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Nature-Inspired Scarless Healing: Guiding Biomaterials Design for Advanced Therapies. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-11-29 Fernando López Lasaosa,Yin Zhou,Jiliang Song,Yiyan He,Yuwen Cui,Rosa María Bolea Bailo,Zhongwei Gu
The use of biomaterials in the treatment of skin wounds has been steadily increasing over the last two decades. The key to the successful application of biomaterials in scar reduction is the up-to-date knowledge of the actors involved in accelerated healing and the cellular factors that can be implemented in bio-inspired materials. Natural models of scarless healing such as oral mucosa, foetal skin
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Magnetic Alignment of Collagen: Principles, Methods, Applications, and Fiber Alignment Analyses. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-11-29 Nashaita Y Patrawalla,Ravi Raj,Vida Nazar,Vipuil Kishore
Anisotropically aligned collagen scaffolds mimic the microarchitectural properties of native tissue, possess superior mechanical properties, and provide the essential physicochemical cues to guide cell response. Biofabrication methodologies to align collagen fibers include mechanical, electrical, magnetic, and microfluidic approaches. Magnetic alignment of collagen was first published in 1983 but widespread
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Strategies and challenges of mesenchymal stem cells-derived extracellular vesicles in infertility. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-11-27 Yuanxing Li,Siqi Wei,Shan Li,Peng-Sheng Zheng
Having genetically related offspring remains an unattainable dream for couples with reproductive failure. Mesenchymal stem cells (MSCs) are multipotent stromal cells derived from various human tissues and organs. As critical paracrine effectors of MSCs, extracellular vesicles (EVs) can carry and deliver bioactive content, thereby participating in intercellular communication and determining cell fate
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Utilization of Hydrogels in Mesenchymal Stem Cell-Based Therapy for Kidney Diseases. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-11-20 Jing Peng,Tinghang Yang,Shanshan Chen,Ningyue Deng,Xinyao Luo,Ruoxi Liao,Baihai Su
Kidney diseases are major global health problems, with high prevalence and mortality. However, current treatment strategies for kidney diseases fail to achieve satisfactory efficacy. Mesenchymal stem cell (MSC)-based therapy has been a promising strategy for treating kidney diseases. Preclinical studies have proven their safety and effectiveness in treating acute kidney injury (AKI) and chronic kidney
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Biomechanical Aspects in Bone Tumor Engineering. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-11-16 Ksenia Menshikh,Ivana Banicevic,Bojana Obradovic,Lia Rimondini
In the past decades, anticancer drug development brought the field of tumor engineering to a new level by the need of robust test systems. Simulating tumor microenvironment in vitro remains a challenge, and osteosarcoma-the most common primary bone cancer-is no exception. The growing evidence points to the inevitable connection between biomechanical stimuli and tumor chemosensitivity and aggressiveness
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Ex Vivo Peptide Decoration Strategies on Stem Cell Surfaces for Augmenting Endothelium Interaction. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-11-15 Hee Won Park,Chae Eun Lee,Sungjun Kim,Woo-Jin Jeong,Kyobum Kim
Ischemic vascular diseases remain leading causes of disability and death. Although various clinical therapies have been tried, reperfusion injury is a major issue, occurring when blood recirculates at the damaged lesion. As an alternative approach, cell-based therapy has emerged. Mesenchymal stem cells (MSCs) are attractive cellular candidates due to their therapeutic capacities, including differentiation
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Extracellular Vesicles: An Emerging Clinical Opportunity in Musculoskeletal Disease. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-11-06 Sanjeev Rampam,Jonathan M Carnino,Boyuan Xiao,Rehan R Khan,Steven Miyawaki,Graham S Goh
Extracellular vesicles are important mediators of cell-to-cell communication in the extracellular space. These membranous nanoparticles carry various molecules, often referred to as "cargo," which are delivered to nearby target cells. In the past decade, developments in nanotechnology have allowed for various new laboratory techniques for the increased utilization of extracellular vesicles in cellular
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Technological interventions enhancing curcumin bioavailability in wound healing therapeutics. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-10-28 Hemant Singh,Mukesh Dhanka,Indu Yadav,Sneh Gautam,Showkeen Muzamil Bashir,Narayan Chandra Mishra,Taruna Arora,Shabir Hassan
Wound healing has been a challenge in the medical field. Tremendous research has been carried to expedite wound healing by fabricating various formulations, some of which are now commercially available. However, owing to their natural source, people have been attracted to advanced formulations with herbal components. Among various herbs, curcumin has been a center of attraction from ancient times for
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3D Bioprinting in Vascular Tissue Engineering and Tissue Vascularization of Cardiovascular Diseases. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-10-26 Zhiyi Ye,Ben Omondi Ochieng,Leqian Zhao
In the 21st century, significant progress has been made in repairing damaged materials through material engineering. However, the creation of large-scale artificial materials still faces a major challenge in achieving proper vascularization. To address this issue, researchers have turned to biomaterials and three-dimensional (3D) bioprinting techniques, which allow for the combination of multiple biomaterials
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Interaction of Macrophages with Bone Healing Microenvironment: Mechanism and Biomaterials. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-10-26 Xiaoxuan Lu,Jike Gao,Weimin Bao,Jianguang Xu,Xiaoyu Sun,Yuanyin Wang,Bang Li
Extensive bone fractures, which can seriously impact both health and quality of life, cannot easily heal naturally, especially if the patient has an underlying medical condition or is aging. The most promising approach to addressing such fractures is bone regeneration through bone tissue engineering. Bone regeneration is a complex process that consists of three distinct phases: inflammation, repair
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Nanoparticle and Nanotopography-Induced Activation of the Wnt Pathway in Bone Regeneration. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-11-20 Chitra Jagannathan,Rachel Waddington,Wayne Nishio Ayre
Background and Aims: Recent research has focused on developing nanoparticle and nanotopography-based technologies for bone regeneration. The Wingless-related integration site (Wnt) signaling pathway has been shown to play a vital role in this process, in particular in osteogenic differentiation and proliferation. The exact mechanisms by which nanoparticles and nanotopographies activate the Wnt signaling
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From its Nature to its Function: Marine-Collagen-Based-Biomaterials for Hard Tissue Applications. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-09-30 Rogerio Pedro Pirraco,Gabriela S Diogo,Rui L Reis,Tiago H Silva
Rapidly growing demand for collagen-based therapeutic applications requires a great amount of collagen stock. Commercial collagen is mainly confined to mammalian sources, which have concerns about zoonotic disease transfer and, additionally, the problem of terrestrial animals' overexploitation, which, even so, does not meet the crescent demand for collagen. The extraction of collagen from marine organisms
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Global Bibliometric and Visualized Analysis of Tracheal Tissue Engineering Research. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-09-28 Jianwei Zhu,Yi Lu,Yibo Shan,Lei Yuan,Qiang Wu,Zhiming Shen,Fei Sun,Hongcan Shi
The development of tracheal tissue engineering (TTE) has seen a rapid growth in recent years. The purpose of this study was to investigate the global status, trends, and hotspots of TTE research based on bibliometrics and visualization analysis. Publications related to TTE were retrieved and included in the Web of Science Core Collection. VOSviewer and CiteSpace were used to generate knowledge maps
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Three-Dimensional Scaffolds for Intestinal Cell Culture: Fabrication, Utilization, and Prospects. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-09-22 Tiange Liu,Jia Gu,Caili Fu,Lingshan Su
The intestine is a visceral organ that integrates absorption, metabolism, and immunity, which is vulnerable to external stimulus. Researchers in the fields such as food science, immunology, and pharmacology have committed to developing appropriate in vitro intestinal cell models to study the intestinal absorption and metabolism mechanisms of various nutrients and drugs, or pathogenesis of intestinal
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Extracellular Vesicles from Urine-Derived Stem Cell for Tissue Engineering and Regenerative Medicine. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-09-22 Yi-Jun Dong,Juan-Juan Hu,Yu-Ting Song,Ya-Ya Gao,Mei-Jun Zheng,Chen-Yu Zou,Ming Xiong,Jesse Li-Ling,Hui Yang,Hui-Qi Xie
The potential of urine-derived stem cells (USCs) for tissue engineering and regenerative medicine has attracted much attention during the last few decades. However, it has been suggested that the effects of the USCs may be endowed by their paracrine extracellular vesicles (EVs) rather than their differentiation. Compared with the USCs, the USC-EVs can cross the barriers more easily and safely, and
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Trends in Adipose-Derived Stem Cell-Conditioned Medium: A Bibliometric and Visualized Review. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-09-04 Yu Cheng,Guangpeng Liu
Adipose-derived stem cell-conditioned medium (ADSC-CM) has been widely studied and used as a stem cell-based cell-free therapy. Due to the explosion of scientific publications in this field, it is difficult to review all relevant publications systematically, not mention quantitively. In this study, we combined bibliometrics with the conventional review method to summarize, analyze, and visualize the
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Recent advances in cell sheet-based tissue engineering for bone regeneration. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-08-28 Guoding Cao,Liling Ren,Dongyang Ma
In conventional bone tissue engineering, cells are seeded onto scaffolds to create three-dimensional tis-sues, but the cells on the scaffolds are unable to effectively perform their physiological functions due to their low density and viability. Cell sheet (CS) engineering is expected to be free from this limitation. CS engi-neering uses the principles of self-assembly and self-organization of endothelial
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Advances in in vitro blood-air barrier models and the use of nanoparticles in COVID-19 research. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-08-19 Neval Sevinç Ozdemir,Dmitry Belyaev,Manuel Nieto Castro,Sascha Balakin,Joerg Opitz,Hevi Wihadmadyatami,Rahmi Anggraeni,Deniz Yücel,Halime Kenar,Natalia Beshchasna,Ika Dewi Ana,Vasif N Hasirci
Respiratory infections caused by coronaviruses (CoVs) have become a major public health concern in the past two decades as revealed by the emergence of SARS-CoV in 2002, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The most severe clinical phenotypes commonly arise from exacerbation of immune response following the infection of alveolar epithelial cells localized at the pulmonary blood-air barrier. Preclinical
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Cellular senescence in craniofacial tissue regeneration:inducers, biomarkers, and interventions. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-08-11 Weibing Tang,Fangjun Huo,Jie Long,Siyuan Zhang,Weidong Tian
Craniofacial defects and dental tissue loss have significant negative impacts on the structure and function of jaws and face, often resulting in psychological issues in patients, emphasizing the urgent need for effective craniofacial tissue reconstruction. Unfortunately, natural regeneration of these tissues is limited. Dental-derived mesenchymal stem cells (MSCs) have emerged as a promising resource
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Call for Special Issue Papers: Artificial Intelligence in Tissue Engineering and Biology. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-07-19 Jason L Guo,Michael Januszyk,Michael T Longaker
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Hydroxyapatite/Polyurethane Scaffolds for Bone Tissue Engineering. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-08-21 Tianyu Zhang,Jingxuan Li,Yahui Wang,Weimo Han,Yan Wei,Yinchun Hu,Ziwei Liang,Xiaojie Lian,Di Huang
Polyurethane (PU) and PU ceramic scaffolds are the principal materials investigated for developing synthetic bone materials due to their excellent biocompatibility and biodegradability. PU has been combined with calcium phosphate (such as hydroxyapatite [HA] and tricalcium phosphate) to prepare scaffolds with enhanced mechanical properties and biocompatibility. This article reviews the latest progress
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The Host Response to Autogenous, Allogeneic, and Xenogeneic Treated Dentin Matrix/Demineralized Dentin Matrix-Oriented Tissue Regeneration. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-08-16 Tianyi Wang,Yongwen Guo
Dentin is a bone-like matrix that forms the bulk of the tooth. By fabricating dentin with protocols involving demineralization, sterilization, and preservation, treated dentin matrix (TDM)/demineralized dentin matrix (DDM) could be obtained, which is considered as a useful tool for bone and tooth-tissue regeneration. Non-negligible inflammatory and immune responses are reviewed in this article of autogenous
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Stem Cell-Based Therapies for Auditory Hair Cell Regeneration in the Treatment of Hearing Loss. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-08-10 Adeline Josephine Cumpata,Luminita Labusca,Luminita Mihaela Radulescu
The incidence and prevalence of hearing loss is increasing globally at an accelerated pace. Hair cells represent the sensory receptors of auditory and vestibular systems. Hair cell absence, loss or degeneration due to congenital diseases, trauma, toxicity, infection or advancing age, results in disabling hearing loss. Regenerative medicine approaches consisting in stem cell-based hair cell rescue or
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Exploring the Use of Animal Models in Craniofacial Regenerative Medicine: A Narrative Review. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-08-16 Seyed Ali Mosaddad,Ahmed Hussain,Hamid Tebyaniyan
The craniofacial region contains skin, bones, cartilage, the temporomandibular joint (TMJ), teeth, periodontal tissues, mucosa, salivary glands, muscles, nerves, and blood vessels. Applying tissue engineering therapeutically helps replace lost tissues after trauma or cancer. Despite recent advances, it remains essential to standardize and validate the most appropriate animal models to effectively translate
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New Insights and Advanced Strategies for In Vitro Construction of Vascularized Tissue Engineering. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-08-16 Jiancong Liang,Jing Zhao,Yunzi Chen,Bin Li,Ye Li,Feng Lu,Ziqing Dong
Inadequate vascularization is a significant barrier to clinical application of large-volume tissue engineered grafts. In contrast to in vivo vascularization, in vitro prevascularization shortens the time required for host vessels to grow into the graft core and minimizes necrosis in the core region of the graft. However, the challenge of prevascularization is to construct hierarchical perfusable vascular
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Current Status of Tissue Regenerative Engineering for the Treatment of Uterine Infertility. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-09-26 Di Huang,Junhui Liang,Jie Yang,Chunrun Yang,Xin Wang,Tianyu Dai,Thorsten Steinberg,Changzhong Li,Fei Wang
With the recent developments in tissue engineering, scientists have attempted to establish seed cells from different sources, create cell sheets through various technologies, implant them on scaffolds with various spatial structures, or load scaffolds with cytokines. These research results are very optimistic, bringing hope to the treatment of patients with uterine infertility. In this article, we
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Three-Dimensional Bioprinting of Biocompatible Photosensitive Polymers for Tissue Engineering Application. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-07-06 Joshua Lim,Sasinan Bupphathong,Wei Huang,Chih-Hsin Lin
Three-dimensional (3D) bioprinting, or additive manufacturing, is a rapid fabrication technique with the foremost objective of creating biomimetic tissue and organ replacements in hopes of restoring normal tissue function and structure. Generating the engineered organs with an infrastructure that is similar to that of the real organs can be beneficial to simulate the functional organs that work inside
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Advances of Blood Coagulation Factor XIII in Bone Healing. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-06-12 Yi Dang,Yi Zhang,Minghui Jian,Peng Luo,Nadia Anwar,Yaping Ma,Dingmei Zhang,Xin Wang
The biologic process of bone healing is complicated, involving a variety of cells, cytokines, and growth factors. As a result of bone damage, the activation of a clotting cascade leads to hematoma with a high osteogenic potential in the initial stages of healing. A major factor involved in this course of events is clotting factor XIII (FXIII), which can regulate bone defect repair in different ways
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Stem Cell-Derived Cardiomyocyte-Like Cells in Myocardial Regeneration. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-07-04 Pauline Cheng,Ahmad Rashad,Ankit Gangrade,Natan Roberto de Barros,Ali Khademhosseini,Jonathan Tam,Padmini Varadarajan,Devendra K Agrawal,Finosh G Thankam
Myocardial infarction results in the significant loss of cardiomyocytes (CMs) due to the ischemic injury following coronary occlusion leading to impaired contractility, fibrosis, and ultimately heart failure. Stem cell therapy emerged as a promising regenerative strategy to replenish the otherwise terminally differentiated CM to restore cardiac function. Multiple strategies have been applied to successfully
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Poor Result Reporting Rate in Cell Therapy Trials Registered at ClinicalTrials.gov. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-06-07 Takaharu Negoro,Hanayuki Okura,Shigekazu Hayashi,Tsutomu Arai,Akifumi Matsuyama
As research associates in clinical experiments, we have an obligation to disclose clinical methodologies and findings in full transparency in ethics. However, inadequate disclosure in results reporting clinical trials registered on ClinicalTrials.gov has been revealed, with approximately half the trial results not being reported in an applicable manner. Our recent study in clinical trials of regenerative
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Fatter Is Better: Boosting the Vascularization of Adipose Tissue Grafts. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-06-07 Ettore Limido,Andrea Weinzierl,Yves Harder,Michael D Menger,Matthias W Laschke
Adipose tissue resorption after fat grafting is a major drawback in plastic and reconstructive surgery, which is primarily caused by the insufficient blood perfusion of the grafts in the initial phase after transplantation. To overcome this problem, several promising strategies to boost the vascularization and, thus, increase survival rates of fat grafts have been developed in preclinical studies in
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Mesenchymal Stem Cells: Their Role in the Tumor Microenvironment. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-07-10 Jhon Alexander Ramírez Idarraga,Luz Marina Restrepo Múnera
Mesenchymal stem cells (MSCs) have been seen for years as great candidates for treating different diseases and an alternative to embryonic stem cells due to their differentiation capacity in vitro. More recent research has focused on their ability to modulate the immune response and regeneration at sites associated with inflammation, activities attributable to the release of trophic factors into the
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Modulation of Smooth Muscle Cell Phenotype for Translation of Tissue-Engineered Vascular Grafts. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-05-30 Sergio A Pineda-Castillo,Handan Acar,Michael S Detamore,Gerhard A Holzapfel,Chung-Hao Lee
Translation of small-diameter tissue-engineered vascular grafts (TEVGs) for the treatment of coronary artery disease (CAD) remains an unfulfilled promise. This is largely due to the limited integration of TEVGs into the native vascular wall-a process hampered by the insufficient smooth muscle cell (SMC) infiltration and extracellular matrix deposition, and low vasoactivity. These processes can be promoted
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Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-05-24 Laura Bracaglia,Themis Kyriakides
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Human Mesenchymal Stem Cells and Innovative Scaffolds for Bone Tissue Engineering Applications. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-06-30 Elisa Mazzoni,Maria Rosa Iaquinta,Maria Mosaico,Raffaella De Pace,Antonio D'Agostino,Mauro Tognon,Fernanda Martini
Stem cell-based therapy is a significant topic in regenerative medicine, with a predominant role being played by human mesenchymal stem cells (hMSCs). The hMSCs have been shown to be suitable in regenerative medicine for the treatment of bone tissue. In the last few years, the average lifespan of our population has gradually increased. The need of biocompatible materials, which exhibit high performances
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Preclinical Studies and Clinical Trials on Cell-Based Treatments for Meniscus Regeneration. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-06-14 Xiaoke Li,Dijun Li,Jiarong Li,Guishan Wang,Lei Yan,Haifeng Liu,Jingwei Jiu,Jiao Jiao Li,Bin Wang
Objective: This study aims at performing a thorough review of cell-based treatment strategies for meniscus regeneration in preclinical and clinical studies. Methods: The PubMed, Embase, and Web of Science databases were searched for relevant studies (both preclinical and clinical) published from the time of database construction to December 2022. Data related to cell-based therapies for in situ regeneration
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Attenuating Chronic Fibrosis: Decreasing Foreign Body Response with Acellular Dermal Matrix. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-06-07 Norah E Liang,Michelle F Griffin,Charlotte E Berry,Jennifer B Parker,Mauricio A Downer,Derrick C Wan,Michael T Longaker
Surgical implants are increasingly used across multiple medical disciplines, with applications ranging from tissue reconstruction to improving compromised organ and limb function. Despite their significant potential for improving health and quality of life, biomaterial implant function is severely limited by the body's immune response to its presence: this is known as the foreign body response (FBR)
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Organoid Culture Development for Skeletal Systems. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-06-23 Jia Qing,Qian Guo,Longwei Lv,Xiao Zhang,Yunsong Liu,Boon Chin Heng,Zheng Li,Ping Zhang,Yongsheng Zhou
Organoids are widely considered to be ideal in vitro models that have been widely applied in many fields, including regenerative medicine, disease research and drug screening. It is distinguished from other three-dimensional in vitro culture model systems by self-organization and sustainability in long-term culture. The three core components of organoid culture are cells, exogenous factors, and culture
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Biomaterials for Tissue-Engineered Treatment of Tendinopathy in Animal Models: A Systematic Review. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-04-18 Dijun Li,Guishan Wang,Jiarong Li,Lei Yan,Haifeng Liu,Jingwei Jiu,Xiaoke Li,Jiao Jiao Li,Bin Wang
To conduct a systematic review of studies reporting the treatment of tendon injury using biomaterials in animal models. A systematic search was conducted to retrieve studies involving animal models of tendon repair using biomaterials, in PubMed (database construction to August 2022) and Ovid-Embase (1946 to August 2022). Data related to tendon repair with biomaterials were extracted by two researchers
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The Effect of Growth Factors on Vaginal Wound Healing: A Systematic Review and Meta-analysis. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-06-06 Melissa J J van Velthoven,Aksel N Gudde,Frederique Struijs,Egbert Oosterwijk,Jan-Paul Roovers,Zeliha Guler,Carlijn R Hooijmans,Paul H J Kouwer
Surgical outcomes of pelvic organ prolapse (POP) surgery are poor, resulting in a 20% recurrence risk. Following the hypothesis that impaired wound healing is the main determinant of recurrent POP, growth factors have the potential to promote wound healing and may improve surgical outcomes. In this study, we systematically reviewed the effect of growth factors on vaginal wound healing in both in vitro
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Endodontic Tissue Regeneration: A Review for Tissue Engineers and Dentists. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-05-23 Esteban Astudillo-Ortiz,Pedro S Babo,Pia T Sunde,Kerstin M Galler,Manuel Gomez-Florit,Manuela E Gomes
The paradigm shift in the endodontic field from replacement toward regenerative therapies has witnessed the ever-growing research in tissue engineering and regenerative medicine targeting pulp-dentin complex in the past few years. Abundant literature on the subject that has been produced, however, is scattered over diverse areas of knowledge. Moreover, the terminology and concepts are not always consensual
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Periodontal Guided Tissue Regeneration Membranes: Limitations and Possible Solutions for the Bottleneck Analysis. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-05-02 Yi-Fei Ma,Xiang-Zhen Yan
Guided tissue regeneration (GTR) is an important surgical method for periodontal regeneration. By placing barrier membrane on the root surface of the tooth to guide the adhesion and proliferation of periodontal ligament cells, periodontal tissue regeneration can be achieved. This review intends to analyze the current limitations of GTR membranes and to propose possible solutions for developing new
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Cartilage Tissue Engineering in Practice: Preclinical Trials, Clinical Applications, and Prospects. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-05-02 Zhen Zhang,Yulei Mu,Huiqun Zhou,Hang Yao,Dong-An Wang
Articular cartilage defects significantly compromise the quality of life in the global population. Although many strategies are needed to repair articular cartilage, including microfracture, autologous osteochondral transplantation, and osteochondral allograft, the therapeutic effects remain suboptimal. In recent years, with the development of cartilage tissue engineering, scientists have continuously
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A Pilot Study on Result Reporting Rates from Clinical Trials of Regenerative Medicine. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-04-21 Takaharu Negoro,Hanayuki Okura,Shigekazu Hayashi,Tsutomu Arai,Akifumi Matsuyama
Sharing the methods and results of clinical trials with full transparency is an ethical obligation for those involved in clinical research. In this regard, ClinicalTrials.gov requires reporting of results to the registry within 1 year of completion of the trial. However, a poor result reporting rate has been pointed out, with approximately half the trial results not been reported. It has been suggested
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Bone Marrow Stem Cells with Tissue-Engineered Scaffolds for Large Bone Segmental Defects: A Systematic Review. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-04-20 Nicolò Rossi,Henrique Hadad,Maria Bejar-Chapa,Giuseppe M Peretti,Mark A Randolph,Robert W Redmond,Fernando P S Guastaldi
Critical-sized bone defects (CSBDs) represent a significant clinical challenge, stimulating researchers to seek new methods for successful bone reconstruction. The aim of this systematic review is to assess whether bone marrow stem cells (BMSCs) combined with tissue-engineered scaffolds have demonstrated improved bone regeneration in the treatment of CSBD in large preclinical animal models. A search
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Research Progress of Low-Intensity Pulsed Ultrasound in the Repair of Peripheral Nerve Injury. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-03-09 Xuling Liu,Derong Zou,Yinghan Hu,Yushi He,Jiayu Lu
Peripheral nerve injury (PNI) is a common disease that has profound impact on the health of patients, but has poor prognosis. The gold standard for the treatment of peripheral nerve defects is autologous nerve grafting; notwithstanding, due to the extremely high requirement for surgeons and medical facilities, there is great interest in developing better treatment strategies for PNI. Low-intensity
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Small-Caliber Tissue-Engineered Vascular Grafts Based on Human-Induced Pluripotent Stem Cells: Progress and Challenges. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-04-12 Junyi Ji,Hongju Xu,Chen Li,Jiesi Luo
Small-caliber tissue-engineered vascular grafts (TEVGs, luminal diameter <6 mm) are promising therapies for coronary or peripheral artery bypassing surgeries or emergency treatments of vascular trauma, and a robust seed cell source is required for scalable manufacturing of small-caliber TEVGs with robust mechanical strength and bioactive endothelium in future. Human-induced pluripotent stem cells (hiPSCs)
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Drug Delivery Approaches to Improve Tendon Healing. Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-03-08 Emmanuela Adjei-Sowah,Danielle S W Benoit,Alayna E Loiselle
Tendon injuries disrupt the transmission of forces from muscle to bone, leading to chronic pain, disability, and a large socioeconomic burden. Tendon injuries are prevalent; there are over 300,000 tendon repair procedures a year in the United States to address acute trauma or chronic tendinopathy. Successful restoration of function after tendon injury remains challenging clinically. Despite improvements
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A Case for Material Stiffness as a Design Parameter in Encapsulated Islet Transplantation Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-02-01 Courtney D. Johnson, Helim Aranda-Espinoza, John P. Fisher
Diabetes is a disease that plagues over 463 million people globally. Approximately 40 million of these patients have type 1 diabetes mellitus (T1DM), and the global incidence is increasing by up to 5% per year. T1DM is where the body's immune system attacks the pancreas, specifically the pancreatic beta cells, with antibodies to prevent insulin production. Although current treatments such as exogenous
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Advances in Hypoxia-Inducible Factor-1α Stabilizer Deferoxamine in Tissue Engineering Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-02-01 Yanlin Zhu, Bei Chang, Yuxuan Pang, Huimin Wang, Yanmin Zhou
Deferoxamine (DFO) is an iron chelator with FDA approval for the clinical treatment of iron excess. As a well-established stabilizer of hypoxia-inducible factor-1α (HIF-1α), DFO can efficiently upregulate HIF-1α and relevant downstream angiogenic factors, leading to accelerated vascularization. Moreover, as increasing studies have focused on DFO as a hypoxia-mimetic agent in recent years, it has been
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Glucose Metabolism: Optimizing Regenerative Functionalities of Mesenchymal Stromal Cells Postimplantation Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-01-25 Guotian Luo, Pauline Wosinski, Giuliana E. Salazar-Noratto, Morad Bensidhoum, Rena Bizios, Sayed-Amir Marashi, Esther Potier, Puyi Sheng, Hervé Petite
Mesenchymal stromal cells (MSCs) are considered promising candidates for regenerative medicine applications. Their clinical performance postimplantation, however, has been disappointing. This lack of therapeutic efficacy is most likely due to suboptimal formulations of MSC-containing material constructs. Tissue engineers, therefore, have developed strategies addressing/incorporating optimized cell
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Perspective in Achieving Stratified Articular Cartilage Repair Using Zonal Chondrocytes Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2023-01-24 Ching Ann Tee, Jongyoon Han, James Hoi Po Hui, Eng Hin Lee, Zheng Yang
Articular cartilage is composed of superficial, medial, and deep zones, which endow the tissue with biphasic mechanical properties to withstand shearing force and compressional loading. The tissue has very limited self-healing capacity once it is damaged due to its avascular nature. To prevent the early onset of osteoarthritis, surgical intervention is often needed to repair the injured cartilage.
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A Review on Three-Dimensional Printed Silicate-Based Bioactive Glass/Biodegradable Medical Synthetic Polymer Composite Scaffolds Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2022-12-21 Fulong Li, Xiaohong Chen, Ping Liu
In recent years, tissue engineering scaffolds have turned into the preferred option for the clinical treatment of pathological and traumatic bone defects. In this field, silicate-based bioactive glasses (SBGs) and biodegradable medical synthetic polymers (BMSPs) have attracted a great deal of attention owing to their shared exceptional advantages, like excellent biocompatibility, good biodegradability
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Systematic Evaluation of Spinal Cord Injury Animal Models in the Field of Biomaterials Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2022-12-09 Kest Verstappen, René Aquarius, Alexey Klymov, Kimberley E. Wever, Lyan Damveld, Sander C. G. Leeuwenburgh, Ronald H. M. A. Bartels, Carlijn R. Hooijmans, X. Frank Walboomers
The large number of animal models used in spinal cord injury (SCI) research complicates the objective selection of the most appropriate model to investigate the efficacy of biomaterial-based therapies. This systematic review aims to identify a list of relevant animal models of SCI by evaluating the confirmation of SCI and animal survival in all published SCI models used in biomaterials research up
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Optimization of Application-Driven Development of In Vitro Neuromuscular Junction Models Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2022-12-09 Julie B. Strickland, Katie Davis-Anderson, Sofiya Micheva-Viteva, Scott Twary, Rashi Iyer, Jennifer Foster Harris, Emilia A. Solomon
Neuromuscular junctions (NMJs) are specialized synapses responsible for signal transduction between motor neurons (MNs) and skeletal muscle tissue. Malfunction at this site can result from developmental disorders, toxic environmental exposures, and neurodegenerative diseases leading to severe neurological dysfunction. Exploring these conditions in human or animal subjects is restricted by ethical concerns
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Fibrinolysis Regulation: A Promising Approach to Promote Osteogenesis Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2022-12-09 Haiping Lu, Lan Xiao, Weiqun Wang, Xuyan Li, Yaping Ma, Yi Zhang, Xin Wang
Soon after bone fracture, the initiation of the coagulation cascade results in the formation of a blood clot, which acts as a natural material to facilitate cell migration and osteogenic differentiation at the fracture site. The existence of hematoma is important in early stage of bone healing, but the persistence of hematoma is considered harmful for bone regeneration. Fibrinolysis is recently regarded
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Extracellular Microenvironmental Control for Organoid Assembly Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2022-12-09 Kathryn M. Sullivan, Eunkyung Ko, Eun Mi Kim, William C. Ballance, John D. Ito, Madeleine Chalifoux, Young Jun Kim, Rashid Bashir, Hyunjoon Kong
Organoids, which are multicellular clusters with similar physiological functions to living organs, have gained increasing attention in bioengineering. As organoids become more advanced, methods to form complex structures continue to develop. There is evidence that the extracellular microenvironment can regulate organoid quality. The extracellular microenvironment consists of soluble bioactive molecules
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Recent Advances in Senotherapeutics Delivery Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2022-12-09 Ji Young Choi, Samantha F. Yee, Tzvetelina Tchangalova, Guang Yang, John P. Fisher
Accumulation of senescent cells (SnCs) in various tissue types has been connected to an occurrence of different age-related diseases that are indicated by its own tissue-specific hallmarks. Discovery of novel senolytic compounds that target major cellular mechanisms to inhibit the level of SnCs within the specific tissues or organs has been an emerging field in the age-related disease research. Although
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Synthetic Fibroblasts: Terra Incognita in Cardiac Regeneration Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2022-12-09 Albert Chang, Jonathan Tam, Devendra K. Agrawal, Huinan Hannah Liu, Padmini Varadarajan, Ramdas Pai, Finosh G. Thankam
Ischemic heart disease, a major risk factor for myocardial infarction (MI), occurs when the blood vessels supplying oxygen-rich blood to the heart become partially or fully occluded by lipid-rich plaques, resulting in myocardial cell death, remodeling, and scarring. In addition, MI occurs as result of lipid-rich plaque rupture, resulting in thrombosis and vessel occlusion. Cardiac fibroblasts (CFs)
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Three-Dimensional Culture for In Vitro Folliculogenesis in the Aspect of Methods and Materials Tissue Eng. Part B Rev. (IF 6.4) Pub Date : 2022-12-09 Sureerat Khunmanee, Hansoo Park
In vitro ovarian follicle culture is a reproduction technique used to obtain fertilizable oocytes, for overcoming fertility issues due to premature ovarian failure. This requires the establishment of an in vitro culture model that is capable of better simulating the in vivo ovarian growth environment. Two-dimensional (2D) culture systems have been successfully set up in rodent models. However, they