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A 3-Layered Bioartificial Blood Vessel with Physiological Wall Architecture Generated by Mechanical Stimulation Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-22 Florian Helms, Skadi Lau, Thomas Aper, Sarah Zippusch, Melanie Klingenberg, Axel Haverich, Mathias Wilhelmi, Ulrike Böer
The generation of cellularized bioartificial blood vessels resembling all three layers of the natural vessel wall with physiological morphology and cell alignment is a long pursued goal in vascular tissue engineering. Simultaneous culture of all three layers under physiological mechanical conditions requires highly sophisticated perfusion techniques and still today remains a key challenge. Here, three-layered
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Machine-Learning Provides Patient-Specific Prediction of Metastatic Risk Based on Innovative, Mechanobiology Assay Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-22 Rakefet Rozen, Daphne Weihs
Cancer mortality is mostly related to metastasis. Metastasis is currently prognosed via histopathology, disease-statistics, or genetics; those are potentially inaccurate, not rapidly available and require known markers. We had developed a rapid (~ 2 h) mechanobiology-based approach to provide early prognosis of the clinical likelihood for metastasis. Specifically, invasive cell-subsets seeded on impenetrable
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Is the 0.2%-Strain-Offset Approach Appropriate for Calculating the Yield Stress of Cortical Bone? Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-21 Guanjun Zhang, Junjie Luo, Gang Zheng, Zhonghao Bai, Libo Cao, Haojie Mao
The 0.2% strain offset approach is mostly used to calculate the yield stress and serves as an efficient method for cross-lab comparisons of measured material properties. However, it is difficult to accurately determine the yield of the bone. Especially when computational models require accurate material parameters, clarification of the yield point is needed. We tested 24 cortical specimens harvested
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Ranking and Rating Bicycle Helmet Safety Performance in Oblique Impacts Using Eight Different Brain Injury Models Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-21 Madelen Fahlstedt, Fady Abayazid, Matthew B. Panzer, Antonia Trotta, Wei Zhao, Mazdak Ghajari, Michael D. Gilchrist, Songbai Ji, Svein Kleiven, Xiaogai Li, Aisling Ní Annaidh, Peter Halldin
Bicycle helmets are shown to offer protection against head injuries. Rating methods and test standards are used to evaluate different helmet designs and safety performance. Both strain-based injury criteria obtained from finite element brain injury models and metrics derived from global kinematic responses can be used to evaluate helmet safety performance. Little is known about how different injury
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Electric Field Stimulation for the Functional Assessment of Isolated Dorsal Root Ganglion Neuron Excitability Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-21 Ian M. Berke, Tom M. McGrath, J. Jordan Stivers, Chang Gui, Marcos N. Barcellona, Matthew G. Gayoso, Simon Y. Tang, Yu-Qing Cao, Munish C. Gupta, Lori A. Setton
Genetically encoded calcium indicators have proven useful for characterizing dorsal root ganglion neuron excitability in vivo. Challenges persist in achieving high spatial–temporal resolutions in vivo, however, due to deep tissue imaging and motion artifacts that may be limiting technical factors in obtaining measurements. Here we report an ex vivo imaging method, using a peripheral neuron-specific
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Antifriction Mechanism of Longitudinal Vibration-Assisted Insertion in DBS Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-21 Wenhao Wu, Jun Zhou, Panling Huang, Chunyang Pan, Zhixiang Huang, Changfeng Xu
Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease. The insertion of brain tissue is an important procedure that affects the whole operation and the sequela. During the insertion process, the friction between the tissue and the needle shaft is the main factor affecting the degree of tissue damage and the accuracy of target location. Vibration-assisted needle insertion has
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An Evolving Clinical Need: Discordant Oxygenation Measurements of Intubated COVID-19 Patients Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-19 Jerry A. Rubano, Lauren M. Maloney, Jessica Simon, Daniel N. Rutigliano, Isadora Botwinick, Randeep S. Jawa, Marc J. Shapiro, James A. Vosswinkel, Mark Talamini, Kenneth Kaushansky
Since the first appearance of the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) earlier this year, clinicians and researchers alike have been faced with dynamic, daily challenges of recognizing, understanding, and treating the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2. Those who are moderately to severely ill with COVID-19 are likely to develop acute hypoxemic respiratory
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Two Magnetic Sensor Based Real-Time Tracking of Magnetically Inflated Swallowable Intragastric Balloon Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-15 Muneaki Miyasaka, Anthony Meng Huat Tiong, Phuoc Thien Phan, Yanpei Huang, Hung Leng Kaan, Khek Yu Ho, Soo Jay Phee
This paper presents a two magnetic sensor based tracking method for a magnetically inflated intragastric balloon capsule (MIBC) which is used for obesity treatment. After the MIBC is swallowed, it is designed to be inflated inside the stomach by approaching a permanent magnet (PM) externally near the abdomen. However, if the balloon inflation is accidentally triggered while the MIBC is still in the
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Review of Wearable and Portable Sensors for Monitoring Personal Solar UV Exposure Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-11 Xiyong Huang, Andrew N. Chalmers
Sunlight is one of the main environmental resources that keeps all the organisms alive on earth. The ultraviolet (UV) radiation from the sun is essential for vitamin D synthesis in the human body, which is crucial for bone and muscle health. In addition, sun exposure also helps to reduce the risk of some cardiovascular diseases and cancers. However, excessive UV exposure can lead to adverse effects
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Forces Involved with Labor and Delivery—A Biomechanical Perspective Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-11 Michele J. Grimm
Childbirth is a primarily biomechanical process of physiology, and one that engineers have recently begun to address in a broader fashion. Computational models are being developed to address the biomechanical effects of parturition on both maternal and fetal tissues. Experimental research is being conducted to understand how maternal tissues adapt to intrauterine forces near the onset of labor. All
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Bioengineering Approaches for Placental Research Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-08 Mackenzie L. Wheeler, Michelle L. Oyen
Research into the human placenta’s complex functioning is complicated by a lack of suitable physiological in vivo models. Two complementary approaches have emerged recently to address these gaps in understanding, computational in silico techniques, including multi-scale modeling of placental blood flow and oxygen transport, and cellular in vitro approaches, including organoids, tissue engineering,
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Is Experience in Hemodialysis Cannulation Related to Expertise? A Metrics-based Investigation for Skills Assessment Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-08 Zhanhe Liu, Ziyang Zhang, Deborah Kunkel, Prabir Roy-Chaudhury, Ravikiran Singapogu
Cannulation is not only one of the most common medical procedures but also fraught with complications. The skill of the clinician performing cannulation directly impacts cannulation outcomes. However, current methods of teaching this skill are deficient, relying on subjective demonstrations and unrealistic manikins that have limited utility for skills training. Furthermore, of the factors that hinders
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From Transcript to Tissue: Multiscale Modeling from Cell Signaling to Matrix Remodeling Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-07 Linda Irons, Marcos Latorre, Jay D. Humphrey
Tissue-level biomechanical properties and function derive from underlying cell signaling, which regulates mass deposition, organization, and removal. Here, we couple two existing modeling frameworks to capture associated multiscale interactions—one for vessel-level growth and remodeling and one for cell-level signaling—and illustrate utility by simulating aortic remodeling. At the vessel level, we
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Liquid Poly-N-acetyl Glucosamine (sNAG) Improves Achilles Tendon Healing in a Rat Model Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-06 Courtney A. Nuss, Julianne Huegel, Sergio Finkielsztein, Louis J. Soslowsky
The Achilles tendon, while the strongest and largest tendon in the body, is frequently injured. Even after surgical repair, patients risk re-rupture and long-term deficits in function. Poly-N-acetyl glucosamine (sNAG) polymer has been shown to increase the rate of healing of venous leg ulcers, and use of this material improved tendon-to-bone healing in a rat model of rotator cuff injury. Therefore
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Low-Profile Electromagnetic Field Sensors in the Measurement and Modelling of Three-Dimensional Jaw Kinematics and Occlusal Loading Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-06 Sarah C. Woodford, Dale L. Robinson, Cornelia Edelmann, Albert Mehl, Oliver Röhrle, Peter Vee Sin Lee, David C. Ackland
Dynamic occlusal loading during mastication is clinically relevant in the design and functional assessment of dental restorations and removable dentures, and in evaluating temporomandibular joint dysfunction. The aim of this study was to develop a modelling framework to evaluate subject-specific dynamic occlusal loading during chewing and biting over the entire dental arch. Measurements of jaw motion
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A Millifluidic Perfusion Cassette for Studying the Pathogenesis of Enteric Infections Using Ex-Vivo Organoids Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-06 Reid L. Wilson, Sarah A. Hewes, Anubama Rajan, Shih-Ching Lin, Carolyn Bomidi, Takanori Iida, Mary K. Estes, Anthony W. Maresso, K. Jane Grande-Allen
To generate physiologically-relevant experimental models, the study of enteric diarrheal diseases is turning increasingly to advanced in vitro models that combine ex vivo, stem cell-derived “organoid” cell lines with bioengineered culture environments that expose them to mechanical stimuli, such as fluid flow. However, such approaches require considerable technical expertise with both microfabrication
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Characterization of Chitosan-Based Scaffolds Seeded with Sheep Nasal Chondrocytes for Cartilage Tissue Engineering Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-06 Anamarija Rogina, Maja Pušić, Lucija Štefan, Alan Ivković, Inga Urlić, Marica Ivanković, Hrvoje Ivanković
The treatment of cartilage defect remains a challenging issue in clinical practice. Chitosan-based materials have been recognized as a suitable microenvironment for chondrocyte adhesion, proliferation and differentiation forming articular cartilage. The use of nasal chondrocytes to culture articular cartilage on an appropriate scaffold emerged as a promising novel strategy for cartilage regeneration
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Comparison of in Vascular Bioreactors and In Vivo Models of Degradation and Cellular Response of Mg–Zn–Mn Stents Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-06 Ningling Zhou, Ping Li, Hua Qiu, Jin Wang, Nan Huang, Ansha Zhao, Juan Wang
Traditional in vitro evaluation criteria of magnesium (Mg)-based stents cannot reflect the degradation process in vivo, due to the interdependence and interference between biodegradable properties and bioenvironment. The current direct and indirect evaluation approaches of in vitro biocompatibility do not have a hydrodynamic environment and vascular biological structure existing in vivo. Herein, we
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Microengineered 3D Tumor Models for Anti-Cancer Drug Discovery in Female-Related Cancers Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-05 Farbod Amirghasemi, Emmanuela Adjei-Sowah, Barbara A. Pockaj, Mehdi Nikkhah
The burden of cancer continues to increase in society and negatively impacts the lives of numerous patients. Due to the high cost of current treatment strategies, there is a crucial unmet need to develop inexpensive preclinical platforms to accelerate the process of anti-cancer drug discovery to improve outcomes in cancer patients, most especially in female patients. Many current methods employ expensive
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Boundary-Condition Analysis of an Idealized Left Atrium Model Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-05 Jorge Dueñas-Pamplona, José Sierra-Pallares, Javier García, Francisco Castro, Jorge Munoz-Paniagua
The most common type of cardiac arrhythmia is atrial fibrillation (AF), which is characterised by irregular and ineffective atrial contraction. This behaviour results into the formation of thrombi, mainly in the left atrial appendage (LAA), responsible for thromboembolic events. Very different approaches are considered as therapy for AF patients. Therefore, it is necessary to yield insight into the
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A Method Based on 3D Shape Analysis Towards the Design of Flexible Instruments for Endoscopic Maxillary Sinus Surgery Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-05 Julie Legrand, Kenan Niu, Zhen Qian, Kathleen Denis, Vincent Vander Poorten, Laura Van Gerven, Emmanuel Vander Poorten
The emergence of steerable flexible instruments has widened the uptake of minimally invasive surgical techniques. In sinus surgery, such flexible instruments could enable the access to difficult-to-reach anatomical areas. However, design-oriented metrics, essential for the development of steerable flexible instruments for maxillary sinus surgery, are still lacking. This paper proposes a method to process
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Automatic Respiratory Phase Identification Using Tracheal Sounds and Movements During Sleep Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-05 Nasim Montazeri Ghahjaverestan, Muammar Kabir, Shumit Saha, Kaiyin Zhu, Bojan Gavrilovic, Hisham Alshaer, Babak Taati, Azadeh Yadollahi
One of the most important signals to assess respiratory function, especially in patients with sleep apnea, is airflow. A convenient method to estimate airflow is based on analyzing tracheal sounds and movements. However, this method requires accurate identification of respiratory phases. Our goal is to develop an automatic algorithm to analyze tracheal sounds and movements to identify respiratory phases
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Regional Brain Tissue Displacement and Strain is Elevated in Subjects with Chiari Malformation Type I Compared to Healthy Controls: A Study Using DENSE MRI Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-04 Blaise Simplice Talla Nwotchouang, Maggie S. Eppelheimer, Soroush Heidari Pahlavian, Jack W. Barrow, Daniel L. Barrow, Deqiang Qiu, Philip A. Allen, John N. Oshinski, Rouzbeh Amini, Francis Loth
While the degree of cerebellar tonsillar descent is considered the primary radiologic marker of Chiari malformation type I (CMI), biomechanical forces acting on the brain tissue in CMI subjects are less studied and poorly understood. In this study, regional brain tissue displacement and principal strains in 43 CMI subjects and 25 controls were quantified using a magnetic resonance imaging (MRI) methodology
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Longitudinal Evolution of Pulmonary Artery Wall Shear Stress in a Swine Model of Pulmonary Artery Stenosis and Stent Interventions Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-04 Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-Alzate
Branch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and it has previously been hypothesized that in branch PAS the pulmonary arteries (PAs) remodel their lumen diameter to maintain constant wall shear stress (WSS). We quantified the longitudinal progression of PA WSS in a swine model of unilateral PAS and two different intervention time courses to test this hypothesis
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Finite Element Simulations of the ID Venous System to Treat Venous Compression Disorders: From Model Validation to Realistic Implant Prediction Ann. Biomed. Eng. (IF 3.324) Pub Date : 2021-01-04 Alissa Zaccaria, Francesco Migliavacca, David Contassot, Frederic Heim, Nabil Chakfe, Giancarlo Pennati, Lorenza Petrini
The ID Venous System is an innovative device proposed by ID NEST MEDICAL to treat venous compression disorders that involve bifurcations, such as the May-Thurner syndrome. The system consists of two components, ID Cav and ID Branch, combined through a specific connection that prevents the migration acting locally on the pathological region, thereby preserving the surrounding healthy tissues. Preliminary
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Myocardial Perfusion Simulation for Coronary Artery Disease: A Coupled Patient-Specific Multiscale Model Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-12-01 Lazaros Papamanolis, Hyun Jin Kim, Clara Jaquet, Matthew Sinclair, Michiel Schaap, Ibrahim Danad, Pepijn van Diemen, Paul Knaapen, Laurent Najman, Hugues Talbot, Charles A. Taylor, Irene Vignon-Clementel
Patient-specific models of blood flow are being used clinically to diagnose and plan treatment for coronary artery disease. A remaining challenge is bridging scales from flow in arteries to the micro-circulation supplying the myocardium. Previously proposed models are descriptive rather than predictive and have not been applied to human data. The goal here is to develop a multiscale patient-specific
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In Silico Ventilation Within the Dose-Volume is Predictive of Lung Function Post-radiation Therapy in Patients with Lung Cancer Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-30 Yu Dong, H. Kumar, M. Tawhai, C. Veiga, A. Szmul, D. Landau, J. McClelland, L. Lao, K. S. Burrowes
Lung cancer is a leading cause of death worldwide. Radiation therapy (RT) is one method to treat this disease. A common side effect of RT for lung cancer is radiation-induced lung damage (RILD) which leads to loss of lung function. RILD often compounds pre-existing smoking-related regional lung function impairment. It is difficult to predict patient outcomes due to large variability in individual response
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Brain Strain: Computational Model-Based Metrics for Head Impact Exposure and Injury Correlation Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-30 Logan E. Miller, Jillian E. Urban, Elizabeth M. Davenport, Alexander K. Powers, Christopher T. Whitlow, Joseph A. Maldjian, Joel D. Stitzel
Athletes participating in contact sports are exposed to repetitive subconcussive head impacts that may have long-term neurological consequences. To better understand these impacts and their effects, head impacts are often measured during football to characterize head impact exposure and estimate injury risk. Despite widespread use of kinematic-based metrics, it remains unclear whether any single metric
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Analyzing Liver Surface Indentation for In Vivo Refinement of Tumor Location in Minimally Invasive Surgery Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-30 Yingqiao Yang, Kai-Leung Yung, Tin Wai Robert Hung, Kai-Ming Yu
Manual palpation to update the position of subsurface tumor(s) is a normal practice in open surgery, but is not possible through the small incisions of minimally invasive surgery (MIS). This paper proposes a method that has the potential to use a simple constant-force indenter and the existing laparoscopic camera for tumor location refinement in MIS. The indenter floats with organ movement to generate
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Post-graduation Plans of Undergraduate BME Students: Gender, Self-efficacy, Value, and Identity Beliefs Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-23 Anita Patrick, Maura Borrego, Catherine Riegle-Crumb
This study investigates career intentions and students’ engineering attitudes in BME, with a focus on gender differences. Data from n = 716 undergraduate biomedical engineering students at a large public research institution in the United States were analyzed using hierarchical agglomerative cluster analysis. Results revealed five clusters of intended post-graduation plans: Engineering Job and Graduate
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An Improved Method for Developing Injury Risk Curves Using the Brier Metric Score Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-20 Zachary S. Hostetler, Fang-Chi Hsu, Narayan Yoganandan, Frank A. Pintar, Anjishnu Banerjee, Liming Voo, F. Scott Gayzik
Many injury metrics are routinely proposed from measured or derived quantities from biomechanical experiments using post mortem human subjects (PMHS). The existing literature did not provide guidance on deciding between parameters collected in an experiment that would be best to use for the development of human injury probability curves (HIPC). The objective of this study was to use the Brier Metric
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EndoPil: A Magnetically Actuated Swallowable Capsule for Weight Management: Development and Trials Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-19 Phuoc Thien Phan, Anthony Meng Huat Tiong, Muneaki Miyasaka, Lin Cao, Hung Leng Kaan, Khek Yu Ho, Soo Jay Phee
Intragastric balloons (IGBs), by occupying the stomach space and prolonging satiety, is a promising method to treat obesity and consequently improves its associated comorbidities, e.g. coronary heart disease, diabetes, and cancer. However, existing IGBs are often tethered with tubes for gas or liquid delivery or require endoscopic assistance for device delivery or removal, which are usually uncomfortable
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Neck Muscle and Head/Neck Kinematic Responses While Bracing Against the Steering Wheel During Front and Rear Impacts Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-19 Jason B. Fice, Daniel W. H. Mang, Jóna M. Ólafsdóttir, Karin Brolin, Peter A. Cripton, Jean-Sébastien Blouin, Gunter P. Siegmund
Drivers often react to an impending collision by bracing against the steering wheel. The goal of the present study was to quantify the effect of bracing on neck muscle activity and head/torso kinematics during low-speed front and rear impacts. Eleven seated subjects (3F, 8 M) experienced multiple sled impacts (Δv = 0.77 m/s; apeak = 19.9 m/s2, Δt = 65.5 ms) with their hands on the steering wheel in
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Load Distribution at the Patellofemoral Joint During Walking Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-16 Lucas T. Thomeer, Yi-Chung Lin, Marcus G. Pandy
We combined computational modelling with experimental gait data to describe and explain load distribution across the medial and lateral facets of the patella during normal walking. The body was modelled as a 13-segment, 32-degree-of-freedom (DOF) skeleton actuated by 80 muscles. The knee was represented as a 3-body, 12-DOF mechanical system with deformable articular cartilage surfaces at the tibiofemoral
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A Review of On-Field Investigations into the Biomechanics of Concussion in Football and Translation to Head Injury Mitigation Strategies Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-16 Bethany Rowson, Stefan M. Duma
This review paper summarizes the scientific advancements in the field of concussion biomechanics in American football throughout the past five decades. The focus is on-field biomechanical data collection, and the translation of that data to injury metrics and helmet evaluation. On-field data has been collected with video analysis for laboratory reconstructions or wearable head impact sensors. Concussion
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A Computationally-Efficient, Online-Learning Algorithm for Detecting High-Voltage Spindles in the Parkinsonian Rats Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-16 Ramesh Perumal, Vincent Vigneron, Chi-Fen Chuang, Yen-Chung Chang, Shih-Rung Yeh, Hsin Chen
Abnormally-synchronized, high-voltage spindles (HVSs) are associated with motor deficits in 6-hydroxydopamine-lesioned parkinsonian rats. The non-stationary, spike-and-wave HVSs (5-13 Hz) represent the cardinal parkinsonian state in the local field potentials (LFPs). Although deep brain stimulation (DBS) is an effective treatment for the Parkinson’s disease, continuous stimulation results in cognitive
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Body Anthropometry and Bone Strength Conjointly Determine the Risk of Hip Fracture in a Sideways Fall Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-12 Marco Palanca, Egon Perilli, Saulo Martelli
We hypothesize that variations of body anthropometry, conjointly with the bone strength, determine the risk of hip fracture. To test the hypothesis, we compared, in a simulated sideways fall, the hip impact energy to the energy needed to fracture the femur. Ten femurs from elderly donors were tested using a novel drop-tower protocol for replicating the hip fracture dynamics during a fall on the side
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Biomechanics of Human Fetal Hearts with Critical Aortic Stenosis Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-11 Chi Wei Ong, Meifeng Ren, Hadi Wiputra, Joy Mojumder, Wei Xuan Chan, Andreas Tulzer, Gerald Tulzer, Martin Lindsay Buist, Citra Nurfarah Zaini Mattar, Lik Chuan Lee, Choon Hwai Yap
Critical aortic stenosis (AS) of the fetal heart causes a drastic change in the cardiac biomechanical environment. Consequently, a substantial proportion of such cases will lead to a single-ventricular birth outcome. However, the biomechanics of the disease is not well understood. To address this, we performed Finite Element (FE) modelling of the healthy fetal left ventricle (LV) based on patient-specific
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Rapid CT-based Estimation of Articular Cartilage Biomechanics in the Knee Joint Without Cartilage Segmentation Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-11 Ali Mohammadi, Katariina A. H. Myller, Petri Tanska, Jukka Hirvasniemi, Simo Saarakkala, Juha Töyräs, Rami K. Korhonen, Mika E. Mononen
Knee osteoarthritis (OA) is a painful joint disease, causing disabilities in daily activities. However, there is no known cure for OA, and the best treatment strategy might be prevention. Finite element (FE) modeling has demonstrated potential for evaluating personalized risks for the progression of OA. Current FE modeling approaches use primarily magnetic resonance imaging (MRI) to construct personalized
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Mechanical Regulation of Apoptosis in the Cardiovascular System Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-09 Zachary E. Goldblatt, Heather A. Cirka, Kristen L. Billiar
Apoptosis is a highly conserved physiological process of programmed cell death which is critical for proper organism development, tissue maintenance, and overall organism homeostasis. Proper regulation of cell removal is crucial, as both excessive and reduced apoptotic rates can lead to the onset of a variety of diseases. Apoptosis can be induced in cells in response to biochemical, electrical, and
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Regenerative Potential of Mandibular Condyle Cartilage and Bone Cells Compared to Costal Cartilage Cells When Seeded in Novel Gelatin Based Hydrogels Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-05 A. R. Chin, J. M. Taboas, A. J. Almarza
The field of temporomandibular joint (TMJ) condyle regeneration is hampered by a limited understanding of the phenotype and regeneration potential of cells in mandibular condyle cartilage. It has been shown that chondrocytes derived from hyaline and costal cartilage exhibit a greater chondro-regenerative potential in vitro than those from mandibular condylar cartilage. However, our recent in vivo studies
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Chronic Nicotine Exposure Minimally Affects Rat Supraspinatus Tendon Properties and Bone Microstructure Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-03 Julianne Huegel, Courtney A. Nuss, Peter Y. W. Chan, Adnan N. Cheema, Andrew F. Kuntz, Louis J. Soslowsky
Cigarette smoking is the largest cause of preventable deaths, and a known risk factor for musculoskeletal issues including rotator cuff tendon tears. Tendon degeneration is believed to be due in part to changes in tendon cell health and collagen structure. Several studies have demonstrated that exposure to nicotine negatively impacts tendon healing, but surprisingly, nicotine exposure was shown to
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Actin as a Target to Reduce Cell Invasiveness in Initial Stages of Metastasis Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-03 Martha B. Alvarez-Elizondo, Yulia Merkher, Gal Shleifer, Carmel Gashri, Daphne Weihs
We demonstrate the relative roles of the cell cytoskeleton, and specific importance of actin in facilitating mechanical aspects of metastatic invasion. A crucial step in metastasis, the typically lethal spread of cancer to distant body-sites, is cell invasion through dense tissues composed of extracellular matrix and various non-cancerous cells. Cell invasion requires cell-cytoskeleton remodeling to
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Effect of Left and Right Coronary Flow Waveforms on Aortic Sinus Hemodynamics and Leaflet Shear Stress: Correlation with Calcification Locations Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-03 Dorma C. Flemister, Hoda Hatoum, Varshini Guhan, Banafsheh Zebhi, Joy Lincoln, Juan Crestanello, Lakshmi P. Dasi
Coronary flow induces hemodynamic alterations in the aortic sinus region. The objectives of this study are to: (1) investigate the differences among sinus hemodynamics and leaflet wall shear stresses engendered by the left versus right versus non-coronary flow and (2) correlate respective wall shear stresses with leaflet calcification in patients. A left heart simulator flow loop with a tunable coronary
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Abrupt Deterioration of COVID-19 Patients and Spreading of SARS COV-2 Virions in the Lungs Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-02 N. Filipovic, I. Saveljic, K. Hamada, A. Tsuda
A unique feature of COVID-19 interstitial pneumonia is an abrupt progression to respiratory failure. Our calculation shows that this abrupt deteriorate may be caused by a sudden shift in the spread of virus-laden bioaerosols through the airways to many different regions of the lungs from the initial site of infection.
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Recent Developments in Prosthesis Sensors, Texture Recognition, and Sensory Stimulation for Upper Limb Prostheses Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-02 Andrew Masteller, Sriramana Sankar, Han Biehn Kim, Keqin Ding, Xiaogang Liu, Angelo H. All
Current developments being made in upper limb prostheses are focused on replacing lost sensory information to the amputees. Providing sensory stimulation from the prosthesis can directly improve control over the prosthetic and provide a sense of body ownership. The focus of this review article is on recent developments while including foundational knowledge for some of the critical concepts in neural
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Do Head Injury Biomechanics Predict Concussion Clinical Recovery in College American Football Players? Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-11-02 Jason P. Mihalik, Avinash Chandran, Jacob R. Powell, Patricia R. Roby, Kevin M. Guskiewicz, Brian D. Stemper, Alok S. Shah, Steven Rowson, Stefan Duma, Jaroslaw Harezlak, Larry Riggen, Steven P. Broglio, Thomas W. McAllister, Michael McCrea
Identifying the associations between head impact biomechanics and clinical recovery may inform better head impact monitoring procedures and identify athletes who may benefit from early treatments aimed to enhance recovery. The purpose of this study was to test whether head injury biomechanics are associated with clinical recovery of symptom severity, balance, and mental status, as well as symptom resolution
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HFUS Imaging of the Cochlea: A Feasibility Study for Anatomical Identification by Registration with MicroCT Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-30 Lucas Lavenir, Nabil Zemiti, Mohamed Akkari, Gérard Subsol, Frédéric Venail, Philippe Poignet
Cochlear implantation consists in electrically stimulating the auditory nerve by inserting an electrode array inside the cochlea, a bony structure of the inner ear. In the absence of any visual feedback, the insertion results in many cases of damages of the internal structures. This paper presents a feasibility study on intraoperative imaging and identification of cochlear structures with high-frequency
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In Vitro Investigation of the Effect of Left Ventricular Assist Device Speed and Pulsatility Mode on Intraventricular Hemodynamics Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-30 Fanette Chassagne, Marissa Miramontes, Venkat Keshav Chivukula, Song Li, Jennifer A. Beckman, Claudius Mahr, Alberto Aliseda
Stroke has become the main cause of mortality and morbidity in patients treated with Left Ventricular Assist Devices (LVADs). The hemodynamics of the left ventricle are altered by the implantation of an LVAD, with the increase of thrombogenic flow patterns, such as stagnation regions. Time-resolved stereo particle image velocimetry (Stereo-PIV) measurements of the flow inside a patient-specific model
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Tendon Multiscale Structure, Mechanics, and Damage Are Affected by Osmolarity of Bath Solution Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-30 Ellen T. Bloom, Andrea H. Lee, Dawn M. Elliott
One of the most common bath solutions used in musculoskeletal mechanical testing is phosphate buffered saline (PBS). In tendon, swelling induced by physiological PBS results in decreased tendon modulus and induces microstructural changes. It is critical to evaluate the multiscale mechanical behavior of tendon under swelling to interpret prior work and provide information to design future studies. We
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Multimodal Loading Environment Predicts Bioresorbable Vascular Scaffolds’ Durability Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-29 Pei-Jiang Wang, Francesca Berti, Luca Antonini, Farhad Rikhtegar Nezami, Lorenza Petrini, Francesco Migliavacca, Elazer R. Edelman
Bioresorbable vascular scaffolds were considered the fourth generation of endovascular implants deemed to revolutionize cardiovascular interventions. Yet, unexpected high risk of scaffold thrombosis and post-procedural myocardial infractions quenched the early enthusiasm and highlighted the gap between benchtop predictions and clinical observations. To better understand scaffold behavior in the mechanical
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3D Analysis of the Proximal Femur Compared to 2D Analysis for Hip Fracture Risk Prediction in a Clinical Population Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-29 Fatemeh Jazinizadeh, Cheryl E. Quenneville
Due to the adverse impacts of hip fractures on patients’ lives, it is crucial to enhance the identification of people at high risk through accessible clinical techniques. Reconstructing the 3D geometry and BMD distribution of the proximal femur could be beneficial in enhancing hip fracture risk predictions; however, it is associated with a high computational burden. It is also not clear whether it
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Multi-directional Morphological Assessment of Single Bacterial Colonies Through Non-invasive Optical Imaging Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-28 Junsoo Lee, Seung-Yeol Lee, Sangyeob Han, Daewoon Seong, Ruchire Eranga Wijesinghe, Pilun Kim, Mansik Jeon, Hee-Young Jung, Jeehyun Kim
A bacterium in bacterial colony is a basal component of bacterial studies and is therefore of considerable importance. The morphological characteristics of a single colony have been widely used as the standard to identify diverse bacterial species. However, the conventional methods for obtaining morphological information, such as microscopic techniques, cannot provide tomographic views. This study
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Concussion Risk Between Individual Football Players: Survival Analysis of Recurrent Events and Non-events Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-28 Steven Rowson, Eamon T. Campolettano, Stefan M. Duma, Brian Stemper, Alok Shah, Jaroslaw Harezlak, Larry Riggen, Jason P. Mihalik, Alison Brooks, Kenneth L. Cameron, Steven J. Svoboda, Megan N. Houston, Thomas McAllister, Steven Broglio, Michael McCrea
Concussion tolerance and head impact exposure are highly variable among football players. Recent findings highlight that head impact data analyses need to be performed at the subject level. In this paper, we describe a method of characterizing concussion risk between individuals using a new survival analysis technique developed with real-world head impact data in mind. Our approach addresses the limitations
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Correction to: Trunk Reaction Time and Kinematic Changes Following Slip Perturbations in Subjects with Recurrent Low Back Pain Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-27 Paul S. Sung, Pamela Danial
This erratum is to correct the results section on page 490.
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High Energy Side and Rear American Football Head Impacts Cause Obvious Performance Decrement on Video Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-27 Adam J. Bartsch, Daniel Hedin, Jay Alberts, Edward C. Benzel, Jason Cruickshank, Robert S. Gray, Kenneth Cameron, Megan N. Houston, Tyler Rooks, Gerald McGinty, Erick Kozlowski, Steven Rowson, Joseph C. Maroon, Vincent J. Miele, J. Chris Ashton, Gunter P. Siegmund, Alok Shah, Michael McCrea, Brian Stemper
The objective of this study was to compare head impact data acquired with an impact monitoring mouthguard (IMM) to the video-observed behavior of athletes’ post-collision relative to their pre-collision behaviors. A total of n = 83 college and high school American football players wore the IMM and were video-recorded over 260 athlete-exposures. Ex-athletes and clinicians reviewed the video in a two-step
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Machine Learning Classification of Verified Head Impact Exposure Strengthens Associations with Brain Changes Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-27 Christopher A. DiCesare, Brittany Green, Weihong Yuan, Jed A. Diekfuss, Kim D. Barber Foss, Jon Dudley, Yichen Qin, Peng Wang, Gregory D. Myer
Cumulative exposure to head impacts during contact sports can elicit potentially deleterious brain white matter alterations in young athletes. Head impact exposure is commonly quantified using wearable sensors; however, these sensors tend to overestimate the number of true head impacts that occur and may obfuscate potential relationships with longitudinal brain changes. The purpose of this study was
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Mechanobiology of Bone Consolidation During Distraction Osteogenesis: Bone Lengthening Vs. Bone Transport Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-27 Pablo Blázquez-Carmona, Juan Mora-Macías, Juan Morgaz, José Andrés Fernández-Sarmiento, Jaime Domínguez, Esther Reina-Romo
Bone lengthening and bone transport are regeneration processes that commonly rely on distraction osteogenesis, a widely accepted surgical procedure to deal with numerous bony pathologies. Despite the extensive study in the literature of the influence of biomechanical factors, a lack of knowledge about their mechanobiological differences prevents a clinical particularization. Bone lengthening treatments
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In-Vitro Assessment of the Effects of Transcatheter Aortic Valve Leaflet Design on Neo-Sinus Geometry and Flow Ann. Biomed. Eng. (IF 3.324) Pub Date : 2020-10-23 Beatrice Ncho, Vahid Sadri, Jillian Ortner, Sai Kollapaneni, Ajit Yoganathan
Transcatheter aortic valve (TAV) leaflet thrombosis is a clinical risk with potentially fatal consequences. Studies have identified neo-sinus flow stasis as a cause of leaflet thrombosis. Flow stasis is influenced by the TAV leaflets, which affect the local fluid dynamics in the aortic sinus and neo-sinus. This study evaluated the effects of TAV leaflet features on the neo-sinus flow as a measure of