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Selenomethionine Inhibits NF-κB-mediated Inflammatory Responses of Bovine Mammary Epithelial Cells Caused by Klebsiella pneumoniae by Increasing Autophagic Flux Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-04-01 Siyan Xu, Yixue Miao, Junsheng Dong, Luying Cui, Kangjun Liu, Jianji Li, Xia Meng, Guoqiang Zhu, Heng Wang
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Hair Heavy Metals and Food Consumption in Residents of Chengdu: Factors, Food Contribution, and Health Risk Assessment Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-04-01 Hong-Xin Zeng, Yu Bon Man, Ming Hung Wong, Zhang Cheng
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Decreased Arsenic Disposition and Alteration of its Metabolic Profile in mice Coexposed to Fluoride Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-04-01 Luz C. Sanchez Peña, Angel Barrera Hernández, Luz M. Del Razo
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Iodine Excess May Lead to Low Exam Score in Children Aged 8–10 Years Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-04-01 Zhengyuan Wang, Chong Shao, Yaoyan Zhu, Zehuan Shi, Mengying Qu, Qi Song, Liping Shen, Shupeng Mai, Wei Lu, Zhuo Sun, Xuesong Xiang, Jiajie Zang
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Human Health Risk Assessment due to the Incidence of Heavy Metals in Different Commercial Feeds Used for the Culturing of Biofloc Fish (Nile tilapia: Oreochromis niloticus) Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-04-01 Mahvish Jabeen Channa, Huma Ayub, Javed Ahmed Ujan, Syed Sikandar Habib, Mujeeb Ullah, Sobia Attaullah, Khayyam Khayyam, Khalid Khan
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Zinc Inhibits Lead-Induced Oxidative Stress and Apoptosis of ST Cells Through ROS/PTEN/PI3K/AKT Axis Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-03-01 Haoyu Zhang, Kexin Sun, Meichen Gao, Shiwen Xu
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Testicular Toxicity in Rats Exposed to AlCl3: a Proteomics Study Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-03-01 Huixin Peng, Yanxin Huang, Guangji Wei, Yanfang Pang, Huixiong Yuan, Xiong Zou, Yu’an Xie, Wencheng Chen
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Application of Multiple Occupational Health Risk Assessment Models for Metal Fumes in Welding Process Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-03-01 Bahman Pourhassan, Zahra Beigzadeh, Nafiseh Nasirzadeh, Ali Karimi
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Ionomic Variation Among Tissues in Fallow Deer (Dama dama) by Sex and Age Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-03-01 Elke Wenting, Henk Siepel, Melanie Christerus, Patrick A. Jansen
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Therapeutic Effects of Selenium on Alpha-Synuclein Accumulation in Substantia Nigra Pars Compacta in a Rat Model of Parkinson’s Disease: Behavioral and Biochemical Outcomes Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-03-01 Sanaz Salaramoli, Hamid Reza Joshaghani, Mahmoud Hosseini, Seyed Isaac Hashemy
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Quantitative Proteomics Reveals Manganese Alleviates Heat Stress of Broiler Myocardial Cells via Regulating Nucleic Acid Metabolism Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-03-01 Shizhen Qin, Rui Wang, Jinlu Li, Defu Tang, Zhaoguo Shi
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Metal(loid)s Profile of Four Traditional Ethiopian Teff Brands: Geographic Origin Discrimination Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-03-01 Desta Woldetsadik, Douglas B Sims, Mark C. Garner, Hillette Hailu
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Editorial Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-01-19 John B. Vincent, Forrest H. Nielsen, Wen-Hsing Cheng
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Effect of Copper and Zinc Ions on Biochemical and Molecular Characteristics of Calcium Oxalate Renal Stones: a Controlled Clinical Study Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Shaimaa A. Y. Taha, Ahmed A. Shokeir, Wael I. Mortada, Amira Awadalla, Lamiaa A. A. Barakat
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Health Risk Assessment of Lead, Cadmium, and Arsenic in Leafy Vegetables in Tehran, Iran: the Concentration Data Study Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Behrouz Tajdar-oranj, Fardin Javanmardi, Karim Parastouei, Maryam Taghdir, Morteza Fathi, Sepideh Abbaszadeh
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Mechanistic Approach on the Pulmonary Oxido-Inflammatory Stress Induced by Cobalt Ferrite Nanoparticles in Rats Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Eman I. Hassanen, Rehab E. Abdelrahman, Hassan Aboul-Ella, Marwa A. Ibrahim, Samaa El-Dek, Mohamed Shaalan
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The Association Between Environmental Cadmium Exposure and Parathyroid Hormone Levels Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Hongye Tang, Jiangchuan Wang, Rongzhou Wang, Nandong Hu, Zicheng Wei, Guoying Zhu, Taiyi Jin, Xiao Chen
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The Role of Thyroid Hormone Synthesis Gene-Related miRNAs Profiling in Structural and Functional Changes of The Thyroid Gland Induced by Excess Iodine Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Chunyu Zhang, Jinyin Yao, Chang Liu, Kunying Yang, Wei Zhang, Dianjun Sun, Weikuan Gu
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Yucca schidigera Extract Mitigates the Oxidative Damages, Inflammation, and Neurochemical Impairments in the Brains of Quails Exposed to Lead Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Mayada R. Farag, Seham El-Kassas, Youssef A. Attia, Rashed A. Alhotan, Mohamed A. Mahmoud, Alessandro Di Cerbo, Mahmoud Alagawany
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Assessment and Bioaccumulation of Heavy Metals in Water, Fish (wild and Farmed) and Associated Human Health Risk Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Syed Sikandar Habib, Saira Naz, Francesco Fazio, Cristina Cravana, Mujeeb Ullah, Khalid Hussain Rind, Sobia Attaullah, Francesco Filiciotto, Khayyam Khayyam
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Metabolites in Urine that Interfere with the Sandell-Kolthoff Assay for Urinary Iodine Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Ornella Joseph, Madeline Eberle, Marya Lieberman
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Rutin, Puerarin and Silymarin Regulated Aluminum-Induced Imbalance of Neurotransmitters and Metal Elements in Brain of Rats Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2024-02-01 Jiasi Yu, Yun Ding, Dan Wu, Ping Liu
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Exploring the Complex Interplay of Trace Elements and Their Association with the Risk of Development of Pre-eclampsia in Pregnancy: a Case-Control Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-30 Kusuma Kumari Pyla, Vasundhara Devi Ilaka, Poornima Penmetsa, PVSN Kiran Kumar, Surya Prabha Yerramilli
Pre-eclampsia, a hypertensive disorder occurring during pregnancy, poses significant risks to maternal and fetal health worldwide. Despite extensive research, the precise cause of pre-eclampsia remains unknown. Recent studies have indicated that trace elements, essential minerals crucial for various biological processes, might be significant factors in the development of pre-eclampsia. This study examines
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Quercetin Supplementation Alleviates Cadmium Induced Genotoxicity-Mediated Apoptosis in Caprine Testicular Cells Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-30
Abstract Being a common environmental pollutant, cadmium causes detrimental health effects, including testicular injury. Herein, we document the ameliorative potential of quercetin, a potent antioxidant, against cadmium-induced geno-cytotoxicity and steroidogenic toxicity in goat testicular tissue. Cadmium induced different comet types (Type 0 – Type 4), indicating the varying degree of DNA-damage
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Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-30 Xiang Meng, Xiumei Meng, Zeju He, Ye Yuan, Yong Fan, Li Yin, Yu Tong, Zheping Hong, Senbo Zhu, Qiong Zhang, Qing Bi
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Association Between the Serum Copper Levels and Environmental Tobacco Exposure on the Risk of Overweight and Obesity in Children: a Study Based on the National Health and Nutrition Examination Survey Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-29
Abstract This study was to assess the individual effects of serum copper levels and environmental tobacco exposure and their joint effects on the risk of overweight and obesity among children and adolescents of 6 to 19 year olds. We analyzed cross-sectional data from 1849 children and adolescents participating in the National Health and Nutrition Examination Survey (NHANES) collected between 2011 and
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Shining a Light on Selenium: a Meta-analysis of Supplementation in Multiple Sclerosis Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-29 Mehrab Rahmani, Sina Pakkhesal, Saman Baharomid, Hanie Karimi, Reza Mosaddeghi-Heris, Mahnaz Talebi, Negar Aghaei, Alireza Rahimi-Mamaghani, Sarvin Sanaie, Amirreza Naseri
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Sex-Specific Associations of Five Serum Essential Metal Elements with Thyroid Nodules in Euthyroid Adults: a Cross‑sectional Study Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-29 Qintao Ma, Ying Li, Genfeng Yu, Siyang Liu, Yuqi Jiang, Hualin Duan, Dongmei Wang, Yajun He, Xingying Chen, Nanfang Yao, Xu Lin, Heng Wan, Jie Shen
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Signal Transduction Associated with Mn-induced Neurological Dysfunction Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-29 Xiao-wei Zheng, Yuan-yuan Fang, Jun-jie Lin, Jing-jing Luo, Shao-jun Li, Michael Aschner, Yue-ming Jiang
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Economic and Productive Comparison of Rutin and Rutin-Loaded Chitosan Alginate Nanoparticles Against Lead-Induced Oxidative Stress in Cobb and Arbor Broiler Breeds Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-28 Noha M. Wahed, Mohamed Abomosallam, Basma M Hendam, Zeinab Shouman, Nada MA Hashem, Shimaa A. Sakr
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Identification of the Hub Genes Linked to Lead (IV)-Induced Spleen Toxicity Using the Rat Model Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-28 Bing Yang, Zhongyuan Wang, Zhongze Hu, Shujuan Wang, Jingen Xu, Xiaofeng Li
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Association between the Composite Dietary Antioxidant Index and Stroke: A cross-sectional Study Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-28 Ting Wang, Haiyan Liu, Xiue Wei
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Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-27 Yunyun Ma, Lei Wang, Jing He, Xueping Ma, Jingjing Wang, Ru Yan, Wanrui Ma, Huiyan Ma, Yajuan Liu, Hongqian Sun, Xiaoxia Zhang, Shaobin Jia, Hao Wang
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Arsenic Exposure Induces Neuro-immune Toxicity in the Cerebral Cortex and the Hippocampus via Neuroglia and NLRP3 Inflammasome Activation in C57BL/6 Mice Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-27 Nan Yan, Zhengdong Wang, Zhou Li, Yang Zheng, Nan Chang, Kangjie Xu, Qian Wang, Xiaoxu Duan
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Spice-Induced Metal Contamination and Microbiological Risk Assessment of Instant Noodles Prepared for Human Consumption Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-27 Akaninyene Joseph, Uwem Edet, Edet Asanga, Favor Akpakpan Udoeyop, Bassey Ini Ubi, Glory Bebia, Ajoke F. I. Akindele, Regina Odu, Francisca Nwaokorie
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Selenium Nanoparticles Ameliorate Adverse Impacts of Aflatoxin in Nile Tilapia with Special Reference to Streptococcus agalactiae Infection Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-26 Ahmed H. Sherif, Mohsen A. Zommara
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Evaluating the Protective Effects of Melatonin Against Chronic Iron Administration in Male Wistar Rats: a Comparative Analysis of Affective, Cognitive, and Oxidative Stress with EDTA Chelator Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-26
Abstract Iron is the dominant metal in the brain and is distributed widely. However, it can lead to various neuropathological and neurobehavioral abnormalities as well as oxidative stress. On the other hand, melatonin, a pineal hormone, is known for its neuroprotective properties, as well as its ability to act as a natural chelator against oxidative stress. It has also been used as an antidepressant
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The Association between Magnesium Depletion Score and Hypertension in US Adults: Evidence from the National Health and Nutrition Examination Survey (2007–2018) Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-26
Abstract The magnesium depletion score (MDS) emerges as a new valuable predictor of the body’s magnesium status index. This study aims to explore the link between MDS and hypertension (HTN) using the National Health and Nutrition Examination Survey (NHANES) data. A total of 9708 participants from NHANES (2007–2018) were enrolled to investigate MDS’s connection with HTN. HTN was defined based on clinical
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Antibiotic Residues and Zinc Concentrations in the Livers and Kidneys of Portuguese Piglets—Relationship to Antibiotic and Zinc Resistance in Intestinal Escherichia coli Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-26 Olga Cardoso, Gabriela Assis, Maria M. Donato, Sara Carolina Henriques, Andreia Freitas, Fernando Ramos
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Ecological and Health Risk Assessment of Heavy Metals Bioaccumulation in Ganges Fish Near Varanasi, India Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-26 Bhargawi Mishra, Geeta J. Gautam, Rajnish Kumar Chaturvedi, Nasreen Ghazi Ansari, Vijaya Nath Mishra
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Serum Trace Element Levels in Cancer Patients Undergoing Chemotherapy: a Before-After Analysis Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-23 Hassan Rafieemehr, Abbas Farmany, Somayeh Ghorbani, Mohammad Jafari, Masumeh Maleki Behzad
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Heavy Metals Assessment and Health Risk to Consumers of Two Commercial Fish Species from Polyculture Fishponds in El-Sharkia and Kafr El-Sheikh, Egypt: Physiological and Biochemical Study Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-22 Mahmoud Mahrous M. Abbas, Salah M. EL-Sharkawy, Hassan R. Mohamed, Bassem E. Elaraby, Walaa M. Shaban, Metwally G. Metwally, Diaa M. G. Farrag
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Targeting Mitochondrial ATP-Synthase: Evolving Role of Chromium as a Regulator of Carbohydrate and Fat Metabolism Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-22
Abstract The micronutrient trivalent chromium, 3 + (Cr(III)), is postulated to play a role in carbohydrate, lipid, and protein metabolism. Although the mechanisms by which chromium mediates its actions are largely unknown, previous studies have suggested that pharmacological doses of chromium improve cardiometabolic symptoms by augmenting carbohydrate and lipid metabolism. Activation of AMP-activated
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Carvacrol Reduces Mercuric Chloride-Induced Testicular Toxicity by Regulating Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histopathological Changes Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-22 Hasan Şimşek, Cihan Gür, Sefa Küçükler, Mustafa İleritürk, Nurhan Akaras, Mehmet Öz, Fatih Mehmet Kandemir
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Assessment of Heavy Metals in Biscuit Samples Available in Iraqi Markets Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-22 Farqad Abbas Taher, Ali Abid Abojassim
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Association Between Copper Intake and Migraine: a National Cross-sectional Study Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-21 Yiyan Sun, Zhi Jin, Junqing Zhang, Hongyun Wu, Xiaotong Li, Leiyong Zhao, Wei Peng
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The Role of Chlorella vulgaris in Attenuating Infertility Induced by Cadmium Chloride via Suppressing Oxidative Stress and Modulating Spermatogenesis and Steroidogenesis in Male Rats Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-20 Mayada R Farag, Nesma I. El-naseery, Eman I. El behery, Doaa S. Nouh, Amany El-Mleeh, Ismail M.A. Mostafa, Mahmoud Alagawany, Alessandro Di Cerbo, Mahmoud M. Azzam, Suzan A. Mawed
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Dispersive Solid-phase Microextraction of Lead in Waters and Edible Lettuce and Dill Extracts in the Unified Bioaccessibility Method (UBM) Saliva Solution Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-20
Abstract A new thiosemicarbazide-modified, sulfonamide-based poly (styrene) adsorbent (T-CSPS) was prepared starting from the reaction of chlorosulfonated polystyrene and thiosemicarbazide. It was characterized by SEM–EDX, FT-IR, and zeta potential. The T-CSPS was used as an adsorbent for the first time for the dispersive solid-phase microextraction (d-SPµE) and preconcentration of Pb(II) ions from
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Assessing Trace Metal-Based Human Health Risks for Commonly Used Body Soaps in Bangladesh Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-20 Ashraful Hoque, Taznova Anwar Tanbi, Nakshi Saha, Sabbir Howlader, Nobonita Sarker, Aminul Islam Chowdhury, Amitava Bandyopadhyay, Shahidul Islam, Muhammad Abu Bakar, Nur E. Alam, Ashok Kumar Chakraborty, Sumon Ganguli
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Disrupting Development: Unraveling the Interplay of Aryl Hydrocarbon Receptor (AHR) and Wnt/β-Catenin Pathways in Kidney Development Under the Influence of Environmental Pollutants Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-20
Abstract Understanding the intricate molecular mechanisms governing aryl hydrocarbon receptor (AHR) and Wnt/β-Catenin pathways crosstalk is of paramount importance for elucidating normal development. We investigated the repercussions of aberrant activation of these signaling pathways on kidney development. HEK-293 cells were subjected to AHR and Wnt activators and inhibitors for 3 and 24 h. Subsequently
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Ginkgo Biloba Extract Can Antagonize Subchronic Arsenite Exposure-Induced Hepatocyte Senescence by Inhibiting Oxidative Damage and Inflammation in Rats Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-19 Xiong Chen, Fan Wu, Cheng Chen, Qian Ren, Aihua Zhang
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Dietary Magnesium Intake and Proteinuria: Is There a Relationship? Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-19 Abbas Mohtashamian, Negar Mozaffari-Rad, Alireza Soleimani, Hossein Akbari, Vahid Arabi, Nasrin Sharifi
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Cobalt Uptake by Food Plants and Accumulation in Municipal Solid Waste Materials Compost-amended Soil: Public Health Implications Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-19 Zafar Iqbal Khan, Asma Ashfaq, Kafeel Ahmad, Aima Iram Batool, Mehwish Aslam, Tasneem Ahmad, Naunain Mehmood, Ijaz Rasool Noorka, Abdel-Rhman Z. Gaafar, Mohamed S. Elshikh, Syed Sikandar Habib, Riaz Khan, Ilker Ugulu
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Biological Selenium Nanoparticles in Quail Nutrition: Biosynthesis and its Impact on Performance, Carcass, Blood Chemistry, and Cecal Microbiota Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-18 Fayiz M. Reda, Mahmoud Alagawany, Ayman S. Salah, Mohamed A. Mahmoud, Mahmoud M. Azzam, Alessandro Di Cerbo, Mohamed T. El-Saadony, Shaaban S. Elnesr
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Association Between Combined Polymetallic Exposure and Osteoporosis Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-18 Lidong Qin, Qiumei Liu, Tiantian Zhang, Xu Tang, Xiaoting Mo, Yujian Liang, Xuexiu Wang, Jiejing Cao, Chuwu Huang, Yufu Lu, Zhiyong Zhang, Jian Qin, Jiansheng Cai
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Serum Levels of Vitamins and Trace Elements in Patients with Visceral Leishmaniasis: a Systematic Review and Meta-analysis Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-18 Vaibhav Chaudhary, Sweta Kumari, Biplab Pal
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Understanding Cr(III) Action on Mitochondrial ATP Synthase and AMPK Efficacy: Insights from Previous Studies—a Review Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-18
Abstract Chromium supplementation has been notably recognized for its potential health benefits, especially in enhancing insulin sensitivity and managing glucose metabolism. However, recent studies have begun to shed light on additional mechanisms of action for chromium, expanding our understanding beyond its classical effects on the insulin-signaling pathway. The beta subunit of mitochondrial ATP
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Identification of Different Varieties of Oil Peony Seeds Combining ICP-MS with Chemometrics and Assessment of Associated Health Risk Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-16 Shuya Li, Dezhang Zhao, Yuan Shen, Lei Dai, Weihan Qin, Dan Yang, Yaxuan Li, Lin Yang, Yan Li, Dan He
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The Hepatorenal Protective Potential of Caffeic Acid Consumption on the Arsenic-Exposed Syrian Mice Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-16
Abstract Arsenic can induce lethal hepatorenal insufficiency by inducing progressive cytotoxicity in the two main body’s hemostatic regulators, the kidney and liver. In the current study, the hepatorenal protective impact of caffeic acid was investigated in arsenic-exposed Syrian mice. Twenty-four male Syrian mice (30 \(\pm\) 8 g) were provided and randomly divided into 4 groups of 6 receiving nothing
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Arsenic-Induced Ferroptosis in Chicken Hepatocytes via the Mitochondrial ROS Pathway Biol. Trace Elem. Res. (IF 3.9) Pub Date : 2023-12-16 Xinglin Gao, Qian Su, Hang Pan, Yanli You, Zhiyan Ruan, Yuhan Wu, Zhaoxin Tang, Lianmei Hu