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A peer-based strategy to overcome HPV vaccination inequities in rural communities: A physical distancing-compliant approach Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2021-01-01 Christine Finley; Matthew Dugan; Jan Carney; Wendy Davis; Thomas Delaney; Victoria Hart; Breena Holmes; Gary Stein; Robin Katrick; Holly Morehouse; Bernard Cole; Leslie Bradford; Maureen Boardman; Heidi Considine; Nancy Kaplan; Merideth Plumpton; Linda Schadler; Jennifer Smith; Kate McAllister
The human papilloma virus (HPV) vaccine is the world’s first proven and effective vaccine to prevent cancers in males and females when administered pre-exposure. Like most of the US, barely half of Vermont teens are up-to-date with the vaccination, with comparable deficits in New Hampshire and Maine. The rates for HPV vaccine initiation and completion are as low as 33% in rural New England. Consequently
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Dexmedetomidine inhibits inflammation to alleviate early neuronal injury via TLR4/NF- ?B pathway in rats with traumatic brain injury Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2021-01-01 Gui-Rong Huang; Feng-Guan Hao
Purpose: This study aims to explore the potential mechanism of dexmedetomidine in terms of inhibiting inflammation to alleviate early neuronal injury via TLR4/NF- κB pathway in rats with traumatic brain injury. Methods: The model of brain injury was established in rats. After the model was established, the rats were randomly divided into five groups: Sham, Sham + DEX, TBI, TBI + vehicle, and TBI +
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Effects of miR-362 in regulating the proliferation, invasion and apoptosis of gastric cancer by inhibiting the expression of tumor-promoting factor PRDM2 Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-12-01 Rui-Min Wu; Zhi-Jun Pei; Hua-Qiong Zhang; Yan Gao; Xiao-Yi Duan
Purpose: The high expression of positive regulatory domainzinc finger protein2 (PRDM2) is an important factor in inducing the formation and progression of gastric cancer. The current study was performed to explore the effect of micro-RNA-362 (miR-362) targeting PRDM2 on the proliferation and apoptosis of gastric cancer cells. Methods: The expression of miR-362 in gastric adenocarcinoma and normal gastric
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Expression of CEACAM1 and CD105 in renal cell carcinoma and its correlation with microvessle density Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-12-01 Zhao-Peng Kang; Li-Xin Wang; Jun Liu; Hai Ouyang; Sheng Xie; Yan Tan
Objective To investigate expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and endoglin (CD105) in renal cell carcinoma (RCC), and their potential role in predicting the tumor growth and progression. Method Total of 47 RCC specimens and 15 adjacent normal kidney tissues were obtained. Expression of CEACAM1 and CD105 was assessed by immunohistochemistry. Microvessel density
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Knockdown of CDCA5 inhibits cell proliferation, migration and invasion, and induces apoptosis of prostate cancer cells Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-11-01 Yue Chong; Li Xue
Background: Prostate cancer (PC) is the most common form of cancer in males and accounts for high cancer related deaths. CDCA5 may be a useful marker for predicting tumor metastasis and therapeutic target for the treatment of PC patients. In this study, we investigated the role of CDCA5 in prostate cancer progression. Immunohistochemistry was performed on 20 prostate cancer tissues. Method: We performed
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Epigenetics and its ethical implications Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-11-01 Domenico RIBATTI
The one who first coined the term epigenetics defining it as "the branch of biology that studies the causal interactions between genes and their products and creates a phenotype" was the biologist Conrad Waddington. The molecular basis of epigenetics is complex. Epigenetic changes are rapid, functional, non-structural, reversible, and partly transmissible DNA changes from one generation to the next
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Association between miRNAs Expression and Signaling Pathways of Oxidative Stress in Polycystic Ovary Syndrome. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-07-01 Alireza Mafi,Naghmeh Mirhosseini,Esmat Aghadavod,Moghaddaseh Jahanshahi,Zatollah Asemi
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder which its prevalence directly depends on the diagnostic criteria used to define this syndrome. Recently, many different factors have been introduced as predisposing factors in the high incidence of PCOS, one of them is microRNAs. MicroRNAs are short non-coding RNAs that can regulate target gene expression through transcriptional
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Molecular Mechanisms Linking Nutrition to Metabolic Homeostasis: An Overview Picture of Current Understanding Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Carla Pignatti; Stefania D'Adamo; Flavio Flamigni; Silvia Cetrulllo
Increasing evidence supports the notion that in humans many pathological conditions including obesity, metabolic syndrome, and type 2 diabetes are closely related to the amount and quality of each nutritional component and to an impairment of the metabolic homeostatic mechanisms of their utilization. Cell signaling pathways that sense the availability of nutrients and the energy status of the cells
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Relationship between CYP17A1-Mediated DNA Demethylation and Proliferation, Invasion and Metastasis of Glioma Cells Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Linghu Meng; Wei Lv; Yi Zhou
Objective: We investigated the relationship between CYP17A1-mediated DNA demethylation and proliferation, invasion, and metastasis of glioma cells. Methods: The expression of CYP17A1 mRNA and protein in cells was determined by PCR and Western blot assays. The methylation status of CYP17A1 was detected by the MSP method. Cell proliferation and apoptosis were detected by MTT assays and flow cytometry
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Bioactivity-Guided Isolation and Identification of Anti-adipogenic Constituents from the n-Butanol Fraction of Cissus quadrangularis Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Rabail Hassan Toor; Zainab Nasir Khan; Maira Tariq; Raazia Tassaduq; Qurratulann Afza Gardner; Waheed-uz-Zaman; Jane B. Lian; Janet L. Stein; Gary S. Stein; Abdul Rauf Shakoori
Obesity is marked by the buildup of fat in adipose tissue that increases body weight and the risk of many associated health problems, including diabetes and cardiovascular disease. Treatment options for obesity are limited, and available medications have many side effects. Thus there is a great need to find alternative medicines for treating obesity. This study explores the anti-adipogenic potential
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Minireview: The Introduction of COVID-19 and Microvascular Disease−Introduction of COVID-19 and the Relationship between Its Receptor and Diabetic Vascular Complications Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Ying Song; Qizhuang Ma; Peiyao Lin; Dongxu Qin; Dongze Lu; Xuli Fan
In December of 2019, a novel coronavirus, which is SARS-CoV-2, broke out in the world and caused tremendous human and financial losses. According to a descriptive study by the relative hospital about the epidemiological and clinical features of 52 critically ill patients, the expert panel found that people with cardiovascular disease and diabetes comprise a large proportion of the patients with chronic
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The Critical Role of the miR-21−MEG2 Axis in Colorectal Cancer Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Zengtao Bao; Shanting Gao; Baoming Zhang; Wenchao Shi; Aimin Li; Qingshui Tian
Protein tyrosine phosphatase MEG2 (MEG2/PTPN9), a classic tyrosine-specific protein tyrosine phosphatase (PTP), is involved in the progression of liver, breast, and gastric cancers. However, the function and regulation of MEG2 in colorectal cancer (CRC) still remain unclear. In this study, we investigated the expression of MEG2 in CRC and found that MEG2 was downregulated in human CRC tissues compared
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The Boundary between Normal and Pathological Conditions Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Domenico Ribatti
There is clinical and experimental evidence that in biomedicine, the limit between what we consider normal and what we consider pathological is not always so clear and absolute. Conditions may arise in which, apparently without any explanation, one passes from one condition to another. A key role is played by changes that occur in the microenvironment surrounding a cell population. The terms normal
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The Significance of Detection of Circulating Tumor Cells and Beclin1 in Peripheral Blood of Patients with Renal Cell Carcinoma Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Peng Zhang; Zhenlong Wang; Xiaojie Yang; Ke Gao; Mingrui Li; Tie Chong
Aim: In this study, the correlation between the circulating tumor cells (CTCs), clinical and pathological status, Beclin1 expression, and the prognosis of patients with renal cell carcinoma were studied. Methods: The patients with renal cancer were tested every 3 months for 2 years, and once every 6 months after 2 years by using CanPatrol-ITMCTCs detection technology. The expression of Beclin1 in different
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The Biology of Toll-Like Receptor 9 and Its Role in Cancer Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Badr Alzahrani
Toll-like receptor 9 (TLR9) plays a fundamental role in innate immune responses through pathogen-associated and danger-associated molecular pattern recognition. Ligand recognition by TLR9 results in activation of several signaling pathways, including those involving nuclear factor-kappa B, mitogen-activated protein kinases, and interfer-on-regulatory factors, which promote secretion of proinflammatory
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Meta-Analysis of CTLA-4 +49 Gene Polymorphism and Susceptibility to Graves' Disease Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Fengli Huang; Qin He; Xiaoli Jiao; Hong Zhang; Qing Chang
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) plays an important role in the initiation and development of Graves' disease (GD), especially CTLA-4 +49A/G polymorphism and genetic susceptibility to GD. However, the current conclusions are consistent. Therefore, this study adopted meta-analysis method to assess the exact correlation between this polymorphism and GD risk. Methods: Literature searches
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François Jacob, Lysogeny, and the Development of the Operon Model Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Domenico Ribatti
This article summarizes the fundamental contribution of Francois Jacob in the field of molecular biology. Jacob was one of the handful of scientists who initiated the revolution in biology that took place in the second half of the 20th century. In their landmark publication of 1961, entitled "Genetic Regulatory Mechanisms in the Synthesis of Proteins", François Jacob and Jacques Monod presented a model
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Prognostic Value of Differentially Expressed LncRNAs in Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Dilihumaer Tuluhong; Wangmu Dunzhu; Jingjie Wang; Tao Chen; Hanjun Li; Qiurong Li; Shaohua Wang
Breast cancer is the most common cancer in women worldwide and can be classified into multiple subtypes, including triple-negative breast cancer (TNBC). TNBC is more aggressive than other types of breast cancer and has a poor prognosis. However, excluding chemotherapy, the treatment of TNBC does not involve targeted therapy. The dysregulated expression of lncRNAs plays a vital role in the development
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Hippo Kinases MST1/2 Regulate Immune Cell Functions in Cancer, Infection, and Autoimmune Diseases Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Yuexin Wang; Anna Jia; Yejin Cao; Xuelian Hu; Yufei Wang; Qiuli Yang; Yujing Bi; Guangwei Liu
Mammalian STE20-like protein kinases (MST), including MST1, MST2, MST3, and MST4, belong to the germinal center kinase (GCK) family. Kinase MST1/2 is an important component of the Hippo pathway in regulating cell proliferation, tissue homeostasis, and organ development. Recent studies have shown that Hippo kinase MST1/2 plays a crucial role in immune-associated diseases, which has attracted extensive
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Molecular Cloning and Characterization of an Acidic Polygalacturonase from Grapes and Its Potential in Industry Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Zahra Nazir; Riffat Chohan; Malik Siddique Mahmood; Hafiz Muzzammel Rehman; Roquyya Gul; Mahjabeen Saleem
Pectinase enzymes from different plants have many possible biotechnological applications in various industries. Considering industrial significance of pectinolytic enzymes, the polygalacturonase (PG) gene from grapes was cloned into Escherichia coli DH5α using pTZ57R/T vector. Homologous sequences established a close link to Vitis vinifera. Conserve domain analysis predicted PLN02218 domain belongs
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Dynamic Signature of tRNA-Derived Small RNAs in Cancer Pathogenesis as a Promising Valuable Approach Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Somayeh Vafaei; Fahimeh Fattahi; Maryam Sahlolbei; Jafar Kiani; Ayna Yazdanpanah; Zahra Madjd
Aim: Noncoding RNAs are a cluster of RNAs that do not encode functional proteins. Instead, they are incorporated into DNA structure and regulate gene expression. Of these two classes, transfer RNAs (tRNAs) belong to the former, and small RNAs (sRNAs) belong to the latter. Recently, tRNA-derived small RNAs (tsRNAs/tDRs) were discovered among small noncoding RNAs, as the newly discovered regulatory small
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Laser Disrupts AKT Hydrogen Network in Cancer. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Ziv Radisavljevic
The cancer metastatic process is supported by the strong AKT hydrogen bond network. This network is formed by positive feedback loops generated in the cancer hypoxic microenvironment through the genomic AKT signaling locus. Laser paired photons disrupt the hydrogen network of the AKT active site by laser catalyzed fusion inducing the disappearance of the malignant phenotype. Paired photons increase
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Strong Correlation between the Expression of CHEK1 and Clinicopathological Features of Patients with Multiple Myeloma. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Xiao-Ping Liu,Qiao Huang,Xiao-Hong Yin,Xiang-Yu Meng,Yue Cao,Xin-Hui Yan,Li He
Multiple myeloma (MM) is one of the most common malignancies, and the clinical outcome of patients with MM remains poor. Our objective is to screen biomarkers correlated with clinicopathological features and survival of patients with MM. A gene co-expression network was constructed to screen hub genes related to the three stages in the International Staging System (ISS) of MM. Functional analysis and
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Role of MicroRNAs in Establishing Latency of Human Immunodeficiency Virus. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Muhammad Munam Mustafa Bukhari,Iqra Mir,Muhammad Idrees,Samia Afzal,Muhammad Shahid
Acquired immunodeficiency syndrome (AIDS) emerged as an epidemic in Africa in 1981, and now it has become a most destructive global pandemic. Human immunodeficiency virus (HIV) is responsible for the pathogenesis of AIDS, and it is usually transmitted through unsafe sexual activities. HIV is a lentivirus that can remain latent in the host cells for a long period, and it has various mechanisms to establish
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Drug Resistance in Hepatitis C Virus: Future Prospects and Strategies to Combat It. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Iqra Almas,Samia Afzal,Hamna Imtiaz,Mahrukh Akbar Shaheen,Muhammad Daud,Anam Saghir,Iram Amin,Muhammad Shahid,Muhammad Idrees
Induction of highly pathogenic hepatitis C virus (HCV) causes chronic hepatitis round the world. This virus is easily prone to developing resistance against antiviral drugs because of two viral polymerases that do not possess the proofreading and overlapping reading frame abilities. There is more than one explanation for how this virus builds up resistance against antiviral drug treatments. Assays
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Role of Oxidative Stress and Antioxidant Defense Biomarkers in Neurodegenerative Diseases. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Uzma Saleem,Shakila Sabir,Sammia Gul Niazi,Muhammad Naeem,Bashir Ahmad
Oxidative stress is caused by an imbalance in a redox system. It may involve either excessive production of reactive oxygen species or dysfunction of the antioxidant defense system. Unlike other viscera, the brain is especially highly susceptible to oxidative damage because of it requires a high oxygen level and contains an abundance of peroxida-tion-susceptible lipid cells. Oxidative stress is among
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Malignant Melanoma: Skin Cancer-Diagnosis, Prevention, and Treatment. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Bilal Ahmed,Muhammad Imran Qadir,Saba Ghafoor
Melanoma is a skin cancer caused by a malignancy of melanocytes. Incidence of melanoma is rapidly increasing worldwide, which results in public health problems. Primary extracutaneous melanomas can be ocular, gastrointestinal, mucosal, leptomeningeal, genitourinary, and lymphatic. The relationship between exposure to ultraviolet (UV) light and development of melanoma is intensively acute and complex
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Association of Interleukin 10 (IL-10) Gene with Type 2 Diabetes Mellitus by Single Nucleotide Polymorphism of Its Promotor Region G/A 1082. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Shagufta Naz,Nida Shafique,Saima Sharif,Farkhanda Manzoor,Sher Zaman Saifi,Sabika Firasat,Haiba Kaul
Interleukin 10 (IL-10) is an anti-inflammatory cytokine with lower circulating levels in patients with type 2 diabetes mellitus (T2DM). Cytokines such as IL-10 downregulate the production of pro-inflammatory cytokines, which impair proper function of insulin. So any mutation in the IL-10 gene results in increased production of proinflammatory cytokines, which in turn affect insulin action and cause
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Clinical Association between Phospho-AKT Expression with Clinicopathological Characteristics of Gastrointestinal Cancer Patients: A Meta-Analysis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Hossein Abdeahad,Afsane Bahrami,Majid Khazaei,Gordon A Ferns,Marjan Erfani,Hamid Fiuji,Mehran Pahirzad,Amir Avan,Seyed Mahdi Hassanian Mehr
Deregulation of AKT (protein kinase B) is frequently observed in human malignancies including gastrointestinal (GI) cancers. Here we have reviewed the association between AKT phosphorylation (activation) and clinical and pathological characteristics of patients with GI cancer. Articles in the EMBASE, PubMed, Cochrane Library, and Web of Science databases were searched up to July 2018. Eighteen studies
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Pharmacological and Genomic Approaches in Management of Cystic Fibrosis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Muhammad Imran Qadir,Iqra Ali Yameen
Cystic fibrosis (CF) is an inherited recessive autosomal disorder that affects the lungs, the digestive system, and secretory glands. It is a lethal condition caused by a mutation in the gene cystic-fibrosis-transmembrane-conductance- regulator (CFTR), which leads to defects in ion channels and results in obstruction of mucus in airway channels. Unbalanced ion exchange causes impaired water transport
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Paradoxical Role of Dengue Virus Envelope Protein Domain III Antibodies in Dengue Virus Infection. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Sheeza Ali,Samia Afzal,Muhammad Zubair Yousaf,Muhammad Shahid,Iram Amin,Muhammad Idrees,Ayma Aftab
Every year, approximately 100 million individuals are infected with dengue viral infections. Severe dengue infection, characterized as dengue hemorrhagic fever, leads to loss of intravascular fluids and severe bleeding. During dengue virus (DENV) secondary infection, the body produces neutralizing antibodies that cause a strong immune response, resulting in severe hemolysis and plasma leakage. DENV
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The Prognostic Value of Small Noncoding microRNA-21 Expression in the Survival of Cancer Patients: A Meta-Analysis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Maryam Moradi Binabaj,Afsane Bahrami,Majid Khazaei,Amir Avan,Gordon A Ferns,Saman Soleimanpour,Mikhail Ryzhikov,Seyed Mahdi Hassanian
microRNA-21 (miR-21) is a small noncoding RNA that regulates gene expression in different types of human malignancies. The potential prognostic value of miR-21 in cancer progression is controversial. This meta-analysis includes 76 studies of 10,213 cancer patients to test miR-21 prognostic value in various human cancers. We obtain hazard ratios (HRs) and corresponding 95% confidence intervals (CIs)
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Association of Interleukin 28B Polymorphism with Clearance of Hepatitis C Virus: A Mini Review. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Mahrukh Shaheen,Samia Afzal,Bushra Khubaib,Iram Amin,Muhammad Shahid,Muhammad Idrees
The highly infectious hepatitis C virus (HCV) is the major cause of chronic hepatitis around the globe. Approximately 3% of the world's population has been affected by both chronic and acute HCV. In this study, we highlight the relationship between single-nucleotide proteins (SNPs) and interleukin (IL) IL28B on chromosome 19 with the treatment response of chronic HCV infection along with its sustained
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Association of ERCC1 and ERCC2 Gene Polymorphisms with Pancreatic Cancer Risk: A Meta-Analysis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Fuyi Xie,Qi Sun,En Zhang,Yinyu Mu
In this meta-analysis, all relative literature was retrieved through the Embase and PubMed databases. Moreover, the Stata 12.0 software package was applied to calculate the pooled odds ratio (OR) of the 95% confidence interval (CI). A total of seven studies was identified to analyze the relation between ERCC1 and ERCC2 gene polymorphisms and pancreatic cancer risk. The results showed that ERCC2 rs13181
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CRISPR/Cas: A Successful Tool for Genome Editing in Animal Models. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Bilal Ahmed,Mashaal Arif,Muhammad Imran Qadir
CRISPR/Cas9 is an innovative molecular tool that is utilized in advanced biological applications. This review focuses on modifying the genomes of a wide range of animals by CRISPR/Cas9 for greater usability and higher efficiency, providing an overview of the function and mechanism of this system and the utilization of this system for medicinal research. The type II CRISPR-Cas system is found in the
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Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Mohammad Altamish,Rajiv Dahiya,Avinash Kumar Singh,Anurag Mishra,Alaa A A Aljabali,Saurabh Satija,Meenu Mehta,Harish Dureja,Parteek Prasher,Poonam Negi,Deepak N Kapoor,Rohit Goyal,Murtaza M Tambuwala,Dinesh Kumar Chellappan,Kamal Dua,Gaurav Gupta
Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to
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Association of Polymorphisms of Mismatch Repair Genes hMLHI and hMSH2 with Breast Cancer Susceptibility: A Meta-Analysis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Qiong Zhang,Ya-Nan Wang,Xi-Yao Wu,Xu-Dong Chen,Pei-Qiang Liu,Xiao-Shuang Li
This article serves to evaluate the association of polymorphisms of mismatch repair genes (hMLH1 and hMSH2) with breast cancer (BC) susceptibility through a meta-analysis. Our methods involved extensive research in Chinese and English databases that examined the association of hMLH1 and hMSH2 polymorphisms with susceptibility to BC, strictly abiding by established inclusion and exclusion criteria.
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The Role of Lysophosphatidic Acid Receptors in Ovarian Cancer: A Minireview. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Ran Cui,Huimin Bai,Guangming Cao,Zhenyu Zhang
Lysophosphatidic acid (LPA) is a bioactive lipid component of ovarian cancer activating factor, which is present at a high concentration in the ascitic fluid and plasma of patients with ovarian cancer. A group of six lysophosphatidic acid receptors (LPARs), LPAR1 through LPAR6, which belong to the G protein−coupled receptor superfamily (GPCR), mediate cellular activities of LPA and activates a series
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Inhibition of Hepatitis B Virus with the Help of CRISPR/Cas9 Technology. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Sadaf Noor,Akhtar Rasul,Muhammad Shahid Iqbal,Bilal Ahmed,Muhammad Sajid Hamid Akash,Muhammad Imran Qadir
Hepatitis B infection caused by hepatitis B virus (HBV) is a serious health issue worldwide. Existing therapeutic strategies hardly eradicate HBV infections, and they fail to attain complete cure. Advanced treatment strategies are urgently needed to successfully terminate further spread of HBV infection and eliminate hidden reservoirs of virus. Recently, a novel RNA-guided gene editing tool, known
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The Relationship between HDAC3 and Malignant Tumors: A Mini Review. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Lou Tong,Haotian Liang,Huiyu Zhuang,Chongdong Liu,Zhenyu Zhang
Histone deacetylases 3 (HDAC3) is a member of the histone deacetylases family. This family is associated with cellular physiological function, such as signal transduction, cell cycle, proliferation, apoptosis, and cardiac development. HDAC3 plays an important role in the progression of malignant tumors, especially in terms of proliferation, apoptosis, metastasis, angiogenesis, and anticancer drug resistance
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Betalains: Potential Drugs with Versatile Phytochemistry. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Syed Farhad Hussain Naqvi,Muhammad Husnain
Currently, the demand for natural colorants is increasing instead of synthetic colorants for foodstuff, because they are harmless to human health. Betalain is group of compounds containing nitrogen and water soluble pigment. Betalain is classified into two main classes, betacyanin which is the condensation of betalamic acid with cyclo-DOPA and betaxanthin which is the conjugation of amino acid or amines
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The Identification of Key Gene Expression Signature in Prostate Cancer. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Yu Huang,Qi Cao,Zhengshuai Song,Hailong Ruan,Keshan Wang,Ke Chen,Xiaoping Zhang
Prostate cancer (PCa) is one of the most common malignancies affecting men's health worldwide. The aim of this study is to identify key genes and their regulatory networks and evaluate the usefulness of these genes on diagnosis of and prognosis for prostate cancer. The gene expression microarray dataset GSE55945 was downloaded for analysis. The differentially expressed genes (DEGs) were accessed with
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Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Keshav Thakur,Abha Tiwari,Kaushal Sharma,Shweta Modgil,Radhika Khosla,Akshay Anand
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is characterized with progressive muscle atrophy. We have attempted to establish the link between angiogenesis and cellular survival in the pathogenesis of ALS by compiling evidence described in various scientific reports. The phenotypes of human ALS have earlier been captured in the mutant SOD1 mice as well as by targeted deletion
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MTHFR-C677T Gene Polymorphism and Susceptibility to Acute Lymphoblastic Leukemia in Children: A Meta-Analysis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Yu Li,Yu-Xin Pei,Li-Na Wang,Cong Liang,Yan-Lai Tang,Xiao-Li Zhang,Li-Bin Huang,Xue-Qun Luo,Zhi-Yong Ke
BACKGROUND The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) and childhood acute lymphoblastic leukemia (ALL) is inconsistent. OBJECTIVE To explore the relationship between MTHFR-C677T polymorphism and susceptibility to childhood ALL. METHODS PubMed, EMBASE, Web of Science, CNKI, Wanfang, VIP, and other databases were searched from the establishment
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Lysosome AKT Targeting in Metastatic Cancer. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Ziv Radisavljevic
Metastatic cancer is caused by hyperactivated lysosomes. Such activation causes a fungus, Aspergillus fumigatus, to permanently activate the AKT gene network that controls the lysosome through positive feedback loops. Targeting such a network by the redox balance change, and with an antifungal medication eliminates the metastatic phenotype, the complexity and robustness of the cancer. This principal
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Manifestation and Pathogenesis of Sudden Infant Death Syndrome: A Review. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Jasndeep Kaler,Azhar Hussain,Stanley Lee
Historically known as "cot death," sudden infant death syndrome (SIDS) is one of the leading causes of postnatal death in infants. According to the Centers for Disease Control and Prevention in 2010, more than 2,000 U.S. infants died from SIDS. Sudden infant death syndrome is the unexplainable death of an infant, less than one year old, that is otherwise healthy. SIDS was first discovered in 1969,
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Identification of Hub Genes in Gastric Cancer with High Heterogeneity Based on Weighted Gene Co-Expression Network. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Zhe Dong,Shengnan Pei,Yan Zhao,Shuai Guo,Yue Wang
Intra-tumor heterogeneity (ITH) plays an important role in the therapeutic resistance and prognosis of gastric cancer (GC), but there are no effective methods to detect it. The purpose of this study was to apply the mutant-allele tumor heterogeneity (MATH) algorithm to reveal the relationship between ITH and clinical features, and to use weighted gene co-expression network analysis (WGCNA) to search
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PPAR-α Agonist Fenofibrate Ameliorates Oxidative Stress in Testicular Tissue of Diabetic Rats. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Habib Yaribeygi,Mohammad Taghi Mohammadi,Tannaz Jamialahmadi,Amirhossein Sahebkar
BACKGROUND Oxidative stress has the potential to induce impotence, especially in diabetic patients. Peroxisome proliferator-activated receptor alpha (PPAR-α) agonists can potentiate antioxidants in a wide variety of tissues. However, no available evidence exists showing a direct antioxidant effect on testicular tissue in the setting of diabetes. Therefore, the aim of this study was to evaluate whether
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Identification of Potential Core Genes in Immunoglobulin-Resistant Kawasaki Disease Using Bioinformatics Analysis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Yan Pan,Qihong Fan
Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) is a complex disease, leading to the damage of multiple systems. The pathogen that triggers this sophisticated disease is still unknown. The aim of this study was to identify gene signatures during IVIG-resistant KD and uncover their potential mechanisms. The gene expression profiles of GSE18606 were downloaded from the GEO database
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CRISPR-CAS Replacing Antiviral Drugs against HIV: An Update. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Rabia Hashmat,Muhammad Zubair Yousaf,Ziaur Rahman,Khalid Mahmood Anjum,Atif Yaqoob,Muhammad Imran
Various antiretroviral drugs do not kill or cure the human immunodeficiency virus (HIV) but do prevent the replication of the virus. The combination of antiretroviral drugs is known as highly active antiretroviral therapy (HAART). Current drug therapies effectively suppress HIV-1 replication but do not inactivate the provirus that persists in latent reservoirs. Guide RNA (gRNA)-directed CRISPR/Cas9
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Systematic Review: Models of Changes in Gene Expression of MTOR, MURF-1, and MAFBX in Rats and Mice. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Marcos Roberto Campos de Macêdo,Raphael Furtado Marques,Alanna Joselle Santiago Silva,Francisco Navarro,Antonio Coppi Navarro
INTRODUCTION Various pathologies and lifestyle factors, such as nutritional factors and physical exercises, can alter the gene expression of proteins related to synthesis and degradation. AIM We performed a systematic review of atrophy models, cancer models, burn models, sepsis models, cardiac insufficiency models, amino acid supplementation models, protein supplementation models, and miscellaneous
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CRISPR/CAS9-Mediated Antiviral Activity: A Tool to Combat Viral Infection. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Usman Ali Ashfaq,Hina Khalid
Viruses hijack host cellular receptors and functions for replication, thereby posing a complication in identifying therapeutic targets. The CRISPR/Cas 9 platform has revolutionized gene-editing modalities in a wide range of cells and organisms with high potential in therapeutics. Recently, it has been put to work targeting human pathogenic viruses that interrupt receptors and functions with viral replication
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An Insight into Primary Congenital Glaucoma. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Muhammad Umer Khan,Musabih Ul Qayyum Zia,Wajeeha Tabassum
Glaucoma is the second most prominent cause of impaired vision in the world. Over 60 million individuals are presently affected, and 12 million are sightless as a result. Primary congenital glaucoma (PCG) is a childhood disease that can lead to blindness in newborns and very young children. The rate of occurrence of PCG varies in different communities and across geographical boundaries, and its etiology
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Meiotic Behavior of Extra Sex Chromosomes in Patients with the 47,XXY and 47,XYY Karyotype and Its Ultimate Consequences for Spermatogenesis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Furhan Iqbal
Infertility is one of the most important and burning issues in present times, as a marked increase in the frequency of infertile cases has been observed all over the world. Chromosomal aneuploidy is among the known factors associated with infertility, and among sex chromosome aneuploidies, 47,XXY and 47,XYY constitute the most common class of chromosome abnormality in human live births. Considerable
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Wnt Network: A Brief Review of Pathways and Multifunctional Components. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2020-01-01 Fereshte Abdolmaleki,Hossein Ahmadpour-Yazdi,Seyed Mohammad Gheibi Hayat,Nematollah Gheibi,Thomas P Johnston,Amirhossein Sahebkar
The Wnt signaling pathway appears to activate intracellular signaling transduction in embryonic development, cell migration, hematopoiesis, and several diseases. Wnt signaling is basically recognized as a canonical β-catenin-dependent signaling pathway. However, in recent years, generally three Wnt-mediated pathways have been investigated, which operate independently of β-catenin and include calci
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Association between the PAI-1 4G/5G Gene Polymorphism and the Risk of Systemic Lupus Erythematosus/Lupus Nephritis. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2019-01-01 Wei Li,Song Mao,Liangxia Wu,Wenjing Shi,Jianhua Zhang,Zhong Wang
Plasminogen activator inhibitor type 1 (PAI-1) correlates with the risk and progression of systemic lupus erythematosus (SLE). We aimed to assess the relationship between the PAI-1 4G/5G gene polymorphism and SLE/lupus nephritis risk. We identified the eligible studies regarding the association between the PAI-1 4G/5G gene polymorphism and the risk of SLE/lupus nephritis. The odds ratios (ORs) and
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The World after Ebola: An Overview of Ebola Complications, Vaccine Development, Lessons Learned, Financial Losses, and Disease Preparedness. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2019-01-01 Yasir Waheed,Shiza Malik,Maham Khan,Muzammil Hasan Najmi
The 2014-2016 Ebola outbreak in West Africa was the largest of its kind with 11,000 deaths and approximately 28,637 affected cases. The aim of the study was to analyze the global situation after the Ebola outbreak including Ebola complications, vaccine development, lessons learned, financial losses, and disease preparedness. We searched in PubMed, Google, and Google Scholar by using keywords Ebola
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Calcium-Sensing Receptor Arbitrates Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells via the G Protein-PLC-IP3 Pathway. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2019-01-01 Hui Zhang,Zhenyu Chang,Khalid Mehmood,Keli Yang,Zewen Liu,Zhengying Duan,Fangyan Yuan,Zuowu Jiao,Wei Liu,Ting Gao,Xiaoying Pei,Muhammad Ijaz,Muhammad Taslim Ghori,Yongxiang Tian,Rui Guo
Pulmonary arterial hypertension (PAH), also known as broilers ascites syndrome, is characterized by hypoxia, pulmonary artery pressure, and right heart failure. However, less information is available about the molecular mechanisms of PAH. We evaluated the mediation of calcium-sensing receptor by inducing hypoxia for the possible proliferation of pulmonary artery smooth muscle cells via the G protein
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Computational Modeling of Bone Cells and Their Biomechanical Behaviors in Responses to Mechanical Stimuli. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2019-01-01 Liping Wang,Jianghui Dong,Cory J Xian
Bone cells, including osteoblasts, osteoclasts, and osteocytes, have the ability to develop and maintain bone architecture. Although improved experimental testing approaches are increasing our understanding of the complex structures and functions of bone cells and bone, computational models, particularly finite element analyses, are being used to extend this knowledge and to develop a more theoretical
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Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients. Crit. Rev. Eukaryot. Gene Expr. (IF 2.156) Pub Date : 2019-01-01 Saima Sharif,Maha Maqsood,Shagufta Naz,Farkhanda Manzoor,Malik Shah Jahan,Tasnim Farasat
Type 2 diabetes mellitus (T2DM) is the most common metabolic and multifactorial disease in which both genetic and environmental factors are involved. In diabetes, the defects in the cellular metabolism result in higher levels of free radicals. These radicals react with other vital cellular molecules, which are responsible in diabetes side effects and known as diabetic retinopathy (DR), a disease of
更新日期:2019-11-01