Graphene quantum dots (GQDs), the latest member of graphene family, have attracted outstanding interest in the last few years, due to their exceptional physical, chemical, electrical, optical and biological properties. Their strong size‐dependent photoluminescence (PL) and the presence of many reactive groups on the graphene surface allow their multimodal conjugation with therapeutic agents, targeting

Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment of haematological malignancies, with successful long‐term patient outcomes. In spite of the clinical promise however, many of the commercially‐approved or late‐stage clinical trial therapies are prohibitively expensive to manufacture. Consistent and scalable manufacturing technologies are required to

One of the trends in downstream processing comprises the use of “anything‐but‐chromatography” methods to overcome the current downfalls of standard packed‐bed chromatography. Precipitation and magnetic separation are two techniques already proven to accomplish protein purification from complex media, yet never used in synergy. With the aim to capture antibodies directly from crude extracts, a new approach

Modular co‐culture engineering is an emerging approach for biosynthesis of complex natural products. In this study, we constructed microbial co‐cultures composed of two and three E. coli strains, respectively, for de novo biosynthesis of flavonoid acacetin, a value‐added natural compound possessing numerous demonstrated biological activities, from simple carbon substrate glucose. To this end, the heterologous

Osteoarthritis (OA) is one of the most common musculoskeletal diseases, caused by cellular inflammatory responses and subsequent structural disruption in osteochondral extracellular matrix (ECM) in cartilage tissues. Various cell‐therapies have been recently developed via the exogenous administration of mesenchymal stem cells (MSCs) due to their intrinsic regenerative capacity of self‐renewal and chondrogenic

This special issue of Biotechnology Journal is devoted to the 14th Asian Congress on Biotechnology 2019 (ACB 2019) organized by the Asian Federation of Biotechnology (AFOB) and the Biotechnology and Biochemical Engineering Society of Taiwan (BEST). ACB 2019 was held in Tamsui, New Taipei City, Taiwan, in July 1–4, 2019, and involved 5 plenary lectures and 57 academic sessions in various fields of biotechnology

Certain microbial biofilm in the human‐microbiota community can negatively impact the host microbiome. This gives rise to various methods to prevent the formation of biofilms or to facilitate biofilm dispersal from surfaces and tissues in the host. Despite all these efforts, these persistent microbial biofilms on surfaces and in the host tissue can result in health problems to the host and its microbiome

Measurements of the unitary hydraulic conductivity of membrane channels, pf , may be hampered by difficulties in producing sufficient quantities of purified and reconstituted proteins. Low yield expression, the purely empiric choice of detergents, as well as protein aggregation and misfolding during reconstitution may result in an average of less than one reconstituted channel per large unilamellar

The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), previously known by the provisional name 2019 novel coronavirus (2019‐nCoV), in the city of Wuhan in China's Hubei province in 2019–2020 has been causing significant numbers of mortality and morbility in humans with the coronavirus infection diseases (COVID‐19) with fever, severe respiratory illness, and pneumonia