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Application of nanoformulations as a strategy to optimize chemotherapeutic treatment of glioblastoma: a systematic review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2024-03-13 Victor Alves de Oliveira, Helber Alves Negreiros, Igor Gabriel Barbosa de Sousa, Layza Karyne Farias Mendes, João Pedro Alves Damaceno Do Lago, Athanara Alves de Sousa, Taline Alves Nobre, Irislene Costa Pereira, Felipe Cavalcanti Carneiro da Silva, Janildo Lopes Magalhães, João Marcelo de Castro e Sousa
The aim of this review was to explore the advances of nanoformulations as a strategy to optimize glioblastoma treatment, specifically focusing on targeting and controlling drug delivery systems to ...
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Dermal absorption of cyclic and linear siloxanes: a review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2024-02-20 Harvey Clewell, Tracy Greene, Robinan Gentry
Cyclic and linear siloxanes are compounds synthesized from silicon consisting of alternating atoms of silicone and oxygen [Si-O] units with organic side chains. The most common cyclic siloxanes are...
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Occupational exposure to endotoxins and small cell lung cancer: a systematic review with meta-analysis J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2024-02-18 Nerea Mourino, Leonor Varela-Lema, Alberto Ruano-Ravina, Cristina Peiteado, Cristina Candal-Pedreira, Julia Rey-Brandariz, Eliana Torres-Cadavid, Guadalupe García, Mónica Pérez-Ríos
The relationship of occupational exposure to endotoxins with different histologic subtypes of lung cancer has not been established. Our objective was to conduct a systematic review with meta-analys...
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Standardized guidelines for Africanized honeybee venom production needed for development of new apilic antivenom J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2024-01-26 Ricardo Oliveira Orsi, Rodrigo Zaluski, Luciana Curtolo de Barros, Benedito Barraviera, Daniel Carvalho Pimenta, Rui Seabra Ferreira Junior
Africanized bees have spread across the Americas since 1956 and consequently resulted in human and animal deaths attributed to massive attacks related to exposure from Argentina to the USA. In Braz...
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Effects associated with exposure to the emerging contaminant octyl-methoxycinnamate (a UV-B filter) in the aquatic environment: a review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2024-01-26 Margarida Lorigo, Carla Quintaneiro, Luiza Breitenfeld, Elisa Cairrao
Given the increasing concern surrounding ultraviolet (UV) radiation-induced skin damage, there has been a rise in demand for UV filters. Currently, UV-filters are considered emerging contaminants. ...
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Bioactive alkaloids from the venom of Dendrobatoidea Cope, 1865: a scoping review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-11-28 Débora Regina dos Santos Arraes, Alex Bruno Lobato Rodrigues, Patrick Ribeiro Sanches, Carlos Eduardo Costa Campos, Sheylla Susan Moreira da Silva de Almeida, Janaina Reis Ferreira Lima, Jucivaldo Dias Lima, Gabriel Araujo da Silva
Bioactive compounds derived from secondary metabolism in animals have refined selectivity and potency for certain biological targets. The superfamily Dendrobatoidea is adapted to the dietary seques...
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Systemic health effects of noise exposure J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-11-28 Li Yang, Daniel E. Gutierrez, O’neil W. Guthrie
Noise, any unwanted sound, is pervasive and impacts large populations worldwide. Investigators suggested that noise exposure not only induces auditory damage but also produces various organ system ...
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Drug induced liver injury – a 2023 update J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-10-19 Rebecca Allison, Asha Guraka, Isaac Thom Shawa, Gyan Tripathi, Wolfgang Moritz, Ali Kermanizadeh
Drug-Induced Liver Injury (DILI) constitutes hepatic damage attributed to drug exposure. DILI may be categorized as hepatocellular, cholestatic or mixed and might also involve immune responses. Whe...
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Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-08-22 Camila dos Reis Oliveira, Joedna Cavalcante Pereira, Andressa Barros Ibiapina, Italo Rossi Roseno Martins, João Marcelo de Castro e Sousa, Paulo Michel Pinheiro Ferreira, Felipe Cavalcanti Carneiro da Silva
Buthionine sulfoximine (BSO) is a synthetic amino acid that blocks the biosynthesis of reduced glutathione (GSH), an endogenous antioxidant cellular component present in tumor cells. GSH levels hav...
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Continent-based systematic review of the short-term health impacts of wildfire emissions J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-07-19 Bela Barros, Marta Oliveira, Simone Morais
ABSTRACT This review systematically gathers and provides an analysis of pollutants levels emitted from wildfire (WF) and their impact on short-term health effects of affected populations. The available literature was searched according to Population, Exposure, Comparator, Outcome, and Study design (PECOS) database defined by the World Health Organization (WHO) and a meta-analysis was conducted whenever
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Effects of green tea polyphenols against metal-induced genotoxic damage: underlying mechanistic pathways J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-06-12 María Del Carmen García-Rodríguez, Lourdes Montserrat Hernández-Cortés, Víctor Manuel Mendoza-Núñez, Francisco Arenas-Huertero
ABSTRACT This review is based upon evidence from the published effects of green tea polyphenols (GTP) on genotoxic damage induced by metals with carcinogenic potential. First, the relationship between GTP and antioxidant defense system is provided. Subsequently, the processes involved in the oxidative stress generated by metals and their relationship to oxidative DNA damage is examined. The review
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Evaluation of the carcinogenicity of carbon tetrachloride J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-06-06 Samuel M. Cohen, Christopher Bevan, Bhaskar Gollapudi, James E. Klaunig
ABSTRACT Carbon tetrachloride (CCl4) has been extensively used and reported to produce toxicity, most notably involving the liver. Carbon tetrachloride metabolism involves CYP450-mediated bioactivation to trichloromethyl and trichloromethyl peroxy radicals, which are capable of macromolecular interaction with cell components including lipids and proteins. Radical interaction with lipids produces lipid
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Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-05-29 Susan S. Schiffman, Elizabeth H. Scholl, Terrence S. Furey, H. Troy Nagle
ABSTRACT The purpose of this study was to determine the toxicological and pharmacokinetic properties of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6-acetate is an intermediate and impurity in the manufacture of sucralose, and recent commercial sucralose samples were found to contain up to 0.67% sucralose-6-acetate. Studies in a rodent model found that
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Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD) J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-05-14 Priya Upadhyay, Ching-Wen Wu, Alexa Pham, Amir A. Zeki, Christopher M. Royer, Urmila P. Kodavanti, Minoru Takeuchi, Hasan Bayram, Kent E. Pinkerton
ABSTRACT Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and its global health burden is increasing. COPD is characterized by emphysema, mucus hypersecretion, and persistent lung inflammation, and clinically by chronic airflow obstruction and symptoms of dyspnea, cough, and fatigue in patients. A cluster of pathologies including chronic bronchitis, emphysema
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Drug development, Brazilian biodiversity and political choices: Where are we heading? J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-03-26 Paulo Michel Pinheiro Ferreira, Daniel Dias Rufino Arcanjo, Ana Paula Peron
ABSTRACT The aim of this review was to (i) acknowledge structural advantages of natural products (NPs) for designing therapeutic drugs; (ii) emphasize how wildlife conservation is socially and economically necessary for scientific and commercial progress in Brazilian regions; and (iii) show how decisions by governmental regulations exert damaging effects on safeguarding of biodiversity. Natural products
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In vitro data for fire pollutants: contribution of studies using human cell models towards firefighters’ occupational J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-03-08 Maria João Bessa, Bruno Sarmento, Marta Oliveira, Francisca Rodrigues
ABSTRACT Firefighters are the principal line of defense against fires, being at elevated risk of exposure to health-relevant pollutants released during fires and burning processes. Although many biomonitoring studies exist, only a limited number of human in vitro investigations in fire risk assessment are currently available. In vitro studies stand out as valuable tools to assess the toxicity mechanisms
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Experimental models of chemically induced Parkinson’s disease in zebrafish at the embryonic larval stage: a systematic review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-03-01 Paola Briñez-Gallego, Dennis Guilherme da Costa Silva, Marcos Freitas Cordeiro, Ana Paula Horn, Mariana Appel Hort
ABSTRACT Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra that results in a decrease in dopamine levels, resulting in motor-type disturbances. Different vertebrate models, such as rodents and fish, have been used to study PD. In recent decades, Danio rerio (zebrafish) has emerged as a potential model for the investigation
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A comprehensive overview of genotoxicity and mutagenicity associated with outdoor air pollution exposure in Brazil J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-02-12 Vera Maria Ferrão Vargas, Flavio Manoel Rodrigues da Silva Júnior, Tatiana da Silva Pereira, Cristiane Silva da Silva, Mariana Vieira Coronas
ABSTRACT This review examined the mutagenicity and genotoxicity associated with exposure to outdoor air pollutants in Brazil. A search was performed on the Web of Science database using a combination of keywords that resulted in 134 articles. After applying exclusion criteria, a total of 75 articles were obtained. The articles were classified into three categories: (1) studies with plants and animals
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Trichoderma after crossing kingdoms: infections in human populations J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-02-06 Uener Ribeiro dos Santos, Jane Lima dos Santos
ABSTRACT Trichoderma is a saprophytic fungus that is used worldwide as a biocontrol and biofertilizer agent. Although considered nonpathogenic until recently, reports of human infections produced by members of the Trichoderma genus are increasing. Numerous sources of infection were proposed based upon patient data and phylogenetic analysis, including air, agriculture, and healthcare facilities, but
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Biomonitoring of firefighting forces: a review on biomarkers of exposure to health-relevant pollutants released from fires J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-02-06 Bela Barros, Marta Oliveira, Simone Morais
ABSTRACT Occupational exposure as a firefighter has recently been classified as a carcinogen to humans by International Agency for Research on Cancer (IARC). Biomonitoring has been increasingly used to characterize exposure of firefighting forces to contaminants. However, available data are dispersed and information on the most relevant and promising biomarkers in this context of firefighting is missing
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Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-01-24 Maria João Bessa, Fátima Brandão, Fernanda Rosário, Luciana Moreira, Ana Teresa Reis, Vanessa Valdiglesias, Blanca Laffon, Sónia Fraga, João Paulo Teixeira
ABSTRACT Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relationship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure
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Polycyclic aromatic hydrocarbons (PAHs): Updated aspects of their determination, kinetics in the human body, and toxicity J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2023-01-08 Fernando Barbosa Jr, Bruno A. Rocha, Marília C. O. Souza, Mariana Z. Bocato, Lara F. Azevedo, Joseph A. Adeyemi, Anthony Santana, Andres D. Campiglia
ABSTRACT Polycyclic aromatic hydrocarbons (PAHs) are legacy pollutants of considerable public health concern. Polycyclic aromatic hydrocarbons arise from natural and anthropogenic sources and are ubiquitously present in the environment. Several PAHs are highly toxic to humans with associated carcinogenic and mutagenic properties. Further, more severe harmful effects on human- and environmental health
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Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-12-06 Sreejesh Sreedharan, Georgios Zouganelis, Samantha J Drake, Gyanendra Tripathi, Ali Kermanizadeh
ABSTRACT The integration of nanomaterials (NMs) into an ever-expanding number of daily used products has proven to be highly desirable in numerous industries and applications. Unfortunately, the same “nano” specific physicochemical properties, which make these materials attractive, may also contribute to hazards for individuals exposed to these materials. In 2021, it was estimated that 7 out of 10
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Ecotoxicological perspectives of microplastic pollution in amphibians J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-11-09 Mario A. Burgos-Aceves, Caterina Faggio, Miguel Betancourt-Lozano, Donají J. González-Mille, César A. Ilizaliturri-Hernández
ABSTRACT Microplastics (MPs) are contaminants widely distributed in the environment and biota. Previously, most studies focused on identifying and characterizing microplastics in the marine environment, while their impact on freshwater ecosystems remains to be determined. This review summarizes recent findings regarding MPs physiological, immunological, and genetic effects on amphibians based upon
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A comparison of fine particulate matter (PM2.5) in vivo exposure studies incorporating chemical analysis J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-11-09 Allie Sidwell, Samuel Cole Smith, Courtney Roper
ABSTRACT The complex, variable mixtures present in fine particulate matter (PM2.5) have been well established, and associations between chemical constituents and human health are expanding. In the past decade, there has been an increase in PM2.5 toxicology studies that include chemical analysis of samples. This investigation is a crucial component for identifying the causal constituents for observed
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Idiopathic Pulmonary Fibrosis: What do we Know about the Role of Occupational and Environmental Determinants? A Systematic Literature Review and Meta-Analysis J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-10-17 A. Pauchet, A. Chaussavoine, JC Pairon, C. Gabillon, A. Didier, I. Baldi, Y. Esquirol
ABSTRACT The objectives of this systematic review of original articles published up until August 2021 and meta-analyses were to identify the links between occupational and non-occupational environmental exposures, types of occupations and idiopathic pulmonary fibrosis (IPF). Sixteen selected case-control studies were qualified as good level with Newcastle-Ottawa quality assessment scale. Sensitivity
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Current trends in read-across applications for chemical risk assessments and chemical registrations in the Republic of Korea J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-10-17 Sang Hee Lee, Jongwoon Kim, Jinyong Kim, Jaehyun Park, Sanghee Park, Kyu-Bong Kim, Byung-Mu Lee, Seok Kwon
ABSTRACT Read-across, an alternative approach for hazard assessment, has been widely adopted when in vivo data are unavailable for chemicals of interest. Read-across is enabled via in silico tools such as quantitative structure activity relationship (QSAR) modeling. In this study, the current status of structure activity relationship (SAR)-based read-across applications in the Republic of Korea (ROK)
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Pulmonary effects of e-liquid flavors: a systematic review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-09-25 Felix Effah, Benjamin Taiwo, Deborah Baines, Alexis Bailey, Tim Marczylo
ABSTRACT Electronic cigarettes (ECs) are purported to be tobacco harm-reduction products whose degree of harm has been highly debated. EC use is considered less hazardous than smoking but is not expected to be harmless. Following the banning of e-liquid flavors in countries such as the US, Finland, Ukraine, and Hungary, there are growing concerns regarding the safety profile of e-liquid flavors used
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Principles of risk decision-making J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-08-18 Daniel Krewski, Patrick Saunders-Hastings, Patricia Larkin, Margit Westphal, Michael G. Tyshenko, William Leiss, Maurice Dusseault, Michael Jerrett, Doug Coyle
ABSTRACT Risk management decisions in public health require consideration of a number of complex, often conflicting factors. The aim of this review was to propose a set of 10 fundamental principles to guide risk decision-making. Although each of these principles is sound in its own right, the guidance provided by different principles might lead the decision-maker in different directions. For example
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A comprehensive summary of disease variants implicated in metal allergy J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-08-16 Ka Roach, Jr Roberts
ABSTRACT Allergic disease represents one of the most prominent global public health crises of the 21st century. Although many different substances are known to produce hypersensitivity responses, metals constitute one of the major classes of allergens responsible for a disproportionately large segment of the total burden of disease associated with allergy. Some of the most prevalent forms of metal
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Identification of effective control technologies for additive manufacturing J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-06-26 Johan du Plessis, Sonette du Preez, Aleksandr B. Stefaniak
ABSTRACT Additive manufacturing (AM) refers to several types of processes that join materials to build objects, often layer-by-layer, from a computer-aided design file. Many AM processes release potentially hazardous particles and gases during printing and associated tasks. There is limited understanding of the efficacy of controls including elimination, substitution, administrative, and personal protective
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Glyphosate and neurological outcomes: A systematic literature review of animal studies J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-06-08 Virginia C Moser, Keith Morris-Schaffer, Jason R Richardson, Abby A Li
ABSTRACT Studies of nervous system effects of glyphosate, a widely used herbicide, have not been critically examined. The aim of this paper was to systematically review glyphosate-induced neurotoxicity literature to determine its usefulness in regulatory decision-making. The review was restricted to mammalian studies of behavior, neuropathology, and neuropharmacology; in vitro and other biochemical
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Methyl-tert-butyl ether (MTBE): integration of rat and mouse carcinogenicity data with mode of action and human and rodent bioassay dosimetry and toxicokinetics indicates MTBE is not a plausible human carcinogen J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-03-15 James S. Bus, B. Bhaskar Gollapudi, Gordon C. Hard
ABSTRACT Methyl-tert-butyl ether (MTBE) is a fuel oxygenate used in non-United States geographies. Multiple health reviews conclude that MTBE is not a human-relevant carcinogen, and this review provides updated mode of action (MOA), exposure, dosimetry and risk perspectives supporting those conclusions. MTBE is non-genotoxic and has large margins of exposure between blood concentrations at the overall
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The wash-in effect and its significance for mass casualty decontamination J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-02-27 Thomas James, Lydia Izon-Cooper, Samuel Collins, Haydn Cole, Tim Marczylo
ABSTRACT Decontamination of skin by washing may increase dermal absorption, a phenomenon known as the wash-in effect. The wash-in effect is frequently discussed in studies investigating casualty decontamination where potentially life-saving interventions may enhance the dermal penetration of toxic chemicals, leading to an increase in incidence of morbidity and rates of mortality. However, the wash-in
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Genetic variants affecting chemical mediated skin immunotoxicity J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-01-03 Isisdoris Rodrigues de Souza, Patrícia Savio de Araujo-Souza, Daniela Morais Leme
ABSTRACT The skin is an immune-competent organ and this function may be impaired by exposure to chemicals, which may ultimately result in immune-mediated dermal disorders. Interindividual variability to chemical-induced skin immune reactions is associated with intrinsic individual characteristics and their genomes. In the last 30–40 years, several genes influencing susceptibility to skin immune reactions
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Regional variation in percutaneous absorption in in vitro human models: a systematic review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2022-01-30 Aileen M. Feschuk, Nadia Kashetsky, Chavy Chiang, Anuk Burli, Halie Burdick, Howard I. Maibach
ABSTRACT Percutaneous absorption is of importance given its role in topical medicaments, transdermal drug systems, and dermatotoxicology. Many factors influence percutaneous penetration, including anatomical region, although little is currently known regarding this parameter. Hence, the aim of this study was to summarize existing data on regional variation in percutaneous penetration in in vitro human
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The transplacental transfer efficiency of per- and polyfluoroalkyl substances (PFAS): a first meta-analysis J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-12-20 Mareike Appel, Martin Forsthuber, Romualdo Ramos, Raimund Widhalm, Sebastian Granitzer, Maria Uhl, Markus Hengstschläger, Tanja Stamm, Claudia Gundacker
ABSTRACT Per- and polyfluorinated substances (PFAS), ubiquitously present in the environment and biota, are transferred to the fetus via the placenta. PFAS can be distinguished, among other things, by their different carbon chain lengths and functional groups. The aim of this study was to provide comprehensive evidence on PFAS transfer rates across the human placental barrier by means of a meta-analysis
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Interconnected soil iron and arsenic speciation effects on arsenic bioaccessibility and bioavailability: a scoping review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-10-27 Tyler D. Sowers, Clay M. Nelson, Matthew D. Blackmon, Marissa L. Jerden, Alicia M. Kirby, Gary L. Diamond, Karen D. Bradham
ABSTRACT Extensive research has examined arsenic (As) bioavailability in contaminated soils and is routinely assessed using in vitro bioaccessibility (IVBA) assays. Analysis of differences in bioaccessibility measurements across IVBA assays and phases is expected to provide valuable insights into geochemical mechanisms controlling soil As bioaccessibility and bioavailability. Soil iron (Fe) content
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A review of the toxicology of oil in vertebrates: what we have learned following the Deepwater Horizon oil spill J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-09-19 Ryan Takeshita, Steven J. Bursian, Kathleen M. Colegrove, Tracy K. Collier, Kristina Deak, Karen M. Dean, Sylvain De Guise, Lisa M. DiPinto, Cornelis J. Elferink, Andrew J. Esbaugh, Robert J. Griffitt, Martin Grosell, Kendal E. Harr, John P. Incardona, Richard K. Kwok, Joshua Lipton, Carys L. Mitchelmore, Jeffrey M. Morris, Edward S. Peters, Aaron P. Roberts, Teresa K. Rowles, Jennifer A. Rusiecki
ABSTRACT In the wake of the Deepwater Horizon (DWH) oil spill, a number of government agencies, academic institutions, consultants, and nonprofit organizations conducted lab- and field-based research to understand the toxic effects of the oil. Lab testing was performed with a variety of fish, birds, turtles, and vertebrate cell lines (as well as invertebrates); field biologists conducted observations
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Efficacy of soap and water based skin decontamination using in vivo animal models: a systematic review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-07-18
ABSTRACT Water-only or soap and water solutions are considered a gold standard for skin decontamination. However, there is lack of conclusive data regarding their efficacy. The aim of this study was to summarize in vivo animal model data on skin decontamination using water-only, and/or soap and water. Covidence, Embase, MEDLINE, PubMed, Web of Science, and Google Scholar were searched to identify relevant
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Efficacy of water-based skin decontamination of occupational chemicals using in vitro human skin models: a systematic review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-07-26
ABSTRACT Percutaneous absorption of chemicals is a potential route of topical and systemic toxicity. Skin decontamination interrupts this process by removing contaminants from the skin surface. Decontamination using water-only or soap and water solutions is the current gold standard despite limited efficacy data. A summary of studies evaluating their efficacy in decontaminating occupational contaminants
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Assessment of risks to listed species from the use of atrazine in the USA: a perspective J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-07-05 Philip N Smith, Kevin L Armbrust, Richard A. Brain, Wenlin Chen, Nika Galic, Lula Ghebremichael, Jeffrey M Giddings, Mark L Hanson, Jonathan Maul, Glen Van Der Kraak, Keith R Solomon
ABSTRACT Atrazine is a triazine herbicide used predominantly on corn, sorghum, and sugarcane in the US. Its use potentially overlaps with the ranges of listed (threatened and endangered) species. In response to registration review in the context of the Endangered Species Act, we evaluated potential direct and indirect impacts of atrazine on listed species and designated critical habitats. Atrazine
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Additive Manufacturing for Occupational Hygiene: A Comprehensive Review of Processes, Emissions, & Exposures J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-06-17 A.B. Stefaniak, S Du Preez, JL Du Plessis
ABSTRACT This comprehensive review introduces occupational (industrial) hygienists and toxicologists to the seven basic additive manufacturing (AM) process categories. Forty-six articles were identified that reported real-world measurements for all AM processes, except sheet lamination. Particles released from powder bed fusion (PBF), material jetting (MJ), material extrusion (ME), and directed energy
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Improving the predictive value of bioaccessibility assays and their use to provide mechanistic insights into bioavailability for toxic metals/metalloids – A research prospectus J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-06-06 Jennifer L. Griggs, David J. Thomas, Rebecca Fry, Karen D. Bradham
ABSTRACT Widespread contamination of soil, dust, and food with toxic metal(loid)s pose a significant public health concern. Only a portion of orally ingested metal(loid) contaminants are bioavailable, which is defined as the fraction of ingested metal(loid)s absorbed across the gastrointestinal barrier and into systemic circulation. Bioaccessibility tools are a class of in vitro assays used as a surrogate
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Current opinion on risk assessment of cosmetics J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-04-08 Kyu-Bong Kim, Seung Jun Kwack, Joo Young Lee, Sam Kacew, Byung-Mu Lee
ABSTRACT Risk assessment of cosmetic ingredients is a useful scientific method to characterize potential adverse effects resulting from using cosmetics. The process of risk assessment consists of four steps: hazard identification, dose-response assessment, exposure assessment, and risk characterization. Hazard identification of chemicals refers to the initial stage of risk assessment and generally
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Vibrotactile sensitivity testing for occupational and disease-induce peripheral neuropathies J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-03-14 Kristine Krajnak
ABSTRACT The International Standard Organization (ISO) standard 13091–1 describes methods and procedures for performing the vibrotactile perception threshold (VPT) testing to diagnose changes in tactile sensory function associated with occupational exposures. However, the VPT test also has been used in the diagnosis of peripheral neuropathies associated with a number of disorders. This review examines
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Arsenic exposure from groundwater: environmental contamination, human health effects, and sustainable solutions J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-03-12 Elida Cristina Monteiro De Oliveira, Evelyn Siqueira Caixeta, Vanessa Santana Vieira Santos, Boscolli Barbosa Pereira
ABSTRACT Arsenic (As) occurs naturally in geologic conditions, but groundwater contamination might also be found due to the consequences of mining, agricultural and industrial processes. Human exposure to As after drinking contaminated water is commonly associated with acute toxicity outcomes and chronic effects ranging from skin lesions to cancer. Integrated actions from environmental and health authorities
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Xenobiotic metabolism and transport in Caenorhabditis elegans J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2021-02-22 Jessica H. Hartman, Samuel J. Widmayer, Christina M. Bergemann, Dillon E. King, Katherine S. Morton, Riccardo F. Romersi, Laura E. Jameson, Maxwell C. K. Leung, Erik C. Andersen, Stefan Taubert, Joel N. Meyer
ABSTRACT Caenorhabditis elegans has emerged as a major model in biomedical and environmental toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been published, and this species has now been adopted by investigators in academic toxicology, pharmacology, and drug discovery labs. C. elegans has also attracted the interest of governmental regulatory agencies charged with evaluating
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Ethylene oxide review: characterization of total exposure via endogenous and exogenous pathways and their implications to risk assessment and risk management J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-12-15 CR Kirman, AA Li, PJ Sheehan, JS Bus, RC Lewis, SM Hays
ABSTRACT This review is intended to provide risk assessors and risk managers with a better understanding of issues associated with total exposures of human populations to ethylene oxide from endogenous and exogenous pathways. Biomonitoring of human populations and lab animals exposed to ethylene oxide has relied upon the detection of hemoglobin adducts such as 2-hydroxyethylvaline (HEV), which provides
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Good management practices of venomous snakes in captivity to produce biological venom-based medicines: achieving replicability and contributing to pharmaceutical industry J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-12-14 Lucilene Santos, Cristiano Oliveira, Barbara Marques Vasconcelos, Daniela Vilela, Leonardo Melo, Lívia Ambrósio, Amanda da Silva, Leticia Murback, Jacqueline Kurissio, Joeliton Cavalcante, Claudia Vilalva Cassaro, Luciana Barros, Benedito Barraviera, Rui Seabra Ferreira Junior
ABSTRACT One of the factors responsible for lack of reproducible findings may be attributed to the raw material used. To date, there are no apparent studies examining reproducibility using venoms for the development of new toxin-based drugs with respect to regulatory agencies' policies. For this reason, protocols were implemented to produce animal toxins with quality, traceability, and strict compliance
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Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-12-23 Jae Hyeon Park, Byung Mu Lee, Hyung Sik Kim
ABSTRACT Curcumin, used as a spice and traditional medicine in India, exerts beneficial effects against several diseases, owing to its antioxidant, analgesic, and anti-inflammatory properties. Evidence indicates that curcumin might protect against heavy metal-induced organ toxicity by targeting biological pathways involved in anti-oxidation, anti-inflammation, and anti-tumorigenesis. Curcumin has received
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Atmospheric fine particulate matter and epithelial mesenchymal transition in pulmonary cells: state of the art and critical review of the in vitro studies. J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-09-13 Margaux Cochard,Frédéric Ledoux,Yann Landkocz
ABSTRACT Exposure to fine particulate matter (PM2.5) has been associated with several diseases including asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. Mechanisms such as oxidative stress and inflammation are well-documented and are considered as the starting point of some of the pathological responses. However, a number of studies also focused on epithelial-mesenchymal transition
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Effects of ambient particulate matter on vascular tissue: a review J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-09-24 Kristina Shkirkova, Krista Lamorie-Foote, Michelle Connor, Arati Patel, Giuseppe Barisano, Hans Baertsch, Qinghai Liu, Todd E. Morgan, Constantinos Sioutas, William J. Mack
ABSTRACT Fine and ultra-fine particulate matter (PM) are major constituents of urban air pollution and recognized risk factors for cardiovascular diseases. This review examined the effects of PM exposure on vascular tissue. Specific mechanisms by which PM affects the vasculature include inflammation, oxidative stress, actions on vascular tone and vasomotor responses, as well as atherosclerotic plaque
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Low toxicity and high efficacy in use of novel approaches to control Aedes aegypti. J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-06-09 Vanessa Santana Vieira Santos,Boscolli Barbosa Pereira
Arthropod-borne viruses are a group of etiologic agents accounting for different incapacitating diseases that progress to severe and lethal forms in animal and human targets consequently representing a significant burden on public health and global economies. Although attempts were undertaken to combat Aedes aegypti, the primary urban mosquito vector of several life-threatening diseases, the misuse
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Targeting gap junctional intercellular communication by hepatocarcinogenic compounds. J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-06-22 Kaat Leroy,Alanah Pieters,Andrés Tabernilla,Axelle Cooreman,Raf Van Campenhout,Bruno Cogliati,Mathieu Vinken
Gap junctions in liver, as in other organs, play a critical role in tissue homeostasis. Inherently, these cellular constituents are major targets for systemic toxicity and diseases, including cancer. This review provides an overview of chemicals that compromise liver gap junctions, in particular biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. The
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Per- and polyfluoroalkyl substances and male reproductive health: a systematic review of the epidemiological evidence. J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-08-02 Kajsa Ugelvig Petersen,Josefine Rahbæk Larsen,Laura Deen,Esben Meulengracht Flachs,Katia Keglberg Hærvig,Sidsel Dan Hull,Jens Peter Ellekilde Bonde,Sandra Søgaard Tøttenborg
Exposure to environmental pollutants may produce impairment of male reproductive health. The epidemiological literature evaluating potential consequences of human exposure to per- and polyfluoroalkyl substances (PFAS) has grown in recent years with concerns for both pre- and postnatal influences. The aim of this systematic review was to assess available evidence on associations between PFAS exposures
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Relevance of mouse lung tumors to human risk assessment. J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-05-25 Samuel M Cohen,Yan Zhongyu,James S Bus
Mouse lung is a common site for chemical tumorigenicity, but the relevance to human risk remains debated. Long-term bioassays need to be assessed for appropriateness of the dose, neither exceeding Maximum Tolerated Dose (MTD) nor Kinetically based Maximum Dose (KMD). An example of the KMD issue is 1,3-dichloropropene (1,3-D), which only produced an increased incidence of lung tumors at a dose exceeding
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A critical review of talc and ovarian cancer. J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-05-13 Julie E Goodman,Laura E Kerper,Robyn L Prueitt,Charlotte M Marsh
ABSTRACT The association between perineal talc use and ovarian cancer has been evaluated in several epidemiology studies. Some case-control studies reported weak positive associations, while other case-control and three large prospective cohort investigations found this association to be null. A weight-of-evidence evaluation was conducted of the epidemiology, toxicity, exposure, transport, in vitro
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A critical review of talc and ovarian cancer J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-05-13 Julie E. Goodman, Laura E. Kerper, Robyn L. Prueitt, Charlotte M. Marsh
ABSTRACT The association between perineal talc use and ovarian cancer has been evaluated in several epidemiology studies. Some case-control studies reported weak positive associations, while other case-control and three large prospective cohort investigations found this association to be null. A weight-of-evidence evaluation was conducted of the epidemiology, toxicity, exposure, transport, in vitro
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A review of hepatic nanotoxicology - summation of recent findings and considerations for the next generation of study designs. J. Toxicol. Environ. Health B Crit. Rev. (IF 7.2) Pub Date : 2020-04-23 Ali Kermanizadeh,Leagh G Powell,Vicki Stone
The liver is one of the most important multi-functional organs in the human body. Amongst various crucial functions, it is the main detoxification center and predominantly implicated in the clearance of xenobiotics potentially including particulates that reach this organ. It is now well established that a significant quantity of injected, ingested or inhaled nanomaterials (NMs) translocate from primary