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Robust and versatile assembly for emitter positioning, observation, and heating in atmospheric pressure field desorption mass spectrometry Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2024-03-15 Jan Schweinfurth, H. Bernhard Linden, Jürgen H. Gross
Atmospheric pressure field desorption (APFD) mass spectrometry (MS) has recently been introduced as a new variant of field desorption (FD) mass spectrometry. The development aimed at providing the basic characteristics of FD-MS in combination with instruments equipped with an atmospheric pressure (AP) interface. Hitherto, APFD has been demonstrated to yield both positive and negative even electron
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Teaching mass spectrometry: A compilation of approaches to teaching theory and practice of mass spectrometry Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2024-03-06 Rafał Frański
The areas of mass spectrometry applications seem to be much larger than those of any other analytical techniques. They extend from the determination of molecular mass in organic chemistry, through the analytical applications in forensic, environmental and omics sciences, the application in extra-terrestrial exploration and many others. Mass spectrometry, usually coupled with chromatographic techniques
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Structure analysis of depsides, dibenzofuran and sugar derivatives from Cladia aggregata (SW) Nyl using ultra-performance liquid chromatography–tandem mass spectrometry Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2024-02-07 Priyanka Rawat, Sajan Lal Shyaula, Yatendra Singh, Sanjeev Kanojiya
Cladia aggregate (SW) Nyl is a lichenized fungi in the family Cladoniaceae producing characteristic secondary metabolites of interest. There are only limited chemical studies relating to the genus Cladia. A chemical study of the lichen C. aggregata was conducted and their chemical constituents were elucidated by ultra-performance liquid chromatography−electrospray ionization/triple-quadrupole tandem-mass
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Quantification of derivatized phenylalanine and tyrosine in dried blood spots using liquid chromatography with tandem spectrometry for newborn screening of phenylketonuria Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2024-02-07 Tsai-Hui Duh, Yu-Ching Liang, Po Tsun Shen, Yi-Wen Ke, Yan-Tian Nian, Shih-Shin Liang
Phenylketonuria (PKU) is an autosomal genetic disorder caused by a deficiency of the phenylalanine hydroxylase (PAH) enzyme. The lack of PAH results in the inability of phenylalanine (PHE) to transform into tyrosine (TYR). Consequently, this leads to the accumulation of PHE in the blood samples of newborns causing metabolic diseases such as irreversible neurological problems. An analysis was required
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Evaluation of SP3 for antibody-free quantification of tau in CSF mimic and brain by mass spectrometry Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2024-01-23 Chloé Jacquemin, Nicolas Villain, Rita Azevedo, Susana Boluda, Etienne A. Thévenot, François Fenaille, Foudil Lamari, François Becher
Tubulin-associated unit (tau) has an important role in the pathogenesis and the diagnosis of Alzheimer's disease (AD) and other tauopathies. In view of the diversity of tau proteoforms, antibody-free methods represent a good approach for unbiased quantification. We adapted and evaluated the single-pot, solid-phase-enhanced sample-preparation (SP3) protocol for antibody-free extraction of the tau protein
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Simultaneous quantification of tiotropium bromide impurities G + H in capsule formulation by LC-MS/MS. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-11-30 Serdar Erkol,Müge Güleli,Cem Çalışkan,Sevgi Kocaoba
Tiotropium Bromide is a long-acting bronchodilator that is used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma bronchodilator or bronchiolitis, which are substances that expand the bronchi and reduce resistance in the respiratory tract and increase airflow to the lungs. For Tiotropium Bromide found in inhaler capsules to treat COPD, determining the relevant impurities G
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Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-11-17 J Stuart Grossert,Donatella Boschi,Marco L Lolli,Robert L White
Gas phase fragmentation reactions of monoprotonated 4-(3-aminopropyl)- and 4-(4-aminobutyl)-3-hydroxyfurazan were investigated to examine potential interactions between functional groups. The two heterocyclic alkyl amines were ionized by electrospray ionization (ESI, positive mode) and fragmented using tandem mass spectrometry (MS/MS). The fragmentation pathways were characterized using pseudo MS3
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Epitope characterization of proteins and aptamers with mass spectrometry. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-11-13 Loredana Lupu,Wolfgang Kleinekofort,Nina Morgner
The way in which professor Michael Przybylski has combined the spirit of research with entrepreneurship has set an example for any and all scientists. He has made significant achievements in the fields of mass spectrometry, biochemistry and medicine, and has initiated important technological developments in the area of protein analysis. Between 2016 and 2023 professor Przybylski's scientific focus
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Method for determination of elemental impurities in metronidazole benzoate using inductively coupled plasma mass spectrometry. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-11-05 Maoxian Tian,Hui Zhang,Huajun Fan,Mingxing Yin,Wenqing Wang,Chunyang Shi
The elemental impurities in pharmaceutical products have aroused widespread concern among respective supervising authorities and official pharmacopoeias since they are harmful and have no therapeutic effects. Metronidazole benzoate is used extensively to treat a variety of infections. However, impurities will inevitably be introduced in the manufacturing process of metronidazole benzoate. Hence, in
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Coordination and fragmentation chemistry of CyMe4-BTPhen complexes with lanthanides and actinides: A combined investigation by ESI-MS and DFT calculations. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-10-09 Qiqi Zhang,Yang Liu,Shuping Tan,Yan Chen,Xinyue Liang,Weiqun Shi,Yonggang Zhao
To further understand the complexation and fragmentation during the extraction process, the formation of 2,9-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-12,4-benzotriazin-3-yl)-1,10-phenanthroline (CyMe4-BTPhen) complexes with lanthanides (Ln = La, Ce, Nd, Sm, Eu, Yb) and actinides (UO22+, Th4+) was observed by electrospray ionization mass spectrometry (ESI-MS) technique and density functional theory
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Instrumentation development, improvement, simplification, and miniaturization: The multifunctional plate source for use in mass spectrometry. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-10-01 Sarah Trimpin,Ellen Inutan,Hope Coffinberger,Khoa Hoang,Frank Yenchick,James Wager-Miller,Milan Pophristic,Ken Mackie,Charles N McEwen
In remembrance of Prof. Dr Przybylski, we are presenting a vision towards his beloved mass spectrometry (MS) and its far-reaching promises outside of the academic laboratory. Sub-atmospheric pressure (AP) ionization MS is well positioned to make a step-change in direct ionization, a concept that allows sublimation/evaporation ionization and mass analyses of volatile and nonvolatile molecules from clean
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Toward a MALDI in-source decay (ISD) method for top-down analysis of protein footprinting. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-09-26 Ruidong Jiang,Don L Rempel,Michael L Gross
Irreversible protein footprinting is a mass spectrometry-based approach in which solvent-accessible sites of a protein are modified to assess high-order protein structure. Structural insights can be gained by determining the position and extents of modification. The usual approach to obtain the "footprint" is to analyze the protein through bottom-up LC-MS/MS. In this approach, the proteins are digested
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Top-down mass spectrometry for characterizing the low molecular weight proteome of canine osteosarcoma cell phenotypes. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-09-19 Liping Yang,Stanislau Stanisheuski,Zifeng Song,Shay Bracha,Claudia S Maier
Osteosarcoma (OS) is the most common primary malignant tumor of bone, which occupying about 20% of all bone cancers. To increase understanding of the biology of OS, we developed and evaluated a top-down mass spectrometry approach to detect, identify and quantify low molecular weight (MW) proteins (i.e., 1 kDa < MW < 30 kDa) in osteosarcoma cells. Top-down proteomic (TDP) data was acquired using reversed
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Epitope identification of a Lys63 linkage ubiquitin antibody by mass spectrometric epitope excision and extraction approaches. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-09-19 Ji Eun Jung,Vanessa Cárdenas,Brîndușa Alina Petre
Ubiquitin, a conserved protein in eukaryotic cells, exists as a monomer or polyubiquitin chains known as isopeptide-linked polymers. These chains are attached to a substrate or other ubiquitin molecules through a covalent bond between the α-amino group of lysine in ubiquitin and glycine in the C-terminal of the subsequent ubiquitin unit. The choice of the specific lysine residue in ubiquitin for forming
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Lyso-phosphatidylethanol detected by LC-MS/MS as a potential new marker for alcohol consumption. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-09-14 Matthias Bantle,Lanya van Tieghem,Wolfgang Weinmann,Marc Luginbühl
Alcohol biomarkers are able to reflect the degree of recent or long-term alcohol consumption, covering different windows of detection. Phosphatidylethanols (PEths) are an emerging group of direct alcohol biomarkers that are widely applied in clinical and forensic applications. Their quantification can provide insight into an individual's drinking behaviour. Here, we present a new sub-class of yet unknown
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Identification of human hexahydrocannabinol metabolites in urine. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-09-14 Willi Schirmer,Volker Auwärter,Julia Kaudewitz,Stefan Schürch,Wolfgang Weinmann
Hexahydrocannabinol (HHC) is a cannabinoid that has been known since 1940 but has only recently found its way into recreational use as a psychoactive drug. HHC has been used as a legal alternative to tetrahydrocannabinol (THC) in many countries, but first countries already placed it under their narcotic substances law. Our aim was to evaluate a reliable analytical method for the proof of HHC consumption
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Mass spectrometry as a lens into molecular human nutrition and health. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-08-16 Martin Kussmann
Mass spectrometry (MS) has developed over the last decades into the most informative and versatile analytical technology in molecular and structural biology (). The platform enables discovery, identification, and characterisation of non-volatile biomolecules, such as proteins, peptides, DNA, RNA, nutrients, metabolites, and lipids at both speed and scale and can elucidate their interactions and effects
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Sensitive and rapid quantitation of dexamethasone in human plasma using liquid chromatography coupled with triple quadrupole mass spectrometer. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-08-15 Naveen Kumar Dubey,Peeyush Jain
The aim of this paper was to develop, validate, and utilize a sensitive liquid chromatography-tandem mass spectrometry bioanalytical method for bioequivalence/clinical trial studies conducted in human plasma. To accomplish the target, a stable labeled internal standard, that is, dexamethasone D4 was used as an internal standard to track and compensate the parent compound during processing, and extraction
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Identification and characterization of stress degradation products of ibrutinib by LC-UV/PDA and LC-Q/TOF-MS studies. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-08-01 Bidisha Mondal,Alka Bali,Tanvi Sharma
The anticancer drug ibrutinib was subjected to stress degradation studies under the ICH-prescribed hydrolytic, photolytic, oxidative and thermal stress conditions, and its degradation behavior was studied. A significant degradation was noted for the drug under acidic/alkaline hydrolytic, acid/alkaline photolytic, and oxidative conditions. The UPLC-UV/PDA studies revealed the generation of six degradation
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Long-term in situ air quality assessment in closed environments: A gas chromatography-ion mobility spectrometry applicability study. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-07-13 Pedro Catalão Moura,Valentina Vassilenko
Contemporary life is mostly spent in indoor spaces like private houses, workplaces, vehicles and public facilities. Nonetheless, the air quality in these closed environments is often poor which leads to people being exposed to a vast range of toxic and hazardous compounds. Volatile organic compounds (VOCs) are among the main factors responsible for the lack of air quality in closed spaces and, in addition
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Hammett correlation in competition experiments in dissociation of ionised substituted benzophenones and dibenzylideneacetones. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-07-05 Nathan W Fenwick,Richard Telford,William H C Martin,Richard D Bowen
A convenient method of applying competition experiments to devise a Hammett correlation in the dissociation by α-cleavage of 17 ionised 3- and 4-substituted benzophenones, YC6H4COC6H5 [Y=F, Cl, Br, CH3, CH3O, NH2, CF3, OH, NO2, CN and N(CH3)2] is reported and discussed. The results given by this approach, which rely on the relative abundance of [M-C6H5]+ and [M-C6H4Y]+ ions in the electron ionisation
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Development and validation of a simple microwave-assisted digestion sample preparation technique for the estimation of aluminium and magnesium in a few pharmaceutical dosage forms by an inductively coupled-mass spectrometer (ICP-MS). Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-06-28 Ashish Kumar Pal,Raja Sundararajan
Rationale: A simple, sensitive, reliable, validated, inductively coupled plasma mass spectrometric method for the determination of aluminium and magnesium using a simple common microwave-assisted digestion sample preparation technique for a few commonly used formulations was developed and validated according to International Conference on Harmonization Q3D and the United States Pharmacopeia general
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Protonation of gabapentin: Ion mobility spectrometry and computational study. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-06-26 Manijeh Tozihi,Hamed Bahrami,Mohammadreza Zarifian,Morteza Vahedpour
Protonation of gabapentin was studied using corona discharge ion mobility spectrometry with two types of reactant ions at temperature of 200°C. It was found that at elevated temperatures, ionization of gabapentin proceeds via two channels, including the protonation and reactant ion attachment, in the presence of both hydronium and ammonium reactant ions. The effect of the sample concentration on the
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Dynamic changes of serum metabolite profiling in septic mice based on high performance liquid chromatography of quadrupole time of flight mass spectrometry analysis. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-06-20 Shutong Li,Qi Zeng,Shentang Li,Yarong Liu,Yang Feng,Fang Chen,Lianhong Zou,Xiehong Liu,Yanjuan Liu,Yu Jiang
The objective of this study is to gain insights into the underlying metabolic transformations that occurred during the whole progression of cecal ligation and puncture (CLP)-induced sepsis, thus providing new targets for its treatment. High-performance liquid chromatography of quadrupole time of flight mass spectrometry (HPLC-Q-TOF-MS/MS) combined with multivariate statistical techniques was used to
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Liquid chromatography separation and identification of new oxidative degradation impurity in edoxaban tosylate hydrate drug substance by using liquid chromatography with tandem mass spectrometry. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-06-12 Chandramohan Alluri,G Veera Raghava Sharma
Edoxaban is an anti-coagulant medication and a director factor Xa inhibitor. A novel reverse phase liquid chromatography-mass spectrometry compatible method developed for separation and identification of new oxidative degradation impurities in edoxaban tosylate hydrate drug substance. The separation of three oxidative degradation impurities was achieved by using YMC Triart phenyl (250 × 4.6) mm,
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A HPLC-MS/MS method for the determination of Nadolol in rat plasma: Development, validation, and application to pharmacokinetic study. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-06-12 Narasimha Kanjarla,Bhuvanachandra Pasupuleti,Narender Boggula,Praveen K Kusuma,Daniel Kothapally,Vamshikrishna Gone,Gangarapu Kiran
A sensitive validated method has been developed for the quantification of Nadolol in rat plasma by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) using deuterated Nadolol (Nadolol D9) as internal standard (IS). The liquid-liquid extraction method using ethyl acetate was employed for the sample pretreatment. The separation was achieved on the Agilent Zorbax
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Measurement of vitamin K and its derivatives in human plasma through enzyme-assisted liquid chromatography-tandem mass spectrometry assay. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-06-12 Metin Demirel,Sahabettin Selek
Vitamin K is an essential lipophilic vitamin that acts as a coenzyme in several metabolic pathways. Accurate measurement of apolar metabolites transported by lipoproteins in serum matrices requires high-recovery extractions of vitamin K and its derivatives following standardized protocols. Conventionally developed methods in this field have predominantly employed solid-phase extraction for the measurement
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Native and compactly folded in-solution conformers of pepsin are revealed and distinguished by mass spectrometric ITEM-TWO analyses of gas-phase pepstatin A - pepsin complex binding strength differences. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-05-31 Cornelia Koy,Ursula M Glocker,Bright D Danquah,Michael O Glocker
Pepsin, because of its optimal activity at low acidic pH, has gained importance in mass spectrometric proteome research as a readily available and easy-to-handle protease. Pepsin has also been study object of protein higher-order structure analyses, but questions about how to best investigate pepsin in-solution conformers still remain. We first determined dependencies of pepsin ion charge structures
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Gas chromatography–mass spectrometric determination of bisphenol residues by dispersive solid phase extraction followed by activated carbon spheres cleanup from fish feed samples Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-05-15 Kalpana Talari, Sai Krishna Ganji, Raja Rajeswari Tiruveedula
Bisphenols are known endocrine disruptors commonly utilized in food packaging and storage materials, which frequently come into touch with multiple food products packed in them. The bisphenols in f...
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A pattern-recognition-based clustering method for non-invasive diagnosis and classification of various gastric conditions. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-05-16 Abhijit Maity,Sayoni Bhattacharya,Anil C Mahato,Sujit Chaudhuri,Manik Pradhan
Conventional endoscopic biopsy tests are not suitable for early detection of the acute onset and progression of peptic ulcer as well as various gastric complications. This also limits its suitability for widespread population-based screening and consequently, many people with complex gastric phenotypes remain undiagnosed. Here, we demonstrate a new non-invasive methodology for accurate diagnosis and
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Prof. Dr Michael Przybylski (* 25.3.1948; † 27.2.2023). Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-04-01 Jürgen Grotemeyer
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Exploratory data fusion of untargeted multimodal LC-HRMS with annotation by LCMS-TOF-ion mobility: White wine case study Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-03-21 Mpho Mafata, Maria Stander, Keabetswe Masike, Astrid Buica
Applied sciences have increased focus on omics studies which merge data science with analytical tools. These studies often result in large amounts of data produced and the objective is to generate ...
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Quantitation of small molecules from liquid chromatography—mass spectrometric accurate mass datasets using CycloBranch Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-03-20 Jiří Novák, Kevin A Schug, Vladimír Havlíček
Gaussian and exponentially modified Gaussian functions were incorporated into integrating algorithms used by an open-source, cross-platform tool called CycloBranch. The quantitation is demonstrated...
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The analytical solution for the optimum voltage on regularizing electrodes of the open dynamically harmonized cell Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-03-15 Anton Lioznov, Evgeny Nikolaev
The Fourier transform ion cyclotron resonance method holds the lead in mass accuracy and resolving power among all other mass spectrometry methods. The dynamically harmonized cell is largely respon...
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Insight into in silico prediction and chemical degradation study of osimertinib mesylate by LC-HRMS and NMR: Investigation of a typical case of alkaline pH-mediated oxidative degradation product Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-03-09 Vivek Dhiman, Balasaheb B. Chavan, Niharika Ramarapu, Gananadhamu Samanthula
Osimertinib mesylate is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor used to treat nonsmall-cell lung cancer. The objective was to understand in silico prediction a...
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Proximity effects in the electron ionisation mass spectra of substituted cinnamamides Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-02-16 Adam R Michalik, Nathan W Fenwick, Richard Telford, Archie W Johnson, William HC Martin, Richard D Bowen
The electron ionisation mass spectra of an extensive set of 53 ionised monosubstituted and disubstituted cinnamamides [XC6H4CH=CHCONH2, X = H, F, Cl, Br, I, CH3, CH3O, CF3, NO2, CH3CH2, (CH3)2CH an...
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Rapid detection of serum free light chains by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-02-03 Zelal Zuhal Kaya, Muhittin Serdar, Fehime Aksungar, Meltem Kilercik, Mustafa Serteser, Ahmet Tarik Baykal
Introduction: Serum free light chain (FLC) measurements are increasingly prominent for patients with plasma cell disorders (PCDs) in screening, prognostic stratification, and monitoring therapy res...
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Synthesis, characterization, and liquid injection field desorption ionization mass spectrometry analysis of pincer ligated group 6 (Cr, Mo, W) carbonyl complexes Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-01-17 Olivia L. Duletski, Navamoney Arulsamy, Michael T. Mock
We report the synthesis of molybdenum and tungsten bromo dicarbonyl complexes (POCOPtBu)MIIBr(CO)2 (M = Mo or W; POCOPtBu = κ3-C6H3-1,3-[OP(tBu)2]2) supported by an anionic PCP pincer ligand, a...
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Unprecedented intact radical anions, closed shell anions, cluster ions, and traditional cations and radical cations by LIFDI–MS Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2023-01-05 Mathias H. Linden, H. Bernhard Linden
Liquid injection field desorption ionization (LIFDI) proves the extraordinary softness of the ionization process combined with a convenient sample supply under the exclusion of moisture and air. LI...
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Liquid injection field desorption/ionization as a powerful tool to characterize volatile, labile, and reactive metal–organic complexes Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-12-29 Nils Boysen, Anjana Devi
Electron ionization mass spectrometry (EI-MS) is often used to characterize volatile and thermally stable organometallic complexes relevant for chemical vapor deposition (CVD) processes. However, t...
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Guest Editorial: Two Decades of LIFDI: Pedigree and Capabilities. Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-12-25 H Bernhard Linden
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Flash pyrolysis vacuum ultraviolet photoionization mass spectrometry of cycloheptane: A study of the initial decomposition mechanism Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-12-05 Kuanliang Shao, Ge Sun, Mariah Gomez, Xinghua Liu, Jingsong Zhang
Thermal decomposition of cycloheptane was studied using flash pyrolysis coupled with vacuum ultraviolet (118.2 nm) single photon ionization time-of-flight mass spectrometry at temperatures ranging ...
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Group 6 germylidyne complexes in the gas phase by LIFDI and APCI mass spectrometry Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-11-28 Leonard R. Maurer, Marianne Engeser
Although showing fascinating chemical properties and reactivity in solution, heavier tetrelylidyne complexes with M≡E triple bonds have not been studied in the gas phase before due to their high se...
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Mass spectrometric detection of ion pairs containing rigid copper clusters and weakly coordinating counter ions using liquid injection field desorption/ionisation Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-11-28 Julia Taubert, Matthias Vogt, Robert Langer
A comparative mass spectrometric investigation using electrospray ionisation (ESI) and liquid injection field desorption/ionisation (LIFDI) techniques is reported for the highly luminescent and cat...
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Identification and characterization of selected silyl substituted silyl anions by liquid injection field desorption ionization mass spectrometry Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-11-17 Thomas Lainer, Roland C Fischer, Michael Haas
Silyl anions are crucial building blocks in silicon chemistry and are frequently used in organosilicon chemistry. These so-called silanides are negatively charged three-coordinate species, isoelect...
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Mass-spectrometric studies of kinetic characteristics of codeine molecule thermodesorption by non-stationary surface ionization method Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-11-01 GT Rakhmanov, DT Usmanov
The adsorption and surface ionization of codeine molecules С18H21O3N (m/z 299) on the surface of oxidized tungsten have been studied by a non-stationary method of voltage modulation under the same ...
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Desorption of positive and negative ions from activated field emitters at atmospheric pressure Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-10-18 Jürgen H. Gross
Field desorption (FD) traditionally is an ionization technique in mass spectrometry (MS) that is performed in high vacuum. So far only two studies have explored FD at atmospheric pressure or even s...
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Positive + negative is not equal to zero: Use of negative ionisation as analyte identity confirmation tool in LC-ESI-MS analysis Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-10-06 Ernesto Zapata, Ivo Leito, Koit Herodes
In this study the use of negative electrospray ionisation mode as a confirmation tool for identifying derivatized amino acids using LC-ESI-MS, was evaluated. The derivatization reagent was based on...
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Gas Chromatography – Ion Mobility Spectrometry as a tool for quick detection of hazardous volatile organic compounds in indoor and ambient air: A university campus case study Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-10-05 Pedro Catalão Moura, Valentina Vassilenko
Society’s concerns about the citizens’ exposure to possibly dangerous environments have recently risen; nevertheless, the assessment of indoor air quality still represents a major contemporary chal...
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Differential ionization cross-section of hydrogen bromide Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-09-28 Ritu Sharawat, Meenakshi Kumari, Rajeev Kumar, Ravinder Sharma
In this study, the relative single and double differential ionization cross-section of the hydrogen bromide molecule and their fragmented ions (HBr+, Br+, H+) have been theoretically evaluated. In ...
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Quantitative evaluation and pharmacokinetic characteristics of the irreversible BTK inhibitor zanubrutinib in mouse plasma using LC-MS/MS Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-09-22 Kai Cheng, Junsong Wei, Jianrong Kou, Huining You, Min Li, Weiyi Feng
Zanubrutinib (BGB-3111) belongs to the class of irreversible inhibitors of Bruton's tyrosine kinase (BTK) for treating B-cell malignancies. A validated assay with excellent sensitivity, selectivity...
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A simple UPLC-MS/MS assay with a core-shell column for the determination of exemestane in human plasma for clinical application Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-09-21 Takuho Ishii, Nana Nojiri, Yuji Mano
Exemestane is one of the aromatase inhibitors and has been used to treat breast cancer by lowering estrogen levels. Accurate quantification of exemestane is important to set an optimal dose, and th...
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Bioanalytical method for estimation of procyclidine in human plasma using liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-07-03 Viritha Bezawada, Padma Mogili, Sireesha Dodda, Ramakrishna Gajula
A rapid, selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for quantification of procyclidine hydrochloride in human plasma using ...
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Gas chromatography-mass spectrometric determination of organic acids by ion pair liquid extraction followed by in-situ butylation from aqua feed samples Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-06-23 Kalpana Talari, Sai Krishna Ganji, Satish Mutyam, Raja Rajeswari Tiruveedula
A rapid and sensitive analytical method was developed to quantitatively determine organic acids (OAs) from fish feed samples extracted by ion-pair (IP) solvent extraction, followed by in-situ butyl...
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Sample preparation and quantification of polar drug, allopurinol, in human plasma using LCMSMS Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-06-06 Emily Yii Ling Wong, Gabriel Onn Kit Loh, Chen Zhu Goh, Yvonne Tze Fung Tan, Sharon Shi Min Ng, Kian Boon Law, Kit Yee Cheah, Hani Farhana Mohd, Kok Khiang Peh
A fast, selective and reproducible LC-MS/MS method with simple sample preparation was developed and validated for a polar compound, allopurinol in human plasma, using acyclovir as internal standard...
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Determination of arsenic, cadmium, mercury, lead and nickel as elemental impurities in atorvastatin calcium by inductively coupled mass spectrometer Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-06-03 Ashish Kumar Pal, Raja Sundararajan
Atorvastatin calcium is employed as front-line treatment for cardiovascular diseases. According to the international conference on harmonization (ICH) guideline ICH Q3D, elemental impurities can co...
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Fragmentation analysis of O-specific polysaccharide from bacteria Vibrio cholerae O139 by MALDI-TOF and LC/ESI-MS/MS Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-05-06 Filip Pančík, Zuzana Pakanová, Jana Mečárová, Alžbeta Čížová, Slavomír Bystrický, Stanislav Kozmon, Peter Baráth
Cholera is a life-threatening diarrhoeal disease caused by ingestion of Vibrio cholerae. There are at least 200 serogroups of V. cholerae but only two of them are causing epidemics – O1 and O139 se...
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GC-MS based metabolite fingerprinting of serous ovarian carcinoma and benign ovarian tumor Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-05-03 Evren Caglar Eroglu, Umran Kucukgoz Gulec, Mehmet Ali Vardar, Semra Paydas
The aim of this study is to identify urinary metabolomic profile of benign and malign ovarian tumors patients. Samples were analyzed using gas chromatography-mass spectrometry (GC-MS) and metabolom...
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Liquid biopsy markers for early diagnosis of brain metastasis patients with breast cancer by metabolomics Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-04-14 Özge Özer, Emirhan Nemutlu, Tuba Reçber, Cemil Can Eylem, Burak Yasin Aktas, Sedef Kır, Ayse Kars, Sercan Aksoy
Introduction: Breast cancer is the most common cancer in women and is the second most common cause of cancer related mortality. Metabolomics, the identification of small metabolites, is a technique...
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Modeling dipolar excitation for quadrupole mass filter Eur. J. Mass Spectrom. (IF 1.3) Pub Date : 2022-03-30 AN Konenkov, NV Konenkov, AA Sysoev
The results of modeling AC and DC dipole excitation of ion oscillations in a quadrupole mass filter are presented. The simulation is done by numerical integration of the ion motion equations, ions’...