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Genotoxic and neurotoxic potential of intracellular nanoplastics: A review J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-03-17 Claudio Casella, Santiago J. Ballaz
Plastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) of 1–100-nm size, thereby littering the environment and posing a threat to wildlife and human health. Research on NPL contamination has up to now focused on the ecotoxicology effects of the pollution rather than the health risks. This review aimed to speculate about the possible properties of
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Issue Information J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-03-18
No abstract is available for this article.
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CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-03-13 Sharoen Yu Ming Lim, Yan Pan, Mustafa Alshagga, Willone Lim, Kong Cin, Salah A. Alshehade, Mohammed Alshawsh
CYP‐14 members of the Caenorhabditis elegans (C. elegans) Cytochrome P450 (CYP) enzyme family, plays important roles in mitochondrial dysfunction, detoxification, lipid metabolism, defense and lifespan regulation. The review identifies CYP‐14 members: cyp‐14A1, cyp‐14A2, cyp‐14A3, cyp‐14A4, cyp‐14A5 and their homology with human CYP families. Despite limited studies on C. elegans cyp‐14 members, the
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Saikosaponin d protects pancreatic acinar cells against cerulein‐induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS‐STING pathway J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-03-11 Hui Chen, Xirong Lu, Beiqi Xu, Gang Cheng, Yuyi Li, Dan Xie
Acute pancreatitis represents an inflammatory disease featuring pancreatic necrosis and inflammation. Inflammatory injury of pancreatic acinar cells (PACs) is critically involved in the initiation and progression of acute pancreatitis. Pyroptosis, a new kind of programmed cell death concomitant with a low‐grade inflammatory reaction, plays a function in acute pancreatitis pathology. It is unclear whether
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Analysis of cantharidin-induced kidney injury and the protective mechanism of resveratrol in mice determined by liquid chromatography/mass spectrometry-based metabonomics J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-03-06 Yuanyuan Xiao, Ruxia Liu, Xiaoyue Zhang, Yaofeng Li, Fang Peng, Wenchao Tang
Cantharidin (CTD) is the main active component in the traditional Chinese medicine Mylabris and an effective anti-tumor agent. However, it is relatively toxic and exhibits nephrotoxicity, which limits its clinical use. However, its toxic mechanism is not clear. The toxic effects of CTD exposure on the kidney and the protective effect of resveratrol (RES) were studied in a mouse model, by determination
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Physiologically based pharmacokinetic modeling for confirming the role of CYP3A1/2 and P-glycoprotein in detoxification mechanism between glycyrrhizic acid and aconitine in rats J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-03-06 Jingyi Jin, Xiaoqing Xu, Fengling Li, Fengyi Weng, Bin Zou, Yue Li, Jing Zhao, Shuang Zhang, Dongming Yan, Furong Qiu
Fuzi, an effective common herb, is often combined with Gancao to treat disease in clinical practice with enhancing its efficacy and alleviating its toxicity. The major toxic and bioactive compounds in Fuzi and Gancao are aconitine (AC) and glycyrrhizic acid (GL), respectively. This study aims to elucidate detoxification mechanism between AC and GL from pharmacokinetic perspective using physiologically
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The flame retardant triphenyl phosphate alters the epigenome of embryonic cells in an aquatic in vitro model J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-02-29 Logan Germain, Louise M. Winn
Triphenyl phosphate (TPhP) is an organophosphate flame retardant and plasticizer that is added to a wide variety of consumer and industrial products. It is also a ubiquitous environmental pollutant. Exposure to TPhP has been shown to alter gene expression in metabolic and estrogenic signaling pathways in in vitro and in vivo models of a variety of species, and as such, is considered to be an endocrine
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ToxMPNN: A deep learning model for small molecule toxicity prediction J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-02-27 Yini Zhou, Chao Ning, Yijun Tan, Yaqi Li, Jiaxu Wang, Yuanyuan Shu, Songping Liang, Zhonghua Liu, Ying Wang
Machine learning (ML) has shown a great promise in predicting toxicity of small molecules. However, the availability of data for such predictions is often limited. Because of the unsatisfactory performance of models trained on a single toxicity endpoint, we collected toxic small molecules with multiple toxicity endpoints from previous study. The dataset comprises 27 toxic endpoints categorized into
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The enhanced hepatotoxicity of isobavachalcone in depigmented zebrafish due to calcium signaling dysregulation and lipid metabolism disorder J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-02-24 Huiwen Zhang, Chengyue Zhu, Jingcheng Zhao, Ruifang Zheng, Jianguo Xing, Zhijian Li, Yun Zhang, Qian Xu
Isobavachalcone (IBC) is a flavonoid component derived from Psoraleae Fructus that can increase skin pigmentation and treat vitiligo. However, IBC has been reported to be hepatotoxic. Current studies on IBC hepatotoxicity are mostly on normal organisms but lack studies on hepatotoxicity in patients. This study established the depigmented zebrafish model by using phenylthiourea (PTU) and investigated
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Low dose cadmium inhibits syndecan‐4 expression in glycocalyx of glomerular endothelial cells J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-02-24 Xianli Meng, Shuhui Xie, Jing Liu, Bingxuan Lv, Xin Huang, Qiang Liu, Xia Wang, Anna Malashicheva, Ju Liu
Cadmium (Cd) is one of the most polluting heavy metal in the environment. Cd exposure has been elucidated to cause dysfunction of the glomerular filtration barrier (GFB). However, the underlying mechanism remains unclear. C57BL/6J male mice were administered with 2.28 mg/kg cadmium chloride (CdCl2) dissolved in distilled water by oral gavage for 14 days. The expression of SDC4 in the kidney tissues
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Issue Information J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-02-12
No abstract is available for this article.
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The potential health risks of N,N-dimethylformamide: An updated review J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-02-10 Shu-Jun Hong, Xiu-Ning Zhang, Zhan Sun, Tao Zeng
N,N-dimethylformamide (DMF) is a universally used industrial material with exponential growth in production and consumption worldwide. The frequently reported occupational DMF poisoning cases in some countries and the gradually recognized unavoidable health risks to the general population highlight that DMF should still be a matter of concern. Previous studies have demonstrated that the liver is the
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In silico prediction of ocular toxicity of compounds using explainable machine learning and deep learning approaches J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-02-08 Yiqing Zhou, Ze Wang, Zejun Huang, Weihua Li, Yuanting Chen, Xinxin Yu, Yun Tang, Guixia Liu
The accurate identification of chemicals with ocular toxicity is of paramount importance in health hazard assessment. In contemporary chemical toxicology, there is a growing emphasis on refining, reducing, and replacing animal testing in safety evaluations. Therefore, the development of robust computational tools is crucial for regulatory applications. The performance of predictive models is heavily
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Protective effect of diindolylmethane-enriched dietary cabbage against doxorubicin-induced cardiotoxicity in mice J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-02-07 Jagadish Natesh, Priya Mondal, Dhanamjai Penta, Yahya Mukhlis, Devendra Jaganath Haware, Syed Musthapa Meeran
Chemotherapy with doxorubicin (Dox) can lead to cardiotoxic effects, presenting a major complication in cancer therapy. Diindolylmethane (DIM), derived from cruciferous vegetables like cabbage, exhibits numerous health benefits. However, its clinical application is limited because of low bioavailability and suboptimal natural concentrations in dietary sources. To address this limitation, we developed
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A systematic review focused on lubricant use and sperm quality: Improving human reproductive success by informing lubricants toxicity J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-31 Eloiza Adriane Dal Molin, Gabriel Adan Araújo Leite, Virgínia Meneghini Lazzari
Lubricants play a pivotal role in human reproductive health, particularly concerning their impact on sperm parameters. In this systematic review, we assess the implications of both synthetic and natural or organic lubricants on sperm health and fertility, based on a compilation of 20 distinct studies. Synthetic lubricants, including K-Y Jelly, Replens, and Astroglide, predominantly containing ingredients
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Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced liver injury J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-30 Saori Tanaka, Takumi Noda, Kazuya Urashima, Yoshio Ijiri, Yuka Kohda, Ryuji Kato
Trovafloxacin is a quinolone antibiotic drug with broad-spectrum activity, which was withdrawn from a global market relatively soon after approval because of serious liver injury. The characteristics of trovafloxacin-induced liver injury are consistent with an idiosyncratic reaction; however, the details of the mechanism have not been elucidated. We examined whether trovafloxacin induces the release
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Titanium dioxide nanoparticles induce apoptosis through ROS-Ca2+-p38/AKT/mTOR pathway in TM4 cells J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-25 Qianqian Wang, Yaqian Yang, Pengfei Li, Ruoyun Dong, Chenhao Sun, Guanling Song, Yan Wang
Titanium dioxide nanoparticles (TiO2 NPs) can cause apoptosis in TM4 cells; however, the underlying mechanism has not been entirely elucidated. The purpose of this study was to investigate the effects of TiO2 NPs on ROS, Ca2+ level, p38/AKT/mTOR pathway, and apoptosis in TM4 cells and to evaluate the role of Ca2+ in p38/AKT/mTOR pathway and apoptosis. After exposure to different concentrations (0,
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Poison in the water: Arsenic's silent assault on fish health J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-23 Meenakshi Chandel, Amit Kumar Sharma, Kushal Thakur, Dixit Sharma, Bhavna Brar, Danish Mahajan, Hishani Kumari, Pranay Punj Pankaj, Rakesh Kumar
Arsenic occurs across the world in freshwater and marine environments, menacing the survival of aquatic organisms. Organic and inorganic forms of this substance can be found, in which the inorganic form is more hazardous than the organic form. Most aquatic bodies contain inorganic arsenic species, but organic species are believed to be the dominant form of arsenic in the majority of fish. Natural and
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A novel alternative method for long-term evaluation of male reproductive toxicity and its recovery using a pre-pubertal mouse testis organ culture system J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-23 Kiyoshi Hashimoto, Hiroshi Arakawa, Rikako Imamura, Takuya Nishimura, Satoshi Kitajima, Takuya Sato, Kazuhide Makiyama, Takehiko Ogawa, Satoshi Yokota
Successful treatment of pediatric cancers often results in long-term health complications, including potential effects on fertility. Therefore, assessing the male reproductive toxicity of anti-cancer drug treatments and the potential for recovery is of paramount importance. However, in vivo evaluations are time-intensive and require large numbers of animals. To overcome these constraints, we utilized
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Nitrophenols disrupt the expression and activity of biotransformation enzymes (CYP3A and COMT) in chicken ovarian follicles in vivo and in vitro J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-18 Anna Kozubek, Dorota Katarzyńska-Banasik, Kinga Kowalik, Agnieszka K. Grzegorzewska, Anna Hrabia, Andrzej Sechman
Nitrophenols are environmental pollutants and xenobiotics, the main sources of which are diesel exhaust fumes and pesticides. The biotransformation processes that take place in the liver are defence mechanisms against xenobiotics, such as nitrophenols. Our previous study showed that the chicken ovary is an additional xenobiotic detoxification place and that nitrophenols disrupt steroidogenesis in chicken
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Preclinical toxicity evaluation of novel antibacterial contezolid acefosamil in rats and dogs J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-18 Wen Wang, Zhengyao Li, Mikhail F. Gordeev, Hong Yuan
Contezolid acefosamil (CZA) is an intravenous prodrug of oxazolidinone antibiotic contezolid (CZD). It is being developed to treat infections due to Gram-positive bacteria including multidrug-resistant pathogens, while addressing myelosuppression and neurotoxicity limitations associated with long-term use of this class of antibiotics. In vivo, CZA is rapidly deacylated into its first metabolite MRX-1352
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Anti-Candida activity and in vitro toxicity screening of antifungals complexed with β-cyclodextrin J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-10 Gustavo Simão Moraes, Nathaly Mayer Tozetto, Thaynara Aparecida Alves Pedroso, Marcela Alves de Mattos, Amanda Migliorini Urban, Katia Sabrina Paludo, Fábio André dos Santos, Karin Hermana Neppelenbroek, Vanessa Migliorini Urban
The emergence of resistant fungal species and the toxicity of currently available antifungal drugs are relevant issues that require special consideration. Cyclodextrins inclusion complexes could optimize the antimicrobial activity of such drugs and create a controlled release system with few side effects. This study aimed to assess the in vitro toxicity and antifungal effectiveness of nystatin (Nys)
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Featured Cover J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-12 Natália Bernardi Videira, Vijayalekshmi Nair, Valérie Paquet, Dean Calhoun
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Issue Information J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-12
No abstract is available for this article.
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A systematic review on multipotent carcinogenic agent, N-nitrosodiethylamine (NDEA), its major risk assessment, and precautions J. Appl. Toxicol. (IF 3.3) Pub Date : 2024-01-11 Pracheta Janmeda, Divya Jain, Priya Chaudhary, Mukesh Meena, Devendra Singh
The International Agency for Research on Cancer has classified N-nitrosodiethylamine (NDEA) as a possible carcinogen and mutagenic substances, placing it in category 2A of compounds that are probably harmful to humans. It is found in nature and tobacco smoke, along with its precursors, and is also synthesized endogenously in the human body. The oral or parenteral administration of a minimal quantity
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Inefficacy of dietary test substance administration in Amphibian Metamorphosis Assay (AMA) studies J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-27 Douglas J. Fort, Jeffrey C. Wolf, Angelika Langsch, Beate Fast, Markus Junker, Rainer Otter
Traditionally, the Amphibian Metamorphosis Assay (AMA; OECD TG 231) is performed by exposing Xenopus laevis tadpoles to test substances dissolved in laboratory water. Recently, the use of dietary administration has been proposed to combat poorly soluble test substances in ecotoxicologically-based regulatory endocrine disruption (ED) studies, specifically the AMA warranting an investigation into the
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Arzanol, a natural phloroglucinol α-pyrone, protects HaCaT keratinocytes against H2O2-induced oxidative stress, counteracting cytotoxicity, reactive oxygen species generation, apoptosis, and mitochondrial depolarization J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-27 Franca Piras, Valeria Sogos, Federica Pollastro, Giovanni Appendino, Antonella Rosa
Skin oxidative stress results in structural damage, leading to premature senescence, and pathological conditions such as inflammation and cancer. The plant-derived prenylated pyrone–phloroglucinol heterodimer arzanol, isolated from Helichrysum italicum ssp. microphyllum (Willd.) Nyman aerial parts, exhibits anti-inflammatory, anticancer, antimicrobial, and antioxidant activities. This study explored
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Lithium salts cytotoxicity and accumulation in melanoma cells in vitro J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-26 Iuliia Taskaeva, Anna Kasatova, Ivan Razumov, Nataliya Bgatova, Sergey Taskaev
Boron neutron capture therapy is a perspective selective technology for the destruction of cancer cells, while the use of lithium instead of boron may represent a new and promising vector for the development of neutron capture therapy (NCT). The aim of the study was a comparative assessment of the cytotoxicity of various lithium salts, as well as an analysis of the accumulation of lithium in tumor
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In ovo o,p′-DDT exposure induces malformation of reproductive organs and alters the expression of genes controlling sexual differentiation in Japanese quail embryo J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-15 Tin-Tin Win-Shwe, Natsuko Abe, Akari Sakiyama, Maho Suzuki, Kazuhiro Sano, Takaharu Kawashima, Shinji Tsukahara
In ovo exposure to o,p′-dichloro-diphenyl-trichloroethane (o,p′-DDT) impairs reproduction by inducing malformation of the reproductive organs in birds, although the mechanism remains unclear. Here, we examined the effects of o,p′-DDT on the development of the reproductive organs, the expression of genes controlling sexual differentiation, and the plasma concentrations of testosterone and estradiol
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Epigallocatechin gallate alleviated the in vivo toxicity of ZnO nanoparticles to mouse intestine J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-14 Canyang Wang, Chaobo Huang, Yi Cao
To evaluate the oral toxicity of nanoparticles (NPs), it is necessary to consider the interactions between NPs and nutrient molecules. Recently, we reported that epigallocatechin gallate (EGCG), a healthy component in green tea, alleviated the toxicity of ZnO NPs to 3D Caco-2 spheroids in vitro. The present study investigated the combined effects of EGCG and ZnO NPs to mice in vivo. Mice were administrated
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Exposure of quantum dots in the nervous system: Central nervous system risks and the blood–brain barrier interface J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-08 Shujing Guan, Meng Tang
Quantum dots currently possess significant importance in the field of biomedical science. Upon introduction into the body, quantum dots exhibit a tendency to accumulate in diverse tissues including the central nervous system (CNS). Consequently, it becomes imperative to devote specific attention to their potential toxic effects. Moreover, the preservation of optimal CNS function relies heavily on blood–brain
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Modified ESR-based photosafety test (ESR-PT) detecting singlet oxygen and free radical formation J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-06 Masumi Hinoshita, Takayuki Abe, Asako Sato, Yosuke Maeda, Masahiro Takeyoshi
The electron spin resonance-based photosafety test (ESR-PT) was modified using a new parameter, photoreactivity index (PRI), to detect singlet oxygen and free radical photoproducts simultaneously. With this modification, the modified ESR-PT is expected to reduce the number of false negative results due to chemicals producing free radical photoproducts other than singlet oxygen. The assay performance
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Quercetin ameliorates Helicobacter pylori-induced gastric epithelial cell injury by regulating specificity protein 1/lipocalin 2 axis in gastritis J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-06 Ziwei Wang, Xinxin Zhou, Xin Hu, Congru Zheng
Helicobacter pylori (HP) infection is the main cause of most cases of gastritis. Quercetin has been shown to have anti-inflammatory, anti-bacterial, and antiviral activities and has been demonstrated to be involved in HP-induced gastric mucosa injury. Moreover, the secretory protein lipocalin-2 (LCN2) was elevated in HP-infected gastric mucosa. Thus, this work aimed to study the interaction between
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Pitavastatin induces caspase-mediated apoptotic death through oxidative stress and DNA damage in combined with cisplatin in human cervical cancer cell line J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-06 Aysun Ökçesiz Hacıseyitoğlu, Tuğbagül Çal Doğan, Sevtap Aydın Dilsiz, Hande Canpınar, Ayşe Eken, Ülkü Ündeğer Bucurgat
Pitavastatin (PITA) is a 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor to treat hypercholesterolemia and in recent studies is focused that its potential anti-cancer effect. This study was aimed to elucidate the effect of PITA alone and in combination with cisplatin on cervical cancer cells (HeLa) in vitro. Cytotoxicity of PITA (5–200 μM) was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2
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Issue Information J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-12-05
No abstract is available for this article.
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Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum-induced neurotoxicity in an in vitro Alzheimer's disease model J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-11-21 Göksun Demirel, Sonia Sanajou, Anil Yirün, Deniz Arca Çakir, Aysel Berkkan, Terken Baydar, Pinar Erkekoğlu
Alzheimer's disease (AD) is a progressive neurological disorder that affects various cognitive functions, behavior, and personality. AD is thought to be caused by a combination of genetic and environmental factors, including exposure to aluminum (Al). Virgin coconut oil (VCO) may have potential as a natural neuroprotectant against AD. Aim of this study was to determine neuroprotective effects of VCO
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Allocholic acid protects against α-naphthylisothiocyanate-induced cholestasis in mice by ameliorating disordered bile acid homeostasis J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-11-15 Xue Han, Chuyi Lin, Huijie Liu, Shan Li, Bei Hu, Lei Zhang
Cholestasis is a pathological condition characterized by disruptions in bile flow, leading to the accumulation of bile acids (BAs) in hepatocytes. Allocholic acid (ACA), a unique fetal BA known for its potent choleretic effects, reappears during liver regeneration and carcinogenesis. In this research, we investigated the protective effects and underlying mechanisms of ACA against mice with cholestasis
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Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-11-15 Z. Sobańska, K. Sitarek, J. Gromadzińska, R. Świercz, M. Szparaga, K. Domeradzka-Gajda, K. Kowalczyk, L. Zapór, W. Wąsowicz, J. Grobelny, K. Ranoszek-Soliwoda, E. Tomaszewska, G. Celichowski, J. Roszak, M. Stępnik
In this study, molybdenum(IV) sulfide (MoS2) nanoparticles (97 ± 32 nm) and microparticles (1.92 ± 0.64 μm) stabilized with poly (vinylpolypyrrolidone) (PVP) were administered intratracheally to male and female rats (dose of 1.5 or 5 mg/kg bw), every 14 days for 90 days (seven administrations in total). Blood parameters were assessed during and at the end of the study (hematology, biochemistry including
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Using particle dimensionality-based modeling to estimate lung carcinogenicity of 3D printer emissions J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-11-11 Andrey A. Korchevskiy, W. Cary Hill, Matthew Hull, Arseniy Korchevskiy
The use of 3D printing technologies by industry and consumers is expanding. However, the approaches to assess the risk of lung carcinogenesis from the emissions of 3D printers have not yet been developed.
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The involvement of calcium in the toxic effect of 4-methylethcathinone on SH-SY5Y cells J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-11-11 Wei Zhang, Fangqi Cao, Ming Li, Zhiwen Xu, Jing Sun, Zhiwei Huang, Ping Shi
Neurotoxicity induced by psychoactive substances is often accompanied by an imbalance of intracellular calcium ions. It is unclear whether calcium ions play a role in the toxicity induced by psychoactive substances. In the present study, we aimed to evaluate the occurrence of calcium dysregulation and its contribution to cytotoxicity in human neurotypic SH-SY5Y cells challenged with a recently developed
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Issue Information J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-11-09
No abstract is available for this article.
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A comparative study on chromium-induced micronuclei assessment in the peripheral blood of Hsd:ICR mice J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-31 María del Carmen García-Rodríguez, Lourdes Montserrat Hernández-Cortés, Ana Rosa Montaño-Rodríguez, Pedro Salvador Pereyra-Mejía, Sam Kacew
This study investigated the genotoxic effects of chromium (Cr) in Hsd:ICR mice, considering factors such as oxidative state, apoptosis, exposure pathway, duration, pregnancy, and transplacental exposure. Genotoxicity was assessed using the erythrocytes' micronucleus (MN) assay, while apoptosis was evaluated in nucleated blood cells. The results showed that Cr(III) (CrK(SO4)2 and CrCl3) did not induce
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Effect of lanthanum nitrate on adipogenesis in mice J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-31 Yuhong Ma, Qianqian Xiao, Chenping Kang, Lilan Yuan, Zhe Zhao, Xiaoxia Wang, Qianyi Liu, Wanqian Guo, Xuetao Wei, Weidong Hao
Lanthanum (La) is widely used in modern industry and agriculture because of its unique physicochemical properties and is broadly exposed in the population. Some studies have shown that La may have some effects on adipogenesis, but there is a lack of related in vivo evidence. In this study, the effects of La(NO3)3 on adipogenesis and its associated mechanism were studied using C57BL/6J mouse model.
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The inter-laboratory validation study of EpiSensA for predicting skin sensitization potential J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-28 Hideyuki Mizumachi, Mika Watanabe, Mayu Ikezumi, Michika Kajiwara, Michiyo Yasuda, Makoto Mizuno, Noriyasu Imai, Megumi Sakuma, Momoko Shibata, Shin-ichi Watanabe, Junko Motoyama, David Basketter, Chantra Eskes, Sebastian Hoffmann, David M. Lehmann, Takao Ashikaga, Takashi Sozu, Masahiro Takeyoshi, Sho Suzuki, Masaaki Miyazawa, Hajime Kojima
The Epidermal Sensitization Assay (EpiSensA) is a reconstructed human epidermis (RhE)-based gene expression assay for predicting the skin sensitization potential of chemicals. Since the RhE model is covered by a stratified stratum corneum, various kinds of test chemicals, including lipophilic ones and pre-/pro-haptens, can be tested with a route of exposure akin to an in vivo assay and human exposure
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Impact of inhalation exposure to cigarette smoke on the pathogenesis of pulmonary hypertension primed by monocrotaline in rats J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-24 Jung-Min Park, Yoon-Seok Seo, Sung-Hwan Kim, Hyeon-Young Kim, Min-Seok Kim, Moo-Yeol Lee
Extensive, long-term exposure to cigarette smoke (CS) was recently suggested to be a risk factor for pulmonary hypertension, although further validation is required. The vascular effects of CS share similarities with the etiology of pulmonary hypertension, including vascular inflammation and remodeling. Thus, we examined the influence of CS exposure on the pathogenesis of monocrotaline (MCT)-induced
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Role of CD44 expressed in renal tubules during maladaptive repair in renal fibrogenesis in an allopurinol-induced rat model of chronic kidney disease J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-24 Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa
The kidney is a major target organ for the adverse effects of pharmaceuticals; renal tubular epithelial cells (TECs) are particularly vulnerable to drug-induced toxicity. TECs have regenerative capacity; however, maladaptive repair of TECs after injury leads to renal fibrosis, resulting in chronic kidney disease (CKD). We previously reported the specific expression of CD44 in failed-repair TECs of
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Protection of schisantherin A against dictamnine-induced hepatotoxicity: Pharmacokinetic insights J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-24 Xiaojin Chang, Guangyao Li, Bufan Yang, Dongju Lin
Dictamnine (DIC), as the most abundant furoquinoline alkaloid ingredient of the herbal medicine Cortex Dictamni (CD), can induce severe liver injury. A previous study found that DIC-induced liver injury was initiated by cytochrome P4503A (CYP3A)-mediated metabolic activation and subsequent formation of adducts with cellular proteins. Schisantherin A (SchA) is the major lignan component of the herbal
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Issue Information J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-16
No abstract is available for this article.
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Reconstructed human epidermis-based testing strategy of skin sensitization potential and potency classification using epidermal sensitization assay and in silico data J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-17 Hideyuki Mizumachi, Sho Suzuki, Megumi Sakuma, Midori Natsui, Noriyasu Imai, Masaaki Miyazawa
The hazards and potency of skin sensitizers are traditionally determined using animal tests such as the local lymph node assay (LLNA); however, significant progress has been made in the development of non-animal test methods addressing the first three mechanistic key events of adverse outcome pathway in skin sensitization. We developed the epidermal sensitization assay (EpiSensA), which is a reconstructed
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Genotoxicity of bisphenol AF in rats: Detrimental to male reproductive system and probable stronger micronucleus induction potency than BPA J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-14 Xia Zhu, Li Cao, Yufei Liu, Xinyao Tang, Yeqiu Miao, Jing Zhang, Lishi Zhang, Zhenchao Jia, Jinyao Chen
Bisphenol AF (BPAF), as one of structural analogs of BPA, has been increasingly used in recent years. However, limited studies have suggested its adverse effects similar to or higher than BPA. In order to explore the general toxicity and genotoxicity of subacute exposure to BPAF, the novel 28-day multi-endpoint (Pig-a assay + micronucleus [MN] test + comet assay) genotoxicity evaluation platform was
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Species differences in small intestinal exposure-related epithelial vacuolation in rats and dogs treated with a heteroaryldihydropyrimidine molecule J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-09 Jieyu Dai, Tao Chen, Ryan Meng, Ferran Jardi, Stephanie Kourula, Ly Pham, Sandra De Jonghe, Ann De Smedt, Anna-Lena Frisk, Jianxun Xie
Small intestinal epithelial vacuolation induced by a heteroaryldihydropyrimidine compound (HAP-1) was observed in rats but not in dogs at termination in screening toxicity studies, despite the plasma exposure being higher in dogs. To understand the species differences, investigational studies with multiple time points following single dose (SD) and 7-day repeated dose (RD) were conducted in both species
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Lowering the pH leads to the disaggregation of NiO and ZnO nanoparticles and modifies the mutagenic response J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-12 Ismael Krüger Pescke, Lívia de Oliveira Rozino, Karoline Zenato, Tatiane Cardozo, Wladimir Hernandez Flores, Vera Maria Ferrão Vargas
In a changing environmental scenario, acid rain can have a significant impact on aquatic ecosystems. Acidification is known to produce corrosion in metals, hence increasing their harmful effects on the environment, organisms and human health. The prevalent use of metallic nanoparticles (NPs) in everyday products raises concerns regarding exposure and nanotoxicity even in these acidified conditions
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Inhibition of voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells by the atypical antipsychotic agent sertindole J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-10-03 Wenwen Zhuang, Seo-Yeong Mun, Minju Park, Junsu Jeong, Hye Ryung Kim, Sunghun Na, Se Jin Lee, Hongzoo Park, Won Sun Park
The regulation of membrane potential and the contractility of vascular smooth muscle cells (VSMCs) by voltage-dependent K+ (Kv) potassium channels are well-established. In this study, native VSMCs from rabbit coronary arteries were used to investigate the inhibitory effect of sertindole, an atypical antipsychotic agent, on Kv channels. Sertindole induced dose-dependent inhibition of Kv channels, with
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Dual effects of endogenous formaldehyde on the organism and drugs for its removal J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-09-27 Jiaxin Chen, Wenhui Chen, Jinjia Zhang, Huanhuan Zhao, Ji Cui, Junzi Wu, Anhua Shi
Endogenous formaldehyde (FA) is produced in the human body via various mechanisms to preserve healthy energy metabolism and safeguard the organism. However, endogenous FA can have several negative effects on the body through epigenetic alterations, including cancer growth promotion; neuronal, hippocampal and endothelial damages; atherosclerosis acceleration; haemopoietic stem cell destruction and haemopoietic
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The repeated administration of rhIL-12 for 14 weeks in rhesus monkeys: A toxicity assessment J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-09-28 Huiqin Ding, Huan Qin, Jiangang Wang, Yansheng Dong, Quanjun Wang, Yantao Han
Interleukin-12 (IL-12) is known to exert antitumor immune effects by promoting the activation and proliferation of T cells and NK cells within the immune system. However, clinical trials have observed systemic toxicity associated with the administration of IL-12. This has shelved development plans for its use as a cancer therapeutic drug. Therefore, it is critical that we perform a systematic evaluation
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In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of Drosophila melanogaster larval brain J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-09-21 Fatma Turna Demir, Eşref Demir
Agriculture commonly utilizes crop protection products to tackle infestations from fungi, parasites, insects, and weeds. Validamycin A, an inhibitor of trehalase, possesses antibiotic and antifungal attributes. Epidemiological evidence has led to concerns regarding a potential link between pesticide usage and neurodegenerative diseases. The fruit fly, Drosophila melanogaster, has been recognized as
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Nonclinical safety assessment of an mRNA Covid-19 vaccine candidate following repeated administrations and biodistribution J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-09-18 Karine Broudic, Sébastien Laurent, Vladimir Perkov, Charlene Simon, Marie Garinot, Nathalie Truchot, Julie Latour, Paul Désert
Messenger RNA (mRNA) vaccines have demonstrated efficacy against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in humans. mRNA technology holds tremendous potential for rapid control and prevention of emergencies due to its flexibility with respect to production, application, and design for an efficacious and safe use in humans. We assessed the toxicity and biodistribution of MRT5500
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Issue Information J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-09-15
No abstract is available for this article.
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Narcissin induces developmental toxicity and cardiotoxicity in zebrafish embryos via Nrf2/HO-1 and calcium signaling pathways J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-09-17 Shuo Gao, Chaoyi Zhou, Linhua Hou, Kuo Xu, Yun Zhang, Xue Wang, Jianheng Li, Kechun Liu, Qing Xia
Narcissin is a natural flavonoid from some edible and traditional medicinal plants. It has been proven to have multiple biological functions and exhibits potential therapeutic effects on hypertension, cancer, and Alzheimer's disease. However, the toxicity of narcissin is largely unknown. Here, we revealed that narcissin treatment led to reduced hatchability, increased malformation rate, shorter body
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Developmental and reproductive toxicity hazard characterization of 2-amino-2-methyl-1-propanol (AMP) J. Appl. Toxicol. (IF 3.3) Pub Date : 2023-09-16 Lindsey Garnick, Christopher Bates, Andrey Massarsky, Pamela Spencer, Priyanka Sura, Andrew D. Monnot, Andrew Maier
2-Amino-2-methyl-1-propanol (AMP™) is a widely used pH stabilizer in personal care products (PCPs); thus, the safety implications of dermal AMP exposure remain of interest. We have previously reported that exposure to AMP in PCPs when used as intended is not anticipated to result in an increased risk of hepatotoxicity (primarily steatosis and altered phospholipid homeostasis). The current study focuses