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  • Point-of-Care Devices to Detect Zika and Other Emerging Viruses.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Helena de Puig,Irene Bosch,James J Collins,Lee Gehrke

    Rapid diagnostic tests (point-of-care devices) are critical components of informed patient care and public health monitoring (surveillance applications). We propose that among the many rapid diagnostics platforms that have been tested or are in development, lateral flow immunoassays and synthetic biology–based diagnostics (including CRISPR-based diagnostics) represent the best overall options given

    更新日期:2020-06-05
  • Integrated Biophysical Modeling and Image Analysis: Application to Neuro-Oncology.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Andreas Mang,Spyridon Bakas,Shashank Subramanian,Christos Davatzikos,George Biros

    Central nervous system (CNS) tumors come with vastly heterogeneous histologic, molecular, and radiographic landscapes, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics have shown promise in better characterizing the molecular, spatial, and temporal heterogeneity of tumors. Integrative analysis of CNS tumors, including clinically

    更新日期:2020-06-05
  • Micromechanobiology: Focusing on the Cardiac Cell-Substrate Interface.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Erica A Castillo,Kerry V Lane,Beth L Pruitt

    Engineered, in vitro cardiac cell and tissue systems provide test beds for the study of cardiac development, cellular disease processes, and drug responses in a dish. Much effort has focused on improving the structure and function of engineered cardiomyocytes and heart tissues. However, these parameters depend critically on signaling through the cellular microenvironment in terms of ligand composition

    更新日期:2020-06-05
  • Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Vitaliy L Rayz,Aaron A Cohen-Gadol

    In the last two decades, numerous studies have conducted patient-specific computations of blood flow dynamics in cerebral aneurysms and reported correlations between various hemodynamic metrics and aneurysmal disease progression or treatment outcomes. Nevertheless, intra-aneurysmal flow analysis has not been adopted in current clinical practice, and hemodynamic factors usually are not considered in

    更新日期:2020-06-05
  • Engineering Approaches for Addressing Opioid Use Disorder in the Community.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Paul M Griffin

    Many communities in the United States are struggling to deal with the negative consequences of illicit opioid use. Effectively addressing this epidemic requires the coordination and support of community stakeholders in a change process with common goals and objectives, continuous engagement with individuals with opioid use disorder (OUD) through their treatment and recovery journeys, application of

    更新日期:2020-06-05
  • Physiological Modeling and Simulation-Validation, Credibility, and Application.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    W Andrew Pruett,John S Clemmer,Robert L Hester

    In this review, we discuss the science of model validation as it applies to physiological modeling. There is widespread disagreement and ambiguity about what constitutes model validity. In areas in which models affect real-world decision-making, including within the clinic, in regulatory science, or in the design and engineering of novel therapeutics, this question is of critical importance. Without

    更新日期:2020-06-05
  • Three-Dimensional Single-Molecule Localization Microscopy in Whole-Cell and Tissue Specimens.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Sheng Liu,Hyun Huh,Sang-Hyuk Lee,Fang Huang

    Super-resolution microscopy techniques are versatile and powerful tools for visualizing organelle structures, interactions, and protein functions in biomedical research. However, whole-cell and tissue specimens challenge the achievable resolution and depth of nanoscopy methods. We focus on three-dimensional single-molecule localization microscopy and review some of the major roadblocks and developing

    更新日期:2020-06-05
  • Sparse Data-Driven Learning for Effective and Efficient Biomedical Image Segmentation.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    John A Onofrey,Lawrence H Staib,Xiaojie Huang,Fan Zhang,Xenophon Papademetris,Dimitris Metaxas,Daniel Rueckert,James S Duncan

    Sparsity is a powerful concept to exploit for high-dimensional machine learning and associated representational and computational efficiency. Sparsity is well suited for medical image segmentation. We present a selection of techniques that incorporate sparsity, including strategies based on dictionary learning and deep learning, that are aimed at medical image segmentation and related quantification

    更新日期:2020-06-05
  • 4D Flow with MRI.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Gilles Soulat,Patrick McCarthy,Michael Markl

    Magnetic resonance imaging (MRI) has become an important tool for the clinical evaluation of patients with cardiac and vascular diseases. Since its introduction in the late 1980s, quantitative flow imaging with MRI has become a routine part of standard-of-care cardiothoracic and vascular MRI for the assessment of pathological changes in blood flow in patients with cardiovascular disease. More recently

    更新日期:2020-06-05
  • Transgenic and Diet-Enhanced Silk Production for Reinforced Biomaterials: A Metamaterial Perspective.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Jung Woo Leem,Malcolm J Fraser,Young L Kim

    Silk fibers, which are protein-based biopolymers produced by spiders and silkworms, are fascinating biomaterials that have been extensively studied for numerous biomedical applications. Silk fibers often have remarkable physical and biological properties that typical synthetic materials do not exhibit. These attributes have prompted a wide variety of silk research, including genetic engineering, biotechnological

    更新日期:2020-06-05
  • The New Age of Cell-Free Biology.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Vincent Noireaux,Allen P Liu

    The cell-free molecular synthesis of biochemical systems is a rapidly growing field of research. Advances in the Human Genome Project, DNA synthesis, and other technologies have allowed the in vitro construction of biochemical systems, termed cell-free biology, to emerge as an exciting domain of bioengineering. Cell-free biology ranges from the molecular to the cell-population scales, using an ever-expanding

    更新日期:2020-06-05
  • Mitigating the Consequences of Subconcussive Head Injuries.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Eric A Nauman,Thomas M Talavage,Paul S Auerbach

    Subconcussive head injury represents a pathophysiology that spans the expertise of both clinical neurology and biomechanical engineering. From both viewpoints, the terms injury and damage, presented without qualifiers, are synonymously taken to mean a tissue alteration that may be recoverable. For clinicians, concussion is evolving from a purely clinical diagnosis to one that requires objective measurement

    更新日期:2020-06-05
  • Elastin-Like Polypeptides for Biomedical Applications.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Anastasia K Varanko,Jonathan C Su,Ashutosh Chilkoti

    Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties—including lower critical solution temperature phase behavior and minimal immunogenicity—make them attractive materials for a variety of biomedical applications. ELPs also benefit from recombinant synthesis and genetically encoded design; these enable control over the molecular weight

    更新日期:2020-06-05
  • Computer-Aided Design of Microfluidic Circuits.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Elishai Ezra Tsur

    Microfluidic devices developed over the past decade feature greater intricacy, increased performance requirements, new materials, and innovative fabrication methods. Consequentially, new algorithmic and design approaches have been developed to introduce optimization and computer-aided design to microfluidic circuits: from conceptualization to specification, synthesis, realization, and refinement. The

    更新日期:2020-06-05
  • Swine Disease Models for Optimal Vascular Engineering.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Michael Sturek,Mouhamad Alloosh,Frank W Sellke

    Swine disease models are essential for mimicry of human metabolic and vascular pathophysiology, thereby enabling high-fidelity translation to human medicine. The worldwide epidemic of obesity, metabolic disease, and diabetes has prompted the focus on these diseases in this review. We highlight the remarkable similarity between Ossabaw miniature swine and humans with metabolic syndrome and atherosclerosis

    更新日期:2020-06-05
  • Layer-by-Layer Biomaterials for Drug Delivery.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2020-06-05
    Dahlia Alkekhia,Paula T Hammond,Anita Shukla

    Controlled drug delivery formulations have revolutionized treatments for a range of health conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as one of the most versatile fabrication methods used to develop multifunctional controlled drug release coatings. The numerous advantages of LbL include its ability to incorporate and preserve biological activity of therapeutic

    更新日期:2020-06-05
  • Human Positron Emission Tomography Neuroimaging.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Jacob M Hooker,Richard E Carson

    Neuroimaging with positron emission tomography (PET) is the most powerful tool for understanding pharmacology, neurochemistry, and pathology in the living human brain. This technology combines high-resolution scanners to measure radioactivity throughout the human body with specific, targeted radioactive molecules, which allow measurements of a myriad of biological processes in vivo. While PET brain

    更新日期:2020-04-21
  • Intracranial Pressure and Intracranial Elastance Monitoring in Neurocritical Care.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Thomas Heldt,Tommaso Zoerle,Daniel Teichmann,Nino Stocchetti

    Patients with acute brain injuries tend to be physiologically unstable and at risk of rapid and potentially life-threatening decompensation due to shifts in intracranial compartment volumes and consequent intracranial hypertension. Invasive intracranial pressure (ICP) monitoring therefore remains a cornerstone of modern neurocritical care, despite the attendant risks of infection and damage to brain

    更新日期:2020-04-21
  • The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Caroline A Murphy,Atul K Garg,Joana Silva-Correia,Rui L Reis,Joaquim M Oliveira,Maurice N Collins

    The treatment of meniscus injuries has recently been facing a paradigm shift toward the field of tissue engineering, with the aim of regenerating damaged and diseased menisci as opposed to current treatment techniques. This review focuses on the structure and mechanics associated with the meniscus. The meniscus is defined in terms of its biological structure and composition. Biomechanics of the meniscus

    更新日期:2020-04-21
  • Controlling Matter at the Molecular Scale with DNA Circuits.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Dominic Scalise,Rebecca Schulman

    In recent years, a diverse set of mechanisms have been developed that allow DNA strands with specific sequences to sense information in their environment and to control material assembly, disassembly, and reconfiguration. These sequences could serve as the inputs and outputs for DNA computing circuits, enabling DNA circuits to act as chemical information processors to program complex behavior in chemical

    更新日期:2020-04-21
  • The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Melanie Maurer,Jan Lammerding

    Cellular behavior is continuously affected by microenvironmental forces through the process of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical responses. Mounting evidence suggests that the nucleus itself is a mechanoresponsive element, reacting to cytoskeletal forces and mediating downstream biochemical responses. The nucleus responds through a host of mechanisms

    更新日期:2020-04-21
  • A Contemporary Look at Biomechanical Models of Myocardium.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Reza Avazmohammadi,João S Soares,David S Li,Samarth S Raut,Robert C Gorman,Michael S Sacks

    Understanding and predicting the mechanical behavior of myocardium under healthy and pathophysiological conditions are vital to developing novel cardiac therapies and promoting personalized interventions. Within the past 30 years, various constitutive models have been proposed for the passive mechanical behavior of myocardium. These models cover a broad range of mathematical forms, microstructural

    更新日期:2020-04-21
  • Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Jana Ognjenović,Reinhard Grisshammer,Sriram Subramaniam

    In recent years, cryo electron microscopy (cryo-EM) technology has been transformed with the development of better instrumentation, direct electron detectors, improved methods for specimen preparation, and improved software for data analysis. Analyses using single-particle cryo-EM methods have enabled determination of structures of proteins with sizes smaller than 100 kDa and resolutions of ∼2 Å in

    更新日期:2020-04-21
  • Single-Cell Omics Analyses Enabled by Microchip Technologies.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Yanxiang Deng,Amanda Finck,Rong Fan

    Single-cell omics studies provide unique information regarding cellular heterogeneity at various levels of the molecular biology central dogma. This knowledge facilitates a deeper understanding of how underlying molecular and architectural changes alter cell behavior, development, and disease processes. The emerging microchip-based tools for single-cell omics analysis are enabling the evaluation of

    更新日期:2020-04-21
  • Digital Manufacturing for Microfluidics.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Arman Naderi,Nirveek Bhattacharjee,Albert Folch

    The microfluidics field is at a critical crossroads. The vast majority of microfluidic devices are presently manufactured using micromolding processes that work very well for a reduced set of biocompatible materials, but the time, cost, and design constraints of micromolding hinder the commercialization of many devices. As a result, the dissemination of microfluidic technology-and its impact on society-is

    更新日期:2020-04-21
  • Skin-Mountable Biosensors and Therapeutics: A Review.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Eun Kwang Lee,Min Ku Kim,Chi Hwan Lee

    Miniaturization of electronic components and advances in flexible and stretchable materials have stimulated the development of wearable health care systems that can reflect and monitor personal health status by health care professionals. New skin-mountable devices that offer seamless contact onto the human skin, even under large deformations by natural motions of the wearer, provide a route for both

    更新日期:2020-04-21
  • Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Nikhil Jain,Jens Moeller,Viola Vogel

    In addition to their early-recognized functions in host defense and the clearance of apoptotic cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If misregulated, they steer the progression of many inflammatory diseases. Much progress has been made in understanding the mechanisms underlying macrophage signaling, transcriptomics, and proteomics, under physiological

    更新日期:2020-04-21
  • Programming Stimuli-Responsive Behavior into Biomaterials.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Barry A Badeau,Cole A DeForest

    Stimuli-responsive materials undergo triggered changes when presented with specific environmental cues. These dynamic systems can leverage biological signals found locally within the body as well as exogenous cues administered with spatiotemporal control, providing powerful opportunities in next-generation diagnostics and personalized medicine. Here, we review the synthetic and strategic advances used

    更新日期:2020-04-21
  • Challenges and Opportunities in the Design of Liver-on-Chip Microdevices.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Avner Ehrlich,Daniel Duche,Gladys Ouedraogo,Yaakov Nahmias

    The liver is the central hub of xenobiotic metabolism and consequently the organ most prone to cosmetic- and drug-induced toxicity. Failure to detect liver toxicity or to assess compound clearance during product development is a major cause of postmarketing product withdrawal, with disastrous clinical and financial consequences. While small animals are still the preferred model in drug development

    更新日期:2020-04-21
  • Frontiers of Medical Robotics: From Concept to Systems to Clinical Translation.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Jocelyne Troccaz,Giulio Dagnino,Guang-Zhong Yang

    Medical robotics is poised to transform all aspects of medicine-from surgical intervention to targeted therapy, rehabilitation, and hospital automation. A key area is the development of robots for minimally invasive interventions. This review provides a detailed analysis of the evolution of interventional robots and discusses how the integration of imaging, sensing, and robotics can influence the patient

    更新日期:2020-04-21
  • Biomaterials: Been There, Done That, and Evolving into the Future.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Buddy D Ratner

    Biomaterials as we know them today had their origins in the late 1940s with off-the-shelf commercial polymers and metals. The evolution of materials for medical applications from these simple origins has been rapid and impactful. This review relates some of the early history; addresses concerns after two decades of development in the twenty-first century; and discusses how advanced technologies in

    更新日期:2020-04-21
  • Hydrogel-Based Strategies to Advance Therapies for Chronic Skin Wounds.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Lucília P da Silva,Rui L Reis,Vitor M Correlo,Alexandra P Marques

    Chronic skin wounds are the leading cause of nontraumatic foot amputations worldwide and present a significant risk of morbidity and mortality due to the lack of efficient therapies. The intrinsic characteristics of hydrogels allow them to benefit cutaneous healing essentially by supporting a moist environment. This property has long been explored in wound management to aid in autolytic debridement

    更新日期:2020-04-21
  • New Sensor and Wearable Technologies to Aid in the Diagnosis and Treatment Monitoring of Parkinson's Disease.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Mariana H G Monje,Guglielmo Foffani,José Obeso,Álvaro Sánchez-Ferro

    Parkinson's disease (PD) is a degenerative disorder of the brain characterized by the impairment of the nigrostriatal system. This impairment leads to specific motor manifestations (i.e., bradykinesia, tremor, and rigidity) that are assessed through clinical examination, scales, and patient-reported outcomes. New sensor-based and wearable technologies are progressively revolutionizing PD care by objectively

    更新日期:2020-04-21
  • The Biocompatibility Challenges in the Total Artificial Heart Evolution.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Eleonora Dal Sasso,Andrea Bagno,Silvia T G Scuri,Gino Gerosa,Laura Iop

    There are limited therapeutic options for final treatment of end-stage heart failure. Among them, implantation of a total artificial heart (TAH) is an acceptable strategy when suitable donors are not available. TAH development began in the 1930s, followed by a dramatic evolution of the actuation mechanisms operating the mechanical pumps. Nevertheless, the performance of TAHs has not yet been optimized

    更新日期:2020-04-21
  • Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Kinam Park,Andrew Otte

    Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent technologies to combat the current opioid epidemic. These abuse-deterrent formulations (ADFs) are intended to deter physical and chemical tampering of opioid-based products, while still providing safe and effective delivery for therapeutic purposes

    更新日期:2020-04-21
  • Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Marc A Simon,Timothy N Bachman,John Watson,J Timothy Baldwin,William R Wagner,Harvey S Borovetz

    Our review in the 2008 volume of this journal detailed the use of mechanical circulatory support (MCS) for treatment of heart failure (HF). MCS initially utilized bladder-based blood pumps generating pulsatile flow; these pulsatile flow pumps have been supplanted by rotary blood pumps, in which cardiac support is generated via the high-speed rotation of computationally designed blading. Different rotary

    更新日期:2020-04-21
  • Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2019-06-05
    Lindong Weng,Shannon L Stott,Mehmet Toner

    Successful stabilization and preservation of biological materials often utilize low temperatures and dehydration to arrest molecular motion. Cryoprotectants are routinely employed to help the biological entities survive the physicochemical and mechanical stresses induced by cold or dryness. Molecular interactions between biomolecules, cryoprotectants, and water fundamentally determine the outcomes

    更新日期:2020-04-21
  • Injury biomechanics and child abuse.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-09-10
    Mary Clyde Pierce,Gina Bertocci

    Child abuse is a leading cause of morbidity and mortality in young children and infants in the United States. Medical care providers, social services, and legal systems make critical decisions regarding injury and history plausibility daily. Injury plausibility judgments rely on evidence-based medicine, individualized experiences, and empirical data. A poor outcome may result if abuse is missed or

    更新日期:2019-11-01
  • Chemical exchange saturation transfer contrast agents for magnetic resonance imaging.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-07-24
    A Dean Sherry,Mark Woods

    Magnetic resonance imaging (MRI) contrast agents have become an important tool in clinical medicine. The most common agents are Gd(3+)-based complexes that shorten bulk water T(1) by rapid exchange of a single inner-sphere water molecule with bulk solvent water. Current gadolinium agents lack tissue specificity and typically do not respond to their chemical environment. Recently, it has been demonstrated

    更新日期:2019-11-01
  • Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-07-24
    J D Humphrey,C A Taylor

    Intracranial saccular and abdominal aortic aneurysms (ISAs and AAAs, respectively) result from different underlying disease processes and exhibit different rupture potentials, yet they share many histopathological and biomechanical characteristics. Moreover, as in other vascular diseases, hemodynamics and wall mechanics play important roles in the natural history and possible treatment of these two

    更新日期:2019-11-01
  • Molecular engineering of viral gene delivery vehicles.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-07-24
    David V Schaffer,James T Koerber,Kwang-il Lim

    Viruses can be engineered to efficiently deliver exogenous genes, but their natural gene delivery properties often fail to meet human therapeutic needs. Therefore, engineering viral vectors with new properties, including enhanced targeting abilities and resistance to immune responses, is a growing area of research. This review discusses protein engineering approaches to generate viral vectors with

    更新日期:2019-11-01
  • Ultralow-power electronics for biomedical applications.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-07-24
    Anantha P Chandrakasan,Naveen Verma,Denis C Daly

    The electronics of a general biomedical device consist of energy delivery, analog-to-digital conversion, signal processing, and communication subsystems. Each of these blocks must be designed for minimum energy consumption. Specific design techniques, such as aggressive voltage scaling, dynamic power-performance management, and energy-efficient signaling, must be employed to adhere to the stringent

    更新日期:2019-11-01
  • Bacterial quorum sensing: signals, circuits, and implications for biofilms and disease.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-07-24
    Arul Jayaraman,Thomas K Wood

    Communication between bacteria, belonging to the same species or to different species, is mediated through different chemical signals that are synthesized and secreted by bacteria. These signals can either be cell-density related (autoinducers) or be produced by bacteria at different stages of growth, and they allow bacteria to monitor their environment and alter gene expression to derive a competitive

    更新日期:2019-11-01
  • Current and future considerations in the use of mechanical circulatory support devices.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-07-24
    Marc A Simon,John Watson,J Timothy Baldwin,William R Wagner,Harvey S Borovetz

    Heart failure (HF) is a major public health problem in the United States, and its prevalence is likely to increase with the aging U.S. population. Mechanical circulatory support (MCS) utilizing bladder-based blood pumps generating pulsatile flow has been reserved for patients with severe HF failing medical therapy. As MCS technology has advanced to include rotary blood pumps, so has our understanding

    更新日期:2019-11-01
  • Catch bonds in adhesion.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-07-24
    Wendy Thomas

    One of the most exciting discoveries in biological adhesion is the recent and counter-intuitive observation that the lifetimes of some biological adhesive bonds, called catch bonds, are enhanced by tensile mechanical force. At least two types of adhesive proteins have been shown to form catch bonds--blood proteins called selectins and a bacterial protein called FimH. Both mediate shear-enhanced adhesion

    更新日期:2019-11-01
  • Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-07-24
    Yingxiao Wang,John Y-J Shyy,Shu Chien

    Fluorescence proteins (FPs) have been widely used for live-cell imaging in the past decade. This review summarizes the recent advances in FP development and imaging technologies using FPs to monitor molecular localization and activities and gene expressions in live cells. We also discuss the utilization of FPs to develop molecular biosensors and the principles and application of advanced technologies

    更新日期:2019-11-01
  • Quantitative imaging of musculoskeletal tissue.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-05-10
    Peter Augat,Felix Eckstein

    Quantitative imaging of musculoskeletal tissue, including radiography, computed tomography (CT), and magnetic resonance imaging (MRI), has become the essential methodology in clinical practice for diagnosis and monitoring of various musculoskeletal conditions. Furthermore, quantitative imaging technologies have become indispensable for research and development in diseases of the human skeleton. Standardized

    更新日期:2019-11-01
  • Neural stimulation and recording electrodes.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-04-24
    Stuart F Cogan

    Electrical stimulation of nerve tissue and recording of neural electrical activity are the basis of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and neurological disorders. An understanding of the electrochemical mechanisms underlying the behavior of neural stimulation and recording electrodes is important for the development of chronically implanted devices

    更新日期:2019-11-01
  • Psychophysical evaluation for visual prosthesis.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-04-24
    Gislin Dagnelie

    Vision restoration through retinal, optic nerve, and cortical implants is no longer just the stuff of fantasy. The design and development of visual prostheses rapidly move from the engineering phase toward preclinical and clinical trials, yet the benchmarks to determine their efficacy in blind research subjects have received very little attention, and likewise the selection criteria and preparation

    更新日期:2019-11-01
  • Fluorescence imaging of membrane dynamics.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-04-24
    Jay T Groves,Raghuveer Parthasarathy,Martin B Forstner

    Imaging membrane dynamics is an important goal, motivated by the abundance of biochemical and biophysical events that are orchestrated at, or by, cellular membranes. The short length scales, fast timescales, and environmental requirements of membrane phenomena present challenges to imaging experiments. Several technical advances offer means to overcome these challenges, and we describe here three powerful

    更新日期:2019-11-01
  • Targeted drug-aerosol delivery in the human respiratory system.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-04-17
    C Kleinstreuer,Z Zhang,J F Donohue

    Inhalation of drug aerosols is a modern pathway to combat lung diseases. It is also becoming the preferred route for insulin delivery, pain management, cancer therapy, and nanotherapeutics. Popular delivery devices include nebulizers, metered-dose inhalers, and dry-powder inhalers. They are all nondirectional and hence have typically low particle deposition efficiencies in desired nasal or lung areas

    更新日期:2019-11-01
  • Point-of-care diagnostics for global health.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2008-03-25
    Paul Yager,Gonzalo J Domingo,John Gerdes

    Biomedical engineers have traditionally developed technologies in response to the needs of the developed world's medical community. As a result, the diagnostic systems on which they have worked have met the requirements of well-funded laboratories in highly regulated and quality-assessed environments. However, such approaches do not address the needs of the majority of the world's people afflicted

    更新日期:2019-11-01
  • Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2007-07-27
    Katherine Ferrara,Rachel Pollard,Mark Borden

    This review offers a critical analysis of the state of the art of medical microbubbles and their application in therapeutic delivery and monitoring. When driven by an ultrasonic pulse, these small gas bubbles oscillate with a wall velocity on the order of tens to hundreds of meters per second and can be deflected to a vessel wall or fragmented into particles on the order of nanometers. While single-session

    更新日期:2019-11-01
  • Injury biomechanics and child abuse.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2007-05-18
    Mary Clyde Pierce,Gina Bertocci

    Child abuse is a leading cause of morbidity and mortality in young children and infants in the United States. Medical care providers, social services, and legal systems make critical decisions regarding injury and history plausibility daily. Injury plausibility judgments rely on evidence-based medicine, individualized experiences, and empirical data. A poor outcome may result if abuse is missed or

    更新日期:2019-11-01
  • Breast CT.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2007-05-18
    Stephen J Glick

    Breast cancer is a serious disease that accounts for approximately 40,000 deaths per year in the United States. Unfortunately, there is no known cause of breast cancer, and therefore the best way to prevent mortality is early detection. In the past 15 years, breast cancer mortality has been reduced significantly, which is in part due to screening with film-screen mammography. Nonetheless, conventional

    更新日期:2019-11-01
  • Cell mechanics: integrating cell responses to mechanical stimuli.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2007-04-28
    Paul A Janmey,Christopher A McCulloch

    Forces are increasingly recognized as major regulators of cell structure and function, and the mechanical properties of cells are essential to the mechanisms by which cells sense forces, transmit them to the cell interior or to other cells, and transduce them into chemical signals that impact a spectrum of cellular responses. Comparison of the mechanical properties of intact cells with those of the

    更新日期:2019-11-01
  • Current state of imaging protein-protein interactions in vivo with genetically encoded reporters.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2007-04-28
    Victor Villalobos,Snehal Naik,David Piwnica-Worms

    Signaling pathways regulating proliferation, differentiation, and inflammation are commonly mediated through protein-protein interactions as well as reversible modification (e.g., phosphorylation) of proteins. To facilitate the study of regulated protein-protein interactions in cells and living animals, new imaging tools, many based on optical signals and capable of quantifying protein interactions

    更新日期:2019-11-01
  • Interstitial flow and its effects in soft tissues.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2007-04-27
    Melody A Swartz,Mark E Fleury

    Interstitial flow plays important roles in the morphogenesis, function, and pathogenesis of tissues. To investigate these roles and exploit them for tissue engineering or to overcome barriers to drug delivery, a comprehensive consideration of the interstitial space and how it controls and affects such processes is critical. Here we attempt to review the many physical and mathematical correlations that

    更新日期:2019-11-01
  • Forensic injury biomechanics.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2007-04-24
    Wilson C Hayes,Mark S Erickson,Erik D Power

    Forensic injury biomechanics is the science that relates mechanical forces to disruption of anatomical regions of the human body. In this review, we introduce (a) how scaling techniques can be used to describe injury severity and probability of death; (b) how a simple ratio, the factor of risk, and more sophisticated injury risk functions can be used to determine the probability of injury; and (c)

    更新日期:2019-11-01
  • Noninvasive human brain stimulation.
    Annu. Rev. Biomed. Eng. (IF 15.541) Pub Date : 2007-04-21
    Timothy Wagner,Antoni Valero-Cabre,Alvaro Pascual-Leone

    Noninvasive brain stimulation with transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS) is valuable in research and has potential therapeutic applications in cognitive neuroscience, neurophysiology, psychiatry, and neurology. TMS allows neurostimulation and neuromodulation, while tDCS is a purely neuromodulatory application. TMS and tDCS allow diagnostic and interventional

    更新日期:2019-11-01
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