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Dietary Restriction Delays But Cannot Heal Irradiation-Induced Hair Graying by Preserving Hair Follicle Stem Cells in Quiescence. Rejuvenation Res. (IF 2.6) Pub Date : 2023-11-29 Rongrong Qiu,Xingxing Qiu,Mingyue Su,Man Sun,Yiting Wang,Jianying Wu,Hua Wang,Duozhuang Tang,Si Tao
DNA damage represents one of the cell intrinsic causes of stem cell aging, which leads to differentiation-induced removal of damaged stem cells in skin and blood. Dietary restriction (DR) retards aging across various species, including several strains of laboratory mice. Whether, DR has the potential to ameliorate DNA damage-driven stem cell exhaustion remains incompletely understood. In this study
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The Longevist - Highlight on a development in the field. Rejuvenation Res. (IF 2.6) Pub Date : 2023-11-19 Rhys Anderson
n/a.
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Advancing a cross-sector, societal movement to redirect research, medical science and healthcare to a new paradigm. Rejuvenation Res. (IF 2.6) Pub Date : 2023-11-11 Melissa King,Bernard Siegel,Eve Herold
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The divide-and-conquer approach to delaying age-related functional decline: where are we now? Rejuvenation Res. (IF 2.6) Pub Date : 2023-11-11 Aubrey de Grey
Over 20 years ago, together with seven illustrious colleagues, the author proposed that efforts to postpone the decline and debilitation of aging might most promisingly be pursued by tackling the various lifelong processes of accumulation of damage via a panel of interventions, rather than seeking a magic bullet that would retard them all. A decade later, this approach was embraced in a paper that
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The Association Between Sleep Duration and Sleep-Related Gene Methylation with Osteoporosis in Chinese Postmenopausal Women. Rejuvenation Res. (IF 2.6) Pub Date : 2023-11-08 Qianqian Ma,Ting Liu,Ying Li,Hongyu Xu,Qianqian Xiao,Qi Yao
This study aims to investigate the association between sleep duration and osteoporosis. In addition, sleep-related gene methylation was also detected in this study and we explored its relationship with osteoporosis. The epidemiological investigation section of this study was designed as a retrospective cross-sectional study. We gathered 148 postmenopausal women from two communities and used questionnaires
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Crosstalk between aging, circadian rhythm, and melatonin. Rejuvenation Res. (IF 2.6) Pub Date : 2023-10-17 Avnish Kumar Verma,Mohammad Idreesh Khan,Fauzia Ashfaq,Syed Ibrahim Rizvi
Circadian rhythms (CRs) are 24h periodic oscillations governed by an endogenous circadian pacemaker located in the suprachiasmatic nucleus (SCN) which organizes the physiology and behavior of organisms. Circadian rhythm disruption (CRD) is also indicative of the aging process. In mammals, melatonin is primarily synthesized in the pineal gland and participates in a variety of multifaceted intracellular
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Endocrine and Epigenetic Regulation as Common Pathways Underlying the Genetic Basis of Sleep Traits and Longevity. Rejuvenation Res. (IF 2.6) Pub Date : 2023-10-05 Mariana Moysés-Oliveira,Luana N G Adami,Pedro Guerreiro,Amanda Cristina Mosini,Anna Kloster,Lais Cunha,Mayara Paschalidis,Bruna Pereira Marquezini,Gabriel N Pires,Priscila F Tempaku,Monica L Andersen,Sergio Tufik
The amount of sleep needed over one's lifespan is age dependent and not sleeping enough or sleeping in excess is associated with increased morbidity and mortality. Yet, the convergent molecular mechanisms that link longevity and sleep are largely unknown. We performed a gene enrichment study that (1) identified genes associated with both longevity and sleep traits and (2) determined molecular pathways
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Intense Caloric Restriction from Birth Prevents Cardiovascular Aging in Rats. Rejuvenation Res. (IF 2.6) Pub Date : 2023-10-01 Dirceu de Sousa Melo,Liliane Costa Pereira,Carina Sousa Santos,Bruno Ferreira Mendes,Isaac Filipe Moreira Konig,Bruna Caroline Chaves Garcia,Ilkilene Pinheiro Queiroz,Lauane Gomes Moreno,Ricardo Cardoso Cassilhas,Elizabethe Adriana Esteves,Etel Rocha Vieira,Flávio de Castro Magalhães,Luciano Dos Santos Aggum Capettini,Ricardo Augusto Leoni De Sousa,Kinulpe Honorato Sampaio,Marco Fabrício Dias Peixoto
We previously demonstrated that a 50% caloric restriction (CR) from birth improves several cardiometabolic risk factors in young rats. In this study, we investigated in middle-aged rats the consequences of a 50% CR from birth on cardiometabolic risk factors, heart function/morphology, ventricular arrhythmia, and fibrillation incidence, and cardiac intracellular proteins involved with redox status and
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Heterochronic Plasma Transfer: Experimental Design, Considerations, and Technical Challenges. Rejuvenation Res. (IF 2.6) Pub Date : 2023-09-25 Victor A Ansere,Matthew P Bubak,Benjamin F Miller,Willard M Freeman
Experimental approaches such as Heterochronic Plasma Transfer (HPT) provide insights into the aging process and help identify the factors that impact aging, with the aim of developing anti-aging therapies. HPT involves the transfer of plasma from an animal of one age to an animal of a different age and highlights the effects of the systemic environment on aging. Despite its importance as an aging research
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Long-Term Survival and Functional Recovery of Cryopreserved Vascularized Groin Flap and Below-the-Knee Rat Limb Transplants. Rejuvenation Res. (IF 2.6) Pub Date : 2023-09-12 Amir Arav,Shujun Li,Or Friedman,Inna Solodeev,Jessie Aouizerate,Daniel Kedar,Marie De Antonio,Dity Natan,Eyal Gur,Nir Shani
Effective cryopreservation of large tissues, limbs, and organs has the potential to revolutionize medical post-trauma reconstruction options and organ preservation and transplantation procedures. To date, vitrification and directional freezing are the only viable methods for long-term organ or tissue preservation, but are of limited clinical relevance. This work aimed to develop a vitrification-based
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Development of a Novel Senolysis Approach Targeting the Senescent Fibroblast Marker HTR2A via Antibody-Dependent Cellular Cytotoxicity. Rejuvenation Res. (IF 2.6) Pub Date : 2023-08-01 Kento Takaya,Toru Asou,Kazuo Kishi
Abnormal remodeling of collagen and extracellular matrix caused by the accumulation of senescent fibroblasts in the dermis is the most likely cause of skin aging. Therefore, the application of "senolysis," in which only senescent cells are cleared from the body, has a potential in the development of antiaging treatments for skin. However, markers that label senescent fibroblasts only reflect the state
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Acarbose Mitigates Age-Dependent Alterations in Erythrocyte Membrane Transporters During Aging in Rats. Rejuvenation Res. (IF 2.6) Pub Date : 2023-06-12 Jitendra Kumar Arya,Raushan Kumar,Akanksha Singh,Parisha Srivastava,Arun Kumar Yadawa,Syed Ibrahim Rizvi
Acarbose (ACA), a well-studied and effective inhibitor of α-amylase and α-glucosidase, is a postprandial-acting antidiabetic medicine. The membrane of the erythrocyte is an excellent tool for analyzing different physiological and biochemical activities since it experiences a range of metabolic alterations throughout aging. It is uncertain if ACA modulates erythrocyte membrane activities in an age-dependent
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RETRACTED: Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage. Rejuvenation Res. (IF 2.6) Pub Date : 2023-06-06 Lingyan Qiu,Kai Chen,Xu Wang,Yun Zhao
The publisher of Rejuvenation Research officially retracts the article entitled, "Tangzhiqing-mediated NRF2 reduces autophagy-dependent ferroptosis to mitigate diabetes-related cognitive impairment neuronal damage," by Lingyan Qiu, Mr. Kai Chen, Prof. Xu Wang, and Ms. Yun Zhao. (Rejuvenation Res 2023; epub 6 Jun; doi: 10.1089/rej.2023.0013). After the acceptance and Instant Online publication of the
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Study on the Mechanism of Naoxintong in the Treatment of Cerebral Ischemia-Reperfusion Injury Based on a Multiomics Method. Rejuvenation Res. (IF 2.6) Pub Date : 2023-07-24 Huifen Zhou,Ningji Fang,Peng Zhou,Bingying Lin,Xiaoyu Wei,Wei Fu,Zhishan Ding,Jiehong Yang,Haitong Wan
Cerebral ischemia-reperfusion (CIR) injury occurs as a secondary injury during the treatment of ischemic stroke (IS). There is a high death rate and morbidity due to IS throughout the world. Even though Naoxintong Capsule (NXT) is effective in the treatment of CIR, its mechanisms of action are unclear. The study aims to explore the clear mechanism associated with NXT therapy for CIR. We established
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Epigenetic Modifiers as Game Changers for Healthy Aging. Rejuvenation Res. (IF 2.6) Pub Date : 2023-05-17 Shikha Sharma,Ramesh Bhonde
Epigenetic alterations during aging are manifested with altered gene expression linking it to lifespan regulation, genetic instability, and diseases. Diet and epigenetic modifiers exert a profound effect on the lifespan of an organism by modulating the epigenetic marks. However, our understanding of the multifactorial nature of the epigenetic process during aging and the onset of disease conditions
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Kai-Xin-San Improves Cognitive Impairment via Wnt/β-Catenin and IRE1/XBP1s Signalings in APP/PS1 Mice. Rejuvenation Res. (IF 2.6) Pub Date : 2023-05-23 Yu-Min Xu,Fang-Mei Lu,Hong-Cai Xu,Jie Zhang,Shang-Yan Hei,Yu-Hui Qiu,Ye-Feng Cai,Shi-Jie Zhang,Min Zhao
Alzheimer's disease (AD) is the most common type of dementia with an insidious onset and slow progression. Kai-Xin-San (KXS) has been reported to be effective in improving cognitive impairment in AD. However, the mechanism is still confused. In this study, we employed APP/PS1 mice to explore the neuroprotective mechanism of KXS. Forty-eight male APP/PS1 mice were randomly divided into model group,
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Alginate Oligosaccharides Enhance Autophagy to Rejuvenate H2O2-Induced Senescent IEC-6 Through the AMPK/mTOR Signaling Pathway. Rejuvenation Res. (IF 2.6) Pub Date : 2023-05-05 Xinxiu Zhao,Shixian Zhou,Shunmei Huang,Peixia Wang,Jie Mou,Caixia Gong,Xia Zhang,Qin Zhang,Yunmei Yang
Intestinal epithelial cellular senescence contributes to the physiological decline of intestine and induces age-associated intestinal diseases. Therefore, the intestine is a vital target to delay intestinal epithelial cellular senescence and extend healthy lifespan. Alginate oligosaccharides (AOSs) have a wide range of biological and pharmacological activities. However, there are no related reports
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Mapping the Landscape of Indian Genomics Research: A Scientometric Analysis. Rejuvenation Res. (IF 2.6) Pub Date : 2023-04-25 Bwsrang Basumatary,Pawan Kumar Maurya,Manoj Kumar Verma
This Scientometric study aimed to provide state-of-the-art information on research growth and trends, areas of potential growth and development in genomics in India, and identify the key players (organizations or institutions, and funding agencies). It was found that the number of publications and citations related to genomics research has been steadily increasing over the years, indicating a growing
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Hydroxysafflor yellow A exerts neuroprotective effect by reducing Aβ toxicity through inhibiting endoplasmic reticulum stress in oxygen‐glucose deprivation/reperfusion cell model Rejuvenation Res. (IF 2.6) Pub Date : 2023-02-03 Ms. Hui-Han Ma, Ms. Jun-Ru Wen, Mr. Hao Fang, Ms. Shan Su, Ms. Can Wan, Ms. Chao Zhang, Ms. Fang-Mei Lu, Ms. Ling-Ling Fan, Mr. Guang-Liang Wu, Ms. Zi-Yi Zhou, Dr. Lijun Qiao, Dr. Shi-Jie Zhang, Dr. Ye-Feng Cai
Ischemia stroke is thought to be one of vascular risks associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Hydroxysafflor yellow A (HSYA) has been reported to protect against stroke and AD, while the underlying mechanism remains unclear. In this study, SH-SY5Y cell model treated with oxygen glucose deprivation/reperfusion (OGD/R) was used to explore the potential mechanism
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Acarbose, an α-Glucosidase Inhibitor, Maintains Altered Redox Homeostasis During Aging by Targeting Glucose Metabolism in Rat Erythrocytes Rejuvenation Res. (IF 2.6) Pub Date : 2023-01-27 Jitendra Kumar Arya, Raushan Kumar, Akanksha Singh, Parisha Srivastava, Arun Kumar Yadawa, Syed Ibrahim Rizvi
Increasing age is the single largest risk factor for a variety of chronic illnesses. As a result, improving the capability to target the aging process leads to an increased health span. A lack of appropriate glucoregulatory control is a recurring issue associated with aging and chronic illness, even though many longevity therapies result in the preservation of glucoregulatory control. In this study
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Complement heat tolerance as a marker of protein fragility and its clinical significance Rejuvenation Res. (IF 2.6) Pub Date : 2023-01-21 Ms. Lijuan He, Ms. Xiaojun Jin, Prof. Hui Liu
Abstract Objective: This study aimed to establish a complement-tolerance test as a marker of protein fragility and discuss its clinical significance. Methods: Total complement activity (TCA) of serum was measured using a self-hemolysis colorimetric method. Human O-erythrocytes and rabbit anti-human O-erythrocyte antibodies were used to replace sheep erythrocytes and the corresponding hemolysin for
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Potential Antiaging and Hepatoprotective Effects of Acanthopanax senticosus Extracts in Adult Rat Models Rejuvenation Res. (IF 2.6) Pub Date : 2023-01-20 Chaeyeong Kim, Hye Min Bae, Inkyung Baik
Data regarding plant extracts with antiaging properties, particularly through the biological process involving telomeres and telomerase, are limited. Thus, this study aimed to investigate the effects of Acanthopanax senticosus extract (ASE) supplementation on leukocyte telomere length (LTL), telomerase, and inflammatory and metabolic markers in adult animal models. A freeze-dried product of ethanol
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Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model Rejuvenation Res. (IF 2.6) Pub Date : 2023-01-16 Kento Takaya, Tatsuyuki Ishii, Toru Asou, Kazuo Kishi
Chronic senescence, such as aging, contributes to age-related tissue dysfunction and disease development. The accumulation of senescent fibroblasts and the senescence-associated secretory phenotype is particularly implicated in this process. Removal of senescent cells has been reported to prevent tissue dysfunction and to extend the life span during aging. ABT-263 (navitoclax), which inhibits antiapoptotic
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Identification of Apolipoprotein D as a dermal fibroblast marker of human aging for development of skin rejuvenation therapy Rejuvenation Res. (IF 2.6) Pub Date : 2022-12-26 Dr. Kento Takaya, Dr. Toru Asou, Prof. Kazuo Kishi
The current understanding of skin aging is that senescent fibroblasts accumulate within the dermis and subcutaneous fat to cause abnormal tissue remodeling and extracellular matrix dysfunction, triggering a senescence-associated secretory phenotype (SASP). A novel therapeutic approach to prevent skin aging is to specifically eliminate senescent dermal fibroblasts; this requires the identification of
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Predictive value of combined plasma D-Dimer, SECUBE1 and right ventricular Tei-index for the prognosis of elderly patients with acute pulmonary thromboembolism Rejuvenation Res. (IF 2.6) Pub Date : 2022-12-14 Dr. Mei Yang, Dr. Yi Liu, Dr. Yuxia Ma, Dr. Wenhao Wang
Acute pulmonary thromboembolism (APTE) has become a non-negligible clinical concern due to its high mortality and complex symptoms. Early diagnosis and prognostic assessment of APTE are of great significance for the long-term benefits of patients, especially elderly patients. Elderly patients with pulmonary embolism (n=250) who presented to our hospital from January 2018 to July 2021 were recruited
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Association of Social Support Network with Telomere Length: A Cross-Sectional Study with Community-Dwelling Older Adults Rejuvenation Res. (IF 2.6) Pub Date : 2022-12-12 Alice Regina Costa Barbosa, Daniella Pires Nunes, Daniela Braga Lima, Fabio Antonio Colombo, Juliana Barbosa Nunes, Ariene Angelini dos Santos Orlandi, Greiciane da Silva Rocha, Daniele Sirineu Pereira, Ligiana Pires Corona, Tábatta Renata Pereira de Brito
Considering that telomere length can be determined not only by issues related to cell biology but also by aspects related to social factors and environmental exposures, studies on the relationship between social aspects and telomere length can help to better understand the still scarcely known aspects of the human aging process. Thus, this research seeks to verify whether social support networks are
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Neuroprotective Potential of Hydroalcoholic Extract of Centella asiatica Against 3-Nitropropionic Acid-Induced Huntington's Like Symptoms in Adult Zebrafish Rejuvenation Res. (IF 2.6) Pub Date : 2022-12-12 Vishal Kumar, Charan Singh, Arti Singh
Huntington's disease (HD) is an inherited neurodegenerative disease. 3-Nitropropionic acid (3-NP) causes increased reactive oxygen species production and neuroinflammation. Centella asiatica (CA) is a strong antioxidant. The aim of this study is to investigate the effect of hydroalcoholic extract of C. asiatica (HA-CA) on 3-NP-induced HD in adult zebrafish. Adult zebrafish (∼5–6 months old) weighing
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Astragalus Polysaccharide Alleviates Constipation in the Elderly Via Modification of Gut Microbiota and Fecal Metabolism Rejuvenation Res. (IF 2.6) Pub Date : 2022-12-12 Xiaojie Liu, Mengyu Li, Chen Jian, Fuxiao Wei, Huanle Liu, Ke Li, Xuemei Qin
Constipation is one of the most common gastrointestinal disorders, whose incidence increasing with age. As one of the main components, Astragalus polysaccharide (APS) has been used to treat a variety of diseases. This study aimed to explore the effects of APS on the improvement of gastrointestinal functions and learning memory in elderly rats with constipation. In this study, both 16S rRNA sequencing-based
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Restoration of Lysosomal and Mitochondrial Function Through p38 Mitogen-Activated Protein Kinase Inhibition Ameliorates Senescence Rejuvenation Res. (IF 2.6) Pub Date : 2022-12-12 Ji Yun Park, Haneur Lee, Eun Seon Song, Yun Haeng Lee, Myeong Uk Kuk, Gahyun Ko, Hyung Wook Kwon, Youngjoo Byun, Joon Tae Park
Oncogene-induced senescence (OIS), characterized by irreversible cell cycle arrest by oncogene activation, plays an important role in the pathogenesis of aging and age-related diseases. Recent research indicates that OIS is driven by activation of mitogen-activated protein kinase (MAPK). However, it is not apparent whether MAPK inhibition helps to recover senescence. In our previous study, we uncovered
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DNA Repair Activation and Cell Death Suppression by Plant Polyphenols in Keratinocytes Exposed to Ultraviolet Irradiation Rejuvenation Res. (IF 2.6) Pub Date : 2022-12-06 Alla I. Potapovich, Tatyana V. Kostyuk, Tatyana V. Shman, Tatyana I. Ermilova, Tatyana G. Shutava, Vladimir A. Kostyuk
This work investigated effects of plant polyphenolic compounds (PPs) on responses of cultured human HaCaT keratinocytes to ultraviolet radiation in the C range (UV-C). The experimental data obtained indicate a cytoprotective effect of PPs added immediately after UV-C exposure. The efficiency of PPs was lowered in the following order: acacetin ≥ silybin > quercetin. The influence of PPs on phosphorylation
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Downregulation of SOX21-AS1 Alleviated Cisplatin Resistance in Cervical Cancer Through Epithelial–Mesenchymal Transition Inhibition Rejuvenation Res. (IF 2.6) Pub Date : 2022-10-13 Jing Tian, Ze Li, Yuanyuan Jiang, Wenjin Gu, Enqi Kong, Quan Hao, Beihua Kong, Li Sun
Cisplatin is widely used in chemotherapies in cervical cancer (CC). Nevertheless, drug resistance in cancer patients poses a major threat to efficacy of treatment. To explore the underlying modulatory mechanism of SOX21-AS1 in cisplatin resistance in CC cell and mice models, Gepia database was referred for SOX21-AS1 expression in cancer tissues and normal ones. Reverse transcription quantitative real-time
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Berberine Ameliorates Lipopolysaccharide-Induced Cognitive Impairment Through SIRT1/NRF2/NF-κB Signaling Pathway in C57BL/6J Mice Rejuvenation Res. (IF 2.6) Pub Date : 2022-10-13 Nan Chen, Xin-Chen Wang, Ling-Ling Fan, Yu-Huang Zhu, Qi Wang, Yun-Bo Chen
The inflammatory response is the stress reactions to infection or injury so as to help the body return to normal as soon as possible. In central nervous system, the overactivated immune system causes irreversible damage to neurons and synapses, which results in cognitive impairment. Berberine, an isoquinoline alkaloid extracted from Coptidis Rhizoma, plays a powerful role in anti-inflammation. It has
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Mechanism of Thymus Rejuvenation in Elderly Macaques Rejuvenation Res. (IF 2.6) Pub Date : 2022-10-13 Yan-Ying Wang, Le Chang, Gao-Hong Zhu, Gong-Hua Li, Qing-Peng Kong, Long-Bao Lv, Qiang Wang, Chuan Tian, Ye Li, Xiang-Qing Zhu, Xing-Hua Pan
Senile thymus atrophy is an important factor leading to decreased immune function. Repairing the atrophic thymus tissue structure, rebuilding immune function, and replenishing the number of exogenous stem cells may be ideal methods. In this study, bone marrow mesenchymal stem cells were intravenously infused into elderly macaques. We found that thymus volume was substantially increased, some thymus
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Cellular and Mitochondrial Quality Control Mechanisms in Maintaining Homeostasis in Aging Rejuvenation Res. (IF 2.6) Pub Date : 2022-10-13 Urvashi Langeh, Vishal Kumar, Anoop Kumar, Pradeep Kumar, Charan Singh, Arti Singh
Aging is a natural process in all living organisms defined as destruction of cell function as a result of long-term accumulation of damages. Autophagy is a cellular house safeguard pathway that is responsible for degrading damaged cellular organelles. Moreover, it maintains cellular homeostasis, controls lifetime and longevity. Damaged mitochondrial accumulation is a characteristic of aging that is
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Link Between Senescence and Cell Fate: Senescence-Associated Secretory Phenotype and Its Effects on Stem Cell Fate Transition Rejuvenation Res. (IF 2.6) Pub Date : 2022-08-12 Yu Pan, ZhenZhen Gu, Yansi Lyu, Yi Yang, Manhon Chung, Xiaohua Pan, Sa Cai
Senescence is a form of durable cell cycle arrest elicited in response to a wide range of stimuli. Senescent cells remain metabolically active and secrete a variety of factors collectively termed senescence-associated secretory phenotype (SASP). SASP is highly pleiotropic and can impact numerous biological processes in which it has both beneficial and deleterious roles. The underlying mechanisms by
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The Effect of Progressive Resistance Training on Functionality and Handgrip Strength in the Older Individuals of a Community: A Quasi-Experimental Study Rejuvenation Res. (IF 2.6) Pub Date : 2022-08-12 Luiz Sinésio Silva Neto, Claudio Avelino dos Santos, Andreia Travassos, Andreia Bruno Figueiredo, Daniella Pires Nunes, Thiago dos Santos Rosa, Fabricio Cavalcante Frauzino, Wesquisley Vidal de Santana, Luís Fernando Sesti, Genildo Ferreira Nunes, Emerson Moura Ribeiro, Neila Barbosa Osório
Muscle weakness is associated with negative outcomes, in addition to being related to the pathogenesis of frailty and functional disability in the older individuals. Muscle strength and functionality are considered biomarkers of aging. Progressive resistance training (PRT) is a type of training that has been the subject of studies as it presents itself as a therapeutic option to fight the reduction
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Aqueous Extract from Astragalus membranaceus Can Improve the Function Degradation and Delay Aging on Drosophila melanogaster Through Antioxidant Mechanism Rejuvenation Res. (IF 2.6) Pub Date : 2022-08-12 Jianqin Zhang, Yuqi Qiao, Daqi Li, Shenghui Hao, Fusheng Zhang, Xubo Zhang, Aiping Li, Xuemei Qin
Astragali Radix is the dry root of the leguminous plants Astragalus membranaceus (Fisch.) Bge. Var. mongholicus (Bge.) Hsiao and A. membranaceus (Fisch.) Bge. Astragali Radix is mostly used clinically as a decoction. A number of pharmacological studies show that Astragalus extract can increase telomerase activity and has antioxidation, anti-inflammatory, immune regulation, anticancer, lowering blood
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Three Month Heterochronic Parabiosis Has a Deleterious Effect on the Lifespan of Young Animals, Without a Positive Effect for Old Animals Rejuvenation Res. (IF 2.6) Pub Date : 2022-08-12 Tatiana Yankova, Tatiana Dubiley, Dmytro Shytikov, Iryna Pishel
Our previous study showed that an exchange of blood between heterochronic parabionts for 3 months did not rejuvenate the immune system of the old partners. Moreover, the young immune system became more aged and began to function according to the “old” principle. Does this forced aging affect all systems of the organism in this model? We checked the levels of corticosterone, testosterone, insulin-like
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Physical Condition and Risk of Hospitalization and Polypharmacy in Older Adults Rejuvenation Res. (IF 2.6) Pub Date : 2022-08-12 Ana Fernández-Araque, Laura García-de-Diego, María Martínez-Ferrán, Ignacio Diez-Vega, Thomas Yvert, Maria Teresa Mingo-Gómez, Catalina Santiago, Helios Pareja-Galeano, Zoraida Verde
Hospitalization in older population leads to a decline in physical function, physical condition, and independency. However, a scarce number of studies has addressed the effect of being in good physical condition on the risk of hospitalization and polypharmacy in older people. Therefore, this study aims to examine the relationship between physical condition and other health factors, and the incidence
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Hormetic Effect of 3-Bromopyruvate on Age-Induced Alterations in Erythrocyte Membrane Transporters and Oxidative Biomarkers in Rats Rejuvenation Res. (IF 2.6) Pub Date : 2022-06-15 Jitendra Kumar Arya, Raushan Kumar, Shambhoo Sharan Tripathi, Syed Ibrahim Rizvi
3-Bromopyruvate (3-BP) is a glycolytic inhibitor and a potential calorie restriction mimic that shows a variety of beneficial effects in several aging model systems. A chronic low dose of 3-BP was given to male Wistar rats for 4 weeks. The effect of 3-BP on age-dependent alteration on the activities of various transporters/exchangers and redox biomarkers (protein carbonyl [PC], sialic acid [SA], sulfhydryl
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COVID-19 as a Paradigmatic Model of the Heterogeneous Disease Presentation in Older People: Data from the GeroCovid Observational Study Rejuvenation Res. (IF 2.6) Pub Date : 2022-06-15 Caterina Trevisan, Francesca Remelli, Stefano Fumagalli, Enrico Mossello, Chukwuma Okoye, Giuseppe Bellelli, Alessandra Coin, Alba Malara, Pietro Gareri, Fabio Monzani, Susanna Del Signore, Gianluca Zia, Raffaele Antonelli Incalzi, Stefano Volpato
COVID-19 may have a heterogeneous onset, especially in older age. However, whether and how COVID-19 signs and symptoms may present and aggregate together according to sociodemographic and health factors is unclear, as well as their prognostic value. This study included 981 COVID-19 inpatients who participated in the GeroCovid Observational study. Signs/symptoms at disease onset, sociodemographic, health
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Plasma Proteomic Signature of Cellular Senescence and Markers of Biological Aging Among Postmenopausal Women Rejuvenation Res. (IF 2.6) Pub Date : 2022-06-15 Ji-Won Shin, Eunil Lee, Seungbong Han, Seung-Ah Choe, Ok Hee Jeon
We aimed to investigate the association of circulatory senescence-associated secretory phenotypes (SASPs) produced by senescent cells with chronological and menopausal age in women aged 45 years or more. The proteomic profiles for 32 SASP factors of plasma samples were measured in 76 healthy postmenopausal women aged 46–82 years from the Korean Genome and Epidemiology Study Cardiovascular Disease Association
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Dietary Restriction Attenuates Inflammation and Protects Mouse Skin from High-Dose Ultraviolet B Irradiation Rejuvenation Res. (IF 2.6) Pub Date : 2022-06-15 Duozhuang Tang, Jianying Wu, Yiting Wang, Hui Cui, Zhendong Tao, Lang Lei, Zhuangfa Zhou, Si Tao
Ultraviolet B (UVB) radiation may influence the occurrence or even worsen cutaneous disorders from inflammatory to neoplastic disorders. Dietary restriction (DR) is a well-known regimen that can retard aging-associated pathologies, and is shown by us and others that it can significantly inhibit inflammation under various conditions, including in both undisturbed and stressed settings. It is unknown
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Leveraging Substrate Stiffness to Promote Stem Cell Asymmetric Division via Mechanotransduction–Polarity Protein Axis and Its Bayesian Regression Analysis Rejuvenation Res. (IF 2.6) Pub Date : 2022-04-19 Ankita Das, Shreya Adhikary, Amit Roy Chowdhury, Ananya Barui
Asymmetric division of stem cells is an evolutionarily conserved process in multicellular organisms responsible for maintaining cellular fate diversity. Symmetric–asymmetric division pattern of mesenchymal stem cells (MSCs) is regulated by both biochemical and biophysical cues. However, modulation of mechanotransduction pathway by varying scaffold properties and their adaptation to control stem cell
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Baicalein May Act as a Caloric Restriction Mimetic Candidate to Improve the Antioxidant Profile in a Natural Rodent Model of Aging Rejuvenation Res. (IF 2.6) Pub Date : 2022-04-19 Shambhoo Sharan Tripathi, Raushan Kumar, Akalabya Bissoyi, Syed Ibrahim Rizvi
Caloric restriction (CR) is the most effective intervention for extending the life span of vertebrate and invertebrate aging models. Calorie restriction mimetics (CRMs), which are synthetic or natural chemicals that mimic the biochemical, hormonal, and physiological consequences of calorie restriction, are being researched for antiaging benefits. Baicalein is a plant-derived polyphenol that has the
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Carnosine Improves Cognitive Impairment Through Promoting SIRT6 Expression and Inhibiting Endoplasmic Reticulum Stress in a Diabetic Encephalopathy Model Rejuvenation Res. (IF 2.6) Pub Date : 2022-04-19 Dong Peng, Qing Xia, Li Guan, Hong-Ying Li, Li-Jun Qiao, Yun-Bo Chen, Ye-Feng Cai, Qi Wang, Shi-Jie Zhang
Diabetic encephalopathy (DE) is one of complications of diabetes mellitus. Carnosine is a dipeptide composed of β-alanine and l-histidine. Study has shown that carnosine could ameliorate cognitive impairment in animal model with diabetes mellitus. However, the mechanism remains unclear. An animal model of type 2 diabetes (db/db mice) was used in this study. The animals were treated with 0.9% saline
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Different Expression of Micro-RNA in the Subcutaneous and Visceral Adipose Tissue of Obese Subjects Rejuvenation Res. (IF 2.6) Pub Date : 2022-04-19 Donato Lacedonia, Nicola Tartaglia, Giulia Scioscia, Piera Soccio, Giovanna Pavone, Giorgia Moriondo, Crescenzio Gallo, Maria Pia Foschino Barbaro, Antonio Ambrosi
Obesity is a pathology characterized by an excessive accumulation of adipose tissue and it is a condition associated with complex alterations affecting different organs and systems. Obesity has great influences on cardiovascular and respiratory morbidity and mortality, and impairs the multiple aspects of metabolism. Since micro-RNAs (miRNAs) are thought to play a role in the regulation of various pathological
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Mechanisms and Minimization of False Discovery of Metabolic Bioorthogonal Noncanonical Amino Acid Proteomics Rejuvenation Res. (IF 2.6) Pub Date : 2022-04-19 Chao Liu, Nathan Wong, Etsuko Watanabe, William Hou, Leonardo Biral, Jonalyn DeCastro, Melod Mehdipour, Kiana Aran, Michael J. Conboy, Irina M. Conboy
Metabolic proteomics has been widely used to characterize dynamic protein networks in many areas of biomedicine, including in the arena of tissue aging and rejuvenation. Bioorthogonal noncanonical amino acid tagging (BONCAT) is based on mutant methionine-tRNA synthases (MetRS) that incorporates metabolic tags, for example, azidonorleucine [ANL], into newly synthesized proteins. BONCAT revolutionizes
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It Is Time to Work on the Extension of Body Growth and Reproductive Stages Rejuvenation Res. (IF 2.6) Pub Date : 2022-04-19 Weikuan Gu
There are three major changes for the human lifespan in the past half decade: the decreased age of sexual maturity, slight increase in age of menopause/andropause, and a trend of increase in life expectancy. The ages of puberty and menopause are the transitions in life stages, such that early puberty leads to loss and late menopause leads to gain in the lifespan. So far, the strategies for increased
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On the Road to More Effective Rejuvenation Research. Rejuvenation Res. (IF 2.6) Pub Date : 2022-04-01 Irina Conboy
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Why Political Action Matters for the Rejuvenation Biotech Community Rejuvenation Res. (IF 2.6) Pub Date : 2022-03-24 Mr. Dylan James Venezia Livingston
The hallmark sign of a mature industry is representation in politics and government. Advocates encourage elected officials to pass beneficial laws for an industry and maybe more importantly, they defend the industry's reputation if things go awry. Technology centered around extending healthy human lifespan is set to explode over the next decade and the industry must have a unified presence in Washington
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Antiaging Vaccines Targeting Senescent Cells Rejuvenation Res. (IF 2.6) Pub Date : 2022-02-15 Andrew R. Mendelsohn, James W. Larrick
The development of senomorphic drugs to attenuate the senescent phenotype and senolytics to clear pro-inflammatory senescent cells (SCs) to treat aging-associated disorders is being hotly pursued. The effort is complicated by the fact that SCs play a constructive role in some cellular processes such as tissue repair and wound healing. However, concerns about efficacy, which SCs to target, and unwanted
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Protective Efficacy of Spilanthes acmella Murr. Extracts and Bioactive Constituents in Neuronal Cell Death Rejuvenation Res. (IF 2.6) Pub Date : 2022-02-15 Wilasinee Suwanjang, Chayanit Sirisuwat, Sujittra Srisung, Chartchalerm Isarankura-Na-Ayudhya, Supitcha Pannengpetch, Supaluk Prachayasittikul
Spilanthes acmella Murr., a well-known Thai traditional medicine, has been used for treatment of toothache, rheumatism, and fever. Diverse pharmacological activities of S. acmella Murr. have been reported. In this study, antioxidative and neuroprotective effects of S. acmella Murr. extracts as well as bioactive scopoletin, vanillic acid, and trans-ferulic acid found in the aerial parts of this plant
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Correlation Between Telomere Length and Biomarkers of Oxidative Stress in Human Aging Rejuvenation Res. (IF 2.6) Pub Date : 2022-02-15 Somu Yadav, Pawan Kumar Maurya
The telomere length (TL) has increasingly been used as a biomarker of human aging because it has been shown to predict the chances of survival and longevity. Oxidative stress is presumed to be a major cause of telomere shortening, but the importance of oxidative stress as a determinant of telomere shortening remains less clear and has recently been questioned. We analyzed 105 healthy subjects of both
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Angiotensin II-Induced Erythrocyte Senescence Contributes to Oxidative Stress Rejuvenation Res. (IF 2.6) Pub Date : 2022-02-15 Chenglin Huang, Jing Gao, Tong Wei, Weili Shen
Oxidative stress may be an important cause of erythrocyte senescence. Angiotensin II (Ang II) has recently been shown to promote vascular cell senescence. However, its effects on erythrocytes remain unclear. This study aims at investigating the role of Ang II in regulating erythrocyte lifespan through oxidative stress. Experiments were performed in C57/BL6J mice infused with Ang II (1500 ng/kg per