Glycerol is a common by‐product of industrial biodiesel syntheses. Due to its properties, availability, and versatility, residual glycerol can be used as raw material in the production of high value‐added industrial inputs and outputs. In particular, products like hydrogen, propylene glycol, acrolein, epichlorohydrin, dioxalane and dioxane, glycerol carbonate, n‐butanol, citric acid, ethanol, butanol

Proteomic information revealed approximately 3923 proteins in Mycobacterium tuberculosis H37Rv (M. tuberculosis) genome of which around ∼25% of proteins are hypothetical proteins (HPs). The present work comprises computational approaches to identify and characterize the HPs of M. tuberculosis that symbolize the putative target for rationale development of a drug or anti‐tuberculosis strategy. Proteins

Neddylation, a posttranslational protein modification, refers to the specific conjugation of NEDD8 to substrates, which is of great significance to various biological processes. Besides members of the cullin protein family, other key proteins can act as a substrate for neddylation modification, which remarkably influences neurodevelopment and neurodegenerative diseases. Normal levels of protein neddylation

Acute myocardial infarction (AMI) is the heart attack happening when the blood flow is terminated to the heart muscles. C‐reactive protein (CRP) level is raising significantly in AMI patients after the onset of symptom; also, temporal variations of CRP in plasma of AMI patient have also been found. Quantifying the concentration of CRP helps to identify the condition associated with AMI. Plasmonic enzyme‐linked

Sepsis is a clinical condition caused by an uncontrolled response to an infection, leading to acute kidney injury (AKI) and an increased risk of mortality. Although life support and antibiotic therapy are available, the mortality rate remains high in patients with sepsis. The present study investigated the therapeutic effect of glutamine on

The objective of this work was to evaluate the biochemical characteristics of an enzymatic extract obtained from autochthonous fungus Aspergillus niger ITV02 and its application in the enzymatic hydrolysis of wheat straw and corn stubble pretreated by steam explosion. The enzymatic extract was obtained by submerged fermentation using delignified sweet sorghum bagasse as carbon source. The results obtained

Renal fibrosis results in the progressive renal dysfunction and leads to chronic kidney disease (CKD) and ultimately end‐stage renal disease. Asiaticoside was reported to regulate synaptopodin, desmin, nephrin and podocin levels in adriamycin‐induced nephropathy of rats. In this study, we found out that asiaticoside inhibited renal fibrosis in vitro and in vivo. Additionally, miR‐142‐5p was upregulated

Autophagy causes the breakdown of damaged proteins and organelles to their constituent components. The Phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in regulating the autophagic response of cells in reply to changing reactive oxygen species (ROS) levels. The PI3K α catalytic subunit inhibits autophagy while the β catalytic subunit promotes autophagy in response to changes in

Angiotensin‐converting enzyme (ACE) liable for the regulation of blood pressure was purified from human plasma by affinity chromatography. Impact of water and butanol extracts of Matricaria chamomilla L. (M. chamomilla) on purity ACE was examined. ACE was purified using the affinity chromatography method. The enzyme activity was evaluated at 345 nm by spectrophotometer. Extracts of M. chamomilla plant

Oxidative stress is to upregulate the pentose phosphate pathway (PPP). The PPP consists of two functionally branches, glucose‐6‐phosphate dehydrogenase (G6PD) and 6‐phosphogluconate dehydrogenase (6PGD). Glutathione reductase (GR) has a significant role in catalyzing an oxidized glutathione form into a reduced form. The purpose of this study is to investigate the effects of Brimonidine and Proparacaine

The arrival of novel health crisis by a novel member of coronavirus group named as SARS‐CoV‐2 by WHO took the whole world in global emergency by affecting 206 countries. The virus infects 205 countries with 86,839,226 confirmed cases, 61,565,949 recoveries and 1,876,243 deaths as on 6th January 2021. Evidences pointed out the fact that virus might first originated in bats in China and it takes only

Syndecan‐binding protein (SDCBP) has been reported to critically process a core role in tumorigenesis. The aim of this study was conducted to characterize a novel regulatory network of SDCBP in gastric carcinoma (GC) cells. Our findings indicated that overexpression of SDCBP promoted the proliferation of GC cell and increased PCNA expression. Moreover, the overexpression of SDCBP suppressed the apoptosis

Human plasminogen activator inhibitor‐1 (PAI‐1) is an important component of the coagulation system and has been recognized as a potential therapeutic target of diverse cardiovascular disorders. Previously, it was found that the extracts from the Chinese medicine Dracaena dragon blood have potent inhibitory activity against PAI‐1, but it is unclear which constituents directly participate in the inhibition

This study aims to clarify the function of TRPM8 in colon cancer liver metastasis. Firstly, TRPM8 expression was determined by Western blotting in colon cancer patients with/without liver metastasis. Secondly, colon cancer cells were grouped into Mock, siCON and siTRPM8 groups. Then a series of in‐vitro experiments were conducted. Lastly, CT26 cells were used to construct colon cancer liver metastasis

The measure of sorbitol in serum can act as a good indicator in the monitoring of the diabetic complications. To analyze the sorbitol level in serum medium, fluorometric enzymatic assay was performed. To remove the excess sorbitol from the body, proposed binding of sorbitol with caffeine was investigated. Their interaction in serum medium was studied and established by UV‐Vis, fluorescence spectrophotometry

The recent emergence of natural biopolymers as drug delivery vehicles is attributed to their biodegradability and less systemic toxicity. Muga silk nanoparticles were prepared using microwave radiolysis method and were characterized by FTIR, CD, XRD, and TEM. To find the applicability in the drug delivery system of these nanoparticle and to know the binding site(s), a computational study was carried

Recently, there has been a growing demand to develop portable devices for the fast detection of contaminants in food safety, healthcare, and environmental fields. Herein, two biosensing methods were designed by the use of NAD(P)H‐dependent TetX2 enzyme activity and thionine as an excellent electrochemical and colorimetric mediator/probe to monitor tetracycline (TC) in milk. The nano‐porous glassy carbon