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The modulation effect of green tea and pumpkin oils on hyperlipidemia, oxidative stress, and hematological abnormalities in an experimental multiple sclerosis rat model Clin. Phytosci. Pub Date : 2024-03-04 Nahed S. Lamloum, Hanan A. Soliman, Rasha Rashad Ahmed, Osama M. Ahmed, Mohamed Y. Zaky
Multiple sclerosis (MS) is a chronic inflammatory condition that can impair the body’s physiological functions. Although many diseases have been successfully treated with herbal treatments for a long time, the majority of the herbs utilized have unclear mechanisms. Therefore, this study aimed to examine the modulation effects of green tea oil (GTO) and pumpkin oil (PO) on hyperlipidemia, oxidative
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Costus speciosus leaf and seed extracts for wound healing: a comparative evaluation using mice excision wound models Clin. Phytosci. Pub Date : 2024-02-21 Shafiul Azam Zishan, Md. Maien Uddin, Mahatir Mohammad, S. M. Asadul Karim Azad, Jannatul Naima, Sadab Sipar Ibban, Md. Saiful Islam Arman
The present study investigated the potential wound healing activity comparisons between ethanol leaf & seed extracts of Costus speciosus topical formulation using mice Excision wound models, compared to Neomycin sulphate ointment as a standard drug. To assess the efficacy of Costus speciosus ointment as a potential alternative to commercially available ointments, a study was conducted using a cohort
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Effect of onions tunic extract on sodium oxalate-induced acute kidney injury Clin. Phytosci. Pub Date : 2024-02-17 Olanrewaju Sam Olayeriju, Damilola Alex Omoboyowa
Acute kidney injury (AKI) is one of the global health concerns afflicting the human population and urolithiasis (kidney stone), especially the calcium oxalate stone is the most prominent amongst the stone formers with a huge recurrence rate. This study elucidates the ameliorative potential of the tunic of onions against Wistar kidney rats toxified with sodium oxalate. Ethylacetate extract of the tunic
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Evaluation of the wound healing effect of Nishamalaki, an Ayurvedic formulation comprising Curcuma longa and Phyllanthus emblica in aging rats Clin. Phytosci. Pub Date : 2024-02-15 Vandana Panda, Lavina Vaswani, Sudhamani S, Lal Hingorani, Amol Deshmukh
There are very few drugs available for healing wounds in the aged population, which is more prone to chronic cutaneous wounds that are particularly hard to heal and require a long healing process. This study which deals with age-related wound healing, investigates the healing effect of Nishamalaki, a classic antidiabetic Ayurvedic formulation comprising turmeric (Curcuma longa) and Indian gooseberry
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Ameliorative role of diets fortified with Artocarpus altilis in a Drosophila melanogaster model of aluminum chloride-induced neurotoxicity Clin. Phytosci. Pub Date : 2024-02-04 Jamiyu Ayodeji Saliu, Ayobami Matthew Olajuyin, Samuel Faith Olowolayemo
Artocarpus altilis (breadfruit) belongs to the family Moraceae. Artocarpus altilis possesses antioxidative, anti-inflammatory, and anti-proliferative properties. Aluminum (Al) is extensively utilized for consumer products, cooking utensils, pharmaceuticals, and industries. Indication for the neurotoxicity of Al is investigated in various studies, notwithstanding the precise mechanisms of Al toxicity
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Delayed prescription of antibiotics and the capabilities of herbal medicine when used in respiratory infections Clin. Phytosci. Pub Date : 2024-01-19 V. I. Popovych, I. V. Koshel
Excessive and improper use of antibiotics in respiratory infections is still an urgent issue. In most cases of ARS and AT, antibiotics can be considered excessive treatment, since they are a completely inappropriate solution for viral infections. An important issue is negative changes to the microbiome in the patient’s body, which cause a negative impact on health, and abnormal changes can last longer
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Cardioprotective effects of Rhododendron arboreum leaf extract against Doxorubicin-induced cardiotoxicity in Wistar rats by modulating electrocardiographic and cardiac biomarkers Clin. Phytosci. Pub Date : 2023-11-22 Adersikha Pradhan, Manodeep Chakraborty, Oonglim Lepcha, Ananya Bhattacharjee, Devid Chutia, Nihar Ranjan Bhuyan
Cardiotoxicity and related complications are well-known adverse effects of anticancer drugs like doxorubicin (DOX). A medicinal plant called Rhododendron arboreum is used by traditional healers of Sikkim in the treatment of heart ailments and has also been reported for widespread therapeutic effects in many clinical studies. Thus the present study has been designed to evaluate the protective effects
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Phytochemistry, efficacy, and safety of medicinal plants used traditionally for the management of peptic ulcer diseases in Ethiopia: a systematic review Clin. Phytosci. Pub Date : 2023-11-20 Abdulkerim Mustefa, Aschalew Nardos, Dejene Hailu, Serawit Deyno
Despite significant advances in synthetic medicine, medicinal plants are still widely utilized to treat peptic ulcer disease. This study synthesized evidence on commonly used medicinal plants to manage peptic ulcer disease in Ethiopia. The evidence was synthesized using electronic databases such as PubMed/Medline, Web of Science, Science Direct, Hinari, and Google Scholar. This review considers all
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Effects of Mucuna milk (Mucuna pruriens L.) on body weight and serum biochemistry in rats fed hyperlipidaemic diet Clin. Phytosci. Pub Date : 2023-10-13 Mang Yannick Dimitry, Bidja Abena Marie Thérèse, Djiogue Manejo Josiane Edith, Abdou Bouba Armand, Njintang Yanou Nicolas
Hyperlipidemia and oxidative stress is recognized as risk factor for several diseases such as COVID-19. The aim of this study was to evaluate the effect of oral administration of Mucuna milks on body weight gain, blood lipid levels and redox status in rat model fed high fat diet. Mucuna milks were produced from two varieties of Mucuna seeds. Three controls (I, II, III) made of normal rats fed with
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Evaluating the anti-urolithiasis potential of Ficus religiosa seed GC MS evaluated phytoconstituents based on their in-vitro antioxidant properties and in-silico ADMET and molecular docking studies Clin. Phytosci. Pub Date : 2023-10-05 Felicity Pinipay, Rajesh Rokkam, Satyanarayana Botcha, Raghava Rao Tamanam
Urolithiasis, the deposit of stones in the urinary tract is a pertinent clinical issue in daily practice that imposes a burden on the human health system. Ficus religiosa plant has historically been useful in preventing urolithiasis. There is currently no information on phytochemical profiling that specifies the precise phytochemicals in the seed that are active against urolithiasis. F. religiosa seeds
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Correction to: A comparative study on the antihyperlipidemic and antibacterial potency of the shoot and flower extracts of Melastoma malabathricum Linn’s Clin. Phytosci. Pub Date : 2023-03-14 Md. Abdul Kader, Md. Masuder Rahman, Shahin Mahmud, Md. Sharif Khan, Shamsunnahar Mukta, Fatama Tous Zohora
Correction to: Clinical Phytoscience (2023) 9:5 https://doi.org/10.1186/s40816-023-00355-6 Following publication of the original article [1], the authors reported errors in the fourth and the fifth author names. The original version was: Md Sharif Khan1, Samsunnahar Mukta2 The correct version is: Md. Sharif Khan1, Shamsunnahar Mukta2 The correct author names have been provided in this Correction. The
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A comparative study on the Antihyperlipidemic and antibacterial potency of the shoot and flower extracts of Melastoma malabathricum Linn's Clin. Phytosci. Pub Date : 2023-03-01 Md. Abdul Kader, Md. Masuder Rahman, Shahin Mahmud, Md Sharif Khan, Samsunnahar Mukta, Fatama Tous Zohora
Atherosclerosis is arteries’ thickening and stiffening condition manifested due to plaque formation by oxidized-LDL of abundant and deranged lipid metabolism. Traditionally, Melastoma malabathricum Linn (MM) leaves are used for anti-diabetics, abdominal problems, and high blood pressure. The current experiment unveils the potency of ethanol, acetone, and water MM extracts as antibacterial agents and
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Analysis of anticancer potential of Kingiodendron pinnatum (DC.) Harms Clin. Phytosci. Pub Date : 2023-02-13 Chennattu M. Pareeth, Nair Meera, Prabha Silpa, Kannoor M. Thara, Achuthan C. Raghavamenon, Thekkekara D. Babu
The plant Kingiodendron pinnatum (DC.) Harms, belonging to the family Fabaceae is endemic to the Western Ghats of India and is commonly used for various ailments, especially by the tribes. K. pinnatum is occasionally used as a substitute for Saraca asoca in Asokarishta, a well-known uterine tonic in Ayurveda. Recent studies revealed a pharmacological similarity between the plants. S. asoca is reported
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In vitro evaluation of the herbal cream formulation from methanolic leaf extracts of Tephrosia vogelii Hook.f for topical application Clin. Phytosci. Pub Date : 2023-02-08 Stephano Hanolo Mlozi, Juma A. Mmongoyo, Musa N. Chacha
Topical infectious are among of global challenges which propelled up with antimicrobial resistances. This scenario compels for drug discovery and development. Herbal formulation is one of important struggle in the drug development with the purpose of overcoming various diseases distressing health care settings. Thus, this study aimed to formulate and evaluate herbal cream from leaf methanolic extracts
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Anxiolytic, analgesic and anti-inflammatory effects of Citrus maxima (Burm.) Merr. Seed extract in Swiss albino mice model Clin. Phytosci. Pub Date : 2023-02-03 Md. Tanveer Ahsan, Nazratun Noor Maria, Umme Tahmida, Ayesha Akter Jasmin, Dil Umme Salma Chowdhury
Citrus maxima (Burm.) Merr. is traditionally used for its diverse pharmacological properties. Therefore, there remains a possibility that the seed extract may contain some bioactive compounds. The present study was carried out to evaluate the anxiolytic, analgesic, and anti-inflammatory effects of methanolic seed extract of Citrus maxima (MECM). The effect of MECM on the rodent central nervous system
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Antioxidant, cytotoxic, antibacterial and thrombolytic activities of Centella asiatica L.: possible role of phenolics and flavonoids Clin. Phytosci. Pub Date : 2023-01-17 Rashid, Md. Harun-Or-, Akter, Mst. Mahmuda, Uddin, Jalal, Islam, Saziya, Rahman, Mousumy, Jahan, Khurshid, Sarker, Md. Moklesur Rahman, Sadik, Golam
Centella asiatica L. (Apiaceae), a green leafy vegetable, has been used as a popular folk medicine in Bangladesh in the treatment of various ailments. The plant is reported to contain phenolics and flavonoids, but their bioactive potentials are not yet completely known. The present study was designed to investigate the role of the phenolic and flavonoids in the antioxidant, cytotoxicity, antibacterial
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Diallyl trisulfide modulated autophagy in isoproterenol induced acute myocardial infarction Clin. Phytosci. Pub Date : 2022-12-05 El-Ashmawy, Nahla E., Khedr, Naglaa F., Shaban, Mohamed N., Al-Ashmawy, Ghada M.
Acute myocardial infarction (AMI) is the most serious manifestation of coronary artery disease. The initial ischemia in AMI causes biochemical and metabolic alterations in cardiomyocytes. The present study aimed to investigate the biomolecular mechanisms underlying cardioprotective effects of diallyl trisulfide (DATS) as well as captopril (CAP) in isoproterenol (ISO) induced AMI focusing on autophagy
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Antidiabetic properties of an Ethanolic leaf extract of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey (Asteraceae) in SD rats Clin. Phytosci. Pub Date : 2022-12-05 Adjei, De-Graft Gyamfi, Mireku-Gyimah, Nana Ama, Sarkodie, Joseph Adusei, Nguessan, Benoit Banga, Kodua, Emmanuel, Amedior, Jonathan Komla, Lartey, Irene Asare, Adi-Dako, Ofosua, Asiedu-Gyekye, Isaac Julius, Nyarko, Alexander Kwadwo
Diabetes Mellitus (DM) is a major health problem, with a global prevalence of 9.3%, 4.7% in Africa, and 2.5% in Ghana. Despite the availability of the classic anti-diabetic medications, many patients have not benefited from them due to their poor glycemic controls, high costs, inability to halt disease progression, and untoward side effects. Some patients thus resort to plant-based medicines such as
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Acrostichium aureum Linn: traditional use, phytochemistry and biological activity Clin. Phytosci. Pub Date : 2022-11-01 Akinwumi, Kazeem A., Abam, Esther O., Oloyede, Sofiat T., Adeduro, Mary N., Adeogun, Yusuf A., Uwagboe, Juanian E.
Acrostichum aureum L is an edible mangrove plant fern that grows mainly in tropical and subtropical regions of the world. This review was conducted to provide in-depth information regarding the traditional uses, phytochemistry and biological activity of A. aureum. Scientific literatures were systematically searched using databases including Google scholar, PubMed, Science Direct and ResearchGate for
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Flavonoid profile and antioxidant properties of Algerian common yew (Taxus baccata L.) Clin. Phytosci. Pub Date : 2022-09-16 Bekhouche, Mohamed, Benyammi, Roukia, Slaoui, Majda Khelifi, Krimat, Soumia, Paris, Cedric, Khelifi, Lakhdar, Morsli, Abdelkader
In humans, various diseases are associated with the accumulation of free radicals. The antioxidants can scavenge free radicals and reduce their impact; thus, the search for effective natural antioxidants of plant origin is indispensable. The present study aims to determine, for the first time, the flavonoid compounds profile and to investigate the free radical scavenging and antioxidant properties
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Pharmacoinformatic study of inhibitory potentials of selected flavonoids against papain-like protease and 3-chymotrypsin-like protease of SARS-CoV-2 Clin. Phytosci. Pub Date : 2022-09-08 Tijjani, Habibu, Adegunloye, Adegbenro P., Uba, Auwalu, Adebayo, Joseph O., Gyebi, Gideon A., Ibrahim, Ibrahim M.
Inhibition of papain-like protease (PLpro) and 3-chymotrypsin-like protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is projected to terminate its replication. Hence, these proteases represent viable therapeutic targets. Sixty-one flavonoids with reported activities against other RNA viruses were selected and docked in PLpro and 3CLpro. Flavonoids with better binding
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Irvingia gabonensis leaf extract scavenges nitric oxide and hydrogen peroxide in vitro and modulates arsenic-induced hepatic oxidative stress in wistar rats Clin. Phytosci. Pub Date : 2022-07-18 Ewere, Efosa G., Okolie, Ngozi P., Ndem, Jessie I., Eze, Gerald I., Oyebadejo, Samson A.
Arsenic is a carcinogenic heavy metal that contaminates the environment, predisposing the exposed populace to its detrimental health effects. This study investigated the liver protective effect of ethanol leaf extract of Irvingia gabonensis (ELEIG) in sodium arsenite (SA)-exposed Wistar rats and its nitric oxide (NO.) and hydrogen peroxide (H2O2)-scavenging properties in vitro. Eleven experimental
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Rice: a potential vehicle for micronutrient fortification Clin. Phytosci. Pub Date : 2022-06-02 Junaid-ur-Rahman, Syed, Chughtai, Muhammad Farhan Jahangir, Khaliq, Adnan, Liaqat, Atif, Pasha, Imran, Ahsan, Samreen, Tanweer, Saira, Saeed, Kanza, Siddiqa, Ayesha, Mehmood, Tariq, Ali, Ayesha, Aziz, Shoaib, Sameed, Nimra
The choices of consumer towards food have been changed. Consumer prefers to eat food which is not only safe but also nutritious. Now a day, they like to eat the food which promote their health and help in minimizing nutrition related health hazards. Rice is a staple food in many countries, but most emerging issue is that rice is deficit in minerals. Rice ranks second among cereals in dietary uses around
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Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months Clin. Phytosci. Pub Date : 2022-04-13 Vahlensieck, Winfried, Heim, Stefan, Patz, Brigitte, Sahin, Kurtulus
In clinical practice, plant extracts are an option to treat mild-to-moderate lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH). However, only a few herbal extracts have been investigated in long-term placebo-controlled studies. The safety and efficacy of a well-tolerated proprietary pumpkin seed soft extract (PSE) were investigated in two randomized placebo-controlled
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Phytochemical characterization and evaluation of Antiurolithiatic activity of selected source plants of Pashanabheda Clin. Phytosci. Pub Date : 2022-03-07 C. T, Sulaiman, C. K, Jyothi, G, Jinu Krishnan Unnithan, K. M, Prabhukumar, Balachandran, Indira
Pashanabheda is an important Ayurvedic drug known for diuretic and lithotriptic properties. The botanical identity of this drug is controversial as many plants like Bergenia ciliata (BC), Rotula aquatica (RA), Aerva lanata (AL) and Plectranthus amboinicus (PA) are being used as its source plants in different parts of India. This study aims at comparative phytochemical and pharmacological evaluation
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Analgesic, anti-inflammatory and NF-κB inhibitory activity of aerial parts of Cestrum diurnum Clin. Phytosci. Pub Date : 2022-03-07 Khatun, Amina, Rahman, Mahmudur, Nesa, Mst. Luthfun, Looi, Chung Yeng, Wong, Won Fen, Hazni, Hazrina, bin Mahdzir, Mohamad Azrul, Uddin, Shaikh Jamal, Awang, Khalijah, Shilpi, Jamil A.
Cestrum diurnum L. (Solanaceae), locally known as buno-Hasnahena, is widely used in different traditional medicinal practices to treat pain, burn, swelling and related disorders. Adequate evidence is not available to support its medicinal properties for further use and drug development. Present study was designed to evaluate its traditional use in pain and inflammation with further characterisation
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Acute and sub-chronic toxicity assessment and evaluation of the gastro-protective activity of polyherbal formulation “Mystomate4®” against gastric ulcer in experimental laboratory animal Clin. Phytosci. Pub Date : 2022-02-22 Awobajo, Funmileyi Olubajo, Sofidiya, Margaret Oluwatoyin, Asekun, Olayinka Taiwo, Familoni, Babafemi Oluwole
Ulcer remains a health challenge worldwide with antibiotics and proton pump inhibitors as major management therapy. The study investigated the acute, sub-chronic toxicity and gastrointestinal protective activity of a polyherbal formulation (Mystomate4®) used locally in Nigeria. Oral LD50 and the sub-chronic toxicity test were determined in mice and rats. Mice were grouped into 8 groups of 8 mice each
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A preliminary study of the efficacy of the polyherbal preparation Sao Thong Tai for erectile dysfunction among elderly men: a double-blind, randomized controlled trial Clin. Phytosci. Pub Date : 2022-02-21 Lin, Chakariya, Pattraraachachai, Junya, Pawa, Kammal K., Wongyai, Surapote
The traditional Thai polyherbal formulation “Sao Thong Tai” (STT) contains four medicinal plants, namely Boesenbergia rotunda (L.) Mansf., Sida acuta Burm.f., Dactyloctenium aegyptium (L.) Willd., and Oryza sativa L. and it is considered an aphrodisiac and remedy for the effective treatment of decreased male libido in Thai traditional medicine and it may ameliorate erectile function. This pilot study
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The role of diosgenin in crohn’s disease Clin. Phytosci. Pub Date : 2022-02-07 Ogundepo, Sunday, Chiamaka, Adinnu M., Olatinwo, Mercy, Adepoju, David, Aladesanmi, Matthias Taiwo, Celestine, Ugwu Obiora, Ali, Kingsley Chijioke, Umezinwa, Ogochukwu Jennifer, Olasore, Janet, Alausa, Abdullahi
Inflammatory bowel disease (IBD) is a chronic idiopathic inflammation that can grossly affect the entire gastrointestinal tract (GIT) from the mouth to the anus. Crohn’s disease is the most known type of IBD and has been the focus of attention due to its increase in prevalence worldwide. Although the etiology is yet to be elucidated, recent studies have pointed out Crohn’s disease to arise from a complex
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An investigationof the inhibitory effects of dichloromethane and methanol extracts of Salvia macilenta, Salvia officinalis, Salvia santolinifola and Salvia mirzayanii on diabetes marker enzymes, an approach for the treatment diabetes Clin. Phytosci. Pub Date : 2022-01-28 Javid, Hasan, Moein, Soheila, Moein, Mahmoodreza
Diabetes mellitus is a type of metabolic disease characterized by elevated blood sugar. The main strategy for its treatment is to inhibit carbohydrate-hydrolyzing enzymes, including α-amylase and α-glucosidase. The aim of the present study was to evaluate the efficacy of Salvia extracts in inhibiting diabetes marker enzymes. This experimental study was performed in vitro. The studied plants included
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Modulatory efficacy of Punica granatum L. powder ethanol extract (PLEE) on lead acetate-induced hepatic and renal toxicity Clin. Phytosci. Pub Date : 2022-01-28 Adebisi, Oluwaseun Abraham, Agbaje, Wasiu Bolade, Adewale, Omowumi Oyeronke
Pomegranate powder derived from pomegranate fruit contains phytochemicals chief of which is ellagitannins. Owing to their high antioxidative capabilities we investigated its efficacy against lead acetate induced hepatic and renal toxicity. Pomegranate powder (500 g) was procured and soaked in 1 Litre of ethanol for three days, its filtrate was concentrated and freeze dried to form Punica granatum L
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Sida acuta leaf extract attenuates oxidants-induced animal model of nephrotoxicity and hepatotoxicity Clin. Phytosci. Pub Date : 2022-01-24 Ogunmoyole, Temidayo, Falusi, Onaopemiposi Olufunke, Oderinde, Funmilayo
Curative potential of Sida acuta Burm. f. (Malvaceae) leaves on hepatotoxicity and nephrotoxicity induced by carbon tetrachloride (CCl4) and rifampicin was studied. This was aimed at providing a potent therapeutic alternative to conventional drugs in the management of liver and kidney diseases. Carbon tetrachloride (3 ml/kg bw) and rifampicn (250 mg/kg bw) were administered to induce liver and kidney
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Molecular interaction of bioactive compounds from Senecio biafrae leaf with α-amylase and α-glucosidase receptors Clin. Phytosci. Pub Date : 2022-01-24 Ajiboye, Basiru Olaitan
Diabetes mellitus is one of the silent killer diseases affecting millions of people globally and some of the key enzymes in managing this disease are α-amylase and α-glucosidase This study was designed to investigate the possible molecular interactions between various bioactive compounds of Senecio biafrae leaf on α-amylase and α-glucosidase (enzymes) receptors an important target protein in Type 2
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Current findings and future prospective of high-value trans Himalayan medicinal plant Lycium ruthenicum Murr: a systematic review Clin. Phytosci. Pub Date : 2022-01-11 Sharma, Rajni, Raghuvanshi, Rinky, Kumar, Raj, Thakur, Mohan Singh, Kumar, Santosh, Patel, Manoj K., Chaurasia, O. P., Saxena, Shweta
The genus Lycium is commercially known for its nutrient dense goji-berries, among these berries, black goji-berries obtained from Lycium ruthenicum Murr are highly valued and widely used as traditional medicine in trans-himalayan cold desert Ladakh and as functional food in several countries. The current collection of data and literature was done by exploring different scientific portals like SciFinder
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Stevia and Uncaria extract (GlucoMedix®) reduces glucose levels and the need for medications in type 2 diabetes: an open label case series of six patients Clin. Phytosci. Pub Date : 2022-01-02 Dooley, Thomas P., Pérez, Johnny Martín Paredes, Rodriquez, Carlos Rengifo
GlucoMedix® is an all-natural phytotherapy consisting of a hydro-alcoholic extract of Stevia rebaudiana (Bertoni) Bertoni and pentacyclic chemotype Uncaria tomentosa (Willd. Ex Schult.) DC. The nutraceutical product has potential for the treatment of hyperglycemia in type 2 diabetes and Metabolic Syndrome. Six adult Hispanic type 2 diabetic patients were included in an outpatient retrospective open
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Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb. Clin. Phytosci. Pub Date : 2022-01-02 Sikder, Liton, Khan, Md. Roich, Smrity, Shanita Zaman, Islam, Muhammad Torequl, Khan, Shams Ara
Traditionally, the herb Byttneria pilosa Roxb. is used for bone fractures, boils, scabies, rheumatalgia, snake bites, syphilis, elephantiasis, poisoning, and eye infection. Scientific reports suggest that it has significant anti-inflammatory, analgesic, anti-diarrheal, anxiolytic, locomotion, sedative and anti-obesity effects. This study aims at the investigation of the phytochemical and pharmacological
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Correction to: Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts Clin. Phytosci. Pub Date : 2021-12-29 Cura, Julius Kevin, Basilio, Antonio, Llagas, Ma. Cristina De Las
Correction to: Clin Phytosci 7, 94 (2021) https://doi.org/10.1186/s40816-021-00320-1 Following publication of the original article [1], the authors identified errors in Figs. 2, 4 and 5. The correct figures are given below. Fig. 2 GDRI (%) of TCE samples relative to Metformin (5%) as a function of concentrationFull size image Fig. 4 Percentage inhibition of protein denaturation of the TCE samples relative
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Anti-diabetic effect of Stachytarpheta jamaicensis on low dose streptozotocin-induced diabetic rats fed on a high-fat diet Clin. Phytosci. Pub Date : 2021-12-07 Idu, Mac Donald, Edehia, Owen – Obaseki, Gabriel, Benjamin Ogunma
This study evaluates the anti-diabetic effect of ethanol extract of Stachytarpheta jamaicensis leaf on streptozotocin (STZ) - induced diabetic rats fed on high-fat diet (HFD). Sets of male albino rats of the Wistar strain weighing between 180 and 250 g were exposed to high fat diet (margarine and oil from vegetable sources in a ratio of 2:1 w/v) for 3 weeks. Then the animals were fasted overnight;
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Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts Clin. Phytosci. Pub Date : 2021-12-02 Cura, Julius Kevin, Basilio, Antonio, Llagas, Ma. Cristina De Las
Theobroma cacao Linn. husks are considered agricultural wastes, but studies show that they exhibit natural compounds that may be used in alternative medicine. Hence, this study was conducted to determine the antidiabetic, anti-inflammatory, and cytotoxic potential of T. cacao husk aqueous extracts (TCE). A significantly higher glucose dialysis retardation index (GDRI) was shown by 10% TCE than the
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Anti-diuretic and anti-glycemic properties of Jatropha gossypiifolia L. leave extract on wistar rats Clin. Phytosci. Pub Date : 2021-12-01 Gabriel, Benjamin Ogunma, Idu, Mac Donald
Jatropha gossypiifolia L. is a widespread plant in tropical and sub-tropical countries used in traditional medicine. This study investigated the anti-diuretic and anti-hyperglycemia activities of J. gossypiifolia leave extract on streptozotocin-induced diabetic rats. The leaves was shade dried, pulverized and prepared into extract. 30, 50 and 100 mg/kg of the leaves extracts of J. gossypiifolia was
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Plantain based dough meal: nutritional property, antioxidant activity and dyslipidemia ameliorating potential in high-fat induced rats Clin. Phytosci. Pub Date : 2021-11-26 Oluwajuyitan, Timilehin David, Ijarotimi, Oluwole Steve, Fagbemi, Tayo Nathaniel
Dyslipidemia is an aberrant rise in blood lipids due to diet and lifestyle. It has implicated as the major risk factor for developing hypertension among other diseases. This study was designed to evaluate plantain based dough meal nutritional property, antioxidant activity and dyslipidemia ameliorating potential in high-fat induced rats. The flour blends, i.e., PSC (Plantain 70%, Soycake 30%), PSR
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Comparative studies on the hypoglycemic and antioxidant activities of Vernonia amygdalina delile and Baccharoides tenoreana olive in alloxan-induced hyperglycemic rats Clin. Phytosci. Pub Date : 2021-11-26 Attama, Samuel Chijioke, Aba, Patrick Emeka, Asuzu, Chinwe Uchechukwu, Asuzu, Isaac Uzoma
Vernonia amygdalina is a bitter culinary vegetable known to possess anti-diabetic principle. Baccharoides tenoreana belonging to the same species as V. amygdalina, is also used in cooking soup and it is comparatively non-bitter. However, its glycemic properties have not been studied. This study becomes imperative to find out if B. tenoreana possesses hypoglycemic and antioxidant properties and how
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Toxicological studies of aqueous and ethanol leaf extract of Spondias purpurea (red plum) in rats Clin. Phytosci. Pub Date : 2021-11-26 Gara, T. Y., Daniel, A. I., Muhammad, F. M., Ndayako, H. H.
Spondias purpurea is a flowering plant of the cashew family commonly found in South Western Nigeria. The plant is used in folk medicine for treatment of gastric disorders and diarrhoea. The purpose of the study was to investigate the haematological and histopathological effects of aqueous and ethanol leaf extract of S. purpurea (red plum) in rats. Female wistar rats weighing (121.5 ± 30.41 g) were
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Hypoglycaemic activity of Smilax canellifolia Mill. rhizomes: a bioassay-guided isolation and identification of synergistic compounds Clin. Phytosci. Pub Date : 2021-11-18 Peddie, Davia A., Bryan, Sophia J., Francis, Sheena, Alexander-Lindo, Ruby L.
Smilax canellifolia Mill. is a native shrub used in commercial root tonics as an aphrodisiac, stimulant, and pain reliever. Traditional medicine incorporates the rhizomes of S. canellifolia for the treatment of anaemia, rheumatoid arthritis, and diabetes in Jamaica and its diaspora. In particular, the use of this plant in the management of diabetes has yet to receive any scientific evaluation. In this
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Differential expression of gluconeogenic enzymes in early- and late-stage diabetes: the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model Clin. Phytosci. Pub Date : 2021-11-15 Afshari, Arezoo, Salimi, Fouzieh, Nowrouzi, Azin, Khalili, Masoumeh Babaie, Bakhtiyari, Salar, Hassanzadeh, Gholamreza, Shabani, Maryam, Ahadi, Ali, Farhadiannezhad, Masoumeh
The medicinal plant Citrullus colocynthis (L.) Schrad. (C. colocynthis) may benefit patients at different phases of diabetes by attuning to contrasting situations. Our primary objective was to find the mechanism(s) behind the antidiabetic/anti-hyperlipidemic effects of C. colocynthis seed aqueous extract (CCAE) in two different stages of type 2 diabetes (T2D) in rats. Fasting blood sugar (FBS) levels
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Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats Clin. Phytosci. Pub Date : 2021-11-15 Busari, Musa Bola, Hamzah, Rabiat Unekwu, Muhammad, Hadiza Lami, Yusuf, Ruqayyah Shehu, Madaki, Fatima Mohammad, Adeniyi, Jamiu Olabanji, Ibrahim, Yunusa Olatunji, Berinyuy, Eustace Bonghan
Liver and kidney diseases are becoming order of the day in both developed and developing countries as a result of environmental pollutants such as lead. Restorative activities of methanol and methanol/acetone phenolic-rich extracts (MPR and MAPR, respectively) of the N. latifolia fruit (NLF) on lead acetate-induced liver and kidney damaged were assessed in Wistar rats. The antioxidant activities of
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Correction to: Phytochemicals and in vitro anti-apoptotic properties of ethanol and hot water extracts of Cassava (Manihot esculenta Crantz) peel biogas slurry following anaerobic degradation Clin. Phytosci. Pub Date : 2021-11-15 Olaniyan, Oluwaseyi Paul, Ajayi, Ebenezer Idowu O.
Correction to: Clin Phytosci 7, 77 (2021) https://doi.org/10.1186/s40816-021-00311-2 Following the publication of the original article [1], the authors identified an error in the author names of Oluwaseyi Paul Olaniyan and Ebenezer Idowu O. Ajayi. The given name and family name were erroneously transposed. The incorrect author names are: Olaniyan Oluwaseyi Paul and Ajayi Ebenezer O. Idowu. The correct
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Evaluation of cerebroprotective effect of Ricinus communis leaves against ischemia reperfusion injury in rats Clin. Phytosci. Pub Date : 2021-11-12 Ahmad, Nesar, Mishra, Anuradha, Ahsan, Farogh, Khan, Zafar
Ricinus communis (RC) has been used for a long time as natural origin medicine in the treatment of central nervous system ailments. This present study was designed to identify the possible role of Ricinus communis leaves extract against ischemia-reperfusion induced-neurobehavioral changes, oxidative stress, histopathological and cellular modifications in the brain. Sprague Dawley (SD) rats (200–250 g)
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Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats Clin. Phytosci. Pub Date : 2021-11-10 Adeyi, Akindele Oluwatosin, Adams, Folasade Ajoke, Adenipekun, Clementina Oyinkansola
Pleurotus tuber-regium (P.T) is an edible mushroom with abundant polysaccharides that has been used in traditional medicine to treat diabetes mellitus. This study investigated the hypoglycaemic potential and ameliorative activity of Pleurotus tuber-regium incorporated diet on diabetes induced dyslipidaemia. Thirty five (35) adult male wistar rats were randomly assigned to seven groups; Normal control
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Efficacy and safety of Cineole (Soledum®) in the treatment of patients with acute bronchitis: results of an open-label randomized clinical phase III study Clin. Phytosci. Pub Date : 2021-11-09 Kardos, Peter, Khaletskaya, Olga, Kropova, Olga
Cineole has documented anti-inflammatory, expectorant, and mucolytic properties and has shown to be a valuable treatment option in different airway diseases. Our study examined whether a therapy with Cineole as add on to an antiviral therapy can relieve symptoms of acute bronchitis, and accelerate recovery in everyday practice. In an open-label, randomized, parallel-group phase III clinical trial,
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Baccharis trimera aqueous extract modulates inflammation and nociception in mice Clin. Phytosci. Pub Date : 2021-10-26 de Almeida, Natiely Silveira, Ferraz, Alexandre de Barros Falcão, Pedron, Claudia, Correa, Dione Silva, Vieira, Luciene Bruno, Antunes, Flavia Tasmim Techera, de Souza, Alessandra Hubner
The aerial parts of Baccharis trimera (Less.) are frequently used as a tea to treat several diseases. Therefore, the aim of this study was to identify the constituents of an aqueous extract of B. trimera, focusing on their antioxidant, anti-inflammation, and antinociception activities and properties. For that, the researchers performed in vivo assays using the formalin test and Freund’s Complete Adjuvant
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Evaluation of bioactivity and phytochemical screening of endophytic fungi isolated from Ceriops decandra (Griff.) W. Theob, a mangrove plant in Bangladesh Clin. Phytosci. Pub Date : 2021-10-18 Munshi, Mita, Sohrab, Md. Hossain, Begum, Mst. Nadira, Rony, Sattyajit Roy, Karim, Md. Adnan, Afroz, Farhana, Hasan, Md. Nazmul
Due to increasing number of individuals within the world having health issues caused by varied cancers, drug-resistant microorganism, parasitic protozoans, and fungi could be a cause for alarm. Endophyte’s are a unique source of medicinal compounds which requires an intensive seek for newer and simpler agents to handle these sickness issues is currently advancing. This study explores the description
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Antioxidant and immunomodulatory effect of AKSS16-LIV01 – a multi herbal formulation against ethanol induced liver dysfunction in mice Clin. Phytosci. Pub Date : 2021-10-12 Darbar, Soumendra, Saha, Srimoyee, Pramanik, Kausikisankar, Chattopadhyay, Atiskumar
Liver complication arises commonly due to high alcohol consumption rate. Majority of the people residing in both developed and under developed countries consuming alcohol face various liver complications such as liver fibrosis, fatty liver, liver cirrhosis and even hepatocellular carcinoma. Invention of safe and symptomatic medication to overcome this situation is a new challenge worldwide. The main
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Evaluation of clinical trials of the plants, which have ethnobotanical uses for skin disorders in Turkey: a review Clin. Phytosci. Pub Date : 2021-10-11 Alan, Zinar, Özgüldü, Halil, Erdal, Meryem Sedef, Bucak, Ayşenur Yaman, Üresin, A. Yağız, Akalın, Emine
Ethnobotanical studies investigating a large number of traditional herbs and uses have an important role in the discovery of new drugs. Nowadays, some of these traditional herbs are researched directly in the clinical trials. In this study, it is aimed to evaluate the 19 plant species that have been identified in the clinical trials among 300 plant species belonging to 79 families with traditional
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Sida acuta Burm.f. leaves ethanol extract ameliorates haematological and biochemical alterations induced by Plasmodium berghei ANKA-65 in mice Clin. Phytosci. Pub Date : 2021-10-11 Enechi, Osmond Chukwuma, Amah, Christian Chijioke, Okagu, Innocent Uzochukwu, Ononiwu, Pamela Chidinma, Nweke, Alice Chinwendu, Ugwuanyi, Theophilus Chukwudi, Ajibo, Emmanuel Arinzechukwu, Nweze, Anthonia Chiamaka, Chukwurah, Blessing Chiamaka
Malaria has continued to be a threat to man and his wellbeing, especially Africans and Asians. New antimalarial drugs are urgently needed to mitigate malaria treatment failure due to resistant Plasmodium species. Medicinal plants used by indigenous Nigerians for treating fever and malaria such as Sida acuta Burm.f. (Malvaceae) could be a promising source of lead compounds for developing new generations
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Phytochemicals and in vitro anti-apoptotic properties of ethanol and hot water extracts of Cassava peel of Cassava (Manihot Esculenta Crantz) biogas slurry following anaerobic degradation Clin. Phytosci. Pub Date : 2021-10-09 Paul, Olaniyan Oluwaseyi, Idowu, Ajayi Ebenezer O.
Wastes emanating from cassava (Manihot Esculenta Crantz) processing in African countries significantly contribute to environmental pollution, besides, such toxic wastes contribute to greenhouse gas emission. Although cassava peel has been successfully used as a raw material in mushroom cultivation, feedstock for livestock, biogas production but the bio-transformed products recovered from the anaerobic
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A formulation of Clausena anisata (Willd.) Hook. f. Ex Benth and Cassia sieberiana DC. alleviates the symptoms associated with osteoarthritis: a single-blind, randomised controlled trial of a traditional Ghanaian remedy Clin. Phytosci. Pub Date : 2021-09-30 Thomford, Kwesi Prah, Yorke, Joseph, Thomford, Ama Kyeraa, Amponsah, Isaac Kingsley
Clinical validation of herbal medicinal products is important for their widespread acceptance and application. In this single-blind, randomised controlled trial, a traditional Ghanaian herbal medicine formulation with Clausena anisata (Willd.) Hook. f. ex Benth and Cassia sieberiana DC. as ingredients was evaluated for its safety and effectiveness in the management of patients with osteoarthritis.
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Inhibition of phospholipase A2, platelet aggregation and egg albumin induced rat paw oedema as anti-inflammatory effect of Peltophorun pterocarpus stem-bark Clin. Phytosci. Pub Date : 2021-09-26 Enechi, Osmund Chukwuma, Okeke, Emmanuel Sunday, Awoh, Ogochukwu Emmanuel, Okoye, Charles Obinwanne, Odo, Chinaza Kyrian
Most medicinal plants presently employed in traditional medicine are used without scientific evidence, thereby suggesting a need to explore efficient and reliable investigations of their potential. We, therefore, conducted the present study to ascertain the efficacy of flavonoid-rich extract of Peltophorum pterocarpum sterm-bark in the treatment and management of inflammatory disorders as employed
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Safety assessment of bio-synthesized iodine-doped silver nanoparticle wound ointment in experimental rats Clin. Phytosci. Pub Date : 2021-09-23 Shittu, Oluwatosin Kudirat, Oluyomi, Olawale Issac, Gara, Theresa Yebo
In the wake of antibiotic resistance, treatment of intractable wound have been very challenging and any alternative treatment which may lead to less use of antibiotics deserves further exploitation. Nanoparticle conjugates has potentially not only reduce antibiotic use but it has been considered safe and effectively disinfect wounds already colonized with resistant bacteria as well as promoting granulation
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Impact of Althaea Officinalis extract in patients with atopic eczema: a double-blind randomized controlled trial Clin. Phytosci. Pub Date : 2021-09-01 Khalighi, Negar, Jabbari-Azad, Farahzad, Barzegar-Amini, Maral, Tavakkol-Afshari, Jalil, Layegh, Pouran, Salari, Roshanak
Althaea Officinalis introduced as an emerging anti-inflammatory agent with immunomodulatory effects that may suppress the symptoms of atopic eczema. In this study, we aimed to investigate the impact of liposomal formulation of Althaea Officinalis flower extract compared with steroids for atopic eczema treatment. In this randomized, double-blind controlled trial phase II, forty patients with moderate