holly J. Beaulac, Vidhya Munnamalai
The sensory epithelium of the cochlea, the organ of Corti, has complex cytoarchitecture consisting of mechanosensory hair cells intercalated by epithelial support cells. The support cells provide important trophic and structural support to the hair cells. Thus, the support cells must be stiff yet compliant enough to withstand and modulate vibrations to the hair cells. Once the sensory cells are properly
-
19th International Xenopus Conference Meeting Report: Latest developments and future perspectives Dev. Dyn. (IF 2.5) Pub Date : 2024-01-23 Coral Zhou, Saurabh Kulkarni
The African clawed frog, Xenopus laevis, and the Western clawed frog, Xenopus tropicalis, have been foundational model organisms for establishing key principles of embryonic development. Today, the utility of Xenopus has been greatly expanded for studying a wide range of biological processes both in health and disease. Here, we describe the latest advancements from the Xenopus community, which span
-
Trim46 knockout impaired neuronal architecture and caused hypoactive behavior in rats Dev. Dyn. (IF 2.5) Pub Date : 2024-01-09 Feifei Guan, Shan Gao, Hanxuan Sheng, Yuanwu Ma, Wei Chen, Xiaolong Qi, Xu Zhang, Xiang Gao, Shuo Pang, Lianfeng Zhang, Li Zhang
Tripartite motif (TRIM46) is a relatively novel protein that belongs to tripartite motif family. TRIM46 organizes parallel microtubule arrays on the axons, which are important for neuronal polarity and axonal function. TRIM46 is highly expressed in the brain, but its biological function in adults has not yet been determined.
-
Evolving topological order in the postnatal visceral pleura Dev. Dyn. (IF 2.5) Pub Date : 2024-01-03 Betty S. Liu, Ali B. Ali, Stacey P. Kwan, Jennifer M. Pan, Willi L. Wagner, Hassan A. Khalil, Zi Chen, Maximilian Ackermann, Steven J. Mentzer
Changes in epithelial cell shape reflects optimal cell packing and the minimization of surface free energy, but also cell–cell interactions, cell proliferation, and cytoskeletal rearrangements.
-
-
From pumps to pipes: A special issue on mechanisms of cardiovascular development Dev. Dyn. (IF 2.5) Pub Date : 2024-01-02 Mathilda Mommersteeg, Benjamin M. Hogan
In this special issue on “Mechanisms of cardiovascular development,” we present a series of studies that explore key questions in cardiovascular developmental biology and regeneration. In recent decades, the broad field of cardiovascular development has expanded to encompass new areas of investigation such as organ specific vascular networks, regeneration of the heart and vessels, as well as the role
-
Embryonic development of the neotropical pit viper Bothrops atrox (Serpentes: Viperidae: Crotalinae), with emphasis on pit organ morphogenesis and its evolution in snakes Dev. Dyn. (IF 2.5) Pub Date : 2023-12-29 Fernanda Magalhães Silva, Ricardo Arturo Guerra-Fuentes, David C. Blackburn, Ana L. Costa Prudente
Bothrops atrox is a pit viper with a loreal pit organ, and its embryological development remains undescribed. Here, we provide a comprehensive description of the embryology of B. atrox, focusing on the loreal pit organ and cephalic scales.
-
Grb7 knockout mice develop normally but litters born to knockout females fail to thrive Dev. Dyn. (IF 2.5) Pub Date : 2023-12-23 Kristopher A. Lofgren, Paraic A. Kenny
Growth factor receptor-bound 7 (Grb7) is an adaptor protein involved in signal transduction downstream of multiple receptor tyrosine kinases, including ERBB, FGFR, and PDGFR pathways. Experimental studies have implicated Grb7 in regulating cell proliferation, survival, migration, and invasion through its large repertoire of protein–protein interactions.
-
Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development Dev. Dyn. (IF 2.5) Pub Date : 2023-12-22 Yanhui Lin, Weibo Tang, Peijun Huang, Zhendong Wang, Lian Duan, Chonghui Jia, Ruizhen Sun, Li Liu, Jingling Shen
A precise balance between the proliferation and differentiation of epidermal progenitors is required to achieve the barrier function during the development of epidermis. During the entire process of skin development, the newly formed basal layer cells divide, differentiate, and migrate outward to the surface of the skin, which is tightly regulated by a series of events related to cell cycle progression
-
Tetrahedral serial multiview microscopy and image fusion for improved resolution and extent in stained zebrafish embryos Dev. Dyn. (IF 2.5) Pub Date : 2023-12-22 Johanna B. Kroll, Anna Cha, Alon Oyler-Yaniv, Talley Lambert, Ian A. Swinburne, Andrew Murphy, Sean G. Megason
Spatial mapping on the single-cell level over the whole organism can uncover roles of molecular players involved in vertebrate development. Custom microscopes have been developed that use multiple objectives to view a sample from multiple views at the same time. Such multiview imaging approaches can improve resolution and uniformity of image quality as well as allow whole embryos to be imaged (Swoger
-
Computational simulation of JAK/STAT signaling in somatic versus germline stem cells Dev. Dyn. (IF 2.5) Pub Date : 2023-12-21 Willis X. Li
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway regulates a variety of cellular processes. A major activation event in this pathway involves the phosphorylation of a tyrosine of STAT, converting unphosphorylated STAT (uSTAT) to phosphorylated STAT (pSTAT), an active transcription factor. In a noncanonical role, uSTAT contributes to the maintenance of heterochromatin
-
Identification of distinct vascular mural cell populations during zebrafish embryonic development Dev. Dyn. (IF 2.5) Pub Date : 2023-12-19 Sarah Colijn, Miku Nambara, Gracie Malin, Elena A. Sacchetti, Amber N. Stratman
Mural cells are an essential perivascular cell population that associate with blood vessels and contribute to vascular stabilization and tone. In the embryonic zebrafish vasculature, pdgfrb and tagln are commonly used as markers for identifying pericytes and vascular smooth muscle cells. However, the overlapping and distinct expression patterns of these markers in tandem have not been fully described
-
Nonmuscular Troponin-I is required for gastrulation in sea urchin embryos Dev. Dyn. (IF 2.5) Pub Date : 2023-12-10 Mai Kamata, Yuri Taniguchi, Junko Yaguchi, Hiroyuki Tanaka, Shunsuke Yaguchi
Gastrulation is one of the most important events in our lives (Barresi and Gilbert, 2020, Developmental Biology, 12th ed.). The molecular mechanisms of gastrulation in multicellular organisms are not yet fully understood, since many molecular, physical, and chemical factors are involved in the event.
-
Elevated Id2 expression causes defective meiosis and spermatogenesis in mice Dev. Dyn. (IF 2.5) Pub Date : 2023-12-08 Zhen He, Rong-Ge Yan, Qin-Bang Shang, Qi-En Yang
Inhibitors of DNA binding (ID) proteins mainly inhibit gene expression and regulate cell fate decisions by interacting with E-proteins. All four ID proteins (ID1–4) are present in the testis, and ID4 has a particularly important role in spermatogonial stem cell fate determination. Several lines of evidence indicate that ID proteins are involved in meiosis; however, functional experiments have not been
-
Cover Image Dev. Dyn. (IF 2.5) Pub Date : 2023-12-01 Harinarayana Ankamreddy, Ankita Thawani, Onur Birol, Hongyuan Zhang, Andrew K. Groves
-
Editorial highlights Dev. Dyn. (IF 2.5) Pub Date : 2023-12-01 Paul A. Trainor
Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in Developmental Dynamics that illustrate the complex dynamics
-
Exploring the role of mechanical forces on tendon development using in vivo model: A scoping review Dev. Dyn. (IF 2.5) Pub Date : 2023-11-10 Yuna Usami, Hirotaka Iijima, Takanori Kokubun
Tendons transmit the muscle contraction forces to bones and drive joint movement throughout life. While extensive research have indicated the essentiality of mechanical forces on tendon development, a comprehensive understanding of the fundamental role of mechanical forces still needs to be impaerted. This scoping review aimed to summarize the current knowledge about the role of mechanical forces during
-
Kdm7a expression is spatiotemporally regulated in developing Xenopus laevis embryos, and its overexpression influences late retinal development Dev. Dyn. (IF 2.5) Pub Date : 2023-11-01 Davide Martini, Matteo Digregorio, Ilaria Anna Pia Voto, Giuseppe Morabito, Andrea Degl'Innocenti, Guido Giudetti, Martina Giannaccini, Massimiliano Andreazzoli
Post-translational histone modifications are among the most common epigenetic modifications that orchestrate gene expression, playing a pivotal role during embryonic development and in various pathological conditions. Among histone lysine demethylases, KDM7A, also known as KIAA1718 or JHDM1D, catalyzes the demethylation of H3K9me1/2 and H3K27me1/2, leading to transcriptional regulation. Previous data
-
Cover Image Dev. Dyn. (IF 2.5) Pub Date : 2023-11-01 Jason K. B. Nguyen, Patsy Gómez-Picos, Yiwen Liu, Katie Ovens, B. Frank Eames
-
Editorial highlights Dev. Dyn. (IF 2.5) Pub Date : 2023-11-01 Paul A. Trainor
Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in Developmental Dynamics that illustrate the complex dynamics
-
wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis Dev. Dyn. (IF 2.5) Pub Date : 2023-10-23 Erica L. Benard, Ismail Küçükaylak, Julia Hatzold, Kilian U. W. Berendes, Thomas J. Carney, Filippo Beleggia, Matthias Hammerschmidt
Mutations of human WNT10A are associated with odonto-ectodermal dysplasia syndromes. Here, we present analyses of wnt10a loss-of-function mutants in the zebrafish.
-
Is African non-annual killifish Fundulopanchax gardneri (Teleostei; Cyprinodontiformes; Nothobranchiidae) true non-annual? Dev. Dyn. (IF 2.5) Pub Date : 2023-10-19 Vasily Borisov, Fedor Shkil, Dmitry Seleznev, Sergei Smirnov
Annual or seasonal killifishes (Cyprinodontiformes: Nothobranchiidae) are unique among fish in their ability to enter into developmental arrests (diapauses: DI, DII, and DIII). They have a short lifespan and their embryos are exceptionally tolerant to a variety of environmental stresses. These traits make them a popular model for studying vertebrate diapause, aging, stress tolerance, genome adaptation
-
Specific CaMKIIs mediate convergent extension cell movements in early zebrafish development Dev. Dyn. (IF 2.5) Pub Date : 2023-10-20 Jamie J. McLeod, Sarah C. Rothschild, Ludmila Francescatto, Haerin Kim, Robert M. Tombes
Noncanonical Wnts are morphogens that can elevate intracellular Ca2+, activate the Ca2+/calmodulin-dependent protein kinase, CaMKII, and promote cell movements during vertebrate gastrulation.
-
Maternal exposure to hyperbaric oxygen at the preimplantation stages increases apoptosis and ectopic Cdx2 expression and decreases Oct4 expression in mouse blastocysts via Nrf2-Notch1 upregulation and Nf2 downregulation Dev. Dyn. (IF 2.5) Pub Date : 2023-10-18 Yu-Ming Li, Yu Lang Chung, Yung-Fu Wu, Chien-Kuo Wang, Chieh-Min Chen, Yi-Hui Chen
The environmental oxygen tension has been reported to impact the blastocyst quality and cell numbers in the inner cell mass (ICM) during human and murine embryogenesis. While the molecular mechanisms leading to increased ICM cell numbers and pluripotency gene expression under hypoxia have been deciphered, it remains unknown which regulatory pathways caused the underweight fetal body and overweight
-
Impaired breakdown of Herwig's epithelial root sheath disturbs tooth root development Dev. Dyn. (IF 2.5) Pub Date : 2023-10-18 Ju-Kyung Jeong, Tak-Heun Kim, Hwajung Choi, Eui-Sic Cho
Wnt/β-catenin signaling plays a variety of roles in both the dental epithelium and mesenchyme at most stages of tooth development. In this study, we verified the roles of Hertwig's epithelial root sheath (HERS) breakdown in tooth root development. This breakdown results in formation of epithelial cell rests of Malassez (ERM).
-
Elongation of the developing spinal cord is driven by Oct4-type transcription factor-mediated regulation of retinoic acid signaling in zebrafish embryos Dev. Dyn. (IF 2.5) Pub Date : 2023-10-18 Tatsuya Yuikawa, Takehisa Sato, Masaaki Ikeda, Momo Tsuruoka, Kaede Yasuda, Yuto Sato, Kouhei Nasu, Kyo Yamasu
Elongation of the spinal cord is dependent on neural development from neuromesodermal progenitors in the tail bud. We previously showed the involvement of the Oct4-type gene, pou5f3, in this process in zebrafish mainly by dominant-interference gene induction, but, to compensate for the limitation of this transgene approach, mutant analysis was indispensable. pou5f3 involvement in the signaling pathways
-
Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents Dev. Dyn. (IF 2.5) Pub Date : 2023-10-17 T. A. Mitchell, J. M. Lin, S. M. Hicks, J. R. James, P. Rangan, P. E. Forni
Male-specific lethal 3 (Msl3) is a member of the chromatin-associated male-specific lethal MSL complex, which is responsible for the transcriptional upregulation of genes on the X chromosome in males of Drosophila. Although the dosage complex operates differently in mammals, the Msl3 gene is conserved from flies to humans. Msl3 is required for meiotic entry during Drosophila oogenesis. Recent reports
-
Darwin, Haeckel, and the “Mikluskan gas organ theory” Dev. Dyn. (IF 2.5) Pub Date : 2023-10-14 Ingmar Werneburg, Uwe Hoßfeld, Georgy S. Levit
A previously unknown reference to the Russian ethnologist, biologist, and traveler Nikolai N. Miklucho-Maclay (1846–1888) was discovered in correspondence between Charles Darwin (1809–1882) and Ernst Haeckel (1834–1919). This reference has remained unknown to science, even to Miklucho-Maclay's biographers, probably because Darwin used the Russian nickname “Mikluska” when alluding to this young scientist
-
Cover Image Dev. Dyn. (IF 2.5) Pub Date : 2023-10-03 Rebecca McLennan, Rasa Giniunaite, Katie Hildebrand, Jessica M. Teddy, Jennifer C. Kasemeier-Kulesa, Lizbeth Bolanos, Ruth E. Baker, Philip K. Maini, Paul M. Kulesa
-
Editorial highlights Dev. Dyn. (IF 2.5) Pub Date : 2023-10-03 Paul A. Trainor
Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in Developmental Dynamics that illustrate the complex dynamics
-
Direct diffusion of anti-Müllerian hormone from both the cranial and caudal regions of the testis during early gonadal development in mice Dev. Dyn. (IF 2.5) Pub Date : 2023-10-03 Shiori Kato, Toshifumi Yokoyama, Nobusuke Okunishi, Hiroto Narita, Taisei Fujikawa, Yusuke Kirizuki, Youhei Mantani, Takanori Miki, Nobuhiko Hoshi
The Müllerian duct (MD), the primordium of the female reproductive tract, is also formed in males during the early stage of development, then regresses due to the anti-Müllerian hormone (AMH) secreted from the testes. However, the detailed diffusion pathway of AMH remains unclear. We herein investigated the mechanism by which AMH reaches the middle region of the MD using an organ culture system.
-
Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos Dev. Dyn. (IF 2.5) Pub Date : 2023-09-28 Takuma Shinozuka, Motoko Aoki, Yudai Hatakeyama, Noriaki Sasai, Hiroshi Okamoto, Shinji Takada
R-spondins (Rspos) are secreted proteins that modulate Wnt/β-catenin signaling. At the early stages of spinal cord development, Wnts (Wnt1, Wnt3a) and Rspos (Rspo1, Rspo3) are co-expressed in the roof plate, suggesting that Rspos are involved in development of dorsal spinal cord and neural crest cells in cooperation with Wnt ligands.
-
Primary cilia are critical for tracheoesophageal septation Dev. Dyn. (IF 2.5) Pub Date : 2023-09-30 Lindsey Avery Fitzsimons, Evangelia Tasouri, Marc August Willaredt, Daniel Stetson, Christian Gojak, Joachim Kirsch, Humphrey A. R. Gardner, Karin Gorgas, Kerry L. Tucker
Primary cilia play pivotal roles in the patterning and morphogenesis of a wide variety of organs during mammalian development. Here we examined murine foregut septation in the cobblestone mutant, a hypomorphic allele of the gene encoding the intraflagellar transport protein IFT88, a protein essential for normal cilia function.
-
Embryonic development in the bonnethead (Sphyrna tiburo), a viviparous hammerhead shark Dev. Dyn. (IF 2.5) Pub Date : 2023-09-28 Steven R. Byrum, Bryan S. Frazier, R. Dean Grubbs, Gavin J. P. Naylor, Gareth J. Fraser
The hammerhead sharks (family Sphyrnidae) are an immediately recognizable group of sharks due to their unique head shape. Though there has long been an interest in hammerhead development, there are currently no explicit staging tables published for any members of the group. The bonnethead Sphyrna tiburo is the smallest member of Sphyrnidae and is abundant in estuarine and nearshore waters in the Gulf
-
Development of the vertebra and fin skeleton in the lamprey and its implications for the homology of vertebrate vertebrae Dev. Dyn. (IF 2.5) Pub Date : 2023-09-21 Hirofumi Kariyayama, Natalia Gogoleva, Keishi Harada, Hiromasa Yokoyama, Hiroki Ono, Daichi G. Suzuki, Yuji Yamazaki, Hiroshi Wada
Although vertebrae are the defining character of vertebrates, they are found only in rudimentary form in extant agnathans. In addition, the vertebrae of agnathans possess several unique features, such as elastin-like molecules as the main matrix component and late (post-metamorphosis) differentiation of lamprey vertebrae. In this study, by tracing the developmental process of vertebrae in lamprey,
-
DLX gene expression in the developing chick pharyngeal arches and relationship to endothelin signaling and avian jaw patterning Dev. Dyn. (IF 2.5) Pub Date : 2023-09-14 Afshan Sohail, Andrew J. Bendall
A hinged jaw that articulates with the skull base is a striking feature of the vertebrate head and has been greatly modified between, and within, vertebrate classes. Genes belonging to the DLX homeobox family are conserved mediators of local signaling pathways that distinguish the dorsal and ventral aspects of the first pharyngeal arch. Specifically, a subset of DLX genes are expressed in the cranial
-
Characterization of p53/p63/p73 and Myc expressions during embryogenesis of the sea urchin Dev. Dyn. (IF 2.5) Pub Date : 2023-09-12 Blaine Grant, Paola Alejandra Sundaram Buitrago, Beatriz C. Mercado, Mamiko Yajima
Some marine invertebrate organisms are considered not to develop tumors due to unknown mechanisms. To gain an initial insight into how tumor-related genes may be expressed and function during marine invertebrate development, we here leverage sea urchin embryos as a model system and characterize the expressions of Myc and p53/p63/p73 which are reported to function synergistically in mammalian models
-
Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2) Dev. Dyn. (IF 2.5) Pub Date : 2023-09-09 Nicholas K. Bodmer, Russell H. Knutsen, Robyn A. Roth, Ryan M. Castile, Michael D. Brodt, Carrie M. Gierasch, Thomas J. Broekelmann, Mark A. Gibson, Jeffrey A. Haspel, Spencer P. Lake, Jeffrey R. Koenitzer, Steven L. Brody, Matthew J. Silva, Robert P. Mecham, David M. Ornitz
Latent TGFβ binding protein-2 (LTBP2) is a fibrillin 1 binding component of the microfibril. LTBP2 is the only LTBP protein that does not bind any isoforms of TGFβ, although it may interfere with the function of other LTBPs or interact with other signaling pathways.
-
Vertebral pattern and morphology is determined during embryonic segmentation Dev. Dyn. (IF 2.5) Pub Date : 2023-09-09 Kevin M. Serra, Christina Vyzas, Sarah Shehreen, Iris Chipendo, Katherine M. Clifford, Daniel W. Youngstrom, Stephen H. Devoto
The segmented nature of the adult vertebral column is based on segmentation of the paraxial mesoderm during early embryogenesis. Disruptions to embryonic segmentation, whether caused by genetic lesions or environmental stress, result in adult vertebral pathologies. However, the mechanisms linking embryonic segmentation and the details of adult vertebral morphology are poorly understood.
-
Cover Image Dev. Dyn. (IF 2.5) Pub Date : 2023-09-05 Lizbeth Ramírez-Vidal, Tonatiuh Molina-Villa, Valentín Mendoza, Carlos Alberto Peralta-Álvarez, Augusto Cesar Poot-Hernández, Dobromir Dotov, Fernando López-Casillas
-
Editorial highlights Dev. Dyn. (IF 2.5) Pub Date : 2023-09-05 Paul A. Trainor
Every organism is a model organism for understanding development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in Developmental Dynamics that illustrate the complex dynamics
-
SMAD4: A critical regulator of cardiac neural crest cell fate and vascular smooth muscle development Dev. Dyn. (IF 2.5) Pub Date : 2023-08-31 Brianna E. Alexander, Huaning Zhao, Sophie Astrof
During embryogenesis, cardiac neural crest-derived cells (NCs) migrate into the pharyngeal arches and give rise to the vascular smooth muscle cells (vSMCs) of the pharyngeal arch arteries (PAAs). vSMCs are critical for the remodeling of the PAAs into their final adult configuration, giving rise to the aortic arch and its arteries (AAAs).
-
Neural dependency in wound healing and regeneration Dev. Dyn. (IF 2.5) Pub Date : 2023-08-28 Alexandra Noble, Rozana Qubrosi, Solsa Cariba, Kayla Favaro, Samantha L. Payne
In response to injury, humans and many other mammals form a fibrous scar that lacks the structure and function of the original tissue, whereas other vertebrate species can spontaneously regenerate damaged tissues and structures. Peripheral nerves have been identified as essential mediators of wound healing and regeneration in both mammalian and nonmammalian systems, interacting with the milieu of cells
-
The sulfotransferase XB5850668.L is required to apportion embryonic ectodermal domains Dev. Dyn. (IF 2.5) Pub Date : 2023-08-19 Alexander Marchak, Karen M. Neilson, Himani D. Majumdar, Kiyoshi Yamauchi, Steven L. Klein, Sally A. Moody
Members of the sulfotransferase superfamily (SULT) influence the activity of a wide range of hormones, neurotransmitters, metabolites and xenobiotics. However, their roles in developmental processes are not well characterized even though they are expressed during embryogenesis. We previously found in a microarray screen that Six1 up-regulates LOC100037047, which encodes XB5850668.L, an uncharacterized
-
Cover Image Dev. Dyn. (IF 2.5) Pub Date : 2023-08-07 Homero L Cantu-Guerra, Michael R Papazian, Anna L Gorsky, Nathalie S Alekos, Adam Caccavano, Nare Karagulyan, Jakob Neef, Stefano Vicini, Tobias Moser, Thomas M Coate