-
Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-17 Huan Shen, Li Pan, Keke Ning, Yuefei Fang, Bahtiyor Muhitdinov, Ergang Liu, Yongzhuo Huang
Acute lung injury (ALI) is a fatal respiratory disease caused by overreactive immune reactions (e.g., SARS-CoV-2 infection), with a high mortality rate. Its treatment is often compromised by inefficient drug delivery barriers and insufficient potency of the currently used drugs. Therefore, developing a highly effective lung-targeted drug delivery strategy is a pressing clinical need. In this study
-
scRNA-seq analysis discovered suppression of immunomodulatory dependent inflammatory response in PMBCs exposed to silver nanoparticles J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-17 Haribalan Perumalsamy, Xiao Xiao, Hyun-Yi Kim, Tae-Hyun Yoon
The assessment of AgNPs toxicity in vitro and in vivo models are frequently conflicting and inaccurate. Nevertheless, single cell immunological responses in a heterogenous environment have received little attention. Therefore, in this study, we have performed in-depth analysis which clearly revealed cellular-metal ion association as well as specific immunological response. Our study didn’t show significant
-
H2O2 self-supplying and GSH-depleting nanosystem for amplified NIR mediated-chemodynamic therapy of MRSA biofilm-associated infections J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-16 Yulan Zhao, Yang Wu, Quan Xu, Yi Liu, Zhiyong Song, Heyou Han
Reactive oxygen species (ROS) has emerged as potent therapeutic agents for biofilm-associated bacterial infections. Chemodynamic therapy (CDT), involving the generation of high-energy ROS, displays great potential in the therapy of bacterial infections. However, challenges such as insufficient hydrogen peroxide (H2O2) and over-expressed glutathione (GSH) levels within the microenvironment of bacterial
-
Anti-inflammatory and anti-oxidative electrospun nanofiber membrane promotes diabetic wound healing via macrophage modulation J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-16 Jibing He, Shasha Zhou, Jiaxing Wang, Binbin Sun, Dalong Ni, Jinglei Wu, Xiaochun Peng
In the inflammatory milieu of diabetic chronic wounds, macrophages undergo substantial metabolic reprogramming and play a pivotal role in orchestrating immune responses. Itaconic acid, primarily synthesized by inflammatory macrophages as a byproduct in the tricarboxylic acid cycle, has recently gained increasing attention as an immunomodulator. This study aims to assess the immunomodulatory capacity
-
Nanoscale engineering of gold nanostars for enhanced photoacoustic imaging J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-16 Rui Zhang, Sven Thoröe-Boveleth, Dmitry N. Chigrin, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Photoacoustic (PA) imaging is a diagnostic modality that combines the high contrast resolution of optical imaging with the high tissue penetration of ultrasound. While certain endogenous chromophores can be visualized via PA imaging, many diagnostic assessments require the administration of external probes. Anisotropic gold nanoparticles are particularly valued as contrast agents, since they produce
-
Development of rice bran-derived nanoparticles with excellent anti-cancer activity and their application for peritoneal dissemination J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-16 Daisuke Sasaki, Hinako Suzuki, Kosuke Kusamori, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa
Rice bran a by-product of the rice milling process is currently underutilized. Recent studies have shown that plant-derived nanoparticles (pdNPs) can be mass-produced at a low cost and exhibit biological and therapeutic activities. Rice bran contains various anti-cancer compounds, including γ-oryzanol and γ-tocotrienol, and rice bran-derived nanoparticles (rbNPs) can be employed as novel therapeutic
-
Tetrahedral framework nucleic acids for improving wound healing J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-16 Wanqing Zou, Jing Lu, Luyong Zhang, Duanping Sun
Wounds are one of the most common health issues, and the cost of wound care and healing has continued to increase over the past decade. In recent years, there has been growing interest in developing innovative strategies to enhance the efficacy of wound healing. Tetrahedral framework nucleic acids (tFNAs) have emerged as a promising tool for wound healing applications due to their unique structural
-
Hypoxia preconditioning of adipose stem cell-derived exosomes loaded in gelatin methacryloyl (GelMA) promote type H angiogenesis and osteoporotic fracture repair J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-15 Xiaoqun Li, Shuo Fang, Shaohai Wang, Yang Xie, Yan Xia, Panfeng Wang, Zichen Hao, Shuogui Xu, Yuntong Zhang
The challenges posed by delayed atrophic healing and nonunion stand as formidable obstacles in osteoporotic fracture treatment. The processes of type H angiogenesis and osteogenesis emerge as pivotal mechanisms during bone regeneration. Notably, the preconditioning of adipose-derived stem cell (ADSC) exosomes under hypoxic conditions has garnered attention for its potential to augment the secretion
-
Injectable Bombyx mori (B. mori) silk fibroin/MXene conductive hydrogel for electrically stimulating neural stem cells into neurons for treating brain damage J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-14 Zhangze Yang, Yuxin You, Xiangyu Liu, Quan Wan, Zongpu Xu, Yajun Shuai, Jie Wang, Tingbiao Guo, Jiaqi Hu, Junhui Lv, Meng Zhang, Mingying Yang, Chuanbin Mao, Shuxu Yang
Brain damage is a common tissue damage caused by trauma or diseases, which can be life-threatening. Stem cell implantation is an emerging strategy treating brain damage. The stem cell is commonly embedded in a matrix material for implantation, which protects stem cell and induces cell differentiation. Cell differentiation induction by this material is decisive in the effectiveness of this treatment
-
Nitric oxide nano-reactor DNMF/PLGA enables tumor vascular microenvironment and chemo-hyperthermia synergetic therapy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-13 Ruoyao Wang, Long Cheng, Lingyun He, Chier Du, Haiyang Wang, Bohao Peng, Xiaoqing Yu, Weiwei Liu, Wenpei Luo, Haitao Ran, Lu Yang
Breast cancer ranks first among malignant tumors, of which triple-negative breast cancer (TNBC) is characterized by its highly invasive behavior and the worst prognosis. Timely diagnosis and precise treatment of TNBC are substantially challenging. Abnormal tumor vessels play a crucial role in TNBC progression and treatment. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis
-
Cancer cell-specific and pro-apoptotic SMAC peptide-doxorubicin conjugated prodrug encapsulated aposomes for synergistic cancer immunotherapy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-13 Jinseong Kim, Man Kyu Shim, Yujeong Moon, Jeongrae Kim, Hanhee Cho, Wan Su Yun, Nayeon Shim, Joon-Kyung Seong, Yonghyun Lee, Dong-Kwon Lim, Kwangmeyung Kim
Immunogenic cell death (ICD) is a crucial approach to turn immunosuppressive tumor microenvironment (ITM) into immune-responsive milieu and improve the response rate of immune checkpoint blockade (ICB) therapy. However, cancer cells show resistance to ICD-inducing chemotherapeutic drugs, and non-specific toxicity of those drugs against immune cells reduce the immunotherapy efficiency. Herein, we propose
-
Non-stem cell-derived exosomes: a novel therapeutics for neurotrauma J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-12 Xinyu Nie, Tianyang Yuan, Tong Yu, Zhihe Yun, Tao Yu, Qinyi Liu
Neurotrauma, encompassing traumatic brain injuries (TBI) and spinal cord injuries (SCI) impacts a significant portion of the global population. While spontaneous recovery post-TBI or SCI is possible, recent advancements in cell-based therapies aim to bolster these natural reparative mechanisms. Emerging research indicates that the beneficial outcomes of such therapies might be largely mediated by exosomes
-
Application of fluorocarbon nanoparticles of 131I-fulvestrant as a targeted radiation drug for endocrine therapy on human breast cancer J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-12 Li Zhi, Chen Cheng, Luo Jing, Peng Zhi-Ping, Yang Lu, Tian Yan, Wang Zhi-Gang, Yin Guo-Bing
Breast cancer is the most prevalent malignant tumor among women, with hormone receptor-positive cases constituting 70%. Fulvestrant, an antagonist for these receptors, is utilized for advanced metastatic hormone receptor-positive breast cancer. Yet, its inhibitory effect on tumor cells is not strong, and it lacks direct cytotoxicity. Consequently, there's a significant challenge in preventing recurrence
-
Nanoscale myelinogenesis image in developing brain via super-resolution nanoscopy by near-infrared emissive curcumin-BODIPY derivatives J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-11 Junyang Chen, Yifan Yu, Siyou Wang, Yu Shen, Yupeng Tian, Loris Rizzello, Kui Luo, Xiaohe Tian, Tinghua Wang, Liulin Xiong
Understanding the intricate nanoscale architecture of neuronal myelin during central nervous system development is of utmost importance. However, current visualization methods heavily rely on electron microscopy or indirect fluorescent method, lacking direct and real-time imaging capabilities. Here, we introduce a breakthrough near-infrared emissive curcumin-BODIPY derivative (MyL-1) that enables direct
-
A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-11 Liangzhi Gong, Zhengsheng Chen, Kai Feng, Lei Luo, Juntao Zhang, Ji Yuan, Yajing Ren, Yang Wang, Xianyou Zheng, Qing Li
Chemotherapy is an important therapeutic approach for malignant tumors for it triggers apoptosis of cancer cells. However, chemotherapy also induces senescence of stromal cells in the tumor microenvironment to promote tumor progression. Strategies aimed at killing tumor cells while simultaneously eliminating senescent stromal cells represent an effective approach to cancer treatment. Here, we developed
-
Genetically engineered membrane-based nanoengagers for immunotherapy of pancreatic cancer J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-11 Haoqi Zhang, Yuanke Li, Helong Kang, Jingping Lan, Lin Hou, Zhengbang Chen, Fan Li, Yanqin Liu, Jiliang Zhao, Na Li, Yajuan Wan, Yiping Zhu, Zhen Zhao, Hongkai Zhang, Jie Zhuang, Xinglu Huang
Modulating macrophages presents a promising avenue in tumor immunotherapy. However, tumor cells have evolved mechanisms to evade macrophage activation and phagocytosis. Herein, we introduced a bispecific antibody-based nanoengager to facilitate the recognition and phagocytosis of tumor cells by macrophages. Specifically, we genetically engineered two single chain variable fragments (scFv) onto cell
-
Microneedles loaded with cerium-manganese oxide nanoparticles for targeting macrophages in the treatment of rheumatoid arthritis J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-11 Tian Xia, Yuting Zhu, Kaiqiang Li, Ke Hao, Yingqian Chai, Hongyi Jiang, Chao Lou, Jiachen Yu, Wei Yang, Jilong Wang, Junjie Deng, Zhen Wang
Rheumatoid arthritis (RA) is a prevalent inflammatory autoimmune disease characterised by persistent inflammation and joint damage with elevated levels of reactive oxygen species (ROS). Current treatment modalities for RA have significant limitations, including poor bioavailability, severe side effects, and inadequate targeting of inflamed joints. Herein, we synthesised cerium/manganese oxide nanoparticles
-
3D-printed bredigite scaffolds with ordered arrangement structures promote bone regeneration by inducing macrophage polarization in onlay grafts J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-11 Yaowei Xuan, Yibo Guo, Lin Li, Yuzhang, Chenping Zhang, RuiJin, Xuelai Yin, Zhen Zhang
Bone tissue engineering scaffolds may provide a potential strategy for onlay bone grafts for oral implants. For determining the fate of scaffold biomaterials and osteogenesis effects, the host immune response is crucial. In the present study, bredigite (BRT) bioceramic scaffolds with an ordered arrangement structure (BRT-O) and a random morphology (BRT-R) were fabricated. The physicochemical properties
-
A proof-of-concept study on bioorthogonal-based pretargeting and signal amplify radiotheranostic strategy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-10 Hongzhang Yang, Xinying Zeng, Jia Liu, Jingchao Li, Yun Li, Qinglin Zhang, Linlin Shu, Huanhuan Liu, Xueqi Wang, Yuanyuan Liang, Ji Hu, Lumei Huang, Zhide Guo, Xianzhong Zhang
Radiotheranostics differs from the vast majority of other cancer therapies in its capacity for simultaneous imaging and therapy, and it is becoming more widely implemented. A balance between diagnostic and treatment requirements is essential for achieving effective radiotheranostics. Herein, we propose a proof-of-concept strategy aiming to address the profound differences in the specific requirements
-
Ce6-modified Fe ions-doped carbon dots as multifunctional nanoplatform for ferroptosis and photodynamic synergistic therapy of melanoma J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-10 Haiqiu Li, Yichen Dou, Hang Yang, Hanlin Xing, Cheng Zhu, Tao Wang, Zhaopeng Xuan, Mingxi Yang
Despite the higher sensitivity of melanoma towards ferroptosis and photodynamic therapy (PDT), the lack of efficient ferroptosis inducers and the poor solubility of photosensitizers restrict their synergistic strategies. With unique advantages, carbon dots (CDs) are expected to serve as innovative building blocks for combination therapy of cancers. Herein, an ferroptosis/PDT integrated nanoplatform
-
UiO-66 nanoparticles combat influenza A virus in mice by activating the RIG-I-like receptor signaling pathway J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-09 Ruijing Su, Xinsen Li, Jin Xiao, Jiawei Xu, Jijing Tian, Tianlong Liu, Yanxin Hu
The Influenza A virus (IAV) is a zoonotic pathogen that infects humans and various animal species. Infection with IAV can cause fever, anorexia, and dyspnea and is often accompanied by pneumonia characterized by an excessive release of cytokines (i.e., cytokine storm). Nanodrug delivery systems and nanoparticles are a novel approach to address IAV infections. Herein, UiO-66 nanoparticles (NPs) are
-
Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-09 Wenting Chen, Fangfang Hu, Qian Gao, Caiyun Zheng, Que Bai, Jinxi Liu, Na Sun, Wenhui Zhang, Yanni Zhang, Kai Dong, Tingli Lu
Chemodynamic therapy (CDT) based on intracellular Fenton reaction to produce highly cytotoxic reactive oxygen species (ROS) has played an essential role in tumor therapy. However, this therapy still needs to be improved by weakly acidic pH and over-expression of glutathione (GSH) in tumor microenvironment (TEM), which hinders its future application. Herein, we reported a multifunctional bimetallic
-
The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-07 Wen Deng, Haojie Shang, Yonghua Tong, Xiao Liu, Qiu Huang, Yu He, Jian Wu, Xiaozhuo Ba, Zhiqiang Chen, Yuan Chen, Kun Tang
Immune checkpoint blockers (ICBs) have been applied for cancer therapy and achieved great success in the field of cancer immunotherapy. Nevertheless, the broad application of ICBs is limited by the low response rate. To address this issue, increasing studies have found that the induction of immunogenic cell death (ICD) in tumor cells is becoming an emerging therapeutic strategy in cancer treatment
-
Nanoplastics causes heart aging/myocardial cell senescence through the Ca2+/mtDNA/cGAS-STING signaling cascade J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-06 Kaihao Wang, Yipeng Du, Peixin Li, Chang Guan, Min Zhou, Lanlan Wu, Zengfu Liu, Zheng Huang
Nanoplastics (NPs) are now a new class of pollutants widely present in the soil, atmosphere, freshwater and marine environments. Nanoplastics can rapidly penetrate cell membranes and accumulate in human tissues and organs, thus posing a potential threat to human health. The heart is the main power source of the body. But up to now, the toxicological effects of long-term exposure to nanoplastics on
-
Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-06 Qianying Du, Ying Luo, Lian Xu, Chier Du, Wenli Zhang, Jie Xu, Yun Liu, Bo Liu, Sijin Chen, Yi Wang, Zhigang Wang, Haitao Ran, Junrui Wang, Dajing Guo
The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combating tumor proliferation, recurrence and metastasis, current apoptosis-based metalloimmunotherapy fails to elicit sufficient immune response for HCC. A smart responsive bimetallic nanovaccine was constructed to induce immunogenic
-
Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-06 Shi-Yuan Yang, Yue Hu, Ran Zhao, Yu-Ning Zhou, Yu Zhuang, Yan Zhu, Xiao-Li Ge, Ting-Wei Lu, Kai-Li Lin, Yuan-Jin Xu
Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in the pathogenesis of the alveolar bone defect caused by periodontitis. Unfortunately, there is still a lack of ideal therapeutic strategies for periodontitis that can regenerate the alveolar bone while remodeling the osteoimmune microenvironment. Quercetin, as a monomeric flavonoid, has
-
Glioma-targeted oxaliplatin/ferritin clathrate reversing the immunosuppressive microenvironment through hijacking Fe2+ and boosting Fenton reaction J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-05 Xue Li, Ying Cheng, Zhifu Yang, Qifeng Ji, Menglei Huan, Weiliang Ye, Miao Liu, Bangle Zhang, Daozhou Liu, Siyuan Zhou
Glioma is easy to develop resistance to temozolomide (TMZ). TMZ-resistant glioma secretes interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), recruiting regulatory T cell (Treg) and inhibiting the activity of T cells and natural killer cell (NK cell), subsequently forming an immunosuppressive microenvironment. Oxaliplatin (OXA) greatly inhibits the proliferation of TMZ-resistant glioma
-
Spike structure of gold nanobranches induces hepatotoxicity in mouse hepatocyte organoid models J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-05 Rui Zhang, Dan Li, Ruibo Zhao, Dandan Luo, Yeting Hu, Shengyan Wang, Xiaolu Zhuo, M. Zubair Iqbal, Han Zhang, Qianqian Han, Xiangdong Kong
Gold nanoparticles (GNPs) have been extensively recognized as an active candidate for a large variety of biomedical applications. However, the clinical conversion of specific types of GNPs has been hindered due to their potential liver toxicity. The origin of their hepatotoxicity and the underlying key factors are still ambiguous. Because the size, shape, and surfactant of GNPs all affect their properties
-
Nano-enabled agrochemicals: mitigating heavy metal toxicity and enhancing crop adaptability for sustainable crop production J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-05 Abazar Ghorbani, Abolghassem Emamverdian, Necla Pehlivan, Meisam Zargar, Seyed Mehdi Razavi, Moxian Chen
The primary factors that restrict agricultural productivity and jeopardize human and food safety are heavy metals (HMs), including arsenic, cadmium, lead, and aluminum, which adversely impact crop yields and quality. Plants, in their adaptability, proactively engage in a multitude of intricate processes to counteract the impacts of HM toxicity. These processes orchestrate profound transformations at
-
Microfluidics-enabled fluorinated assembly of EGCG-ligands-siTOX nanoparticles for synergetic tumor cells and exhausted t cells regulation in cancer immunotherapy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-04 Xiaowei Han, Guozheng Zhang, Xiaozhen Wu, Shufeng Xu, Jiahuan Liu, Kaikai Wang, Tianqing Liu, Pengkai Wu
Immune checkpoint inhibitor (ICI)-derived evolution offers a versatile means of developing novel immunotherapies that targets programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) axis. However, one major challenge is T cell exhaustion, which contributes to low response rates in "cold" tumors. Herein, we introduce a fluorinated assembly system of LFNPs/siTOX complexes consisting of fluorinated
-
EphA2-specific microvesicles derived from tumor cells facilitate the targeted delivery of chemotherapeutic drugs for osteosarcoma therapy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-03 Zhenggang Wang, Zhiyi He, Junlai Wan, Anmin Chen, Peng Cheng, Wentao Zhu
Despite advances in surgery and chemotherapy, the survival of patients with osteosarcoma (OS) has not been fundamentally improved over the last two decades. Microvesicles (MVs) have a high cargo-loading capacity and are emerging as a promising drug delivery nanoplatform. The aim of this study was to develop MVs as specifically designed vehicles to enable OS-specific targeting and efficient treatment
-
Facile synthesis of Gd/Ru-doped fluorescent carbon dots for fluorescent/MR bimodal imaging and tumor therapy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-02 Yupeng Shi, Yaning Xia, Mengyang Zhou, Yifei Wang, Jianfeng Bao, Yong Zhang, Jingliang Cheng
Functional metal doping endows fluorescent carbon dots with richer physical and chemical properties, greatly expanding their potential in the biomedical field. Nonetheless, fabricating carbon dots with integrated functionality for diagnostic and therapeutic modalities remains challenging. Herein, we develop a simple strategy to prepare Gd/Ru bimetallic doped fluorescent carbon dots (Gd/Ru-CDs) via
-
Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-01 Peng Xue, Zhiyong Chang, Hao Chen, Hongzhong Xi, Xiaoxue Tan, Shuai He, Haishi Qiao, Xiaohong Jiang, Xin Liu, Bin Du
Bone defects remain a significant challenge in clinical orthopedics, but no targeted medication can solve these problems. Inspired by inflammatory targeting properties of macrophages, inflammatory microenvironment of bone defects was exploited to develop a multifunctional nanocarrier capable of targeting bone defects and promoting bone regeneration. The avidin-modified black phosphorus nanosheets (BP-Avidin
-
An overview on mRNA-based vaccines to prevent monkeypox infection J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-01 Mohammad Natami, Amirsasan Gorgzadeh, Arsalan Gholipour, Seyedeh Narges Fatemi, Nima Firouzeh, Maryam Zokaei, Saad Hasan Mohammed Ali, Hadis Kheradjoo, Somayeh Sedighi, Omid Gholizadeh, Shaylan Kalavi
The human monkeypox virus (Mpox) is classified as a member of the Poxviridae family and belongs to the Orthopoxvirus genus. Mpox possesses double-stranded DNA, and there are two known genetic clades: those originating in West Africa and the Congo Basin, commonly known as Central African clades. Mpox may be treated with either the vaccinia vaccination or the therapeutics. Modifying the smallpox vaccine
-
Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-01 Yixuan Wang, Feifei Li, Linshuang Mao, Yu Liu, Shuai Chen, Jingmeng Liu, Ke Huang, Qiujing Chen, Jianrong Wu, Lin Lu, Yuanyi Zheng, Weifeng Shen, Tao Ying, Yang Dai, Ying Shen
Impaired collateral formation is a major factor contributing to poor prognosis in type 2 diabetes mellitus (T2DM) patients with atherosclerotic cardiovascular disease. However, the current pharmacological treatments for improving collateral formation remain unsatisfactory. The induction of endothelial autophagy and the elimination of reactive oxygen species (ROS) represent potential therapeutic targets
-
Correction: Natural ursolic acid based self-therapeutic polymer as nanocarrier to deliver natural resveratrol for natural therapy of acute kidney injury J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-03-01 Yuanpeng Nie, Liying Wang, Shengbo Liu, Chunlei Dai, Tianjiao Cui, Yan Lei, Xinru You, Xiaohua Wang, Jun Wu, Zhihua Zheng
Correction: Journal of Nanobiotechnology (2023) 21:484 https://doi.org/10.1186/s12951-023-02254-x In this article Yuanpeng Nie and Liying Wang should have been denoted as equally contributing authors. The original article [1] has been revised. Nie, Y., Wang, L., Liu, S. et al. Natural ursolic acid based self-therapeutic polymer as nanocarrier to deliver natural resveratrol for natural therapy of acute
-
Development of finely tuned liposome nanoplatform for macrophage depletion J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-29 Tae Hyeon Choi, Ran Ji Yoo, Ji Yong Park, Ji Yoon Kim, Young Chan Ann, Jeongbin Park, Jin Sil Kim, Kyuwan Kim, Yu Jin Shin, Yong Jin Lee, Kyo Chul Lee, Jisu Park, Hyewon Chung, Seung Hyeok Seok, Hyung-Jun Im, Yun-Sang Lee
Immunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously reported liposomal formulation-based drugs (Clodrosome® and m-Clodrosome®) are limited by their inconsistent size and therapeutic efficacy. Thus, we aimed to achieve consistent therapeutic effects by effectively depleting macrophages with uniform-sized liposomes
-
Correction: Polydopamine-assisted aptamer-carrying tetrahedral DNA microelectrode sensor for ultrasensitive electrochemical detection of exosomes J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-28 Bowen Jiang, Tenghua Zhang, Silan Liu, Yan Sheng, Jiaming Hu
Correction: Journal of Nanobiotechnology (2024)22:55 https://doi.org/10.1186/s12951-024-02318-6 Following publication of the original article, details for affiliations of all authors were incorrectly given as: 1 MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University
-
Correction: Endothelial cell-derived exosomes boost and maintain repair-related phenotypes of Schwann cells via miR199-5p to promote nerve regeneration J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-28 Jinsheng Huang, Geyi Zhang, Senrui Li, Jiangnan Li, Wengang Wang, Jiajia Xue, Yuanyi Wang, Mengyuan Fang, Nan Zhou
Correction to: Journal of Nanobiotechnology (2023) 21:10 https://doi.org/10.1186/s12951-023-01767-9 Following publication of the original article [1], the authors identified an error in EXO-1 μg/mL group (the colony formation of SCs), in Fig. 2D. The complete corrected Fig. 2 is given below. The original article [1] has been corrected. Huang J, Zhang G, Li S, Li J, Wang W, Xue J, Wang Y, Fang M, Zhou
-
Multifunctional biomimetic hydrogel dressing provides anti-infection treatment and improves immunotherapy by reprogramming the infection-related wound microenvironment J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-28 Xiaogang Bao, Shicheng Huo, Zhenhua Wang, Shengyan Yang, Linyun Dou, Yifei Liu, Jian Huang, Chang Cai, Bin Fang, Guohua Xu
The advancement of biomaterials with antimicrobial and wound healing properties continues to present challenges. Macrophages are recognized for their significant role in the repair of infection-related wounds. However, the interaction between biomaterials and macrophages remains complex and requires further investigation. In this research, we propose a new sequential immunomodulation method to enhance
-
A novel extracellular vesicles production system harnessing matrix homeostasis and macrophage reprogramming mitigates osteoarthritis J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-28 Tianqi Wang, Hongqi Zhao, Yi Zhang, Yanshi Liu, Jialin Liu, Ge Chen, Ke Duan, Zhong Li, Hoi Po James Hui, Jiyuan Yan
Osteoarthritis (OA) is a degenerative disease that significantly impairs quality of life. There is a pressing need for innovative OA therapies. While small extracellular vesicles (sEVs) show promising therapeutic effects against OA, their limited yield restricts clinical translation. Here, we devised a novel production system for sEVs that enhances both their yield and therapeutic properties. By stimulating
-
Minicells as an Escherichia coli mechanism for the accumulation and disposal of fluorescent cadmium sulphide nanoparticles J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-27 Felipe Valenzuela-Ibaceta, Nicolás Torres-Olea, Javiera Ramos-Zúñiga, Claudio Dietz-Vargas, Claudio A. Navarro, José M. Pérez-Donoso
Bacterial biosynthesis of fluorescent nanoparticles or quantum dots (QDs) has emerged as a unique mechanism for heavy metal tolerance. However, the physiological pathways governing the removal of QDs from bacterial cells remains elusive. This study investigates the role of minicells, previously identified as a means of eliminating damaged proteins and enhancing bacterial resistance to stress. Building
-
Correction: Encapsulation of the dual FLAP/mPEGS‑1 inhibitor BRP‑187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-27 Blerina Shkodra, Christian Kretzer, Paul M. Jordan, Paul Klemm, Andreas Koeberle, David Pretzel, Erden Banoglu, Stefan Lorkowski, Maria Wallert, Stephanie Höppener, Steffi Stumpf, Antje Vollrath, Stephanie Schubert, Oliver Werz, Ulrich S. Schubert
Correction: J Nanobiotechnol (2020) 18:73 https://doi.org/10.1186/s12951-020-00620-7 In this article the author name Blerina Shkodra was incorrectly written as Blerina Shkodra-Pula. The original article [1] has been revised. Shkodra B, Kretzer C, Jordan PM, Klemm P, Koeberle A, Pretzel D, Banoglu E, Lorkowski S, Wallert M, Höppener S, Stumpf S, Vollrath A, Schubert S, Werz O, Schubert US. Encapsulation
-
Inhalable hybrid nanovaccines with virus-biomimetic structure boost protective immune responses against SARS-CoV-2 variants J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-27 Shuqi Wang, Peiyang Ding, Lingli Shen, Daopeng Fan, Hanghang Cheng, Jian Huo, Xin Wei, Hua He, Gaiping Zhang
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with different antigenic variants, has posed a significant threat to public health. It is urgent to develop inhalable vaccines, instead of injectable vaccines, to elicit mucosal immunity against respiratory viral infections. We reported an inhalable hybrid nanovaccine (NVRBD-MLipo) to boost protective immunity against SARS-CoV-2 infection
-
Highly sensitive SERS platform for pathogen analysis by cyclic DNA nanostructure@AuNP tags and cascade primer exchange reaction J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-26 Yunju Xiao, Shihua Luo, Jiuxiang Qiu, Ye Zhang, Weijiang Liu, Yunhu Zhao, YiTong Zhu, Yangxi Deng, Mengdi Lu, Suling Liu, Yong Lin, Aiwei Huang, Wen Wang, Xuejiao Hu, Bing Gu
The capacity to identify small amounts of pathogens in real samples is extremely useful. Herein, we proposed a sensitive platform for detecting pathogens using cyclic DNA nanostructure@AuNP tags (CDNA) and a cascade primer exchange reaction (cPER). This platform employs wheat germ agglutinin-modified Fe3O4@Au magnetic nanoparticles (WMRs) to bind the E. coli O157:H7, and then triggers the cPER to generate
-
Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-23 Zhengang Ding, Zineng Yan, Xun Yuan, Guangzhao Tian, Jiang Wu, Liwei Fu, Han Yin, Songlin He, Chao Ning, Yazhe Zheng, Zhichao Zhang, Xiang Sui, Libo Hao, Yuting Niu, Shuyun Liu, Weimin Guo, Quanyi Guo
Due to its unique structure, articular cartilage has limited abilities to undergo self-repair after injury. Additionally, the repair of articular cartilage after injury has always been a difficult problem in the field of sports medicine. Previous studies have shown that the therapeutic use of mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) has great potential for promoting cartilage
-
NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-19 Wenling Li, Huan Xin, Wenjuan Gao, Pengjun Yuan, Feixue Ni, Jingyi Ma, Jingrui Sun, Jianmin Xiao, Geng Tian, Lu Liu, Guilong Zhang
The formation of blood vessel system under a relatively higher Cu2+ ion level is an indispensable precondition for tumor proliferation and migration, which was assisted in forming the tumor immune microenvironment. Herein, a copper ions nano-reaper (LMDFP) is rationally designed not only for chelating copper ions in tumors, but also for combination with photothermal therapy (PTT) to improve antitumor
-
M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-19 Yufan Qian, Genglei Chu, Lei Zhang, Zhikai Wu, Qiuyuan Wang, Jiong Jiong Guo, Feng Zhou
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified. Exosomes were subjected to microRNA (miRNA) sequencing and bioinformatic analysis, and differentially expressed miRNAs were verified. miR-26b-5p target genes were confirmed through target-site mutation combined with
-
A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-19 Haribalan Perumalsamy, Sri Renukadevi Balusamy, Johan Sukweenadhi, Sagnik Nag, Davoodbasha MubarakAli, Mohamed El-Agamy Farh, Hari Vijay, Shadi Rahimi
Moringa oleifera is one of the popular functional foods that has been tremendously exploited for synthesis of a vast majority of metal nanoparticles (NPs). The diverse secondary metabolites present in this plant turn it into a green tool for synthesis of different NPs with various biological activities. In this review, we discussed different types of NPs including silver, gold, titanium oxide, iron
-
Correction: Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-19 Zijian Su, Yibo Zhang, Jieqiong Cao, Yuanmeng Sun, Yuling Cai, Bihui Zhang, Liu He, Zilei Zhang, Junye Xie, Qilin Meng, Lin Luo, Fu Li, Jingsheng Li, Jinting Zhang, Xiaojia Chen, An Hong
Correction: Journal of Nanobiotechnology (2023) 21:55 https://doi.org/10.1186/s12951-023-01812-7 Following publication of the original article [1], the authors identified an incorrect statement about the origin of SZ95 human sebaceous gland cells in the cells and cell culture. Therefore, in the cells and cell culture, the origin of SZ95 human sebaceous gland cells should be revised to “SZ95 human sebaceous
-
The oncolytic bacteria-mediated delivery system of CCDC25 nucleic acid drug inhibits neutrophil extracellular traps induced tumor metastasis J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-19 Li-na Liu, Chen Chen, Wen-jie Xin, Qiang Li, Chao Han, Zi-chun Hua
Neutrophil extracellular traps (NETs), antibacterial weapons of neutrophils (NEs), have been found to play a crucial role in cancer metastasis in recent years. More and more cancer research is focusing on anti-NETs. However, almost all anti-NETs treatments have limitations such as large side effects and limited efficacy. Therefore, exploring new anti-NETs therapeutic strategies is a long-term goal
-
Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-19 Martina Trentini, Ilaria Zanolla, Elena Tiengo, Federica Zanotti, Eduardo Sommella, Fabrizio Merciai, Pietro Campiglia, Danilo Licastro, Margherita Degasperi, Luca Lovatti, Massimo Bonora, Alberto Danese, Paolo Pinton, Barbara Zavan
Plant-derived nanovesicles (PDNVs) are a novelty in medical and agrifood environments, with several studies exploring their functions and potential applications. Among fruits, apples (sp. Malus domestica) have great potential as PDNVs source, given their widespread consumption, substantial waste production, and recognized health benefits. Notably, apple-derived nanovesicles (ADNVs) can interact with
-
Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-18 Yan Wang, Xiao Zhang, Hua Yue
Two-dimensional nanomaterials (2D NMs), characterized by a large number of atoms or molecules arranged in one dimension (typically thickness) while having tiny dimensions in the other two dimensions, have emerged as a pivotal class of materials with unique properties. Their flat and sheet-like structure imparts distinctive physical, chemical, and electronic attributes, which offers several advantages
-
Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-17 Yu Fu, Yuan-lin Zhang, Rong-qi Liu, Meng-meng Xu, Jun-ling Xie, Xing-liao Zhang, Guang-ming Xie, Yao-ting Han, Xin-Min Zhang, Wan-ting Zhang, Jing Zhang, Jun Zhang
The transplantation of exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic intervention for the treatment of neurodevelopmental disorders (NDDs), as well as autism spectrum disorder (ASD). Nevertheless, the efficacy of hADSC exosome transplantation for ASD treatment remains to be verified, and the underlying mechanism of
-
Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying miR-146a-5p J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-16 Dongdong Lu, Yisi Liu, Luyuan Kang, Xiangyu Zhang, Jie Hu, Hao Ye, Bingxu Huang, Yujun Wu, Jinbiao Zhao, Zhaolai Dai, Junjun Wang, Dandan Han
The intestinal development in early life is profoundly influenced by multiple biological components of breast milk, in which milk-derived extracellular vesicles (mEVs) contain a large amount of vertically transmitted signal from the mother. However, little is known about how maternal fiber-rich diet regulates offspring intestinal development by influencing the mEVs. In this study, we found that maternal
-
Correction: Antifungal activity of copper oxide nanoparticles derived from Zizyphus spina leaf extract against Fusarium root rot disease in tomato plants J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-16 Sozan E. El-Abeid, Mohamed A. Mosa, Mohamed A. M. El-Tabakh, Ahmed M. Saleh, Mohamed A. El-Khateeb, Maha S. A. Haridy
Correction: Journal of Nanobiotechnology (2024) 22:28 https://doi.org/10.1186/s12951-023-02281-8 Following publication of the original article [1], it was noted due to a typesetting error the figures and tables were positioned incorrectly in the PDF version of the article. Figure 1: The incorrect position is: Page 7 The correct position is: Page 8 " after title: Green synthesis of CuO Zs NPs” Figure 2:
-
Recent advances in two-dimensional nanomaterials for sustainable wearable electronic devices J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-15 Jing Hu, Mingdong Dong
The widespread adoption of smart terminals has significantly boosted the market potential for wearable electronic devices. Two-dimensional (2D) nanomaterials show great promise for flexible, wearable electronics of next-generation electronic materials and have potential in energy, optoelectronics, and electronics. First, this review focuses on the importance of functionalization/defects in 2D nanomaterials
-
Exosomes secreted by Fusobacterium nucleatum-infected colon cancer cells transmit resistance to oxaliplatin and 5-FU by delivering hsa_circ_0004085 J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-15 Bingqing Hui, Chenchen Zhou, Yetao Xu, Rui Wang, Yuwen Dong, Yirui Zhou, Jie Ding, Xiao Zhang, Jian Xu, Yanhong Gu
A large number of Fusobacterium nucleatum (Fn) are present in colorectal cancer (CRC) tissues of patients who relapse after chemotherapy, and Fn has been reported to promote oxaliplatin and 5-FU chemoresistance in CRC. Pathogens such as bacteria and parasites stimulate exosome production in tumor cells, and the regulatory mechanism of exosomal circRNA in the transmission of oxaliplatin and 5-FU chemotherapy
-
The quest for nanoparticle-powered vaccines in cancer immunotherapy J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-14 Zhe Sun, Hui Zhao, Li Ma, Yanli Shi, Mei Ji, Xiaodong Sun, Dan Ma, Wei Zhou, Tao Huang, Dongsheng Zhang
Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role in preventing illness by preparing the body's adaptive and innate immune responses to combat diseases. As our understanding of malignancies and their connection to the immune system improves, there has been a growing interest in priming the immune system to fight
-
Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1 J. Nanobiotechnol. (IF 10.2) Pub Date : 2024-02-12 Anna Łabędź-Masłowska, Luisa Vergori, Sylwia Kędracka-Krok, Elżbieta Karnas, Sylwia Bobis-Wozowicz, Małgorzata Sekuła-Stryjewska, Michał Sarna, Ramaroson Andriantsitohaina, Ewa K. Zuba-Surma
Mesenchymal stem cells/stromal cells (MSCs)-derived extracellular vesicles (EVs) mediate pro-regenerative effects in damaged ischemic tissues by regulating angiogenesis. MSCs-EVs modulate functions of cells including endogenous mature cells, progenitors and stem cells, resulting in restoration of blood flow. However, the mechanisms underlying such MSC-EV activity still remain poorly understood. The