Different parts of the medicinal plant Tamarindus indica L. are full of phytochemicals that are able to reduce elevated blood pressure, blood sugar and lipids. These pharmacological effects are due to the presence of antioxidant type compounds in those parts of the plant. This study was aimed to explore the molecular mechanism of anti-obesity effects of ethanolic extract of T. indica L. leaves (TILE)

Myocardial Infarction (MI), also known as heart attack, is one of the most common cardiovascular diseases. Although certain drugs or mechanical means are used, day by day natural products such as herbs and spices based MI treatment is getting much popularity over the drugs or mechanical means for their pharmacological effects and have low or no side effects. This study was designed to assess the cardio-protective

Today, the attention of researchers has been drawn to the use of medicinal plant for the treatment of kidney stones. The aim of this study was to investigate the effect of five plants used in traditional medicine on the dissolution of calcium oxalate and calcium phosphate stones. Then, the ability of more effective plants to dissolve stones collected from patients after Percutaneous Nephrolithotripsy

Burkea africana is a widely used medicinal plant in folkloric medicine in many developing countries of the world. It is useful in the treatment of various ailments including hepatitis, jaundice, diarrhea, stomach aches, abscesses, oedema, epilepsy, bloody diarrhea, gonorrhea, syphilis, toothaches and poisoning. Nevertheless, there are little or no scientific evidence to substantiate this medicinal

Nickel exposure causes hepato-renal toxicity via oxidative stress. Medicinal plants with antioxidants properties are being explored as treatment options. In this study, the effect of ethanol extract of Nigella sativa (ENS) on nickel chloride (NiCl2)-induced hepato-renal damage was evaluated by monitoring biochemical and oxidative stress markers. Additionally, the antioxidant capacity and phytochemical

Renal failure is among the main complications of diabetes disorders and free radical from hyperglycemia is the major cause of this nephrotic complication. This study investigated the therapeutic effects of Bridelia ferruginea Benth on nephrotic damage in streptozotocin (STZ) induced diabetic rats. Diabetes mellitus was induced by injection of 50 mg/kg b. w. of STZ (intraperitoneal) in rats fasted overnight

An amendment to this paper has been published and can be accessed via the original article.

Barringtonia acutangula (L.) Gaertn, Garcinia indica (Thouars) Choisy, and Feronia limonia (L.) Swingle is widely utilized in traditional folk medicine against diabetes, obesity, and metabolic syndrome but lacks the evidence of compound-protein interaction for the treatment. Phytocompounds were retrieved from herbs databases and public repositories. Probable protein targets were predicted using BindingDB

Albizia richardiana belongs Fabaceae family which different parts like fruits, flowers, barks, and roots are used medicinally. The study reports the in vitro anti-inflammatory, thrombolytic, cytotoxicity and antimicrobial activity of methanolic extract of A. richardiana stem and its different fractions. The methanolic extract of A. richardiana stem (MEAR) extracted with n-hexane (HXFAR), carbon tetrachloride

This experiment is conducted to evaluate the anti-inflammatory effect of Piper chaba roots. The in-vitro anti-inflammatory activity of Piper chaba was carried out by human red blood cell (HRBC) membrane stabilization method which includes heat-induced hemolysis and hypo tonicity- induced hemolysis and also by another method of egg albumin denaturation assay. Anti-inflammatory activity study of crude

Wedelia chinensis (W. chinensis) is a beneficial medicinal herb used in folk medicine to treat many chronic diseases. The present study is aimed to evaluate the antidiabetic property of methanolic extract of W. chinensis leaf (MEWL) in alloxan induced Swiss albino diabetic mice. Methanol was used as a solvent to obtain W. chinensis leaf extract. In vitro antidiabetic property of MEWL was revealed by

Chemotherapy is the most widely used means of controlling trypanosomosis, however, effectiveness of the drugs available is limited by a number of factors. This study investigates the oxidative stress profile of aqueous extract of the fruit pulp of Adansonia digitata on some organs in rats infected with Trypanosoma brucei brucei. Thirty-five male albino rats were divided into 7 groups of 5 rats each

The treatment inadequacy and toxicity associated with conventional anti-malarial, anti-inflammatory and analgesic drugs has called for the search of alternatives from medicinal plants, particularly, their phytochemicals with inherent pharmacological properties. In the present study, purified fraction of M. senegalensis leaf was evaluated for antimalarial, anti-inflammatory and analgesic properties

A high-sugar or/and high-fat diets is a major risk factors for obesity. However, increased fruit and vegetable intake has been recently linked to obesity prevention. The aim of the present study was to investigate the preventive effects of pomegranate leaves (PL), juice (PJ) and peel (PP) extracts, on insulin resistance and oxidative stress in high fat and high fructose diet-induced obese rats. Obesity

Antioxidants have protective capacity, and can be used combinedly with other substances. Both, ascorbic acid (AA) and phytol (PHY) have many important biological activities, including antioxidant, anti-inflammatory, and organ protective activity. Recently, PHY has been found to exert an anti-pyretic effect in a mouse model. This study aims to evaluate the combined effects of AA and/or PHY with paracetamol

Scorpion sting envenoming in Saudi Arabia posed major public health problems. Conventional treatment with antivenom with its limitations and hazards called for the use of support remediation like prazosin therapy and phytotherapy as alternative solutions in systematic medicine and a trend of use in medicinal plants. The present study is aiming to procure the medicinal plants that exhibit antidotes

Ethiopia is among the top floral biodiversity rich countries in the world. More than 7000 species of plants, 15% of they are endemic, are reported in the country. Accessibility, cultural enrichment, and cheapness make 80% of the Ethiopian people used indigenous plants for various health ailments and diseases in their traditional medical practices. Therefore, the current review examined the use patterns

Aluminium nitrate and other aluminium-containing compounds have been demonstrated to cause several health challenges. Psidium guajava L) is a well known cultivated tree with hepatoprotective nature and radical scavenging ability. Twenty-five (25) female Wistar rats with average weight of 195 g were grouped into five groups (n = 5), with their weights measured and recorded weekly throughout the period

Spinach (Spinacia oleracea) is a rich source of flavonoids and therefore widely used therapeutically as an antioxidant agent in traditional medicine. The present study was undertaken to study the bone regenerating property of dried Spinacia oleracea extract (DSE) and self-emulsifying formulation of the extract (FDSE) on drill-hole model of fracture repair in rats. 0.8 mm hole was drilled in the diaphyseal region

Chewing sticks are commonly used as oral hygiene tool in Africa and reactive oxygen species have been linked to the cause of degenerative diseases because of their ability to induce oxidative damage to biological molecules. Plants have been a long source of dietary antioxidants as most plants have been found to exhibit excellent antioxidant potentials. Mezoneuron benthamianum is a plant that is used

The present study was designed to explore the food-drug and pharmacokinetic interaction between C.frutescens, a culinary herb on hypoglycemic activity of glimepiride, a sulfonyl urea derivative used in the treatment of type-2 diabetes) in diabetic rats in combination of each as single doses for one day. Further it is also aimed to study the effect of AQEFCF on antidiabetic effect of glimepiride by

Gardenia gummifera L.f. (Family: Rubeacea) is used in indigenous system of medicine to cure many diseases. To authenticate the traditional medicinal claim investigation has been under taken to evaluate the antioxidant and hepatoprotective activities of Gardenia gummifera L.f. fruit methanol extract (GFME). GFME was evaluated using various antioxidant assays, including DPPH and Nitric oxide radical

Citrus sinensis is one of the most abundant citrus species consumed. Orange peels are a waste by-product of the fruit and may potentially contain useful phytonutrients with biological relevance. Fresh and dry peels of sweet orange were subjected to Soxhlet extraction and then concentrated using a rotary evaporator. Total phenolic, flavonoid and tannin content were determined using standard methods

Therapeutic potential of Prosopis cineraria has been extensively explored by many eminent researchers against various serious diseases but its activity against Lipopolysaccharide (endotoxin) is obscure. Therefore, present experimental investigation was conducted to unravel and analyze the anti-inflammatory potential of hydro-ethanol extract of Prosopis cineraria against LPS-induced inflammation in

Quercus infectoria (Fagaceae family) is traditionally used for treatment of vaginal discharge, prolapse, laxity, and many other female genital disorders. Two important parts of plant including oak fruit hulls (Jaft-E-Baloot) and oak galls (Mazo) are recommended to use for female genital disorders, although, they have many other medicinal applications on skin, urinary and respiratory tract. Tannins

An amendment to this paper has been published and can be accessed via the original article.

In the present investigation an attempt was made to evaluate the potential of agnucastoside C (ACC), isolated from the leaves of Moringa oleifera in ameliorating thyrotoxicosis, hepatic lipid peroxidation (LPO) and hyperglycemia in female mice. L-thyroxine (L-T4) at 0.5 mg/kg/d was administered through intra-peritoneal route for 15 consecutive days to induce thyrotoxicosis and then the effects of three

Spathodea campanulata P. Beauv. (Bignoniaceae) is a very common plant in Bangladesh which is locally called “Rudrapalash”. In Nigeria leaves extract of S. campanulata has a reputation of being used as an anticonvulsant. In this connection, the aim of this study was to investigate other neuropharmacological effects like sedative and anxiolytic activities of methanol extract of S. campanulata (MESC)

Herbal medicines are used for the treatment of many infectious diseases throughout the history of mankind. The increasing antibiotic resistance exhibited by microorganisms has led to the phytochemical screening of medicinal plants for antimicrobial activity. Many infections can be treated by phytochemicals possessing potent antibacterial efficiency. The pharmacological activities of any plant is because

An amendment to this paper has been published and can be accessed via the original article.

Overdose of paracetamol affects liver cells leading to cell death. This is done through hepatic necrosis, which is characterized by a rupture of the plasma membrane. A variety of investigations has been conducted using herbal extracts to assess liver toxicity induced by paracetamol. Here we examined herbal plant species, Acridocarpus orientalis (A. orientalis), ethanolic extract to study its potential

An amendment to this paper has been published and can be accessed via the original article.

The present study investigated the anti-Trypanosoma brucei brucei activity of methanolic extract of Senna occidentalis roots, leaves, stem bark, and seed in vitro and bioactive components of the most active plant part. Trypanosoma brucei brucei was identified by PCR, cultured in Dulbecco’s Modified Eagle Medium (DMEM) and incubated at 37 °C and 5% CO2. Subsequently, the cultured T. brucei brucei were

In an attempt to explore the scientific basis for the pharmacological benefits the antioxidant and antimicrobial activities of Ipomoea mauritiana whole plant methanol extract were assessed. The total phenolic and flavonoid content were determined using standard method while antioxidant activity was determined by DPPH free radical scavenging activity method. The antimicrobial activity was evaluated

α-Amylase catalyses the hydrolysis of starch and ultimately producing glucose. Controlling the catalytic activity of this enzyme reduces glucose production in the postprandial stage, which could be a therapeutic benefit for people with diabetes. This study was conducted to evaluate α-amylase inhibition for utilizing the crude extracts of some medicinal plants traditionally used in Nepal for the treatment

Various parts i.e., stem bark, leaf, root and flower of Neolamarckia cadamba (Roxb.) Bosser has been extensively used by traditional practitioners to treat all types of diabetes. Our present study investigated the antidiabetic property of the extract from its flower and evaluated its traditional use for diabetes. Phenolic contents were found to be higher in the methanol soluble fraction (MESF) (228

Antigonon leptopus is a medicinal plant its leaves has not been reported for protective effects against cadmium induced hepatorenal toxicity. Cadmium (Cd) is a non-essential toxic metal used in industrial process, causes severe risk to human health with high levels. It is accumulated primarily in liver and kidney. Male Wistar albino rats (200-250 g) were divided into 6 groups (n = 6) and had free access

The stem bark aqueous alcohol extract of Poincianella pluviosa (PPSB extract) is rich in bioactives including gallic acid, gallic acid methyl ester, pyrogallol, ellagic acid, corilagin, 1,4,6-tri-O-galloyl-glucose, 1,2,3,6-tetra-O-galloyl-glucose, 1,2,3,4,6-penta-O-galloyl-glucose, tellimagrandin I, tellimagrandin II, mallotinic acid, mallotusinic acid, and geraniin. The aim of the present study was

This study was aimed at evaluating the hematinic effect of Spondias mombin and its protective role against the spleenotoxic effect of Phenylhydrazine (PHZ). Thirty Wistar rats were randomized into 6 groups. Group A (Control) animals were neither given the extract nor PHZ. Rats in groups B and C were administered 150 mg/kg body weight and 300 mg/kg body weight doses of the extract respectively. Anemia

Enantia chlorantha is a local medicinal plant commonly use in Nigeria for the treatment of diabetes but without support of scientific data. Large percentage of people suffering from diabetes who uses the plant as antidiabetic agent also combine its administration with standard antihypertensive drugs. In the present study, we have investigated the possible toxicological effects of combined administration

There is high incidence of liver and kidney diseases worldwide but medicinal plants may provide remedy. This study evaluated and compared the protective effects of Cassia spectabilis extract (CSE) and Newbouldia laevis extract (NLE) against diclofenac (DF) induced hepatorenal oxidative damage in rats. Twenty four rats were divided into 4 groups with 6 rats in each. Normal saline was given to the rats

The present study evaluated the phytochemical profiles, anti-oxidants, antimicrobial, anti-inflammatory, analgesic, anti-arthritic and wound healing effect of methanol and ethyl-acetate extracts of Azanza garckeana. Methanol extract had higher phenol, flavonoids and alkaloids concentrations, ferric reducing antioxidant power (FRAP) and hydroxyl radical scavenging activities than ethyl-acetate extract

Cuscuta reflexa (C. reflexa) Roxb. (Convolvulaceae) has medicinal properties for the effective management of several aliments including diabetes mellitus, inflammation, and gastric ulcer. The present investigation focuses on the antidiabetic potential of C. reflexa leaves methanol extract in alloxan-induced diabetic rats. The antidiabetic activity of C. reflexa leaves methanol extract (CRME) was evaluated

Insulin secretion and insulin related pathways have been the prime targets in the treatment of diabetes for a long time. However, recently a lot of attention is being directed towards addressing hyperglycaemia as the main perpetrator of the symptoms in this metabolic disorder. This new treatment approach also involves greater inclination to plant derived therapeutic agents for their safety and probable

The current study undertaken to evaluate antioxidant property of Solanum macranthum fruit methanol extract and its in-vitro cytotoxic effects on breast cancer MDA-MB-231 and mice embryo fibroblast (MEF-L929) cell line. The total alkaloids, phenols and flavonoids content in the methanol extract of S.macranthum fruit were estimated. The antioxidant activity was evaluated by FRAP assay, H2O2 scavenging

Sphaeranthus indicus is an important medicinal plant, which is used to cure various illnesses. The present study is the first investigation of the antimicrobial, antioxidant and phytochemical analysis of Sphaeranthus indicus from Chhattisgarh, India. The whole plant and plant parts were extracted with polar and non-polar solvents such as water, methanol, ethyl acetate and hexane to assess various bioactivities

Stem bark of Anogeissus latifolia Roxb (family: Combretaceae) is used traditionally and ethnomedicinally to alleviate pain, inflammation and fever conditions. The current study investigates the analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of stem bark of Anogeissus latifolia Roxb. The HPLC studies were carried out to standardize the stem bark ethanolic extract of Anogeissus

Lepidium pinnatifidum is a multipurpose, beneficial plant and known well for its indigenous therapeutic standards. Current study is aimed to investigate antioxidant and anti-inflammatory potency of Lepidium pinnatifidum. L. pinnatifidum dried powder was extracted with crude methanol (LPM) and then fractionated with various solvents to get respective fractions, termed as, n-hexane (LPH), chloroform

Diabetic is one of the fundamental persuasive of diabetic nephropathy and significantly sparks off kidney diseases and end stage renal failure globally. The current research was carried out to evaluate hypoglycemic potential and nephroprotective effect of ethanolic extract of Mikania scandens leaves by using alloxan-induced diabetic nephropathy (DN) mice. The mice were intraperitoneally treated with

Lemongrass (Cymbopogon citratus Stapf) tea is a widely consumed beverage for nourishment and the remedy of diabetes mellitus (DM) in Africa locally. The aim of the present study was to investigate the antidiabetic action of lemongrass tea (LGT) in a type 2 diabetes (T2D) model of rats. The fructose-streptozotocin (STZ) animal model for T2D was used and the LGT was prepared by boiling for 10 min in

Diabetes is a chronic metabolic disorder which affects millions of people every year. If diabetes is not controlled, it can cause serious damage and a number of health complications. The aim of this paper was to review published ethnobotanical and ethnopharmacological evidences of Moroccan plants with antidiabetic potentials. Publications describing the medicinal plants used for the treatment of diabetes

In the original publication of this article [1], an author name was misspelt. Instead of Kishore Mozumder, the author name should be Kishor Mazumder.

Consumption of plant-derived nutraceuticals and crude drugs in Arab traditional medicine is widely believed to confer beneficial effects in liver and kidney diseases. Fruits from the date palm Phoenix dactylifera L. are a rich source of nutrients and bioactive phytochemicals which possess a myriad of pharmacological effects. Herein, we examined the impact of Date Palm Pollen (DPP) aqueous suspension

Infertility is a global health burden which affect more than 15% of couples’ population. An impaired hormonal balance, oxidative stress and alteration in the physiological function of the reproductive organ are factors leading to infertility. The present study investigated the protective role of methanolic leaf extract of Vernonia amygdalina (MLVA) against Nitrobenzene-induced oxidative testicular

Avocado (Persea americana) is one of the plants widely used in ethnomedicine in Nigeria. The present study was aimed at investigating effects of aqueous Avocado (Persea americana) leaf extract on total cholesterol, triacylglycerols, protein and haematological parameters in carbon tetrachloride (CCl4)-intoxicated rats. We evaluated the possible effects of pre-treatment with aqueous extract of Persea

Jatropha tanjorensis is a commonly consumed green leafy plant that has found usage in folk medicine. Sodium benzoate (C6H5COONa) is a widely used preservative in food/drink industries with potential cytotoxicity. Protective effect of some leafy plants on xenobiotic-induced toxicity have been established. Hence, this study sought to investigate the protective effect of methanolic leaf extract of Jatropha

In the present era, the attention of nutritionist diverted towards the bioactive entities present in natural sources owing to the presence of health boosting perspectives against lifestyle related disarrays. In this context, different parts of ginger crop i.e. rhizome, leaves and flower of variety Suravi (ID no. 008) were used for the preparation of ginger extracts with 50% methanol, 50% ethanol and

This brief communication summarizes the key highlights presented at the 2019 Phytoneering Research and Experience Summit held at the Palma Convention Centre and the educational finca Sa Canova (Majorca, Spain) from the 25th to the 27th of July 2019. More than 100 professionals from academia, industry and public services took part. The scientific programme included three dedicated symposium sessions

Hydroxamic acids are currently being used in diverse biological activities. We investigated the effect of hydroxamic acid, synthesized from Cyperus esculentus seeds, on the antioxidant status of the liver, spleen, and kidney of Wistar rats. Twenty male rats were randomly divided into three treatment groups using hydroxamic acid at doses of 5, 15, and 50 mg/kg and a control group using distilled water

The Mediterranean region is characterized by a diverse vegetation cover, and the Lavandula genus is one of the most important medicinal and aromatic plants in this region. It has been used in traditional medicine as a treatment for anxiety and insomnia and to improve sleep quality for a long history. Lavender is commonly used in perfumes, soaps, bath powders, and scented sachets. It can flavor teas