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YTHDF1-mediated sphingosine kinase 2 upregulation alleviates bupivacaine-induced neurotoxicity via the PI3K/AKT axis Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-03-15 Ru Yuan, Chunxia Wu
BackgroundBupivacaine (BUP), a long-acting local anesthetic, has been widely used in analgesia and anesthesia. However, evidence strongly suggests that excessive application of BUP may lead to neurotoxicity in neurons. Sphingosine kinase 2 (SPHK2) has been reported to exert neuroprotective effects. In this study, we intended to investigate the potential role and mechanism of SPHK2 in BUP-induced neurotoxicity
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Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance memory performance, amyloid precursor proteins, and TNF-α levels in the prefrontal cortex of rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-03-13 Salva Afshari, Mehdi Sarailoo, Vahid Asghariazar, Elham Safarzadeh, Masoomeh Dadkhah
IntroductionOrganophosphate pesticides (Ops) like diazinon (DZN) have well-known neurotoxic effects and low-level chronic exposure has been linked to detrimental neurobehavioral impairments and memory deficits. However, it’s not entirely clear how DZN-induced biological changes, particularly in the prefrontal cortex (PFC) contribute to these effects. The purpose of this study is to investigate the
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Hepatic P53 upregulation and the genotoxic potential of acesulfame-K treatment in rats with a special emphasis on in vitro lymphocyte and macrophage activity testing Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-02-29 Faten F. Mohammed, Eman G. Abdelrazik, Abeer Anwar, Sherein S. Abdelgayed
Acesulfame-k (Ace-k) is a widely used artificial sweetener in various products, and long-term cumulative and multisource exposure is possible despite inadequate toxicological data confirming its safety. Ninety male rats were divided into two main groups according to their body weight into immature and mature rats. Each group was subdivided into 3 subgroups: control untreated, 30 and 90 mg/kg b. w of
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Epidemiology studies on effects of lithium salts in pregnancy are confounded by the inability to control for other potentially teratogenic factors Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-02-23 Carr J. Smith, Victoria M. Payne
IntroductionIn bipolar women who took lithium during pregnancy, several epidemiology studies have reported small increases in a rare fetal cardiac defect termed Ebstein’s anomaly.MethodsBehavioral, environmental, and lifestyle-associated risk factors associated with bipolar disorder and health insurance status were determined from an Internet search. The search was conducted from October 1, 2023, through
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Effects of doxorubicin on autophagy in fibroblasts Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-02-07 Anna Shuey, Conner Patricelli, Julia T Oxford, Xinzhu Pu
Objectives: Doxorubicin (DOX) is a highly effective chemotherapeutic used to treat many adult and pediatric cancers, such as solid tumors, leukemia, lymphomas and breast cancer. It can also cause injuries to multiple organs, including the heart, liver, and brain or kidney, although cardiotoxicity is the most prominent side effect of DOX. In this study, we examined the potential effects of DOX on autophagy
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Estimated mercury vapor exposure from amalgams among American pregnant women Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-02-06 David A Geier, Mark R Geier
This study examined the impact of mercury (Hg) vapor exposure from amalgams among all American pregnant women. Amalgam-Hg vapor exposure among 1,665,890 weighted-pregnant women ( n = 37) was examined in the 2015-2020 National Health and Nutrition Examination Survey (NHANES). Correlation coefficients between amalgam surfaces and daily micrograms (µg) of urinary Hg excretion and daily µg of Hg vapor
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Widely targeted quantitative lipidomics reveal lipid remodeling in adipose tissue after long term of the combined exposure to bisphenol A and fructose Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-02-06 Yonghong Tang, Guifang Ou, Ouyan Rang, Xu Liu, Xiaocheng Liu, Xinru Qin, Guojuan Li, Qing Yang, Mu Wang
Adipose tissue is the main organ that stores lipids and it plays important roles in metabolic balance in the body. We recently reported in Human and Experimental Toxicology that the combined exposure to BPA and fructose may interfere with energy metabolism of adipose tissue. However, it is still unclear whether the combined exposure to BPA and fructose has the possibility to induce lipid remodeling
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Ginsenoside Rg5 induces NSCLC cell apoptosis and autophagy through PI3K/Akt/mTOR signaling pathway Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-01-30 Caidie Zhang, Yan Jin
ObjectiveGinsenoside Rg5 (Rg5) is a minor ginsenoside of ginseng and has a strong anti-tumor potential. This study focused on deciphering the function of Rg5 in non-small cell lung cancer (NSCLC) and investigating its related mechanism.MethodsAfter treating human NSCLC cell lines (H1650 and A549) and bronchial epithelial cells (BEAS-2B) with increasing concentration of Rg5, cell viability was examined
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Liver and ovarian toxicities boosted by bisphenol and gamma radiation in female albino rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-01-24 Asmaa A Hassan, Sherein S Abdelgayed, Somaya Z Mansour
Bisphenol A (BPA), a carbon-based synthetic polymer compound, was newly classified as an environmental toxicant and an endocrine-disrupting chemical leading to abnormalities in cell proliferation, apoptosis, or migration that contributes to cancer development and progression. This study aims to evaluate the effect of the elevation of γ- radiation dose and BPA on the liver and ovaries of female rats
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Evaluation of antioxidant properties and cytotoxicity of brown algae (nizamuddinia zanardinii) in uterine (hela) and pancreatic cancer cell lines (paca-2) Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-01-19 Milad Amerifar, Hesamoddin Arabnozari, Mohammad Shokrzadeh, Emran Habibi
IntroductionPancreatic cancer and cervical cancer are among the most common cancers. Brown algae have anti-inflammatory, anti-cancer, anti-fungal, antioxidant, and immune-boosting properties. This study investigated the antioxidant properties and the effect of brown algae extract on pancreatic and uterine cancer cells.Materials and methodsIn this study, Cervical (Hela) and pancreas (Paca-2) cancer
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The effect of melatonin on capecitabine-induced hepatic and renal toxicity in rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-01-05 Ali Tavakoli Pirzaman, Razieh Mansoori, Seyed Mohammad Hosseini, Ali Abolhosseini, Sahar Khosravi, Ali Akbar Moghadamnia, Sohrab Kazemi
BackgroundCapecitabine (CAPE), an antimetabolite chemotherapy, can induce hepatic and renal toxicity. Melatonin (MEL), a neurohormone, possesses antioxidant, anti-apoptotic and anti-inflammatory effects. This study investigated the impact of MEL on capecitabine-induced hepatic and renal toxicity.Methods and materialsTwenty-five male Wistar rats were categorized into five groups for the study. The groups
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Evaluation of Cd-induced cytotoxicity in primary human keratinocytes Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-01-04 Daniil Romashin, Viktoriia Arzumanian, Ekaterina Poverennaya, Alexandra Varshaver, Nataliya Luzgina, Alexander Rusanov
An increasing number of studies have investigated the effects of Cd on human health. Cd-induced dermatotoxicity is an important field of research, but numerous studies have focused on the effects of Cd on the human skin. Moreover, most studies have been performed using HaCaT cells but not primary keratinocytes. In this study, we provide the results describing the cytotoxic effects of Cd exposure on
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Gpnmb silencing protects against hyperoxia-induced acute lung injury by inhibition of mitochondrial-mediated apoptosis Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-01-03 Xiaoqin Wang, Song Qin, Yingcong Ren, Banghai Feng, Junya Liu, Kun Yu, Hong Yu, Zhenliang Liao, Hong Mei, Mei Tan
Background: Hyperoxia-induced acute lung injury (HALI) is a complication to ventilation in patients with respiratory failure, which can lead to acute inflammatory lung injury and chronic lung disease. The aim of this study was to integrate bioinformatics analysis to identify key genes associated with HALI and validate their role in H2O2-induced cell injury model.Methods: Integrated bioinformatics analysis
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Potential induction of hyperkeratosis in rats’ cervi by gentamicin via induction of oxidative stress, inflammation and apoptosis Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2024-01-03 Walaa Yehia Abdelzaher, Mina Ezzat Attya, Mohamed Ahmed Zeen El-Din, Alaa Gamal El Satae, Hatem A Mohamed, Remon R Rofaeil
The present study aimed to identify the possible effect of gentamicin (GEN) in Rats’ Cervi. Estradiol Valerate (EV) was used to induce cervical hyperkeratosis. GEN was administered in absence of EV. Serum and cervical GEN concentration were determined. Levels of malondialdehyde (MDA), total nitrites/nitrate (NOx), reduced glutathione (GSH), tumor necrosis factor-α (TNF-α), sirtuin type 1 (Sirt1) and
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Microsomal glutathione S-transferase 1 targets the autophagy signaling pathway to suppress ferroptosis in gastric carcinoma cells Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-05-10 Z Peng, N Peng
ObjectiveFerroptosis is a newly discovered form of programmed cell death; however, the specific mechanisms that regulate ferroptosis have yet to be fully elucidated in gastric carcinoma. In this st...
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Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-05-08 Zheyu Zhang, Ruozheng Pi, Yuheng Jiang, Mashaal Ahmad, Heng Luo, Jieya Luo, Jie Yang, Baofei Sun
Arsenic is a prevalent environmental pollutant that targets the nervous system of living beings. Recent studies indicated that microglial injury could contribute to neuroinflammation and is associa...
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Neurologic disease produced by Rathayibacter toxicus-derived corynetoxins Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-05-03 John Finnie
Corynetoxins, members of the tunicamycin group of antibiotics, are produced by the bacterium, Rathayibacter toxicus. They cause a severe neurologic disorder in domestic livestock, are hepatotoxins,...
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Establishment of an animal model of sciatic nerve injury induced by local anesthetics Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-26 Qi E, Yunlin Wu, Xiaoxia Liang, Meixin Chen, Jiayi Peng, Ziyin Zhou, Xianjie Wen
Peripheral neurotoxicity injury caused by local anesthetics is a common complication of clinical anesthesia. The study of its mechanism is helpful to prevent and treat the neurotoxic injury of loca...
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Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic and histological profile in male albino rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-25 Ali Hamza, Muhammad Umar Ijaz, Haseeb Anwar
The current research was performed to evaluate the ameliorative effects of Rhamnetin (RHM) on polystyrene microplastics (PS-MPs)-instigated testicular dysfunction in male albino rats. 48 albino rat...
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Discovery of the mechanism of n-propylparaben-promoting the proliferation of human breast adenocarcinoma cells by activating human estrogen receptors via metabolomics analysis Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-25 Yunxia Chen, Chan Zhao, Jun Zheng, Ning Su, Hainan Ji
BackgroundN-propylparaben (PP), a type of paraben, is commonly used as a preservative or antibacterial agent in daily chemicals, medicine, food, cosmetics, feed, and various industrial preservative...
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Preclinical Evaluation of interferon-gamma primed human Wharton’s jelly-derived mesenchymal stem cells Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-24 Sang-Jin Park, Dae Seong Kim, Myeongjin Choi, Kang-Hyun Han, Ji-Seok Han, Keon Hee Yoo, Kyoung-Sik Moon
The potential of human mesenchymal stem cells (MSCs) for cell therapy has been investigated in numerous immune-mediated conditions; MSCs are considered one of the most promising cellular therapeuti...
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Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-19 Jiaying Pan, Jie Zhu, Liang Li, Tao Zhang, Zhenyu Xu
BackgroundSalidroside (SAL) is an anti-inflammatory, antioxidant, anticancer, neuroprotective, and renal protective active ingredient extracted from the Chinese herb. Rhodiola Rosea. However, the r...
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Tricin attenuates diabetic retinopathy by inhibiting oxidative stress and angiogenesis through regulating Sestrin2/Nrf2 signaling Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-19 Xueli Yang, Dalei Li
To explore the potential function of tricin in diabetic retinopathy (DR) and investigate whether Sestrin2 is closely involved in DR. A single intraperitoneal injection of streptozotocin-induced dia...
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Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-18 Fatemeh Ghafari, Zohre Sadeghian, Akram Oftadeh Harsin, Sodabe Khodabandelo, Akram Ranjbar
BackgroundZearalenone (ZEA) is a mycotoxin produced by fungi and induces cytotoxicity by the generation of reactive oxygen species. The aim of this study was to evaluate and compare the nephroprote...
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Relationship between clock gene expression and CYP2C19 and CYP3A4 with benzodiazepines Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-18 Naoto Tani, Tomoya Ikeda, Takaki Ishikawa
The present study aimed to clarify the expressions and roles of clock genes involved in drug metabolism in patients taking benzodiazepines (BZDs), as well as the drug metabolism regulators controll...
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Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-12 Yanli Song, Dongjie He, Shaoqi Shi, Tianwei Cui, Hui Zhang, Xianmin Zhao, Tingting Ni, Huidongzi Xiao, Aiwu Wei
BackgroundWomen with antiphospholipid syndrome (APS) or antiphospholipid antibodies (aPLs) are at high risk for obstetric complications, including recurrent pregnancy loss (RPL). However, effective...
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Beneficial effects of sennoside B on pentylenetetrazole-induced seizures in rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-04-05 Hüseyin Sahin, Oytun Erbaş
BackgroundEpilepsy is a common disorder affecting approximately 50 million people worldwide. Oxidative stress is known to play an important role in the pathophysiology of diseases, including epilep...
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Sitagliptin attenuates neuronal apoptosis via inhibiting the endoplasmic reticulum stress after acute spinal cord injury Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-28 Chengxuan Tang, Tianzhen Xu, Minghai Dai, Xiqiang Zhong, Guangjie Shen, Liangle Liu
Regulation of endoplasmic reticulum stress (ER) stress-induced apoptosis and nerve regeneration is a hopeful way for acute spinal cord injury (SCI). Sitagliptin (Sita) is one of dipeptidyl peptidas...
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Treatment with paraquat affects the expression of ferroptosis-related genes Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-24 Xiaogang Ge, Qiqi Cai, Sheng Zhang, Xianlong Wu, Pan Ying, Jingjing Ke, Zhihui Yang
ObjectiveWe aimed to explore the mechanisms underlying paraquat (PQ)-induced damage using cell lines (NCTC1469, TC-1, TCMK-1) and bioinformatic analysis of the GSE153959 dataset. Assessment of chan...
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Syringaresinol inhibits cardiorenal fibrosis through HSP90 in a cardiorenal syndrome type 2 Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-24 Jianjie Wang, Jianqin Zou, Cheng Zhao, Han Yu, Jiajia Teng, Lei Dong
BackgroundSyringaresinol processes anti-inflammatory and antioxidative activity. However, the effects of syringaresinol on cardiorenal fibrosis caused by cardiorenal syndrome type 2 (CRS2) are uncl...
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Intraperitoneal pretreatment of ellagic acid and chrysin alleviate ifosfamide-induced neurotoxicity, but betanin induces death in male wistar rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-23 Ahmad Salimi, Mohammad Shabani, Hossein Mohammadi, Vahid Sudi
BackgroundIfosfamide (IFO) is a widely used antineoplastic drug with broad-spectrum efficacy against various types of cancer. However, different toxicities associated with IFO has limited its use. ...
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Genistein attenuates renal ischemia-reperfusion injury via ADORA2A pathway Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-18 HY He, HZ Shan, SQ Li, RG Diao
BackgroundStudies have shown oxidative stress and apoptosis are the main pathogenic mechanisms of renal ischemia/reperfusion (IR) injury (IRI). Genistein, a polyphenolic non-steroidal compound, has...
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Protective effects of butylated hydroxytoluene on the initiation of N-nitrosodiethylamine-induced hepatocellular carcinoma in albino rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-21 Sally A Fahim, Samar Ibrahim, Samer A Tadros, Osama A Badary
Diethylnitrosamine (DEN), a hepatocarcinogen, is found in a variety of smoked and fried foods and was reported to be hepatotoxic in mice. Butylated hydroxytoluene (BHT) is a potent antioxidant used...
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Azilsartan suppresses the antiapoptotic biomarker and pro-inflammatory cytokines in rat model of cisplatin-induced retinal and optic nerve toxicity Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-17 Noor Majid Raheem, Naza Mohammed Ali Mahmood
BackgroundThe local renin-angiotensin system has been discovered in the eyes; thus, this study evaluates the Azilsartan effect in the retina and optic nerve toxicity induced by Cisplatin in vivo.Me...
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Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to drive ferroptosis in bladder cancer cells Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-11 Hongyan Zhu, Qitian Chen, Yang Zhang, Lingling Zhao
ObjectiveThe ability of glutathione S-transferase zeta 1 (GSTZ1) to modulate homeostasis of cellular redox and induce ferroptosis was explored in bladder cancer cells, and the involvement of the hi...
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A review of challenges and prospects of 3D cell-based culture models used for studying drug induced liver injury during early phases of drug development Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-06 John K Chipangura, Yonela Ntamo, Bert Mohr, Nireshni Chellan
Drug-induced liver injury (DILI) is the leading cause of compound attrition during drug development. Over the years, a battery of in-vitro cell culture toxicity tests is being conducted to evaluate...
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Genotoxicity of oxidative hair dye precursors: A systematic review Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-06 Željka Babić, Sarah Hallmann, Martin S Havmose, Jeanne D Johansen, Swen M John, Cara Symanzik, Wolfgang Uter, Patricia Weinert, Henk F van der Molen, Sanja Kezic, Jelena Macan, Rajka Turk
This systematic review, conducted according to the PRISMA guidelines, focuses on genotoxicity of oxidative hair dye precursors. The search for original papers published from 2000 to 2021 was perfor...
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Prenatal cyanuric acid exposure induced spatial learning impairments associated with alteration of acetylcholine-mediated neural information flow at the hippocampal CA3-CA1 synapses of male rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-03-08 Wei Sun, Xuanyin Zhao, Yiwen Wan, Yang Yang, Xiaoliang Li, Xiao Chen, Yazi Mei, Lei An
Cyanuric acid (CA) is reported to induce nephrotoxicity but its toxic effect is not fully known. Prenatal CA exposure causes neurodevelopmental deficits and abnormal behavior in spatial learning ab...
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Sevoflurane Postconditioning Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting SP1/ACSL4-Mediated Ferroptosis Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-26 Ning Lyu, Xiaoyun Li
Sevoflurane is the most commonly used anesthetic in clinical practice and exerts a protective effect on cerebral ischemia-reperfusion (I/R) injury. This study aims to elucidate the molecular mechan...
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MAPK-interacting kinases inhibition by eFT508 overcomes chemoresistance in preclinical model of osteosarcoma Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-25 Bin Huang, Peicheng Jin, Kaijun Yi, Junhu Duan
The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for many cancers with little known in osteosarcoma. This study evaluated the efficacy of eFT5...
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Signature of miR-21 and MEG-2 and their correlation with TGF-β signaling in breast cancer Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-24 EM Desouky, AK Khaliefa, WG Hozayen, SM Shaaban, NA Hasona
Breast cancer is highly prevalent and considered the main challenge to public health among females in Egypt as in other countries. MicroRNA-21 (miR-21) and MEG-2 are noncoding RNA attributed to the...
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Kaempferol inhibits airway inflammation induced by allergic asthma through NOX4-Mediated autophagy Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-21 Jianfeng Xu, Zhenyu Yu, Wei Li
BackgroundKaempferol has important medicinal value in the treatment of asthma. However, its mechanism of action has not been fully understood and needs to be explored and studied.MethodsA binding a...
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Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-14 Xiaoming Li, Yunhui Li, Peilong Lian, Qigang lv, Fangfeng Liu
Ferroptosis is potential to relieve drug resistance in hepatocellular carcinoma (HCC). Glutathione peroxidase 4 (GPX4) is a critical modulator of ferroptosis. This study discussed the mechanism of ...
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Serum and glucocorticoid inducible kinase 1 modulates mitochondrial dysfunction and oxidative stress in doxorubicin-induced cardiomyocytes by regulating Hippo pathway via Neural precursor cell-expressed developmentally down-regulated 4 type 2 Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-13 Zongyi Zou, Tingting Zhao, Zhu Zeng, Yuan An
Doxorubicin (Dox) was reported to cause mitochondrial dysfunction and oxidative stress in cardiomyocytes, leading to cardiomyocyte apoptosis and ultimately heart failure. Serum and glucocorticoid i...
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Albiflorin ameliorates mesangial proliferative glomerulonephritis by PI3K/AKT/NF-κB pathway Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-13 Haiyan Yu, Yu Wang, Zida He, Ruixue Chen, Yingni Dai, Yingqian Tang, Ye Chen
Background: The most common type of glomerulonephritis in China is mesangial proliferative glomerulonephritis (MPGN) featured with mesangial cell overproliferation and inflammation, as well as fibr...
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CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-04 Xingzhuo Guan, Tingzhu Lan, Yuanshi Wang, Yan Cui, Jinyu Duan, Hongjun Xu
BackgroundA growing number of studies have focused on the regulatory role of circular RNAs (circRNAs) in a variety of cancers. The purpose of this study was to investigate the effect of circRNA Ker...
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Irigenin attenuates lipopolysaccharide-induced acute lung injury by inactivating the mitogen-activated protein kinase (MAPK) signaling pathway Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-04 Dan Liu, Qing Wang, Wen Yuan, Qiang Wang
Acute lung injury (ALI) is a serious pulmonary inflammation disease with high mortality. Irigenin, an isoflavone from rhizomes of the Belamcanda chinensis, has been reported to exert anti-inflammat...
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Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-02-04 Qingjiao Zeng, Xiaolin Ji, Xueshen Li, Yanxun Tian
BackgroundNasopharyngeal carcinoma (NPC) is cancer with high mortality and poor prognosis. Circular RNAs (circRNAs) have been identified in a wide variety of cancers. But the functional mechanism o...
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Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced proliferation inhibition in ovarian granulosa cells via suppressing NLRP3/caspase1-mediated pyroptosis Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-17 Hongxia Xu, Xiumin Bao, Junya Yang, Hanxin Kong, Yan Li, Zhiwei Sun
BackgroundWe investigated the level of Cysteine-rich 61 (CYR61) in premature ovarian failure as well as its regulatory molecular mechanism in this study.Methods and ResultsCyclophosphamide (CTX) wa...
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MiR-155-5p-SOCS1/JAK1/STAT1 participates in hepatic lymphangiogenesis in liver fibrosis and cirrhosis by regulating M1 macrophage polarization Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-18 Jian Bi, Jia Liu, Xiuli Chen, Na Shi, Hao Wu, Haiying Tang, Jingwei Mao
BackgroundThe role and underlying mechanism of liver macrophages and their derived miR-155-5p in hepatic lymphangiogenesis in liver fibrosis remain unclear. Here, we investigated the mechanism by w...
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The IL-6/HO-1/STAT3 signaling pathway is implicated in the amelioration of acetaminophen-induced hepatic toxicity: A neonatal rat model Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-10 Remon Roshdy Rofaeil, Nermeen N Welson, Michael A Fawzy, Amira F Ahmed, Medhat Atta, Mohamed Ahmed Bahaa El-deen, Walaa Yehia Abdelzaher
The widespread use of acetaminophen (APAP) in children as an over-the-counter treatment can cause acute liver failure through accidental overdose or ingestion. Therefore, the current research sough...
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Mitochondrial ROS induced by ML385, an Nrf2 inhibitor aggravates the ferroptosis induced by RSL3 in human lung epithelial BEAS-2B cells Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-10 Indra Putra Taufani, Jiro Hasegawa Situmorang, Rifki Febriansah, Sri Tasminatun, Sunarno Sunarno, Liang-Yo Yang, Yi-Ting Chiang, Chih-Yang Huang
Ferroptosis is a new type of cell death marked by iron and lipid ROS accumulation. GPX4 is one of the glutathione peroxidases known to regulate ferroptosis tightly. On the other hand, Nrf2 also pla...
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Wasp-stung rat model translationally expresses the coagulopathy manifestations of human wasp patients Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-09 Dong Lai, Yan Tian, Chang-Fu Ji, Yuan Zang, Yaw-Syan Fu, Ching-Feng Weng
Two over 80 wasp stings male victims appeared severe abnormal coagulation were consecutively examined by thromboelastography (TEG) guided with heparinase during hospitalization. However, the cause ...
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Follow-up of patients with a 5-year survival after paraquat poisoning using computed tomography images and spirometry Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-09 Lu Fan, Xuejie Wang, Tianyi Lv, Fei Xue, Benhe Wu, Aiwen Ma, Mingfeng Lu
ObjectivesThe study aimed to examine long-term survival of patients with acute paraquat poisoning using computed tomography (CT) images and spirometry.MethodsA total of 36 patients with long-term s...
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Hyperglycemia-induced endothelial exosomes trigger trophoblast dysregulation and abnormal placentation through PUM2-mediated repression of SOX2 Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-06 Aibing Zhu, Suwan Qi, Wenjuan Li, Dashu Chen, Xiaomin Zheng, Jianjuan Xu, Yaling Feng
BackgroundHyperglycemia is closely related to adverse pregnancy outcomes including pre-eclampsia (PE), a life-threatening complication with a substantial morbidity and mortality. However, the patho...
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Kaempferol ameliorates palmitate-induced lipid accumulation in HepG2 cells through activation of the Nrf2 signaling pathway Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-06 Li Zhao, Liping Yang, Khalidamir Ahmad
ObjectivesKaempferol (KMF), has beneficial effects against hepatic lipid accumulation. In this study, we aimed to investigate molecular mechanism underlying the protective effect of KMF on lipid ac...
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MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-06 Wei Zhang, Qiu Zhang, Qianbo Cui, Yu Xu
BackgroundMicroRNA-3612 (miR-3612) is considered a tumor suppressor in different cancers. Nonetheless, its function in nasopharyngeal carcinoma (NPC) has yet to be uncovered.MethodsNPC cells and ti...
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Thymol co-administration abrogates hexachlorobenzene-induced reproductive toxicities in male rats Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-06 Abiola S Tijani, Ebenezer O Farombi, David O Olori
This present study was designed to investigate ameliorating potential of thymol (THY) on hexachlorobenzene (HBC)-induced epididymal and testicular toxicities in adult male rats. Forty adult male ra...
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Emodin protects against apoptosis and inflammation by regulating reactive oxygen species-mediated NF-κB signaling in interleukin‐1β-stimulated human nucleus pulposus cells Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-04 Xiaojuan Zhu, Shuqin Guo, Mingyuan Zhang, Xiaoliang Bai
Intervertebral disc degeneration (IDD) is a complex degradative disorder associated with inflammation. Emodin, an anthraquinone derivative, possesses strong anti-inflammatory activity. This study f...
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The transcript NR 134251.1 of lncRNA APTR with an opposite function to all transcripts inhibits proliferation and induces apoptosis by regulating proliferation and apoptosis-related genes Hum. Exp. Toxicol. (IF 2.8) Pub Date : 2023-01-03 Jinyi Yu, Shuting Li, Simin Shen, Qian Zhou, Jinyao Yin, Ruihuan Zhao, Jingwen Tan, Chenglan Jiang, Yuefeng He
Arsenic (As) exposure has been a global public health concern for hundreds of millions worldwide. LncRNA APTR (Alu-mediated p21 transcriptional regulator) plays an essential role in tumor growth an...