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  • Exploring Perinatal Asphyxia by Metabolomics
    Metabolites (IF 3.303) Pub Date : 2020-04-04
    Emanuela Locci; Giovanni Bazzano; Roberto Demontis; Alberto Chighine; Vassilios Fanos; Ernesto d’Aloja

    Brain damage related to perinatal asphyxia is the second cause of neuro-disability worldwide. Its incidence was estimated in 2010 as 8.5 cases per 1000 live births worldwide, with no further recent improvement even in more industrialized countries. If so, hypoxic-ischemic encephalopathy is still an issue of global health concern. It is thought that a consistent number of cases may be avoided, and its

    更新日期:2020-04-06
  • Metabolomics Benefits from Orbitrap GC–MS—Comparison of Low- and High-Resolution GC–MS
    Metabolites (IF 3.303) Pub Date : 2020-04-04
    Daniel Stettin; Remington X. Poulin; Georg Pohnert

    The development of improved mass spectrometers and supporting computational tools is expected to enable the rapid annotation of whole metabolomes. Essential for the progress is the identification of strengths and weaknesses of novel instrumentation in direct comparison to previous instruments. Orbitrap liquid chromatography (LC)–mass spectrometry (MS) technology is now widely in use, while Orbitrap

    更新日期:2020-04-06
  • Microbiome-Metabolome Signature of Acute Kidney Injury
    Metabolites (IF 3.303) Pub Date : 2020-04-04
    Nadezda V. Andrianova; Vasily A. Popkov; Natalia S. Klimenko; Alexander V. Tyakht; Galina V. Baydakova; Olga Y. Frolova; Ljubava D. Zorova; Irina B. Pevzner; Dmitry B. Zorov; Egor Y. Plotnikov

    Intestinal microbiota play a considerable role in the host’s organism, broadly affecting its organs and tissues. The kidney can also be the target of the microbiome and its metabolites (especially short-chain fatty acids), which can influence renal tissue, both by direct action and through modulation of the immune response. This impact is crucial, especially during kidney injury, because the modulation

    更新日期:2020-04-06
  • Delta-Integration of Single Gene Shapes the Whole Metabolomic Short-Term Response to Ethanol of Recombinant Saccharomyces cerevisiae Strains
    Metabolites (IF 3.303) Pub Date : 2020-04-03
    Laura Corte; Luca Roscini; Debora Casagrande Pierantoni; Roberto Maria Pellegrino; Carla Emiliani; Marina Basaglia; Lorenzo Favaro; Sergio Casella; Gianluigi Cardinali

    In yeast engineering, metabolic burden is often linked to the reprogramming of resources from regular cellular activities to guarantee recombinant protein(s) production. Therefore, growth parameters can be significantly influenced. Two recombinant strains, previously developed by the multiple δ-integration of a glucoamylase in the industrial Saccharomyces cerevisiae 27P, did not display any detectable

    更新日期:2020-04-03
  • A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis
    Metabolites (IF 3.303) Pub Date : 2020-04-02
    Marc R. McCann; Cora E. McHugh; Maggie Kirby; Theodore S. Jennaro; Alan E. Jones; Kathleen A. Stringer; Michael A. Puskarich

    Background: Sepsis-induced alterations in mitochondrial function contribute to organ dysfunction and mortality. Measuring mitochondrial function in vital organs is neither feasible nor practical, highlighting the need for non-invasive approaches. Mitochondrial function may be reflected in the concentrations of metabolites found in platelets and whole blood (WB) samples. We proposed to use these as

    更新日期:2020-04-03
  • Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise
    Metabolites (IF 3.303) Pub Date : 2020-04-01
    Robert Ringseis; Denise K. Gessner; Anna M. Beer; Yvonne Albrecht; Gaiping Wen; Erika Most; Karsten Krüger; Klaus Eder

    Recently, administration of nicotinic acid (NA) at a pharmacological dose was found to induce a similar change in the muscle´s contractile and metabolic phenotype as observed in response to endurance exercise. Thus, the hypothesis was tested that combined NA administration and endurance exercise promotes the adaptation of muscle to regular exercise and improves the endurance performance to a greater

    更新日期:2020-04-01
  • Component Profiling of Soy-Sauce-Like Seasoning Produced from Different Raw Materials
    Metabolites (IF 3.303) Pub Date : 2020-04-01
    Tomoyuki Yamana; Moyu Taniguchi; Takeharu Nakahara; Yusuke Ito; Natsuki Okochi; Sastia Prama Putri; Eiichiro Fukusaki

    Soy sauce is a traditional Japanese umami seasoning commonly made from soybeans, wheat, and salt water. Soy-sauce-like seasoning, made from other raw materials, such as rice and peas, has recently been developed. However, differences in the taste of soy-sauce-like seasoning, depending on the raw materials, have not been evaluated. Component profiling based on GC/MS combined with a paired comparison

    更新日期:2020-04-01
  • Synthesis and Biological Evaluation of Imidazo[2 ,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors
    Metabolites (IF 3.303) Pub Date : 2020-03-31
    Kesari Lakshmi Manasa; Sravya Pujitha; Aaftaab Sethi; Arifuddin Mohammed; Mallika Alvala; Andrea Angeli; Claudiu T. Supuran

    A novel series of imidazo[2,1-b]thiazole-sulfonyl piperazine conjugates (9aa-ee) has been synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isozyme hCA I, II and trans-membrane tumor-associated isoform hCA IX and hCA XII, taking acetazolamide (AAZ) as standard drug, using a stopped flow CO2 hydrase assay. The results revealed that

    更新日期:2020-03-31
  • “notame”: Workflow for Non-Targeted LC–MS Metabolic Profiling
    Metabolites (IF 3.303) Pub Date : 2020-03-31
    Anton Klåvus; Marietta Kokla; Stefania Noerman; Ville M. Koistinen; Marjo Tuomainen; Iman Zarei; Topi Meuronen; Merja R. Häkkinen; Soile Rummukainen; Ambrin Farizah Babu; Taisa Sallinen; Olli Kärkkäinen; Jussi Paananen; David Broadhurst; Carl Brunius; Kati Hanhineva

    Metabolomics analysis generates vast arrays of data, necessitating comprehensive workflows involving expertise in analytics, biochemistry and bioinformatics in order to provide coherent and high-quality data that enable discovery of robust and biologically significant metabolic findings. In this protocol article, we introduce notame, an analytical workflow for non-targeted metabolic profiling approaches

    更新日期:2020-03-31
  • GC-MS Based Metabolite Profiling to Monitor Ripening-Specific Metabolites in Pineapple (Ananas comosus)
    Metabolites (IF 3.303) Pub Date : 2020-03-31
    Muhammad Maulana Malikul Ikram; Sobir Ridwani; Sastia Prama Putri; Eiichiro Fukusaki

    Pineapple is one of the most cultivated tropical, non-climacteric fruits in the world due to its high market value and production volume. Since non-climacteric fruits do not ripen after harvest, the ripening stage at the time of harvest is an important factor that determines sensory quality and shelf life. The objective of this research was to investigate metabolite changes in the pineapple ripening

    更新日期:2020-03-31
  • Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year
    Metabolites (IF 3.303) Pub Date : 2020-03-30
    Yu Ra Lee; Eunju Im; Haksoon Kim; Bark Lynn Lew; Woo-Young Sim; Jeongae Lee; Han Bin Oh; Ki Jung Paeng; Jongki Hong; Bong Chul Chung

    Male pattern baldness (MPB) has been associated with dihydrotestosterone (DHT) expression. Finasteride treats MPB by inhibiting 5-alpha reductase and blocking DHT production. In this study, we aimed to identify metabolic differences in urinary metabolomics profiles between MPB patients after a one-year treatment with finasteride and healthy controls. Untargeted and targeted metabolomics profiling was

    更新日期:2020-03-30
  • Proteobacteria Overgrowth and Butyrate-Producing Taxa Depletion in the Gut Microbiota of Glycogen Storage Disease Type 1 Patients
    Metabolites (IF 3.303) Pub Date : 2020-03-30
    Camilla Ceccarani; Giulia Bassanini; Chiara Montanari; Maria Cristina Casiraghi; Emerenziana Ottaviano; Giulia Morace; Giacomo Biasucci; Sabrina Paci; Elisa Borghi; Elvira Verduci

    A life-long dietary intervention can affect the substrates’ availability for gut fermentation in metabolic diseases such as the glycogen-storage diseases (GSD). Besides drug consumption, the main treatment of types GSD-Ia and Ib to prevent metabolic complications is a specific diet with definite nutrient intakes. In order to evaluate how deeply this dietary treatment affects gut bacteria, we compared

    更新日期:2020-03-30
  • Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production
    Metabolites (IF 3.303) Pub Date : 2020-03-30
    Claudia Beltran; Rosario Pardo; Diana Bou-Teen; Marisol Ruiz-Meana; Josep A. Villena; Ignacio Ferreira-González; Ignasi Barba

    After myocardial ischemia-reperfusion, fatty acid oxidation shows fast recovery while glucose oxidation rates remain depressed. A metabolic shift aimed at increasing glucose oxidation has shown to be beneficial in models of myocardial ischemia-reperfusion. However, strategies aimed at increasing glucose consumption in the clinic have provided mixed results and have not yet reached routine clinical

    更新日期:2020-03-30
  • Suggestions for Standardized Identifiers for Fatty Acyl Compounds in Genome Scale Metabolic Models and Their Application to the WormJam Caenorhabditis elegans Model
    Metabolites (IF 3.303) Pub Date : 2020-03-28
    Michael Witting

    Genome scale metabolic models (GSMs) are a representation of the current knowledge on the metabolism of a given organism or superorganism. They group metabolites, genes, enzymes and reactions together to form a mathematical model and representation that can be used to analyze metabolic networks in silico or used for analysis of omics data. Beside correct mass and charge balance, correct structural

    更新日期:2020-03-28
  • The ABRF Metabolomics Research Group 2016 Exploratory Study: Investigation of Data Analysis Methods for Untargeted Metabolomics
    Metabolites (IF 3.303) Pub Date : 2020-03-27
    Christoph W. Turck; Tytus D Mak; Maryam Goudarzi; Reza M Salek; Amrita K Cheema

    Lack of standardized applications of bioinformatics and statistical approaches for pre- and postprocessing of global metabolomic profiling data sets collected using high-resolution mass spectrometry platforms remains an inadequately addressed issue in the field. Several publications now recognize that data analysis outcome variability is caused by different data treatment approaches. Yet, there is

    更新日期:2020-03-27
  • Current Concepts in Pharmacometabolomics, Biomarker Discovery, and Precision Medicine
    Metabolites (IF 3.303) Pub Date : 2020-03-27
    Richard D. Beger; Michael A Schmidt; Rima Kaddurah-Daouk

    Pharmacometabolomics (PMx) studies use information contained in metabolic profiles (or metabolome) to inform about how a subject will respond to drug treatment. Genome, gut microbiome, sex, nutrition, age, stress, health status, and other factors can impact the metabolic profile of an individual. Some of these factors are known to influence the individual response to pharmaceutical compounds. An individual’s

    更新日期:2020-03-27
  • Bile Acid Profile and its Changes in Response to Cefoperazone Treatment in MR1 Deficient Mice
    Metabolites (IF 3.303) Pub Date : 2020-03-26
    Jinchun Sun; Zhijun Cao; Ashley D. Smith; Paul E. Carlson; Michael Coryell; Huizhong Chen; Richard D. Beger

    Mucosal associated invariant T-cells (MAIT cells) are activated following recognition of bacterial antigens (riboflavin intermediates) presented on major histocompatibility complex class I-related molecule (MR1). Our previous study showed that MR1-/- knock-out (KO) mice (lacking MAIT cells) harbor a unique microbiota that is resistant to antibiotic disruption and Clostridioides difficile colonization

    更新日期:2020-03-27
  • Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC–MS Metabolomics
    Metabolites (IF 3.303) Pub Date : 2020-03-26
    Isabel Ten-Doménech; Teresa Martínez-Sena; Marta Moreno-Torres; Juan Daniel Sanjuan-Herráez; José V. Castell; Anna Parra-Llorca; Máximo Vento; Guillermo Quintás; Julia Kuligowski

    One of the most widely used strategies for metabolite annotation in untargeted LCMS is based on the analysis of MSn spectra acquired using data-dependent acquisition (DDA), where precursor ions are sequentially selected from MS scans based on user-selected criteria. However, the number of MSn spectra that can be acquired during a chromatogram is limited and a trade-off between analytical speed, sensitivity

    更新日期:2020-03-27
  • Enzyme Assembly for Compartmentalized Metabolic Flux Control
    Metabolites (IF 3.303) Pub Date : 2020-03-26
    Xueqin Lv; Shixiu Cui; Yang Gu; Jianghua Li; Guocheng Du; Long Liu

    Enzyme assembly by ligand binding or physically sequestrating enzymes, substrates, or metabolites into isolated compartments can bring key molecules closer to enhance the flux of a metabolic pathway. The emergence of enzyme assembly has provided both opportunities and challenges for metabolic engineering. At present, with the development of synthetic biology and systems biology, a variety of enzyme

    更新日期:2020-03-27
  • Identifying Protein–metabolite Networks Associated with COPD Phenotypes
    Metabolites (IF 3.303) Pub Date : 2020-03-25
    Emily Mastej; Lucas Gillenwater; Yonghua Zhuang; Katherine A. Pratte; Russell P. Bowler; Katerina Kechris

    Chronic obstructive pulmonary disease (COPD) is a disease in which airflow obstruction in the lung makes it difficult for patients to breathe. Although COPD occurs predominantly in smokers, there are still deficits in our understanding of the additional risk factors in smokers. To gain a deeper understanding of the COPD molecular signatures, we used Sparse Multiple Canonical Correlation Network (SmCCNet)

    更新日期:2020-03-26
  • An Integrative Approach to Assessing Diet–Cancer Relationships
    Metabolites (IF 3.303) Pub Date : 2020-03-25
    Rachel Murphy

    The relationship between diet and cancer is often viewed with skepticism by the public and health professionals, despite a considerable body of evidence and general consistency in recommendations over the past decades. A systems biology approach which integrates ‘omics’ data including metabolomics, genetics, metagenomics, transcriptomics and proteomics holds promise for developing a better understanding

    更新日期:2020-03-26
  • Deriving Lipid Classification Based on Molecular Formulas
    Metabolites (IF 3.303) Pub Date : 2020-03-24
    Joshua M. Mitchell; Robert M. Flight; Hunter N.B. Moseley

    Despite instrument and algorithmic improvements, the untargeted and accurate assignment of metabolites remains an unsolved problem in metabolomics. New assignment methods such as our SMIRFE algorithm can assign elemental molecular formulas to observed spectral features in a highly untargeted manner without orthogonal information from tandem MS or chromatography. However, for many lipidomics applications

    更新日期:2020-03-24
  • Comparative Metabolomics and Molecular Phylogenetics of Melon (Cucumis melo, Cucurbitaceae) Biodiversity
    Metabolites (IF 3.303) Pub Date : 2020-03-24
    Annick Moing; J. William Allwood; Asaph Aharoni; John Baker; Michael H. Beale; Shifra Ben-Dor; Benoît Biais; Federico Brigante; Yosef Burger; Catherine Deborde; Alexander Erban; Adi Faigenboim; Amit Gur; Royston Goodacre; Thomas H. Hansen; Daniel Jacob; Nurit Katzir; Joachim Kopka; Efraim Lewinsohn; Mickael Maucourt; Sagit Meir; Sonia Miller; Roland Mumm; Elad Oren; Harry S. Paris; Ilana Rogachev;

    The broad variability of Cucumis melo (melon, Cucurbitaceae) presents a challenge to conventional classification and organization within the species. To shed further light on the infraspecific relationships within C. melo, we compared genotypic and metabolomic similarities among 44 accessions representative of most of the cultivar-groups. Genotyping-by-sequencing (GBS) provided over 20,000 single-nucleotide

    更新日期:2020-03-24
  • The Application of Metabolomics to Probiotic and Prebiotic Interventions in Human Clinical Studies
    Metabolites (IF 3.303) Pub Date : 2020-03-24
    Thomas M. O’Connell

    There is an ever-increasing appreciation for our gut microbiota that plays a crucial role in the maintenance of health, as well as the development of disease. Probiotics are live bacteria that are consumed to increase the population of beneficial bacteria and prebiotics are dietary substrates intended to promote the propagation of beneficial bacteria. In order to optimize the use of probiotics and

    更新日期:2020-03-24
  • Extensive Profiling of Polyphenols from two Trollius Species Using a Combination of Untargeted and Targeted Approaches
    Metabolites (IF 3.303) Pub Date : 2020-03-23
    He Tian; Zhiyang Zhou; Guanghou Shui; Sin Man Lam

    Various species of globeflowers, belonging to the genus Trollius, have been extensively used in traditional Chinese medicine due to their anti-inflammatory, antimicrobial, and antiviral properties, which are mainly attributed to their high polyphenol content. Differences in polyphenol composition, and abundances, will lead to varying treatment efficacies of globeflowers. Herein, we employ a combination

    更新日期:2020-03-24
  • Robust Moiety Model Selection Using Mass Spectrometry Measured Isotopologues
    Metabolites (IF 3.303) Pub Date : 2020-03-21
    Huan Jin; Hunter N.B. Moseley

    Stable isotope resolved metabolomics (SIRM) experiments use stable isotope tracers to provide superior metabolomics datasets for metabolic flux analysis and metabolic modeling. Since assumptions of model correctness can seriously compromise interpretation of metabolic flux results, we have developed a metabolic modeling software package specifically designed for moiety model comparison and selection

    更新日期:2020-03-22
  • Nematode-Trapping Fungi Produce Diverse Metabolites during Predator–Prey Interaction
    Metabolites (IF 3.303) Pub Date : 2020-03-20
    Ting-Hao Kuo; Ching-Ting Yang; Hsin-Yuan Chang; Yen-Ping Hsueh; Cheng-Chih Hsu

    Nematode-trapping fungi are natural antagonists of nematodes. These predatory fungi are capable of switching their lifestyle from a saprophytic to predatory stage in the presence of nematodes by developing specialized trapping devices to capture and consume nematodes. The biochemical mechanisms of such predator–prey interaction have become increasingly studied given the potential application of nematode-trapping

    更新日期:2020-03-21
  • Estrogen Receptor beta (ERβ) Regulation of Lipid Homeostasis—Does Sex Matter?
    Metabolites (IF 3.303) Pub Date : 2020-03-20
    Christina Savva; Marion Korach-André

    In this communication, we aim to summarize the role of estrogen receptor beta (ERβ) in lipid metabolism in the main metabolic organs with a special focus on sex differences. The action of ERβ is tissue-specific and acts in a sex-dependent manner, emphasizing the necessity of developing sex- and tissue-selective targeting drugs in the future.

    更新日期:2020-03-21
  • Protective Role of Vitamin D in Renal Tubulopathies
    Metabolites (IF 3.303) Pub Date : 2020-03-19
    Guido Gembillo; Valeria Cernaro; Rossella Siligato; Francesco Curreri; Antonino Catalano; Domenico Santoro

    Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3. Patients with renal impairment or tubular injury often suffer from chronic inflammation. This alteration comes from oxidative stress, acidosis, decreased clearance of inflammatory cytokines and stimulation of inflammatory factors. The

    更新日期:2020-03-20
  • Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits
    Metabolites (IF 3.303) Pub Date : 2020-03-19
    Vuanghao Lim; Sara Ghorbani Gorji; Venea Dara Daygon; Melissa Fitzgerald

    Selected Australian native fruits such as Davidson’s plum, finger lime and native pepperberry have been reported to demonstrate potent antioxidant activity. However, comprehensive metabolite profiling of these fruits is limited, therefore the compounds responsible are unknown, and further, the compounds of nutritional value in these native fruits are yet to be described. In this study, untargeted and

    更新日期:2020-03-20
  • 16HBE Cell Lipid Mediator Responses to Mono and Co-Infections with Respiratory Pathogens
    Metabolites (IF 3.303) Pub Date : 2020-03-18
    Daniel Schultz; Surabhi Surabhi; Nicolas Stelling; Michael Rothe; KoInfekt Study Group; Karen Methling; Sven Hammerschmidt; Nikolai Siemens; Michael Lalk

    Respiratory tract infections are a global health problem. The main causative agents of these infections are influenza A virus (IAV), Staphylococcus aureus (S. aureus), and Streptococcus pneumoniae (S. pneumoniae). Major research focuses on genetics and immune responses in these infections. Eicosanoids and other oxylipins are host-derived lipid mediators that play an important role in the activation

    更新日期:2020-03-19
  • Discrimination of Adzuki Bean (Vigna angularis) Geographical Origin by Targeted and Non-Targeted Metabolite Profiling with Gas Chromatography Time-of-Flight Mass Spectrometry
    Metabolites (IF 3.303) Pub Date : 2020-03-17
    Tae Jin Kim; Jeong Gon Park; Soon Kil Ahn; Kil Won Kim; Jaehyuk Choi; Hyun Young Kim; Sun-Hwa Ha; Woo Duck Seo; Jae Kwang Kim

    As international food trade increases, consumers are becoming increasingly interested in food safety and authenticity, which are linked to geographical origin. Adzuki beans (Vigna angularis) are cultivated worldwide, but there are no tools for accurately discriminating their geographical origin. Thus, our study aims to develop a method for discriminating the geographical origin of adzuki beans through

    更新日期:2020-03-19
  • Compound Characterization and Metabolic Profile Elucidation after In Vitro Gastrointestinal and Hepatic Biotransformation of an Herniaria hirsuta Extract Using Unbiased Dynamic Metabolomic Data Analysis
    Metabolites (IF 3.303) Pub Date : 2020-03-16
    Laura Peeters; Anastasia Van der Auwera; Charlie Beirnaert; Sebastiaan Bijttebier; Kris Laukens; Luc Pieters; Nina Hermans; Kenn Foubert

    Herniaria hirsuta L. (Caryophyllaceae) is used for treatment of urinary stones and as a diuretic. Little is known about the active compounds and the mechanism of action. The phytochemical composition of H. hirsuta was comprehensively characterized using UHPLC-UV-HRMS (Ultrahigh-Performance Liquid Chromatography-Ultraviolet-High Resolution Mass Spectrometry) data. An in vitro gastrointestinal model

    更新日期:2020-03-16
  • Color Mutations Alter the Biochemical Composition in the San Marzano Tomato Fruit
    Metabolites (IF 3.303) Pub Date : 2020-03-15
    Gabriella Dono; Jose Luis Rambla; Sarah Frusciante; Antonio Granell; Gianfranco Diretto; Andrea Mazzucato

    San Marzano (SM) is a traditional Italian landrace characterized by red elongated fruits, originating in the province of Naples (Italy) and cultivated worldwide. Three mutations, yellow flesh (r), green flesh (gf) and colorless fruit epidermis (y) were introduced into SM by backcross and the resulting introgression lines (ILs) produced the expected yellow, brown and pink fruit variants. In addition

    更新日期:2020-03-16
  • Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes
    Metabolites (IF 3.303) Pub Date : 2020-03-14
    José David Piñeiro-Ramos; Antonio Núñez-Ramiro; Roberto Llorens-Salvador; Anna Parra-Llorca; Ángel Sánchez-Illana; Guillermo Quintás; Nuria Boronat-González; Juan Martínez-Rodilla; Julia Kuligowski; Máximo Vento; The HYPOTOP Study Group

    Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling the detection of brain injury. Plasma samples of a cohort of 55 asphyxiated infants who evolved to moderate/severe HIE were collected between birth and

    更新日期:2020-03-16
  • Deciphering the Metabolic Pathways of Pitaya Peel after Postharvest Red Light Irradiation
    Metabolites (IF 3.303) Pub Date : 2020-03-14
    Qixian Wu; Huijun Gao; Zhengke Zhang; Taotao Li; Hongxia Qu; Yueming Jiang; Ze Yun

    Red light irradiation can effectively prolong the shelf-life of many fruit. However, little is known about red light-induced metabolite and enzyme activities. In this study, pitaya fruit was treated with 100 Lux red light for 24 h. Red light irradiation significantly attenuated the variation trend of senescence traits, such as the decrease of total soluble solid (TSS) and TSS/acidity (titratable acidity

    更新日期:2020-03-16
  • The Interrelations between Biological and Targeted Synthetic Agents Used in Inflammatory Joint Diseases, and Obesity or Body Composition
    Metabolites (IF 3.303) Pub Date : 2020-03-13
    Eric Toussirot

    Obesity is a comorbidity that plays a role in the development and severity of inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. The relationships between obesity and adipose tissue and the treatments given for inflammatory joint diseases are bidirectional. In fact, biological agents (bDMARDs) and targeted synthetic agents (tsDMARDs) may influence

    更新日期:2020-03-16
  • Antifungal Drugs
    Metabolites (IF 3.303) Pub Date : 2020-03-12
    Jiří Houšť; Jaroslav Spížek; Vladimír Havlíček

    We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein, and deoxyribonucleic acid biosynthesis, or sequestrate ergosterol. Their most severe side effects are hepatotoxicity, nephrotoxicity, and myelotoxicity. Whereas

    更新日期:2020-03-12
  • Intracellular Metabolites in Marine Microorganisms during an Experiment Evaluating Microbial Mortality
    Metabolites (IF 3.303) Pub Date : 2020-03-12
    Krista Longnecker; Elizabeth B. Kujawinski

    Metabolomics is a tool with immense potential for providing insight into the impact of biological processes on the environment. Here, we used metabolomics methods to characterize intracellular metabolites within marine microorganisms during a manipulation experiment that was designed to test the impact of two sources of microbial mortality, protozoan grazing and viral lysis. Intracellular metabolites

    更新日期:2020-03-12
  • Important Considerations for Sample Collection in Metabolomics Studies with a Special Focus on Applications to Liver Functions
    Metabolites (IF 3.303) Pub Date : 2020-03-12
    Lorraine Smith; Joran Villaret-Cazadamont; Sandrine P. Claus; Cécile Canlet; Hervé Guillou; Nicolas J. Cabaton; Sandrine Ellero-Simatos

    Metabolomics has found numerous applications in the study of liver metabolism in health and disease. Metabolomics studies can be conducted in a variety of biological matrices ranging from easily accessible biofluids such as urine, blood or feces, to organs, tissues or even cells. Sample collection and storage are critical steps for which standard operating procedures must be followed. Inappropriate

    更新日期:2020-03-12
  • Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Comparison of TCA Cycle Intermediates in Human Serum, Plasma, Kasumi-1 Cell and Murine Liver Tissue
    Metabolites (IF 3.303) Pub Date : 2020-03-12
    Ramji Rathod; Bharat Gajera; Kenneth Nazir; Janne Wallenius; Vidya Velagapudi

    The tricarboxylic acid (TCA) cycle is a central part of carbon and energy metabolism, also connecting to glycolysis, amino acid, and lipid metabolism. The quantitation of the TCA cycle intermediate within one method is lucrative due to the interest in central carbon metabolism profiling in cells and tissues. In addition, TCA cycle intermediates in serum have been discovered to correspond as biomarkers

    更新日期:2020-03-12
  • Evaluation of the Potential Allergenicity of Strawberries in Response to Different Farming Practices
    Metabolites (IF 3.303) Pub Date : 2020-03-12
    Mateusz Aninowski; Renata Kazimierczak; Ewelina Hallmann; Joanna Rachtan-Janicka; Elżbieta Fijoł-Adach; Beata Feledyn-Szewczyk; Iwona Majak; Joanna Leszczyńska

    Fruit allergies are a large problem today. Many consumers suffer from food allergies or intolerances. The method of food production has a major impact on its quality. In fruit and vegetable production, three different farming systems are mainly found: conventional, integrated pest management and organic production. The latter is considered the best in terms of fruits and vegetables safety and high

    更新日期:2020-03-12
  • Lipid Annotator: Towards Accurate Annotation in Non-Targeted Liquid Chromatography High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS) Lipidomics Using A Rapid and User-Friendly Software
    Metabolites (IF 3.303) Pub Date : 2020-03-12
    Jeremy P. Koelmel; Xiangdong Li; Sarah M. Stow; Mark J. Sartain; Adithya Murali; Robin Kemperman; Hiroshi Tsugawa; Mikiko Takahashi; Vasilis Vasiliou; John A. Bowden; Richard A. Yost; Timothy J. Garrett; Norton Kitagawa

    Lipidomics has great promise in various applications; however, a major bottleneck in lipidomics is the accurate and comprehensive annotation of high-resolution tandem mass spectral data. While the number of available lipidomics software has drastically increased over the past five years, the reduction of false positives and the realization of obtaining structurally accurate annotations remains a significant

    更新日期:2020-03-12
  • An Untargeted Metabolomics Approach to Investigate the Metabolic Effect of Beetroot Juice Supplementation in Fencers—A Preliminary Study
    Metabolites (IF 3.303) Pub Date : 2020-03-11
    Lucyna Kozlowska; Olga Mizera; Anna Mroz

    This study aimed at assessment of the long-term (4 weeks) metabolic effect of a diet with and without beetroot juice supplementation in fencers using the untargeted metabolomics method with the UPLC Q-TOF/MS system to carry out an analysis of urine samples. Ten women and 10 men underwent the cardiovascular fitness VO2max test at baseline—(B) and after two stages of implementation of the dietary recommendations—the

    更新日期:2020-03-12
  • A Metabolomics Analysis of Adiposity and Advanced Prostate Cancer Risk in the Health Professionals Follow-Up Study
    Metabolites (IF 3.303) Pub Date : 2020-03-10
    Barbra A. Dickerman; Ericka M. Ebot; Brian C. Healy; Kathryn M. Wilson; A. Heather Eliassen; Alberto Ascherio; Claire H. Pernar; Oana A. Zeleznik; Matthew G. Vander Heiden; Clary B. Clish; Edward Giovannucci; Lorelei A. Mucci

    Obesity is associated with a higher risk of advanced prostate cancer, but men with the same body mass index (BMI) may differ in their underlying metabolic health. Using metabolomics data from nested case-control studies in the Health Professionals Follow-Up Study, we calculated Pearson correlations between 165 circulating metabolites and three adiposity measures (BMI, waist circumference, and derived

    更新日期:2020-03-10
  • Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease–The Possible Role of an Abnormal Serum Fatty Acid Profile
    Metabolites (IF 3.303) Pub Date : 2020-03-08
    Justyna Korczyńska; Aleksandra Czumaj; Michał Chmielewski; Maciej Śledziński; Adriana Mika; Tomasz Śledziński

    Chronic kidney disease (CKD) is associated with an increased level of leptin and an abnormal fatty acid (FA) profile in the serum. However, there are no data on the associations between them, and the reason for increased serum levels in patients with CKD is not well elucidated. Recently, we found that a CKD-related abnormal FA profile caused significant changes in the expression of genes involved in

    更新日期:2020-03-09
  • Gut Microbial-Derived Metabolomics of Asthma
    Metabolites (IF 3.303) Pub Date : 2020-03-06
    Kathleen A. Lee-Sarwar; Jessica Lasky-Su; Rachel S. Kelly; Augusto A. Litonjua; Scott T. Weiss

    In this review, we discuss gut microbial-derived metabolites involved with the origins and pathophysiology of asthma, a chronic respiratory disease that is influenced by the microbiome. Although both gut and airway microbiomes may be important in asthma development, we focus here on the gut microbiome and metabolomic pathways involved in immune system ontogeny. Metabolite classes with existing evidence

    更新日期:2020-03-06
  • Metabolomics to Exploit the Primed Immune System of Tomato Fruit
    Metabolites (IF 3.303) Pub Date : 2020-03-06
    Estrella Luna; Amélie Flandin; Cédric Cassan; Sylvain Prigent; Chloé Chevanne; Camélia Feyrouse Kadiri; Yves Gibon; Pierre Pétriacq

    Tomato is a major crop suffering substantial yield losses from diseases, as fruit decay at a postharvest level can claim up to 50% of the total production worldwide. Due to the environmental risks of fungicides, there is an increasing interest in exploiting plant immunity through priming, which is an adaptive strategy that improves plant defensive capacity by stimulating induced mechanisms. Broad-spectrum

    更新日期:2020-03-06
  • Gas Chromatography–Mass Spectrometry-Based Metabolomic Analysis of Wagyu and Holstein Beef
    Metabolites (IF 3.303) Pub Date : 2020-03-06
    Tomoya Yamada; Mituru Kamiya; Mikito Higuchi

    Japanese Black cattle (Wagyu) beef is characterized by high intramuscular fat content and has a characteristic sweet taste. However, the chemical components for characterizing the sweet taste of Wagyu beef have been unclear. In this experiment, we conducted a metabolomic analysis of the longissimus muscle (sirloin) in Wagyu and Holstein cattle to determine the key components associated with beef taste

    更新日期:2020-03-06
  • An Integrated Multi-Disciplinary Perspectivefor Addressing Challenges of the Human Gut Microbiome
    Metabolites (IF 3.303) Pub Date : 2020-03-06
    Rohan M. Shah; Elizabeth J. McKenzie; Magda T. Rosin; Snehal R. Jadhav; Shakuntla V. Gondalia; Douglas Rosendale; David J. Beale

    Our understanding of the human gut microbiome has grown exponentially. Advances in genome sequencing technologies and metagenomics analysis have enabled researchers to study microbial communities and their potential function within the context of a range of human gut related diseases and disorders. However, up until recently, much of this research has focused on characterizing the gut microbiological

    更新日期:2020-03-06
  • Food Targeting: Determination of the Cocoa Shell Content (Theobroma cacao L.) in Cocoa Products by LC-QqQ-MS/MS
    Metabolites (IF 3.303) Pub Date : 2020-03-05
    Nicolas Cain; Christian Marji; Kristian von Wuthenau; Torben Segelke; Markus Fischer

    A targeted metabolomics LC-ESI-QqQ-MS/MS application for the determination of cocoa shell based on 15 non-polar key metabolites was developed, validated according to recognized guidelines, and used to predict the cocoa shell content in various cocoa products. For the cocoa shell prediction, different PLSR models based on different cocoa shell calibration series were developed and their suitability

    更新日期:2020-03-06
  • Anion Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora
    Metabolites (IF 3.303) Pub Date : 2020-03-05
    Daniela Vullo; Ronny Lehneck; William A. Donald; Stefanie Pöggeler; Claudiu T. Supuran

    CAS3 is a newly cloned cytosolic β-class carbonic anhydrase (CA, EC 4.2.1.1) from the filamentous ascomycete Sordaria macrospora. This enzyme has a high catalytic activity for the physiological CO2 hydration reaction and herein, we report the inhibition profile of CAS3 with anions and small molecules. The most effective CAS3 anions/small molecule inhibitors were diethyl-dithiocarbamate, sulfamide,

    更新日期:2020-03-06
  • Volatile Metabolites in Liverworts of Ecuador
    Metabolites (IF 3.303) Pub Date : 2020-03-05
    Eduardo Valarezo; Oswaldo Tandazo; Kathia Galán; Jandry Rosales; Ángel Benítez

    Volatile metabolites from Frullania brasiliensis Raddi, Herbertus juniperoideus (Sw.) Grolle, Leptoscyphus hexagonus (Nees) Grolle, and Syzygiella anomala (Lindenb. & Gottsche) Steph collected in the south of Ecuador were investigated. Volatile secondary metabolites were extracted by hydrodistillation and analyzed by gas chromatography/flame ionization detector (GC/FID) and Gas chromatography/Mass

    更新日期:2020-03-06
  • Exercise Promotes the Osteoinduction of HA/β-TCP Biomaterials via the Wnt Signaling Pathway
    Metabolites (IF 3.303) Pub Date : 2020-03-05
    Lijia Cheng; Ahmad Taha Khalaf; Tianchang Lin; Ling Ran; Zheng Shi; Jun Wan; Xin Zhou; Liang Zou

    To investigate the osteoinductive mechanism triggered by hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) biomaterials in mice which keep exercising. Methods: The HA/β-TCP biomaterials were implanted in the muscle of bilateral thighs (non-osseous sites) of eighty Balb/C mice. All animals were then randomly divided into 4 groups (n = 20). In group 1 (negative control group), the mice were fed routinely

    更新日期:2020-03-06
  • A Cross-Sectional Study of Obesity Effects on the Metabolomic Profile of a Leptin-Resistant Swine Model
    Metabolites (IF 3.303) Pub Date : 2020-03-05
    M. Victoria Sanz-Fernandez; Laura Torres-Rovira; Jose L. Pesantez-Pacheco; Marta Vazquez-Gomez; Consolacion Garcia-Contreras; Susana Astiz; Antonio Gonzalez-Bulnes

    Identifying metabolite signatures associated with obesity and related diseases might represent a valuable preventive and therapeutic tool to predict subjects at risk, establish an accurate prognosis, and monitor treatment success. The current cross-sectional study is aimed to evaluate the metabolite profile of diet-induced obesity in a porcine model of leptin resistance. Six Iberian female pigs prone

    更新日期:2020-03-06
  • Analysis and Simulation of Glioblastoma Cell Lines-Derived Extracellular Vesicles Metabolome
    Metabolites (IF 3.303) Pub Date : 2020-03-02
    Miroslava Čuperlović-Culf; Nam H. Khieu; Anuradha Surendra; Melissa Hewitt; Claudie Charlebois; Jagdeep K. Sandhu

    Glioblastoma (GBM) is one of the most aggressive cancers of the central nervous system. Despite current advances in non-invasive imaging and the advent of novel therapeutic modalities, patient survival remains very low. There is a critical need for the development of effective biomarkers for GBM diagnosis and therapeutic monitoring. Extracellular vesicles (EVs) produced by GBM tumors have been shown

    更新日期:2020-03-02
  • Metabolite Shifts Induced by Marathon Race Competition Differ between Athletes Based on Level of Fitness and Performance: A Substudy of the Enzy-MagIC Study.
    Metabolites (IF 3.303) Pub Date : 2020-03-01
    Jana F Schader,Mark Haid,Alexander Cecil,Julia Schoenfeld,Martin Halle,Arne Pfeufer,Cornelia Prehn,Jerzy Adamski,David C Nieman,Johannes Scherr

    This study compared metabolite shifts induced by training for, participation in, and recovery from a marathon race competition among athletes divided into three groups based on fitness (relative maximum oxygen uptake (VO2max)) and performance levels (net running time). Plasma samples from 76 male runners participating in the Munich Marathon were analyzed for metabolite shifts using a targeted metabolomics

    更新日期:2020-03-02
  • Local Phenomena Shape Backyard Soil Metabolite Composition.
    Metabolites (IF 3.303) Pub Date : 2020-02-29
    Tra D Nguyen,Mahbobeh Lesani,Ines Forrest,Yunpeng Lan,Danya A Dean,Quentin M R Gibaut,Yanting Guo,Ekram Hossain,Marcela Olvera,Hannah Panlilio,Adwaita R Parab,Chaoyi Wu,Jean A Bernatchez,Robert H Cichewicz,Laura-Isobel McCall

    Soil covers most of Earth's continental surface and is fundamental to life-sustaining processes such as agriculture. Given its rich biodiversity, soil is also a major source for natural product drug discovery from soil microorganisms. However, the study of the soil small molecule profile has been challenging due to the complexity and heterogeneity of this matrix. In this study, we implemented high-resolution

    更新日期:2020-03-02
  • Identification and Validation of Metabolic Markers for Adulteration Detection of Edible Oils Using Metabolic Networks.
    Metabolites (IF 3.303) Pub Date : 2020-02-29
    Xinjing Dou,Liangxiao Zhang,Xiao Wang,Ruinan Yang,Xuefang Wang,Fei Ma,Li Yu,Jin Mao,Hui Li,Xiupin Wang,Peiwu Li

    Food adulteration is a challenge faced by consumers and researchers. Due to DNA fragmentation during oil processing, it is necessary to discover metabolic markers alternative to DNA for adulteration detection of edible oils. However, the contents of metabolic markers vary in response to various factors, such as plant species, varieties, geographical origin, climate, and cultivation measures. Thus,

    更新日期:2020-03-02
  • Chemical Fingerprints of Emotional Body Odor.
    Metabolites (IF 3.303) Pub Date : 2020-02-28
    Monique A M Smeets,Egge A E Rosing,Doris M Jacobs,Ewoud van Velzen,Jean H Koek,Cor Blonk,Ilse Gortemaker,Marloes B Eidhof,Benyamin Markovitch,Jasper de Groot,Gün R Semin

    Chemical communication is common among animals. In humans, the chemical basis of social communication has remained a black box, despite psychological and neural research showing distinctive physiological, behavioral, and neural consequences of body odors emitted during emotional states like fear and happiness. We used a multidisciplinary approach to examine whether molecular cues could be associated

    更新日期:2020-02-28
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