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Bio-functional hydroxyapatite coated 3D porous polyetherketoneketone scaffold for enhanced osteogenesis and osteointegration in orthopedic applications Regen. Biomater. (IF 6.7) Pub Date : 2024-03-15 Huanhuan Liu, Taiqing Liu, Zhicheng Yin, Xiaoyin Liu, Ying Tan, Yuwei Zhao, Haiyang Yu
Polyetherketoneketone (PEKK), a high-performance thermoplastic special engineering material, maintains bone-like mechanical properties and has received considerable attention in the biomedical field. The three-dimensional (3D) printing technique enables the production of porous scaffolds with a honeycomb structure featuring precisely controlled pore size, porosity, and interconnectivity, which holds
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MRI-guided photothermal/photodynamic immune activation combined with PD-1 inhibitor for the multimodal combination therapy of melanoma and metastases Regen. Biomater. (IF 6.7) Pub Date : 2024-03-13 Changqiang Wu, Wei Chen, Shuang Yan, Jie Zhong, Liang Du, Chenwu Yang, Yu Pu, Yang Li, Jiafu Lin, Mei Zeng, Xiaoming Zhang
Non-invasive image-guided precise photothermal/photodynamic therapy (PTT/PDT) has been proven an effective local treatment modality, but incompetent against metastases. Hence the combination of local PTT/PDT and systemic immunotherapy would be a promising strategy for tumor eradication. Herein, a MRI-visualized PTT/PDT agent (SIDP NMs) was constructed, and the efficacy of its multimodal combination
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Antibacterial and antioxidant bifunctional hydrogel based on hyaluronic acid complex MoS2-dithiothreitol nanozyme for treatment of infected wounds Regen. Biomater. (IF 6.7) Pub Date : 2024-03-09 Yongping Lu, Weiqi Kang, Yue Yu, Ling Liang, Jinrong Li, Haiying Lu, Ping Shi, Mingfang He, Yuemin Wang, Jianshu Li, Xingyu Chen
Wound repair is a complex physiological process that often leads to bacterial infections, which significantly threaten human health. Therefore, developing wound-healing materials that promote healing and prevent bacterial infections is crucial. In this study, the coordination interaction between sulfhydryl groups on dithiothreitol (DTT) and MoS2 nanosheets is investigated to synthesize a MoS2-DTT nanozyme
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Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration Regen. Biomater. (IF 6.7) Pub Date : 2024-01-26 Kui Wang, Yongmei Ge, Yongshuai Yang, Zhenjian Li, Jiayi Liu, Yizebang Xue, Yuanjun Zhang, Xiangchao Pang, A H W Ngan, Bin Tang
Diabetes is one of the most prevalent diseases worldwide. The tissue regeneration of diabetes patients is known to be rather tricky as the result of vascular dysfunction, and this leads to various clinical complications including diabetic foot ulcers. The vascular endothelial cells compactly line the inner surface of blood vessels are responsible for the growth and maintenance of blood vessels, and
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Facile synthesis of Nanoparticles-Stacked Co3O4 nanoflakes with catalase-like activity for accelerating wound healing Regen. Biomater. (IF 6.7) Pub Date : 2024-01-26 Yanan Huang, Wanyi Liao, Wenxuan Wang, Tingting Zhang, Yan Zhang, Lei Lu
Delayed wound healing caused by excessive reactive oxygen species (ROS) remains a considerable challenge. In recent years, metal oxide nanozymes have gained significant attention in biomedical research. However, a comprehensive investigation of Co3O4 based nanozymes for enhancing wound healing and tissue regeneration is lacking. This study focuses on developing a facile synthesis method to produce
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Anisotropic microtopography surface of chitosan scaffold regulating skin precursor-derived schwann cells towards repair phenotype promotes neural regeneration Regen. Biomater. (IF 6.7) Pub Date : 2024-01-24 Meng Cong, Xia Wu, Ling-jie Zhu, Guo-hao Gu, Fei Ding, Gui-cai Li, Hai-yan Shi
For repairing peripheral nerve and spinal cord defects, biomaterial scaffold-based cell-therapy was emerged as an effective strategy, requiring the positive response of seed cells to biomaterial substrate and environment signals. Previous work highlighted that the imposed surface properties of scaffold could provide important guidance cues to adhered cells for polarization. However, the insufficiency
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Mild Synthesis of Ultra-Bright Carbon Dots with Solvatochromism for Rapid Lipid Droplet Monitoring in Varied Physiological Process Regen. Biomater. (IF 6.7) Pub Date : 2024-01-17 Borui Su, Dong Gao, Nini Xin, Kai Wu, Mei Yang, Shichao Jiang, Yusheng Zhang, Jie Ding, Chengheng Wu, Jing Sun, Dan Wei, Hongsong Fan, Zhenzhen Guo
Lipid droplets (LDs) participating in various cellular activities and are increasingly being emphasized. Fluorescence imaging Provides powerful tool for dynamic tracking of LDs, however, most current LDs probes remain inconsistent performance such as low Photoluminescence Quantum Yield (PLQY), poor photostability and tedious washing procedures. Herein, a novel yellow-emissive carbon dot (OT-CD) has
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Fe-Zn alloy, a new biodegradable material capable of reducing ROS and inhibiting oxidative stress Regen. Biomater. (IF 6.7) Pub Date : 2024-01-13 Shuaikang Yang, Weiqiang Wang, Yanan Xu, Yonghui Yuan, Shengzhi Hao
Fe-based biodegradable materials have attracted significant attention due to their exceptional mechanical properties and favorable biocompatibility. Currently, research on Fe-based materials mainly focuses on regulating the degradation rate. However, excessive release of Fe ions during material degradation will induce the generation of reactive oxygen species (ROS), leading to oxidative stress and
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Electrospun PCL/gelatin/arbutin nanofiber membranes as potent reactive oxygen species scavengers to accelerate cutaneous wound healing Regen. Biomater. (IF 6.7) Pub Date : 2024-01-13 Mindong Du, Shuhan Liu, Nihan Lan, Ruiming Liang, Shengde Liang, Maoqiang Lan, Disen Feng, Li Zheng, Qingjun Wei, Ke Ma
The presence of excessive reactive oxygen species (ROS) at a skin wound site is an important factor affecting wound healing. ROS scavenging, which regulates the ROS microenvironment, is essential for wound healing. In this study, we used novel electrospun PCL/gelatin/arbutin(PCL/G/A) nanofibrous membranes as wound dressings, with PCL/gelatin(PCL/G) as the backbone, and plant-derived arbutin (hydro
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Construction of millimeter-scale vascularized engineered myocardial tissue using a mixed gel Regen. Biomater. (IF 6.7) Pub Date : 2023-12-28 Ming Ke, Wenhui Xu, Yansha Hao, Feiyang Zheng, Guanyuan Yang, Yonghong Fan, Fangfang Wang, Zhiqiang Nie, Chuhong Zhu
Engineering myocardium has shown great clinal potential for repairing permanent myocardial injury. However, the lack of perfusing blood vessels and difficulties in preparing a thick engineered myocardium result in its limited clinical use. We prepared a mixed gel containing fibrin (5 mg/mL) and collagen I (0.2 mg/mL), and verified that human umbilical vein endothelial cells (HUVECs) and human induced
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Immediate implantation of ultrafine fiber slow-release system based on cell electrospinning to induce osteogenesis of mesenchymal stem cells Regen. Biomater. (IF 6.7) Pub Date : 2023-12-24 Tao Lu, Long Yang, Zhuo-yang Li, Yin Liu, Shun-en Xu, Chuan Ye
This study presents the development and evaluation of a P34HB ultrafine fiber slow-release system for in vivo osteogenic induction of Human Umbilical Cord Mesenchymal Stem Cells (HUCMSCs). Utilizing dual-nozzle and cell electrospinning techniques, the system encapsulates L-ascorbic acid-2-phosphate magnesium (ASP), β-glycerophosphate sodium (GP), and dexamethasone (DEX) within the fibers, ensuring
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Recent progress in functional metal organic frameworks for bio-medical application Regen. Biomater. (IF 6.7) Pub Date : 2023-12-23 Wenwen Chai, Xiaochen Chen, Jing Liu, Liyan Zhang, Chunyu Liu, Li Li, Honiball John Robert, Haobo Pan, Xu Cui, Deping Wang
Metal-organic frameworks (MOFs) have a high specific surface area, adjustable pores and can be used to obtain functional porous materials with diverse and well-ordered structures through coordination and self-assembly, which has intrigued wide interest in a broad range of disciplines. In the arena of biomedical engineering, the functionalized modification of MOFs has produced drug carriers with excellent
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Precision cardiac targeting: empowering curcumin therapy through smart exosome-mediated drug delivery in myocardial infarction Regen. Biomater. (IF 6.7) Pub Date : 2023-12-14 Ming Chen, Shengnan Wang, Yihuan Chen, Han Shen, Lei Chen, Liang Ding, Qingsong Tang, Ziying Yang, Weiqian Chen, Zhenya Shen
Nanoparticle-mediated drug delivery has emerged as a highly promising and effective therapeutic approach for addressing myocardial infarction. However, clinical translation tends to be a failure due to low cardiac retention as well as liver and spleen entrapment in previous therapies. Herein, we report a two-step exosome delivery system, which precludes internalization by the mononuclear phagocyte
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Effects of serum proteins on corrosion rates and product bioabsorbability of biodegradable metals Regen. Biomater. (IF 6.7) Pub Date : 2023-12-12 Hongjie Zhang, Xin Li, Zehua Qu, Wanqian Zhang, Qunsong Wang, Dinglingge Cao, Yaoben Wang, Xin Wang, Yang Wang, Lin Yu, Jiandong Ding
Corrodible metals are the newest kind of biodegradable materials and raise a new problem of the corrosion products. However, the removal of the precipitated products has been unclear and even largely ignored in publications. Herein, we find that albumin, an abundant macromolecule in serum enhances the solubility of corrosion products of iron in blood mimetic Hank’s solution significantly. This is universal
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Unveiling Protein Corona Composition: Predicting with Resampling Embedding and Machine Learning Regen. Biomater. (IF 6.7) Pub Date : 2023-12-12 Rong Liao, Yan Zhuang, Xiangfeng Li, Ke Chen, Xingming Wang, Cong Feng, Guangfu Yin, Xiangdong Zhu, Jiangli Lin, Xingdong Zhang
Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue regeneration. When nanoparticles (NPs) enter the living system, they quickly interact with proteins in the body fluid, forming the protein corona (PC). The accurate prediction of the PC composition is critical for analyzing the osteoinductivity of biomaterials and guiding the reverse design of NPs. However
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ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds Regen. Biomater. (IF 6.7) Pub Date : 2023-12-08 Bowen Qiao, Jiaxin Wang, Lipeng Qiao, Aziz Maleki, Yongping Liang, Baolin Guo
For the treatment of MRSA-infected wounds, the spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs is a promising strategy. In this study, ROS responsive HA-PBA/PVA (HPA) hydrogel was prepared by phenylborate ester bond cross-linking between hyaluronic acid grafted 3-aminophenylboronic acid (HA-PBA) and polyvinyl alcohol (PVA) to achieve spatiotemporally controlled release
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Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine Regen. Biomater. (IF 6.7) Pub Date : 2023-12-01 Peiyao Xu, Ranjith Kumar Kankala, Shibin Wang, Aizheng Chen
Despite the considerable advancements in fabricating polymeric-based scaffolds for tissue engineering, the clinical transformation of these scaffolds remained a big challenge because of the difficulty of simulating native organs/tissues' microenvironment. As a kind of natural tissue-derived biomaterials, decellularized extracellular matrix (dECM)-based scaffolds have gained attention due to their unique
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Status and Developmental Trends in Recombinant Collagen Preparation Technology Regen. Biomater. (IF 6.7) Pub Date : 2023-11-29 Xiaolei Guo, Yuan Ma, Hang Wang, Hongping Yin, Xinli Shi, Yiqin Chen, Guobiao Gao, Lei Sun, Jiadao Wang, Yunbing Wang, Daidi Fan
Recombinant collagen is a pivotal topic in foundational biological research and epitomizes the application of critical bioengineering technologies. These technological advancements have profound implications across diverse areas such as regenerative medicine, organ replacement, tissue engineering, cosmetics, and more. Thus, recombinant collagen and its preparation methodologies rooted in genetically
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Sol-gel derived B2O3-CaO borate bioactive glasses with hemostatic, antibacterial and pro-angiogenic activities Regen. Biomater. (IF 6.7) Pub Date : 2023-11-24 Kai Zheng, Faina Bider, Mahshid Monavari, Zhiyan Xu, Christina Janko, Christoph Alexiou, Ana Maria Beltrán, Aldo R Boccaccini
Sol-gel borate bioactive glasses (BGs) are promising ion-releasing biomaterials for wound healing applications. Here we report the synthesis of a series of binary B2O3-CaO borate BGs (Ca ranging from 50 to 90 mol%) using a sol-gel-based method. The influence of CaO content in B2O3-CaO borate BG on morphology, structure and ion release behavior was investigated in detail. Reduced dissolution (ion release)
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Tissue adhesive, ROS-scavenging and injectable PRP-based “plasticine” for promoting cartilage repair Regen. Biomater. (IF 6.7) Pub Date : 2023-11-21 Shiao Li, Dawei Niu, Haowei Fang, Yancheng Chen, Jinyan Li, Kunxi Zhang, Jingbo Yin, Peiliang Fu
Platelet-rich plasma (PRP) that has various growth factors has been used clinically in cartilage repair. However, the short residence time and release time at the injury site limit its therapeutic effect. The present study fabricated a granular hydrogel that assembled from gelatin microspheres and tannic acid (TA) through their abundant hydrogen bonding. Gelatin microspheres with the gelatin concentration
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Exogeneous Metal ions as therapeutic agents in cardiovascular disease and their delivery strategies Regen. Biomater. (IF 6.7) Pub Date : 2023-11-21 Xiaoqian Hong, Geer Tian, Yang Zhu, Tanchen Ren
Metal ions participate in many metabolic processes in the human body, and their homeostasis is crucial for life. In cardiovascular diseases (CVDs), the equilibriums of metal ions are frequently interrupted, which are related with a variety of disturbances of physiological processes leading to abnormal cardiac functions. Exogenous supplement of metal ions has the potential to work as therapeutic strategies
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Bioactive Citrate-based Polyurethane Tissue Adhesive for Fast Sealing and Promoted Wound Healing Regen. Biomater. (IF 6.7) Pub Date : 2023-11-20 Yan Li, Jiawei Liu, Chenxi Lian, He Yang, Mingjiang Zhang, Youfa Wang, Honglian Dai
As a superior alternative to sutures, tissue adhesives have been developed significantly in recent years. However, existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces, bond weakly in wet environments, and lack bioactivity. In this study, a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue adhesion
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Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant Regen. Biomater. (IF 6.7) Pub Date : 2023-11-17 Jing Zhang, Jie Wang, Jiayi You, Xuan Qin, Huimin Chen, Xiantong Hu, Yantao Zhao, Yang Xia
The removal of a failed implant with high torque causes significant damage to the surrounding tissue, compromising bone regeneration and subsequent osseointegration in the defect area. Here, we report a case of carrier screw fracture followed by immediate implant removal, bone grafting, and delayed reimplantation. A dental implant with a fractured central carrier screw was removed using the bur-forceps
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Dental-derived Stem Cells in Tissue Engineering: The Role of Biomaterials and Host Response Regen. Biomater. (IF 6.7) Pub Date : 2023-11-12 Weihao Yuan, Luiza de Almeida Queiroz Ferreira, Bo Yu, Sahar Ansari, Alireza Moshaverinia
Dental-derived stem cells (DSCs) are attractive cell sources due to their easy access, superior growth capacity, and low immunogenicity. They can respond to multiple extracellular matrix (ECM) signals, which provide biophysical and biochemical cues to regulate the fate of residing cells. However, the direct transplantation of DSCs suffers from poor proliferation and differentiation towards functional
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Electroconductivity, a Regenerative Engineering Approach to Reverse Rotator Cuff Muscle Degeneration Regen. Biomater. (IF 6.7) Pub Date : 2023-11-12 Nikoo Saveh Shemshaki, Mohammed A Barajaa, Takayoshi Otsuka, Elnaz S Mirdamadi, Lakshmi S Nair, Cato T Laurencin
Muscle degeneration is one the main factors that lead to the high rate of retear after a successful repair of rotator cuff tears. The current surgical practices have failed to treat patients with chronic massive rotator cuff tears. Therefore, regenerative engineering approaches are being studied to address the challenges. Recent studies showed the promising outcomes of electroactive materials on the
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NIR-switchable Local Hydrogen Generation by Tandem Bimetallic MOFs Nanocomposites for Enhanced Chemodynamic Therapy Regen. Biomater. (IF 6.7) Pub Date : 2023-11-06 Jun Zhong, Xiang Zheng, Yuan Wen, Yuewei Li, Jianting Zhang, Ranjith Kumar Kankala, Shibin Wang, Aizheng Chen
The inadequate quantity of hydrogen peroxide (H2O2) in cancer cells promptly results in the constrained success of chemodynamic therapy (CDT). Significant efforts made throughout the years, nevertheless, researchers are still facing the great challenge of designing a CDT agent and securing H2O2 supply within the tumor cell. In this study, taking advantage of H2O2 level maintenance mechanism in cancer
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Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway Regen. Biomater. (IF 6.7) Pub Date : 2023-11-06 Xi Hua, Mingzhuang Hou, Lei Deng, Nanning Lv, Yong Xu, Xuesong Zhu, Huilin Yang, Qin Shi, Hao Liu, Fan He
The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone defects. The challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture site. However, the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical
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Magnesium-based alloys with adapted interfaces for bone implants and tissue engineering Regen. Biomater. (IF 6.7) Pub Date : 2023-11-06 Iulian Antoniac, Veronica Manescu (Paltanea), Aurora Antoniac, Gheorghe Paltanea
Magnesium and its alloys are one of the most used materials for bone implants and tissue engineering. They are characterized by numerous advantages such as biodegradability, high biocompatibility, and mechanical properties with values close to the human bone. Unfortunately, the implant surface must be adequately tuned, or Mg-based alloys must be alloyed with other chemical elements due to their increased
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Vascularization ability of glioma stem cells in different three-dimensional microenvironments Regen. Biomater. (IF 6.7) Pub Date : 2023-10-25 Xuanzhi Wang, Tao Xu, Chaoshi Niu
Glioblastoma (GBM) is among the most common and aggressive adult central nervous system tumors. One prominent characteristic of GBM is the presence of abnormal microvessels. A significant correlation between angiogenesis and prognosis has been observed. Accurately reconstructing this neovascularization and tumor microenvironment through personalized in vitro disease models presents a significant challenge
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Poly(L-lactic acid)-based double-layer composite scaffold for bone tissue repair Regen. Biomater. (IF 6.7) Pub Date : 2023-10-25 Yixing Ren, Chunyang Ma, Yao Yu, Dandan Yang, Lingling Zhang, Huitao Wang, Lei Sun
Bone defect is a serious threat to human health. Osteopractic total flavone (OTF) extracted from Rhizoma Drynariae has the effects of promoting bone formation. Panax notoginseng saponin (PNS) has the function of activating blood circulation and removing blood stasis. Therefore, combining OTF and PNS with Poly(L-lactic acid) (PLLA) to prepare scaffolds containing PNS in the outer layer and OTF in the
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Polyurethane scaffold-based 3D lung cancer model recapitulates in vivo tumor biological behavior for nanoparticulate drug screening Regen. Biomater. (IF 6.7) Pub Date : 2023-10-24 Lu Sun, Xiaofei Wang, Yushui He, Boran Chen, Baoyin Shan, Jinlong Yang, Ruoran Wang, Xihang Zeng, Jiehua Li, Hong Tan, Ruichao Liang
Lung cancer is the leading cause of cancer mortality worldwide. Preclinical studies in lung cancer hold the promise of screening for effective anti-tumor agents, but mechanistic studies and drug discovery based on 2D cell models have a high failure rate in getting to the clinic. Thus, there is an urgent need to explore more reliable and effective in vitro lung cancer models. Here, we prepared a series
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Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NF-κB signaling pathway Regen. Biomater. (IF 6.7) Pub Date : 2023-10-23 Zhidong Wang, Huaqiang Tao, Miao Chu, Lei Yu, Peng Yang, Qiufei Wang, Jun Lu, Huilin Yang, Zhenheng Wang, Hailin Zhang, Dechun Geng
Aseptic loosening (AL) is considered a significant cause of prosthesis revision after arthroplasty and a crucial factor in the longevity of an artificial joint prosthesis. The development of AL is primarily attributed to a series of biological reactions, such as peri-prosthetic osteolysis (PPO) induced by wear particles around the prosthesis. Chronic inflammation of the periprosthetic border tissue
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Development of Photoreactive Demineralized Bone Matrix 3D-Printing Colloidal Inks for Bone Tissue Engineering Regen. Biomater. (IF 6.7) Pub Date : 2023-10-19 Katie J Hogan, Hayriye Öztatlı, Marissa Perez, Sophia Si, Reyhan Umurhan, Elysa Jui, Ziwen Wang, Emily Jiang, Sa Han, Mani Diba, K Jane Grande-Allen, Bora Garipcan, Antonios G Mikos
Demineralized bone matrix (DBM) has been widely used clinically for dental, craniofacial, and skeletal bone repair, as an osteoinductive and osteoconductive material. 3D-printing (3DP) enables the creation of bone tissue engineering scaffolds with complex geometries and porosity. Photoreactive methacryloylated gelatin nanoparticles (GNP-MAs) 3DP inks have been developed, which display gel-like behavior
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The influence of tag-sequence on recombinant humanized collagen (rhCol) and the evaluation of rhCol on schwann cell behaviors Regen. Biomater. (IF 6.7) Pub Date : 2023-10-16 Mingxuan Bai, Ning Kang, Yang Xu, Jing Wang, Xinxing Shuai, Caojie Liu, Yixuan Jiang, Yu Du, Ping Gong, Hai Lin, Xingdong Zhang
Recombinant humanized collagen was an extracellular matrix (ECM)-inspired biomimetic biomaterial and prepared by biosynthesis technology, which was considered as non-allergenic and could possibly activate tissue regeneration. The influence of tag sequence on both structures and performances of recombinant humanized collagen type III (rhCol III) was investigated, and the effect of rhCol III on cell
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VEGF combined with DAPT promotes tissue regeneration and remodeling in vascular grafts Regen. Biomater. (IF 6.7) Pub Date : 2023-10-13 Tao Yang, Guangxu Li, Xifeng Li, Boyang Wei, Hengxian Su, Wenchao Liu, Shenquan Guo, Nan Yang, Tao Xu, Chuanzhi Duan
Previous research on tissue-engineered blood vessels (TEBVs) has mainly focused on the intima or adventitia unilaterally, neglecting the equal importance of both layers. Meanwhile, the efficacy of grafts modified with vascular endothelial growth factor (VEGF) merely has been limited. Here, we developed a small-diameter graft that can gradually release VEGF and DAPT (also named γ secretase inhibitor
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Mesoporous polydopamine delivery system for intelligent drug release and photothermal-enhanced chemodynamic therapy using MnO2 as gatekeeper Regen. Biomater. (IF 6.7) Pub Date : 2023-09-20 Zhaoyang Wang, Zekai Li, Yuehua Shi, Leyong Zeng
The non-specific leakage of drugs from nanocarriers seriously weakened the safety and efficacy of chemotherapy, and it was very critical of constructing tumor microenvironment (TME)-responsive delivery nanocarriers, achieving the modulation release of drugs. Herein, using manganese dioxide (MnO2) as gatekeeper, an intelligent nanoplatform based on mesoporous polydopamine (MPDA) was developed to deliver
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Tetrahedral framework nucleic acids enhance the chondrogenic potential of human umbilical cord mesenchymal stem cells via the PI3K/AKT axis Regen. Biomater. (IF 6.7) Pub Date : 2023-09-13 Liwei Fu, Pinxue Li, Jiang Wu, Yazhe Zheng, Chao Ning, Zhiyao Liao, Xun Yuan, Zhengang Ding, Zhichao Zhang, Xiang Sui, Sirong Shi, Shuyun Liu, Quanyi Guo
The field of regenerative medicine faces a notable challenge in terms of the regeneration of articular cartilage. Without proper treatment, it can lead to osteoarthritis. Based on the research findings, human umbilical cord mesenchymal stem cells (hUMSCs) are considered an excellent choice for regenerating cartilage. However, there is still a lack of suitable biomaterials to control their ability to
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Micro-porous PLGA/β-TCP/TPU scaffolds prepared by solvent-based 3D printing for bone tissue engineering purposes Regen. Biomater. (IF 6.7) Pub Date : 2023-09-12 Luan P Hatt, Sylvie Wirth, Aapo Ristaniemi, Daniel J Ciric, Keith Thompson, David Eglin, Martin J Stoddart, Angela R Armiento
The 3D printing process of fused deposition modelling (FDM) is an attractive fabrication approach to create tissue engineered bone substitutes to regenerate large mandibular bone defects, but often lacks desired surface porosity for enhanced protein adsorption and cell adhesion. Solvent-based printing leads to the spontaneous formation of micropores on the scaffold’s surface upon solvent removal, without
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Biomaterials combined with ADSCs for bone tissue engineering: current advances and applications Regen. Biomater. (IF 6.7) Pub Date : 2023-09-11 Yiping Song, Ning Wang, Huixin Shi, Dan Zhang, Qiang Wang, Shu Guo, Shude Yang, Jia Ma
In recent decades, bone tissue engineering (BTE), which is supported by scaffold, seed cells, and bioactive molecules (BMs), has provided new hope and direction for treating bone defects. In terms of seed cells, compared to bone marrow mesenchymal stem cells (BMSCs), which were widely utilized in previous years, adipose-derived stem cells (ADSCs) are becoming increasingly favored by researchers due
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Double-crosslinked PNIPAM-based hydrogel dressings with adjustable adhesion and contractility Regen. Biomater. (IF 6.7) Pub Date : 2023-09-09 Yu Cao, Longfei Wang, Xiumei Zhang, Yi Lu, Yan Wei, Ziwei Liang, Yinchun Hu, Di Huang
Rapid post-wound closure is necessary to avoid wound infection and promote scar-free healing when skin trauma occurs. In this study, new types of hydrogel dressings with adjustable contractility were fabricated based on N-isopropyl acrylamide/sodium alginate/graphene oxide (P/SA/GO). Then, the chitosan (CS) solution was used as a bridging polymer to achieve tissue adhesion to the hydrogel. The results
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A construct of adipose-derived mesenchymal stem cells–laden collagen scaffold for fertility restoration by inhibiting fibrosis in a rat model of endometrial injury Regen. Biomater. (IF 6.7) Pub Date : 2023-09-06 Yangyang Dai, Liaobing Xin, Sentao Hu, Shiqian Xu, Dong Huang, Xiaoying Jin, Jianmin Chen, Rachel Wah Shan Chan, Ernest Hung Yu Ng, William Shu Biu Yeung, Lie Ma, Songying Zhang
Severe endometrium damage causes pathological conditions such as thin endometrium and intrauterine adhesion, resulting in uterine factor infertility. Mesenchymal stem cell (MSC) therapy is a promising strategy in endometrial repair, yet exogenous MSCs still raise concerns for safety and ethical issues. Human adipose-derived mesenchymal stem cells (ADMSCs) residing in adipose tissue have high translational
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Chondrogenic Medium in Combination with a c-Jun N-Terminal Kinase Inhibitor Mediates Engineered Cartilage Regeneration by Regulating Matrix Metabolism and Cell Proliferation Regen. Biomater. (IF 6.7) Pub Date : 2023-09-06 Peiling Zhang, Qianyi Wang, Jie Chen, Zheng Ci, Wei Zhang, Yu Liu, Xiaoyun Wang, Guangdong Zhou
Cartilage tissue engineering is a promising strategy for repairing cartilage defects. However, achieving satisfactory cartilage regeneration in vitro and maintaining its stability in vivo remains a challenge. The key to achieving this goal is establishing an efficient cartilage regeneration culture system to retain sufficient active cells with physiological functions, generate abundant cartilage extracellular
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Albumin-based nanosystem for dual-modality imaging-guided chem-phototherapy against immune-cold triple-negative breast cancer. Regen. Biomater. (IF 6.7) Pub Date : 2023-08-31 Chen Peng,Xiaodie Zeng,Jiali Cai,Hanyu Huang,Fan Yang,Shaowen Jin,Xiuhong Guan,Zhiyong Wang
Triple-negative breast cancer is a highly aggressive and metastatic tumor; diagnosing it in the early stages is still difficult, and the prognosis for conventional radio-chemotherapy and immunotreatment is not promising due to cancer's immunosuppressive microenvironment. The utilization of protein-based nanosystem has proven to be effective in delivering agents with limited adverse effects, yet the
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Photothermal effective CeO2NPs combined in thermosensitive hydrogels with enhanced antibacterial, antioxidant, and vascularization performance to accelerate infected diabetic wound healing Regen. Biomater. (IF 6.7) Pub Date : 2023-08-31 Zexiang Zheng, Xing Yang, Min Fang, Jinhuan Tian, Shuyun Zhang, Lu Lu, Changren Zhou, Changpeng Xu, Yong Qi, Lihua Li
Chronic diabetic wound healing remains a formidable challenge due to susceptibility to bacterial infection, excessive oxidative stress, and poor angiogenesis. To address these issues, a sodium alginate (SA) based photothermal hydrogel dressing with multifunction was fabricated to facilitate wound treatment. Ceria nanoparticles (CeO2NPs) was synthesized, and their antibacterial performance by near-infrared
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MicroRNA-21a-5p-modified macrophage exosomes as natural nanocarriers promote bone regeneration by targeting GATA2 Regen. Biomater. (IF 6.7) Pub Date : 2023-08-31 Xin Luo, Chunxiu Meng, Yujue Zhang, Qicui Du, Caiyao Hou, Huifen Qiang, Kun Liu, Zhaoyong Lv, Jun Li, Fengzhen Liu
Bone immune responses based on macrophages are critical in the osteogenesis of bone abnormalities. In general, M2 macrophage facilitate the promotion of osteogenesis, as well, M1 macrophage play an important role in early bone healing, as confirmed by previous studies. However, it is not clear how M1 macrophage are involved in the bone immune response. MiR-21a-5p is a highly expressed microRNA in M1
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Mitochondrial-targeting Mn3O4/UIO-TPP nanozyme scavenge ROS to restore mitochondrial function for osteoarthritis therapy Regen. Biomater. (IF 6.7) Pub Date : 2023-08-30 Shengqing Zhang, Jinhong Cai, Yi Yao, Lanli Huang, Li Zheng, Jinmin Zhao
Excessive reactive oxygen species (ROS)-induced mitochondrial damage has impact on osteoarthritis (OA). Nanozyme mimics as natural enzyme alternatives to scavenge excessive ROS has offered a promising strategy for OA therapy. Herein, we reported a novel mitochondrial-targeting Mn3O4/UIO-TPP nanozyme using metal-organic frameworks (MOFs) with loaded Mn3O4 as the enzyme-like active core combining mi
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Adhesive ginsenoside compound K patches for cartilage tissue regeneration Regen. Biomater. (IF 6.7) Pub Date : 2023-08-30 Jun-Ho Yang, Hyun Ho Shin, Donghyeon Kim, Ji Hyun Ryu, Eun-Jung Jin
Biomaterial-based drug delivery systems have been developed to expedite cartilage regeneration; however, challenges related to drug recovery, validation, and efficient drug delivery remain. For instance, compound K (CK) is a major metabolite of ginsenosides that is known to protect against joint degeneration by inhibiting the production of inflammatory cytokines and the activation of immune cells.
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Incorporation of kartogenin and silk fibroin scaffolds promotes rat articular cartilage regeneration through enhancement of antioxidant functions Regen. Biomater. (IF 6.7) Pub Date : 2023-08-30 Zejun Pan, Mingzhuang Hou, Yijian Zhang, Yang Liu, Xin Tian, Xiayu Hu, Xiaoyang Ge, Zhijian Zhao, Tao Liu, Yong Xu, Huilin Yang, Hao Liu, Xuesong Zhu, Fan He
Treating articular cartilage defects in patients remains a challenging task due to the absence of blood vessels within the cartilage tissue. The regenerative potential is further compromised by an imbalance between anabolism and catabolism, induced by elevated levels of reactive oxygen species (ROS). However, the advent of tissue engineering introduces a promising strategy for cartilage regeneration
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NIR-responsive Carrier-free Nanoparticles based on Berberine Hydrochloride and Indocyanine Green for Synergistic Antibacterial Therapy and Promoting Infected Wound Healing Regen. Biomater. (IF 6.7) Pub Date : 2023-08-29 You-Yu Duan, Pei-Yao Xu, Pan-Yuan Ge, Lin-Fei Chen, Ying Chen, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
Bacterial infections cause severe health conditions, resulting in a significant economic burden for the public health system. Although natural phytochemicals are considered promising anti-bacterial agents, they suffer from several limitations, such as poor water solubility and low bioavailability in vivo, severely restricting their wide application. Herein, we constructed a near-infrared (NIR)-responsive
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Sprayed PAA-CaO2 nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing Regen. Biomater. (IF 6.7) Pub Date : 2023-08-21 Hong Yu, Jiale Sun, Kepeng She, Mingqi Lv, Yiqiao Zhang, Yawen Xiao, Yangkun Liu, Changhao Han, Xinyue Xu, Shuqing Yang, Guixue Wang, Guangchao Zang
The most common socioeconomic healthcare issues in clinical are burns, surgical incisions, and other skin injuries. Skin lesion healing can be achieved with nanomedicines and other drug application techniques. This study developed a nano-spray based on cross-linked amorphous calcium peroxide (CaO2) nanoparticles of polyacrylic acid (PAA) for treating skin wounds (PAA-CaO2 nanoparticles). CaO2 serves
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A controllable gelatin-based microcarriers fabrication system for the whole procedures of MSCs amplification and tissue engineering Regen. Biomater. (IF 6.7) Pub Date : 2023-08-13 Zixian Wang, Xiuxiu Zhang, Limin Xue, Gangwei Wang, Xinda Li, Jianwei Chen, Ruxiang Xu, Tao Xu
Biopolymer microbeads present substantial benefits for cell expansion, tissue engineering, and drug release applications. However, a fabrication system capable of producing homogeneous microspheres with high precision and controllability for cell proliferation, passaging, harvesting and downstream application is limited. Therefore, we developed a co-flow microfluidics-based system for the generation
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Mitochondria as a Therapeutic: A Potential New Frontier in Driving the Shift from Tissue Repair to Regeneration Regen. Biomater. (IF 6.7) Pub Date : 2023-08-12 Evan N Main, Thaiz M Cruz, Gary L Bowlin
Fibrosis, or scar tissue development, is associated with numerous pathologies and is often considered a worst-case scenario regarding wound healing or the implantation of a biomaterial. A disorganized, densely packed, and poorly vascularized bundle of connective tissue is all that remains of once functional tissue, creating a significant obstacle to the return of tissue function or integration with
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Nature-inspired nanocarriers for improving drug therapy of atherosclerosis Regen. Biomater. (IF 6.7) Pub Date : 2023-08-12 Weihong Ji, Yuanxing Zhang, Yuanru Deng, Changyong Li, Ranjith Kumar Kankala, Ai-Zheng Chen
Atherosclerosis (AS) has emerged as one of the prevalent arterial vascular diseases characterized by plaque and inflammation, primarily causing disability and mortality globally. Drug therapy remains the main treatment for AS. However, a series of obstacles hinder effective drug delivery. Nature, from natural micro-/nano-structural biological particles like natural cells and extracellular vesicles
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Construction of 3D bioprinting of HAP/collagen scaffold in gelation bath for bone tissue engineering Regen. Biomater. (IF 6.7) Pub Date : 2023-08-12 Chuang Guo, Jiacheng Wu, Yiming Zeng, Hong Li
Reconstruction of bone defects remains a clinical challenge, and 3D bioprinting is a fabrication technology to treat it via tissue engineering. Collagen is currently the most popular cell scaffold for tissue engineering; however, a shortage of printability and low mechanical strength limited its application via 3D bioprinting. In the study, aiding with a gelatin support bath, a collagen-based scaffold
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Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration. Regen. Biomater. (IF 6.7) Pub Date : 2023-07-21 Rinat Nigmatullin,Caroline S Taylor,Pooja Basnett,Barbara Lukasiewicz,Alexandra Paxinou,Lorena R Lizarraga-Valderrama,John W Haycock,Ipsita Roy
Polyhydroxyalkanoates are natural, biodegradable, thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue engineering. We describe a comparative evaluation of three medium chain length polyhydroxyalkanoates (mcl-PHAs), namely poly(3-hydroxyoctanoate), poly(3-hydroxyoctanoate-co-3-hydoxydecanoate) and poly(3-hydroxyoctanoate-co-3-h
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Enhancing cell adhesive and antibacterial activities of glass-fibre-reinforced polyetherketoneketone through Mg & Ag PIII Regen. Biomater. (IF 6.7) Pub Date : 2023-07-12 Xin Tan, Zhongyi Wang, Xin Yang, Ping Yu, Manlin Sun, Yuwei Zhao, Haiyang Yu
Glass-fibre-reinforced polyetherketoneketone (PEKK-GF) shows great potential for application as a dental implant restoration material; however, its surface bioinertness and poor antibacterial properties limit its integration with peri-implant soft tissue, which is critical in the long-term success of implant restoration. Herein, functional magnesium (Mg) and silver (Ag) ions were introduced into PEKK-GF
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Correction to: Tissue engineering using 3D printed nano-bioactive glass loaded with NELL1 gene for repairing alveolar bone defects. Regen. Biomater. (IF 6.7) Pub Date : 2023-07-04
[This corrects the article DOI: 10.1093/rb/rby015.].
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3D-printed porous functional composite scaffolds with polydopamine decoration for bone regeneration. Regen. Biomater. (IF 6.7) Pub Date : 2023-06-21 Jin Qi,Yili Wang,Liping Chen,Linjie Chen,Feng Wen,Lijiang Huang,Pfukwa Rueben,Chunwu Zhang,Huaqiong Li
Large size bone defects affect human health and remain a worldwide health problem that needs to be solved immediately. 3D printing technology has attracted substantial attention for preparing penetrable multifunctional scaffolds to promote bone reconditioning and regeneration. Inspired by the spongy structure of natural bone, novel porous degradable scaffolds have been printed using polymerization
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A review of hydrogels used in endoscopic submucosal dissection for intraoperative submucosal cushions and postoperative management Regen. Biomater. (IF 6.7) Pub Date : 2023-06-21 Zhihong Chen, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Zhenzhen Guo
Endoscopic submucosal dissection (ESD) has been clinically proven to have prominent advantages in the treatment of early gastrointestinal cancers over traditional surgery, including less trauma, fewer complications, a quicker recovery, and lower costs. During the procedure of ESD, appropriate and multifunctional submucosal injected materials (SIMs) as submucosal cushions play an important role, however
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Biomimetic, biodegradable, and osteoinductive treated dentin matrix/α-calcium sulphate hemihydrate composite material for bone tissue engineering Regen. Biomater. (IF 6.7) Pub Date : 2023-06-19 Runying Guo, Rui Zhang, Sirui Liu, Yanyu Yang, Wenhang Dong, Meiyue Wang, Hongyan Mi, Mengzhe Liu, Jingjing Sun, Xue Zhang, Yimeng Su, Yiming Liu, Di Huang, Rui Li
It is still huge challenge for bone regenerative biomaterial to balance its mechanical, biological and biodegradable properties. In the present study, a new composite material including treated dentin matrix (TDM) and α-Calcium sulfate hemihydrate (α-CSH) was prepared. The optimal composition ratio between TDM and α-CSH was explored. The results indicate that both components were physically mixed and