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Lung retention and particokinetics of silver and gold nanoparticles in rats following subacute inhalation co-exposure Part. Fibre Toxicol. (IF 7.546) Pub Date : 2021-01-21 Jin Kwon Kim; Hoi Pin Kim; Jung Duck Park; Kangho Ahn; Woo Young Kim; Mary Gulumian; Günter Oberdörster; Il Je Yu
Inhalation exposure to nanomaterials in workplaces can include a mixture of multiple nanoparticles. Such ambient nanoparticles can be of high dissolution or low dissolution in vivo and we wished to determine whether co-exposure to particles with different dissolution rates affects their biokinetics. Rats were exposed to biosoluble silver nanoparticles (AgNPs, 10.86 nm) and to biopersistent gold nanoparticles
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Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation Part. Fibre Toxicol. (IF 7.546) Pub Date : 2021-01-09 Yen-Ju Chan; Po-Lin Liao; Chi-Hao Tsai; Yu-Wen Cheng; Fan-Li Lin; Jau-Der Ho; Ching-Yi Chen; Ching-Hao Li
Depending on their distinct properties, titanium dioxide nanoparticles (TiO2-NPs) are manufactured extensively and widely present in our daily necessities, with growing environmental release and public concerns. In sunscreen formulations, supplementation of TiO2-NPs may reach up to 25% (w/w). Ocular contact with TiO2-NPs may occur accidentally in certain cases, allowing undesirable risks to human vision
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Exposure to diesel exhaust particles results in altered lung microbial profiles, associated with increased reactive oxygen species/reactive nitrogen species and inflammation, in C57Bl/6 wildtype mice on a high-fat diet Part. Fibre Toxicol. (IF 7.546) Pub Date : 2021-01-08 Sarah Daniel; Danielle Phillippi; Leah J. Schneider; Kayla N. Nguyen; Julie Mirpuri; Amie K. Lund
Exposure to traffic-generated emissions is associated with the development and exacerbation of inflammatory lung disorders such as chronic obstructive pulmonary disorder (COPD) and idiopathic pulmonary fibrosis (IPF). Although many lung diseases show an expansion of Proteobacteria, the role of traffic-generated particulate matter pollutants on the lung microbiota has not been well-characterized. Thus
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Cardiovascular health impacts of wildfire smoke exposure Part. Fibre Toxicol. (IF 7.546) Pub Date : 2021-01-07 Hao Chen; James M. Samet; Philip A. Bromberg; Haiyan Tong
In recent years, wildland fires have occurred more frequently and with increased intensity in many fire-prone areas. In addition to the direct life and economic losses attributable to wildfires, the emitted smoke is a major contributor to ambient air pollution, leading to significant public health impacts. Wildfire smoke is a complex mixture of particulate matter (PM), gases such as carbon monoxide
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Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes Part. Fibre Toxicol. (IF 7.546) Pub Date : 2021-01-06 Monia Savi; Leonardo Bocchi; Francesca Cacciani; Rocchina Vilella; Annamaria Buschini; Alessio Perotti; Serena Galati; Serena Montalbano; Silvana Pinelli; Caterina Frati; Emilia Corradini; Federico Quaini; Roberta Ruotolo; Donatella Stilli; Massimiliano Zaniboni
Nanotoxicology is an increasingly relevant field and sound paradigms on how inhaled nanoparticles (NPs) interact with organs at the cellular level, causing harmful conditions, have yet to be established. This is particularly true in the case of the cardiovascular system, where experimental and clinical evidence shows morphological and functional damage associated with NP exposure. Giving the increasing
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Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-12-07 Kelly Fraser; Vamsi Kodali; Naveena Yanamala; M. Eileen Birch; Lorenzo Cena; Gary Casuccio; Kristin Bunker; Traci L. Lersch; Douglas E. Evans; Aleksandr Stefaniak; Mary Ann Hammer; Michael L. Kashon; Theresa Boots; Tracy Eye; John Hubczak; Sherri A. Friend; Matthew Dahm; Mary K. Schubauer-Berigan; Katelyn Siegrist; David Lowry; Alison K. Bauer; Linda M. Sargent; Aaron Erdely
Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to their fundamental material characteristics was lacking. It was unclear if all CNT/F confer similar toxicity, in particular, genotoxicity. Nine CNT/F (MW #1–7 and CNF #1–2), commonly found
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The critical role of endothelial function in fine particulate matter-induced atherosclerosis Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-12-04 Shuang Liang; Jingyi Zhang; Ruihong Ning; Zhou Du; Jiangyan Liu; Joe Werelagi Batibawa; Junchao Duan; Zhiwei Sun
Ambient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate matter (PM2.5) plays a major mortality risk factor particularly on cardiovascular diseases through mechanisms of atherosclerosis, thrombosis and inflammation. A review on the PM2.5-induced atherosclerosis
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The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-11-26 Alexia J. Taylor-Just; Mark D. Ihrie; Katherine S. Duke; Ho Young Lee; Dorothy J. You; Salik Hussain; Vamsi K. Kodali; Christina Ziemann; Otto Creutzenberg; Adriana Vulpoi; Flaviu Turcu; Monica Potara; Milica Todea; Sybille van den Brule; Dominique Lison; James C. Bonner
Inhalation of multi-walled carbon nanotubes (MWCNTs) poses a potential risk to human health. In order to safeguard workers and consumers, the toxic properties of MWCNTs need to be identified. Functionalization has been shown to either decrease or increase MWCNT-related pulmonary injury, depending on the type of modification. We, therefore, investigated both acute and chronic pulmonary toxicity of a
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Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-11-26 Hsiao-Chi Chuang; Hsin-Chang Chen; Pei-Jui Chai; Ho-Tang Liao; Chang-Fu Wu; Chia-Ling Chen; Ming-Kai Jhan; Hui-I Hsieh; Kuen-Yuh Wu; Ta-Fu Chen; Tsun-Jen Cheng
Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions
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Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-11-16 Lauren H. Wyatt; Robert B. Devlin; Ana G. Rappold; Martin W. Case; David Diaz-Sanchez
Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies. To measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, young volunteers to PM2.5, in the form of concentrated ambient particles (mean: 37.8 μg/m3, SD 6.5),
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Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-11-12 Nell Hirt; Mathilde Body-Malapel
Together with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due to food processes and
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Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-11-02 Eva Bongaerts; Tim S. Nawrot; Thessa Van Pee; Marcel Ameloot; Hannelore Bové
Fetal development is a crucial window of susceptibility in which exposure may lead to detrimental health outcomes at birth and later in life. The placenta serves as a gatekeeper between mother and fetus. Knowledge regarding the barrier capacity of the placenta for nanoparticles is limited, mostly due to technical obstacles and ethical issues. We systematically summarize and discuss the current evidence
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Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-10-24 Sara B. Fournier; Jeanine N. D’Errico; Derek S. Adler; Stamatina Kollontzi; Michael J. Goedken; Laura Fabris; Edward J. Yurkow; Phoebe A. Stapleton
Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic and nanoplastic particulates are formed from bulk fragmentation and disintegration of plastic pollution. Plastic particulates have recently been detected in indoor air and remote atmospheric fallout. Due to their small size, microplastic and
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Even lobar deposition of poorly soluble gold nanoparticles (AuNPs) is similar to that of soluble silver nanoparticles (AgNPs) Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-10-20 Hoi Pin Kim; Jin Kwon Kim; Mi Seong Jo; Jung Duck Park; Kangho Ahn; Mary Gulumian; Günter Oberdörster; Il Je Yu
Information on particle deposition, retention, and clearance is important when evaluating the risk of inhaled nanomaterials to human health. The revised Organization Economic Cooperation and Development (OECD) inhalation toxicity test guidelines now require lung burden measurements of nanomaterials after rodent subacute and sub-chronic inhalation exposure (OECD 412, OECD 413) to inform on lung clearance
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Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-10-16 Xiaoli Feng; Yaqing Zhang; Chao Zhang; Xuan Lai; Yanli Zhang; Junrong Wu; Chen Hu; Longquan Shao
Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of
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Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-10-15 Timothy Smyth; Janelle Veazey; Sophia Eliseeva; David Chalupa; Alison Elder; Steve N. Georas
While exposure to diesel exhaust particles has been linked to aberrant immune responses in allergic diseases such as asthma, little attention has been paid to their effects on the airway epithelial barrier. In this study, we sought to determine the effect of diesel exhaust exposure on airway epithelial barrier function and composition using in vitro and in vivo model systems. 16HBE14o- human bronchial
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Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-10-15 Dina Mourad Saleh; William T. Alexander; Takamasa Numano; Omnia Hosny Mohamed Ahmed; Sivagami Gunasekaran; David B. Alexander; Mohamed Abdelgied; Ahmed M. El-Gazzar; Hiroshi Takase; Jiegou Xu; Aya Naiki-Ito; Satoru Takahashi; Akihiko Hirose; Makoto Ohnishi; Jun Kanno; Hiroyuki Tsuda
Multi-walled carbon nanotubes can be divided into two general subtypes: tangled and straight. MWCNT-N (60 nm in diameter) and MWCNT-7 (80–90 nm in diameter) are straight-type MWCNTs, and similarly to asbestos, both are carcinogenic to the lung and pleura when administered to rats via the airway. Injection of straight-type MWCNTs into the peritoneal cavity also induces the development of mesothelioma
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Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-10-07 A. Guillard; E. Gaultier; C. Cartier; L. Devoille; J. Noireaux; L. Chevalier; M. Morin; F. Grandin; M. Z. Lacroix; C. Coméra; A. Cazanave; A. de Place; V. Gayrard; V. Bach; K. Chardon; N. Bekhti; K. Adel-Patient; C. Vayssière; P. Fisicaro; N. Feltin; F. de la Farge; N. Picard-Hagen; B. Lamas; E. Houdeau
Titanium dioxide (TiO2) is broadly used in common consumer goods, including as a food additive (E171 in Europe) for colouring and opacifying properties. The E171 additive contains TiO2 nanoparticles (NPs), part of them being absorbed in the intestine and accumulated in several systemic organs. Exposure to TiO2-NPs in rodents during pregnancy resulted in alteration of placental functions and a materno-foetal
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Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-10-02 Ru Ma; Yi Qi; Xinying Zhao; Xueyan Li; Xuejing Sun; Piye Niu; Yanbo Li; Caixia Guo; Rui Chen; Zhiwei Sun
The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been gradually confirmed, however, the interaction between SiNPs exposure and atherosclerosis, and the underlying mechanisms still remain unknown. Thereby, this study aimed to explore the effects of SiNPs on the progression
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Controlled human exposures to wood smoke: a synthesis of the evidence Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-10-02 Carley Schwartz; Anette Kocbach Bølling; Christopher Carlsten
Exposure to particulate matter (PM) from wood combustion represents a global health risk, encompassing diverse exposure sources; indoor exposures due to cooking in developing countries, ambient PM exposures from residential wood combustion in developed countries, and the predicted increasing number of wildfires due to global warming. Although physicochemical properties of the PM, as well as the exposure
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Occupational exposure to carbon black nanoparticles increases inflammatory vascular disease risk: an implication of an ex vivo biosensor assay Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-09-29 Jinglong Tang; Wenting Cheng; Jinling Gao; Yanting Li; Ruyong Yao; Nathaniel Rothman; Qing Lan; Matthew J. Campen; Yuxin Zheng; Shuguang Leng
Among manufactured or engineered nanoparticles, carbon black (CB) has largest production worldwide and is also an occupational respiratory hazard commonly seen in rubber industry. Few studies have assessed the risk for cardiovascular disease in carbon black exposed populations. An endothelial biosensor assay was used to quantify the capacity of sera from 82 carbon black packers (CBP) and 106 non-CBPs
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Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-09-18 Zixuan Liu,Xuying Lv,Lei Xu,Xuting Liu,Xiangyu Zhu,Erqun Song,Yang Song
With the development of zinc oxide nanoparticles (ZnO NPs) in the field of nanotechnology, their toxicological effects are attracting increasing attention, and the mechanisms for ZnO NPs neurotoxicity remain obscure. In an attempt to address concerns regarding neurotoxicity of ZnO NPs, we explored the relationship between free zinc ions, reactive oxygen species (ROS) and neurotoxic mechanisms in ZnO
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NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-09-18 Falko Frenzel,Laura König-Mattern,Valerie Stock,Linn Voss,Maxi B Paul,Holger Sieg,Albert Braeuning,Andreas Voigt,Linda Böhmert
Nanoparticles exhibit a specific diffusion and sedimentation behavior under cell culture conditions as used in nantoxicological in vitro testing. How a particular particle suspension behaves depends on the particular physicochemical characteristics of the particles and the cell culture system. Only a fraction of the nanoparticles applied to a cell culture will thus reach the cells within a given time
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Quartz crystal microbalances (QCM) are suitable for real-time dosimetry in nanotoxicological studies using VITROCELL®Cloud cell exposure systems. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-09-16 Yaobo Ding,Patrick Weindl,Anke-Gabriele Lenz,Paula Mayer,Tobias Krebs,Otmar Schmid
Accurate knowledge of cell−/tissue-delivered dose plays a pivotal role in inhalation toxicology studies, since it is the key parameter for hazard assessment and translation of in vitro to in vivo dose-response. Traditionally, (nano-)particle toxicological studies with in vivo and in vitro models of the lung rely on in silio computational or off-line analytical methods for dosimetry. In contrast to
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Carbon nanomaterial-derived lung burden analysis using UV-Vis spectrophotometry and proteinase K digestion. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-09-11 Dong-Keun Lee,Soyeon Jeon,Jiyoung Jeong,Kyung Seuk Song,Wan-Seob Cho
The quantification of nanomaterials accumulated in various organs is crucial in studying their toxicity and toxicokinetics. However, some types of nanomaterials, including carbon nanomaterials (CNMs), are difficult to quantify in a biological matrix. Therefore, developing improved methodologies for quantification of CNMs in vital organs is instrumental in their continued modification and application
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Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplasty. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-08-27 Jing Xu,Junyao Yang,Jian Chen,Xiaoli Zhang,Yuanhao Wu,Alister Hart,Agata Nyga,Julia C Shelton
The toxicity of released metallic particles generated in metal-on-metal (MoM) total hip arthroplasty (THA) using cobalt chromium (CoCr) has raised concerns regarding their safety amongst both surgeons and the public. Soft tissue changes such as pseudotumours and metallosis have been widely observed following the use of these implants, which release metallic by-products due to both wear and corrosion
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Particulate matters increase epithelial-mesenchymal transition and lung fibrosis through the ETS-1/NF-κB-dependent pathway in lung epithelial cells. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-08-14 Yu-Chen Chen,Tzu-Yi Chuang,Chen-Wei Liu,Chi-Wei Liu,Tzu-Lin Lee,Tsai-Chun Lai,Yuh-Lien Chen
Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress increased the expression of proinflammatory intracellular adhesion molecule-1 (ICAM-1) through the IL-6/AKT/STAT3/NF-κB pathway in A549 cells. However, the role of O-PMs in epithelial-mesenchymal
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Carbon nanotube filler enhances incinerated thermoplastics-induced cytotoxicity and metabolic disruption in vitro. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-08-12 Jayme P Coyle,Raymond C Derk,Tiffany G Kornberg,Dilpreet Singh,Jake Jensen,Sherri Friend,Robert Mercer,Todd A Stueckle,Philip Demokritou,Yon Rojanasakul,Liying W Rojanasakul
Engineered nanomaterials are increasingly being incorporated into synthetic materials as fillers and additives. The potential pathological effects of end-of-lifecycle recycling and disposal of virgin and nano-enabled composites have not been adequately addressed, particularly following incineration. The current investigation aims to characterize the cytotoxicity of incinerated virgin thermoplastics
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Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-08-10 Rongrong Wu,Johan Högberg,Mikael Adner,Patricia Ramos-Ramírez,Ulla Stenius,Huiyuan Zheng
Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and if new cases can be avoided by lowered permissible exposure levels. In this study we investigate early DNA damaging effects of low doses of silica particles in respiratory epithelial cells in vitro
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Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-08-08 Katja Maria Bendtsen,Louise Gren,Vilhelm Berg Malmborg,Pravesh Chandra Shukla,Martin Tunér,Yona J Essig,Annette M Krais,Per Axel Clausen,Trine Berthing,Katrin Loeschner,Nicklas Raun Jacobsen,Henrik Wolff,Joakim Pagels,Ulla Birgitte Vogel
Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 concentration: MK1 ultra low sulfur diesel (DEP13) and the two
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PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-08-04 Yu-Wen Chen,Mei-Zi Huang,Chyi-Liang Chen,Chieh-Ying Kuo,Chia-Yu Yang,Chuan Chiang-Ni,Yi-Ywan M Chen,Chia-Ming Hsieh,Hui-Yu Wu,Ming-Ling Kuo,Cheng-Hsun Chiu,Chih-Ho Lai
Pneumococcus is one of the most common human airway pathogens that causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM2.5) is known to significantly contribute to respiratory diseases. PM2.5-induced airway inflammation may decrease innate immune defenses against bacterial infection. However, there is currently limited information available
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Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality? Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-08-04 Siri A N Holme,Torben Sigsgaard,Jørn A Holme,Gitte Juel Holst
Exposure to air pollution has been associated with adverse effects on human health, and ultimately increased morbidity and mortality. This is predominantly due to hazardous effects on the cardiovascular system. Exposure to particulate matter (PM) is considered to be responsible for the most severe effects. Here we summarize current knowledge from existing epidemiological, clinical and animal studies
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Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-07-25 Irini M Dijkhoff,Barbara Drasler,Bedia Begum Karakocak,Alke Petri-Fink,Giuseppe Valacchi,Marc Eeman,Barbara Rothen-Rutishauser
Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles. To date, most of the research studies did focus on the adverse effects of
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Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-07-17 Min Beom Heo,Minjeong Kwak,Kyu Sup An,Hye Jin Kim,Hyeon Yeol Ryu,So Min Lee,Kyung Seuk Song,In Young Kim,Ji-Hwan Kwon,Tae Geol Lee
Nanotechnology is indispensable to many different applications. Although nanoparticles have been widely used in, for example, cosmetics, sunscreen, food packaging, and medications, they may pose human safety risks associated with nanotoxicity. Thus, toxicity testing of nanoparticles is essential to assess the relative health risks associated with consumer exposure. In this study, we identified the
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Comment on Saber et al. (2019), "Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation". Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-07-16 Kevin E Driscoll,Paul A Borm,Ishrat Chaudhuri,Len Levy,Mei Yong,David Warheit,Robert McCunney,Günter Oberdörster
In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to the Editor we discuss these inaccuracies to correct the scientific record. When the
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A response to the letter to the editor by Driscoll et al. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-07-16 Anne T Saber,Sarah S Poulsen,Niels Hadrup,Nicklas R Jacobsen,Ulla Vogel
In response to the Letter to the Editor by Kevin Driscoll et al., we certainly agree that particle clearance halftimes are increased with increasing lung burden in rats, hamsters and mice, whereas complete inhibition of particle clearance has only been observed in rats, and only at high particle concentrations (50 mg/m3). Where we disagree with Kevin Driscoll and colleagues, is on the implications
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Recent insights on indirect mechanisms in developmental toxicity of nanomaterials. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-07-11 Battuja Batbajar Dugershaw,Leonie Aengenheister,Signe Schmidt Kjølner Hansen,Karin Sørig Hougaard,Tina Buerki-Thurnherr
Epidemiological and animal studies provide compelling indications that environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal development and offspring health later in life. Understanding the origin and mechanisms underlying NM-induced developmental toxicity will be a cornerstone in the protection of sensitive populations and the design of safe and sustainable nanotechnology
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Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-07-11 Tianshu Wu,Xue Liang,Xi Liu,Yimeng Li,Yutong Wang,Lu Kong,Meng Tang
Graphene quantum dots (GQDs) provide a bright prospect in the biomedical application because they contain low-toxic compounds and promise imaging of deep tissues and tiny vascular structures. However, the biosafety of this novel QDs has not been thoroughly evaluated, especially in the central nervous system (CNS). The microarray analysis provides a hint that nitrogen-doped GQDs (N-GQDs) exposure could
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Toxicity of particles emitted by fireworks. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-07-02 Christina Hickey,Christopher Gordon,Karen Galdanes,Martin Blaustein,Lori Horton,Steven Chillrud,James Ross,Lital Yinon,Lung Chi Chen,Terry Gordon
Particle matter (PM) has been associated with increased morbidity and mortality rates across the world. This study was designed to test the hypotheses that pyrotechnic firework displays introduce significant amounts of toxic metals into the atmosphere and are hazardous to human health. Size-selective emissions from 10 different fireworks displays were collected during particle generation in a dynamic
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Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-07-01 Bethany Sanchez,Xixi Zhou,Amy S Gardiner,Guy Herbert,Selita Lucas,Masako Morishita,James G Wagner,Ryan Lewandowski,Jack R Harkema,Chris Shuey,Matthew J Campen,Katherine E Zychowski
Commercial uranium mining on the Navajo Nation has subjected communities on tribal lands in the Southwestern United States to exposures from residual environmental contamination. Vascular health effects from these ongoing exposures are an active area of study. There is an association between residential mine-site proximity and circulating biomarkers in residents, however, the contribution of mine-site
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Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-15 Tuukka Ihantola,Sebastiano Di Bucchianico,Mikko Happo,Mika Ihalainen,Oskari Uski,Stefanie Bauer,Kari Kuuspalo,Olli Sippula,Jarkko Tissari,Sebastian Oeder,Anni Hartikainen,Teemu J Rönkkö,Maria-Viola Martikainen,Kati Huttunen,Petra Vartiainen,Heikki Suhonen,Miika Kortelainen,Heikki Lamberg,Ari Leskinen,Martin Sklorz,Bernhard Michalke,Marco Dilger,Carsten Weiss,Gunnar Dittmar,Johannes Beckers,Martin Irmler
Wood combustion emissions have been studied previously either by in vitro or in vivo models using collected particles, yet most studies have neglected gaseous compounds. Furthermore, a more accurate and holistic view of the toxicity of aerosols can be gained with parallel in vitro and in vivo studies using direct exposure methods. Moreover, modern exposure techniques such as air-liquid interface (ALI)
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Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-11 Christine Coméra,Christel Cartier,Eric Gaultier,Olivier Catrice,Quentin Panouille,Sarah El Hamdi,Kristof Tirez,Inge Nelissen,Vassilia Théodorou,Eric Houdeau
Food-grade TiO2 (E171 in the EU) is widely used as a coloring agent in foodstuffs, including sweets. Chronic dietary exposure raises concerns for human health due to proinflammatory properties and the ability to induce and promote preneoplastic lesions in the rodent gut. Characterization of intestinal TiO2 uptake is essential for assessing the health risk in humans. We studied in vivo the gut absorption
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Oxygenated polycyclic aromatic hydrocarbons from ambient particulate matter induce electrophysiological instability in cardiomyocytes. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-11 Sujin Ju,Leejin Lim,Han-Yi Jiao,Seok Choi,Jae Yeoul Jun,Young-Jae Ki,Dong-Hyun Choi,Ji Yi Lee,Heesang Song
Epidemiologic studies have suggested that elevated concentrations of particulate matter (PM) are strongly associated with an increased risk of developing cardiovascular diseases, including arrhythmia. However, the cellular and molecular mechanisms by which PM exposure causes arrhythmia and the component that is mainly responsible for this adverse effect remains to be established. In this study, the
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The plastic brain: neurotoxicity of micro- and nanoplastics. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-08 Minne Prüst,Jonelle Meijer,Remco H S Westerink
Given the global abundance and environmental persistence, exposure of humans and (aquatic) animals to micro- and nanoplastics is unavoidable. Current evidence indicates that micro- and nanoplastics can be taken up by aquatic organism as well as by mammals. Upon uptake, micro- and nanoplastics can reach the brain, although there is limited information regarding the number of particles that reaches the
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Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-08 Mingxiang Wang,Jin Li,Shunni Dong,Xiaobo Cai,Aili Simaiti,Xin Yang,Xinqiang Zhu,Jianhong Luo,Lin-Hua Jiang,Binyang Du,Peilin Yu,Wei Yang
Wide applications of nanoparticles (NPs) have raised increasing concerns about safety to humans. Oxidative stress and inflammation are extensively investigated as mechanisms for NPs-induced toxicity. Autophagy and lysosomal dysfunction are emerging molecular mechanisms. Inhalation is one of the main pathways of exposing humans to NPs, which has been reported to induce severe pulmonary inflammation
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Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-05 Daochuan Li,Shen Chen,Qiong Li,Liping Chen,Haiyan Zhang,Huiyao Li,Dianke Yu,Rong Zhang,Yujie Niu,Shaoyou Lu,Lizhu Ye,Xiaowen Zeng,Guanghui Dong,Rui Chen,Michael Aschner,Yuxin Zheng,Wen Chen
Caloric restriction (CR) is known to improve health and extend lifespan in human beings. The effects of CR on adverse health outcomes in response to particulate matter (PM) exposure and the underlying mechanisms have yet to be defined. Male C57BL/6 J mice were fed with a CR diet or ad libitum (AL) and exposed to PM for 4 weeks in a real-ambient PM exposure system located at Shijiazhuang, China, with
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Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-05 Wolfgang G Kreyling,Uwe Holzwarth,Stephanie Hirn,Carsten Schleh,Alexander Wenk,Martin Schäffler,Nadine Haberl,Neil Gibson
There is a steadily increasing quantity of silver nanoparticles (AgNP) produced for numerous industrial, medicinal and private purposes, leading to an increased risk of inhalation exposure for both professionals and consumers. Particle inhalation can result in inflammatory and allergic responses, and there are concerns about other negative health effects from either acute or chronic low-dose exposure
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Analysis of particles from hamster lungs following pulmonary talc exposures: implications for pathogenicity. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-04 Erika Sato,Sandra A McDonald,Yuwei Fan,Shaina Peterson,Joseph D Brain,John J Godleski
Talc, a hydrous magnesium silicate, often used for genital hygiene purposes, is associated with ovarian carcinoma in case-control studies. Its potential to cause inflammation, injury, and functional changes in cells has been described. A complication of such studies is that talc preparations may be contaminated with other materials. A previous study by (Beck et al. Toxicol Appl Pharmacol 87:222-34
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Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-01 Bruno Lamas,Natalia Martins Breyner,Eric Houdeau
In food toxicology, there is growing interest in studying the impacts of foodborne nanoparticles (NPs, originating from food additives, food supplements or food packaging) on the intestinal microbiome due to the important and complex physiological roles of these microbial communities in host health. Biocidal activities, as described over recent years for most inorganic and metal NPs, could favour chronic
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Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-06-01 Sweelin Chew,Riikka Lampinen,Liudmila Saveleva,Paula Korhonen,Nikita Mikhailov,Alexandra Grubman,Jose M Polo,Trevor Wilson,Mika Komppula,Teemu Rönkkö,Cheng Gu,Alan Mackay-Sim,Tarja Malm,Anthony R White,Pasi Jalava,Katja M Kanninen
The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in the last decade. Oxidative stress and inflammation are key consequences of exposure to PM although little is known of the exact mechanism. The association of PM exposure with deteriorating brain health is speculated to be
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Toxicological evaluation of exhaust emissions from light-duty vehicles using different fuel alternatives in sub-freezing conditions. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-05-27 Henri Hakkarainen,Päivi Aakko-Saksa,Maija Sainio,Tuukka Ihantola,Teemu J Rönkkö,Päivi Koponen,Topi Rönkkö,Pasi I Jalava
Emissions from road traffic are under constant discussion since they pose a major threat to human health despite the increasingly strict emission targets and regulations. Although the new passenger car regulations have been very effective in reducing the particulate matter (PM) emissions, the aged car fleet in some EU countries remains a substantial source of PM emissions. Moreover, toxicity of PM
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Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-05-25 Sabina Halappanavar,Sybille van den Brule,Penny Nymark,Laurent Gaté,Carole Seidel,Sarah Valentino,Vadim Zhernovkov,Pernille Høgh Danielsen,Andrea De Vizcaya,Henrik Wolff,Tobias Stöger,Andrey Boyadziev,Sarah Søs Poulsen,Jorid Birkelund Sørli,Ulla Vogel
Toxicity testing and regulation of advanced materials at the nanoscale, i.e. nanosafety, is challenged by the growing number of nanomaterials and their property variants requiring assessment for potential human health impacts. The existing animal-reliant toxicity testing tools are onerous in terms of time and resources and are less and less in line with the international effort to reduce animal experiments
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Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-05-07 Omar Lozano,Christian Silva-Platas,Héctor Chapoy-Villanueva,Baruc E Pérez,Jarmon G Lees,Chrishan J A Ramachandra,Flavio F Contreras-Torres,Anay Lázaro-Alfaro,Estefanía Luna-Figueroa,Judith Bernal-Ramírez,Aldemar Gordillo-Galeano,Alfredo Benitez,Yuriana Oropeza-Almazán,Elena C Castillo,Poh Ling Koh,Derek J Hausenloy,Shiang Y Lim,Gerardo García-Rivas
Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related to abnormal calcium handling and energetic failure in cardiomyocytes. Moreover, the precise mechanisms underlying this energetic debacle remain unclear. In order to elucidate
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Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-04-22 Ran Li,Qing Sun,Sin Man Lam,Rucheng Chen,Junyao Zhu,Weijia Gu,Lu Zhang,He Tian,Kezhong Zhang,Lung-Chi Chen,Qinghua Sun,Guanghou Shui,Cuiqing Liu
Emerging evidence supports ambient fine particulate matter (PM2.5) exposure is associated with insulin resistance (IR) and hepatic lipid accumulation. In this study, we aimed to evaluate the sex-dependent vulnerability in response to PM2.5 exposure and investigate the underlying mechanism by which PM2.5 modulates hepatic lipid metabolism. Both male and female C57BL/6 mice were randomly assigned to
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Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-04-21 Tonje Skuland,Marit Låg,Arno C Gutleb,Bendik C Brinchmann,Tommaso Serchi,Johan Øvrevik,Jørn A Holme,Magne Refsnes
Silica nanoparticles (SiNPs) are among the most widely manufactured and used nanoparticles. Concerns about potential health effects of SiNPs have therefore risen. Using a 3D tri-culture model of the alveolar lung barrier we examined effects of exposure to SiNPs (Si10) and crystalline silica (quartz; Min-U-Sil) in the apical compartment consisting of human alveolar epithelial A549 cells and THP-1-derived
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Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation. Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-03-23 De-Ping Wang,Zhao-Jun Wang,Rong Zhao,Cai-Xia Lin,Qian-Yu Sun,Cai-Ping Yan,Xin Zhou,Ji-Min Cao
The growing use of silica nanoparticles (SiNPs) in many fields raises human toxicity concerns. We studied the toxicity of SiNP-20 (particle diameter 20 nm) and SiNP-100 (100 nm) and the underlying mechanisms with a focus on the endothelium both in vitro and in vivo. The study was conducted in cultured human umbilical vein endothelial cells (HUVECs) and adult female Balb/c mice using several techniques
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Combination of the BeWo b30 placental transport model and the embryonic stem cell test to assess the potential developmental toxicity of silver nanoparticles Part. Fibre Toxicol. (IF 7.546) Pub Date : 2020-03-10 Ashraf Abdelkhaliq; Meike van der Zande; Ruud J. B. Peters; Hans Bouwmeester
Silver nanoparticles (AgNPs) are used extensively in various consumer products because of their antimicrobial potential. This requires insight in their potential hazards and risks including adverse effects during pregnancy on the developing fetus. Using a combination of the BeWo b30 placental transport model and the mouse embryonic stem cell test (EST), we investigated the capability of pristine AgNPs