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Application of blood purification technology in severe fever with thrombocytopenia syndrome Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-30 Hongxia Gao, Baoyin Wang, Hui Yao, Wenjie Zhang, HaiFeng Teng
ABSTRACT Objective: The purpose of this paper is to summarize the blood purification technology applied in patients with severe fever with thrombocytopenia syndrome (SFTS) in the clinical treatment effect. Methods: The medical records of 96 patients with severe SFTS admitted to Weihai Municipal Hospital affiliated to Shandong University from May 2014 to November 2019 were retrospectively analyzed,
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LINC00460 contributes to colorectal cancer cell invasion Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-30 Weiguo Ren, Xuexiu Zhang, Qiang Li, Chibin Pu
ABSTRACT Research background: Colorectal cancer (CRC) is one of the most prevalent malignant tumors in the world. Research on long noncoding RNAs (LncRNAs) may illuminate tumorigenesis and progression of CRC. Methods: We screened long non-coding RNA LINC00460 as a new candidate, which promoted the development of CRC in two independent datasets (GSE39582 and GSE21510) from the Gene Expression Omnibus
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CDCA7 serves as a novel prognostic marker in human hepatocellular carcinoma Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-29 Yuan Tian, Wenwen Han, Long Fu, Kaiji Lv, Shugeng Wu
ABSTRACT c-Myc oncogene plays an important role in tumorigenesis, cell division cycle associated 7 (CDCA7), recently found that it is a direct target gene of c-Myc, is upregulated in many tumors, but its role in tumor progression is still poorly understood. CDCA7 expression and prognosis were analyzed in hepatocellular carcinoma using TIMER2.0 and Kaplan–Meier databases, while genomic changes were
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Effect of interventional embolization based on absolute ethanol for peripheral arteriovenous malformations Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-29 Yanlin Wang, Dakan Liu, Li Xiao, Song Zuo, Tengfei Ren, Changxian Dong, Tianxiao Li
ABSTRACT Background Interventional embolization schedules based on absolute ethanol are usually used for peripheral arteriovenous malformations (PAVMs), and clinicians often choose the scheme according to the classification. Aim To evaluate different interventional embolization schedules based on absolute ethanol for PAVMs. Methods A retrospective study was performed of 165 patients with PAVMs treated
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A Prospective and Randomized Control Study on Effects of Thymalfasin for Injection on Perioperative Immune Function and Long-term Prognosis of Patients with Colorectal Cancer Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-29 Wenbo Niu, Zhiying Li, Zhihan Li, Xuhua Hu, Xiaoran Wang, Yuanyi Ding, Chenhui Li, Bin Yu
ABSTRACT The objective of this study is to explore the effects of thymalfasin for injection on perioperative immune function and long-term prognosis of patients with colorectal cancer (CRC). In total, 400 patients who entered the groups from February 2019 to January 2021 and underwent radical resection of CRC in the Fourth Hospital of Hebei Medical University were the study subjects. They were separated
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Effect and imaging analysis of cetuximab combined with radiotherapy in patients with rectal carcinoma Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-29 Shuai Zhang, Liangliang Liu, Shuguang Li, Xin Sun
ABSTRACT Objective. To analyze the effect of cetuximab combined with radiotherapy in patients with rectal carcinoma (RC) by imaging analysis. Methods. The clinical data of 104 RC patients at our hospital from February 2021 to February 2022 were retrospectively analyzed. They were separated into control group (n = 52) and experimental group (n = 52) according to the order of admission, with the former
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Progress in clinical characteristics of high myopia with primary open-angle glaucoma Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-27 Yao Lu, Zhi Ji, Jun Jia, Rui Shi, Ying Liu, Qiong Shu, Fulin Lu, Teng Ge, Yuan He
ABSTRACT High myopia (HM) is a significant risk factor for the occurrence and progression of primary open-angle glaucoma (POAG). Identification with POAG in the HM population is an emergent challenge. Patients with HM have a significantly higher probability of complicating POAG than those without HM. When HM is associated with POAG, the changes to the fundus caused by both of them are confused with
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Fabrication of ZnO/Gypsum/Gelatine nanocomposites films and their antibacterial mechanism against Staphylococcus aureus Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-27 Susanta Kumar Behera, Mashael Huwaikem, Bhumika Jena, Maulin P Shah, Sankha Chakrabortty, Suraj K. Tripathy, Amrita Mishra
ABSTRACT Staphylococcus aureus (S. aureus) has long been acknowledged as being one of the most harmful bacteria for human civilization. It is the main contributor to skin and soft tissue infections. The gram positive pathogen also contributes to bloodstream infections, pneumonia, or bone and joint infections. Hence, developing an efficient and targeted treatment for these illnesses is greatly desired
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Integrated bioinformatics analysis for exploring hub genes and related mechanisms affecting the progression of gastric cancer Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-27 Yu Wang, Di Li, Dan Li, Honglei Wang, Yu Wu
ABSTRACT Objective Gastric cancer (GC) is a high-risk tumor disease worldwide. The goal of the current study was to explore new diagnostic and prognostic indicators for gastric cancer. Methods Database GSE19826 and GSE103236 were gained from the Gene Expression Omnibus (GEO) to screen for differentially expressed genes (DEGs), which were then grouped together as co-DEGs. GO and KEGG pathway analysis
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LincRNA PRNCR1 activates the Wnt/β-catenin pathway to drive the deterioration of hepatocellular carcinoma via regulating miR-411-3p/ZEB1 axis Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-27 Pingsheng Zhou, Yang Liu, Guangzhen Wu, Kai Lu, Teng Zhao, Lixue Yang
ABSTRACT Hepatocellular carcinoma (HCC) is an intractable malignant disease with high incidence rate annually. LincRNA PRNCR1 has been confirmed as a tumor supporter, while its functions in HCC remain unclear. This study aims to explore the mechanism of LincRNA PRNCR1 in hepatocellular carcinoma. The qRT-PCR was applied to the quantification of non-coding RNAs. Cell counting Kit-8 (CCK-8), Transwell
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Application of CECT, CEMRI, and contrast-enhanced ultrasonography in the evaluation of renal cystic lesions: a systematic review and meta-analysis of retrospective studies Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-27 Peipei Feng, Libo Yu, Peng Liang
ABSTRACT The purpose of this meta-analysis was to investigate the role and effect of CECT, CEMRI and CEUS in the detection of renal cystic lesions, and to provide evidence-based basis for clinical examination and treatment. The Cochrane Library, EMBASE, and PUBMED databases were searched from January 2012 to December 2022 for article retrieval. The articles on the treatment of cystic renal disease
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Study on the effect and mechanisms of piperine against cervical cancer based on network pharmacology and experimental validation Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-26 Hui Cheng, Yanyu Li, Jie Cheng, Yanling Zhang, Bei Zhang
ABSTRACT Piperine has immunomodulatory and anti-inflammatory properties, and its potential in treating cervical cancer needs further exploration. Using data from The Cancer Genome Atlas (TCGA), we identified immune-related differentially expressed genes (IRDEGs) in cervical cancer. Predicted targets of piperine were compared with cervical cancer-associated genes from various databases. Protein-protein
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Endophytic fungi associated with Brucea mollis Wall. ex Kurz.: a hidden source of antimicrobial and antioxidant metabolites Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-26 Deepanwita Deka, Dhruva Kumar Jha
ABSTRACT Geosmithia pallida (KU693285) was isolated from Brucea mollis an endangered medicinal plant of North-East India. The secondary metabolites, produced by the endophytic fungi, extracted by ethyl acetate were screened for antimicrobial activity. G. pallida extract displayed the highest antimicrobial activity against Candida albicans with a minimum inhibitory concentration of 80.5 ± 1.25 µg/mL
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A meta-analysis of the effectiveness and safety of safinamide for levodopa-induced motor complications in Parkinson’s disease Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-26 Jiaojiao Li, Jianyu Zhang, Pin Meng
ABSTRACT To systematically evaluate the effectiveness and safety of safinamide in the treatment of levodopa-induced motor complications of Parkinson’s disease (PD). A search strategy was developed and PubMed, Embase, Web of Science, Cochrane Library, Chinese BioMedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), and WanFang Data were searched to find randomized controlled
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Based on P (cv-a) CO2/C (a-cv) O2 and its changes are associated with an early reduction in multiple organ failure in patients with septic hyperlactocidemia Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-25 Dan Lv, Changqing Zhu, Keji Zhang
ABSTRACT The study aimed to investigate the relationship between the respiratory quotient (RQ), measured by the central venous-arterial carbon dioxide partial pressure difference/arterial-venous oxygenation difference ratio, and the early remission of multi-organ failure (MOF) in sepsis patients with hyperlactatemia. The study observed 49 septic patients with hyperlactatemia in the ICU, obtaining blood
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Protective effect of dihydromyricetin against lipopolysaccharide-induced HK2 cells by upregulating HIF-1α Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-25 Jiang Chen, Chao Xie, Zhen Yu
ABSTRACT Sepsis complicated by acute kidney injury (AKI) carries an extremely high mortality rate. The present study aimed to investigate the protective effect and underlying mechanism of dihydromyricetin (DHM) on human renal tubular epithelial cells (HK2) during AKI. To simulate an in vitro model of AKI, HK2 cells were treated with lipopolysaccharide (LPS) and divided into four groups: Control, LPS
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Synthesis, characterization and application of BR@Ag nanocomposite material for high degree reduction of p-nitro phenol under a suitable condition Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-25 Fatimah Othman Alqahtani, Nazish Parveen, Gausal A. Khan, Meerambika Behera, Sankha Chakrabortty, Suraj K. Tripathy
ABSTRACT One of the most essential chemical processes that is utilized in the manufacturing of a great deal of contemporary goods is called heterogeneously catalyzed reactions, and it is also one of the most fascinating. Metallic nanostructures are heterogeneous catalysts for range reactions due to their huge surface area, large assembly of active surface sites, and quantum confinement effects. Unprotected
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Exploring the potential of lactic acid bacteria and its molecular mechanism of action in the development of biosurfactants: Current finding and future outlook Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-25 Babita Thakur, Sukhminderjit Kaur, Manikant Tripathi, Sudhir K. Upadhyay
ABSTRACT Biosurfactants generated from lactic acid bacteria (LAB) offer an advantage over standard microbial surfactants due to their antifungal, antibacterial and antiviral capabilities. Many LAB strains have been related to the manufacture of biosurfactant, an essential chemical with uses in the treatment of a number of illnesses. Furthermore, their effectiveness as anti-adhesive agents against a
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Analysis of genetic test results in 378 patients suspected of thalassaemia Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-24 Jing Jin, Weiying Feng, Zehao Fang, Jiaping Fu, Hongqiang Luo, Pan Hong, Li Hong, Lin Zhang
ABSTRACT Objective To analyze the genetic test results of 378 patients suspected of thalassemia. Methods 378 suspected thalassemia patients in Shaoxing People's Hospital from 2014 to 2020 were selected and venous blood was tested using Gap-PCR and PCR-reversed dot blottin. The distribution of genotypes and other information of gene-positive patients was observed. Results Thalassemia genes were detected
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Effect of acute hypervolemic hemodilution with bicarbonated Ringer’s solution on perioperative S100β and NSE in elderly patients undergoing spine surgery Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-24 Heng Wang, Changsen Lin, Wenhong Zhang, Fujiang Wei, Yong Xu, Chenghai Wang
ABSTRACT To explore the effect of acute hypervolemic hemodilution (AHH) with bicarbonated Ringer’s solution (BRS) on perioperative serum S100β protein (S100β) and neuron-specific enolase (NSE) in elderly patients undergoing spine surgery. Ninety patients with lumbar spondylolisthesis and fracture surgery admitted to our hospital from January 2022 to August 2022 were selected as the study subjects,
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Identification of hub genes affecting gestational diabetes mellitus based on GEO database Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-24 Yangqiu Jin, Hui Wang
ABSTRACT This research aimed to obtain gestational diabetes mellitus (GDM) related hub genes, providing new targets for clinical diagnosis and treatment of GDM. The microarray data of GSE9984 and GSE103552 were obtained from the Gene Expression Omnibus (GEO). The dataset GSE9984 contained placental gene expression profiles of 8 GDM patients and four healthy specimens. The dataset GSE103552 contained
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Causal relationships between autoimmune diseases and celiac disease: A Mendelian randomization analysis Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-23 Ting Li, Yan Feng, Chun Wang, Tian Shi, Xiaoling Huang, Mireayi Abuduhadeer, Adilai Abudurexiti, Mengxia Zhang, Feng Gao
ABSTRACT The aim of this study was to investigate the causal relationship between autoimmune disorders and celiac disease (CeD) through Mendelian randomization (MR). Single nucleotide polymorphisms (SNPs) significantly associated with 13 autoimmune diseases were extracted from the summary statistics of European genome-wide association studies (GWAS), and their effects were examined by Inverse variance-weighted
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Effect of Tiaoshen Changzhi acupuncture on behavior and striatum ΔFosB in rats with levodopa-induced dyskinesias Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-22 Yuan Li, Jiamin Zhu, Peng Sang, Yan Bai, Jinrong Lu, Hong Sun, Shun Wang
ABSTRACT This study aims to study the effffects of Tiaoshen Changzhi acupuncture on behavior and striatum ΔFosB in rats with Levodopa-induced Dyskinesias (LIDs). In this experimental study, Levodopa-induced Dyskinesia (LID) rat models were established by 6-OHDA double-target injection and randomly assigned to six groups, with ten rats in each group. The rats were subjected to difffferent interventions
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Preliminary study on the significance of pathological characteristics analysis of breast cancer and detection of peripheral blood myeloid-derived suppressor cells in the evaluation of biological characteristics Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-22 Yutong Lv, Gaoxing Wang, Ruike Gao, Guanghui Zhu, Rui Liu
ABSTRACT To explore the significance of the analysis of pathological characteristics of breast cancer and the detection of myeloid-derived suppressor cell (MDSC) levels in peripheral blood for the evaluation of biological characteristics. 138 breast cancer patients were enrolled as the research group, while 138 patients with benign breast diseases were included as the control group. All patients underwent
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Changes of peripheral blood Th cytokines in acute anterior uveitis and their relationships with recurrence Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-21 Zhipeng Wu, Xiwu Hou, Tingyu Qin
ABSTRACT Acute anterior uveitis (AAU) can cause great pain to patients. Th cytokines in peripheral blood are significantly changed in these patients, including serum interleukin-23 (IL-23), interleukin-17 (IL-17), interleukin-4 (IL-4), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) increase. However, the relationship between Th cytokines and recurrence
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Effectiveness of psychological interventions on pregnancy rates in infertile women undergoing assisted reproductive technologies: a meta-analysis of randomised controlled trials Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-18 Chaorong Bian, Jie Cao, Kejin Chen, Xiyang Xia, Xuexia Yu
ABSTRACT The purpose of this study was to assess the effects of psychological interventions on the pregnancy rates of infertile women undergoing assisted reproductive technology (ART). Using the electronic databases PubMed, EM Base, Cochrane Library, WOS, CNKI, WanFang Data, CSTJ, and CBM, a systematic literature search was conducted in the second week of August 2019. Randomized controlled trials (RCTs)
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Intraoperative blood auto-transfusion restrained the malignancy of Liver Cancer via regulating functions of tumor cells and Kuffer cells Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-18 Na Yao, Mandi Wu, Laiwei You, Jiaming Xu, Tong Liu, Jinhuo Wang, Zhenzhou Li, Jianrong Guo, Yuming Sun
ABSTRACT The role of IBA in regulating the recovery of liver cancer was investigated using a rat model of liver cancer and an intraoperative blood return model (IBA). SD rats were used to construct the IBA model. Kupffer cells were isolated from liver cancer tissues, and their biological characteristics were analyzed by flow cytometry. Comet assay was used to detect DNA damage in tumor cells; clone
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Data-based analysis of psychological and emotional changes in breast cancer patients at different ages before and after surgery Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-18 Songling Liu, Yue Wan, Xi Yu, Yalin Zhang, Lin Shen, Tianhui Su, Xiao Zou, Zheng Yan, Kaihua Zhao
ABSTRACT To analyze psychological and emotional changes in breast cancer patients at different ages before and after surgery based on data. The clinical data of 363 patients undergoing radical mastectomy for breast cancer in our hospital from December 2019 to December 2021 were selected for retrospective analysis. The patients’ psychological and emotional changes before and after surgery were evaluated
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Recent advancement in protected delivery methods for carotenoid: a smart choice in modern nutraceutical formulation concept Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-17 Surojit Bera, Ruchira Mitra, Joginder Singh
ABSTRACT Carotenoids are fat-soluble bio pigments often responsible for red, orange, pink and yellow coloration of fruits and vegetables. They are commonly referred as nutraceutical which is an alternative to pharmaceutical drugs claiming to have numerous physiological benefits. However their activity often get disoriented by photonic exposure, temperature and aeration rate thus leading to low bioavailability
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Study of ultrasound and nerve electromyogram in diagnosis of carpal tunnel syndrome and its severity in the elderly Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-17 Xin Chen, Bo Zhang, Yu Yuan
ABSTRACT Objective: To explore the diagnostic value of ultrasound and nerve electromyography (EMG) in the diagnosis of carpal tunnel syndrome (CTS) and its severity in the elderly. Methods: The data of 140 elderly CTS patients were retrospectively analyzed. The data of 80 patients with other diseases with similar symptoms and high suspicion of CTS during the same period were retrospectively analyzed
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Application of wireless ultrasound for guided caudal anesthesia in children undergoing concealed penis surgery Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-17 Yi Zhu, Ting Xiao, Shuibing Zhang, Zheng Chen, Zhen Du, Shuangquan Qu, Qian Yang
ABSTRACT Caudal anesthesia alleviates the strong pain endured by children during surgical treatment for concealed penis. In the traditional method, anesthesiologists identify the puncture point using the ‘blind probe’ method, which leads to anesthesia induction failure in children. Ultrasound has recently gained wide attention for its guidance in peripheral nerve block analgesia. However, the clinical
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The clinicopathological significance and potential function of ULK1 in colon cancer Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-16 Peng Lv, Zixi Wu, Lin Lai, Yukun Zhang, Bo Pei
ABSTRACT Uncoordinated 51-like kinase 1 (ULK1) is an essential part involved in autophagy to maintain cell viability and homeostasis. Herein, the expression levels of ULK1 in colon cancer (CC) were investigated, and its clinicopathological features and potential function were analyzed. Data of ULK1 were obtained from a public database. UCSC XENA RNAseq data were uniformly processed by using the Toil
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Antidiabetic effect of flavonoid from Rumex vesicarius on alloxan induced diabetes in Male Albino Wistar rats and its validation through in silico molecular docking and dynamic simulation studies Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-16 Abeer A. Al-Masri, Fuad Ameen, Rakesh Davella, Estari Mamidala
ABSTRACT The leaves of Rumex vescarius L. are used locally to treat diabetes, a chronic illness. A flavonoid called Luteolin from R. vesicarius was chosen to explore for the antidiabetic potential through the in vivo antidiabetic test against male albino Wistar rats that had been induced with diabetes due to alloxan. Additionally, docking screening was carried out with the aid of autodock software
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The progress on the relationship between gut microbiota and immune checkpoint blockade in tumors Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-16 Haili Jiang, Yingquan Ye, Mingqi Wang, Xin Sun, Ting Sun, Yang Chen, Ping Li, Mei Zhang, Ting Wang
ABSTRACT Immune checkpoint blockade (ICB) has emerged as a promising immunotherapeutic approach for the treatment of various tumors. However, the efficacy of this therapy is limited in a subset of patients, and it is important to develop strategies to enhance immune responses. Studies have demonstrated a critical role of gut microbiota in regulating the therapeutic response to ICB. Gut microbiota composition
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Decapping enzyme 2 is a novel immune-related biomarker that predicts poor prognosis in glioma Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-16 Yuran Mei, Qiaoli Lv, Zilong Tan, Zhe Zhang, Yulong Ji, Shuhui Chen, Xiaoli Shen
ABSTRACT This study analyzed sequencing and clinical data from the Cancer Genome Atlas (TCGA) and gene expression synthesis, and used Chinese glioma Genome Atlas (CGGA) data for external validation. The expression of DCP2 in normal brain and tumor tissue was compared. We analyzed the clinical and molecular characteristics and prognostic value of DCP2 in glioma. In addition, DCP2 expression levels were
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Deep learning-based measurement of echocardiographic data and its application in the diagnosis of sudden cardiac death Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-14 Lu Zhang, Bohan Liu, Sulei Li, Jing Wang, Yang Mu, Xuan Zhou, Li Sheng
ABSTRACT This study aimed to evaluate the potential of deep learning applied to the measurement of echocardiographic data in patients with sudden cardiac death (SCD). 320 SCD patients who met the inclusion and exclusion criteria underwent clinical evaluation, including age, sex, BMI, hypertension, diabetes, cardiac function classification, and echocardiography. The diagnostic value of deep learning
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Effects of predictive nursing combined with bird nest nursing intervention on motor function, intelligence and growth development of neonates with hypoxic-ischemic encephalopathy Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-12 Rongrong Fang, Hui Wang, Lisha Li, Weike Liu
ABSTRACT Through the analysis of the existing case data, this study explored the application effect of predictive nursing combined with bird nest nursing in children with hypoxic ischemic encephalopathy. The data of 120 children with hypoxic-ischemic encephalopathy admitted to our hospital from May 2019 to June 2021 were retrospectively analyzed, and they were divided into A (n = 40), B (n = 40) and
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Correlation between pure tone audiometry at all frequencies and distortion product otoacoustic emission of patients with hidden hearing loss Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-12 Yongqing Ding, Yachao Liu, Dong Li, Ruili Hu, Zedong Tian, Qi Xie
ABSTRACT To explore the correlation between pure tone audiometry at all frequencies and distortion product otoacoustic emission (DPOAE) of hidden hearing loss (HHL). The workers exposed to noise from a factory in Zhangjiakou (noise exposure group, n = 73) and normal young and middle-aged people recruited by society (control group, n = 77) from August 2021 to April 2022 were study subjects, and all
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Analysis on application effect and prognostic factors of medical care combined with nursing in the elderly with T2DM and Cerebral Infarction based on targeted management mode Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-12 Hongyan Qin, Haiyan Du, Haizhen Wang, Shan Li
ABSTRACT To explore the analysis on application effect and prognostic factors of medical care combined with nursing in the elderly with type 2 diabetes mellitus (T2DM) and cerebral infraction (CI) based on targeted management mode. The clinical data of 180 elderly patients with T2DM and CI in our hospital from August 2017 to August 2019 were selected for retrospective analysis. Their cognitive function
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Application effect of prehospital-hospital integrated emergency nursing in patients with acute cerebral infarction Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-09 Yujuan Chen, Ying Mao, Lihui Chen
ABSTRACT This investigation aimed to elucidate the application impact of prehospital-hospital integrated emergency nursing in individuals with acute cerebral infarction (ACI). Data of 230 ACI patients admitted to our hospital from May 2021 to July 2022 were retrospectively analyzed and divided into A and B groups (AG and BG) according to different nursing methods. The inter-group comparison of the
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Bovine pulmonary surfactant alleviates inflammation and epithelial cell apoptosis in the early phase of lipopolysaccharide-induced acute lung injury in rats Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-08 Xinxin Chen, John Sieh Dumbuya, Jiang Du, Lijun Xue, Qiyi Zeng
ABSTRACT We investigate the impact of bovine pulmonary surfactant (PS) on LPS-induced ALI in vitro and in vivo to improve recognition and prevent mortality in sepsis-induced ALI. Primary alveolar type II (AT2) cells were treated with LPS alone or in combination with PS. Cell morphology observation, CCK-8 proliferation assay, flow cytometry apoptosis assay, and ELISA for inflammatory cytokine levels
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Silencing of ALOX15 reduces ferroptosis and inflammation induced by cerebral ischemia-reperfusion by regulating PHD2/HIF2α signaling pathway Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-08 Bo Lei, Honggang Wu, Guoliang You, Xiaoqiang Wan, Shu Chen, Li Chen, Jiachuan Wu, Niandong Zheng
ABSTRACT Objective: To investigate the potential mechanism of arachidonic acid deoxyribozyme 15 (ALOX15) in ferroptosis and inflammation induced by cerebral ischemia reperfusion injury. Methods: The mice and cell models of cerebral ischemia-reperfusion injury were constructed. Western Blot was used to detect the protein expression levels of ALOX15, glutathione peroxidase (GPX4), hypoxia-inducible factor-2α
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Influencing factors of prognosis in children with pulmonary atresia with intact ventricle septum after transthoracic balloon dilation of pulmonary valve and construction of a nomograph prediction model Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-08 Mengxuan Zou, Shuo Dong, Shun Liu, Chuhao Du, Yangxue Sun, Jie Dong, Haitao Xu, Jun Yan
ABSTRACT This study aimed to identify factors that affect the prognosis of children with pulmonary valve atresia and intact ventricular septum treated with transthoracic balloon dilation of the pulmonary valve. The study included 148 participants who were followed up for 5 years. Of these, 10 died, while 138 survived. Independent sample t-test and χ2 test were used to analyze clinical data of children
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CXCR2 (rs3890158 and rs2230054) and CXCL4 (rs352008 and rs1801572) gene polymorphisms in patients with thoracic aortic aneurysm Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-08 Hua Zhao, Yanrong Xu, Jun Cui
ABSTRACT We aimed to explore the correlations of C-X-C motif chemokine receptor 2 (CXCR2) and chemokine (C-X-C motif) ligand 4 (CXCL4) gene polymorphisms with thoracic aortic aneurysm. A total of 50 patients with thoracic aortic aneurysm (disease group) and 50 healthy people in the physical examination center (control group) in our hospital were selected as the subjects. The CXCR2 and CXCL4 gene polymorphisms
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The role and mechanism of FTO in pulmonary vessels Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-08 Jing Xu, Dong Yin, Wenjing Zhang, Yi Xu
ABSTRACT Pulmonary vascular remodeling (PVR) is the main factor of pulmonary hypertension (PH). The pathological characteristics of PVR are vascular smooth muscle hyperplasia, hypertrophy, and extensive damage. In vivo experiments, the expression of FTO in PH rat lung tissues of different rat models of hypoxia PH was observed by immunohistochemical method. mRNA microarray analysis was used to analyze
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Predictive value of serum SCCA and CYFRA21-1 levels on radiotherapy efficacy and prognosis in patients with non-small cell lung cancer Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-08 Fei Chen, Xia Zhang
ABSTRACT Monitoring changes in serum tumor marker concentrations can help in the early diagnosis of non-small cell lung cancer (NSCLC). However, there are few methods to monitor the efficacy and prognosis of radiotherapy in NSCLC patients. The present research aimed to explore the correlation between radiotherapy efficacy and squamous cell carcinoma antigen (SCCA) and cytokeratin 19 soluble fragment
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Differential differentiation of B cell lymphopoiesis in lethal and non-lethal murine malaria models Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-05 Madhumita Panda, Bidyut Das, Farkad Bantun, Aditya K. Panda, Mohd Wahid, Raju K. Mandal, Naeem F. Qusty, Shafiul Haque, Balachandran Ravindran
ABSTRACT B cells in protection against malaria and need of experiencing many episodes in humans to achieve a state of immunity is largely unknown. The cellular basis of such defects in terms of B cell generation, maturation and trafficking was studied by taking Plasmodium chabaudi, a non-lethal and Plasmodium berghei, a lethal murine model. A flow cytometry (FCF) based evaluation was used to study
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Bioinformatics analysis illustrates the functions of miR-377-5p in cervical cancer Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-05 Dongjie Wang, Yifeng Zhang, Dongyan Ren, Chunmei Meng, Liufeng Yang
ABSTRACT Cervical cancer (CC) is a frequent disease in women whose development is related with miRNA disorder. MiR-377-5p plays a negative role in the development of some tumors, while few studies have revealed its role in CC. In this study, the functions of miR-377-5p in CC were investigated by bioinformatics. Briefly, the expression and survival curve of miR-377-5p in CC was analyzed with the Cancer
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Mapping themes, trends, and knowledge structure of Behcet syndrome: a bibliometric analysis from 2010 to 2021 Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-05 Haopeng Wu, Yuan Zhong, Bowen Zheng, Yi Liu
ABSTRACT This study employed bibliometric analysis to examine the current literature on Behcet Syndrome, an autoimmune disorder with complex pathophysiology and inadequate therapeutic options. The researchers collected 3,462 publications related to Behcet Syndrome from 2010 to 2021 via PubMed and conducted co-word and social network analyses to identify research hotspots and potential future directions
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Cellular therapeutic potential of genetically engineered stem cells in cancer treatment Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-03 Emina Karahmet Sher, Azra Kalić, Amina Džidić-Krivić, Merima Beća- Zećo, Emma Pinjić, Farooq Sher
ABSTRACT Traditional therapeutic approaches in the treatment of cancer have many side effects and are often ineffective and non-specific, leading to the development of therapy-resistant tumour cells. Recently, numerous discoveries about stem cells have given a new outlook on their application in oncology. Stem cells are unique because of their biological attributes, including self-renewal, differentiation
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The influence of interventional measures on metabolic factors in fluoride and aluminum combined poisoning bones Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-02 Lihua Wang, Xianghui Qin, Maojuan Yu
ABSTRACT This study aimed to evaluate the effects of soybean, selenium and spirulina on bone metabolic factors in rats with combined fluoride and aluminum poisoning.Methods:Sixty SD rats were allocated to five groups: A control group, a high-fluoride aluminum group, a high-fluoride aluminum plus soybean group, a high-fluoride aluminum plus selenium group, and a high-fluoride aluminum plus spirulina
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Correlation between coefficient of variation of blood pressure and cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-02 Xia Liu, Xuelian Zhang, Xuefen Qian, LuHang Shi, Qiaoling Liu
ABSTRACT To investigate the correlation between the coefficient of variation of blood pressure and cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease. 415 patients with hypertension complicated by cerebral small vessel disease who received treatment in our hospital from January 2019 to June 2022 were retrospectively included in this study. These patients
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The association between pruritic dermatoses and inflammatory factors on sleep disorders: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES) Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-02 Chun Ren, Dinghua Kang, Minjie Zhang
ABSTRACT Pruritic dermatoses and sleep disorders have significant impacts on the health and quality of life of patients. Inflammatory conditions may lead to the sensation of itching. This study was to evaluate the association between pruritic dermatoses and inflammatory factors on sleep disorders. Data in the cross-sectional study were extracted from the National Health and Nutrition Examination Survey
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The success rate of cardiopulmonary resuscitation and its correlated factors in patients with emergency prehospital cardiac arrest Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-02 Zongjiang Bai, Lantao Wang, Bin Yu, Dong Xing, Jie Su, Hao Qin
ABSTRACT To assess the initial success rate and its correlated factors on cardiopulmonary resuscitation (CPR) in emergency prehospital cardiac arrest patients. The clinical information of 429 patients with cardiac arrest who underwent prehospital CPR in the fourth hospital of Hebei Medical University from Jan 2020 to Apr 2022 were evaluated. The patients were divided into the successful group (ROSC
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Placenta-derived exosomes as carriers of non-coding RNAs in maternal circulation of patients with preeclampsia Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-02 Yang Yang, RuiFang An, Yufei Yuan, Youyi Chen, Jing Zhao, Xiaoming Zhu, Yuan Ma
ABSTRACT This study was conducted to illustrate the origin of these PE-related ncRNAs in maternal circulation and their underlying transport methods into target cells. We selected 10 women with severe pre-eclampsia (PE group) and 10 healthy participants who served as controls (NC group). Exosomes were isolated from their sera and their origin was determined by a specific marker, placental alkaline
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Hsa_circ_0057104, by competitive adsorption of miR-627-5p, mediates CCND2 expression to promote malignant proliferation and Warburg effect of colorectal cancer Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-05-02 Lin Zhang, Jian Xu, Dequan Jiang, Jing Zhang, Hongyuan Li, Zhengzhong Zhao, Zhechuan Mei
ABSTRACT Objective: hsa_circ_0057104 (circPDK1) has been elucidated to regulate malignant behavior in pancreatic and renal cell carcinoma. The study functionally aimed at how circPDK1 modifies colorectal cancer (CRC) progression, along with its potential molecular mechanism.Methods: circPDK1 expression patterns in CRC tissues and cell lines were analyzed by RT-qPCR. circPDK1/miR-627-5p/CCND2 expression
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CAPN1 is a novel biomaker of patients with AML based on comprehensive analysis Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-04-28 Houcai Wang, Ruye Ma, Jianbang Gu, Pan Chen, Yuwen Wang, Rong Wei
ABSTRACT Acute myeloid leukemia (AML) is a common hematologic malignancy in adults. Recent studies investigating the potential pathogenesis of AML have significantly advanced our understanding of this disease. While cytogenetics and molecular abnormalities are crucial for confirming chemotherapy response and long-term outcomes, there are additional potential therapeutic targets and prognostic factors
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Analysis of therapeutic effect of subliminal cognition combined with hypnotherapy on anxiety disorder via neural network Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-04-27 Hanyue Zhang, Xuejiao Yuan, Norhasmah Binti Mohd Zain, Ying Gao
ABSTRACT Hypnotherapy combined with cognitive therapy is an effective way to intervene anxiety problems, which also responds to the call that using hypnotherapy to treat somatic disorders should become a trend in the future. This paper constructs an evaluation index of the intervention effect of cognitive hypnotherapy on anxiety patients, and then uses neural network to evaluate its effect. At last
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Analysis of risk factors of lower extremity deep venous thrombosis in patients undergoing hepatobiliary surgery Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-04-27 Dan Song, Wenyuan Song, Peng Li, Hongyan Zhao, Xiaoting Lv
ABSTRACT This study analyzed records of 200 patients who underwent hepatobiliary surgery to identify factors that contribute to lower extremity venous thromboembolism (VTE). 19 patients (9.50%) developed lower extremity deep vein thrombosis. Univariate analysis revealed significant differences between the study group and the control group in terms of age, body mass index, previous thromboembolic history
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Evaluating the value of progressive muscle relaxation therapy for patients with lumbar disc herniation after surgery based on a difference-in-differences model Biotechnol. Genet. Eng. Rev. (IF 3.2) Pub Date : 2023-04-26 Xiaoxin Chen, Guoliang Chen, Yanhong Zhao, Qunying Chen, Junlin Huang, Guanqiong Hu
ABSTRACT We evaluate the value of progressive muscle relaxation (PMR) for patients with lumbar disc herniation after surgery based on a difference-in-differences model. A total of 128 patients with lumbar disc herniation who underwent surgery were randomly assigned to undergo either conventional intervention (conventional intervention group, n = 64) or conventional intervention combined with PMR (PMR