Facile preparation of hyperbranched polymers (HPs) have been advanced tremendously by the use of either various multifunctional agents-mediated controlled living radical polymerizations or a highly reactive ABx units-modulated polycondensation reactions, however, it remain so far, to our knowledge, a significant challenge to prepare HPs with simultaneously precisely controlled degree of branching (DB)

Native platelets perform a number of functions within the wound healing process, including interacting with fibrin fibers at the wound site to bring about retraction after clot formation. Clot retraction improves clot stability and enhances the function of the fibrin network as a provisional matrix to support cellular infiltration of the wound site, thus facilitating tissue repair and remodeling after

Single-cell microarrays are emerging tools to unravel intrinsic diversity within complex cell populations, opening up new approaches for the in-depth understanding of highly-relevant diseases. However, most of the current methods for their fabrication are based on cumbersome patterning approaches, employing organic solvents and/or expensive materials. Here, we demonstrate an unprecedented green-chemistry

Regeneration of large sized acute and chronic wounds provoked by severe burns and diabetes is a major concern worldwide. Availability of immunologically compatible matrix with wide range of regenerative medical applications, more specifically, for non-healing chronic wounds is an unmet clinical need. Extrapolating the in vitro tissue engineering experiences for in vivo guided wound regeneration could

Glioblastoma (GBM) is the most devastating brain cancer, and cures remain elusive with currently available neurosurgical, pharmacological and radiation approaches. While retrovirus- and adenovirus-mediated suicide gene therapy using DNA encoding herpes simplex virus-thymidine kinase (HSV-tk) and prodrug ganciclovir has been suggested as a promising strategy, a non-viral approach for treatment in an

Cell-penetrating peptides (CPPs) have been widely utilized as efficient molecular tools for the delivery of bioactive cargoes such as peptides, proteins, and genetic material. However, to improve their versatility as tools in biological environments, the resistance of CPPs to enzymatic degradation and their structural stability must be improved to achieve long-term efficacy. Here, we designed and synthesized

Towards osteochondral tissue construction, the present study introduced a bilayer scaffold to induce sequential chondrogenesis and osteogenesis of stem cells in vitro. Two scaffolds that both based on poly (L-glutamic acid) (PLGA) and chitosan (CS) were combined to form the bilayer scaffold. The cartilage region was the covalently cross-linked PLGA/CS hydrogel with tubular pore structure, possessing

Biodegradable cardiac patch is desirable to possess mechanical properties mimicking native myocardium for heart infarction treatment. We fabricated a series of anisotropic and biodegradable polyurethane porous scaffolds via thermally induced phase separation (TIPS) and tailored their mechanical properties by using various polyurethanes with different soft segments and varying polymer concentrations

High invasion and metastasis are the major obstacles for the successful therapy of breast cancer. Indocyanine green (ICG), a photosensitizer for photothermal therapy (PTT), shows potent anticancer efficacy when combined with the chemotherapeutic drug doxorubicin (DOX). Human serum albumin (HSA), a biocompatible carrier material, has been successfully used for the delivery of paclitaxel (Abraxane).

Materials exhibiting "bio-inert properties" are essential for developing medical devices, because they are less recognized as foreign substances by proteins and cells in the living body. We have reported that the presence of intermediate water (IW), the water molecules loosely bound to a polymer, is a useful index of the bio-inertness of materials. Here, we analyzed the hydration state and the responses

Purpose: Gene therapy is an important therapeutic strategy for cancer. Nanoparticles are used for non-invasive gene delivery, which have great potential in tumor therapy. However, it is a challenge to construct a targeted gene delivery vector with high gene delivery efficiency, good biocompatibility and multiple functions. Method: Herein, we designed magnetic mesoporous silica nanoparticles loading

Contact lens is a major risk factor for microbial keratitis among contact lens wearers. Chemical strategies that can prevent microbial adhesion and biofilm formation are required to improve wearer’s hygiene and safety. Taking advantage of the materials-independent properties of polydopamine (pDA) coating, we investigated the role of covalent/non-covalent interactions of the antimicrobials and pDA in

Calcium phosphate cements (CPCs) have been widely used for the study of bone regeneration because of their excellent physical and chemical properties, but poor biocompatibility and lack of osteoinductivity limit potential clinical applications. In order to overcome these limitations, and based on our previous research, CPC scaffolds were prepared with CPC as the principal material and polyethylene