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Reproductive Enhancement through Phytochemical Characteristics and Biological Activities of Date Palm Pollen: A Comprehensive Review on Potential Mechanism Pathways Metabolites (IF 4.1) Pub Date : 2024-03-14 Saad Salhi, Abdellatif Rahim, Mouad Chentouf, Hasnaa Harrak, Jean Loup Bister, Naima Hamidallah, Bouchra El Amiri
Infertility represents a significant global health challenge affecting both men and women. Despite regular unprotected sexual intercourse, approximately 15% of couples of reproductive age struggle to conceive within 12 months, with 10% of infertility cases attributed to unknown causes worldwide. As a result, numerous studies have turned their attention to exploring the use of natural products for the
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Resting Metabolic Rate and Substrate Utilization during Energy and Protein Availability in Male and Female Athletes Metabolites (IF 4.1) Pub Date : 2024-03-17 Mahmoud M. A. Abulmeaty, Ali Almajwal, Mervat Elsayed, Heba Hassan, Thamer Alsager, Zaid Aldossari
Active athletes frequently develop low energy (LEA) and protein availabilities (LPA) with consequent changes in the vital metabolic processes, especially resting metabolic rate (RMR) and substrate utilization. This study investigated the association of energy and protein intakes with RMR and substrate utilization in male and female athletes and those with LEA and LPA. Sixty athletes (35% female, 26
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In Silico Analysis of Novel Bacterial Metabolites with Anticancer Activities Metabolites (IF 4.1) Pub Date : 2024-03-13 Pfariso Maumela, Mahloro Hope Serepa-Dlamini
Resistance to anticancer therapeutics is a major global concern. Thus, new anticancer agents should be aimed against novel protein targets to effectively mitigate the increased resistance. This study evaluated the potential of secondary metabolites from a bacterial endophyte, as new anticancer agents, against a novel protein target, fibroblast growth factor. In silico genomic characterization of the
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Serum Uric Acid/Serum Creatinine Ratio and Cardiovascular Mortality in Diabetic Individuals—The Uric Acid Right for Heart Health (URRAH) Project Metabolites (IF 4.1) Pub Date : 2024-03-14 Lanfranco D’Elia, Maria Masulli, Pietro Cirillo, Agostino Virdis, Edoardo Casiglia, Valerie Tikhonoff, Fabio Angeli, Carlo Maria Barbagallo, Michele Bombelli, Federica Cappelli, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Raffaella Dell’Oro, Giovambattista Desideri, Claudio Ferri, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Luciano Lippa, Francesca
Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some studies explored the role of the serum creatinine (sCr)-normalized SUA (SUA/sCr) ratio in different settings. Previously, the URRAH (URic acid Right for heArt Health) Study has identified a cut-off value of this index to predict
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The Effect of Dietary Protein Hydrolysate from Black Soldier Fly Larvae and Schizochytrium on Palatability, Nutrient Metabolites and Health Status in Beagle Dogs Metabolites (IF 4.1) Pub Date : 2024-03-14 Yu Wei, Lingfeng Xue, Deying Ma, Yuxiao Weng, Mingkang Liu, Luyang Li, Ziyi Dai, Ziyun Zhao, Haifeng Wang, Xiao Xu
Protein hydrolysate from black soldier fly larvae (BSFP) has garnered great attention with its lower allergenicity, high amount of essential amino acids, and small bioactive peptides. Schizochytrium is a promising alternative source of n-3 FUFA because it has enriched docosahexaenoic acid (DHA, C22: 6). The aim of this study was to assess palatability, the presence of diarrhea, plasma biochemistry
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Palmitate Compromises C6 Astrocytic Cell Viability and Mitochondrial Function Metabolites (IF 4.1) Pub Date : 2024-03-12 Luisa O. Schmitt, Antonella Blanco, Sheila V. Lima, Gianni Mancini, Natalia F. Mendes, Alexandra Latini, Joana M. Gaspar
Consumption of high-fat diets (HFD) is associated with brain alterations, including changes in feeding behavior, cognitive decline, and dementia. Astrocytes play a role in HFD-induced neuroinflammation and brain dysfunction; however, this process is not entirely understood. We hypothesized that exposure to saturated fatty acids can compromise astrocyte viability and mitochondrial function. The C6 (astrocytes)
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Balancing Risks and Benefits: Sodium-Glucose Cotransporter 2 Inhibitors and the Risk of Diabetic Ketoacidosis Metabolites (IF 4.1) Pub Date : 2024-03-13 Jan P. Kleinjan, Justin Blom, André P. van Beek, Hjalmar R. Bouma, Peter R. van Dijk
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are a new class of drugs that have been proven beneficial in the management of diabetes, chronic kidney disease, and heart failure and in the mitigation of cardiovascular risk. The benefits of SGLT2i therapy have led to the rapid adoption of these drugs in clinical guidelines. Since the introduction of these drugs, concerns have arisen, as diabetic
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Evaluation of Oil-Absorbing Film for Imprint Desorption Electrospray Ionization Mass Spectrometry Imaging (IDESI-MSI) on Biological Samples Metabolites (IF 4.1) Pub Date : 2024-03-11 Jiedong Li, Ruolun Wei, Yifan Meng, Richard N. Zare
Imprint Desorption Electrospray Ionization Mass Spectrometry Imaging (IDESI-MSI) has proven to be a robust and reliable tool for chemically imaging biological samples such as fungi, animal tissues, and plants, but the choice of the imprint substrate is crucial. It must effectively transfer maximum amounts of species from the sample while preserving the original spatial distribution of detected molecules
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Metabolomics and Lipidomics Analyses Aid Model Classification of Type 2 Diabetes in Non-Human Primates Metabolites (IF 4.1) Pub Date : 2024-03-09 Peining Tao, Stacey Conarello, Thomas P. Wyche, Nanyan Rena Zhang, Keefe Chng, John Kang, Theodore R. Sana
Type 2 diabetes (T2D) is a global public health issue characterized by excess weight, abdominal obesity, dyslipidemia, hyperglycemia, and a progressive increase in insulin resistance. Human population studies of T2D development and its effects on systemic metabolism are confounded by many factors that cannot be controlled, complicating the interpretation of results and the identification of early biomarkers
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Unravel the Supremacy of Klebsiella variicola over Native Microbial Strains for Aroma-Enhancing Compound Production in Reconstituted Tobacco Concentrate through Metagenomic Analysis Metabolites (IF 4.1) Pub Date : 2024-03-08 Shen Huang, Li Zhu, Ke Wang, Xinlong Zhang, Duobin Mao, Aamir Rasool
Sensory attributes strongly influence consumers’ preferences for products. The inoculation of the Klebsiella variicola H8 strain in a reconstituted tobacco leaf concentrate (RTLC) solution increased neutral aroma-enhancing compound (NAEC) production by 45%, decreased the nicotine level by 25%, decreased the water-soluble total sugar content by ~36%, and improved the sensory quality by 5.71%. The production
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Pesticides: Unintended Impact on the Hidden World of Gut Microbiota Metabolites (IF 4.1) Pub Date : 2024-03-07 Asghar Ali, Khalid I. AlHussaini
A vast range of pesticides have been routinely employed for plant protection throughout the last few decades. Pesticides can enter non-target organisms in various ways, posing health hazards. Exposure to different environmental pollutants, including pesticides, can affect the human gut flora. Metabolites generated from the gut microbiota play an essential role in the host’s health by regulating metabolic
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Machine Learning to Predict Enzyme–Substrate Interactions in Elucidation of Synthesis Pathways: A Review Metabolites (IF 4.1) Pub Date : 2024-03-07 Luis F. Salas-Nuñez, Alvaro Barrera-Ocampo, Paola A. Caicedo, Natalie Cortes, Edison H. Osorio, Maria F. Villegas-Torres, Andres F. González Barrios
Enzyme–substrate interactions play a fundamental role in elucidating synthesis pathways and synthetic biology, as they allow for the understanding of important aspects of a reaction. Establishing the interaction experimentally is a slow and costly process, which is why this problem has been addressed using computational methods such as molecular dynamics, molecular docking, and Monte Carlo simulations
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Daily Injection of the β2 Adrenergic Agonist Clenbuterol Improved Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Hyperlipidemia in Juvenile Lambs Following Heat-Stress-Induced Intrauterine Growth Restriction Metabolites (IF 4.1) Pub Date : 2024-03-07 Rachel L. Gibbs, James A. Wilson, Rebecca M. Swanson, Joslyn K. Beard, Zena M. Hicks, Haley N. Beer, Eileen S. Marks-Nelson, Ty B. Schmidt, Jessica L. Petersen, Dustin T. Yates
Stress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction (IUGR) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic outcomes. IUGR lambs that received daily injections of saline or the β2 agonist clenbuterol from birth to 60 days were compared with controls from
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Integrative Multiomics Approach to Skin: The Sinergy between Individualised Medicine and Futuristic Precision Skin Care? Metabolites (IF 4.1) Pub Date : 2024-03-07 Angelica Dessì, Roberta Pintus, Vassilios Fanos, Alice Bosco
The skin is a complex ecosystem colonized by millions of microorganisms, the skin microbiota, which are crucial in regulating not only the physiological functions of the skin but also the metabolic changes underlying the onset of skin diseases. The high microbial colonization together with a low diversity at the phylum level and a high diversity at the species level of the skin is very similar to that
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Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease Metabolites (IF 4.1) Pub Date : 2024-03-06 Saira Rafaqat, Sanja Gluscevic, Filiz Mercantepe, Sana Rafaqat, Aleksandra Klisic
Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics
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Integrating Genome Sequencing and Untargeted Metabolomics in Monozygotic Twins with a Rare Complex Neurological Disorder Metabolites (IF 4.1) Pub Date : 2024-03-04 Rulan Shaath, Aljazi Al-Maraghi, Haytham Ali, Jehan AlRayahi, Adam D. Kennedy, Karen L. DeBalsi, Sura Hussein, Najwa Elbashir, Sujitha S. Padmajeya, Sasirekha Palaniswamy, Sarah H. Elsea, Ammira A. Akil, Noha A. Yousri, Khalid A. Fakhro
Multi-omics approaches, which integrate genomics, transcriptomics, proteomics, and metabolomics, have emerged as powerful tools in the diagnosis of rare diseases. We used untargeted metabolomics and whole-genome sequencing (WGS) to gain a more comprehensive understanding of a rare disease with a complex presentation affecting female twins from a consanguineous family. The sisters presented with polymicrogyria
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5-ALA, DTA-6, and Nitrogen Mitigate NaCl Stress by Promoting Photosynthesis and Carbon Metabolism in Rice Seedlings Metabolites (IF 4.1) Pub Date : 2024-02-27 Yaxin Wang, Chaolu Tan, Yinghao Li, Fengyan Meng, Youwei Du, Shuyu Zhang, Wenxin Jiang, Naijie Feng, Liming Zhao, Dianfeng Zheng
A large number of dead seedlings can occur in saline soils, which seriously affects the large-scale cultivation of rice. This study investigated the effects of plant growth regulators (PGRs) and nitrogen application on seedling growth and salt tolerance (Oryza sativa L.), which is of great significance for agricultural production practices. A conventional rice variety, “Huang Huazhan”, was selected
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Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging Metabolites (IF 4.1) Pub Date : 2024-02-28 Eleni Mavrogonatou, Dimitris Kletsas
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration. On the other hand, an enhanced number of senescent cells has been identified in aged and degenerated intervertebral discs and their senescence-associated secretory phenotype (SASP) has been connected with qualitative/quantitative alterations
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Transcriptome in Liver of Periparturient Dairy Cows Differs between Supplementation of Rumen-Protected Niacin and Rumen-Protected Nicotinamide Metabolites (IF 4.1) Pub Date : 2024-03-01 Yuanjie Zhang, Rongrong Li, Xue’er Du, Zhijie Cui, Xingwei Jiang, Lamei Wang, Junhu Yao, Shimin Liu, Jianguo Wang, Chuanjiang Cai, Yangchun Cao
To investigate the difference between rumen-protected niacin (RPN) and rumen-protected nicotinamide (RPM) in the transcriptome of genes relating to the lipid metabolism of the liver of periparturient dairy cows, 10 healthy Chinese Holstein cows were randomly divided into two groups and fed diets supplemented with 18.4 g/d RPN or 18.7 g/d RPM, respectively. The experiment lasted from 14 days before
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In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer’s Disease Metabolites (IF 4.1) Pub Date : 2024-03-01 Jéssica Taday, Fernanda Telles Fróes, Marina Seady, Carlos Alberto Gonçalves, Marina Concli Leite
Astrocytes play fundamental roles in the maintenance of brain homeostasis. The dysfunction of these cells is widely associated with brain disorders, which are often characterized by variations in the astrocyte protein markers GFAP and S100B, in addition to alterations in some of its metabolic functions. To understand the role of astrocytes in neurodegeneration mechanisms, we induced some of these metabolic
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Diagnostic and Prognostic Performance of Metabolic Signatures in Pancreatic Ductal Adenocarcinoma: The Clinical Application of Quantitative NextGen Mass Spectrometry Metabolites (IF 4.1) Pub Date : 2024-02-29 Paulo D’Amora, Ismael D. C. G. Silva, Steven S. Evans, Adam J. Nagourney, Katharine A. Kirby, Brett Herrmann, Daniela Cavalheiro, Federico R. Francisco, Paula J. Bernard, Robert A. Nagourney
With 64,050 new diagnoses and 50,550 deaths in the US in 2023, pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of all human malignancies. Early detection and improved prognostication remain critical unmet needs. We applied next-generation metabolomics, using quantitative tandem mass spectrometry on plasma, to develop biochemical signatures that identify PDAC. We first compared plasma
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Advancing Personalized Medicine by Analytical Means: Selection of Three Metabolites That Allows Discrimination between Glaucoma, Diabetes, and Controls Metabolites (IF 4.1) Pub Date : 2024-02-29 David Bernal-Casas, Joan Serrano-Marín, Juan Sánchez-Navés, Josep M. Oller, Rafael Franco
Background: This paper aimed at devising an intelligence-based method to select compounds that can distinguish between open-angle glaucoma patients, type 2 diabetes patients, and healthy controls. Methods: Taking the concentration of 188 compounds measured in the aqueous humour (AH) of patients and controls, linear discriminant analysis (LDA) was used to identify the right combination of compounds
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Chemodiversity of Dissolved Soil Organic Matter from Amazon Rainforest as Influenced by Deforestation Metabolites (IF 4.1) Pub Date : 2024-02-28 Tancredo Souza, Damiana Justino Araujo, Carlos Alberto Lins Cassimiro, Diego Silva Batista
Many biogeochemical processes are modulated by dissolved organic matter (DOM), but the drivers influencing the chemodiversity of DOM compounds in Amazonian soils are poorly understood. It has also been theorized whether deforestation controls the decline of DOM. In this study, we collected soil samples from thirty sites across different regions of Brazil’s Legal Amazon, and we investigated the trade-offs
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Unraveling Metabolic Changes following Stroke: Insights from a Urinary Metabolomics Analysis Metabolites (IF 4.1) Pub Date : 2024-02-28 Jamie N. Petersson, Elani A. Bykowski, Chelsea Ekstrand, Sean P. Dukelow, Chester Ho, Chantel T. Debert, Tony Montina, Gerlinde A. S. Metz
The neuropathological sequelae of stroke and subsequent recovery are incompletely understood. Here, we investigated the metabolic dynamics following stroke to advance the understanding of the pathophysiological mechanisms orchestrating stroke recovery. Using a nuclear magnetic resonance (NMR)-driven metabolomic profiling approach for urine samples obtained from a clinical group, the objective of this
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Automated Spectrophotometric Assays for the Measurement of Ammonia and Bicarbonate in Saliva of Horses: Analytical Validation and Changes in Equine Gastric Ulcer Syndrome (EGUS) Metabolites (IF 4.1) Pub Date : 2024-02-28 Alberto Muñoz-Prieto, Eva Llamas-Amor, María Dolores Contreras-Aguilar, Ignacio Ayala, María Martín Cuervo, José Joaquín Cerón, Sanni Hansen
Ammonia (NH3) and bicarbonate (HCO3) have been related to gastric ulcers in humans. Ammonia is considered a possible cause of gastric ulcers, whereas bicarbonate has a protective function. The presence of ulcers in the stomach of horses is defined as Equine Gastric Ulcer Syndrome (EGUS), which is a frequent disease in this species, and it has been associated with changes in saliva composition, such
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Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes Metabolites (IF 4.1) Pub Date : 2024-02-27 Na An, Min Zhang, Quan-Fei Zhu, Yao-Yu Chen, Yan-Ling Deng, Xiao-Ying Liu, Qiang Zeng, Yu-Qi Feng
In vitro fertilization (IVF) is a highly effective treatment for infertility; however, it poses challenges for women with decreased ovarian reserve (DOR). Despite the importance of understanding the impact of DOR on IVF outcomes, limited research has explored this relationship, particularly using omics approaches. Hence, we conducted a study to investigate the association between DOR and IVF outcomes
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Effects of Different Feed Additives on Intestinal Metabolite Composition of Weaned Piglets Metabolites (IF 4.1) Pub Date : 2024-02-26 Mingxuan Zhao, Jian Zhang, Fuzhou Liu, Lv Luo, Mingbang Wei, Yourong Ye, Chamba Yangzom, Peng Shang
To study the effects of different feed additives on the weaning stress of Tibetan piglets, we selected 28 healthy, 30-day-old Tibetan weaned piglets and divided them into four groups, namely, the control group (basal feed without any antibiotic additions) (Nor), the group with the addition of the antibiotic lincomycin (Ant), the group with the addition of fifteen-flavor black pills of Tibetan medicine
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The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population Metabolites (IF 4.1) Pub Date : 2024-02-26 Zhongwen Chen, Huiwen Gu, Ruiqi Zhou, Shuqun Cheng
Herein, we explored the overall association between metal mixtures and lung functions in populations of varying ages and the relationship among the associated components. The 2007–2012 National Health and Nutrition Examination Survey data of 4382 American participants was analyzed, and generalized linear, elastic net, quantile g–computation, and Bayesian kernel machine regression models were used to
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Comparative Metabolomics of Ligulate and Tubular Flowers of Two Cultivars of Calendula officinalis L. Metabolites (IF 4.1) Pub Date : 2024-02-26 Vladimir Ossipov, Firdaus Khazieva, Dmitry Baleev, Juha-Pekka Salminen, Nikolay Sidelnikov
Calendula officinalis L. is a well-known plant widely used in traditional medicine due to the presence of various biologically active compounds. The main raw material for the production of medicinal preparations is the inflorescence, which consists of ligulate and tubular flowers. However, the characteristics of the metabolome of these flowers are not fully understood. This study identified and compared
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Employing 11-Ketotestosterone as a Target Analyte for Adrenosterone (11OXO) Administration in Doping Controls Metabolites (IF 4.1) Pub Date : 2024-02-26 Thomas Piper, Gregor Fußhöller, Mario Thevis
Adrenosterone (Androst-4-ene-3,11,17-trione, 11OXO) is forbidden in sports according to the Prohibited List of the World Anti-Doping Agency. The administration of 11OXO may be detected by monitoring the urinary concentrations of its main human metabolites 11β-hydroxy-androsterone and 11β-hydroxy-etiocholanolone. Preliminary urinary concentration and concentration ratio thresholds have been established
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Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study Metabolites (IF 4.1) Pub Date : 2024-02-25 Chuandi Jin, Guoping Zhao
Epidemiological studies have linked obesity to the onset of puberty, while its causality and the potential metabolite mediators remain unclear. We employed a two-sample Mendelian randomization (MR) design to evaluate the causal effects of obesity on puberty onset and its associated diseases including type 2 diabetes (T2D) and cardiovascular diseases (CVDs). The potential mediators in this pathway were
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Vertical Metabolome Transfer from Mother to Child: An Explainable Machine Learning Method for Detecting Metabolomic Heritability Metabolites (IF 4.1) Pub Date : 2024-02-24 Mario Lovrić, David Horner, Liang Chen, Nicklas Brustad, Ann-Marie Malby Schoos, Jessica Lasky-Su, Bo Chawes, Morten Arendt Rasmussen
Vertical transmission of metabolic constituents from mother to child contributes to the manifestation of disease phenotypes in early life. This study probes the vertical transmission of metabolites from mothers to offspring by utilizing machine learning techniques to differentiate between true mother–child dyads and randomly paired non-dyads. Employing random forests (RF), light gradient boosting machine
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Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation Metabolites (IF 4.1) Pub Date : 2024-02-22 Dandan Jia, Huijie Zhang, Tiemin Liu, Ru Wang
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the
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In-Situ Metabolic Profiling of Different Kinds of Rheum palmatum L. by Laser Desorption–Dielectric Barrier Discharge Ionization Mass Spectrometry Imaging Metabolites (IF 4.1) Pub Date : 2024-02-21 Xue Xiao, Xiaokang Guan, Zhouyi Xu, Qiao Lu
With its high resolving power and sensitivity, mass spectrometry is considered the most informative technique for metabolite qualitation and quantification in the plant sciences. However, the spatial location information, which is crucial for the exploration of plant physiological mechanisms, is lost. Mass spectrometry imaging (MSI) is able to visualize the spatial distribution of a large number of
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MIGRENE: The Toolbox for Microbial and Individualized GEMs, Reactobiome and Community Network Modelling Metabolites (IF 4.1) Pub Date : 2024-02-21 Gholamreza Bidkhori, Saeed Shoaie
Understanding microbial metabolism is crucial for evaluating shifts in human host–microbiome interactions during periods of health and disease. However, the primary hurdle in the realm of constraint-based modeling and genome-scale metabolic models (GEMs) pertaining to host–microbiome interactions lays in the efficient utilization of metagenomic data for constructing GEMs that encompass unexplored and
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Integrative Analysis of Cytokine and Lipidomics Datasets Following Mild Traumatic Brain Injury in Rats Metabolites (IF 4.1) Pub Date : 2024-02-21 Alexis N. Pulliam, Alyssa F. Pybus, David A. Gaul, Samuel G. Moore, Levi B. Wood, Facundo M. Fernández, Michelle C. LaPlaca
Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary injury phase, TBI is characterized by complex secondary cascades that involve altered homeostasis and metabolism, faulty signaling, neuroinflammation,
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Circadian Disruption across Lifespan Impairs Glucose Homeostasis and Insulin Sensitivity in Adult Mice Metabolites (IF 4.1) Pub Date : 2024-02-16 Tracy K. Her, Jin Li, Hao Lin, Dong Liu, Kate M. Root, Jean F. Regal, Emilyn U. Alejandro, Ruifeng Cao
Circadian rhythm disruption is associated with impaired glucose homeostasis and type 2 diabetes. For example, night shift work is associated with an increased risk of gestational diabetes. However, the effects of chronic circadian disruption since early life on adult metabolic health trajectory remain unknown. Here, using the “Short Day” (SD) mouse model, in which an 8 h/8 h light/dark (LD) cycle was
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Association of Dietary Protein Sources and Their Adequacy, Body Composition and Risk of Sarcopenic Obesity in South Korean Populations: A Cross-Sectional Study Metabolites (IF 4.1) Pub Date : 2024-02-19 Jieun Kim, Kyoungsik Jeong, Sueun Lim, Siwoo Lee, Younghwa Baek
Dietary protein sources and protein adequacy are crucial modulators of muscle quality and body composition. We investigated the association between dietary protein sources (and their adequacy) and body composition and the risk of sarcopenic obesity (SO) in South Korean populations. The participants (n = 1967) were classified into SO, obese, sarcopenia, and normal groups. A cross-sectional survey was
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Phytocompounds and Regulation of Flavonoids in In Vitro-Grown Safflower Plant Tissue by Abiotic Elicitor CdCl2 Metabolites (IF 4.1) Pub Date : 2024-02-16 Bushra Ejaz, Abdul Mujib, Rukaya Syeed, Jyoti Mamgain, Moien Qadir Malik, Kanchan Birat, Yaser Hassan Dewir, Katalin Magyar-Tábori
In this study, a Gas chromatography–mass spectrometry (GC–MS) investigation of embryogenic callus and somatic embryo regenerated shoots of Carthamus tinctorius revealed the presence of a variety of sugars, sugar acids, sugar alcohols, fatty acids, organic acids, and amino acids of broad therapeutic value. The in vitro developed inflorescence contained a wide range of active compounds. In embryogenic
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Urinary Metabolomic Differentiation of Infants Fed on Human Breastmilk and Formulated Milk Metabolites (IF 4.1) Pub Date : 2024-02-16 Ji-Woo Yu, Min-Ho Song, Ji-Ho Lee, Jun-Hwan Song, Won-Ho Hahn, Young-Soo Keum, Nam Mi Kang
Human breastmilk is an invaluable nutritional and pharmacological resource with a highly diverse metabolite profile, which can directly affect the metabolism of infants. Application of metabolomics can discriminate the complex relationship between such nutrients and infant health. As the most common biological fluid in metabolomic study, infant urinary metabolomics may provide the physiological impacts
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The Efficacy of Lactobacillus delbrueckii ssp. bulgaricus Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial Metabolites (IF 4.1) Pub Date : 2024-02-16 Pei-Yi Chu, Ying-Chun Yu, Yi-Cheng Pan, Yun-Hao Dai, Juan-Cheng Yang, Kuo-Chin Huang, Yang-Chang Wu
This study aimed to evaluate the efficacy of Lactobacillus delbrueckii ssp. bulgaricus (L. bulgaricus) in improving body weight, obesity-related outcomes, and lipid profiles of overweight people. Thirty-six overweight participants were randomly assigned to either a probiotic or a placebo group. A placebo powder or L. bulgaricus powder (containing 1 × 108 colony-forming unit (CFU) of the probiotic)
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metabCombiner 2.0: Disparate Multi-Dataset Feature Alignment for LC-MS Metabolomics Metabolites (IF 4.1) Pub Date : 2024-02-15 Hani Habra, Jennifer L. Meijer, Tong Shen, Oliver Fiehn, David A. Gaul, Facundo M. Fernández, Kaitlin R. Rempfert, Thomas O. Metz, Karen E. Peterson, Charles R. Evans, Alla Karnovsky
Liquid chromatography–high-resolution mass spectrometry (LC-HRMS), as applied to untargeted metabolomics, enables the simultaneous detection of thousands of small molecules, generating complex datasets. Alignment is a crucial step in data processing pipelines, whereby LC-MS features derived from common ions are assembled into a unified matrix amenable to further analysis. Variability in the analytical
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Exposure to OPFRs Is Associated with Obesity and Dysregulated Serum Lipid Profiles: Data from 2017–2018 NHANES Metabolites (IF 4.1) Pub Date : 2024-02-13 He Li, Fenglin Li, Chaoyi Zhou, Jifan Bu, Hao Yang, Liangchen Zhong, Weilong Xing, Liangzhong Li
Widespread exposure to organophosphorus flame retardants (OPFRs) has been observed in the general population. Emerging studies have revealed OPFRs possess endocrine-disturbing properties. The present study aims to assess the association between urinary metabolites of OPFRs, BMI, and serum lipid profiles. Data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 were obtained
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Longitudinal Profiling of Fasting Plasma Metabolome in Response to Weight-Loss Interventions in Patients with Morbid Obesity Metabolites (IF 4.1) Pub Date : 2024-02-10 Mingjing Chen, Guanhong Miao, Zhiguang Huo, Hao Peng, Xiaoxiao Wen, Stephen Anton, Dachuan Zhang, Gang Hu, Ricky Brock, Phillip J. Brantley, Jinying Zhao
It is well recognized that patients with severe obesity exhibit remarkable heterogeneity in response to different types of weight-loss interventions. Those who undergo Roux-en-Y gastric bypass (RYGB) usually exhibit more favorable glycemic outcomes than those who receive adjustable gastric banding (BAND) or intensive medical intervention (IMI). The molecular mechanisms behind these observations, however
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ApoB100 and Atherosclerosis: What’s New in the 21st Century? Metabolites (IF 4.1) Pub Date : 2024-02-12 Dimitris Kounatidis, Natalia G. Vallianou, Aikaterini Poulaki, Angelos Evangelopoulos, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Maria Dalamaga
ApoB is the main protein of triglyceride-rich lipoproteins and is further divided into ApoB48 in the intestine and ApoB100 in the liver. Very low-density lipoprotein (VLDL) is produced by the liver, contains ApoB100, and is metabolized into its remnants, intermediate-density lipoprotein (IDL) and low-density lipoprotein (LDL). ApoB100 has been suggested to play a crucial role in the formation of the
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A Decrease in Branched-Chain Amino Acids after a Competitive Male Professional Volleyball Game—A Metabolomic-Based Approach Metabolites (IF 4.1) Pub Date : 2024-02-09 Taillan Martins Oliveira, Tathiany Jéssica Ferreira, Paula Albuquerque Penna Franca, Rudson Ribeiro da Cruz, Mauricio Gattás Bara-Filho, Fábio Luiz Candido Cahuê, Ana Paula Valente, Anna Paola Trindade Rocha Pierucci
A competitive volleyball game is a highly metabolic and physically demanding event for professional players. This study aimed to investigate whether a single game at the end of a preseason promotes changes in the biochemical markers of physical exercise responses and the metabolomic profile of professional volleyball players. This cross-sectional study included 13 male Brazilian professional volleyball
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Exploring the Significance, Extraction, and Characterization of Plant-Derived Secondary Metabolites in Complex Mixtures Metabolites (IF 4.1) Pub Date : 2024-02-11 Ruchi Barthwal, Rohit Mahar
Secondary metabolites are essential components for the survival of plants. Secondary metabolites in complex mixtures from plants have been adopted and documented by different traditional medicinal systems worldwide for the treatment of various human diseases. The extraction strategies are the key components for therapeutic development from natural sources. Polarity-dependent solvent-selective extraction
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Metabolomics Reveals Antioxidant Metabolites in Colored Rice Grains Metabolites (IF 4.1) Pub Date : 2024-02-11 Jinyan Zhu, Ruizhi Wang, Yu Zhang, Yanyao Lu, Shuo Cai, Qiangqiang Xiong
Colored rice is richer in nutrients and contains more nutrients and bioactive substances than ordinary white rice. Moderate consumption of black (purple) rice has a variety of physiological effects, such as antioxidant effects, blood lipid regulation, and blood sugar control. Therefore, we utilized nontargeted metabolomics, quantitative assays for flavonoid and phenolic compounds, and physiological
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Intestinal Dysbiosis in Subjects with Obesity from Western Mexico and Its Association with a Proinflammatory Profile and Disturbances of Folate (B9) and Carbohydrate Metabolism Metabolites (IF 4.1) Pub Date : 2024-02-11 Verónica Riggen-Bueno, Susana Del Toro-Arreola, Tonatiuh Abimael Baltazar-Díaz, Alejandra N. Vega-Magaña, Marcela Peña-Rodríguez, Paula Alejandra Castaño-Jiménez, Laura Verónica Sánchez-Orozco, José María Vera-Cruz, Miriam Ruth Bueno-Topete
Obesity is a public health problem with a growing prevalence worldwide. In Mexico, it is estimated that one out of three adults suffer from obesity. In these patients, the intestinal microbiota (IM) undergoes pathological changes that are associated with a dysbiotic state; however, the microbiota profile of adult subjects with obesity from western Mexico has not been described. To assess this, fecal
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Effects of Astragaloside IV on Hearing, Inflammatory Factors, and Intestinal Flora in Mice Exposed to Noise Metabolites (IF 4.1) Pub Date : 2024-02-11 Junyi Li, Jian Yang, Yun Xia, Junyi Wang, Yuan Xia
Long-term exposure to noise can cause irreversible hearing loss. Considering that there is no effective drug treatment, it is important to seek preventive treatment for noise-induced hearing loss (NIHL). Although astragaloside IV (AS-IV) protects against NIHL by reducing serum inflammatory factors, there is scarce information on the regulation of inflammatory factors by AS-IV to prevent NIHL. We investigated
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Implementation of FAIR Practices in Computational Metabolomics Workflows—A Case Study Metabolites (IF 4.1) Pub Date : 2024-02-10 Mahnoor Zulfiqar, Michael R. Crusoe, Birgitta König-Ries, Christoph Steinbeck, Kristian Peters, Luiz Gadelha
Scientific workflows facilitate the automation of data analysis tasks by integrating various software and tools executed in a particular order. To enable transparency and reusability in workflows, it is essential to implement the FAIR principles. Here, we describe our experiences implementing the FAIR principles for metabolomics workflows using the Metabolome Annotation Workflow (MAW) as a case study
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Anti-Hyperuricemic Effects of Extracts from Chaenomeles speciosa (Sweet) Nakai Fruits on Hyperuricemic Rats Metabolites (IF 4.1) Pub Date : 2024-02-10 Ruoling Xu, Peng Deng, Yiren Ma, Kui Li, Fucai Ren, Ning Li
Chaenomeles speciosa (Sweet) Nakai (C. speciosa) fruit has medicinal and food applications and exhibits beneficial pharmacological properties. This study aimed to explore the hypouricemic effect of C. speciosa fruit extracts on hyperuricemic rats and uncover potential protective mechanisms. The rats were given hypoxanthine (HX, 100 mg/kg) and potassium oxonate (PO, 300 mg/kg) for 14 days to induce
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Kinetic Modeling of Brain [18-F]FDG Positron Emission Tomography Time Activity Curves with Input Function Recovery (IR) Method Metabolites (IF 4.1) Pub Date : 2024-02-08 Marco Bucci, Eleni Rebelos, Vesa Oikonen, Juha Rinne, Lauri Nummenmaa, Patricia Iozzo, Pirjo Nuutila
Accurate positron emission tomography (PET) data quantification relies on high-quality input plasma curves, but venous blood sampling may yield poor-quality data, jeopardizing modeling outcomes. In this study, we aimed to recover sub-optimal input functions by using information from the tail (5th–100th min) of curves obtained through the frequent sampling protocol and an input recovery (IR) model trained
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Relationship of Thyroid Function with Renal Hemodynamics and Cholesterol Metabolism in Proteinuric Kidney Disease: A Pilot Study Metabolites (IF 4.1) Pub Date : 2024-02-07 Yoshitaka Iwazu, Kazuhiko Kotani, Taro Sugase, Daisuke Nagata, Toshiyuki Yamada
Nephrotic syndrome and hypothyroidism are respectively reported to influence renal hemodynamics and hypercholesterolemia. However, the relationship of proteinuria-associated thyroid function with renal hemodynamics and cholesterol metabolism has yet to be determined in a simultaneous analysis of thyroid, renal, and cholesterol variables. We investigated the hypothesis that the changes in thyroid hormones
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Data-Driven Characterization of Metabolome Reprogramming during Early Development of Sorghum Seedlings Metabolites (IF 4.1) Pub Date : 2024-02-07 Ian A. Dubery, Lerato P. Nephali, Fidele Tugizimana, Paul A. Steenkamp
Specialized metabolites are produced via discrete metabolic pathways. These small molecules play significant roles in plant growth and development, as well as defense against environmental stresses. These include damping off or seedling blight at a post-emergence stage. Targeted metabolomics was followed to gain insights into metabolome changes characteristic of different developmental stages of sorghum
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Resurrection Plants—A Valuable Source of Natural Bioactive Compounds: From Word-of-Mouth to Scientifically Proven Sustainable Use Metabolites (IF 4.1) Pub Date : 2024-02-07 Dimitar Djilianov, Daniela Moyankova, Petko Mladenov, Tanya Topouzova-Hristova, Aneliya Kostadinova, Galya Staneva, Diana Zasheva, Strahil Berkov, Lyudmila Simova-Stoilova
Resurrection plant species are a group of higher plants whose vegetative tissues are able to withstand long periods of almost full desiccation and recover quickly upon rewatering. Apart from being a model system for studying desiccation tolerance, resurrection plant species appear to be a valuable source of metabolites, with various areas of application. A significant number of papers have been published
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Metabolomics Reveals the Effects of Nitrogen/Phosphorus/Potassium (NPK) Fertilizer Levels on Cucumber Fruit Raised in Different Nutrient Soils Metabolites (IF 4.1) Pub Date : 2024-02-01 Na-Rae Lee, Yangmin X. Kim, Yerim Lee, Chanwook Lee, Yosung Song, Hyejin Park, Choong Hwan Lee, Yejin Lee
Fertilizers are widely used to improve the quality of fruits and vegetables. However, the overuse of fertilizers has become an issue because it causes environmental problems and negatively affects productivity and fruit quality. In this study, we examined the effects of nitrogen, phosphorus, and potassium (NPK) fertilizer levels on the metabolism of cucumber fruit in low- and high-nutrient soils using
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Metabolic Profiling of Aromatic Compounds Metabolites (IF 4.1) Pub Date : 2024-02-05 Alisa K. Pautova
Metabolic profiling is a powerful modern tool in searching for novel biomarkers and indicators of normal or pathological processes in the body [...]
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Deciphering the Role of the Gut Microbiota in Exposure to Emerging Contaminants and Diabetes: A Review Metabolites (IF 4.1) Pub Date : 2024-02-06 Xueqing Li, Huixia Niu, Zhengliang Huang, Man Zhang, Mingluan Xing, Zhijian Chen, Lizhi Wu, Peiwei Xu
Emerging pollutants, a category of compounds currently not regulated or inadequately regulated by law, have recently become a focal point of research due to their potential toxic effects on human health. The gut microbiota plays a pivotal role in human health; it is particularly susceptible to disruption and alteration upon exposure to a range of toxic environmental chemicals, including emerging contaminants
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Metabolomic Profiling of Blood Plasma in Females with Hyperplasia and Endometrial Cancer Metabolites (IF 4.1) Pub Date : 2024-02-06 Hicham Benabdelkamel, Malak A. Jaber, Khalid Akkour, Reem H. AlMalki, Assim A. Alfadda, Afshan Masood, Salini Scaria Joy, Hani Alhalal, Moudi A. Alwehaibi, Maria Arafah, Eman Alshehri, Anas M. Abdel Rahman
Uterine cancer is the most prevalent gynecologic malignancy in women worldwide. Endometrial cancer (EC) has an 81% five-year survival rate, depending on disease stage and time of diagnosis. While endometrial cancer is largely treatable when detected early, no established screening techniques are available in clinical practice. As a result, one of the most significant issues in the medical field is