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Amelioration of oxidative and inflammatory changes by Peganum harmala seeds in experimental arthritis Clin. Phytosci. Pub Date : 2021-01-22 Ashish Singhai; Umesh Kumar Patil
The present study was designed to investigate the therapeutic effects against oxidative stress and alleviative effects of Peganum harmala seeds (PH) in rats with Complete Freund’s Adjuvant (CFA) induced arthritis. The extract was evaluated for its phytoconstituents, antiarthritic and antioxidant properties. The action of chloroform (PHC) and ethanolic (PHE) extracts of PH was evaluated in adult Lewis
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Composition and biological assays of the leaf essential oil of Asparagus flagellaris (Kunth) Bak Clin. Phytosci. Pub Date : 2021-01-22 Oluwakayode O. Odeja; Michael Gabriel Ibok; Ejike O. Okpala
Asparagus flagellaris leaves are ethnomedicinally used to treat syphilis, gonorrhea and other sexually transmitted diseases (STDs), with no reports on the volatile constituents. This study was aimed to quantitatively and qualitatively characterise the composition of essential oil, evaluates the free radical scavenging and antimicrobial capacity of the essential oil. The essential oil was isolated by
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Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice Clin. Phytosci. Pub Date : 2021-01-20 Muhammad Torequl Islam; Thoufiqul Alam Riaz; Seyed Abdulmajid Ayatollahi; Javad Sharifi-Rad
Anxiety disorders are general and psychological problems that are also linked to symptoms of depression. This study aimed to investigate the anxiolytic-like effects of Urena lobata L. (MEUL) methanolic extract in different behavioral paradigms in Swiss albino mice. For this, after an oral acute toxicity study, adult male mice were treated with MEUL (250 and 500 mg/kg, p.o.) and/or diazepam (2 mg/kg
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Efficacy of an herbal preparation based on lovage, rosemary, and centaury on patients after extracorporal shockwave lithotripsy Clin. Phytosci. Pub Date : 2021-01-20 Volodymyr Frankovych Vitkovskyy
To study the effect of a herbal preparation containing a standardised BNO 1040 extract* (based on lovage root, rosemary leaves and aerial parts of centaury) on the extracorporeal shockwave lithotripsy (ESWL) results in patients with urolithiasis (UL). 150 patients with UL (aged 18–65 years) treated with ESWL method were divided into 2 equal groups. The main group (n = 75) received standard recommendations
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Overview on pharmacovigilance of nephrotoxic herbal medicines used worldwide Clin. Phytosci. Pub Date : 2021-01-19 Noufissa Touiti; Tarik Sqalli Houssaini; Sanae Achour
There is a growing use of herbal medicines worldwide. Especially in patients with chronic diseases such as kidney disease, when numerous studies have shown a generalized high prevalence [1,2,3,4]. However, there are concerns about herbal medicines and their ability to produce harmful effects. Examples from the literature have clearly shown the association between the use of herbs and kidney disease
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Characterization of pharmacological properties of methanolic seed and stem bark extracts of Ziziphus mauritiana (BAU Kul) using in-vitro and in-vivo animal (Swiss albino male mice) model Clin. Phytosci. Pub Date : 2021-01-16 Md. Khokon Miah Akanda; A. H. M. Nazmul Hasan
Ziziphus mauritiana belongs to family of Rhamnaceae, is an improved fast-growing variety of plum and seasonal fruit which is very popular and commonly known as “BAU Kul” in Bangladesh. This study was designed to evaluate the medicinal values of seed and stem bark extracts of Ziziphus mauritiana. Antioxidant, thrombolytic, membrane stabilizing, cytotoxic and antimicrobial activities were characterized
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Evaluation of anti-arthritic and anti-inflammatory activities of Martynia annua L. Ethanolic extract Clin. Phytosci. Pub Date : 2021-01-16 Suruj Kaushik; Parag Jain; Trilochan Satapathy; Prerna Purabiya; Amit Roy
Arthritis is a disorder of change in joint architecture and ligament degeneration. Rheumatoid arthritis is an autoimmune disorder in which body’s immune system targets own cells and degrade them. Martynia annua L. has been used in Indian traditional therapies for the treatment of epilepsy, many types of inflammations, respiratory infection, sore throat and wound. The objective of the present study
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Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice Clin. Phytosci. Pub Date : 2021-01-15 Valrielyn Saio; Donkupar Syiem; Ramesh Sharma; Careen Liza Pakyntein
In the pathogenesis of a variety of human diseases including diabetes mellitus, oxidative stress and subsequent oxidative damage to tissues have been involved [1]. Reactive oxygen species (ROS), especially mitochondrial ROS, play a significant causal role in the development and progression of diabetes and its complication [2, 3] such as retinopathy, neuropathy, nephropathy, and cardiovascular diseases
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Antiglycation potential of Indigoferin a, Indigoferin B and Indigoferin C natural products from Indigofera heterantha Brandis Clin. Phytosci. Pub Date : 2021-01-06 Ayesha Khan; Ajmal Khan; Manzoor Ahmad; Mumtaz Ali; Umar Farooq; Farhan Ahmad Khan; Syed Majid Bukhari
Diabetes is a long-lasting and serious disease that effect in worldwide individual lives, families, and societies. Hyperglycemia of diabetes mellitus produced Advance Glycation End Products that are associated with diabetic complications like neuropathy, nephropathy, retinopathy, and cardiovascular diseases. In this study, the natural products isolated from of Indigofera heterantha Brandis, Indigoferin
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Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs Clin. Phytosci. Pub Date : 2021-01-03 Earnest Oghenesuvwe Erhirhie; Chidozie Ikegbune; Anthony Ifeanyi Okeke; Chukwunonso Chukwudike Onwuzuligbo; Ngozi Ukamaka Madubuogwu; Uche Maryann Chukwudulue; Onyinye Blessing Okonkwo
Development of resistance by malaria parasites to conventional antimalarial drugs has rejuvenated the exploration of herbal medicine as alternatives. Also, the increasing rate of the use of herbal antimalarial remedies in combination with conventional antimalarial drugs (both synthetic and semi-synthetic) has inspired researchers to validate their herb-drug interaction effects. This review evaluated
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Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats Clin. Phytosci. Pub Date : 2021-01-03 Efosa Godwin Ewere; Ngozi Paulinus Okolie; Erhunmwunsee Dalton Avan; Patience Edet Umoh
Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative effects of the ethanol leaf (ELEIG) and stem bark extracts (ESEIG) of Irvingia gabonensis on sodium arsenite (SA)-induced lipid profile disturbances in Wistar rats were investigated. Fifty five
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Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies Clin. Phytosci. Pub Date : 2021-01-03 Emmanuel Sina Akintimehin; Kayode Olayele Karigidi; Tope Samuel Omogunwa; Foluso Olutope Adetuyi
Consumption of medicinal plants has diverse therapeutic benefits and could also have toxic effect. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. Powdered
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Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats Clin. Phytosci. Pub Date : 2021-01-02 Abdullah M. Tauheed; Mohammed Mamman; Abubakar Ahmed; Na’imatu A. Sani; Mohammed M. Suleiman; Mohammed H. Sulaiman; Emmanuel O. Balogun
Azadirachta indica, Khaya senegalensis, Anogeissus leiocarpus and Tamarindus indica are important ethnomedicinal plants used for health mitigation since the history of mankind. They are used discretionarily in folkloric medicine on the premise that they are natural products devoid of synthetic preservatives. However, nature endows plants with metabolites for warding off potential attacks from animals
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In vitro antidiabetic potentials, antioxidant activities and phytochemical profile of african black pepper (Piper guineense) Clin. Phytosci. Pub Date : 2020-12-14 L. A. Sulaimon; E. O. Anise; E. M. Obuotor; T. A. Samuel; A. I. Moshood; M. Olajide; T. Fatoke
Diabetes mellitus is a metabolic disorder of glucose metabolism and management of blood glucose level is the hallmark in the treatment of this disease. The present study investigated chemical composition, in vitro antioxidant and antidiabetic activity of different fractions of 80% methanol Piper guineense leaves extract. The crude methanolic extract of P. guineense was obtained following 80% methanol
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Cytotoxic metabolites from Thysanolaena maxima Roxb. available in Bangladesh Clin. Phytosci. Pub Date : 2020-12-11 Nazia Hoque; Md. Hossain Sohrab; Farhana Afroz; Satyajit Roy Rony; Suriya Sharmin; Fatema Moni; Choudhury Mahmood Hasan; Md. Sohel Rana
Thysanolaena maxima (Roxb.) Kuntze, a perennial grass plant, is usually distributed in hilly regions of the Indian Subcontinent. Different parts of T. maxima have been used as herbal medicine by traditional healers of this region. In this present study, T. maxima plant extract has been screened for examination of its secondary metabolite content with their probable cytotoxic activity. Secondary metabolites
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Investigation of the nutritional value and antioxidant activities of common Bangladeshi edible mushrooms Clin. Phytosci. Pub Date : 2020-12-11 Nazifa Sifat; Farhana Lovely; S. M. Neamul Kabir Zihad; Md. Golam Hossain; Jamil A. Shilpi; I. Darren Grice; Mohammad S. Mubarak; Shaikh Jamal Uddin
Mushrooms have been recognized both as medicine and nutritional food in many countries for thousands of years, owing to the presence of significant amounts of carbohydrates, proteins, lipids, fibers, and antioxidants. This study aims at evaluating the nutritional contents and antioxidant potentials of seven types of mushrooms cultivated in Bangladesh. Proximate composition analysis of the collected
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Lophira lanceolata protects testicular and spermatological damages induced by cisplatin in male Wistar rats Clin. Phytosci. Pub Date : 2020-12-08 Solomon Tsekohol Agu; Christian Okechukwu Ezihe; Paul Friday Itodo; Hyacinth Adakole Abu
Chemotherapy is associated with male infertility. Cisplatin (CP), an antineoplastic agent has been successfully used for the treatment of diverse kinds of malignancies, however, the use of this effective agent could induce oxidative stress injury, nephrotoxicity, hepatotoxicity, and testicular damage. Combined CP chemotherapy with plant extracts can diminish the toxicity and enhance the antitumor efficacy
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Phytochemical screening and antioxidant, analgesic, and anthelmintic effect of ethanolic extract of Merremia umbellate stems Clin. Phytosci. Pub Date : 2020-12-07 Mst Nazmun Nahar; Amit Kumar Acharzo; Md Sohanur Rahaman; Iffat Ara Zabeen; Shariful Haque; Md Amirul Islam
Merremia umbellata subsp. orientalis (Hallier f.), commonly known as Sapussunda in Bengali, is used in folk medicine for the treatment of different diseases such as helminthiasis, rheumatism, fever, wounds, burns, sores, management of pain due to cut etc. The present study was carried out to evaluate the antioxidant, analgesic and anthelmintic activities of ethanolic extract of stems of Merremia umbellate
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Evidence-based management of acute rhinosinusitis with herbal products Clin. Phytosci. Pub Date : 2020-12-07 Claus Bachert
The overuse of antibiotics for unjustified indications such as the management of acute uncomplicated rhinosinusitis has contributed to the emergence of antibiotic-resistant strains of bacteria and prompted the need for alternative treatments. This review assesses the quality of evidence for the management of acute rhinosinusitis with herbal products, with the goal of positioning them among other treatments
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A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity Clin. Phytosci. Pub Date : 2020-12-07 Shibam Karmakar; Somnath Paul; Nripendra Madhab Biswas; Jasmina Khanam; Sudip Kumar Kar; Hemanta Mukherjee; Sourav Poddar
Trend analysis, graphical representation, and summarization of pharmacological research trends were carried out to act as guidance for the future. The main objectives of the research are to find out the complete research trend on the national tree of India so far and to validate its traditional uses along with the pharmacological hepatoprotective activity of Ficus benghalensis L. by developing three
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In-Vitro antioxidant, anti-lipid peroxidative activities and In-Silico study of Terminalia chebula bioactive compounds Clin. Phytosci. Pub Date : 2020-12-05 Syed Mubashar Sabir; Syed Rizwan Abbas; Shabnam Shahida; Muhammad Faraz Khan
To evaluate the antioxidant activities and to identify the bioactive compounds in hot water extracts of Terminalia chebula fruit. The antioxidant activities were determined by DPPH assay, lipid peroxidation assay, iron chelation and total antioxidant assay. The phenolic composition was determined by HPLC-DAD. Human Rab8b Protein was used for the validation of compounds as anti-inflammation. String
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An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin Clin. Phytosci. Pub Date : 2020-12-04 Reshu Tiwari; Mohammed Haris Siddiqui; Tarique Mahmood; Alvina Farooqui; Paramdeep Bagga; Farogh Ahsan; Arshiya Shamim
Curcumin, quercetin and rutin are flavonoids having strong antioxidant potential, individually used in treatment of numerous ailments. The safety assessment of each of them is already established but no toxicological assessment has been done that would guarantee the safe use of these three flavonoids when used as a polyherbal combination (PHC). The aim of this study to evaluate the possible toxicological
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Correlative study of heavy metal content with biological importance of Solanum virginianum leaf extract Clin. Phytosci. Pub Date : 2020-11-26 Biswash Guragain; Khem Raj Pant; Saugat Bhattarai; Narendra Kumar Chaudhary
Rapid urbanization and industrialization have greatly impacted the inherent soil composition. Heavy metals disposed in the environment by anthropogenic activities toxicate flora and ultimately affect the phytochemical profile of medicinal plants. We report here such an investigation of the heavy metal concentrations in the leaf extract of Solanum virginianum (S. virginianum). This work has been extended
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Effects of Cnidium monnieri (L.) Cuss. fruit extract on sexual behaviors in male rats Clin. Phytosci. Pub Date : 2020-11-25 Thuy Duong Dau; Minh Ha Le; Tran Thi Giang Huong Nguyen; Thi Ngoc Mai Dang; Thi Nguyet Que Do; Quynh Trang Tran
Cnidium monnieri (L.) Cuss. has been used for a long time according to the traditional experiences and documentation in order to treat male sexual disorders. Osthole is one of the main bioactive components in Cnidium monnieri (L.) Cuss. In this study, we aimed to evaluate the effect of Cnidium monnieri (L.) Cuss. fruit extract of which osthole content was 35% (determined by HPLC method) on sexual behaviors
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Exploration of the role of a lithophytic fern, Pteris vittata L. in wound tissue regeneration and remodelling of genes in hyperglycaemic rat model Clin. Phytosci. Pub Date : 2020-11-23 Tania S. Paul; Biswadeep B. Das; Yogesh P. Talekar; Suchitra Banerjee
In hyperglycemic conditions like diabetes, impaired wound healing occurs due to endothelial damage, dysfunction of leukocyte, decreased phagocytosis and secondary infection which may lead to amputation and debility. Ethnomedicinally, Pteris vittata L. (PV) is used for wound healing. This fern is arsenic hyper-accumulator but its therapeutic aspect is still unexplored. Hence, the present study was put
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Evaluation of in vivo wound healing activity of Moroccan Citrus reticulata peel extract Clin. Phytosci. Pub Date : 2020-11-23 Sanae Dahmani; Rachida Chabir; Faouzi Errachidi; Wiam Berrada; Hafsa Lansari; Meryem Benidir; Lahsen El Ghadraoui; Abdellatif Bour
Citrus reticulata is one of the most cultivated fruit with great benefits for humans in the world. Citrus reticulata peel has several biological activities within them hypoglycemic, hepatoprotective, antimicrobial and antioxidant. The present study emphasizes on the in vivo wound healing and in vitro antimicrobial and antioxidant activities of Citrus reticulata peel extract. Forty albino mice (23–29 g)
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Wound healing potentials of herbal ointment containing Calendula officinalis Linn. on the alteration of immunological markers and biochemical parameters in excision wounded animals Clin. Phytosci. Pub Date : 2020-11-23 Shobana Gunasekaran; Agnel Arul John Nayagam; Rameshkannan Natarajan
The present study was designed to investigate the in vivo wound healing activity of herbal ointment prepared from Calendula officinalis Linn. on excision wounded rats. The excision wound model was employed for wound healing activity in albino rats. Healthy albino rats (150–200 g) of either sex were taken for excision wound model. Animals were divided into five groups of six animals in each. Group I
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Evaluation of Andira inermis stem bark extract for hypoglycaemic and antioxidant effects’ Clin. Phytosci. Pub Date : 2020-11-13 Maxwell Osaronowen Egua; Florence Chimezie Nwinyi; Ode Julius Okwoche; Onakpa Micheal Monday; Akande Motunrayo Ganiyat; Onoja Samuel Okwudili; Mikail Hudu Garba; Akumka David Dezi; Adamu Mohammed
The aqueous methanolic extract of Andira inermis(A. inermis) stem bark was screened for phytochemical constituents, antioxidant activity, acute oral toxicity, and preliminary prophylactic normoglycaemic test and effect on Oral Glucose Tolerance in albino rats. Andira inermis was double macerated and extracted with 80% methanol. Phytochemical analysis and acute toxicity were performed using standard
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Identification of bioactive compounds by GC-MS and α-amylase and α-glucosidase inhibitory activity of Rauvolfia tetraphylla L. and Oroxylum indicum (L.) Kurz: an in vitro and in silico approach Clin. Phytosci. Pub Date : 2020-11-12 Ananta Swargiary; Manita Daimari
The practice of ethnomedicine remains to be the primary source of healthcare in many parts of the world, especially among the tribal communities. However, there is a lack of scientific outlook and investigation to authenticate and validate their medicinal values. The present study investigated the trace and heavy metal content, bioactive compounds, α-amylase, and α-glucosidase inhibitory activity of
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Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance Clin. Phytosci. Pub Date : 2020-11-11 Reyhane Javanshir; Moones Honarmand; Mehran Hosseini; Mina Hemmati
Nowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated. Formation of AuNPs was confirmed by UV-vis, HR-TEM and XRD. Different doses of jujube gold nanoparticles (0.5 and 1 mg/kg) were used to treat streptozotocin-induced
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The in vivo toxicity evaluation of leaf and root methanolic extracts of Tephrosia vogelii Hook.f using animal model Clin. Phytosci. Pub Date : 2020-11-10 Stephano Hanolo Mlozi; Juma A. Mmongoyo; Musa Chacha
Traditionally, herbal medicines are commonly used to cure several diseases since immemorial of human life. Nevertheless, the safety of some traditionally used medicinal plants is uncertain. Since Tephrosia vogelii Hook.f is a traditionally used medicinal plant, the effects of its extracts were evaluated on lethality (LD50) and sub-acute toxicity in this study. Phytochemistry screening and an in vivo
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Phytochemical and pharmacological activities of methanol extract of Artemisia vulgaris L. leaves Clin. Phytosci. Pub Date : 2020-11-09 Nurpen Meitei Thangjam; Jasmina Taijong; Awadhesh Kumar
Artemisia vulgaris commonly known as “mugwort” is a very important medicinal plant which is used widely for the treatment of various ailments traditionally. The present studies aimed to conduct preliminary phytochemical screening and evaluate antioxidants and analgesic activities of leaves extract. Phytochemical screening showed the presence of saponins, glycosides, flavanoids, protein, triterpenoids
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Protective effects of peel extracts of Irvingia wombolu on metabolic disorders in streptozotocin-induced diabetic rats Clin. Phytosci. Pub Date : 2020-11-09 Rosane Soh Matsinkou; Valere Aime Soh Oumbe; Judith Laure Ngondi; Julius Enyong Oben
Diabetes is widely recognized as associated with several structural and functional liver, kidney, and heart abnormalities. Therefore, the present study was conducted to evaluate the protective effect of peel extracts of Irvingia wombolu against diabetes complications. Diabetes was induced by intravenous administration of streptozotocin (STZ) (50 mg/kg) through the right jugular vein on rats and animals
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The phytochemical and pharmacological screening of three crude extracts of Desmodium canum (strong back) Clin. Phytosci. Pub Date : 2020-11-09 Ruby Lisa Alexander-Lindo; Roy Barrington Reynolds Porter; Chuckwuemeka Rapheal Nwokocha; Kemmoy Godfrey Lattibeaudiere
Desmodium canum (Strong Back) is deemed a versatile traditional medicine, where it is used to treat diabetes, hypertension, asthma and erectile dysfunction. To identify the various phytochemicals present within extracts of D. canum, their antioxidant capabilities and their effects on blood glucose levels, haemodynamic parameters and testosterone levels in healthy Sprague-Dawley (S-D) rats. Crude extracts
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Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats Clin. Phytosci. Pub Date : 2020-11-07 Kumaraswamy Athesh; Rangaraju Sivasubramanian; Gnanasekaran Jothi; Pemiah Brindha
Obesity, reached epidemic proportions globally is often associated with life threatening comorbidities. The unavailability of safe and effective long term medications for obesity in modern pharmacotherapy forces the scientific community to explore the potential of Ayurvedic traditional healers as they are considered safe and effective. To explore the anti-obesity potential of aqueous extract of aerial
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Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression Clin. Phytosci. Pub Date : 2020-10-15 Syed Abdul Kuddus; Mazharul Islam Bhuiyan; Nusrat Subhan; Md Hasanuzzaman Shohag; Aura Rahman; Muhammad Maqsud Hossain; Md Ashraful Alam; Ferdous Khan
Different parts of the medicinal plant Tamarindus indica L. are full of phytochemicals that are able to reduce elevated blood pressure, blood sugar and lipids. These pharmacological effects are due to the presence of antioxidant type compounds in those parts of the plant. This study was aimed to explore the molecular mechanism of anti-obesity effects of ethanolic extract of T. indica L. leaves (TILE)
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Cardioprotective effect of garlic extract in isoproterenol-induced myocardial infarction in a rat model: assessment of pro-apoptotic caspase-3 gene expression Clin. Phytosci. Pub Date : 2020-09-18 Dipa Islam; Monisha Banerjee Shanta; Samina Akhter; Chadni Lyzu; Mahmuda Hakim; Md. Rezuanul Islam; Liton Chandra Mohanta; Evena Parvin Lipy; Dipankar Chandra Roy
Myocardial Infarction (MI), also known as heart attack, is one of the most common cardiovascular diseases. Although certain drugs or mechanical means are used, day by day natural products such as herbs and spices based MI treatment is getting much popularity over the drugs or mechanical means for their pharmacological effects and have low or no side effects. This study was designed to assess the cardio-protective
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An in vitro screening potential traditional medicinal plants for nephrolithiasis Clin. Phytosci. Pub Date : 2020-09-12 Majid Shirani; Davood Arjaki; Soleiman Kheiri; Elham Bijad; Sareh Mohammadi; Zahra Lorigooini
Today, the attention of researchers has been drawn to the use of medicinal plant for the treatment of kidney stones. The aim of this study was to investigate the effect of five plants used in traditional medicine on the dissolution of calcium oxalate and calcium phosphate stones. Then, the ability of more effective plants to dissolve stones collected from patients after Percutaneous Nephrolithotripsy
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Effect of hydro-methanol stem bark extract of Burkea africana on erythrocyte osmotic fragility and haematological parameters in acetaminophen-poisoned rats Clin. Phytosci. Pub Date : 2020-09-07 Terhemen Festus Swem; Patrick Emeka Aba; Samuel Chukwuneke Udem
Burkea africana is a widely used medicinal plant in folkloric medicine in many developing countries of the world. It is useful in the treatment of various ailments including hepatitis, jaundice, diarrhea, stomach aches, abscesses, oedema, epilepsy, bloody diarrhea, gonorrhea, syphilis, toothaches and poisoning. Nevertheless, there are little or no scientific evidence to substantiate this medicinal
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Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats Clin. Phytosci. Pub Date : 2020-09-06 Kazeem Akinyinka Akinwumi; Afusat Jagun Jubril; Oreoluwa Oluwafunke Olaniyan; Yusuf Yusuf Umar
Nickel exposure causes hepato-renal toxicity via oxidative stress. Medicinal plants with antioxidants properties are being explored as treatment options. In this study, the effect of ethanol extract of Nigella sativa (ENS) on nickel chloride (NiCl2)-induced hepato-renal damage was evaluated by monitoring biochemical and oxidative stress markers. Additionally, the antioxidant capacity and phytochemical
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Bridelia ferruginea Benth leaves attenuates diabetes nephropathy in STZ-induced rats via targeting NGAL/KIM-1/cystatin c gene Clin. Phytosci. Pub Date : 2020-09-04 Damilola Alex Omoboyowa; Kayode Olayele Karigidi; Temitope Cosmas Aribigbola
Renal failure is among the main complications of diabetes disorders and free radical from hyperglycemia is the major cause of this nephrotic complication. This study investigated the therapeutic effects of Bridelia ferruginea Benth on nephrotic damage in streptozotocin (STZ) induced diabetic rats. Diabetes mellitus was induced by injection of 50 mg/kg b. w. of STZ (intraperitoneal) in rats fasted overnight
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Correction to: Promising anitidiabetic potential of Cuscuta reflexa leaves methanol extract in alloxaninduced diabetic rats Clin. Phytosci. Pub Date : 2020-09-02 Ronia Mostofa; Rayhana Begum; Hongbin Wang; Mst. Marium Begum; Rubaba Karim; Taslima Begum; Nur Alam Siddiquee; Rebeka Sultana; Sonia Sultana; A. K. Lutful Kabir; Sumaiya Alam; Tasnova Tasnim Nova
An amendment to this paper has been published and can be accessed via the original article.
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Triterpene saponins from Barringtonia acutangula (L.) Gaertn as a potent inhibitor of 11β-HSD1 for type 2 diabetes mellitus, obesity, and metabolic syndrome Clin. Phytosci. Pub Date : 2020-09-02 Vishal Shivalingappa Patil; Nayeem A. Khatib
Barringtonia acutangula (L.) Gaertn, Garcinia indica (Thouars) Choisy, and Feronia limonia (L.) Swingle is widely utilized in traditional folk medicine against diabetes, obesity, and metabolic syndrome but lacks the evidence of compound-protein interaction for the treatment. Phytocompounds were retrieved from herbs databases and public repositories. Probable protein targets were predicted using BindingDB
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Stem extract of Albizia richardiana exhibits potent antioxidant, cytotoxic, antimicrobial, anti-inflammatory and thrombolytic effects through in vitro approach Clin. Phytosci. Pub Date : 2020-09-01 Mohammad Nazmul Islam; Homyra Tasnim; Laiba Arshad; Md. Areeful Haque; Syed Mohammed Tareq; A. T. M. Mostafa Kamal; Md. Masudur Rahman; A S. M. Ali Reza; Kazi Ashfak Ahmed Chowdhury; Abu Montakim Tareq
Albizia richardiana belongs Fabaceae family which different parts like fruits, flowers, barks, and roots are used medicinally. The study reports the in vitro anti-inflammatory, thrombolytic, cytotoxicity and antimicrobial activity of methanolic extract of A. richardiana stem and its different fractions. The methanolic extract of A. richardiana stem (MEAR) extracted with n-hexane (HXFAR), carbon tetrachloride
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Membrane stabilization as a mechanism of the anti-inflammatory activity of ethanolic root extract of Choi (Piper chaba) Clin. Phytosci. Pub Date : 2020-08-27 Samina Yesmin; Arkajyoti Paul; Tarannum Naz; A. B. M. Atiqur Rahman; Sarkar Farhana Akhter; Mir Imam Ibne Wahed; Talha Bin Emran; Shafayet Ahmed Siddiqui
This experiment is conducted to evaluate the anti-inflammatory effect of Piper chaba roots. The in-vitro anti-inflammatory activity of Piper chaba was carried out by human red blood cell (HRBC) membrane stabilization method which includes heat-induced hemolysis and hypo tonicity- induced hemolysis and also by another method of egg albumin denaturation assay. Anti-inflammatory activity study of crude
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Antidiabetic effect of Wedelia chinensis leaf extract in alloxan induced Swiss albino diabetic mice Clin. Phytosci. Pub Date : 2020-08-14 Md. Wasim Bari; Md. Monirul Islam; Mahbuba Khatun; Mst Julia Sultana; Rabbi Ahmed; Ariful Islam; Md. Ismail Hossain; Md. Matiar Rahman; Mohammad Amirul Islam
Wedelia chinensis (W. chinensis) is a beneficial medicinal herb used in folk medicine to treat many chronic diseases. The present study is aimed to evaluate the antidiabetic property of methanolic extract of W. chinensis leaf (MEWL) in alloxan induced Swiss albino diabetic mice. Methanol was used as a solvent to obtain W. chinensis leaf extract. In vitro antidiabetic property of MEWL was revealed by
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Effects of aqueous extract of fruit pulp of Adansonia digitata L. on the oxidative stress profile against Trypanosoma brucei brucei infection in albino rats Clin. Phytosci. Pub Date : 2020-08-14 Oluyomi Olajumoke Ogunleye; Isa Danladi Jatau; Audu Joseph Natala; Shola David Ola-Fadunsin
Chemotherapy is the most widely used means of controlling trypanosomosis, however, effectiveness of the drugs available is limited by a number of factors. This study investigates the oxidative stress profile of aqueous extract of the fruit pulp of Adansonia digitata on some organs in rats infected with Trypanosoma brucei brucei. Thirty-five male albino rats were divided into 7 groups of 5 rats each
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Characterization of anti-plasmodial, analgesic and anti-inflammatory fraction of Maytenus senegalensis (lam.) Exell leaf extract in mice Clin. Phytosci. Pub Date : 2020-08-14 Ali A. Jigam; Rachael Musa; Abdulkadir Abdullahi; Bashir Lawal
The treatment inadequacy and toxicity associated with conventional anti-malarial, anti-inflammatory and analgesic drugs has called for the search of alternatives from medicinal plants, particularly, their phytochemicals with inherent pharmacological properties. In the present study, purified fraction of M. senegalensis leaf was evaluated for antimalarial, anti-inflammatory and analgesic properties
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Anti-diabetic effects of pomegranate extracts in long-term high fructose-fat fed rats Clin. Phytosci. Pub Date : 2020-08-13 Zahra Amri; Mohamed Raâfet Ben Khedher; Mohamed Sghaier Zaibi; Wafa Kharroubi; Mouna Turki; Fatma Ayadi; Mohamed Hammami
A high-sugar or/and high-fat diets is a major risk factors for obesity. However, increased fruit and vegetable intake has been recently linked to obesity prevention. The aim of the present study was to investigate the preventive effects of pomegranate leaves (PL), juice (PJ) and peel (PP) extracts, on insulin resistance and oxidative stress in high fat and high fructose diet-induced obese rats. Obesity
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Ascorbic acid interaction with phytol: a modulatory effects on the anti-pyretic activity of paracetamol in Swiss albino mice Clin. Phytosci. Pub Date : 2020-08-12 Md. Mizanur Rahaman; S. M. Hafiz Hassan; Miquel Martorell; Javad Sharifi-Rad; Muhammad Torequl Islam
Antioxidants have protective capacity, and can be used combinedly with other substances. Both, ascorbic acid (AA) and phytol (PHY) have many important biological activities, including antioxidant, anti-inflammatory, and organ protective activity. Recently, PHY has been found to exert an anti-pyretic effect in a mouse model. This study aims to evaluate the combined effects of AA and/or PHY with paracetamol
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Endangered Saudi Arabian plants having ethnobotanical evidence as antidotes for scorpion envenoming Clin. Phytosci. Pub Date : 2020-07-29 Abdulrahman Khazim Al-Asmari; Rajamohamed Abbasmanthiri; Nasreddien Mohammed Abdo Osman; Byan Abdulrahman Al-Asmari
Scorpion sting envenoming in Saudi Arabia posed major public health problems. Conventional treatment with antivenom with its limitations and hazards called for the use of support remediation like prazosin therapy and phytotherapy as alternative solutions in systematic medicine and a trend of use in medicinal plants. The present study is aiming to procure the medicinal plants that exhibit antidotes
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Medicinal plants utilized for hepatic disorders in Ethiopian traditional medical practices: a review Clin. Phytosci. Pub Date : 2020-07-29 Abrham Belachew Muluye; Muluken Wubetu Ayicheh
Ethiopia is among the top floral biodiversity rich countries in the world. More than 7000 species of plants, 15% of they are endemic, are reported in the country. Accessibility, cultural enrichment, and cheapness make 80% of the Ethiopian people used indigenous plants for various health ailments and diseases in their traditional medical practices. Therefore, the current review examined the use patterns
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Ameliorative effect of Psidium guajava (l.) leaf aqueous extract on aluminium nitrate-induced liver damage in female Wistar rats Clin. Phytosci. Pub Date : 2020-07-29 Aanuoluwapo Adeyimika Afolabi; Ebenezer Adeola Ashamu; Olufemi Idowu Oluranti
Aluminium nitrate and other aluminium-containing compounds have been demonstrated to cause several health challenges. Psidium guajava L) is a well known cultivated tree with hepatoprotective nature and radical scavenging ability. Twenty-five (25) female Wistar rats with average weight of 195 g were grouped into five groups (n = 5), with their weights measured and recorded weekly throughout the period
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Self-emulsifying formulation of Spinacia oleracea reduces the dose and escalates bioavailability of bioactive compounds to accelerate fracture repair in rats Clin. Phytosci. Pub Date : 2020-07-24 Ritu Trivedi; Sulekha Adhikary; Priyanka Kothari; Naseer Ahmad; Naresh Mittapelly; Gitu Pandey; Mahendra Shukla; Sudhir Kumar; Kapil Dev; Dharmendra Choudhary; Rakesh Maurya; Jawahar Lal; Prabhat Ranjan Mishra
Spinach (Spinacia oleracea) is a rich source of flavonoids and therefore widely used therapeutically as an antioxidant agent in traditional medicine. The present study was undertaken to study the bone regenerating property of dried Spinacia oleracea extract (DSE) and self-emulsifying formulation of the extract (FDSE) on drill-hole model of fracture repair in rats. 0.8 mm hole was drilled in the diaphyseal region
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Inhibitory effects of Mezoneuron benthamianum root extracts on oral cariogenic microorganisms and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging radical Clin. Phytosci. Pub Date : 2020-07-20 Paul M. Osamudiamen; Bolaji B. Oluremi; Fisayo T. Osamudiamen; Olapeju O. Aiyelaagbe
Chewing sticks are commonly used as oral hygiene tool in Africa and reactive oxygen species have been linked to the cause of degenerative diseases because of their ability to induce oxidative damage to biological molecules. Plants have been a long source of dietary antioxidants as most plants have been found to exhibit excellent antioxidant potentials. Mezoneuron benthamianum is a plant that is used
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Food-drug interaction and pharmacokinetic study between fruit extract of Capsicum frutescens L. and glimepiride in diabetic rats Clin. Phytosci. Pub Date : 2020-07-12 Mettupalayam Annadurai Raja; Prasenjit Mondal; Kola Venu; Manish Kumar Thimmaraju; Poudala Kiran
The present study was designed to explore the food-drug and pharmacokinetic interaction between C.frutescens, a culinary herb on hypoglycemic activity of glimepiride, a sulfonyl urea derivative used in the treatment of type-2 diabetes) in diabetic rats in combination of each as single doses for one day. Further it is also aimed to study the effect of AQEFCF on antidiabetic effect of glimepiride by
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Antioxidant and in vivo hepatoprotective effects of Gardenia gummifera L.f. fruit methanol extract Clin. Phytosci. Pub Date : 2020-07-12 N. M. Vinaykumar; Riaz Mahmood; V. Krishna; B. Ravishankara; Sudhesh L. Shastri
Gardenia gummifera L.f. (Family: Rubeacea) is used in indigenous system of medicine to cure many diseases. To authenticate the traditional medicinal claim investigation has been under taken to evaluate the antioxidant and hepatoprotective activities of Gardenia gummifera L.f. fruit methanol extract (GFME). GFME was evaluated using various antioxidant assays, including DPPH and Nitric oxide radical
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Quantitative phytochemical analysis and antimicrobial activities of fresh and dry ethanol extracts of Citrus sinensis (L.) Osbeck (sweet Orange) peels Clin. Phytosci. Pub Date : 2020-07-09 Ehigbai I. Oikeh; Faith E. Oviasogie; Ehimwenma S. Omoregie
Citrus sinensis is one of the most abundant citrus species consumed. Orange peels are a waste by-product of the fruit and may potentially contain useful phytonutrients with biological relevance. Fresh and dry peels of sweet orange were subjected to Soxhlet extraction and then concentrated using a rotary evaporator. Total phenolic, flavonoid and tannin content were determined using standard methods
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Phyto-therapeutic potential of stem bark of the wonder tree, Prosopis cineraria (L.) Druce in LPS-induced mouse model: An Anti-Inflammatory Study Clin. Phytosci. Pub Date : 2020-07-09 Veena Sharma; Preeti Sharma
Therapeutic potential of Prosopis cineraria has been extensively explored by many eminent researchers against various serious diseases but its activity against Lipopolysaccharide (endotoxin) is obscure. Therefore, present experimental investigation was conducted to unravel and analyze the anti-inflammatory potential of hydro-ethanol extract of Prosopis cineraria against LPS-induced inflammation in
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Quercus infectoria fruit hulls and galls and female genital disorders Clin. Phytosci. Pub Date : 2020-07-07 Mohaddese Mahboubi
Quercus infectoria (Fagaceae family) is traditionally used for treatment of vaginal discharge, prolapse, laxity, and many other female genital disorders. Two important parts of plant including oak fruit hulls (Jaft-E-Baloot) and oak galls (Mazo) are recommended to use for female genital disorders, although, they have many other medicinal applications on skin, urinary and respiratory tract. Tannins
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