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Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway. Free Radic. Res. (IF 3.3) Pub Date : 2024-03-13 Yixin Zhang, Youcheng Zeng, Ming Huang, Guodong Cao, Liang Lin, Xiaoyue Wang, Qinghong Cheng
Sepsis is a systemic inflammatory response syndrome caused by infection, which causes renal dysfunction known as sepsis-associated acute kidney injury (S-AKI). Ferroptosis is a form of lipid peroxi...
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Superoxide-producing associates from gastrointestinal bacteria: stimulation of its growth by exogenous superoxide-producing complex from raspberries Free Radic. Res. (IF 3.3) Pub Date : 2024-03-01 Ruzan M. Simonyan, Sona M. Feschyan, Roza A. Madoyan, Gegham M. Simonyan, Hasmik H. Sargsyan, Madlena A. Babayan, Hasmik H. Yekmalyan, Magdalina M. Melkonyan, Maxim A. Simonyan, Ashkhen L. Manukyan
Aerobic organisms including the gut microbiota have an essential antioxidant status, as a result of which these bacteria protect organisms from various pathologies and diseases. The goal of the giv...
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Ameliorative effect of salidroside on the cyclophosphamide-induced premature ovarian failure in a rat model Free Radic. Res. (IF 3.3) Pub Date : 2024-02-26 Lixuan Chen, Qinglin Mo, Yingnan Wu, Wancheng Chen, Kaixian Deng, Yang Xiao
Background: Oxidative stress injury is an important pathological factor of premature ovarian failure(POF). Salidroside, extracted from the Chinese herb -Rhodiola rosea, has advantages in antioxidan...
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Brca2(p.T1942fs/+) dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells Free Radic. Res. (IF 3.3) Pub Date : 2024-02-23 Hideaki Tanaka, Yashiro Motooka, Yuki Maeda, Reina Sonehara, Tomoko Nakamura, Hiroaki Kajiyama, Tomoji Mashimo, Shinya Toyokuni
Pathogenic variants of BRCA1/2 constitute hereditary breast and ovarian cancer (HBOC) syndrome, and BRCA1/2 mutant is a risk for various cancers. Whereas the clinical guideline for HBOC patients ha...
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Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer Free Radic. Res. (IF 3.3) Pub Date : 2024-02-22 Kaiyuan Wu, Le Liu, Zhenhua Wu, Qi Huang, Lei Zhou, Rujiao Xie, Miao Wang
Ferroptosis is recognized as a new type of regulated cell death initiated by iron-dependent accumulation of lipid peroxidation. Recent studies have shown that the administration of ascorbic acid (A...
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The Role of Oxidative Stress and Inflammation Biomarkers in Pre- and Postoperative Monitoring of Prostate Cancer Patients Free Radic. Res. (IF 3.3) Pub Date : 2024-02-19 Hakan Beyaztas, Cevper Ersoz, Beyza Nur Ozkan, Ibrahim Olgun, Hayati Sencer Polat, Ali Imran Dastan, Emre Cetinkaya, Eray Metin Guler
Prostate Cancer (PC) is a global health concern affecting men worldwide. Oxidative stress is believed to contribute to the initiation of early-stage PC lesions. Additionally, inflammation has long ...
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Enhancing effect of the coexisting alpha-tocopherol on quercetin absorption and metabolism. Free Radic. Res. (IF 3.3) Pub Date : 2024-02-08 Rikito Mitsuzane, Reiko Okubo, Miyu Nishikawa, Shinichi Ikushiro, Shintaro Munemasa, Yoshiyuki Murata, Yoshimasa Nakamura, Toshiyuki Nakamura
The aim of this study is to investigate the modulating effect of coexisting food components on the absorption and metabolism of quercetin and blood plasma antioxidant potentials. The combination of...
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Renoprotective effect of esculetin against ischemic acute kidney injury-diabetic comorbidity Free Radic. Res. (IF 3.3) Pub Date : 2024-02-07 Neha Dagar, Tahib Habshi, Vishwadeep Shelke, Hemant R. Jadhav, Anil Bhanudas Gaikwad
Mitophagy maintains cellular homeostasis by eliminating damaged mitochondria. Accumulated damaged mitochondria can lead to oxidative stress and cell death. Induction of the PINK1/Parkin-mediated mi...
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Bis(1-methylimidazol-2-yl) diselenide and its evaluation as a chemical radio-protector: role of kinetic rate constants for ROS scavenging and glutathione peroxidase like activity Free Radic. Res. (IF 3.3) Pub Date : 2024-02-07 K. Makhijani, L. B. Kumbhare, M. Nayak, A. Kunwar, B. G. Singh
Bis(1-methylimidazol-2-yl) diselenide (MeImSe), a derivative of selenoneine, has been examined for bimolecular rate constants for scavenging of various radiolytically and non-radiolytically generat...
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Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice Free Radic. Res. (IF 3.3) Pub Date : 2024-02-07 Xianchao Li, Yang Wu, Yunzhao Yang, Yaohua Wu, Xi Yu, Wenjuan Hu
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcriptional regulator that plays a protective role against various cardiovascular diseases. Omaveloxolone is a newly discovere...
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Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH Free Radic. Res. (IF 3.3) Pub Date : 2024-02-07 Lucia Kovacikova, Marta S. Prnova, Pavol Bodo, Milan Stefek
In the model system of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) liposomes exposed to peroxyl radicals generated by the azoinitiator AAPH, cemtirestat (CMTI-SH) inhibited lipid peroxidation m...
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A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages Free Radic. Res. (IF 3.3) Pub Date : 2024-02-07 Gaochao Dong, Xuewen Yin, Yingkuan Liang, Jingwen Chen, Jie Wang, Feng Jiang, Chaochen Wang, Wenwen Guo, Yaping Wang
An inverted AluYb8 insertion in the MUTYH intron 15 (AluYb8MUTYH variant) has been reported to be associated with reduced MUTYH1 expression and mitochondrial dysfunction with age. However, the unde...
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Recent advances in the antioxidant activity of metal-curcumin complexes: a combined computational and experimental review Free Radic. Res. (IF 3.3) Pub Date : 2024-02-07 Ankit Mittal, Mudita Nagpal, Vinod Kumar Vashistha, Richa Arora, Upasana Issar
Curcumin, an extensively studied phytochemical compound, has gained attention for its potential therapeutic applications across a spectrum of diseases. Its notable attributes include its relatively...
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Pharmacological inhibition of SIRT-2 by AK-7 modulates redox status and apoptosis via regulating Nrf2 in an experimental model of chronic obstructive pulmonary disease: an invivo and insilico study Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Vandana Yadav, Vinita Pandey, Atul Srivastava, Sangita Singh, Subhashini
Chronic obstructive pulmonary disease (COPD) is defined by inflammation and emphysema. Sirtuins (SIRT) are NAD+-dependent histone deacetylases that regulate oxidative stress and inflammation. The p...
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Effect of the nature of the chelated metal on the photodynamic activity of metalloporphyrins Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Ghadeer Abbas, Fatemah Alibrahim, Rawan Kankouni, Sara Al-Belushi, Dalal A. Al-Mutairi, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov
Coordination of metal ions by the tetrapyrrolic macrocyclic ring of porphyrin-based photosensitizers (PSs) affects their photophysical properties and consequently, their photodynamic activity. Diam...
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Elevated oxidative stress in patients with congenital heart disease and the effect of cyanosis: a meta-analysis Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Inne Vanreusel, Jan Taeymans, Emeline Van Craenenbroeck, Vincent F. M. Segers, An Van Berendoncks, Jacob J. Briedé, Wendy Hens
Oxidative stress is an important pathophysiological mechanism in the development of numerous cardiovascular disorders. To improve therapy and preventive strategies, clinicians need a better underst...
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N-acetylcysteine modulates redox imbalance and inflammation in macrophages and mice exposed to formaldehyde Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Elena Cecilia Marcano-Gómez, Ana Beatriz Farias de Souza, Pedro Alves Machado-Junior, Andrea Jazel Rodríguez-Herrera, Thalles de Freitas Castro, Sirlaine Pio Gomes da Silva, Ramony Gonzaga Vieira, André Talvani, Katiane de Oliveira Pinto Coelho Nogueira, Laser Antônio Machado de Oliveira, Frank Silva Bezerra
This study aimed to evaluate the protective role of N-acetylcysteine (NAC) in cells and mice exposed to formaldehyde. For the in vitro study, J774A.1 macrophages cells were incubated for 8, 16 and ...
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The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Andris Elksnis, Nils Welsh, Per Wikström, Joey Lau, Per-Ola Carlsson
NADPH oxidase 4 (NOX4) inhibition has been reported to mitigate diabetes-induced beta-cell dysfunction and improve survival in vitro, as well as counteract high-fat diet-induced glucose intolerance...
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Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Yunguang Wang, Xinxin He, Mengjiao Xue, Wenbo Sun, Qiang He, Juan Jin
Mitophagy is a critical intracellular event during the progression of diabetic nephropathy (DN). Our previous study demonstrated that germacrone has anti-ferroptotic properties and is a potential t...
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Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Mana Kitao, Ai Yamaguchi, Takuma Tomioka, Kenji Kai, Yuki Kamei, Kenji Sugimoto, Mitsugu Akagawa
Age-related macular degeneration (AMD) is one of an increasing number of diseases that causes irreversible impairment and loss of vision in the elderly. AMD occurs by oxidative stress-mediated apop...
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The relationship between serum superoxide dismutase and thyroid function in obese patients after Laparoscopic sleeve gastrectomy Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Hui You, Xin Wen, Xingchun Wang, Cuiling Zhu, Manna Zhang, Le Bu, Haibing Chen, Chunjun Sheng, Shen Qu
To investigate the cross-sectional and longitudinal correlation between serum superoxide dismutase (SOD) levels and thyroid function with obesity before and after laparoscopic sleeve gastrectomy (L...
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Rhabdomyolysis aggravates renal iron accumulation and acute kidney injury in a humanized mouse model of sickle cell disease Free Radic. Res. (IF 3.3) Pub Date : 2023-12-26 Jada D. Williams, Ravi Kumar, Jeremiah M. Afolabi, Frank Park, Adebowale Adebiyi
Individuals with sickle cell disease (SCD) are at greater risk of rhabdomyolysis, a potentially life-threatening condition resulting from the breakdown of skeletal muscle fibers. Acute kidney injur...
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Epoxides: an underestimated lipid oxidation product Free Radic. Res. (IF 3.3) Pub Date : 2023-12-20 Karen M. Schaich
Immense gains in understanding of mechanisms and effects of lipid oxidation have been achieved in the nearly 90 years over which lipid oxidation has been an active research focus. Even so, the subs...
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Arachidonic Acid: Reconciling the Dichotomy of its Oxidative Cascade through Specific Deuteration Free Radic. Res. (IF 3.3) Pub Date : 2023-10-28 J. Thomas Brenna, Marina G. Sergeeva, Nikolay B. Pestov, Tatyana V. Korneenko, Mikhail S. Shchepinov
A new approach to attenuating pathological inflammatory reactions by buffering the eicosanoid pathways with oxidation-resistant hexadeuterated arachidonic acid (D-ARA) is discussed. Enzymatic proce...
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Continuously increased generation of ROS in human plasma after cardiac arrest as determined by Amplex Red oxidation Free Radic. Res. (IF 3.3) Pub Date : 2023-08-29 Muhammad Shoaib, Nancy Kim, Rishabh C. Choudhary, Blanca Espin, Mitsuaki Nishikimi, Ann Iverson, Tsukasa Yagi, Seyedeh Shadafarin Marashi Shoshtari, Koichiro Shinozaki, Lance B. Becker, Junhwan Kim
Abstract Oxidative stress is believed to be a major cause of injury after cardiac arrest (CA). While the effects of ROS generated within tissues have been extensively investigated, the potential of plasma-generated ROS in contributing to CA pathology has not been examined. We utilized Amplex Red (AR) to measure the real time-generation of ROS in isolated plasma from human CA patients. We first used
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Molecular targets for anti-oxidative protection of açaí berry against diabetes myocardial ischemia/reperfusion injury Free Radic. Res. (IF 3.3) Pub Date : 2023-08-26 Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Tiziana Genovese, Rosalia Crupi, Livia Interdonato, Maurizio Evangelista, Rosanna Di Paola, Salvatore Cuzzocrea, Ramona D’Amico
Myocardial ischemia/reperfusion injury (MIRI) is the principal cause of death and occurs after prolonged blockage of the coronary arteries. Diabetes represents one of the main factors aggravating m...
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Fullerene C60 reduces acute lung injury by suppressing oxidative stress-mediated DMBA-induced apoptosis and autophagy by regulation of cytochrome-C/caspase-3/beclin-1/IL-1α/HO-1/p53 signaling pathways in rats Free Radic. Res. (IF 3.3) Pub Date : 2023-08-26 Seda Beyaz, Abdullah Aslan, Ozlem Gok, Ibrahim Hanifi Ozercan, Can Ali Agca
Abstract The objective of this study was to evaluate the effect of fullerene C60 nanoparticles against 7,12-dimethylbenz[a]anthracene (DMBA)-induced lung tissue damage in rats. 60 Wistar albino (8 weeks old) female rats were assigned into four groups: Control Group (C), Fullerene C60, DMBA, and Fullerene C60+DMBA. The rats in the DMBA and Fullerene C60+DMBA groups were administered DMBA (45 mg/kg bw
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Defense systems to avoid ferroptosis caused by lipid peroxidation-mediated membrane damage Free Radic. Res. (IF 3.3) Pub Date : 2023-08-09 Junichi Fujii, Ken-ichi Yamada
The presence of hydrogen peroxide along with ferrous iron produces hydroxyl radicals that preferably oxidize polyunsaturated fatty acids (PUFA) to alkyl radicals (L•). The reaction of L• with an ox...
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DhHP-6 alleviates inflammation and reduces vascular permeability by eliminating reactive oxygen species Free Radic. Res. (IF 3.3) Pub Date : 2023-08-03 Fanwei Meng, Junfeng Ke, Feng Guo, Jiaqing Yan, Liping Wang
Abstract Inflammation is a defensive immune response to external stimuli. However, uncontrolled inflammation may cause potential damage to the host. Therefore, timely control of uncontrolled inflammation is particularly important. Previous studies have found that small molecules with antioxidant activity, such as peroxidase mimic enzymes, can inhibit the development of inflammation. DhHP-6 is a new
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Molecular dissection of anti-colon cancer activity of NARI-29: Special focus on H2O2 modulated NF-κB and death receptor signaling Free Radic. Res. (IF 3.3) Pub Date : 2023-07-31 Syamprasad NP, Bishal Rajdev, Siddhi Jain, Jagadeesh Kumar Gangasani, Jayathirtha Rao Vaidya, VGM Naidu
Abstract Accumulating evidence attributes the role of aldose reductase (AR) in modulating ROS and inflammation which are the main factor responsible for cancer progression and drug resistance. Epalrestat is the only AR inhibitor being used in Asian countries. It did not make it to the markets of the USA and Europe due to marginal efficacy as an antioxidant and anti-inflammatory agent owing to difficulty
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Association of Circulatory PCSK-9 with Biomarkers of Redox Imbalance and Inflammatory Cascades in the Prognosis of Diabetes and Associated Complications: A Pilot Study in the Indian Population Free Radic. Res. (IF 3.3) Pub Date : 2023-07-17 Mohd Waiz, Sahir Sultan Alvi, M. Salman Khan
Abstracts Besides the profound role of proprotein convertase subtilisin/kexin type-9 (PCSK-9) in LDL-C regulation, its association with other metabolic complications cannot be disregarded. The co-existence of redox imbalance and inflammatory cascades has greatly reflected the etiology of hyperglycemia. Therefore, we studied the association of PCSK-9 with inflammation and oxidative stress biomarkers
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Dissecting the potential role of ferroptosis in liver diseases: an updated review Free Radic. Res. (IF 3.3) Pub Date : 2023-07-04 Gaoyue Guo, Wanting Yang, Chao Sun, Xiaoyu Wang
Abstract Ferroptosis is a novel form of cell death, manifested by iron-dependent, non-apoptotic manner resulting from the intracellular accumulation of large clusters of reactive oxygen species (ROS) and lipid peroxides due to abnormal iron metabolism. Since the liver is the main organ of human body for storing iron, it is essential to perform in-depth investigation on the role and mechanistic basis
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Formation of free radicals in Chi-aroma Baijiu during aging process with fat pork Free Radic. Res. (IF 3.3) Pub Date : 2023-07-04 Fengjiao Zhang, Renjie Zhang, Songgui He, Jingyi Guan, Zhaoxing Feng, Zhenqiang Wu
Abstract Soaking aged fat pork is a special aging process in the production of Chi-aroma Baijiu considered to involve the formation of free radicals. This study aimed to investigate the free radicals’ formation pathway in Chi-aroma Baijiu during aged fat pork soaking by using electron paramagnetic resonance (EPR) and spin trapping with 5,5-dimethyl-1-pyrrolin-n-oxide (DMPO). The alkyl radical adducts
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Generation and measurement of low-temperature plasma for cancer therapy: a historical review Free Radic. Res. (IF 3.3) Pub Date : 2023-07-04 Kenji Ishikawa, Keigo Takeda, Shinji Yoshimura, Takashi Kondo, Hiromasa Tanaka, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori
Abstract This review provides a description of the historical background of the development of biological applications of low-temperature plasmas. The generation of plasma, methods and devices, plasma sources, and measurements of plasma properties, such as electron dynamics and chemical species generation in both gaseous and aqueous phases, were assessed. Currently, direct irradiation methods for plasma
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Hydrogen peroxide activates APE1/Ref-1 via NF-κB and Parkin: a role in liver cancer resistance to oxidative stress Free Radic. Res. (IF 3.3) Pub Date : 2023-07-03 Ferbian Milas Siswanto, Kenta Okukawa, Akiyoshi Tamura, Ami Oguro, Susumu Imaoka
Abstract Cancer cells exhibit an altered redox balance and aberrant redox signaling due to genetic, metabolic, and microenvironment-associated reprogramming. Persistently elevated levels of reactive oxygen species (ROS) contribute to many aspects of tumor development and progression. Emerging studies demonstrated the vital role of apurinic/apyrimidinic endonuclease 1 or reduction/oxidation (redox)
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3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation Free Radic. Res. (IF 3.3) Pub Date : 2023-06-30 Narandulam Usukhbayar, Yukie Takano, Shota Uesugi, Makoto Muroi, Hiroyuki Osada, Ken-ichi Kimura
Abstract 3,6-Epidioxy-1,10-bisaboladiene (EDBD) is a bisabolane sesquiterpene endoperoxide that was isolated from an edible wild plant in Japan, Cacalia delphiniifolia. It showed partially apoptotic cell death through caspase activation against HL-60 cells. However, almost all of the cells had necrotic morphology. Thus, we examined the mechanism of action of EDBD on necrotic cell death. EDBD induced
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Untargeted metabonomic analysis of non-alcoholic fatty liver disease with iron overload in rats via UPLC/MS Free Radic. Res. (IF 3.3) Pub Date : 2023-06-28 Yang Shen, Xianan Li, Shichao Xiong, Shaoying Hou, Lijia Zhang, Li Wang, Xuezheng Dai, Yan Zhao
Abstract Background/Aims In recent years, many metabolites specific to nonalcoholic fatty liver disease (NAFLD) have been identified thanks to the application of metabolomics techniques. This study aimed to investigate the candidate targets and potential molecular pathways involved in NAFLD in the presence of iron overload. Methods Male Sprague Dawley rats were fed with control or high-fat diet with
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Mechanistic insight into the free radical scavenging and xanthine oxidase (XO) inhibitor potent of monoacetylphloroglucinols (MAPGs) Free Radic. Res. (IF 3.3) Pub Date : 2023-06-27 Wahyu Eko Prasetyo, Bram Tri Admojo, Triana Kusumaningsih, Soerya Dewi Marliyana, Fajar Rakhman Wibowo, Maulidan Firdaus
Abstract Three novel antioxidant candidates based on phenolic polyketide, monoacetylphloroglucinol (MAPG), a natural antibiotic compound produced by plant growth-promoting rhizobacteria (PGPR), Pseudomonas fluorescens F113 have been proposed. Initially, a green and highly efficient route to the synthesis of MAPG and its two analogues from phloroglucinol (PG) has been developed. Afterward, their rational
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Efficacy of periodic cold plasma treatment in a paddy to produce white-core grains in brewer’s rice cultivar Yamadanishiki Free Radic. Res. (IF 3.3) Pub Date : 2023-06-06 Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Yoji Hirosue, Masayoshi Maeshima, Masaaki Mizuno, Masaru Hori
Abstract We investigated the effect of cold plasma application on the yield and grain quality of rice (Oryza sativa L.), focusing on the brewer’s rice cultivar, Yamadanishiki. Two treatment methods were examined in a paddy; direct plasma irradiation of seedlings and indirect treatment with plasma-activated Ringer’s lactate solution (PAL) during the vegetative growth phase. Periodic direct irradiation
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Modified quantum mechanical approach for the estimation of single-electron reduction potential of nitroaromatic compounds in aqueous medium Free Radic. Res. (IF 3.3) Pub Date : 2023-05-21 Jelena Tamulienė, Benjaminas Valiauga, Narimantas Čėnas
Abstract The midpoint single-electron reduction potential of nitroaromatic compounds in aqueous medium at pH 7.0 (potential of ArNO2/ArNO2·– couple, Em7) frequently determines their therapeutic and/or toxic properties. However, its estimation remains a complex problem. We propose a modified method of Em7 estimation by quantum mechanical calculations, based on the use of the dielectric continuum model
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Hydroperoxyl radical (HOO•) as a reducing agent: unexpected synergy with antioxidants. A review Free Radic. Res. (IF 3.3) Pub Date : 2023-05-21 Andrea Baschieri, Zongxin Jin, Riccardo Amorati
Abstract This review highlights the progress made in recent years in harnessing the peculiar chemistry of the hydroperoxyl, or perhydroxyl, radical (HOO•) during lipid peroxidation, particularly with regard to its interaction with antioxidants. The HOO• radical, the protonated form of superoxide, plays an important role in the propagation and termination of lipid peroxidation in nonaqueous systems
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Effects of two- and twelve-weeks sodium-glucose cotransporter 2 inhibition on DNA and RNA oxidation: two randomized, placebo-controlled trials Free Radic. Res. (IF 3.3) Pub Date : 2023-05-19 Emil List Larsen, Andreas Andersen, Laura K. Kjær, Mie K. Eickhoff, Marie Frimodt-Møller, Frederik Persson, Peter Rossing, Jens Lykkesfeldt, Filip K. Knop, Tina Vilsbøll, Jørgen Rungby, Henrik E. Poulsen
Abstract Animal studies have shown that SGLT2 inhibition decreases oxidative stress, which may explain the cardiovascular protective effects observed following SGLT2 inhibition treatment. Thus, we investigated the effects of two and twelve weeks SGLT2 inhibition on DNA and RNA oxidation. Individuals with type 2 diabetes (n = 31) were randomized to two weeks of treatment with the SGLT2 inhibitor empagliflozin
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Trafficking of oxidative stress-generated lipid hydroperoxides: pathophysiological implications Free Radic. Res. (IF 3.3) Pub Date : 2023-05-16 Albert W. Girotti, Witold Korytowski
Abstract Lipid hydroperoxides (LOOHs) are reactive intermediates that arise during peroxidation of unsaturated phospholipids, glycolipids and cholesterol in biological membranes and lipoproteins. Non-physiological lipid peroxidation (LPO) typically occurs under oxidative stress conditions associated with pathologies such as atherogenesis, neurodegeneration, and carcinogenesis. As key intermediates
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Antioxidant and prooxidant modulation of lipid peroxidation by integral membrane proteins Free Radic. Res. (IF 3.3) Pub Date : 2023-04-19 Parvana Hajieva, Roman Abrosimov, Sascha Kunath, Bernd Moosmann
Abstract Lipid peroxidation is a biochemically adverse phenomenon with key involvement in many different diseases including premature infant blindness, nonalcoholic steatohepatitis, or Parkinson’s disease. Moreover, lipid peroxidation may be the most important universal driver of the biological aging process. Canonic lipid peroxidation is a free radical chain reaction consisting of three kinetically
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Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma Free Radic. Res. (IF 3.3) Pub Date : 2023-04-17 Camelia Miron, Kenji Ishikawa, Satoshi Kashiwagura, Yuki Suda, Hiromasa Tanaka, Kae Nakamura, Hiroaki Kajiyama, Shinya Toyokuni, Masaaki Mizuno, Masaru Hori
Abstract Cold atmospheric pressure plasmas are promising medical tools that can assist in cancer treatment. While the medical pathology mechanism is substantially understood, knowledge of the contribution of reactive species formed in plasma and the mode of activation of biochemical pathways is insufficient. Herein, we present a concept involving antitumoral plasma-activated organics, which is envisaged
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Free radical scavenging activity of gallic acid toward various reactive oxygen, nitrogen, and sulfur species: a DFT approach Free Radic. Res. (IF 3.3) Pub Date : 2023-04-03 Ankit Mittal, Vinod Kumar Vashistha, Dipak Kumar Das
Gallic acid is a well-recognized naturally occurring compound possessing antioxidant activities. The free radical scavenging ability of gallic acid for fifty reactive species, such as oxygen, nitro...
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Current understanding of plasma-activated solutions for potential cancer therapy Free Radic. Res. (IF 3.3) Pub Date : 2023-03-28 Nobuhisa Yoshikawa, Kae Nakamura, Hiroaki Kajiyama
Abstract Cancer therapy consists of multidisciplinary treatment combining surgery, chemotherapy, radiotherapy, and immunotherapy. Despite the elucidation of cancer mechanisms by comprehensive genomic and epigenomic analyses and the development of molecular therapy, drug resistance and severe side effects have presented challenges to the long-awaited development of new therapies. With the rapid technological
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Iron-loaded extracellular vesicles: angel or demon? Free Radic. Res. (IF 3.3) Pub Date : 2023-03-23 Huimin Chen, Yuhan Tang
Abstract Extracellular vesicles (EVs) are identified as a non-classical way to mediate iron efflux except ferroportin. Interestingly, recent studies indicated that EVs pathway is a novel way involved in iron efflux. Mitochondria-derived vesicles (MDVs) are the potential mediator to load mitochondrial iron into EVs. Additionally, iron-replete cells resist excess iron-induced damage by secreting iron-loaded
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Hypoxia induces dichotomous and reversible attenuation of T cell responses through reactive oxygen species-dependent phenotype redistribution and delay in lymphoblast proliferation Free Radic. Res. (IF 3.3) Pub Date : 2023-03-22 Dharmendra Kumar Maurya, Deepak Sharma, Santosh Kumar Sandur
Abstract As T cells transit between blood, lymphoid organs, and peripheral tissues, they experience varied levels of oxygen/hypoxia in inflamed tissues, skin, intestinal lining, and secondary lymphoid organs. Critical illness among COVID-19 patients is also associated with transient hypoxia and attenuation of T cell responses. Hypoxia is the fulcrum of altered metabolism, impaired functions, and cessation
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FOXO signaling pathway participates in oxidative stress-induced histone deacetylation Free Radic. Res. (IF 3.3) Pub Date : 2023-03-22 Mengna Zuo, Ruiying Tong, Xiaoying He, Yang Liu, Jiwei Liu, Shujun Liu, Ying Liu, Junwei Cao, Libing Ma
Abstract High concentrations of antioxidants can exert pro-oxidative effects, elevate the level of intracellular reactive oxygen species (ROS), and cause oxidative stress in cells. We previously found that high concentrations of curcumin, a natural polyphenol antioxidant, elevated ROS levels and upregulated the expression of histone deacetylase 1 (HDAC1) in human gastric cancer cells (hGCCs); however
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Low-temperature plasma as magic wand to differentiate between the good and the evil Free Radic. Res. (IF 3.3) Pub Date : 2023-03-22 Shinya Toyokuni, Hao Zheng, Yingyi Kong, Kotaro Sato, Kae Nakamura, Hiromasa Tanaka, Yasumasa Okazaki
Abstract Plasma is the fourth physical state of matter, characterized by an ionized gaseous mixture, after solid, liquid, and gas phases, and contains a wide array of components such as ions, electrons, radicals, and ultraviolet ray. Whereas the sun and thunder are typical natural plasma, recent progress in the electronics enabled the generation of body-temperature plasma, designated as low-temperature
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Growth acceleration of Nile tilapia at 21 to 31 weeks of age with plasma-treated air-supplied water Free Radic. Res. (IF 3.3) Pub Date : 2023-03-20 Yoshihisa Ikeda, Ryo Fukushima, Kazuki Tange, Hideki Motomura, Taiju Saito, Masafumi Jinno
Abstract This study aimed to develop a technique to accelerate fish growth without using genetic modification or genome editing. We have prepared a reactor with four pairs of opposed electrodes and a high-voltage power supply for the discharge. An arc discharge generates a plasma-treated gas in the reactor. Plasma-treated gas containing active species such as nitric oxide (NO) was generated via an
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Exposure of low-temperature plasma after vaccination in tongue promotes systemic IgM induction against spike protein of SARS-CoV-2 Free Radic. Res. (IF 3.3) Pub Date : 2023-03-20 Kotaro Sato, Kouki Fujii, Hiromasa Tanaka, Masaru Hori, Hideharu Hibi, Shinya Toyokuni
Abstract COVID-19 has been pandemic since 2020 with persistent generation of new variants. Cellular receptor for SARS-CoV-2 is angiotensin-converting enzyme 2 (ACE2), where transmembrane serine protease-2 (TMPRSS2) is essential for viral internalization. We recently reported abundant expression of ACE2 and TMPRSS2 in the oral cavity of humans and mice. Therefore, oral cavity may work for COVID-19 infection
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Plasma activated Ringer’s lactate solution Free Radic. Res. (IF 3.3) Pub Date : 2023-03-01 Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron, Yasumasa Okazaki, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Masaru Hori
Abstract Low-temperature plasma (LTP) has been widely used in life science. Plasma-activated solutions were defined as solutions irradiated with LTP, and water, medium, and Ringer’s solutions have been irradiated with LTP to produce plasma-activated solutions. They contain chemical compounds produced by reactions among LTP, air, and solutions. Reactive oxygen and nitrogen species (RONS) are major components
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Assessment of antioxidant and antiparkinsonian potential of a new diterpene isolated from Croton argyrophylloides Free Radic. Res. (IF 3.3) Pub Date : 2023-02-22 Rafael Carneiro Bastos, Carlos Franciney Moreira Vasconcelos, Marcela Bezerra Paiva, Thomas Dominik de Sousa dos Reis, Ricardo Basto Souza, Hélcio Silva dos Santos, Paulo Nogueira Bandeira, Lissiana Magna Vasconcelos Aguiar, Rodrigo Maranguape Silva da Cunha
Abstract Oxidative stress is related to health problems including neurological and neurodegenerativedisturbs, such as Parkinson’s disease. Natural compounds are reported as source of antioxidant molecules. Therefore, this study aimed to analyze the antioxidant and neuroprotective potential of a new diterpene isolated from C. argyrophylloides (MP-1). Male Wistar rats (250–300 g) were used to evaluate
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Transferrin-mediated increase of labile iron Pool following simulated ischemia causes lipid peroxidation during the early phase of reperfusion Free Radic. Res. (IF 3.3) Pub Date : 2023-02-15 Dongju Lee, Euncheol Son, Young-Hoon Kim
Abstract Heart ischemia/reperfusion (I/R) injury is related to iron content. However, the occurrence and mechanism of changes in labile iron pool (LIP) during I/R is debatable. Moreover, the identity of the iron form dominant in LIP during I/R is unclear. Herein, we measured changes of LIP during simulated ischemia (SI) and reperfusion (SR), in which ischemia was simulated in vitro with lactic acidosis
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Autoxidation of ascorbate mediates lysine N-pyrrolation Free Radic. Res. (IF 3.3) Pub Date : 2023-02-07 Jun Yoshitake, Takahiro Shibata, Miho Chikazawa, Koji Uchida
Abstract Protein N-pyrrolation, which converts lysine residues to Nε-pyrrole-l-lysine (pyrK), is a naturally occurring covalent modification. The pyrrolated proteins have a unique property of binding to DNA-staining agents, such as SYBR Green I (SG), and anti-DNA antibodies, suggesting a physiologically relevant modification that gives rise to DNA mimic protein. These properties of pyrrolated protein
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Decreased plasma H2O2 levels are associated with the pathogenesis leading to COVID-19 worsening and mortality Free Radic. Res. (IF 3.3) Pub Date : 2023-02-01 Liara Freitas Cavalcanti, Isabela Chagas Silva, Thiago Henrique Daniel do Nascimento, Jôse de Melo, Cintia Magalhães Carvalho Grion, Alessandra Lourenço Cecchini, Rubens Cecchini
Abstract Oxidative Stress (OS) is involved in the pathogenesis of COVID-19 and in the mechanisms by which SARS-CoV-2 causes injuries to tissues, leading to cytopathic hypoxia and ultimately multiple organ failure. The measurement of blood glutathione (GSH), H2O2, and catalase activity may help clarify the pathophysiology pathways of this disease. We developed and standardized a sensitive and specific
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Guaiacol oxidation: theoretical insight into thermochemistry of radical processes involving methoxy group demethylation Free Radic. Res. (IF 3.3) Pub Date : 2023-01-26 Monika Biela, Andrea Kleinová, Erik Klein
Abstract Guaiacol (2-methoxyphenol) is naturally occurring phenolic compound essential in various research areas. Oxidative transformation of guaiacol can lead to the formation of various products, including 1,3-benzodioxole or ortho-quinone. Therefore, this study is focused on the investigation of the reaction enthalpies of experimentally observed guaiacol oxidation pathways in gas-phase, as well
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Urinary 8-oxoGuo as a potential novel evaluation index for patients with nephrotic syndrome Free Radic. Res. (IF 3.3) Pub Date : 2023-01-16 Zhen Liu, Jing-Jing Wang, Qian Liu, Jin Li, Shan Jiang, Ya-Qing Ma, Ya-Min Dang, Jian-Ping Cai
Abstract Urinary 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2′- deoxyguanosine (8-oxodGuo) are considered biomarkers of oxidative stress, and patients with nephrotic syndrome have been reported to have increased oxidative stress levels. In this study, we aimed to assess the value of 8-oxoGuo and 8-oxodGuo as novel biomarkers to evaluate the severity of nephrotic syndrome. In total