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Recommendations for the Cleaning of Endocavity Ultrasound Transducers Between Patients Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-14 Susan Campbell Westerway, Jocelyne M. Basseal, Jacques Abramowicz, Carmel Moran, WFUMB Safety Committee
The COVID-19 pandemic highlighted the importance of infection prevention and control measures for all medical procedures, including ultrasound examinations. As the use of ultrasound increases across more medical modalities, including point-of-care ultrasound, so does the risk of possible transmission from equipment to patients and patients to patients. This is particularly relevant for endocavity transducers
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Automatic Detection and Tracking of Anatomical Landmarks in Transesophageal Echocardiography for Quantification of Left Ventricular Function Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-13 Anders Austlid Taskén, Jinyang Yu, Erik Andreas Rye Berg, Bjørnar Grenne, Espen Holte, Håvard Dalen, Stian Stølen, Frank Lindseth, Svend Aakhus, Gabriel Kiss
Evaluation of left ventricular (LV) function in critical care patients is useful for guidance of therapy and early detection of LV dysfunction, but the tools currently available are too time-consuming. To resolve this issue, we previously proposed a method for the continuous and automatic quantification of global LV function in critical care patients based on the detection and tracking of anatomical
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Cardiac 2-D Shear Wave Imaging Using a New Dedicated Clinical Ultrasound System: A Phantom Study Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-12 Eric Saloux, Morgane Le Garrec, Nina Menet, Ludovic Dillon, Christophe Simard, Christophe Fraschini, Alain Manrique
The purpose of this study was to assess cardiac shear wave imaging implemented in a new MACH 30 ultrasound machine (SuperSonic Imaging, Aix-en-Provence, France) and interfaced with a linear probe and a phased array probe, in comparison with a previously validated Aixplorer system connected to a linear probe (SuperSonic Imaging) using Elasticity QA phantoms (Models 039 and 049, CIRS Inc., Norfolk, VA
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In Vivo Validation of an In Situ Calibration Bead as a Reference for Backscatter Coefficient Calculation Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-12 Yuning Zhao, Gregory J. Czarnota, Trevor H. Park, Rita J. Miller, Michael L. Oelze
The study described here was aimed at assessing the capability of quantitative ultrasound (QUS) based on the backscatter coefficient (BSC) for classifying disease states, such as breast cancer response to neoadjuvant chemotherapy and quantification of fatty liver disease. We evaluated the effectiveness of an titanium (Ti) bead as a reference target in calibrating the system and mitigating attenuation
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Patient-Specific Vascular Flow Phantom for MRI- and Doppler Ultrasound Imaging Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-11 Sadaf Soloukey, Bastian Generowicz, Esther Warnert, Geert Springeling, Joost Schouten, Chris De Zeeuw, Clemens Dirven, Arnaud Vincent, Pieter Kruizinga
Intraoperative Doppler ultrasound imaging of human brain vasculature is an emerging neuro-imaging modality that offers vascular brain mapping with unprecedented spatiotemporal resolution. At present, however, access to the human brain using Doppler Ultrasound is only possible in this intraoperative context, posing a significant challenge for validation of imaging techniques. This challenge necessitates
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Automating the Human Action of First-Trimester Biometry Measurement from Real-World Freehand Ultrasound Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-11 Robail Yasrab, He Zhao, Zeyu Fu, Lior Drukker, Aris T. Papageorghiou, J. Alison Noble
Automated medical image analysis solutions should closely mimic complete human actions to be useful in clinical practice. However, more often an automated image analysis solution represents only part of a human task, which restricts its practical utility. In the case of ultrasound-based fetal biometry, an automated solution should ideally recognize key fetal structures in freehand video guidance, select
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Automated Spontaneous Echo Contrast Detection Using a Multisequence Attention Convolutional Neural Network Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-08 Ouwen Huang, Zewei Shi, Naveen Garg, Corey Jensen, Mark L. Palmeri
Spontaneous echo contrast (SEC) is a vascular ultrasound finding associated with increased thromboembolism risk. However, identification requires expert determination and clinician time to report. We developed a deep learning model that can automatically identify SEC. Our model can be applied retrospectively without deviating from routine clinical practice. The retrospective nature of our model means
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Use of Real-Time Remote Tele-mentored Ultrasound Echocardiography for Cardiovascular Disease Diagnosis in Adults: A Systematic Review Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-06 M, a, n, a, l, , A, l, h, u, s, s, e, i, n
Cardiovascular diseases remain a major health challenge, leading to high rates of death and hospitalization globally. In the battle against these ailments, echocardiography stands as the frontline tool for diagnosis. Pioneering the charge in innovation, real-time remote tele-mentored ultrasound echocardiography (RTMUS echo) has emerged. This cutting-edge technique facilitates the instant transmission
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Development of a Novel Contrast-Enhanced Ultrasound-Based Nomogram for Superficial Lymphadenopathy Differentiation: Postvascular Phase Value Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-05 Ying Fu, Li-Gang Cui, Jiu-Yi Ma, Mei Fang, Yu-Xuan Lin, Nan Li
The aim of this study was to develop and prospectively validate a prediction model for superficial lymphadenopathy differentiation using Sonazoid contrast-enhanced ultrasound (CEUS) combined with ultrasound (US) and clinical data. The training cohort comprised 260 retrospectively enrolled patients with 260 pathological lymph nodes imaged between January and December 2020. Two clinical US-CEUS models
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A Pilot Study on Novel Use of Color Doppler Imaging for Navigation of Wiring in Coronary Interventions Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-03-02 Minako Katayama, Eric H. Yang, Marek Belohlavek
To test the Doppler guide wire (DGW) for navigation of the wire positioning by color Doppler ultrasound in the setting of percutaneous coronary intervention (PCI). An acoustically active DGW was tested in a water tank before its in vivo use. A waveform generator was connected to the DGW, and a transducer scanned the DGW to visualize a Doppler shift signal between the vibrating piezoelectric crystal
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Assessment of Neurovascular Coupling by Spectral Analysis of Cerebral Blood Flow Velocity With Transcranial Doppler Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-28 Juliana Ferreira, Patrícia Ferreira, Elsa Azevedo, Pedro Castro
Neurovascular coupling (NVC) represents the increase in regional blood flow associated with neural activity. The aim here was to describe a new approach to non-invasive measurement of NVC by spectral analysis of the cerebral blood flow velocity (CBFV) with transcranial Doppler. In a sample of 20 healthy participants, we monitored systolic CBFV in the left posterior cerebral artery (PCA) during off
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Influence of Power-Weighted Center of Echo Signal Within Window Function on Local Strain Rate Distribution in Left Ventricular Wall Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-26 Yu Obara, Shohei Mori, Masumi Iwai-Takano, Mototaka Arakawa, Hiroshi Kanai
The deviation of the power-weighted center of the echo signal from the geometric center within the velocity estimation window for calculating strain rate (SR) causes an estimation error. This study aimed to confirm whether an erroneous multilayer pattern in the SR distribution of the left ventricular wall could be corrected by considering the power-weighted center of the echo signal. The SR distributions
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An Adaptive Harmonic Separation Technique for Ultrasound Harmonic Imaging Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-26 Hansol Yoon, Tai-Kyong Song
An adaptive harmonic separation (HS) technique is proposed to overcome the limitations in conventional filtering techniques for ultrasound (US) tissue harmonic imaging (THI). Based on expectation-maximization source separation, the proposed HS technique adaptively models the depth-varying fundamental and harmonic components in the frequency domain and separates the two by applying their calculated
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Quantifying Plantar Flexor Muscles Stiffness During Passive and Active Force Generation Using Shear Wave Elastography in Individuals With Chronic Stroke Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-19 Kalthoum Belghith, Mustapha Zidi, Jean Michel Fedele, Rayan Bou-Serhal, Wael Maktouf
This study aims to investigate the mechanical properties of paretic and healthy plantar flexor muscles and assesses the spatial distribution of stiffness between the gastrocnemius medialis (GM) and lateralis (GL) during active force generation. Shear wave elastography measurements were conducted on a control group (CNT, n=14; age=59.9±10.6 years; BMI=24.5±2.5 kg/m) and a stroke survivor group (SSG
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Diagnostic Performance of Deep Learning in Video-Based Ultrasonography for Breast Cancer: A Retrospective Multicentre Study Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-17 Jing Chen, Zhibin Huang, Yitao Jiang, Huaiyu Wu, Hongtian Tian, Chen Cui, Siyuan Shi, Shuzhen Tang, Jinfeng Xu, Dong Xu, Fajin Dong
Although ultrasound is a common tool for breast cancer screening, its accuracy is often operator-dependent. In this study, we proposed a new automated deep-learning framework that extracts video-based ultrasound data for breast cancer screening. Our framework incorporates DenseNet121, MobileNet, and Xception as backbones for both video- and image-based models. We used data from 3907 patients to train
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Arterial Adventitial Vasa Vasorum Density Reflects The Progression Of Unstable Plaques: A Retrospective Clinical Study Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-16 Jiemei Yang, Penghao Gao, Qiannan Li, Tengyu Wang, Shuyuan Guo, Jingyu Zhang, Tianyi Zhang, Guodong Wu, Yuanyuan Guo, Zeng Wang, Ye Tian
Arterial adventitial vasa vasorum (AVV) plays an important role in the occurrence and development of atherosclerotic (AS) disease. AS is a systemic disease, and plaque is not only a local vascular event, but also occurs at multiple sites throughout the vascular bed. Currently, effective anti-AVV therapies are lacking. Therefore, we posed the following scientific questions: “does human carotid adventitial
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Evaluating the Effects of Water Balloons on High-Intensity Focused Ultrasound for Treating Uterine Fibroids Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-14 Yanhua Chen, Fenglong Zhao, Lian Feng, Fang Zhou, Xiaowei Zhou
In the treatment of uterine fibroids with ultrasound-guided high-intensity focused ultrasound (HIFU), water balloons are considered to be a valuable aid for improving safety and efficiency. However, the water balloons worsen the pathway for acoustic transmission, causing degraded performance both in ultrasound therapy and in ultrasound imaging. This study was aimed at establishing a protocol to evaluate
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Comparison of Micro-flow Imaging and Contrast-Enhanced Ultrasound in Ultrasound-Guided Microwave Ablation of Benign Thyroid Nodules Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-13 Min Zhuang, Man Lu, Zirui Jiang, Yin Liang, Shishi Wang, Lu Wang, Jiami Li
The study described here was aimed at ascertaining the utility of micro-flow imaging (MFI) during ultrasound (US)-guided microwave ablation (MWA) of thyroid nodules by contrasting its effectiveness with that of contrast-enhanced ultrasound (CEUS). Seventy-three patients with eighty-eight thyroid nodules who underwent US-guided MWA were included in our study from January 2020 to June 2023. Thirty-five
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FUSC: Fetal Ultrasound Semantic Clustering of Second-Trimester Scans Using Deep Self-Supervised Learning Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-13 Hussain Alasmawi, Leanne Bricker, Mohammad Yaqub
The aim of this study was address the challenges posed by the manual labeling of fetal ultrasound images by introducing an unsupervised approach, the fetal ultrasound semantic clustering (FUSC) method. The primary objective was to automatically cluster a large volume of ultrasound images into various fetal views, reducing or eliminating the need for labor-intensive manual labeling. The FUSC method
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Automatic Assessment of Ultrasound Curvature Angle for Scoliosis Detection Using 3-D Ultrasound Volume Projection Imaging Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-13 Sunetra Banerjee, Zixun Huang, Juan Lyu, Frank H.F. Leung, Timothy Lee, De Yang, Yongping Zheng, Jeb McAviney, Sai Ho Ling
Scoliosis is a spinal deformation in which the spine takes a lateral curvature, generating an angle in the coronal plane. The conventional method for detecting scoliosis is measurement of the Cobb angle in spine images obtained by anterior X-ray scanning. Ultrasound imaging of the spine is found to be less ionising than traditional radiographic modalities. For posterior ultrasound scanning, alternate
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Mitral Valve Segmentation and Tracking from Transthoracic Echocardiography Using Deep Learning Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-09 Sigurd Vangen Wifstad, Henrik Agerup Kildahl, Bjørnar Grenne, Espen Holte, Ståle Wågen Hauge, Sigbjørn Sæbø, Desalew Mekonnen, Berhanu Nega, Rune Haaverstad, Mette-Elise Estensen, Håvard Dalen, Lasse Lovstakken
Valvular heart diseases (VHDs) pose a significant public health burden, and deciding the best treatment strategy necessitates accurate assessment of heart valve function. Transthoracic echocardiography (TTE) is the key modality to evaluate VHDs, but the lack of standardized quantitative measurements leads to subjective and time-consuming assessments. We aimed to use deep learning to automate the extraction
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Normalized Spatial Autocorrelation in Ultrasound B-Mode Imaging for Point-Scatterer Detection Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-08 Cuijuan Lou, Zhaohui Liu, Ming Yuchi, Mingyue Ding
Point-scatterer detection plays a key role in medical ultrasound B-mode imaging. Speckle noise and insufficient spatial resolution are important factors affecting point-scatterer detection. To address this issue, normalized spatial autocorrelation in ultrasound B-mode imaging (NSACB) is proposed. First, the acquired data are pre-processed by adding Gaussian white noise (GWN) with a certain signal-to-Gaussian
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Using 3-D-Printed Structures to Evaluate the Potential Causes of the Color Doppler Twinkling Signature Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-07 Benjamin G. Wood, Renc Saracaydin, Seth A. Hara, Christine U. Lee, Matthew W. Urban
The color Doppler twinkling artifact has been attributed to existing microbubbles or cavitation occurring on rough objects such as kidney stones, some breast biopsy clips, catheter guidewires and sandpaper. The objective was to investigate the correlation between the surface characteristics of helical constructs with different groove geometries and the occurrence of twinkling, as well as to identify
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Enhancement of Tumor Perfusion and Antiangiogenic Therapy in Murine Models of Clear Cell Renal Cell Carcinoma Using Ultrasound-Stimulated Microbubbles Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-03 Juan Wang, Tingting Luo, Jianghong Chen, Zheng Liu, Juan Wang, Xiaolin Zhang, Hui Li, Yulin Ma, Fan Zhang, Hongjuan Ju, Wengang Wang, Yueheng Wang, Qiong Zhu
To explore the effect of ultrasound-stimulated microbubble cavitation (USMC) on enhancing antiangiogenic therapy in clear cell renal cell carcinoma. We explored the effects of USMC with different mechanical indices (MIs) on tumor perfusion, 36 786-O tumor-bearing nude mice were randomly assigned into four groups: (i) control group, (ii) USMC group (MI = 0.25), (iii) USMC group (MI = 1.4) (iv) US group
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Characterization of Blood–Brain Barrier Opening Induced by Transcranial Histotripsy in Murine Brains Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-02-01 Sarah Duclos, Sang Won Choi, Anuska V. Andjelkovic, Neeraj Chaudhary, Sandra Camelo-Piragua, Aditya Pandey, Zhen Xu
Transcranial histotripsy has shown promise as a non-invasive neurosurgical tool, as it has the ability to treat a wide range of locations in the brain without overheating the skull. One important effect of histotripsy in the brain is the blood–brain barrier (BBB) opening (BBBO) at the ablation site, but there is a knowledge gap concerning the extent of histotripsy-induced BBBO. Here we describe induction
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Low-Intensity Pulsed Ultrasound Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity by Upregulating Neurotrophic Factors Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-30 Yu-Cheng Liu, Wei-Shen Su, Tai-Ho Hung, Feng-Yi Yang
Objective Neonatal hypoxic-ischemic brain damage (HIBD) can have long-term implications on patients’ physical and mental health, yet the available treatment options are limited. Recent research has shown that low-intensity pulsed ultrasound (LIPUS) holds promise for treating neurodegenerative diseases and traumatic brain injuries. Our objective was to explore the therapeutic potential of LIPUS for
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Automated Segmentation and Quantification of the Right Ventricle in 2-D Echocardiography Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-29 Artem Chernyshov, Jahn Frederik Grue, John Nyberg, Bjørnar Grenne, Håvard Dalen, Svein Arne Aase, Andreas Østvik, Lasse Lovstakken
Objective The right ventricle receives less attention than its left counterpart in echocardiography research, practice and development of automated solutions. In the work described here, we sought to determine that the deep learning methods for automated segmentation of the left ventricle in 2-D echocardiograms are also valid for the right ventricle. Additionally, here we describe and explore a keypoint
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Ultrasound Shear Wave Propagation Modeling in General Tissue–Like Viscoelastic Materials Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-29 Mariusz Osika, Piotr Kijanka
Objective This study aims to present an approach for the simulation of ultrasound elastic waves propagation in a diverse range of heterogeneous tissue-like viscoelastic materials, including, but not limited to, Kelvin-Voigt, Zener, Maxwell, Burger's, and Maxwell-Wiechert models, while also allowing for modeling highly viscous fluids. Methods Ultrasound shear wave elastography (SWE) serves as a cost-effective
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Predictive Model of CK7 Expression in Patients With Clear Cell Renal Cell Carcinoma by Combined Multimodal Ultrasound Diagnostic Techniques: A Retrospective Study Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-27 Yi-Fan Zhu, Mao-Lin Liu, Wen-Ting Zheng, Fen Fu, En-Sheng Xue, Xiao-Qing Fan, Hui-Ping Zhang, Guang-Tian Lian, Qin Ye
Objective The aim of the work described here was to develop and validate a predictive model for cytokeratin 7 (CK7) expression in clear cell renal cell carcinoma (ccRCC) patients by combining multimodal ultrasound diagnostic techniques. Methods This retrospective study enrolled 157 surgically confirmed ccRCC patients. All patients underwent pre-operative multimodal ultrasound diagnostic examinations
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In Vivo Ultrasound Shear Wave Elastography Assessment of Acute Compartment Syndrome in a Turkey Model Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-28 Ye Ren, Yoichi Toyoshima, Alyssa Vrieze, Brett Freedman, Azra Alizad, Chunfeng Zhao
Objective The aim of the work described here was to evaluate the objectivity and reproducibility of non-invasive intra-compartment pressure (ICP) measurement using ultrasound shear wave elastography (SWE) in a turkey model in vivo and to determine the biological and histologic changes in acute compartment syndrome (ACS). Methods Twenty-four turkeys were randomly divided into four groups based on the
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Diagnostic and Prognostic Ability of Contrast-Enhanced Unltrasound and Biomarkers in Hepatocellular Carcinoma Subtypes Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-27 Wenxin Xu, Biyu Huang, Rui Zhang, Xian Zhong, Wenwen Zhou, Shimei Zhuang, Xiaoyan Xie, Jianhong Fang, Ming Xu
Objective To investigate the diagnostic and prognostic value of contrast-enhanced ultrasound (CEUS) and clinical indicators of the vessels encapsulating tumor clusters (VETC) pattern and macrotrabecular-massive subtype in hepatocellular carcinoma (MTM-HCC). Methods This retrospective study included patients who underwent preoperative CEUS and hepatectomy for HCC between August 2018 and August 2021
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An Easy and Effective Method for Evaluating the Position of Conus Medullaris: Counting the Number of Vertebral Ossification Center Below the End of Conus Medullaris Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-27 Dandan Luo, Xiaohong Zhong, Shuihua Yang, Huaxuan Wen, Yi Huang, Yue Qin, Meiling Liang, Yimei Liao, Qing Zeng, Ying Yuan, Shengli Li
Objective This study aimed to ascertain the conus medullaris position by counting the number of ossification centers in the vertebral bodies below the conus medullaris endpoint (N) and assess its utility in screening for closed spinal dysraphism and tethered cord syndrome. Methods A total of 900 normal fetuses and 146 fetuses with closed spinal dysraphism or tethered cord syndrome were included in
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Relationship Between the Changes of Tendon Elastic Moduli With Ultrasound Shear Wave Elastography and Mechanical Compression Test Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-25 Naoya Iida, Andrew R. Thoreson, Ramona L. Reisdorf, Ichiro Tsukamoto, Hicham El Hor, Chunfeng Zhao
Objective The purpose of this study was to investigate the consistency of the changes in the elastic modulus measured with ultrasound shear wave elastography (SWE) with changes measured through mechanical testing using tendons that were artificially altered by chemical modifications. Methods Thirty-six canine flexor digitorum profundus tendons were used for this experiment. To mimic tendon mechanical
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Evaluation of Turbulence Index and Flow Pattern for Atherosclerotic Carotid Stenosis: A High-Frame-Rate Vector Flow Imaging Study Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-23 Yinghui Dong, Wenjing Gao, Shaofu Hong, Di Song, Mengmeng Liu, Yigang Du, Jinfeng Xu, Fajin Dong
Objective The emerging high-frame-rate vector flow imaging provides a new way of hemodynamic evaluation for complex blood flow. This study was aimed at exploring quantitatively the characteristics of complex flow with turbulence (Tur) index and analyzing flow patterns in atherosclerotic internal carotid artery stenosis (ICAS) using high-frame-rate vector flow imaging. Methods This study prospectively
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Reliability of Ultrasound Shear Wave Elastography for Evaluating Psoas Major and Quadratus Lumborum Stiffness: Gender and Physical Activity Effects Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-24 Emma Feng Ming Zhou, Arnold Yu Lok Wong, Yong Ping Zheng, Siu Ngor Fu, King Hei Stanley Lam
Objective We aimed to assess the reliability of quantifying psoas major (PM) and quadratus lumborum (QL) stiffness with ultrasound shear wave elastography (SWE), and to explore the effects of gender and physical activity on muscle stiffness. Methods Fifty-two healthy participants (18–32 y) were recruited. To determine reliability, 29 of them underwent repeated SWE measurements of PM and QL stiffness
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Thyroid Ultrasound Image Database and Marker Mask Inpainting Method for Research and Development Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-23 Xiang Li, Chong Fu, Sen Xu, Chiu-Wing Sham
Objective The main objective of this study was to build a rich and high-quality thyroid ultrasound image database (TUD) for computer-aided diagnosis (CAD) systems to support accurate diagnosis and prognostic modeling of thyroid disorders. Because most of the raw thyroid ultrasound images contain artificial markers, which seriously affect the robustness of CAD systems because of their strong prior location
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Development and Validation of a Nomogram Based on Multimodality Ultrasonography Images for Differentiating Malignant from Benign American College of Radiology Thyroid Imaging, Reporting and Data System (TI-RADS) 3–5 Thyroid Nodules Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-22 Lina Pang, Xiao Yang, Peidi Zhang, Lei Ding, Jiani Yuan, Haijing Liu, Jin Liu, Xue Gong, Ming Yu, Wen Luo
Objective The aim of the work described here was to develop and validate a predictive nomogram based on combined image features of gray-scale ultrasonography (US), elastosonography (ES) and contrast-enhanced US (CEUS) to differentiate malignant from benign American College of Radiology Thyroid Imaging, Reporting and Data System (ACR TI-RADS) 3–5 thyroid nodules. Methods Among 2767 thyroid nodules scanned
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Evaluation of the Time Difference Method in Identifying Hepatocellular Carcinoma in Current CEUS LR-M Category Nodules Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-20 Li-jin Shao, Yan-jie Wang, Shan-shan Yin, Bin-bin Jiang, Yu-hui Liu, Ji-chen Wang, Wei Yang, Wei Wu, Kun Yan
Objective The aim of the work described here was to explore a potential method for improving the diagnostic detection of hepatocellular carcinoma (HCC) based on the contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) Version 2017. Methods We retrospectively evaluated 585 liver nodules in 427 patients at risk for HCC from December 2020 to March 2023. The nodules were
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Is the Corrected Carotid Flow Time a Clinically Acceptable Surrogate Hemodynamic Parameter for the Left Ventricular Ejection Time? Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-19 Joris van Houte, Rob Eerdekens, Fokko Manning, Mariska te Pas, Saskia Houterman, Inge Wijnbergen, Leon Montenij, Pim Tonino, Arthur Bouwman
Objective The corrected left ventricular ejection time (cLVET) comprises the phase from aortic valve opening to aortic valve closure corrected for heart rate. As a surrogate measure for cLVET, the corrected carotid flow time (ccFT) has been proposed in previous research. The aim of this study was to assess the clinical agreement between cLVET and ccFT in a dynamic clinical setting. Methods Twenty-five
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Adaptation of a Clinical High-Frequency Transrectal Ultrasound System for Prostate Photoacoustic Imaging: Implementation and Pre-clinical Demonstration Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-18 Nidhi Singh, Emmanuel Chérin, Carlos-Felipe Roa, Yohannes Soenjaya, Brian Wodlinger, Gang Zheng, Brian C. Wilson, F. Stuart Foster, Christine E.M. Demore
Objective High-frequency, high-resolution transrectal micro-ultrasound (micro-US: ≥15 MHz) imaging of the prostate is emerging as a beneficial tool for scoring disease risk and accurately targeting biopsies. Adding photoacoustic (PA) imaging to visualize abnormal vascularization and accumulation of contrast agents in tumors has potential for guiding focal therapies. In this work, we describe a new
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Ultrafast Doppler Imaging for Early Detection of Synovitis in Rheumatoid Arthritis Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-19 Kuo-Lung Lai, Min-Chieh Tsai, Pai-Chi Li
Objective Current medical ultrasound systems possess limited sensitivity in detecting slow and weak blood flow during the early stages of rheumatoid arthritis (RA), leading to potential misdiagnosis. Ultrafast Doppler is capable of detecting slow and weak flow. This study was aimed at evaluating the diagnostic value of ultrafast Doppler for RA. Methods Thirty-three RA patients (19 established, 14 early
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The Effect of Steatosis on Shear-Wave Velocity and Viscoelastic Properties Related to Liver Fibrosis Progression in Rat Models Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-17 Kazuki Tamura, Kazuyo Ito, Riwa Kishimoto, Kenji Yoshida, Takashi Kishimoto, Takayuki Obata, Tadashi Yamaguchi
Objective Hepatic fibrosis has recently been evaluated using ultrasonography or magnetic resonance elastography. Although the shear wave velocity (SWV) obtained using point shear wave elastography (pSWE) provides a valuable measure of fibrosis, underlying steatosis may affect its measurement. Methods Using hepatic fibrosis samples, this study evaluated the effect of steatosis on the shear wave velocity
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Non-Invasive Diagnosis of Prostate Cancer and High-Grade Prostate Cancer Using Multiparametric Ultrasonography and Serological Examination Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-17 Jia Li, Chengwei Zhu, Shiping Yang, Zhenshen Mao, Shuting Lin, Hang Huang, Shihao Xu
Objectives This study aimed to assess the efficacy of multiparametric ultrasonography (mpUS) combined with serological examination, as a non-invasive method, in detecting prostate cancer (PCa) or high-grade prostate cancer (HGPCa) respectively. Methods A cohort of 245 individuals with clinically suspected PCa were enrolled. All subjects underwent a comprehensive evaluation, including basic data collection
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Evaluating Skin Involvement in Systemic Sclerosis Using High-Frequency Ultrasound and Virtual Touch Tissue Imaging Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-16 Dao-Rong Hong, Chun-Yan Huang, Zhen-Hong Xu
Objective This study aimed to explore the diagnostic significance of high-frequency ultrasound combined with visual touch tissue imaging quantification (VTIQ) in the diagnosis and management of systemic sclerosis (SSc). Methods Patients diagnosed with SSc and normal volunteers were recruited and divided into an experimental group and a control group, with 30 cases in each group, respectively. The skin
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Editorial Advisory Board Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-16
Abstract not available
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Ultrasound Pressure-Dependent Cytokine and Immune Cell Response Lost in Aged Muscle Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-12 Chelsey L. Dunham, Joseph A. Frank
Objective Therapeutic ultrasound remains a highly discussed topic in physical therapy due to uncertainty between treatment regimens and biological benefits. Its impact on aged populations, who are vulnerable to insufficient healing after muscle injury because of sarcopenia, is understudied. Despite the coupling between muscle inflammation and regeneration, research on the immune response after therapeutic
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Biopathologic Characterization and Grade Assessment of Breast Cancer With 3-D Multiparametric Ultrasound Combining Shear Wave Elastography and Backscatter Tensor Imaging Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-08 Jean-Baptiste Guillaumin, Lounes Djerroudi, Jean-François Aubry, Anne Tardivon, Alexandre Dizeux, Mickaël Tanter, Anne Vincent-Salomon, Béatrice Berthon
Objective Despite recent improvements in medical imaging, the final diagnosis and biopathologic characterization of breast cancers currently still requires biopsies. Ultrasound is commonly used for clinical examination of breast masses. B-Mode and shear wave elastography (SWE) are already widely used to detect suspicious masses and differentiate benign lesions from cancers. But additional ultrasound
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Automated Measurement of Ovary Development in Atlantic Salmon Using Deep Learning Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-08 Yasin Yari, Ingun Næve, Asle Hammerdal, Per Helge Bergtun, Svein-Erik Måsøy, Marco Marien Voormolen, Lasse Lovstakken
Objective Salmon breeding companies control the egg stripping period through environmental change, which triggers the need to identify the state of maturation. Ultrasound imaging of the salmon ovary is a proven non-invasive tool for this purpose; however, the process is laborious, and the interpretation of the ultrasound scans is subjective. Real-time ultrasound image segmentation of Atlantic salmon
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Assessment of Basic Thoracic Ultrasound Skills in Immersive Virtual Reality: Gathering Validity Evidence Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-06 Anders Bo Nielsen, Jonas Dragsbæk, Niels Jacobsen, Christian B. Laursen, Amy Farr, Marek Slavicky, Lars Konge, Pia Iben Pietersen
Objective Operator skills are essential for thoracic ultrasound (TUS) to ensure diagnostic accuracy. Immersive virtual reality (IVR) has shown potential within medical education but never for assessment of TUS skills. This study was aimed at developing an IVR test for assessing TUS skills, gathering validity evidence and establishing a pass/fail score. Methods An expert panel developed a test based
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Safety Review of Therapeutic Ultrasound for Spinal Cord Neuromodulation and Blood–Spinal Cord Barrier Opening Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-05 Rui Xu, Bradley E. Treeby, Eleanor Martin
New focused ultrasound spinal cord applications have emerged, particularly those improving therapeutic agent delivery to the spinal cord via blood–spinal cord barrier opening and the neuromodulation of spinal cord tracts. One hurdle in the development of these applications is safety. It may be possible to use safety trends from seminal and subsequent works in focused ultrasound to guide the development
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Reply to “Critique of a Study on Breast Ultrasound as an Adjunct to Breast Tomosynthesis for Breast Cancer Screening and Diagnosis” Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-04 Kartini Rahmat, Nazimah Ab Mumin
Abstract not available
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BPSegSys: A Brachial Plexus Nerve Trunk Segmentation System Using Deep Learning Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-04 Yu Wang, Binbin Zhu, Lingsi Kong, Jianlin Wang, Bin Gao, Jianhua Wang, Dingcheng Tian, Yudong Yao
Objective Ultrasound-guided nerve block anesthesia (UGNB) is a high-tech visual nerve block anesthesia method that can be used to observe the target nerve and its surrounding structures, the puncture needle's advancement and local anesthetics spread in real time. The key in UGNB is nerve identification. With the help of deep learning methods, the automatic identification or segmentation of nerves can
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Direct Emulsification of Stable Superheated Perfluorobutane Nanodroplets by Sonication: Addressing the Limitations of the Microbubble Condensation Technique Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-03 Adam Woodward, Robert F. Mattrey, Caroline de Gracia Lux
Objective We have previously determined that direct formulation of a phospholipid-based perfluorobutane (PFB) emulsion using high-pressure homogenization produces monodispersed PFB nanodroplets (NDs) with relatively few non-PFB-filled NDs. In this article, we describe a simpler strategy to reproducibly formulate highly concentrated superheated PFB NDs using a probe sonicator, a more widely available
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3-D Contrast-Enhanced Fusion Ultrasound for Accurate Volume Assessment of Vessel Lumen and Plaque in Carotid Artery Disease as Compared With Computed Tomography Angiography Ultrasound Med. Biol. (IF 2.9) Pub Date : 2024-01-03 Karin Yeung, Jonas Peter Eiberg, Antoine Collet-Billon, Benjamin Vikjær Sandholt, Majken Lyhne Jessen, Henrik Hegaard Sillesen, Nikolaj Eldrup
Objective Three-dimensional contrast-enhanced fusion ultrasound (CEFUS) of atherosclerotic carotid arteries provides spatial visualization of the vessel lumen, creating a lumenography. As in 3-D computed tomography angiography (CTA), 3-D CEFUS outlines the contrast-filled lumen. Plaque and vessel contours are distinguished in 3-D CEFUS, allowing plaque volume quantification as a valid estimate of carotid
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Corrigendum to ‘Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model’ [Ultrasound in Med & Biol. 49 (2023) 1082-1090] Ultrasound Med. Biol. (IF 2.9) Pub Date : 2023-12-30 Yanrong Zhang, Jing Wang, Sara Natasha Ghobadi, Haiyan Zhou, Ai Huang, Marco Gerosa, Qingyi Hou, Olivier Keunen, Anna Golebiewska, Frezghi G. Habte, Gerald A. Grant, Ramasamy Paulmurugan, Kevin S. Lee, Max Wintermark
Abstract not available