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Ethylene oxide review: characterization of total exposure via endogenous and exogenous pathways and their implications to risk assessment and risk management J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-12-15 CR Kirman; AA Li; PJ Sheehan; JS Bus; RC Lewis; SM Hays
ABSTRACT This review is intended to provide risk assessors and risk managers with a better understanding of issues associated with total exposures of human populations to ethylene oxide from endogenous and exogenous pathways. Biomonitoring of human populations and lab animals exposed to ethylene oxide has relied upon the detection of hemoglobin adducts such as 2-hydroxyethylvaline (HEV), which provides
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Good management practices of venomous snakes in captivity to produce biological venom-based medicines: achieving replicability and contributing to pharmaceutical industry J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-12-14 Lucilene Santos; Cristiano Oliveira; Barbara Marques Vasconcelos; Daniela Vilela; Leonardo Melo; Lívia Ambrósio; Amanda da Silva; Leticia Murback; Jacqueline Kurissio; Joeliton Cavalcante; Claudia Vilalva Cassaro; Luciana Barros; Benedito Barraviera; Rui Seabra Ferreira Junior
ABSTRACT One of the factors responsible for lack of reproducible findings may be attributed to the raw material used. To date, there are no apparent studies examining reproducibility using venoms for the development of new toxin-based drugs with respect to regulatory agencies' policies. For this reason, protocols were implemented to produce animal toxins with quality, traceability, and strict compliance
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Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-12-23 Jae Hyeon Park; Byung Mu Lee; Hyung Sik Kim
ABSTRACT Curcumin, used as a spice and traditional medicine in India, exerts beneficial effects against several diseases, owing to its antioxidant, analgesic, and anti-inflammatory properties. Evidence indicates that curcumin might protect against heavy metal-induced organ toxicity by targeting biological pathways involved in anti-oxidation, anti-inflammation, and anti-tumorigenesis. Curcumin has received
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Atmospheric fine particulate matter and epithelial mesenchymal transition in pulmonary cells: state of the art and critical review of the in vitro studies. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-09-13 Margaux Cochard,Frédéric Ledoux,Yann Landkocz
ABSTRACT Exposure to fine particulate matter (PM2.5) has been associated with several diseases including asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. Mechanisms such as oxidative stress and inflammation are well-documented and are considered as the starting point of some of the pathological responses. However, a number of studies also focused on epithelial-mesenchymal transition
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Effects of ambient particulate matter on vascular tissue: a review J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-09-24 Kristina Shkirkova; Krista Lamorie-Foote; Michelle Connor; Arati Patel; Giuseppe Barisano; Hans Baertsch; Qinghai Liu; Todd E. Morgan; Constantinos Sioutas; William J. Mack
ABSTRACT Fine and ultra-fine particulate matter (PM) are major constituents of urban air pollution and recognized risk factors for cardiovascular diseases. This review examined the effects of PM exposure on vascular tissue. Specific mechanisms by which PM affects the vasculature include inflammation, oxidative stress, actions on vascular tone and vasomotor responses, as well as atherosclerotic plaque
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Low toxicity and high efficacy in use of novel approaches to control Aedes aegypti. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-06-09 Vanessa Santana Vieira Santos,Boscolli Barbosa Pereira
Arthropod-borne viruses are a group of etiologic agents accounting for different incapacitating diseases that progress to severe and lethal forms in animal and human targets consequently representing a significant burden on public health and global economies. Although attempts were undertaken to combat Aedes aegypti, the primary urban mosquito vector of several life-threatening diseases, the misuse
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Targeting gap junctional intercellular communication by hepatocarcinogenic compounds. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-06-22 Kaat Leroy,Alanah Pieters,Andrés Tabernilla,Axelle Cooreman,Raf Van Campenhout,Bruno Cogliati,Mathieu Vinken
Gap junctions in liver, as in other organs, play a critical role in tissue homeostasis. Inherently, these cellular constituents are major targets for systemic toxicity and diseases, including cancer. This review provides an overview of chemicals that compromise liver gap junctions, in particular biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. The
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Per- and polyfluoroalkyl substances and male reproductive health: a systematic review of the epidemiological evidence. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-08-02 Kajsa Ugelvig Petersen,Josefine Rahbæk Larsen,Laura Deen,Esben Meulengracht Flachs,Katia Keglberg Hærvig,Sidsel Dan Hull,Jens Peter Ellekilde Bonde,Sandra Søgaard Tøttenborg
Exposure to environmental pollutants may produce impairment of male reproductive health. The epidemiological literature evaluating potential consequences of human exposure to per- and polyfluoroalkyl substances (PFAS) has grown in recent years with concerns for both pre- and postnatal influences. The aim of this systematic review was to assess available evidence on associations between PFAS exposures
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Relevance of mouse lung tumors to human risk assessment. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-05-25 Samuel M Cohen,Yan Zhongyu,James S Bus
Mouse lung is a common site for chemical tumorigenicity, but the relevance to human risk remains debated. Long-term bioassays need to be assessed for appropriateness of the dose, neither exceeding Maximum Tolerated Dose (MTD) nor Kinetically based Maximum Dose (KMD). An example of the KMD issue is 1,3-dichloropropene (1,3-D), which only produced an increased incidence of lung tumors at a dose exceeding
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A critical review of talc and ovarian cancer. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-05-13 Julie E Goodman,Laura E Kerper,Robyn L Prueitt,Charlotte M Marsh
ABSTRACT The association between perineal talc use and ovarian cancer has been evaluated in several epidemiology studies. Some case-control studies reported weak positive associations, while other case-control and three large prospective cohort investigations found this association to be null. A weight-of-evidence evaluation was conducted of the epidemiology, toxicity, exposure, transport, in vitro
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A critical review of talc and ovarian cancer J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-05-13 Julie E. Goodman; Laura E. Kerper; Robyn L. Prueitt; Charlotte M. Marsh
ABSTRACT The association between perineal talc use and ovarian cancer has been evaluated in several epidemiology studies. Some case-control studies reported weak positive associations, while other case-control and three large prospective cohort investigations found this association to be null. A weight-of-evidence evaluation was conducted of the epidemiology, toxicity, exposure, transport, in vitro
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A review of hepatic nanotoxicology - summation of recent findings and considerations for the next generation of study designs. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-04-23 Ali Kermanizadeh,Leagh G Powell,Vicki Stone
The liver is one of the most important multi-functional organs in the human body. Amongst various crucial functions, it is the main detoxification center and predominantly implicated in the clearance of xenobiotics potentially including particulates that reach this organ. It is now well established that a significant quantity of injected, ingested or inhaled nanomaterials (NMs) translocate from primary
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Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-04-12 Boscolli Barbosa Pereira
As a result of the 2019 coronavirus disease pandemic (COVID-19), there has been an urgent worldwide demand for treatments. Due to factors such as history of prescription for other infectious diseases, availability, and relatively low cost, the use of chloroquine (CQ) and hydroxychloroquine (HCQ) has been tested in vivo and in vitro for the ability to inhibit the causative virus, severe acute respiratory
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Endogenous doesn't always mean innocuous: a scoping review of iron toxicity by inhalation. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-02-27 Jody Morgan,Robin Bell,Alison L Jones
Ambient air pollution is a leading risk factor for the global burden of disease. One possible pathway of particulate matter (PM)-induced toxicity is through iron (Fe), the most abundant metal in the atmosphere. The aim of the review was to consider the complexity of Fe-mediated toxicity following inhalation exposure focusing on the chemical and surface reactivity of Fe as a transition metal and possible
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A male germ cell assay and supporting somatic cells: its application for the detection of phase specificity of genotoxins in vitro. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-02-11 Khaled Habas,Martin H Brinkworth,Diana Anderson
Male germ stem cells are responsible for transmission of genetic information to the next generation. Some chemicals exert a negative impact on male germ cells, either directly, or indirectly affecting them through their action on somatic cells. Ultimately, these effects might inhibit fertility, and may exhibit negative consequences on future offspring. Genotoxic anticancer agents may interact with
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The complex puzzle of dietary silver nanoparticles, mucus and microbiota in the gut. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2020-01-10 Yuqiang Bi,Andrew K Marcus,Hervé Robert,Rosa Krajmalnik-Brown,Bruce E Rittmann,Paul Westerhoff,Marie-Hélène Ropers,Muriel Mercier-Bonin
Hundreds of consumer and commercial products containing silver nanoparticles (AgNPs) are currently used in food, personal-care products, pharmaceutical, and many other applications. Human exposure to AgNPs includes oral intake, inhalation, and dermal contact. The aim of this review was to focus on oral intake, intentional and incidental of AgNPs where well-known antimicrobial characteristics that might
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Potential adverse health effects of ingested micro- and nanoplastics on humans. Lessons learned from in vivo and in vitro mammalian models. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2019-12-10 Laura Rubio,Ricard Marcos,Alba Hernández
In recent years, increasing global attention has focused on "microplastics" (MPs) and "nanoplastics" (NPs) resulting in many studies on the effects of these compounds on ecological and environmental aspects. These tiny particles (<5000 µm), predominantly derived from the degradation of plastics, pollute the marine and terrestrial ecosystems with the ability to enter into the food chain. In this manner
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Genetic toxicity assessment using liver cell models: past, present, and future. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2019-11-20 Xiaoqing Guo,Ji-Eun Seo,Xilin Li,Nan Mei
Genotoxic compounds may be detoxified to non-genotoxic metabolites while many pro-carcinogens require metabolic activation to exert their genotoxicity in vivo. Standard genotoxicity assays were developed and utilized for risk assessment for over 40 years. Most of these assays are conducted in metabolically incompetent rodent or human cell lines. Deficient in normal metabolism and relying on exogenous
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Properties, toxicity and current applications of the biolarvicide spinosad. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2019-11-11 Vanessa Santana Vieira Santos,Boscolli Barbosa Pereira
Characterized as a highly valuable bioactive natural product, spinosad is a pesticide with a complex chemical structure, composed of spinosyn A and D, molecules synthesized by the actinomycete Saccharopolyspora spinosa. The larvicidal activity of spinosad was postulated to be a promising approach to combat crop pests and control species responsible to transmit mosquito-borne illness, including Aedes
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Hearing loss, lead (Pb) exposure, and noise: a sound approach to ototoxicity exploration. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2019-01-22 Krystin Carlson,Richard L Neitzel
To determine the state of the research on ototoxic properties of Pb, evaluate possible synergistic effects with concurrent noise exposure, and identify opportunities to improve future research, we performed a review of the peer-reviewed literature to identify studies examining auditory damage due to Pb over the past 50 years. Thirty-eight studies (14 animal and 24 human) were reviewed. Of these, 24
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Toxicity and applications of surfactin for health and environmental biotechnology. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2019-01-08 Vanessa Santana Vieira Santos,Edgar Silveira,Boscolli Barbosa Pereira
Characterized as one of the most potent biosurfactants, surfactin is a cyclic lipopeptide synthesized by several strains of Bacillus genus. The aim of this review was to present the physicochemical and structural properties of surfactin and to demonstrate advances and applications of this biosurfactant for health and environmental biotechnology. Further, this review also focused on toxicological effects
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Health effects associated with occupational exposure to hand-arm or whole body vibration. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-12-26 Kristine Krajnak
Workers in a number of different occupational sectors are exposed to workplace vibration on a daily basis. This exposure may arise through the use of powered-hand tools or hand-transmitted vibration (HTV). Workers might also be exposed to whole body vibration (WBV) by driving delivery vehicles, earth moving equipment, or through use of tools that generate vibration at low dominant frequencies and high
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Environmental contaminants and preeclampsia: a systematic literature review. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-12-24 Emma M Rosen,Mg Isabel Muñoz,Thomas McElrath,David E Cantonwine,Kelly K Ferguson
Preeclampsia is a medical condition specific to pregnancy characterized by high blood pressure and protein in the woman's urine, indicating kidney damage. It is one of the most serious reproductive conditions, posing substantial risks to the baby and potentially fatal for the mother. The causes of preeclampsia are largely unknown and environmental contaminants merit further investigation. The aim of
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Importance of bacterial biodegradation and detoxification processes of microcystins for environmental health. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-10-31 Isaac Yaw Massey,Xian Zhang,Fei Yang
Microcystins (MC) the most frequently reported cyanobacterial harmful algal bloom toxins primarily found in some species of freshwater genera pose a serious threat to human and animal health. To reduce health risks associated with MC exposure it is important to remove these toxins found in drinking and recreational waterbodies. Since the physical and chemical water treatment methods are inefficient
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Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-10-24 David C Dorman,Weihsueh Chiu,Barbara F Hales,Russ Hauser,Kamin J Johnson,Ellen Mantus,Susan Martel,Karen A Robinson,Andrew A Rooney,Ruthann Rudel,Sheela Sathyanarayana,Susan L Schantz,Katrina M Waters
A recent systematic review (SR) and meta-analysis of human studies found an association between prenatal serum polybrominated diphenyl ethers (PBDE) concentrations and a decrease in the IQ of children. A SR of experimental developmental animal PBDE-mediated neurotoxicity studies was performed in the present study. Outcomes assessed included measures related to learning, memory, and attention, which
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Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-09-11 David C Dorman,Weihsueh Chiu,Barbara F Hales,Russ Hauser,Kamin J Johnson,Ellen Mantus,Susan Martel,Karen A Robinson,Andrew A Rooney,Ruthann Rudel,Sheela Sathyanarayana,Susan L Schantz,Katrina M Waters
Male reproductive alterations found in animals and humans following in utero phthalate exposure include decreased anogenital distance (AGD) and other reproductive-tract malformations. The aim of this investigation was to conduct systematic reviews of human and animal evidence of the effect of in utero exposure to diethylhexyl phthalate (DEHP) on anogenital distance (AGD) in males. PubMed, Embase, and
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Attention Restoration Theory II: a systematic review to clarify attention processes affected by exposure to natural environments. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-08-22 Matt P Stevenson,Theresa Schilhab,Peter Bentsen
Attention Restoration Theory (ART) predicts exposure to natural environments may lead to improved cognitive performance through restoration of a limited cognitive resource, directed attention. A recent review by Ohly and colleagues (2016) uncovered substantial ambiguity surrounding details of directed attention and how cognitive restoration was tested. Therefore, an updated systematic review was conducted
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Human biomarker interpretation: the importance of intra-class correlation coefficients (ICC) and their calculations based on mixed models, ANOVA, and variance estimates. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-08-02 Joachim D Pleil,M Ariel Geer Wallace,Matthew A Stiegel,William E Funk
Human biomonitoring is the foundation of environmental toxicology, community public health evaluation, preclinical health effects assessments, pharmacological drug development and testing, and medical diagnostics. Within this framework, the intra-class correlation coefficient (ICC) serves as an important tool for gaining insight into human variability and responses and for developing risk-based assessments
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The obesogen tributyltin induces features of polycystic ovary syndrome (PCOS): a review. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-07-18 Eduardo Merlo,Ian V Silva,Rodolfo C Cardoso,Jones B Graceli
Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome characterized by abnormal reproductive cycles, irregular ovulation, and hyperandrogenism. This complex disorder has its origins both within and outside the hypothalamic-pituitary-ovarian axis. Cardio-metabolic factors, such as obesity and insulin resistance, contribute to the manifestation of the PCOS phenotype. Polycystic ovary syndrome
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Application of prioritization approaches to optimize environmental monitoring and testing of pharmaceuticals. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-05-02 Emily E Burns,Laura J Carter,Jason Snape,Jane Thomas-Oates,Alistair B A Boxall
Pharmaceuticals are ubiquitous in the natural environment with concentrations expected to rise as human population increases. Environmental risk assessments are available for a small portion of pharmaceuticals in use, raising concerns over the potential risks posed by other drugs that have little or no data. With >1900 active pharmaceutical ingredients in use, it would be a major task to test all of
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Extracellular vesicles released in response to respiratory exposures: implications for chronic disease. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-05-02 Birke J Benedikter,Emiel F M Wouters,Paul H M Savelkoul,Gernot G U Rohde,Frank R M Stassen
Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses. Respiratory exposures such as cigarette smoke and air pollution exert cellular stresses and are associated with an increased risk of several chronic diseases. The aim of this review was to examine the evidence that modifications in EV contribute to
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In vivo and in vitro methods for evaluating soil arsenic bioavailability: relevant to human health risk assessment. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-03-20 Karen D Bradham,Gary L Diamond,Michele Burgess,Albert Juhasz,Julie M Klotzbach,Mark Maddaloni,Clay Nelson,Kirk Scheckel,Sophia M Serda,Marc Stifelman,David J Thomas
Arsenic (As) is the most frequently occurring contaminant on the priority list of hazardous substances, which lists substances of greatest public health concern to people living at or near U.S. National Priorities List site. Accurate assessment of human health risks from exposure to As-contaminated soils depends on estimating its bioavailability, defined as the fraction of ingested As absorbed across
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Arsenic, cadmium, and mercury-induced hypertension: mechanisms and epidemiological findings. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-02-16 Airton da Cunha Martins,Maria Fernanda Hornos Carneiro,Denise Grotto,Joseph A Adeyemi,Fernando Barbosa
Arsenic (As), cadmium (Cd), and mercury (Hg) are toxic elements widely distributed in the environment. Exposure to these elements was attributed to produce several acute and chronic illnesses including hypertension. The aim of this review is to provide a summary of the most frequently proposed mechanisms underlying hypertension associated with As, Cd, and Hg exposure including: oxidative stress, impaired
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Risk management of free radicals involved in air travel syndromes by antioxidants. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-01-18 Jeum-Nam Kim,Byung-Mu Lee
Frequent air travelers and airplane pilots may develop various types of illnesses. The environmental risk factors associated with air travel syndromes (ATS) or air travel-related adverse health outcomes raised concerns and need to be assessed in the context of risk management and public health. Accordingly, the aim of the present review was to determine ATS, risk factors, and mechanisms underlying
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Response to Tennekes (2018) "The Resilience of the Beehive" Journal of Toxicology and Environmental Health B 20: 316-386. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-01-10 Keith R Solomon,Gladys L Stephenson
This paper is a response to a letter from Dr. H Tennekes ("The Resilience of the Beehive" Journal of Toxicology and Environmental Health B 20: 316-386). Here we emphasize that our quantitative weight of evidence analyses were focused on the level of the honeybee colony. These colony-level responses include redundancy and resiliency as well as a number of possible sublethal effects of pesticides on
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Letter to the editor "The resilience of the beehive". J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2018-01-09 Henk A Tennekes
A recent quantitative weight of evidence (QWoE) assessment of higher tier studies on the toxicity and risks of neonicotinoids in honeybees by Solomon and Stephenson reported a colony-level no-observed-adverse effect concentration (NOAEC) of 25 µg/kg (ppb) for imidacloprid and clothianidin. The toxicity of these insecticides to honeybees is however known to be reinforced with chronic exposure, and extrapolation
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From Infections to Anthropogenic Inflicted Pathologies: Involvement of Immune Balance. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-12-19 Florence Lee,David A Lawrence
A temporal trend can be seen in recent human history where the dominant causes of death have shifted from infectious to chronic diseases in industrialized societies. Human influences in the current "Anthropocene" epoch are exponentially impacting the environment and consequentially health. Changing ecological niches are suggested to have created health transitions expressed as modifications of immune
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Risk assessment of benzalkonium chloride in cosmetic products. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-12-07 Seul Min Choi,Tae Hyun Roh,Duck Soo Lim,Sam Kacew,Hyung Sik Kim,Byung-Mu Lee
A risk assessment of benzalkonium chloride (BAC) was conducted based upon its toxicological profile and exposure evaluation. Since 1935, BAC has been used in a wide variety of products such as disinfectants, preservatives, and sanitizers. It is well-established that BAC is not genotoxic nor does it display tumorigenic potential, but safety concerns have been raised in local usage such as for ocular
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Triclosan exposure, transformation, and human health effects. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-29 Lisa M Weatherly,Julie A Gosse
Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the US population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the US Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste
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Author's response to: "Letter to the Editor" regarding content of "Mesothelioma from asbestos exposures: Epidemiologic patterns and impact in the United States" by R. A. Lemen, Journal of Toxicology and Environmental Health, Part B 2016; 19: 250-265. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-29
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Quantitative weight of evidence assessment of higher-tier studies on the toxicity and risks of neonicotinoid insecticides in honeybees 1: Methods. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-22 Keith R Solomon,Gladys L Stephenson
A quantitative weight of evidence (QWoE) methodology was developed and used to assess many higher-tier studies on the effects of three neonicotinoid insecticides: clothianidin (CTD), imidacloprid (IMI), and thiamethoxam (TMX) on honeybees. A general problem formulation, a conceptual model for exposures of honeybees, and an analysis plan were developed. A QWoE methodology was used to characterize the
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Critical and systematic evaluation of data for estimating human exposures to 2,4-dichlorophenoxyacetic acid (2,4-D) - quality and generalizability. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-22 Judy S LaKind,Carol J Burns,Daniel Q Naiman,Cian O'Mahony,Giulia Vilone,Annette J Burns,Joshua S Naiman
The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been commercially available since the 1940's. Despite decades of data on 2,4-D in food, air, soil, and water, as well as in humans, the quality the quality of these data has not been comprehensively evaluated. Using selected elements of the Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument (temporal variability
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Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoids in honeybees. 4. Thiamethoxam. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-22 Gladys L Stephenson,Keith R Solomon
A quantitative weight of evidence (QWoE) methodology was used to assess several higher-tier studies on the effects of thiamethoxam (TMX) on honeybees. Assessment endpoints were population size and viability of commercially managed honeybee colonies and quantity of hive products. A higher-tier field toxicology study indicated a no-observed-adverse effect concentration (NOAEC) of 29.5 µg TMX/kg syrup
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Quantitative weight of evidence assessment of risk to honeybee colonies from use of imidacloprid, clothianidin, and thiamethoxam as seed treatments: a postscript. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-22 Keith R Solomon,Gladys L Stephenson
This paper is a postscript to the four companion papers in this issue of the Journal (Solomon and Stephenson 2017a , 2017b ; Stephenson and Solomon 2017a , 2017b ). The first paper in the series described the conceptual model and the methods of the QWoE process. The other three papers described the application of the QWoE process to studies on imidacloprid (IMI), clothianidin (CTD), and thiamethoxam
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Quantitative weight of evidence assessment of higher tier studies on the toxicity and risks of neonicotinoids in honeybees. 3. Clothianidin. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-17 Keith R Solomon,Gladys L Stephenson
A quantitative weight of evidence (QWoE) methodology was used to assess higher tier studies on the effects of clothianidin (CTD) on honeybees. Assessment endpoints were population size and viability of commercially managed bees and quantity of hive products. A colony-level no-observed-adverse effect concentration (NOAEC) of 25 µg CTD/kg syrup, equivalent to an oral no-observed-adverse effect-dose (NOAED)
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Quantitative weight of evidence assessment of higher-tier studies on the toxicity and risks of neonicotinoids in honeybees. 2. Imidacloprid. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-16 Gladys L Stephenson,Keith R Solomon
A quantitative weight of evidence (QWoE) methodology was used to assess higher-tier studies on the effects of imidacloprid (IMI) on honeybees. Assessment endpoints were population size and viability of commercially managed bees and quantity of hive products. A colony-level no-observed-adverse effect concentration (NOAEC) of 25 µg IMI/kg syrup, equivalent to an oral no-observed-adverse-effect-dose of
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Comment on "Mesothelioma from asbestos exposures: Epidemiologic patterns and impact in the United States" by R A Lemen, Journal of Toxicology and Environmental Health, Part B 2016;19:250-265. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-11-14 Corrado Magnani,Dario Mirabelli,Benedetto Terracini
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Review of reviews on exposures to synthetic organic chemicals and children's neurodevelopment: Methodological and interpretation challenges. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-09-28 Judy S LaKind,Laura G Anthony,Michael Goodman
Environmental epidemiology data are becoming increasingly important in public health decision making, which commonly incorporates a systematic review of multiple studies. This review addresses two fundamental questions: What is the quality of available reviews on associations between exposure to synthetic organic chemicals and neurodevelopmental outcomes? What is the value (e.g., quality and consistency)
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Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-09-13 Cheryl S Rosenfeld,Nancy D Denslow,Edward F Orlando,Juan Manuel Gutierrez-Villagomez,Vance L Trudeau
In vertebrates, sexual differentiation of the reproductive system and brain is tightly orchestrated by organizational and activational effects of endogenous hormones. In mammals and birds, the organizational period is typified by a surge of sex hormones during differentiation of specific neural circuits; whereas activational effects are dependent upon later increases in these same hormones at sexual
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Letter to the editor: Attention restoration in natural environments: Mixed mythical metaphors for meta-analysis. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-08-29 Terry Hartig,Helena Jahncke
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Impact of mycotoxins on the intestine: are mucus and microbiota new targets? J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-06-22 Hervé Robert,Delphine Payros,Philippe Pinton,Vassilia Théodorou,Muriel Mercier-Bonin,Isabelle P Oswald
There is an increasing awareness of the deleterious effects attributed to mycotoxins during their fate within the gut, particularly for deoxynivalenol (DON), zearalenone (ZEN), ochratoxin A (OTA), fumonisin B1 (FB1), aflatoxin B1 (AFB1), and patulin (PAT). Evidence indicates that disruption of the epithelial barrier is well established. However, intestinal barrier function on its luminal side involves
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Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-06-21 Melisa Bunderson-Schelvan,Andrij Holian,Raymond F Hamilton
Engineered nanomaterials (ENMs), or small anthropogenic particles approximately < 100 nm in size and of various shapes and compositions, are increasingly incorporated into commercial products and used for industrial and medical purposes. There is an exposure risk to both the population at large and individuals in the workplace with inhalation exposures to ENMs being a primary concern. Further, there
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A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-06-10 N Chernoff,D J Hill,D L Diggs,B D Faison,B M Francis,J R Lang,M M Larue,T-T Le,K A Loftin,J N Lugo,J E Schmid,W M Winnik
The compound BMAA (β-N-methylamino-L-alanine) has been postulated to play a significant role in four serious neurological human diseases: Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex (ALS/PDC) found on Guam, and ALS, Parkinsonism, and dementia that occur globally. ALS/PDC with symptoms of all three diseases first came to the attention of the scientific community during and after World
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Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-05-17 Kyu-Bong Kim,Young Woo Kim,Seong Kwang Lim,Tae Hyun Roh,Du Yeon Bang,Seul Min Choi,Duck Soo Lim,Yeon Joo Kim,Seol-Hwa Baek,Min-Kook Kim,Hyo-Seon Seo,Min-Hwa Kim,Hyung Sik Kim,Joo Young Lee,Sam Kacew,Byung-Mu Lee
Zinc oxide (ZnO), an inorganic compound that appears as a white powder, is used frequently as an ingredient in sunscreens. The aim of this review was to examine the toxicology and risk assessment of ZnO based upon available published data. Recent studies on acute, sub-acute, and chronic toxicities of ZnO indicated that this compound is virtually non-toxic in animal models. However, it was reported
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Biomarkers of mercury toxicity: Past, present, and future trends. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-04-06 Vasco Branco,Sam Caito,Marcelo Farina,João Teixeira da Rocha,Michael Aschner,Cristina Carvalho
Mercury (Hg) toxicity continues to represent a global health concern. Given that human populations are mostly exposed to low chronic levels of mercurial compounds (methylmercury through fish, mercury vapor from dental amalgams, and ethylmercury from vaccines), the need for more sensitive and refined tools to assess the effects and/or susceptibility to adverse metal-mediated health risks remains. Traditional
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The aging kidney and the nephrotoxic effects of mercury. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-03-25 Christy C Bridges,Rudolfs K Zalups
Owing to advances in modern medicine, life expectancies are lengthening and leading to an increase in the population of older individuals. The aging process leads to significant alterations in many organ systems, with the kidney being particularly susceptible to age-related changes. Within the kidney, aging leads to ultrastructural changes such as glomerular and tubular hypertrophy, glomerulosclerosis
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Is Triclosan a neurotoxic agent? J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-03-25 Joanna A Ruszkiewicz,Shaojun Li,Maliya B Rodriguez,Michael Aschner
Triclosan (TCS) is an antibacterial agent that has been used in many products since 1960s. Given its broad usage as an antiseptic TCS is present ubiquitously in the environment. Trace levels of TCS continue to be detected in many organisms, and it has been shown to be particularly toxic to aquatic species. The mechanisms underlying TCS-mediated toxicity include hormone dyshomeostasis, induction of
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Geological occurrence, mineralogical characterization, and risk assessment of potentially carcinogenic erionite in Italy. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-03-25 Matteo Giordani,Michele Mattioli,Paolo Ballirano,Alessandro Pacella,Marco Cenni,Matteo Boscardin,Laura Valentini
Erionite is a zeolite representing a well-known health hazard. In fact, exposure of humans to its fibers has been unequivocally associated with occurrence of malignant mesothelioma. For this reason, a multi-methodological approach, based upon field investigation, morphological characterization, scanning electron microscopy (SEM)/energy-dispersive spectroscopy (EDS) chemical analysis, and structure
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The role of micronutrients in the response to ambient air pollutants: Potential mechanisms and suggestions for research design. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-02-02 Colette N Miller,Srujana Rayalam
People living in regions of low socioeconomic status are thought to be prone to higher exposures to environmental pollutants, poor nutrition, and numerous preventable diseases and infections. Poverty correlates with pollution and malnutrition; however, limited studies examined their interrelationship. The well-studied, deleterious health effects attributed to environmental pollutants and poor nutrition
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Increased blood levels of persistent organic pollutants (POP) in obese individuals after weight loss-A review. J. Toxicol. Environ. Health B Crit. Rev. (IF 6.105) Pub Date : 2017-01-05 Aina Jansen,Jan L Lyche,Anuschka Polder,Jan Aaseth,Marit Aralt Skaug
Lipophilic persistent organic pollutants (POP) are stored in adipose tissue. Following rapid weight loss such as when induced by bariatric surgery, an increased release of potential harmful lipophilic compounds into the blood circulation may occur. Weight reduction is recommended for overweight and obese individuals in order to decrease risk of weight-related health problems. However, in cases of significant