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YY1 Contributes to the Inflammatory Responses of Mycobacterium tuberculosis‐Infected Macrophages Through Transcription Activation-Mediated Upregulation TLR4 Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-16 Xing Yang, Yu Chen, Bingshuang Pu, Xuan Yuan, Jiaojiao Wang, Chun Chen
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Plant-Produced Therapeutic Crizanlizumab Monoclonal Antibody Binds P-Selectin to Alleviate Vaso-occlusive Pain Crises in Sickle Cell Disease Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-15 Taewon Yang, Hyunjoo Hwang, Kibum Kim, Yerin Kim, Richard D. Cummings, Yong Kyoo Shin, Taejin Lee, Kisung Ko
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Computational Analysis of Non-synonymous SNPs in ATM Kinase: Structural Insights, Functional Implications, and Inhibitor Discovery Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-15
Abstract Ataxia telangiectasia-mutated (ATM) protein kinase, a key player in cellular integrity regulation, is known for its role in DNA damage response. This study investigates the broader impact of ATM on cellular processes and potential clinical manifestations arising from mutations, aiming to expand our understanding of ATM’s diverse functions beyond conventional roles. The research employs a comprehensive
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HELLS Knockdown Inhibits the Malignant Progression of Lung Adenocarcinoma Via Blocking Akt/CREB Pathway by Downregulating KIF11 Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-13 Gang Yang, Jinsong Fu, Jiawei Wang, Mei Ding
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Identification of Key lncRNAs in Gout Under Copper Death and Iron Death Mechanisms: A Study Based on ceRNA Network Analysis and Random Forest Algorithm Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-12
Abstract This study focused on identifying potential key lncRNAs associated with gout under the mechanisms of copper death and iron death through ceRNA network analysis and Random Forest (RF) algorithm, which aimed to provide new insights into the molecular mechanisms of gout, and potential molecular targets for future therapeutic strategies of gout. Initially, we conducted an in-depth bioinformatics
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Sufentanil Suppresses Cell Carcinogenesis Via Targeting miR-186-5p/HMGB1 Axis and Wnt/β-Catenin Pathway in Non-Small-Cell Lung Cancer Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-12
Abstract Sufentanil is a common opioid anesthetic agent, which exerts anti-cancer properties in several cancer types. However, its action mechanisms in non-small cell lung cancer (NSCLC) are unclear. Therefore, the present study investigated the pharmacological effect of sufentanil on miRNAs in NSCLC treatment. In this study, after treatment with sufentanil, the proliferation, migration, invasion and
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Platelet-Derived Microvesicles Mediate Cardiomyocyte Ferroptosis by Transferring ACSL1 During Acute Myocardial Infarction Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-11 Yunfeng Zhao, Rui Cui, Ran Du, Chunmei Song, Fei Xie, Lin Ren, Junquan Li
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Mechanistic Investigation of Calcium Channel Regulation-Associated Genes in Pulmonary Arterial Hypertension and Signatures for Diagnosis Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-09 Dongjuan Chen, Jun Yang, Ting Zhang, Xuemei Li, Qiliang Xiong, Shaofeng Jiang, Chen Yi
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Abridgement of Microbial Esterases and Their Eminent Industrial Endeavors Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-09
Abstract Esterases are hydrolases that contribute to the hydrolysis of ester bonds into both water-soluble acyl esters and emulsified glycerol-esters containing short-chain acyl groups. They have garnered significant attention from biotechnologists and organic chemists due to their immense commercial value. Esterases, with their diverse and significant properties, have become highly sought after for
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FDA-Approved Chimeric Antigen Receptor (CAR)-T Cell Therapy for Different Cancers-A Recent Perspective Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-08 R. Thirumalaisamy, S. Vasuki, S. M. Sindhu, T. M. Mothilal, V. Srimathi, B. Poornima, M. Bhuvaneswari, Mohan Hariharan
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O-sialoglycoprotein Endopeptidase (OSGEP) Suppresses Hepatic Ischemia-Reperfusion Injury-Induced Ferroptosis Through Modulating the MEK/ERK Signaling Pathway Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-08 Yuanyuan Tao, Wanqing Zhou, Cheng Chen, Qian Zhang, Zhuoyi Liu, Pingping Xia, Zhi Ye, Chunling Li
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Association Between Altered Microbiota Composition and Immune System-Related Genes in COVID-19 Infection Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-08 Sara Ahmadi Badi, Arian Kariman, Ahmad Bereimipour, Shima Shojaie, Mohammadreza Aghsadeghi, Shohreh Khatami, Andrea Masotti
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An Efficient Probe-Based Quantitative PCR Assay Targeting Human-Specific DNA in ST6GALNAC3 for the Quantification of Human Cells in Preclinical Animal Models Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-08 Jinfeng Ren, Ke Liu, Lang Hu, Ruoning Yang, Yuting Liu, Siyu Wang, Xinzhu Chen, Shuli Zhao, Luyao Jing, Tiantian Liu, Bin Hu, Xuefeng Zhang, Hui Wang, Hui Li
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Lectin: A Molecular Tool in Cancer Diagnosis and Therapy with Special Reference to Reproductive Cancers Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-08 Rachna M. Pallar, Shubhangi K. Pingle, Avinash Shivaji Gaikwad, Naveen S. Yennam, N. Raju, Panja Kumar, Vinay Kumar Adepu, Rajani G. Tumane, Chennuru Veeranjaneyulu, Kartikey Matte
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ADME Study, Molecular Docking, Elucidating the Selectivities and the Mechanism of [4 + 2] Cycloaddition Reaction Between (E)-N ((dimethylamino)methylene)benzothioamide and (S)-3-acryloyl-4-phenyloxazolidin-2-one Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-08 Mhamed Atif, Ali Barhoumi, Asad Syed, Ali H. Bahkali, Mohammed Chafi, Abdessamad Tounsi, Abdellah Zeroual, Bilal Ahamad Paray, Shifa Wang, Mohammed El Idrissi
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The Interplay Between Epilepsy and Parkinson’s Disease: Gene Expression Profiling and Functional Analysis Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-07 Xiaolong Wu, Kailiang Wang, Jingjing Wang, Penghu Wei, Huaqiang Zhang, Yanfeng Yang, Yinchun Huang, Yihe Wang, Wenli Shi, Yongzhi Shan, Guoguang Zhao
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The Up-Regulated Expression of Mitochondrial Membrane Molecule RHOT1 in Gastric Cancer Predicts the Prognosis of Patients and Promotes the Malignant Biological Behavior of Cells Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-06 Fanhao Kong, Siwen Yang, Ruimeng Shi, Yanyu Peng
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Heterologous Expression of Phycocyanobilin in Escherichia coli and Determination of Its Antioxidant Capacity In Vitro Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-05 Ziying Ye, Jun Fang, Bin Yao, Gang Liu
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Circ_0082374 Promotes the Tumorigenesis and Suppresses Ferroptosis in Non-small Cell Lung Cancer by Up-Regulating GPX4 Through Sequestering miR-491-5p Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-04 Zongyu Li, Mengdi Fan, Zhibo Zhou, Xianyin Sang
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YB-1 Targeted by miR-509-3-5p Affects Migration and Invasion of Triple‑Negative Breast Cancer by Regulating Cellular Epithelial‑Mesenchymal Transition Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-04 Hanzhi Dong, Zhiqiang Peng, Tenghua Yu, Jianping Xiong
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DNA Barcoding of Invasive Terrestrial Plant Species in India Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-02 Nayan Lonare, Gayatri Patil, Suprriya Waghmare, Reshma Bhor, Hrishikesh Hardikar, Sanket Tembe
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Long Noncoding RNA GAS5-Involved Progression of Neonatal Hydrocephalus and Inflammatory Responses Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-01 Bin Zou, Qin Zhang, Hui Gan, Yue Qin, Yudong Zhou, Xuan Zhai, Ping Liang
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Silencing circLDLRAD3 Inhibits Lung Cancer Progression by Regulating the miR-497-5p/PFKP Axis Mol. Biotechnol. (IF 2.6) Pub Date : 2024-03-01
Abstract Purpose Lung cancer is one of the leading causes of death worldwide. Recent studies have shown that circular RNAs are dysregulated in a variety of cancers, but the mechanism in lung cancer is still indistinct. In our work, we explored the action mechanism of circLDLRAD3 in lung cancer. Methods The abundance of circLDLRAD3, microRNA-497-5p (miR-497-5p) and platelet-type PFK (PFKP) was measured
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Comprehensive Analysis of circRNA, lncRNA, miRNA and mRNA Expression Profiles and Their Competing Endogenous RNA Networks in Hepatitis B Virus-Related Hepatocellular Carcinoma Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-27 Shaoying Yan, Peng Fu, Huiming Li, Zikun Huang, Renfeng Shan, Binbin Gong
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Messenger RNA Surveillance: Current Understanding, Regulatory Mechanisms, and Future Implications Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-27 Rutupurna Das, Gagan Kumar Panigrahi
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miR-324-3p Suppresses Hepatic Stellate Cell Activation and Hepatic Fibrosis Via Regulating SMAD4 Signaling Pathway Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-26 Si-Yu Chen, Xin Chen, Sai Zhu, Jin-Jin Xu, Xiao-Feng Li, Na-Na Yin, Yan-Yan Xiao, Cheng Huang, Jun Li
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LncRNA DGUOK-AS1 Promotes Cell Progression in Lung Squamous Cell Carcinoma by Regulation of miR-653-5p/SLC6A15 Axis Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-26 Yan Teng, Shixia Li, Lijuan Wei, Chi Zhang, Lijuan Li, Shuang Wang, Jing Zhang, Jinchao Huang, Huan Zhang, Nan Wu, Juntian Liu
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Effect of Different Karyophilic Peptides on Physical Characteristics and In Vitro Transfection Efficiency of Chitosan-Plasmid Nanoparticles as Nonviral Gene Delivery Systems Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-24 María Eugenia Aranda-Barradas, Héctor Eduardo Coronado-Contreras, Yareli Lizbeth Aguilar-Castañeda, Karen Donají Olivo-Escalante, Francisco Rodolfo González-Díaz, Carlos Gerardo García-Tovar, Samuel Álvarez-Almazán, Susana Patricia Miranda-Castro, Alicia Del Real-López, Abraham Méndez-Albores
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Structural and Functional Characterization of Obesumbacterium proteus Phytase: A Comprehensive In-Silico Study Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-23 Asmita Kamble, Rajkumar Singh, Harinder Singh
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Recent Advances in the Role of Different Nanoparticles in the Various Biosensors for the Detection of the Chikungunya Virus Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-23 Seyed Abbas Shahrtash, Zahraa Sabah Ghnim, Mohammad Ghaheri, Javid Adabi, Mohammad amir Hassanzadeh, Saman Yasamineh, Hamed Afkhami, Amir Hossein Kheirkhah, Omid Gholizadeh, Hesam Zendehdel Moghadam
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Hyperbaric Oxygen Upregulates Mst1 to Activate Keap1/Nrf2/HO-1 Pathway Resisting Oxidative Stress in a Rat Model of Acute Myocardial Infarction Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-23 Jianhui Liu, Yan Li, Shubiao Wu, Zhigang Zhang, Di Li
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MicroRNAs Associated with Keloids Identified by Microarray Analysis and In Vitro Experiments Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-23
Abstract MicroRNAs (miRNAs) play a crucial role in gene regulation and the development of keloid. This research aimed to identify and verify miRNAs associated with keloids by microarray analysis and in vitro experiments, shedding light on seeking for potential therapeutic molecular targets. In this study, the weighted gene co-expression network analysis was performed based on the GSE113620. The key
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Circ_0007351 Exerts an Oncogenic Role In Colorectal Cancer Depending on the Modulation of the miR-5195-3p/GPRC5A Cascade Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-22 Aijun He, Fangxin Liao, Xiaohui Lin
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Transcription Factor STAT3-Activated LDHB Promotes Tumor Properties of Endometrial Cancer Cells by Inducing MDH2 Expression Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-21 Li Shen, Juan Wang, Yanxia Li, Cuizhen Sun, Minjie Teng, Xiaohe Ye, Xiaomin Feng
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Construction of an Anoikis-Related Gene Prognostic Signature and Identification of ANGPTL4 as a Key Oncogene in Lung Adenocarcinoma Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-21 Hao Lou, Xuelian Lin, Guangyou Wei, Zelai Wu, Youde Xiao
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Genome-Wide Characterization of Differentially Expressed Scent Genes in the MEP Control Network of the Flower of Lilium ‘Sorbonne’ Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-20 Lei Cao, Fan Jiang, Dongying Liu, Jiaohua Zhang, Tao Yang, Jinzhu Zhang, Daidi Che, Jinping Fan
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Molecular Mutations in Histiocytosis: A Comprehensive Survey of Genetic Alterations Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-20
Abstract Histiocytosis represents a group of uncommon disorders characterized by the abnormal accumulation of specialized immune cells, such as macrophages, dendritic cells, or monocyte-derived cells, in various tissues and organs. Over 100 distinct subtypes have been documented, each displaying a broad spectrum of clinical presentations and histological characteristics. Till today, histiocytosis has
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Unraveling Bacterial Single-Stranded Sequence Specificities: Insights from Molecular Dynamics and MMPBSA Analysis of Oligonucleotide Probes Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-19 Teerapong Pirojsirikul, Vannajan Sanghiran Lee, Piyarat Nimmanpipug
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CircSCMH1 Accelerates Sorafenib Resistance in Hepatocellular Carcinoma by Regulating HN1 Expression via miR-485-5p Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-19
Abstract Sorafenib (SOR) is the first-line chemotherapeutic therapy for hepatocellular carcinoma (HCC) treatment, but SOR resistance is a key factor affecting the therapeutic effect. Emerging studies have suggested that circular RNAs (circRNAs) play an important role in the development of drug resistance in HCC cells. This paper aimed to elucidate the potential role and molecular mechanism of circRNA
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Engineering Camelina sativa Seeds as a Green Bioreactor for the Production of Affordable Human Pro-insulin that Demonstrates Anti-diabetic Efficacy in Rats Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-18
Abstract The current production of recombinant insulin via fermenter-based platforms (Escherichia coli and yeast) could not fulfill its fast-growing commercial demands, thus leading to a great interest in its sustainable large-scale production at low cost using a plant-based system. In the present study, Agrobacterium tumefaciens-mediated nuclear stable genetic transformation of an industrial oilseed
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Host Response of Arabidopsis thaliana Interaction with Fungal Endophytes Involves microRNAs Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-17
Abstract Plant and fungus interaction is a complex process involving many molecular factors determining the nature of relationship. The enigmatic methodology by which fungal endophytes are able to colonise a plant harmoniously is still inexplicable. Small RNAs have been identified as major regulatory elements under various biotic interactions. However, their role in endophytic plant–fungal interactions
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From Efficiency to Yield: Exploring Recent Advances in CHO Cell Line Development for Monoclonal Antibodies Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-16 Sarmishta Majumdar, Ranjeet Desai, Aakarsh Hans, Prajakta Dandekar, Ratnesh Jain
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The Future of Gene Therapy: A Review of In Vivo and Ex Vivo Delivery Methods for Genome Editing-Based Therapies Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-16 Olga Volodina, Svetlana Smirnikhina
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Development of Polyclonal Antibodies-Based Serological Method for the Detection of Calanthe Mild Mosaic Virus and Application in Virus Certification Programme Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-16 Nishant Srivastava, Rakesh Kumar, Reetika Kapoor, Ashwini Kumar, Susheel K. Sharma, Nitika Gupta, Pooja Bhardwaj, Gopi Kishan, Rajendra P. Pant, Virendra K. Baranwal
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Expression of VEGFR2 Ligand Binding Domain in Pichia pink™ 4 Cells and Evaluation of Its Interactions with VEGF-A165 Receptor Binding Domain Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-13
Abstract Vascular endothelial growth factor A165 (VEGF-A165) and VEGF receptor 2 (KDR) are important mediators of angiogenesis. We aimed to express the soluble KDR ligand-binding domain (sKDR1-3) and evaluate its interaction with the VEGF-A165 receptor-binding domain (VEGFA165-RBD). sKDR1-3 DNA was designed and subcloned into pPinkα-HC plasmid. The cassette was transfected into the Pichia pink™ 4 genome
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An Analysis Regarding the Association Between DAZ Interacting Zinc Finger Protein 1 (DZIP1) and Colorectal Cancer (CRC) Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-09 Yu Zhang, Yuan-jie Liu, Jia Mei, Zhao-xu Yang, Xiao-ping Qian, Wei Huang
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Integrin β4 Regulates Cell Migration of Lung Adenocarcinoma Through FAK Signaling Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-08 Shusen Zhang, Chengyu Liu, Dengxiang Liu, Xuecong Ning, Hui Li, Xiaochong Zhang, Yuanyuan Lu, Ping Zhang, Shubo Chen, Zhigang Cai
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Endoplasmic Reticulum Stress Promotes Neuronal Damage in Neonatal Hypoxic-Ischemic Brain Damage by Inducing Ferroptosis Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-08 Yongjia Ji, Huili Liu, Fang Niu, Bo Kang, Xiu Luo, Hua Yang, Zhen Tian, Juan Yang
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Revolutionizing Synthetic Antibody Design: Harnessing Artificial Intelligence and Deep Sequencing Big Data for Unprecedented Advances Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-03 Eugenio Gallo
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Differential Expression of Nuclear-Encoded Mitochondrial Protein Genes of ATP Synthase Across Different Tissues of Female Buffalo Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-02
Abstract The physiological well-being of buffaloes, encompassing phenotypic traits, reproductive health, and productivity, depends on their energy status. Mitochondria, the architects of energy production, orchestrate a nuanced interplay between nuclear and mitochondrial domains. Oxidative phosphorylation complexes and associated proteins wield significant influence over metabolic functions, energy
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The Application of Aptamer and Research Progress in Liver Disease Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-02 Cheng Xu, Yong Tan, Li-Ye Zhang, Xiao-Jie Luo, Jiang-Feng Wu, Lan Ma, Fei Deng
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Lipopolysaccharide-Educated Cancer-Associated Fibroblasts Facilitate Malignant Progression of Ovarian Cancer Cells via the NF-kB/IL-6/JAK2 Signal Transduction Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-02 Dongjie Wang, Lingchuan Li, Yifeng Zhang, Kefan Ye
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Unlocking Nature’s Potential: A Comparative Study of Bioactive Compounds Extracted from Tropical Microalgae Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-01 Eko Susanto, Rabbani Mahir Mustajab, Mustofa Kamil, Mochammad Fitri Atho’illah, Putut Har Riyadi, Retno Ayu Kurniasih, Ratih Pangestuti, Dwi Yanuar Budi Prasetyo
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Molecular Analysis of Pseudomonas aeruginosa Isolates with Mutant gyrA Gene and Development of a New Ciprofloxacin Derivative for Antimicrobial Therapy Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-01 Yasir Adil Jabbar Alabdali, Dhay Ali Azeez, Murad G. Munahi, Zainab I. Kuwait
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shRNA Targeting Lentiviral Vector Minus-Strand Product Improves the Viral Titer During Viral Packaging Mol. Biotechnol. (IF 2.6) Pub Date : 2024-02-01 Jiahui Wu, Wenchen Shen, Qianhai Fan, Jingzhi Zhang, Fanyi Zeng
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Structural and Functional Analysis of Groundnut bud necrosis virus (GBNV) Using Computational and Biochemical Approaches Mol. Biotechnol. (IF 2.6) Pub Date : 2024-01-30 Rohit Jamwal, Pukhrambam Pushpa Devi, Vaishali Rani, Nitish Rawat, Guisuibou Daimei, Gunjan Kumar Saurav, Perumal Renukadevi, Karuna Yadav, Anjali, Raman Rajagopal
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O‐GlcNAcylation of CSNK2A1 by OGT is Involved in the Progression of Colorectal Cancer Mol. Biotechnol. (IF 2.6) Pub Date : 2024-01-30 Zhengyao Yu, Huijuan He, Baoying Jiang, Jing Hu
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Mycoremediation of Industrial Textile Wastewater Using Ganoderma lucidum Pellets and Activated Dolomite in Batch Bioreactor Mol. Biotechnol. (IF 2.6) Pub Date : 2024-01-29 Afnan Ahmadi Zahuri, Wan Hanna Melini Wan Mohtar, Zarimah Mohd Hanafiah, Muhamad Fazly Abdul Patah, Pau-Loke Show, Yusufjon Gafforov, Wan Abd Al Qadr Imad Wan-Mohtar
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Investigation of Circular RNA Expression Profiles in Ultrasound-guided Incomplete Radiofrequency Ablation Transplanted Tumor Models of Human Liver Cancer Mol. Biotechnol. (IF 2.6) Pub Date : 2024-01-28 Dongyue Wen, Jiamin Chen, Peng Lin, Jinshu Pang, Yuyan Pang, Gang Chen, Yun He, Hong Yang
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LncRNA MIR100HG Promotes Cell Proliferation in Nasopharyngeal Carcinoma by Targeting miR-136-5p/IL-6 Axis Mol. Biotechnol. (IF 2.6) Pub Date : 2024-01-26 Xiaoyan Huang, Huaping Zhong, Yunxiang Cai