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  • Point-of-Care Devices to Detect Zika and Other Emerging Viruses.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Helena de Puig,Irene Bosch,James J Collins,Lee Gehrke

    Rapid diagnostic tests (point-of-care devices) are critical components of informed patient care and public health monitoring (surveillance applications). We propose that among the many rapid diagnostics platforms that have been tested or are in development, lateral flow immunoassays and synthetic biology–based diagnostics (including CRISPR-based diagnostics) represent the best overall options given

    更新日期:2020-06-05
  • Integrated Biophysical Modeling and Image Analysis: Application to Neuro-Oncology.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Andreas Mang,Spyridon Bakas,Shashank Subramanian,Christos Davatzikos,George Biros

    Central nervous system (CNS) tumors come with vastly heterogeneous histologic, molecular, and radiographic landscapes, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics have shown promise in better characterizing the molecular, spatial, and temporal heterogeneity of tumors. Integrative analysis of CNS tumors, including clinically

    更新日期:2020-06-05
  • Micromechanobiology: Focusing on the Cardiac Cell-Substrate Interface.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Erica A Castillo,Kerry V Lane,Beth L Pruitt

    Engineered, in vitro cardiac cell and tissue systems provide test beds for the study of cardiac development, cellular disease processes, and drug responses in a dish. Much effort has focused on improving the structure and function of engineered cardiomyocytes and heart tissues. However, these parameters depend critically on signaling through the cellular microenvironment in terms of ligand composition

    更新日期:2020-06-05
  • Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Vitaliy L Rayz,Aaron A Cohen-Gadol

    In the last two decades, numerous studies have conducted patient-specific computations of blood flow dynamics in cerebral aneurysms and reported correlations between various hemodynamic metrics and aneurysmal disease progression or treatment outcomes. Nevertheless, intra-aneurysmal flow analysis has not been adopted in current clinical practice, and hemodynamic factors usually are not considered in

    更新日期:2020-06-05
  • Engineering Approaches for Addressing Opioid Use Disorder in the Community.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Paul M Griffin

    Many communities in the United States are struggling to deal with the negative consequences of illicit opioid use. Effectively addressing this epidemic requires the coordination and support of community stakeholders in a change process with common goals and objectives, continuous engagement with individuals with opioid use disorder (OUD) through their treatment and recovery journeys, application of

    更新日期:2020-06-05
  • Physiological Modeling and Simulation-Validation, Credibility, and Application.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    W Andrew Pruett,John S Clemmer,Robert L Hester

    In this review, we discuss the science of model validation as it applies to physiological modeling. There is widespread disagreement and ambiguity about what constitutes model validity. In areas in which models affect real-world decision-making, including within the clinic, in regulatory science, or in the design and engineering of novel therapeutics, this question is of critical importance. Without

    更新日期:2020-06-05
  • Three-Dimensional Single-Molecule Localization Microscopy in Whole-Cell and Tissue Specimens.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Sheng Liu,Hyun Huh,Sang-Hyuk Lee,Fang Huang

    Super-resolution microscopy techniques are versatile and powerful tools for visualizing organelle structures, interactions, and protein functions in biomedical research. However, whole-cell and tissue specimens challenge the achievable resolution and depth of nanoscopy methods. We focus on three-dimensional single-molecule localization microscopy and review some of the major roadblocks and developing

    更新日期:2020-06-05
  • Sparse Data-Driven Learning for Effective and Efficient Biomedical Image Segmentation.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    John A Onofrey,Lawrence H Staib,Xiaojie Huang,Fan Zhang,Xenophon Papademetris,Dimitris Metaxas,Daniel Rueckert,James S Duncan

    Sparsity is a powerful concept to exploit for high-dimensional machine learning and associated representational and computational efficiency. Sparsity is well suited for medical image segmentation. We present a selection of techniques that incorporate sparsity, including strategies based on dictionary learning and deep learning, that are aimed at medical image segmentation and related quantification

    更新日期:2020-06-05
  • 4D Flow with MRI.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Gilles Soulat,Patrick McCarthy,Michael Markl

    Magnetic resonance imaging (MRI) has become an important tool for the clinical evaluation of patients with cardiac and vascular diseases. Since its introduction in the late 1980s, quantitative flow imaging with MRI has become a routine part of standard-of-care cardiothoracic and vascular MRI for the assessment of pathological changes in blood flow in patients with cardiovascular disease. More recently

    更新日期:2020-06-05
  • Transgenic and Diet-Enhanced Silk Production for Reinforced Biomaterials: A Metamaterial Perspective.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Jung Woo Leem,Malcolm J Fraser,Young L Kim

    Silk fibers, which are protein-based biopolymers produced by spiders and silkworms, are fascinating biomaterials that have been extensively studied for numerous biomedical applications. Silk fibers often have remarkable physical and biological properties that typical synthetic materials do not exhibit. These attributes have prompted a wide variety of silk research, including genetic engineering, biotechnological

    更新日期:2020-06-05
  • The New Age of Cell-Free Biology.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Vincent Noireaux,Allen P Liu

    The cell-free molecular synthesis of biochemical systems is a rapidly growing field of research. Advances in the Human Genome Project, DNA synthesis, and other technologies have allowed the in vitro construction of biochemical systems, termed cell-free biology, to emerge as an exciting domain of bioengineering. Cell-free biology ranges from the molecular to the cell-population scales, using an ever-expanding

    更新日期:2020-06-05
  • Mitigating the Consequences of Subconcussive Head Injuries.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Eric A Nauman,Thomas M Talavage,Paul S Auerbach

    Subconcussive head injury represents a pathophysiology that spans the expertise of both clinical neurology and biomechanical engineering. From both viewpoints, the terms injury and damage, presented without qualifiers, are synonymously taken to mean a tissue alteration that may be recoverable. For clinicians, concussion is evolving from a purely clinical diagnosis to one that requires objective measurement

    更新日期:2020-06-05
  • Elastin-Like Polypeptides for Biomedical Applications.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Anastasia K Varanko,Jonathan C Su,Ashutosh Chilkoti

    Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties—including lower critical solution temperature phase behavior and minimal immunogenicity—make them attractive materials for a variety of biomedical applications. ELPs also benefit from recombinant synthesis and genetically encoded design; these enable control over the molecular weight

    更新日期:2020-06-05
  • Computer-Aided Design of Microfluidic Circuits.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Elishai Ezra Tsur

    Microfluidic devices developed over the past decade feature greater intricacy, increased performance requirements, new materials, and innovative fabrication methods. Consequentially, new algorithmic and design approaches have been developed to introduce optimization and computer-aided design to microfluidic circuits: from conceptualization to specification, synthesis, realization, and refinement. The

    更新日期:2020-06-05
  • Swine Disease Models for Optimal Vascular Engineering.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Michael Sturek,Mouhamad Alloosh,Frank W Sellke

    Swine disease models are essential for mimicry of human metabolic and vascular pathophysiology, thereby enabling high-fidelity translation to human medicine. The worldwide epidemic of obesity, metabolic disease, and diabetes has prompted the focus on these diseases in this review. We highlight the remarkable similarity between Ossabaw miniature swine and humans with metabolic syndrome and atherosclerosis

    更新日期:2020-06-05
  • Layer-by-Layer Biomaterials for Drug Delivery.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Dahlia Alkekhia,Paula T Hammond,Anita Shukla

    Controlled drug delivery formulations have revolutionized treatments for a range of health conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as one of the most versatile fabrication methods used to develop multifunctional controlled drug release coatings. The numerous advantages of LbL include its ability to incorporate and preserve biological activity of therapeutic

    更新日期:2020-06-05
  • Human Positron Emission Tomography Neuroimaging.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Jacob M Hooker,Richard E Carson

    Neuroimaging with positron emission tomography (PET) is the most powerful tool for understanding pharmacology, neurochemistry, and pathology in the living human brain. This technology combines high-resolution scanners to measure radioactivity throughout the human body with specific, targeted radioactive molecules, which allow measurements of a myriad of biological processes in vivo. While PET brain

    更新日期:2020-04-21
  • Intracranial Pressure and Intracranial Elastance Monitoring in Neurocritical Care.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Thomas Heldt,Tommaso Zoerle,Daniel Teichmann,Nino Stocchetti

    Patients with acute brain injuries tend to be physiologically unstable and at risk of rapid and potentially life-threatening decompensation due to shifts in intracranial compartment volumes and consequent intracranial hypertension. Invasive intracranial pressure (ICP) monitoring therefore remains a cornerstone of modern neurocritical care, despite the attendant risks of infection and damage to brain

    更新日期:2020-04-21
  • The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Caroline A Murphy,Atul K Garg,Joana Silva-Correia,Rui L Reis,Joaquim M Oliveira,Maurice N Collins

    The treatment of meniscus injuries has recently been facing a paradigm shift toward the field of tissue engineering, with the aim of regenerating damaged and diseased menisci as opposed to current treatment techniques. This review focuses on the structure and mechanics associated with the meniscus. The meniscus is defined in terms of its biological structure and composition. Biomechanics of the meniscus

    更新日期:2020-04-21
  • Controlling Matter at the Molecular Scale with DNA Circuits.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Dominic Scalise,Rebecca Schulman

    In recent years, a diverse set of mechanisms have been developed that allow DNA strands with specific sequences to sense information in their environment and to control material assembly, disassembly, and reconfiguration. These sequences could serve as the inputs and outputs for DNA computing circuits, enabling DNA circuits to act as chemical information processors to program complex behavior in chemical

    更新日期:2020-04-21
  • The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Melanie Maurer,Jan Lammerding

    Cellular behavior is continuously affected by microenvironmental forces through the process of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical responses. Mounting evidence suggests that the nucleus itself is a mechanoresponsive element, reacting to cytoskeletal forces and mediating downstream biochemical responses. The nucleus responds through a host of mechanisms

    更新日期:2020-04-21
  • A Contemporary Look at Biomechanical Models of Myocardium.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Reza Avazmohammadi,João S Soares,David S Li,Samarth S Raut,Robert C Gorman,Michael S Sacks

    Understanding and predicting the mechanical behavior of myocardium under healthy and pathophysiological conditions are vital to developing novel cardiac therapies and promoting personalized interventions. Within the past 30 years, various constitutive models have been proposed for the passive mechanical behavior of myocardium. These models cover a broad range of mathematical forms, microstructural

    更新日期:2020-04-21
  • Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Jana Ognjenović,Reinhard Grisshammer,Sriram Subramaniam

    In recent years, cryo electron microscopy (cryo-EM) technology has been transformed with the development of better instrumentation, direct electron detectors, improved methods for specimen preparation, and improved software for data analysis. Analyses using single-particle cryo-EM methods have enabled determination of structures of proteins with sizes smaller than 100 kDa and resolutions of ∼2 Å in

    更新日期:2020-04-21
  • Single-Cell Omics Analyses Enabled by Microchip Technologies.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Yanxiang Deng,Amanda Finck,Rong Fan

    Single-cell omics studies provide unique information regarding cellular heterogeneity at various levels of the molecular biology central dogma. This knowledge facilitates a deeper understanding of how underlying molecular and architectural changes alter cell behavior, development, and disease processes. The emerging microchip-based tools for single-cell omics analysis are enabling the evaluation of

    更新日期:2020-04-21
  • Digital Manufacturing for Microfluidics.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Arman Naderi,Nirveek Bhattacharjee,Albert Folch

    The microfluidics field is at a critical crossroads. The vast majority of microfluidic devices are presently manufactured using micromolding processes that work very well for a reduced set of biocompatible materials, but the time, cost, and design constraints of micromolding hinder the commercialization of many devices. As a result, the dissemination of microfluidic technology-and its impact on society-is

    更新日期:2020-04-21
  • Skin-Mountable Biosensors and Therapeutics: A Review.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Eun Kwang Lee,Min Ku Kim,Chi Hwan Lee

    Miniaturization of electronic components and advances in flexible and stretchable materials have stimulated the development of wearable health care systems that can reflect and monitor personal health status by health care professionals. New skin-mountable devices that offer seamless contact onto the human skin, even under large deformations by natural motions of the wearer, provide a route for both

    更新日期:2020-04-21
  • Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Nikhil Jain,Jens Moeller,Viola Vogel

    In addition to their early-recognized functions in host defense and the clearance of apoptotic cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If misregulated, they steer the progression of many inflammatory diseases. Much progress has been made in understanding the mechanisms underlying macrophage signaling, transcriptomics, and proteomics, under physiological

    更新日期:2020-04-21
  • Programming Stimuli-Responsive Behavior into Biomaterials.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Barry A Badeau,Cole A DeForest

    Stimuli-responsive materials undergo triggered changes when presented with specific environmental cues. These dynamic systems can leverage biological signals found locally within the body as well as exogenous cues administered with spatiotemporal control, providing powerful opportunities in next-generation diagnostics and personalized medicine. Here, we review the synthetic and strategic advances used

    更新日期:2020-04-21
  • Challenges and Opportunities in the Design of Liver-on-Chip Microdevices.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Avner Ehrlich,Daniel Duche,Gladys Ouedraogo,Yaakov Nahmias

    The liver is the central hub of xenobiotic metabolism and consequently the organ most prone to cosmetic- and drug-induced toxicity. Failure to detect liver toxicity or to assess compound clearance during product development is a major cause of postmarketing product withdrawal, with disastrous clinical and financial consequences. While small animals are still the preferred model in drug development

    更新日期:2020-04-21
  • Frontiers of Medical Robotics: From Concept to Systems to Clinical Translation.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Jocelyne Troccaz,Giulio Dagnino,Guang-Zhong Yang

    Medical robotics is poised to transform all aspects of medicine-from surgical intervention to targeted therapy, rehabilitation, and hospital automation. A key area is the development of robots for minimally invasive interventions. This review provides a detailed analysis of the evolution of interventional robots and discusses how the integration of imaging, sensing, and robotics can influence the patient

    更新日期:2020-04-21
  • Biomaterials: Been There, Done That, and Evolving into the Future.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Buddy D Ratner

    Biomaterials as we know them today had their origins in the late 1940s with off-the-shelf commercial polymers and metals. The evolution of materials for medical applications from these simple origins has been rapid and impactful. This review relates some of the early history; addresses concerns after two decades of development in the twenty-first century; and discusses how advanced technologies in

    更新日期:2020-04-21
  • Hydrogel-Based Strategies to Advance Therapies for Chronic Skin Wounds.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Lucília P da Silva,Rui L Reis,Vitor M Correlo,Alexandra P Marques

    Chronic skin wounds are the leading cause of nontraumatic foot amputations worldwide and present a significant risk of morbidity and mortality due to the lack of efficient therapies. The intrinsic characteristics of hydrogels allow them to benefit cutaneous healing essentially by supporting a moist environment. This property has long been explored in wound management to aid in autolytic debridement

    更新日期:2020-04-21
  • New Sensor and Wearable Technologies to Aid in the Diagnosis and Treatment Monitoring of Parkinson's Disease.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Mariana H G Monje,Guglielmo Foffani,José Obeso,Álvaro Sánchez-Ferro

    Parkinson's disease (PD) is a degenerative disorder of the brain characterized by the impairment of the nigrostriatal system. This impairment leads to specific motor manifestations (i.e., bradykinesia, tremor, and rigidity) that are assessed through clinical examination, scales, and patient-reported outcomes. New sensor-based and wearable technologies are progressively revolutionizing PD care by objectively

    更新日期:2020-04-21
  • The Biocompatibility Challenges in the Total Artificial Heart Evolution.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Eleonora Dal Sasso,Andrea Bagno,Silvia T G Scuri,Gino Gerosa,Laura Iop

    There are limited therapeutic options for final treatment of end-stage heart failure. Among them, implantation of a total artificial heart (TAH) is an acceptable strategy when suitable donors are not available. TAH development began in the 1930s, followed by a dramatic evolution of the actuation mechanisms operating the mechanical pumps. Nevertheless, the performance of TAHs has not yet been optimized

    更新日期:2020-04-21
  • Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Kinam Park,Andrew Otte

    Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent technologies to combat the current opioid epidemic. These abuse-deterrent formulations (ADFs) are intended to deter physical and chemical tampering of opioid-based products, while still providing safe and effective delivery for therapeutic purposes

    更新日期:2020-04-21
  • Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Marc A Simon,Timothy N Bachman,John Watson,J Timothy Baldwin,William R Wagner,Harvey S Borovetz

    Our review in the 2008 volume of this journal detailed the use of mechanical circulatory support (MCS) for treatment of heart failure (HF). MCS initially utilized bladder-based blood pumps generating pulsatile flow; these pulsatile flow pumps have been supplanted by rotary blood pumps, in which cardiac support is generated via the high-speed rotation of computationally designed blading. Different rotary

    更新日期:2020-04-21
  • Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Lindong Weng,Shannon L Stott,Mehmet Toner

    Successful stabilization and preservation of biological materials often utilize low temperatures and dehydration to arrest molecular motion. Cryoprotectants are routinely employed to help the biological entities survive the physicochemical and mechanical stresses induced by cold or dryness. Molecular interactions between biomolecules, cryoprotectants, and water fundamentally determine the outcomes

    更新日期:2020-04-21
  • Targeted and Nontargeted α-Particle Therapies.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Michael R McDevitt,George Sgouros,Stavroula Sofou

    α-Particle irradiation of cancerous tissue is increasingly recognized as a potent therapeutic option. We briefly review the physics, radiobiology, and dosimetry of α-particle emitters, as well as the distinguishing features that make them unique for radiopharmaceutical therapy. We also review the emerging clinical role of α-particle therapy in managing cancer and recent studies on in vitro and preclinical

    更新日期:2018-06-04
  • Synthetic Biology: Immunotherapy by Design
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Matthew J. Brenner, Jang Hwan Cho, Nicole M.L. Wong, Wilson W. Wong

    Cellular immunotherapy holds great promise for the treatment of human disease. Clinical evidence suggests that T cell immunotherapies have the potential to combat cancers that evade traditional immunotherapy. Despite promising results, adverse effects leading to fatalities have left scientists seeking tighter control over these therapies, which is reflected in the growing body of synthetic biology

    更新日期:2018-06-04
  • Bone Mechanical Properties in Healthy and Diseased States
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Elise F. Morgan, Ginu U. Unnikrisnan, Amira I. Hussein

    The mechanical properties of bone are fundamental to the ability of our skeletons to support movement and to provide protection to our vital organs. As such, deterioration in mechanical behavior with aging and/or diseases such as osteoporosis and diabetes can have profound consequences for individuals’ quality of life. This article reviews current knowledge of the basic mechanical behavior of bone

    更新日期:2018-06-04
  • Facet Joints of the Spine: Structure–Function Relationships, Problems and Treatments, and the Potential for Regeneration
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Siobhan A. O'Leary, Nikolaos K. Paschos, Jarrett M. Link, Eric O. Klineberg, Jerry C. Hu, Kyriacos A. Athanasiou

    The zygapophysial joint, a diarthrodial joint commonly referred to as the facet joint, plays a pivotal role in back pain, a condition that has been a leading cause of global disability since 1990. Along with the intervertebral disc, the facet joint supports spinal motion and aids in spinal stability. Highly susceptible to early development of osteoarthritis, the facet is responsible for a significant

    更新日期:2018-06-04
  • Electrophysiological Source Imaging: A Noninvasive Window to Brain Dynamics
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Bin He, Abbas Sohrabpour, Emery Brown, Zhongming Liu

    Brain activity and connectivity are distributed in the three-dimensional space and evolve in time. It is important to image brain dynamics with high spatial and temporal resolution. Electroencephalography (EEG) and magnetoencephalography (MEG) are noninvasive measurements associated with complex neural activations and interactions that encode brain functions. Electrophysiological source imaging estimates

    更新日期:2018-06-04
  • Engineering the Mucus Barrier
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    T.L. Carlson, J.Y. Lock, R.L. Carrier

    Mucus selectively controls the transport of molecules, particulate matter, and microorganisms to the underlying epithelial layer. It may be desirable to weaken the mucus barrier to enable effective delivery of drug carriers. Alternatively, the mucus barrier can be strengthened to prevent epithelial interaction with pathogenic microbes or other exogenous materials. The dynamic mucus layer can undergo

    更新日期:2018-06-04
  • Advanced Endoscopic Navigation: Surgical Big Data, Methodology, and Applications
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Xiongbiao Luo, Kensaku Mori, Terry M. Peters

    Interventional endoscopy (e.g., bronchoscopy, colonoscopy, laparoscopy, cystoscopy) is a widely performed procedure that involves either diagnosis of suspicious lesions or guidance for minimally invasive surgery in a variety of organs within the body cavity. Endoscopy may also be used to guide the introduction of certain items (e.g., stents) into the body. Endoscopic navigation systems seek to integrate

    更新日期:2018-06-04
  • Platelet Mechanotransduction
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Caroline E. Hansen, Yongzhi Qiu, Owen J.T. McCarty, Wilbur A. Lam

    The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand–receptor interactions governing the recruitment, activation, and aggregation of platelets. The physical biology of each step is distinct in that the recruitment

    更新日期:2018-06-04
  • Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Josef R. Bober, Chase L. Beisel, Nikhil U. Nair

    An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics

    更新日期:2018-06-04
  • Circulating Tumor Cells: Diagnostic and Therapeutic Applications
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Eric Lin, Thong Cao, Sunitha Nagrath, Michael R. King

    Metastasis contributes to poor prognosis in many types of cancer and is the leading cause of cancer-related deaths. Tumor cells metastasize to distant sites via the circulatory and lymphatic systems. In this review, we discuss the potential of circulating tumor cells for diagnosis and describe the experimental therapeutics that aim to target these disseminating cancer cells. We discuss the advantages

    更新日期:2018-06-04
  • Inorganic Nanomaterials for Soft Tissue Repair and Regeneration
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Russell Urie, Deepanjan Ghosh, Inam Ridha, Kaushal Rege

    Inorganic nanomaterials have witnessed significant advances in areas of medicine including cancer therapy, imaging, and drug delivery, but their use in soft tissue repair and regeneration is in its infancy. Metallic, ceramic, and carbon allotrope nanoparticles have shown promise in facilitating tissue repair and regeneration. Inorganic nanomaterials have been employed to improve stem cell engraftment

    更新日期:2018-06-04
  • Structural DNA Nanotechnology: Artificial Nanostructures for Biomedical Research
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Yonggang Ke, Carlos Castro, Jong Hyun Choi

    Structural DNA nanotechnology utilizes synthetic or biologic DNA as designer molecules for the self-assembly of artificial nanostructures. The field is founded upon the specific interactions between DNA molecules, known as Watson–Crick base pairing. After decades of active pursuit, DNA has demonstrated unprecedented versatility in constructing artificial nanostructures with significant complexity and

    更新日期:2018-06-04
  • Physiology and Engineering of the Graded Interfaces of Musculoskeletal Junctions
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Edward D. Bonnevie, Robert L. Mauck

    The connective tissues of the musculoskeletal system can be grouped into fibrous, cartilaginous, and calcified tissues. While each tissue type has a distinct composition and function, the intersections between these tissues result in the formation of complex, composite, and graded junctions. The complexity of these interfaces is a critical aspect of their healthy function, but poses a significant challenge

    更新日期:2018-06-04
  • Arterial Venous Differentiation for Vascular Bioengineering.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-06-04
    Laura Niklason,Guohao Dai

    The development processes of arteries and veins are fundamentally different, leading to distinct differences in anatomy, structure, and function as well as molecular profiles. Understanding the complex interaction between genetic and epigenetic pathways, as well as extracellular and biomechanical signals that orchestrate arterial venous differentiation, is not only critical for the understanding of

    更新日期:2018-06-04
  • Engineering Approaches to Study Cellular Decision Making.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2018-01-12
    Pamela K Kreeger,Laura E Strong,Kristyn S Masters

    In their native environment, cells are immersed in a complex milieu of biochemical and biophysical cues. These cues may include growth factors, the extracellular matrix, cell-cell contacts, stiffness, and topography, and they are responsible for regulating cellular behaviors such as adhesion, proliferation, migration, apoptosis, and differentiation. The decision-making process used to convert these

    更新日期:2018-06-04
  • Engineering Hydrogel Microenvironments to Recapitulate the Stem Cell Niche.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2017-12-08
    Christopher M Madl,Sarah C Heilshorn

    Stem cells are a powerful resource for many applications including regenerative medicine, patient-specific disease modeling, and toxicology screening. However, eliciting the desired behavior from stem cells, such as expansion in a naïve state or differentiation into a particular mature lineage, remains challenging. Drawing inspiration from the native stem cell niche, hydrogel platforms have been developed

    更新日期:2018-06-04
  • Advances in Imaging Brain Metabolism
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2017-06-20
    Fahmeed Hyder, Douglas L. Rothman

    Metabolism is central to neuroimaging because it can reveal pathways by which neuronal and glial cells use nutrients to fuel their growth and function. We focus on advanced magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods used in brain metabolic studies. 17O-MRS and 31P-MRS, respectively, provide rates of oxygen use and ATP synthesis inside mitochondria, whereas 19F-MRS

    更新日期:2017-06-20
  • Regulation of Energy Homeostasis After Gastric Bypass Surgery
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2017-06-20
    Martin L. Yarmush, Matthew D'Alessandro, Nima Saeidi

    The obesity epidemic continues to escalate each year in the United States more than anywhere else in the world. The existing pharmaceutical and other nonsurgical treatments for morbid obesity produce suboptimal physiologic outcomes compared with those of Roux-en-Y gastric bypass (RYGB) surgery. RYGB has been the gold standard of bariatric surgery because the beneficial long-term outcomes, which include

    更新日期:2017-06-20
  • Multiscale Modeling of Muscular-Skeletal Systems
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2017-06-20
    Gang Seob Jung, Markus J. Buehler

    Multiscale modeling of muscular-skeletal systems—the materials and structures that help organisms support themselves and move—is a rapidly growing field of study that has contributed key elements to the understanding of these systems, especially from a multiscale perspective. The systems, including materials such as bone and muscle, have hierarchical structures ranging from the nano- to the macroscale

    更新日期:2017-06-20
  • Thrombus Formation at High Shear Rates
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2017-06-20
    Lauren D.C. Casa, David N. Ku

    The final common pathway in myocardial infarction and ischemic stroke is occlusion of blood flow from a thrombus forming under high shear rates in arteries. A high-shear thrombus forms rapidly and is distinct from the slow formation of coagulation that occurs in stagnant blood. Thrombosis at high shear rates depends primarily on the long protein von Willebrand factor (vWF) and platelets, with hemodynamics

    更新日期:2017-06-20
  • Design Approaches to Myocardial and Vascular Tissue Engineering
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2017-06-20
    Olukemi O. Akintewe, Erin G. Roberts, Nae-Gyune Rim, Michael A.H. Ferguson, Joyce Y. Wong

    Engineered tissues represent an increasingly promising therapeutic approach for correcting structural defects and promoting tissue regeneration in cardiovascular diseases. One of the challenges associated with this approach has been the necessity for the replacement tissue to promote sufficient vascularization to maintain functionality after implantation. This review highlights a number of promising

    更新日期:2017-06-20
  • Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2017-06-20
    Michael Levin,Giovanni Pezzulo,Joshua M Finkelstein

    Living systems exhibit remarkable abilities to self-assemble, regenerate, and remodel complex shapes. How cellular networks construct and repair specific anatomical outcomes is an open question at the heart of the next-generation science of bioengineering. Developmental bioelectricity is an exciting emerging discipline that exploits endogenous bioelectric signaling among many cell types to regulate

    更新日期:2017-06-20
  • Objective Assessment of Surgical Technical Skill and Competency in the Operating Room
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2017-06-20
    S. Swaroop Vedula, Masaru Ishii, Gregory D. Hager

    Training skillful and competent surgeons is critical to ensure high quality of care and to minimize disparities in access to effective care. Traditional models to train surgeons are being challenged by rapid advances in technology, an intensified patient-safety culture, and a need for value-driven health systems. Simultaneously, technological developments are enabling capture and analysis of large

    更新日期:2017-06-20
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