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Exposure to prenatal stressors and infant autonomic nervous system regulation of stress Stress (IF 2.3) Pub Date : 2024-03-18 Sandra J. Weiss, Bruce Cooper, Cherry Leung
The purpose of this study was to determine the relationship between fetal exposure to maternal prenatal stressors and infant parasympathetic (PNS) and sympathetic (SNS) nervous function at 3 timepo...
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Sex differences in body temperature and neural power spectra in response to repeated restraint stress Stress (IF 2.3) Pub Date : 2024-02-28 I. C. Ravaglia, V. Jasodanand, S. Bhatnagar, L. A. Grafe
Repeated stress is associated with an increased risk of developing psychiatric illnesses such as post-traumatic stress disorder (PTSD), which is more common in women, yet the neurobiology behind th...
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Multi-omics in stress and health research: study designs that will drive the field forward Stress (IF 2.3) Pub Date : 2024-02-29 Summer Mengelkoch, Jeffrey Gassen, Shahar Lev-Ari, Jenna C. Alley, Sophia Miryam Schüssler-Fiorenza Rose, Michael P. Snyder, George M. Slavich
Despite decades of stress research, there still exist substantial gaps in our understanding of how social, environmental, and biological factors interact and combine with developmental stressor exp...
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Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males Stress (IF 2.3) Pub Date : 2024-02-20 Yaxin Fan, Yifen Cui, Rongxiang Tang, Amar Sarkar, Pranjal Mehta, Yi-Yuan Tang
Stress is an established risk factor for negative health outcomes. Salivary cortisol and testosterone concentrations increase in response to acute psychosocial stress. It’s crucial to reduce stress...
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Prenatal exposure to social adversity and infant cortisol in the first year of life Stress (IF 2.3) Pub Date : 2024-02-20 Victoria F. Keeton, Thomas J. Hoffmann, Kalisha Moneé Goodwin, Bree Powell, Sophia Tupuola, Sandra J. Weiss
Exposure to social adversity has been associated with cortisol dysregulation during pregnancy and in later childhood; less is known about how prenatal exposure to social stressors affects postnatal...
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Chronic restraint stress induces abnormal behaviors in pain sensitivity and cognitive function in mice: the role of Keap1/Nrf2 pathway Stress (IF 2.3) Pub Date : 2024-02-20 Ning Yang, Yue Wang, Xiaoxiao Luo, Gaofeng Zhan
Stress is a series of physical and psychological responses to external and internal environmental stimuli. Growing studies have demonstrated the detrimental impacts of acute restraint stress (ARS) ...
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How an appreciation of dynamics has altered our understanding of the HPA axis Stress (IF 2.3) Pub Date : 2024-01-23 Stafford Lightman, Thomas Upton
Rhythmicity is a intrinsic feature of biological systems, including the hypothalamic-pituitary-adrenal axis, a mammalian neurohormonal system crucial both in daily life and as a network that respon...
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HIV status affects PTSD symptom severity, psychophysiology, and heart rate variability in women with low but not high exposure to childhood maltreatment Stress (IF 2.3) Pub Date : 2024-01-18 Vasiliki Michopoulos, Mariana Rocha, Rebecca Hinrichs, Susie Turkson, Samya Dyer, Paul Howell, Elizabeth C. Heaton, Jakayla Hart, Abigail Powers, Yara Mekawi, Sierra Carter, Ighovwerha Ofotokun, Tanja Jovanovic, Gretchen N. Neigh
People living with HIV (PLWH) experience high rates of childhood maltreatment, which increases risk for posttraumatic stress disorder (PTSD). Thus, it is important to understand how HIV status inte...
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Behavior, synaptic mitochondria, and microglia are differentially impacted by chronic adolescent stress and repeated endotoxin exposure in male and female rats Stress (IF 2.3) Pub Date : 2024-01-05 A. J. Wegener, M. M. Hyer, I. Targett, A. Kloster, G. A. Shaw, A. M. M. Rodriguez, S. K. Dyer, G. N. Neigh
Early life adversity and chronic inflammation have both been associated with cognitive impairment and neural compromise. In this study, we investigated the interactions between a history of chronic...
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Accumbal μ-opioid receptors and salt taste-elicited hedonic responses in a rodent model of prenatal adversity, and their correlates using human functional genomics Stress (IF 2.3) Pub Date : 2023-12-22 Adrianne Rahde Bischoff, Roberta Dalle Molle, Amanda Brondani Mucellini, Irina Pokhvisneva, Robert D. Levitan, Michael J. Meaney, Patrícia P. Silveira
Prenatal adversity is associated with behavioral obesogenic features such as preference for palatable foods. Salt appetite may play a role in the development of adiposity and its consequences in in...
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Decreased amygdala-sensorimotor connectivity mediates the association between prenatal stress and broad autism phenotype in young adults: Project Ice Storm Stress (IF 2.3) Pub Date : 2023-12-22 Xinyuan Li, Muhammad Naveed Iqbal Qureshi, David P. Laplante, Guillaume Elgbeili, Vincent Paquin, Sherri Lee Jones, Suzanne King, Pedro Rosa-Neto
Studies show that prenatal maternal stress (PNMS) is related to risk for child autism, and to atypical amygdala functional connectivity in the autistic child. Yet, it remains unclear whether amygda...
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Maternal prenatal distress exposure negatively associates with the stability of neonatal frontoparietal network Stress (IF 2.3) Pub Date : 2023-12-09 Jetro J. Tuulari, Olli Rajasilta, Joana Cabral, Morten L. Kringelbach, Linnea Karlsson, Hasse Karlsson
Maternal prenatal distress (PD), frequently defined as in utero prenatal stress exposure (PSE) to the developing fetus, influences the developing brain and numerous associations between PSE and bra...
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Stress in performance-related pay: the effect of payment contracts and social-evaluative threat Stress (IF 2.3) Pub Date : 2023-11-27 Nicole Andelic, Julia Allan, Keith A. Bender, Daniel Powell, Ioannis Theodossiou
There is some evidence that performance-related pay (PRP) leads to higher levels of stress as it incentivizes employees to work harder for longer. However, PRP in the workplace also typically invol...
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Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats Stress (IF 2.3) Pub Date : 2023-11-05 J. Alex Grizzell, Maryam Vanbaelinghem, Jessica Westerman, Michael P. Saddoris
Alcohol use during adolescence coincides with elevated risks of stress-related impairment in adults, particularly via disrupted developmental trajectories of vulnerable corticolimbic and mesolimbic...
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The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat Stress (IF 2.3) Pub Date : 2023-10-30 Onno C. Meijer, Sander Kooijman, Jan Kroon, Elizabeth M. Winter
Glucocorticoid hormones are essential for health, but overexposure may lead to many detrimental effects, including metabolic, psychiatric, and bone disease. These effects may not only be due to inc...
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Effects of chronic stress on bladder morphology of rats and impact of comfort food diet as an ameliorating agent Stress (IF 2.3) Pub Date : 2023-10-07 Roger G. Marchon, Bianca M. Gregório, Marco A. Pereira-Sampaio, Waldemar S. Costa, Francisco J. Sampaio, Diogo B. De Souza
To investigate the effects of chronic stress on bladder morphology and the impact of food preference (standard or comfort foods) on the bladder of stressed rats.In total, 32 Wistar male rats (3 mon...
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Stress, rhythm, choice and the munchies – tribute to Mary F. Dallman Stress (IF 2.3) Pub Date : 2023-10-03 Susanne E. la Fleur
In December 2021, we lost a pioneer in the field of stress research who inspired generations of scientists. Mary Dallman was an expert on the hypothalamic-pituitary-adrenal (HPA) axis, its interact...
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Occupational stress is associated with sex and subregion specific modifications of the amygdala volumes Stress (IF 2.3) Pub Date : 2023-09-28 Nilab Nasrullah, B Khorashad Sorouri, Anton Lundmark, Rene Seiger, Ivanka Savic
Background: Despite the rapid increase in reports of exhaustion syndrome (ES) due to daily occupational stress, the mechanisms underlying ES are unknown. In the present study, we investigated wheth...
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Early life adversity ablates sex differences in active versus passive threat responding in mice Stress (IF 2.3) Pub Date : 2023-09-13 Gabriela Manzano Nieves, Marilyn Bravo, Kevin G. Bath
Early life adversity (ELA) heightens the risk for anxiety disorders (which are characterized by heightened fear and avoidance behaviors), with females being twice as likely as males to develop path...
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CCK1R2R-/- ameliorates myocardial damage caused by unpredictable stress via altering fatty acid metabolism Stress (IF 2.3) Pub Date : 2023-09-08 Zhi-Hua Zhang, Chen-Teng Yang, Xiao-Rui Su, Ya-Ping Li, Xiao-Jing Zhang, Song-Jun Wang, Bin Cong
The heart is the main organ of the circulatory system and requires fatty acids to maintain its activity. Stress is a contributor to aggravating cardiovascular diseases and even death, and exacerbat...
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Diverse roles of glucocorticoids in the ruminant mammary gland: modulation of mammary growth, milk production, and mastitis Stress (IF 2.3) Pub Date : 2023-09-01 Xiaoyue Ma, Hanling Liu, Qianqian Jia, Yumiao Zheng, Wentao Li, Mengyu Chang, Haixia Fu, Hongmei Zhu
As endocrine hormones, glucocorticoids (GCs) play a pivotal role in numerous physiological processes, including mammary growth and lactation, circulatory metabolism, and responses to external stimu...
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Positive affect and resilience in tertiary education students Stress (IF 2.3) Pub Date : 2023-08-31 David Tuck, Joshua Wiley, Lefteris Patlamazoglou, Emily Berger
Abstract Mental illnesses are the greatest health problems faced by younger people. As a group, tertiary education students demonstrate higher levels of distress than their age matched peers who are not tertiary students, making them an at-risk group for the development of psychopathology. Therefore, this study investigates existing theories of resilience in order to determine how it may be promoted
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Norepinephrine promotes neuronal apoptosis of hippocampal HT22 cells by up-regulating the expression of long non-coding RNA MALAT1 Stress (IF 2.3) Pub Date : 2023-08-30 Ying Wang, Hui Hu, Yuhan Wu, Yun Zhao, Fang Xie, Zhaowei Sun, Xue Wang, Lingjia Qian
Stress is ever present in our modern, performance-oriented and demanding society, which causes adverse stress reactions of the body and affects health seriously. Chronic stress has been recognized ...
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Glucocorticoid feedback paradox: a homage to Mary Dallman Stress (IF 2.3) Pub Date : 2023-08-23 Edo Ronald de Kloet
Abstract As the end product of the hypothalamus-pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone coordinate circadian activities, stress-coping, and adaptation to change. For this purpose, the hormone promotes energy metabolism and controls defense reactions in the body and brain. This life-sustaining action exerted by glucocorticoids occurs in concert with the
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Female rats are more responsive than are males to the protective effects of voluntary physical activity against the behavioral consequences of inescapable stress Stress (IF 2.3) Pub Date : 2023-08-23 Margaret K. Tanner, Alyssa A. Hohorst, Simone M. Mellert, Esteban C. Loetz, Michael V. Baratta, Benjamin N. Greenwood
Abstract Common stress-related mental health disorders affect women more than men. Physical activity can provide protection against the development of future stress-related mental health disorders (i.e. stress resistance) in both sexes, but whether there are sex differences in exercise-induced stress resistance is unknown. We have previously observed that voluntary wheel running (VWR) protects both
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Psychological, endocrine and polygenic predictors of emotional well-being during the COVID-19 pandemic in a longitudinal birth cohort Stress (IF 2.3) Pub Date : 2023-08-08 Thao Nguyen, Lea Zillich, Metin Cetin, Alisha S. M. Hall, Jerome C. Foo, Lea Sirignano, Josef Frank, Tabea S. Send, Maria Gilles, Marcella Rietschel, Michael Deuschle, Stephanie H. Witt, Fabian Streit
The COVID-19 pandemic severely affected the lives of families and the well-being of both parents and their children. Various factors, including prenatal stress, dysregulated stress response systems...
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Examination of the role of adrenergic receptor stimulation in the sensitization of neuroinflammatory-based depressive-like behavior in isolated Guinea pig pups Stress (IF 2.3) Pub Date : 2023-08-06 Rachel R. Kessler, Patricia A. Schiml, Sean M. McGraw, Erin N. Tomlin, Mikayla J. Hoeferlin, Terrence Deak, Michael B. Hennessy
Abstract Early-life attachment disruption appears to sensitize neuroinflammatory signaling to increase later vulnerability for stress-related mental disorders, including depression. How stress initiates this process is unknown, but studies with adult rats and mice suggest sympathetic nervous system activation and/or cortisol elevations during the early stress are key. Guinea pig pups isolated from
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Burnout among high school students is linked to their telomere length and relatedness with peers Stress (IF 2.3) Pub Date : 2023-08-03 Frances Hoferichter, Armin Jentsch, Lou Maas, Geja Hageman
Abstract School burnout is a serious concern, as it impairs students’ health and academic success. According to the Conservation of Resources Theory, burnout results from the depletion of personal coping resources and can be counteracted by supportive social relationships. However, it is not yet clear how students’ relatedness with their peers is linked to their burnout. Next to students’ self-reported
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Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice Stress (IF 2.3) Pub Date : 2023-07-03 Yuan-Yuan Han, Jian-Wen Zhou, Zhi-Wei Guo, Zhuo-Qing Wu, Zai-Yong Zhang, De-xiang Liu, Cheng Long
Abstract The lysine 63 deubiquitinase cylindromatosis (CYLD) is expressed at high levels in the brain and is considered to be involved in anxious and depressive behavior, cognitive inflexibility, and autism disorders. Previous research was limited in some brain regions, including the hippocampus, striatum, and amygdala. To better understand whether CYLD plays a role in adaptation to stress and which
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The chronic stress risk phenotype mirrored in the human retina as a neurodegenerative condition Stress (IF 2.3) Pub Date : 2023-06-02 Leoné Malan, Roelof van Wyk, Roland von Känel, Tjalf Ziemssen, Walthard Vilser, Peter M. Nilsson, Martin Magnusson, Amra Jujic, Daniel W. Mak, Faans Steyn, Nico T. Malan
Abstract The brain is the key organ that orchestrates the stress response which translates to the retina. The retina is an extension of the brain and retinal symptoms in subjects with neurodegenerative diseases substantiated the eye as a window to the brain. The retina is used in this study to determine whether chronic stress reflects neurodegenerative signs indicative of neurodegenerative conditions
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The big picture: Mary Dallman, a role model Stress (IF 2.3) Pub Date : 2023-05-24 Marian Joëls
Abstract Mary Dallman has left a legacy in neuroendocrinology, not only as the scientist who elaborated on new concepts such as rapid corticosteroid feedback pathways, but also as a role model, particularly for women who followed in her footsteps. In this contribution, I compare (i) the remarkable journey she made toward her position as the first female faculty member ever at the physiology department
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Voluntary wheel running promotes resilience to the behavioral effects of unpredictable chronic mild stress in male and female mice Stress (IF 2.3) Pub Date : 2023-05-19 Elias Elias, Ariel Y. Zhang, Abigail G. White, Matthew J. Pyle, Melissa T. Manners
Abstract Besides significant benefits to physical health, exercise promotes mental health, reduces symptoms of mental illness, and enhances psychological development. Exercise can offset the impact of chronic stress, which is a major precursor to the development of mental disorders. The effects of exercise on chronic stress-induced behaviors are contradictory in preclinical studies, primarily due to
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From ligands to behavioral outcomes: understanding the role of mineralocorticoid receptors in brain function Stress (IF 2.3) Pub Date : 2023-05-08 Huanqing Yang, Sowmya Narayan, Mathias V. Schmidt
Abstract Stress is a normal response to situational pressures or demands. Exposure to stress activates the hypothalamic-pituitary-adrenal (HPA) axis and leads to the release of corticosteroids, which act in the brain via two distinct receptors: mineralocorticoid receptors (MR) and glucocorticoid receptors (GR). Persistent HPA axis overactivation or dysregulation can disrupt an individual’s homeostasis
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Testosterone and cortisol responses to acute and prolonged stress during officer training school Stress (IF 2.3) Pub Date : 2023-04-23 Regula Zueger, Hubert Annen, Ulrike Ehlert
Abstract Prolonged or severe stress has been found to inhibit the hypothalamic-pituitary-gonadal axis (HPG) and its testosterone release. In contrast, acute stress, including competition, social evaluation, or physical challenges, shows more inconsistent response patterns. This study examined changes in cortisol and testosterone across different types and durations of stress in the same individuals
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Pre-reproductive stress in adolescent female rats alters maternal care and DNA methylation patterns across generations Stress (IF 2.3) Pub Date : 2023-04-22 Hiba Zaidan, Agnieszka Wnuk, Idan M. Aderka, Malgorzata Kajta, Inna Gaisler-Salomon
Abstract Stress during development affects maternal behavior and offspring phenotypes. Stress in adolescence is particularly consequential on brain development and maturation, and is implicated in several psychiatric disorders. We previously showed that pre-reproductive stress (PRS) in female adolescent rats affects behavior and corticotropin releasing hormone receptor 1 (CRHR1) expression in first-
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Acute psychosocial stress weakens the sense of agency in healthy adults Stress (IF 2.3) Pub Date : 2023-04-12 Yayun Chu, Guanhua Huang, Yunyun Li, Qin Chen, Jiajia Liu, Ke Zhao, Xiaolan Fu
Abstract The sense of agency (SoA) refers to the feeling of being in control of one’s actions and the subsequent consequence of these actions. Emotional context seems to alter the strength of sense of agency. The present study explored the influence of acute psychosocial stress on the SoA by means of the Trier Social Stress Test (TSST). Self-assessment manikin (SAM) and objective physiological indicators
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Integrating the pattern of negative emotion processing and acute stress response with childhood stress among healthy young adults Stress (IF 2.3) Pub Date : 2023-04-03 Jianhui Wu, Yutong Liu, Liang Zhang, Naiyi Wang, Nils Kohn, Hongxia Duan
Abstract Childhood adversity might impair corticolimbic brain regions, which play a crucial role in emotion processing and the acute stress response. The dimensional model of childhood adversity proposed that deprivation and threat dimensions might associated with individuals’ development through different mechanisms. However, few studies have explored the relationship between different dimensions
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Subjective cognitive complaints and its associations to response inhibition and neural activation in patients with stress-related exhaustion disorder Stress (IF 2.3) Pub Date : 2023-03-20 Andreas Nelson, Hanna Malmberg Gavelin, Micael Andersson, Maria Josefsson, Therese Eskilsson, Lisbeth Slunga Järvholm, Anna Stigsdotter Neely, Carl-Johan Boraxbekk
Abstract Stress-related exhaustion is associated with cognitive deficits, measured subjectively using questionnaires targeting everyday slips and failures or more objectively as performance on cognitive tests. Yet, only weak associations between subjective and objective cognitive measures in this group has been presented, theorized to reflect recruitment of compensational resources during cognitive
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Gamma-amino butyric acid (GABA) supplementation alleviates dexamethasone treatment-induced oxidative stress and inflammation response in broiler chickens Stress (IF 2.3) Pub Date : 2023-03-12 Mokhtar Fathi, Shahryar Saeedyan, Majid Kaoosi
Abstract This experiment was conducted to investigate the effect of Gamma-amino butyric acid (GABA) on growth performance, serum and liver antioxidant status, inflammation response and hematological changes, in male broiler chickens under experimentally induced stress via in-feed dexamethasone (DEX). A total of 300 male chicks (Ross 308) on day 7 after hatching, were randomly selected into four groups
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Sleep restriction during opioid abstinence affects the hypothalamic-pituitary-adrenal (HPA) axis in male and female rats Stress (IF 2.3) Pub Date : 2023-03-12 Hershel Raff, Breanna L. Glaeser, Aniko Szabo, Christopher M. Olsen, Carol A. Everson
Abstract Hypothalamic-pituitary-adrenal (HPA) axis dynamics are disrupted by opioids and may be involved in substance abuse; this persists during withdrawal and abstinence and is associated with co-morbid sleep disruption leading to vulnerability to relapse. We hypothesized that chronic sleep restriction (SR) alters the HPA axis diurnal rhythm and the sexually dimorphic response to acute stressor during
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Increasing resolution in stress neurobiology: from single cells to complex group behaviors Stress (IF 2.3) Pub Date : 2023-03-09 Lucas Miranda, Joeri Bordes, Serena Gasperoni, Juan Pablo Lopez
Abstract Stress can have severe psychological and physiological consequences. Thus, inappropriate regulation of the stress response is linked to the etiology of mood and anxiety disorders. The generation and implementation of preclinical animal models represent valuable tools to explore and characterize the mechanisms underlying the pathophysiology of stress-related psychiatric disorders and the development
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Inverse association between stress induced cortisol elevations and negative emotional reactivity to stress in humans Stress (IF 2.3) Pub Date : 2023-02-11 Heather C. Abercrombie, Alexandra L. Barnes, Elizabeth C. Nord, Anna J. Finley, Estelle T. Higgins, Daniel W. Grupe, Melissa A. Rosenkranz, Richard J. Davidson, Stacey M. Schaefer
Abstract Greater cortisol reactivity to stress is often assumed to lead to heightened negative affective reactivity to stress. Conversely, a growing body of evidence demonstrates mood-protective effects of cortisol elevations in the context of acute stress. We administered a laboratory-based stressor, the Trier Social Stress Test (TSST), and measured cortisol and emotional reactivity in 68 adults (48
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Measuring stress: a review of the current cortisol and dehydroepiandrosterone (DHEA) measurement techniques and considerations for the future of mental health monitoring Stress (IF 2.3) Pub Date : 2023-01-10 Tashfia Ahmed, Meha Qassem, Panicos A. Kyriacou
Abstract Psychological stress and its inevitable trajectory toward mental health deteriorations such as clinical and major depression has become an unprecedented global burden. The diagnostic procedures involved in the characterization of mental illnesses commonly follow qualitative and subjective measures of stress, often leading to greater socioeconomic burdens due to misdiagnosis and poor understanding
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Acute stress and human spatial working memory strategy use Stress (IF 2.3) Pub Date : 2022-12-15 Robyn A. Husa, Tony W. Buchanan, Brenda A. Kirchhoff
Abstract Acute stress can impair human working memory. Little is known, however, about the effects of acute stress on working memory strategies. The goal of this research was to investigate the effects of acute stress on use of a systematic spatial working memory search strategy. Participants (28 females and 20 males per group) completed the Trier Social Stress Test (TSST) or control tasks. Use of
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Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice Stress (IF 2.3) Pub Date : 2022-12-15 Xueping Yao, Xiaoqun Qin, Hui Wang, Jiaoyun Zheng, Zhi Peng, Jie Wang, Horst Christian Weber, Rujiao Liu, Wenrui Zhang, Ji Zeng, Suhui Zuo, Hui Chen, Yang Xiang, Chi Liu, Huijun Liu, Lang Pan, Xiangping Qu
Abstract Bombesin receptor-activated protein (BRAP) and its homologous protein in mice, which is encoded by bc004004 gene, were expressed abundantly in brain tissues with unknown functions. We treated bc004004-/- mice with chronic unpredictable mild stress (CUMS) to test whether those mice were more vulnerable to stress-related disorders. The results of forced swimming test, sucrose preference test
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Identification of salivary microRNA profiles in male mouse model of chronic sleep disorder Stress (IF 2.3) Pub Date : 2022-12-15 Yuta Yoshida, Yuhei Yajima, Yuri Fujikura, Haotong Zhuang, Sayaka Higo-Yamamoto, Atsushi Toyoda, Katsutaka Oishi
Abstract Chronic sleep disorders (CSD) comprise a potential risk factor for metabolic and cardiovascular diseases, obesity and stroke. Thus, the identification of biomarkers for CSD is an important step in the early prevention of metabolic dysfunctions induced by sleep dysfunction. Diagnostic saliva samples can be easily and noninvasively collected. Thus, we aimed to identify whole microRNA (miRNA)
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PLC, PTH and NF-κB increased during orthodontic bone remodeling in chronic stress rats Stress (IF 2.3) Pub Date : 2022-11-25 Li Xiaotong, Yu Jiazhi, Li Xiaoguang, Zhao Gang
Abstract This study was designed to investigate the potential effects of chronic stress on periodontal bone remodeling and its mechanism during orthodontic tooth movement in rats. Forty-eight male SD rats aged 8 weeks were randomly divided into control group and chronic stress group. Chronic unpredictable mild stress model (CUMS) was established in the stress group, which was validated by behavioral
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Immune cell dynamics in response to an acute laboratory stressor: a within-person between-group analysis of the biological impact of early life adversity Stress (IF 2.3) Pub Date : 2022-11-21 Laura Etzel, Abner T. Apsley, Brooke C. Mattern, Waylon J. Hastings, Thomas Heller, Nilam Ram, Sue Rutherford Siegel, Idan Shalev
Abstract Early life adversity (ELA) is a risk factor for early onset morbidities and mortality, a relationship that may be driven in part by immune system dysregulation. One mechanism of dysregulation that has yet to be fully examined in the context of ELA is alterations to immune cell dynamics in response to acute stress. Using a within-person between-group experimental design, we investigated stress-induced
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Protective effects of nanocurcumin against stress-induced deterioration in the intestine Stress (IF 2.3) Pub Date : 2022-11-11 Azam Alinaghipour, Mahmoud Salami, Esmail Riahi, Ghorbangol Ashabi, Masoud Soheili, Fatemeh Nabavizadeh
Abstract The therapeutic activities of curcumin have long been investigated in some chronic and inflammatory diseases. This study was designed to investigate the protective effects of nanocurcumin on intestinal barrier function, apoptosis, and oxidative stress in rats exposed to traffic noise. Forty rats were divided into four groups: two traffic noise-exposed groups of animals that received either
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Interaction of chronic pain, obesity and time of day on cortisol in female human adolescents Stress (IF 2.3) Pub Date : 2022-11-04 Hershel Raff, Jonathan Phillips, Pippa Simpson, Steven J. Weisman, Keri R. Hainsworth
Abstract Adolescent obesity augments and impedes the treatment of chronic pain. This is associated with increased systemic inflammation and is more prominent in females. In addition, pain and obesity each independently affect the hypothalamic-pituitary-adrenal (HPA) axis. However, the interaction of pain and obesity on the HPA axis and the potential for sexual dimorphism in this phenomenon is not established
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Cortisol changes in healthy children and adolescents during the COVID-19 pandemic Stress (IF 2.3) Pub Date : 2022-09-27 Madison H. Fung, Brittany K. Taylor, Christine M. Embury, Rachel K. Spooner, Hallie J. Johnson, Madelyn P. Willett, Michaela R. Frenzel, Amy S. Badura-Brack, Stuart F. White, Tony W. Wilson
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has caused massive disruptions to daily life in the United States, closing schools and businesses and increasing physical and social isolation, leading to deteriorations in mental health and well-being in people of all ages. Many studies have linked chronic stress with long-term changes in cortisol secretion, which has been implicated in many
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Differences in acute stress responses depending on first or second language in a Hispanic-American sample Stress (IF 2.3) Pub Date : 2022-08-24 Felicitas Hauck, Lucía Romero Gibu, Silke Jansen, Nicolas Rohleder
Abstract Using a second language is a daily experience for many people today, among them many migrants. To determine whether speaking a second language induces a stronger cortisol or alpha-amylase (sAA) response than first language, we tested a Hispanic-American sample in two Trier Social Stress Test (TSST) conditions: First (Spanish) and second (German) language. Thirty-two participants (64.5% female)
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The impact of chronic stress on the PFC transcriptome: a bioinformatic meta-analysis of publicly available RNA-sequencing datasets Stress (IF 2.3) Pub Date : 2022-08-18 Anand Gururajan
Abstract The prefrontal cortex (PFC) is one of several brain structures that are sensitive to chronic stress exposure. There have been several studies which have examined the effects on chronic stress, using various protocols such as chronic unpredictable stress and chronic social defeat stress, on the PFC transcriptome. In this report, a bioinformatic meta-analysis of publicly available RNA sequencing
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Juvenile exposure to doxorubicin alters the cardiovascular response to adult-onset psychosocial stress in mice Stress (IF 2.3) Pub Date : 2022-08-09 Marianne K. O. Grant, Maria Razzoli, Ibrahim Y. Abdelgawad, Rachel Mansk, Davis Seelig, Alessandro Bartolomucci, Beshay N. Zordoky
Abstract Childhood cancer survivors have a high risk for premature cardiovascular diseases, mainly due to cardiotoxic cancer treatments such as doxorubicin (DOX). Psychosocial stress is a significant cardiovascular risk factor and an enormous burden in childhood cancer survivors. Although observational studies suggest that psychosocial stress is associated with cardiovascular complications in cancer
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Variation in trauma-related behavioral effects using a preclinical rat model of three predator exposure stress Stress (IF 2.3) Pub Date : 2022-08-03 Emily Scott, Matthew May, Gabriella Silva, Rachel Taylor, Nicole Fenlon, Emily Lowery-Gionta, Liana Matson
Abstract The underlying mechanisms of trauma-related disorders are challenging to discover and the disorders are difficult to treat, in part due to the complex and varied expressions of response to traumatic stress. These challenges will be easier to overcome as more is understood about the variability in response to trauma. Incorporating assessment of variability into animal models of traumatic stress
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Association of stress-related neural activity and baseline interleukin-6 plasma levels in healthy adults Stress (IF 2.3) Pub Date : 2022-07-19 Johanna F. Voges, Laura Müller-Pinzler, Miriam Neis, Finn Luebber, Tanja Lange, Jennifer E. Hundt, Meike Kasten, Ulrike M. Krämer, Sören Krach, Lena Rademacher
Abstract Several studies suggest a link between acute changes in inflammatory parameters due to an endotoxin or (psychological) stressor and the brain’s stress response. The extent to which basal circulating levels of inflammatory markers are associated with the brain’s stress response has been hardly investigated so far. In the present study, baseline plasma levels of the cytokine interleukin (IL)-6
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Caregiving stress and burden associated with cardiometabolic risk in family caregivers of individuals with cancer Stress (IF 2.3) Pub Date : 2022-06-21 Lena J. Lee, Youngmee Kim, Robert Shamburek, Alyson Ross, Li Yang, Margaret F. Bevans
Abstract Chronic stress is a well-established risk factor for cardiometabolic disease. Caregiving for individuals with cancer is perceived as a chronic stressor yet research on the risk for cardiometabolic disease in this population, opposed to the elderly and those with Alzheimer’s disease, is limited. Additionally, few studies have explored the early physiological changes that occur in family caregivers
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Effects of psychosocial stress on prosociality: the moderating role of current life stress and thought control Stress (IF 2.3) Pub Date : 2022-06-17 Lisa Hensel, Nicolas Rohleder, Cornelia Niessen
Abstract To date, only a few studies have examined whether and when stressed individuals are still prosocially motivated and willing to help others, which is in contrast to the relevance and importance that helping others has for our society. The present study investigates the impact of affective and biopsychological acute stress responses on prosociality (prosocial motivation, helping behavior) under
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The effect of COVID-19 lockdown on mental health, gut microbiota composition and serum cortisol levels Stress (IF 2.3) Pub Date : 2022-06-17 Karin Šik Novak, Nives Bogataj Jontez, Saša Kenig, Matjaž Hladnik, Alenka Baruca Arbeiter, Dunja Bandelj, Maša Černelič Bizjak, Ana Petelin, Nina Mohorko, Zala Jenko Pražnikar
Abstract The aim of this study was to assess changes in mental health, gut microbiota composition, and stress marker serum cortisol due to COVID-19 lockdown in asymptomatic individuals. Healthy adults participated in anthropometric measurements, blood and stool sample collection pre-lockdown and post-lockdown (n = 38, 63.2% females), lifestyle and psychological questionnaires were included in pre-lockdown
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Stress adaptation in rats associate with reduced expression of cerebrovascular Kv7.4 channels and biphasic neurovascular responses Stress (IF 2.3) Pub Date : 2022-06-06 Christian Staehr, Elena V. Bouzinova, Ove Wiborg, Vladimir V. Matchkov
Abstract Neurovascular coupling ensures rapid and precise delivery of O2 and nutrients to active brain regions. Chronic stress is known to disturb neurovascular signaling with grave effects on brain integrity. We hypothesized that stress-induced neurovascular disturbances depend on stress susceptibility. Wistar male rats were exposed to 8 weeks of chronic mild stress. Stressed rats with anhedonia-like